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https://www.readbyqxmd.com/read/29331906/strontium-hydroxyapatite-scaffolds-engineered-with-stem-cells-aid-osteointegration-and-osteogenesis-in-osteoporotic-sheep-model
#1
Sunitha Chandran, Sachin J Shenoy, Suresh Babu S, Renjith P Nair, Varma H K, Annie John
Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing. Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs)...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29330810/correlation-of-glioma-proliferation-and-hypoxia-by-luciferase-magnetic-resonance-and-positron-emission-tomography-imaging
#2
Michael Karsy, David L Gillespie, Kevin P Horn, Lance D Burrell, Jeffery T Yap, Randy L Jensen
Gliomas are the most common type of primary, malignant brain tumor and significantly impact patients, who have a median survival of ~1 year depending on mutational background. Novel imaging modalities such as luciferase bioluminescence, micro-magnetic resonance imaging (micro-MRI), micro-computerized tomography (micro-CT), and micro-positron emission tomography (micro-PET) have expanded the portfolio of tools available to study this disease. Hypoxia, a key oncogenic driver of glioma and mechanism of resistance, can be studied in vivo by the concomitant use of noninvasive MRI and PET imaging...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29329716/gelatin-hydroxyapatite-calcium-sulphate-based-biomaterial-for-long-term-sustained-delivery-of-bone-morphogenic-protein-2-and-zoledronic-acid-for-increased-bone-formation-in-vitro-and-in-vivo-carrier-properties
#3
Deepak Bushan Raina, David Larsson, Filip Mrkonjic, Hanna Isaksson, Ashok Kumar, Lars Lidgren, Magnus Tägil
In this study, a novel macroporous composite biomaterial consisting of gelatin-hydroxyapatite-calcium sulphate for delivery of bone morphogenic protein-2 (rhBMP-2) and zoledronic acid (ZA) has been developed. The biomaterial scaffold has a porous structure and functionalization of the scaffold with rhBMP-2 induces osteogenic differentiation of MC3T3-e1 cells seen by a significant increase in biochemical and genetic markers of osteoblastic differentiation. In-vivo muscle pouch experiments showed higher mineralization using scaffold+rhBMP-2 when compared to an approved absorbable collagen sponge (ACS)+rhBMP-2 as verified by micro-CT...
January 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29328082/linear-iterative-near-field-phase-retrieval-lipr-for-dual-energy-x-ray-imaging-and-material-discrimination
#4
Heyang Thomas Li, Andrew M Kingston, Glenn R Myers, Levi Beeching, Adrian P Sheppard
Near-field x-ray refraction (phase) contrast is unavoidable in many lab-based micro-CT imaging systems. Quantitative analysis of x-ray refraction (a.k.a. phase retrieval) is in general an under-constrained problem. Regularizing assumptions may not hold true for interesting samples; popular single-material methods are inappropriate for heterogeneous samples, leading to undesired blurring and/or over-sharpening. In this paper, we constrain and solve the phase-retrieval problem for heterogeneous objects, using the Alvarez-Macovski model for x-ray attenuation...
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29327231/loading-of-the-condylar-cartilage-can-rescue-the-effects-of-botox-on-tmj
#5
Eliane H Dutra, Mara H O'Brien, Candice Logan, Aditya Tadinada, Ravindra Nanda, Sumit Yadav
The purpose of this study is to evaluate whether the effects of botulinum neurotoxin (botox) injection into the masseter in the mandibular condylar cartilage (MCC) and subchondral bone could be rescued by compressive loading of the temporomandibular joint (TMJ). Twenty-four 6-week-old female mice (C57BL/6J) were used. Mice were divided in three groups: (1) Botox (n = 8); (2) Botox plus loading (n = 8); (3) Pure control (n = 8). Bone labels (3 and 1 day before sacrifice) and the proliferation marker EdU (2 and 1 day before sacrifice) were intraperitoneally injected into all groups of mice...
