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Roland, john

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https://www.readbyqxmd.com/read/27904152/mitochondrial-dna-diversity-of-present-day-aboriginal-australians-and-implications-for-human-evolution-in-oceania
#1
Nano Nagle, Kaye N Ballantyne, Mannis van Oven, Chris Tyler-Smith, Yali Xue, Stephen Wilcox, Leah Wilcox, Rust Turkalov, Roland A H van Oorschot, Sheila van Holst Pellekaan, Theodore G Schurr, Peter McAllister, Lesley Williams, Manfred Kayser, R John Mitchell
Aboriginal Australians are one of the more poorly studied populations from the standpoint of human evolution and genetic diversity. Thus, to investigate their genetic diversity, the possible date of their ancestors' arrival and their relationships with neighboring populations, we analyzed mitochondrial DNA (mtDNA) diversity in a large sample of Aboriginal Australians. Selected mtDNA single-nucleotide polymorphisms and the hypervariable segment haplotypes were analyzed in 594 Aboriginal Australians drawn from locations across the continent, chiefly from regions not previously sampled...
December 1, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27870395/sex-differences-in-associations-of-arginine-vasopressin-and-oxytocin-with-resting-state-functional-brain-connectivity
#2
Leah H Rubin, Li Yao, Sarah K Keedy, James L Reilly, Jeffrey R Bishop, C Sue Carter, Hossein Pournajafi-Nazarloo, Lauren L Drogos, Carol A Tamminga, Godfrey D Pearlson, Matcheri S Keshavan, Brett A Clementz, Scot K Hill, Wei Liao, Gong-Jun Ji, Su Lui, John A Sweeney
Oxytocin (OT) and arginine vasopressin (AVP) exert robust and sexually dimorphic influences on cognition and emotion. How these hormones regulate relevant functional brain systems is not well understood. OT and AVP serum concentrations were assayed in 60 healthy individuals (36 women). Brain functional networks assessed with resting-state functional magnetic resonance imaging (rs-fMRI) were constructed with graph theory-based approaches that characterize brain networks as connected nodes. Sex differences were demonstrated in rs-fMRI...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27859519/asymmetric-inner-wedge-group-sequential-tests-with-applications-to-verifying-whether-effective-drug-concentrations-are-similar-in-adults-and-children
#3
Lisa V Hampson, Roland Fisch, Linh M Van, Thomas Jaki
Extrapolating from information available on one patient group to support conclusions about another is common in clinical research. For example, the findings of clinical trials, often conducted in highly selective patient cohorts, are routinely extrapolated to wider populations by policy makers. Meanwhile, the results of adult trials may be used to support conclusions about the effects of a medicine in children. For example, if the effective concentration of a drug can be assumed to be similar in adults and children, an appropriate paediatric dosing rule may be found by 'bridging', that is, by matching the adult effective concentration...
November 8, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27856138/predicting-three-month-functional-outcomes-after-an-ed-visit-for-acute-low-back-pain
#4
Benjamin W Friedman, Stuart Gensler, Andrew Yoon, Rebecca Nerenberg, Lynne Holden, Polly E Bijur, E John Gallagher
BACKGROUND: Nearly 30% of patients who present to an ED with acute, new onset, low back pain (LBP) report LBP-related functional impairment three months later. These patients are at risk of chronic LBP, a highly debilitating condition. It has been reported previously that functional impairment, depression, and psychosomatic symptomatology at the index visit are associated with poor LBP outcomes. We wished to replicate those findings in a cohort of ED patients, and also to determine if clinical features present at one week follow-up could predict three-month outcomes in individual patients...