January 11, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29323335/tanshinol-alleviates-impaired-bone-formation-by-inhibiting-adipogenesis-via-klf15-ppar%C3%AE-2-signaling-in-gio-rats
#6
Ya-Jun Yang, Zhu Zhu, Dong-Tao Wang, Xin-le Zhang, Yu-Yu Liu, Wen-Xiu Lai, Yu-Lin Mo, Jin Li, Yan-Long Liang, Zhuo-Qing Hu, Yong-Jie Yu, Liao Cui
Glucocorticoid (GC)-induced osteoporosis (GIO) is characterized by impaired bone formation, which can be alleviated by tanshinol, an aqueous polyphenol isolated from Salvia miltiorrhiza Bunge. In this study we investigated the molecular mechanisms underlying GC-induced modulation of osteogenesis as well as the possibility of using tanshinol to interfere with GIO. Female SD rats aged 4 months were orally administered distilled water (Con), prednisone (GC, 5 mg·kg-1·d-1), GC plus tanshinol (Tan, 16 mg·kg-1·d-1) or GC plus resveratrol (Res, 5 mg·kg-1·d-1) for 14 weeks...
January 11, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29323153/skeletal-characterization-of-the-fgfr3-mouse-model-of-achondroplasia-using-micro-ct-and-mri-volumetric-imaging
#7
Mohammed Salman Shazeeb, Megan K Cox, Anurag Gupta, Wen Tang, Kuldeep Singh, Cynthia T Pryce, Robert Fogle, Ying Mu, William D Weber, Dinesh S Bangari, Xiaoyou Ying, Yves Sabbagh
Achondroplasia, the most common form of dwarfism, affects more than a quarter million people worldwide and remains an unmet medical need. Achondroplasia is caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene which results in over-activation of the receptor, interfering with normal skeletal development leading to disproportional short stature. Multiple mouse models have been generated to study achondroplasia. The characterization of these preclinical models has been primarily done with 2D measurements...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322009/improvement-of-spatial-learning-and-memory-cortical-gyrification-patterns-and-brain-oxidative-stress-markers-in-diabetic-rats-treated-with-ficus-deltoidea-leaf-extract-and-vitexin
#8
S Nurdiana, Y M Goh, A Hafandi, S M Dom, A Nur Syimal'ain, N M Noor Syaffinaz, M Ebrahimi
Despite the fact that Ficus deltoidea and vitexin played important roles in controlling hyperglycemia, an effective mitigation strategy dealing with cognitive deficit observed in diabetes, little is known about its neuroprotective effects. The study is aimed to determine changes in behavioral, gyrification patterns and brain oxidative stress markers in streptozotocin (STZ)-induced diabetic rats following F. deltoidea and vitexin treatments. Diabetic rats were treated orally with metformin, methanolic extract of F...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29320550/longitudinal-micro-ct-as-an-outcome-measure-of-interstitial-lung-disease-in-tnf-transgenic-mice
#9
Richard D Bell, Christopher Rudmann, Ronald W Wood, Edward M Schwarz, Homaira Rahimi
INTRODUCTION: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is a debilitating condition with poor survival prognosis. High resolution computed tomography (CT) is a common clinical tool to diagnose RA-ILD, and is increasingly being adopted in pre-clinical studies. However, murine models recapitulating RA-ILD are lacking, and CT outcomes for inflammatory lung disease have yet to be formally validated. To address this, we validate μCT outcomes for ILD in the tumor necrosis factor transgenic (TNF-Tg) mouse model of RA...
2018: PloS One
https://www.readbyqxmd.com/read/29318411/cyclophilin-a-increases-cd68-cell-infiltration-in-rat-experimental-periodontitis
#10
Lande Xue, Linwang Su, Li Zhao, Jianxia Li, Yi Du, Xijiao Yu
Cyclophilin A (CyPA) is a potent chemokine, which can directly induce leukocyte chemotaxis and contribute to the pathogenesis of inflammation-mediated diseases. This study is to observe the expression and distribution of CyPA and CD68+ cells in the histopathogenesis of rat ligation-induced experimental periodontitis, and assess the role of CyPA in CD68+ cell infiltration in rat experimental periodontitis. Experimental periodontitis was induced by ligation according to our previous method. CyPA expression in gingival tissues was detected by western blotting...