November 5, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27855512/2016-white-paper-on-recent-issues-in-bioanalysis-focus-on-biomarker-assay-validation-bav-part-3-lba-biomarkers-and-immunogenicity
#5
Susan Richards, Lakshmi Amaravadi, Renuka Pillutla, Herbert Birnboeck, Albert Torri, Kyra J Cowan, Apollon Papadimitriou, Fabio Garofolo, Christina Satterwhite, Steven Piccoli, Bonnie Wu, Corinna Krinos-Fiorotti, John Allinson, Flora Berisha, Laurent Cocea, Stephanie Croft, Stephanie Fraser, Fabrizio Galliccia, Boris Gorovits, Swati Gupta, Vinita Gupta, Sam Haidar, Charles Hottenstein, Akiko Ishii-Watabe, Darshana Jani, John Kadavil, John Kamerud, Daniel Kramer, Virginia Litwin, Gustavo Mendes Lima Santos, Robert Nelson, Yan Ni, João Pedras-Vasconcelos, Yongchang Qiu, Paul Rhyne, Afshin Safavi, Yoshiro Saito, Natasha Savoie, Kara Scheibner, Eginhard Schick, Patricia Y Siguenza, John Smeraglia, Roland F Staack, Meena Subramanyam, Giane Sumner, Theingi Thway, David Uhlinger, Martin Ullmann, Alessandra Vitaliti, Jan Welink, Chan C Whiting, Li Xue, Rong Zeng
The 2016 10th Workshop on Recent Issues in Bioanalysis (10th WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations, and regulatory agencies worldwide. WRIB was once again a weeklong event - A Full Immersion Week of Bioanalysis for PK, Biomarkers and Immunogenicity. As usual, it is specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecules involving LCMS, hybrid LBA/LCMS, and LBA approaches, with the focus on PK, biomarkers and immunogenicity...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27816057/feasibility-of-alcohol-screening-among-patients-receiving-opioid-treatment-in-primary-care
#6
Anne Marie Henihan, Geoff McCombe, Jan Klimas, Davina Swan, Dorothy Leahy, Rolande Anderson, Gerard Bury, Colum P Dunne, Eamon Keenan, John S Lambert, David Meagher, Clodagh O'Gorman, Tom P O'Toole, Jean Saunders, Gillian W Shorter, Bobby P Smyth, Eileen Kaner, Walter Cullen
BACKGROUND: Identifying and treating problem alcohol use among people who also use illicit drugs is a challenge. Primary care is well placed to address this challenge but there are several barriers which may prevent this occurring. The objective of this study was to determine if a complex intervention designed to support screening and brief intervention for problem alcohol use among people receiving opioid agonist treatment is feasible and acceptable to healthcare providers and their patients in a primary care setting...
November 5, 2016: BMC Family Practice
https://www.readbyqxmd.com/read/27782537/high-speed-intermediate-resolution-large-area-laser-beam-induced-current-imaging-and-laser-scribing-system-for-photovoltaic-devices-and-modules
#7
Adam B Phillips, Zhaoning Song, Jonathan L DeWitt, Jon M Stone, Patrick W Krantz, John M Royston, Ryan M Zeller, Meghan R Mapes, Paul J Roland, Mark D Dorogi, Syed Zafar, Gary T Faykosh, Randy J Ellingson, Michael J Heben
We have developed a laser beam induced current imaging tool for photovoltaic devices and modules that utilizes diode pumped Q-switched lasers. Power densities on the order of one sun (100 mW/cm(2)) can be produced in a ∼40 μm spot size by operating the lasers at low diode current and high repetition rate. Using galvanostatically controlled mirrors in an overhead configuration and high speed data acquisition, large areas can be scanned in short times. As the beam is rastered, focus is maintained on a flat plane with an electronically controlled lens that is positioned in a coordinated fashion with the movements of the mirrors...
September 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27777231/investigating-the-relationship-between-consultation-length-and-patient-experience-a-cross-sectional-study-in-primary-care
#8
Natasha Elmore, Jenni Burt, Gary Abel, Frances A Maratos, Jane Montague, John Campbell, Martin Roland
BACKGROUND: Longer consultations in primary care have been linked with better quality of care and improved health-related outcomes. However, there is little evidence of any potential association between consultation length and patient experience. AIM: To examine the relationship between consultation length and patient-reported communication, trust and confidence in the doctor, and overall satisfaction. DESIGN AND SETTING: Analysis of 440 videorecorded consultations and associated patient experience questionnaires from 13 primary care practices in England...