January 9, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29318379/osteoinduction-and-conduction-through-absorbable-bone-substitute-materials-based-on-calcium-sulfate-in-vivo-biological-behavior-in-a-rabbit-model
#11
D Pförringer, N Harrasser, H Mühlhofer, M Kiokekli, A Stemberger, M van Griensven, M Lucke, R Burgkart, A Obermeier
Calcium sulfate (CS) can be used as an antibiotically impregnated bone substitute in a variety of clinical constellations. Antibiotically loaded bone substitutes find specific application in orthopedic and trauma surgery to prevent or treat bone infections especially in relation to open bone defects. However, its use as a structural bone graft reveals some concerns due to its fast biodegradation. The addition of calcium carbonate and tripalmitin makes CS formulations more resistant to resorption leaving bone time to form during a prolonged degradation process...
January 9, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29318031/para-aortic-lymphadenectomy-in-advanced-stage-cervical-cancer-a-protocol-for-comparing-safety-feasibility-and-diagnostic-accuracy-of-surgical-staging-versus-pet-ct-paldisc-trial
#12
Casper Tax, Karin Abbink, Maroeska M Rovers, Ruud L M Bekkers, Petra L M Zusterzeel
Background: Currently, a PET-CT is used to assess the need for extended field radiotherapy of para-aortic lymph nodes (PALN) in International Federation of Gynaecology and Obstetrics (FIGO) stage IB2, IIA2-IVA (locally advanced stage) cervical cancer. A small study established a sensitivity and specificity estimate for PALN metastases of 50% (95% CI; 7-93%) and 83% (95% CI; 52-98%), respectively. Surgical staging of PALN may lead to a higher diagnostic accuracy. However, surgical staging of para-aortic lymph nodes in locally advanced stage cervical cancer is not common practice...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29316852/a-longitudinal-study-on-timing-and-velocity-of-rat-molar-eruption-timing-of-rat-molar-eruption
#13
Balazs J Denes, Aikaterini Lagou, Domna Dorotheou, Stavros Kiliaridis
Rat molar eruption and occlusion data were compiled from several studies but several inconsistencies were found, rendering the planning of eruptional studies difficult and imprecise. Our aim was to measure eruption and occlusion days, as well as eruption velocity, in the upper and lower three molars from infancy to end of adolescence in the rat. A total of 19 male and female Wistar rats were scanned daily by micro-computed tomography (CT) from day 15 to 70. We measured the eruption of all maxillary and mandibular molars with reference points at the hard palate and mandibular canal at three stages: pre-emergent, pre-occlusal, and functional...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29315314/early-arthritis-induces-disturbances-at-bone-nanostructural-level-reflected-in-decreased-tissue-hardness-in-an-animal-model-of-arthritis
#14
Bruno Vidal, Rita Cascão, Mikko A J Finnilä, Inês P Lopes, Simo Saarakkala, Peter Zioupos, Helena Canhão, João E Fonseca
INTRODUCTION: Arthritis induces joint erosions and skeletal bone fragility. OBJECTIVES: The main goal of this work was to analyze the early arthritis induced events at bone architecture and mechanical properties at tissue level. METHODS: Eighty-eight Wistar rats were randomly housed in experimental groups, as follows: adjuvant induced arthritis (AIA) (N = 47) and a control healthy group (N = 41). Rats were monitored during 22 days for the inflammatory score, ankle perimeter and body weight and sacrificed at different time points (11 and 22 days post disease induction)...
2018: PloS One
https://www.readbyqxmd.com/read/29313816/osteopontin-regulates-dentin-and-alveolar-bone-development-and-mineralization
#15
B L Foster, M Ao, C R Salmon, M B Chavez, T N Kolli, A B Tran, E Y Chu, K R Kantovitz, M Yadav, S Narisawa, J L Millán, F H Nociti, M J Somerman
The periodontal complex is essential for tooth attachment and function and includes the mineralized tissues, cementum and alveolar bone, separated by the unmineralized periodontal ligament (PDL). To gain insights into factors regulating cementum-PDL and bone-PDL borders and protecting against ectopic calcification within the PDL, we employed a proteomic approach to analyze PDL tissue from progressive ankylosis knock-out (Ank-/-) mice, featuring reduced PPi, rapid cementogenesis, and excessive acellular cementum...