October 24, 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27773786/monoclonal-antibody-therapy-for-the-treatment-of-asthma-and-chronic-obstructive-pulmonary-disease-with-eosinophilic-inflammation
#9
John Nixon, Paul Newbold, Tomas Mustelin, Gary P Anderson, Roland Kolbeck
Eosinophils have been linked with asthma for more than a century, but their role has been unclear. This review discusses the roles of eosinophils in asthma and chronic obstructive pulmonary disease (COPD) and describes therapeutic antibodies that affect eosinophilia. The aims of pharmacologic treatments for pulmonary conditions are to reduce symptoms, slow decline or improve lung function, and reduce the frequency and severity of exacerbations. Inhaled corticosteroids (ICS) are important in managing symptoms and exacerbations in asthma and COPD...
October 20, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27698072/rating-communication-in-gp-consultations-the-association-between-ratings-made-by-patients-and-trained-clinical-raters
#10
Jenni Burt, Gary Abel, Natasha Elmore, Jenny Newbould, Antoinette Davey, Nadia Llanwarne, Inocencio Maramba, Charlotte Paddison, John Benson, Jonathan Silverman, Marc N Elliott, John Campbell, Martin Roland
Patient evaluations of physician communication are widely used, but we know little about how these relate to professionally agreed norms of communication quality. We report an investigation into the association between patient assessments of communication quality and an observer-rated measure of communication competence. Consent was obtained to video record consultations with Family Practitioners in England, following which patients rated the physician's communication skills. A sample of consultation videos was subsequently evaluated by trained clinical raters using an instrument derived from the Calgary-Cambridge guide to the medical interview...
October 3, 2016: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/27679490/formation-of-nitric-oxide-by-aldehyde-dehydrogenase-2-is-necessary-and-sufficient-for-vascular-bioactivation-of-nitroglycerin
#11
Marissa Opelt, Emrah Eroglu, Markus Waldeck-Weiermair, Michael Russwurm, Doris Koesling, Roland Malli, Wolfgang F Graier, John T Fassett, Astrid Schrammel, Bernd Mayer
Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antianginal drug nitroglycerin (GTN), resulting in activation of soluble guanylate cyclase (sGC) and cGMP-mediated vasodilation. We have previously shown that a minor reaction of ALDH2-catalyzed GTN bioconversion, accounting for about 5% of the main clearance-based turnover yielding inorganic nitrite, results in direct NO formation and concluded that this minor pathway could provide the link between vascular GTN metabolism and activation of sGC...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27668515/protein-sequences-bound-to-mineral-surfaces-persist-into-deep-time
#12
Beatrice Demarchi, Shaun Hall, Teresa Roncal-Herrero, Colin L Freeman, Jos Woolley, Molly K Crisp, Julie Wilson, Anna Fotakis, Roman Fischer, Benedikt M Kessler, Rosa Rakownikow Jersie-Christensen, Jesper V Olsen, James Haile, Jessica Thomas, Curtis W Marean, John Parkington, Samantha Presslee, Julia Lee-Thorp, Peter Ditchfield, Jacqueline F Hamilton, Martyn W Ward, Chunting Michelle Wang, Marvin D Shaw, Terry Harrison, Manuel Domínguez-Rodrigo, Ross DE MacPhee, Amandus Kwekason, Michaela Ecker, Liora Kolska Horwitz, Michael Chazan, Roland Kröger, Jane Thomas-Oates, John H Harding, Enrico Cappellini, Kirsty Penkman, Matthew J Collins
Proteins persist longer in the fossil record than DNA, but the longevity, survival mechanisms and substrates remain contested. Here, we demonstrate the role of mineral binding in preserving the protein sequence in ostrich (Struthionidae) eggshell, including from the palaeontological sites of Laetoli (3.8 Ma) and Olduvai Gorge (1.3 Ma) in Tanzania. By tracking protein diagenesis back in time we find consistent patterns of preservation, demonstrating authenticity of the surviving sequences. Molecular dynamics simulations of struthiocalcin-1 and -2, the dominant proteins within the eggshell, reveal that distinct domains bind to the mineral surface...
2016: ELife
https://www.readbyqxmd.com/read/27635521/proceedings-of-the-annual-symposium-of-the-american-cochlear-implant-alliance
#13
J Thomas Roland, Craig Buchman, Laurie Eisenberg, Lillian Henderson, Shuman He, Jill Firszt, Howard Francis, Camille Dunn, Doug Sladen, Susan Arndt, Bradford May, Daniel Zeitler, John K Niparko, Susan Emmett, Debara Tucci, Joseph Chen, Amy McConkey Robbins, Ernest Schwefler, Ann Geers, Amy Lederberg, Heather Hayes, Michelle Hughes, Julie Bierer, Erin Schafer, Donna Sorkin, Linda Kozma-Spytek, Tina Childress
No abstract text is available yet for this article.
September 2016: Cochlear Implants International
https://www.readbyqxmd.com/read/27630228/magnitude-and-quality-of-cytokine-and-chemokine-storm-during-acute-infection-distinguish-nonprogressive-and-progressive-simian-immunodeficiency-virus-infections-of-nonhuman-primates
#14
Sheila M Keating, John W Heitman, Shiquan Wu, Xutao Deng, Andrea R Stacey, Roland C Zahn, Maurus de la Rosa, Samantha L Finstad, Jeffrey D Lifson, Michael Piatak, Marie-Claire Gauduin, Benedikt M Kessler, Nicola Ternette, Angela Carville, R Paul Johnson, Ronald C Desrosiers, Norman L Letvin, Persephone Borrow, Philip J Norris, Joern E Schmitz
: Acute human immunodeficiency virus (HIV) infection represents a period of intense immune perturbation and activation of the host immune system. Study of the eclipse and viral expansion phases of infection is difficult in humans, but studies in nonprogressive and progressive nonhuman primate (NHP) infection models can provide significant insight into critical events occurring during this time. Cytokines, chemokines, and other soluble immune factors were measured in longitudinal samples from rhesus macaques infected with either SIVmac251 (progressive infection) or SIVmac239Δnef (attenuated/nonprogressive infection) and from African green monkeys infected with SIVsab9315BR (nonpathogenic infection)...
November 15, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27625333/extracorporeal-membrane-oxygenation-outcomes-in-children-with-hemophagocytic-lymphohistiocytosis
#15
Katherine Cashen, Roland L Chu, Justin Klein, Peter T Rycus, John M Costello
INTRODUCTION: Pediatric patients with hemophagocytic lymphohistiocytosis (HLH) may develop refractory respiratory or cardiac failure that warrants consideration for extracorporeal membrane oxygenation (ECMO) support. The purposes of this study were to describe the use and outcomes of ECMO in pediatric HLH patients, to identify risk factors for hospital mortality and to compare their ECMO use and outcomes to the ECMO population as a whole. METHODS: Pediatric patients (⩽ 18 years) with a diagnosis of HLH in the Extracorporeal Life Support Organization (ELSO) Registry were included...
September 13, 2016: Perfusion
https://www.readbyqxmd.com/read/27621292/capturing-patient-experience-a-qualitative-study-of-implementing-real-time-feedback-in-primary-care
#16
Mary Carter, Antoinette Davey, Christine Wright, Natasha Elmore, Jenny Newbould, Martin Roland, John Campbell, Jenni Burt
BACKGROUND: In recent years, hospitals have made use of new technologies, such as real-time feedback, to collect patient experience information. This approach is currently rarely used in primary care settings, but may provide practices with a useful tool that enables them to take prompt, focused action to improve their services. AIM: To identify the factors inhibiting and enabling the implementation of real-time feedback in general practices. DESIGN AND SETTING: Qualitative study embedded within an exploratory trial (July 2014 to February 2015) of a real-time feedback intervention targeting patient experience in general practices in south-west England and Cambridgeshire...