December 4, 2017: Bone
https://www.readbyqxmd.com/read/29313437/mudslide-and-or-animal-attack-are-more-plausible-causes-and-circumstances-of-death-for-al-288-lucy-a-forensic-anthropology-analysis
#16
Phillippe Charlier, Yves Coppens, Anaïs Augias, Saudamini Deo, Philippe Froesch, Isabelle Huynh-Charlier
Following a global morphological and micro-CT scan examination of the original and cast of the skeleton of Australopithecus afarensis AL 288 ('Lucy'), Kappelman et al. have recently proposed a diagnosis of a fall from a significant height (a tree) as a cause of her death. According to topographical data from the discovery site, complete re-examination of a high-quality resin cast of the whole skeleton and forensic experience, we propose that the physical process of a vertical deceleration cannot be the only cause for her observed injuries...
January 1, 2018: Medico-legal Journal
https://www.readbyqxmd.com/read/29311710/a-wnt-protein-therapeutic-improves-the-bone-forming-capacity-of-autografts-from-aged-animals
#17
Tao Chen, Jingtao Li, Luis A Córdova, Bo Liu, Sylvain Mouraret, Qiang Sun, Benjamin Salmon, Jill Helms
Autografts tend to be unreliable in older patients. Some of these age-related skeletal changes appear to be attributable to a decline in endogenous WNT signaling. We used a functional in vivo transplantation assay to demonstrate that the bone-forming capacity of an autograft can be traced back to a Wnt-responsive cell population associated with the mineralized bone matrix fraction of a bone graft. Micro-CT imaging, flow cytometry and quantitative analyses demonstrate that this mineralized fraction declines with age, along with a waning in endogenous Wnt signaling; together these factors contribute to the age-related deterioration in autograft efficacy...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311696/reliable-landmarks-for-precise-topographical-analyses-of-pathological-structural-changes-of-the-ovine-tibial-plateau-in-2-d-and-3-d-subspaces
#18
Tamás Oláh, Jan Reinhard, Liang Gao, Lars K H Goebel, Henning Madry
Selecting identical topographical locations to analyse pathological structural changes of the osteochondral unit in translational models remains difficult. The specific aim of the study was to provide objectively defined reference points on the ovine tibial plateau based on 2-D sections of micro-CT images useful for reproducible sample harvesting and as standardized landmarks for landmark-based 3-D image registration. We propose 5 reference points, 11 reference lines and 12 subregions that are detectable macroscopically and on 2-D micro-CT sections...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310434/in-vitro-and-in-vivo-studies-on-biomedical-magnesium-low-alloying-with-elements-gadolinium-and-zinc-for-orthopaedic-implant-applications
#19
Dong Bian, Jiuxu Deng, Nan Li, Xiao Chu, Yang Liu, Wenting Li, Hong Cai, Peng Xiu, Yu Zhang, Zhenpeng Guan, Yufeng Zheng, Yuhui Kou, Baoguo Jiang, Rongshi Chen
Ternary magnesium alloys with low combined-addition of elements gadolinium and zinc were developed in the present work, with their microstructures, mechanical properties, in vitro degradation behaviors and cytotoxicity being systematically studied. Furthermore, Mg-1.8Zn-0.2Gd alloy, with the best in vitro performances, was implanted into Sprague Dawley rats to examine its in vivo degradation performances up to 6 months. It was found that Mg-1.8Zn-0.2Gd, composed of single α-Mg phase, owned excellent strength and toughness that were comparable to the CE marked MAGNEZIX®, the mischmetal added Mg alloy...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29306529/comparison-of-gap-volume-after-retrofilling-using-4-different-filling-materials-evaluation-by-micro-computed-tomography
#20
Sue Youn Kim, Hyeon-Cheol Kim, Su-Jung Shin, Euiseong Kim
INTRODUCTION: The purpose of this study was to evaluate the gap volume between dentin and root-end filling materials. METHODS: Four root-end filling materials were compared in the present study: ProRoot MTA (PRM; Dentsply Tulsa Dental, Tulsa, OK), MTA Angelus (MAG; Angelus, Londrina, Brazil), EndoCem MTA (ECM; Maruchi, Wonju, Korea), and RetroMTA (RTM; BioMTA, Seoul, Korea). Forty-eight single-rooted, extracted human teeth were instrumented with nickel-titanium instruments and oburated with gutta-percha...
January 3, 2018: Journal of Endodontics
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