November 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27609844/understanding-negative-feedback-from-south-asian-patients-an-experimental-vignette-study
#17
Jenni Burt, Gary Abel, Natasha Elmore, Cathy Lloyd, John Benson, Lara Sarson, Anna Carluccio, John Campbell, Marc N Elliott, Martin Roland
OBJECTIVES: In many countries, minority ethnic groups report poorer care in patient surveys. This could be because they get worse care or because they respond differently to such surveys. We conducted an experiment to determine whether South Asian people in England rate simulated GP consultations the same or differently from White British people. If these groups rate consultations similarly when viewing identical simulated consultations, it would be more likely that the lower scores reported by minority ethnic groups in real surveys reflect real differences in quality of care...
2016: BMJ Open
https://www.readbyqxmd.com/read/27564309/methylation-of-socs3-is-inversely-associated-with-metabolic-syndrome-in-an-epigenome-wide-association-study-of-obesity
#18
Omar Ali, Diana Cerjak, Jack W Kent, Roland James, John Blangero, Melanie A Carless, Yi Zhang
Epigenetic mechanisms, including DNA methylation, mediate the interaction between gene and environment and may play an important role in the obesity epidemic. We assessed the relationship between DNA methylation and obesity in peripheral blood mononuclear cells (PBMCs) at 485,000 CpG sites across the genome in family members (8-90 y of age) using a discovery cohort (192 individuals) and a validation cohort (1,052 individuals) of Northern European ancestry. After Bonferroni-correction (Pα=0.05 = 1.31 × 10(-7)) for genome-wide significance, we identified 3 loci, cg18181703 (SOCS3), cg04502490 (ZNF771), and cg02988947 (LIMD2), where methylation status was associated with body mass index percentile (BMI%), a clinical index for obesity in children, adolescents, and adults...
August 26, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27538043/in-hospital-morbidity-and-brain-metrics-of-preterm-neonates-born-1998-2009
#19
Sarah L Harris, Nicola C Austin, Malcolm Battin, Roland Broadbent, John Horwood, Ross Keenan, Scott Wells, Carole Spencer, Patricia Graham, Lianne J Woodward, Brian A Darlow
AIMS: To describe the survival, in-hospital morbidity, brain metrics and two-year neurodevelopmental outcomes of two extremely preterm cohorts and discuss the contribution of changes in clinical practice to these outcomes. METHODS: Retrospective comparative cohort study, of two cohorts of neonates born <28 weeks gestation: 47 infants born 1998-2000 and 39 infants 2006-2009. RESULTS: Comparing historical to the contemporary cohort respectively, admission temperature (35...
2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27530120/race-specific-predictors-of-mortality-in-intracerebral-hemorrhage-differential-impacts-of-intraventricular-hemorrhage-and-age-among-blacks-and-whites
#20
Roland Faigle, Elisabeth B Marsh, Rafael H Llinas, Victor C Urrutia, Rebecca F Gottesman
BACKGROUND: Intracerebral hemorrhage (ICH) carries high risk for short-term mortality. We sought to identify race-specific predictors of mortality in ICH patients. METHODS AND RESULTS: We used 2 databases, the Johns Hopkins clinical stroke database and the Nationwide Inpatient Sample (NIS). We included 226 patients with the primary diagnosis of spontaneous ICH from our stroke database between 2010 and 2013; in the NIS, 42 077 patients met inclusion criteria. Logistic regression was used to assess differences in predictors of mortality in blacks compared to whites...
August 16, 2016: Journal of the American Heart Association
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