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https://www.readbyqxmd.com/read/28056028/assessing-ultrasonography-as-a-diagnostic-tool-for-porcine-cysticercosis
#1
Robert H Flecker, Ian W Pray, Saul J Santivaňez, Viterbo Ayvar, Ricardo Gamboa, Claudio Muro, Luz Maria Moyano, Victor Benavides, Hector H Garcia, Seth E O'Neal
BACKGROUND: Taenia solium inflicts substantial neurologic disease and economic losses on rural communities in many developing nations. "Ring-strategy" is a control intervention that targets treatment of humans and pigs among clusters of households (rings) that surround pigs heavily infected with cysticerci. These pigs are typically identified by examining the animal's tongue for cysts. However, as prevalence decreases in intervened communities, more sensitive methods may be needed to identify these animals and to maintain control pressure...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28040885/gold-nanoparticle-uptake-by-human-derived-macrophages-and-primary-liver-phagocytic-cells-is-dependent-on-phenotype
#2
Sonya A MacParland, Kim M Tsoi, Ben Ouyang, Xue-Zhong Ma, Justin Manuel, Ali Fawaz, Mario A Ostrowski, Benjamin A Alman, Anton Zilman, Warren C W Chan, Ian D McGilvray
A significant challenge to delivering therapeutic doses of nanoparticles to targeted disease sites is the fact that most nanoparticles become trapped in the liver. Liver resident macrophages, or Kupffer cells, are key cells in the hepatic sequestration of nanoparticles. However, the precise role macrophage phenotype plays in nanoparticle uptake is unknown. Here, we show that human macrophage phenotype modulates hard nanoparticle uptake. Using gold nanoparticles, we examined uptake by human monocyte-derived macrophages that had been driven to a "regulatory" M2 phenotype or an "inflammatory" M1 phenotype and found that M2-type macrophages preferentially take up nanoparticles, with a clear spectrum among the subtypes (M2c>M2>M2a>M2b>M1)...
December 31, 2016: ACS Nano
https://www.readbyqxmd.com/read/28005359/cyclin-dependent-kinase-cdk-inhibitors-structure-activity-relationships-and-insights-into-the-cdk-2-selectivity-of-6-substituted-2-arylaminopurines
#3
Christopher R Coxon, Elizabeth Anscombe, Suzannah Jane Harnor, Mathew P Martin, Benoit Jean-Pierre Carbain, Bernard Thomas Golding, Ian Robert Hardcastle, Lisa K Harlow, Svitlana Korolchuk, Christopher J Matheson, David R Newell, Martin E M Noble, Mangaleswaran Sivaprakasam, Susan J Tudhope, David M Turner, Lan-Zhen Wang, Stephen R Wedge, Christopher Wong, Roger John Griffin, Jane A Endicott, Celine Cano
Purines and related heterocycles substituted at C-2 with 4'-sulfamoylanilino and at C-6 with a variety of groups have been synthesized with the aim of achieving selectivity of binding to CDK2 over CDK1. 6-Substituents that favour competitive inhibition at the ATP binding site of CDK2 were identified and typically exhibited 10-80-fold greater inhibition of CDK2 compared to CDK1. Most impressive was 4-((6-([1,1'-biphenyl]-3-yl)-9H-purin-2-yl)amino) benzenesulfonamide (73) that exhibited high potency towards CDK2 (IC50 0...
December 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27988322/a-multi-centre-evaluation-of-eleven-clinically-feasible-brain-pet-mri-attenuation-correction-techniques-using-a-large-cohort-of-patients
#4
Claes N Ladefoged, Ian Law, Udunna Anazodo, Keith St Lawrence, David Izquierdo-Garcia, Ciprian Catana, Ninon Burgos, M Jorge Cardoso, Sebastien Ourselin, Brian Hutton, Inés Mérida, Nicolas Costes, Alexander Hammers, Didier Benoit, Søren Holm, Meher Juttukonda, Hongyu An, Jorge Cabello, Mathias Lukas, Stephan Nekolla, Sibylle Ziegler, Matthias Fenchel, Bjoern Jakoby, Michael E Casey, Tammie Benzinger, Liselotte Højgaard, Adam E Hansen, Flemming L Andersen
AIM: To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal cannot easily be converted into attenuation values, making attenuation correction (AC) in PET/MRI challenging. In order to further improve the current vendor-implemented MR-AC methods for absolute quantification, a number of prototype methods have been proposed in the literature. These can be categorized into three types: template/atlas-based, segmentation-based, and reconstruction-based...
December 14, 2016: NeuroImage
https://www.readbyqxmd.com/read/27983956/increasing-the-accuracy-and-scalability-of-the-immunofluorescence-assay-for-epstein-barr-virus-by-inferring-continuous-titers-from-a-single-sample-dilution
#5
Sherry Meow Peng Goh, Muthukaruppan Swaminathan, Julian U-Ming Lai, Azlinda Anwar, Soh Ha Chan, Ian Cheong
High Epstein Barr Virus (EBV) titers detected by the indirect Immunofluorescence Assay (IFA) are a reliable predictor of Nasopharyngeal Carcinoma (NPC). Despite being the gold standard for serological detection of NPC, the IFA is limited by scaling bottlenecks. Specifically, 5 serial dilutions of each patient sample must be prepared and visually matched by an evaluator to one of 5 discrete titers. Here, we describe a simple method for inferring continuous EBV titers from IFA images acquired from NPC-positive patient sera using only a single sample dilution...
January 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27940650/autopsy-validation-of-123i-fp-cit-dopaminergic-neuroimaging-for-the-diagnosis-of-dlb
#6
Alan J Thomas, Johannes Attems, Sean J Colloby, John T O'Brien, Ian McKeith, Rodney Walker, Lean Lee, David Burn, Debra J Lett, Zuzana Walker
OBJECTIVE: To conduct a validation study of (123)I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane ((123)I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS: Patients >60 years of age with dementia who had undergone (123)I-FP-CIT imaging in research studies and who had donated their brain tissue to the Newcastle Brain Tissue Resource were included. All had structured clinical research assessments, and clinical diagnoses were applied by consensus panels using international diagnostic criteria...
December 9, 2016: Neurology
https://www.readbyqxmd.com/read/27932540/twelve-month-follow-up-on-a-randomised-controlled-trial-of-relaxation-training-for-post-stroke-anxiety
#7
Katherine Golding, Chris Fife-Schaw, Ian Kneebone
OBJECTIVE: To follow up participants in a randomised controlled trial of relaxation training for anxiety after stroke at 12 months. DESIGN: Twelve month follow-up to a randomised controlled trial, in which the control group also received treatment. SETTING: Community. PARTICIPANTS: Fifteen of twenty one original participants with post-stroke anxiety participated in a one year follow-up study. INTERVENTIONS: A self-help autogenic relaxation CD listened to five times a week for one month, immediately in the intervention group and after three months in the control group...
December 8, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27923707/three-dimensional-magnetic-resonance-imaging-quantification-of-glenoid-bone-loss-is-equivalent-to-3-dimensional-computed-tomography-quantification-cadaveric-study
#8
Adam B Yanke, Jason J Shin, Ian Pearson, Bernard R Bach, Anthony A Romeo, Brian J Cole, Nikhil N Verma
PURPOSE: To assess the ability of 3-dimensional (3D) magnetic resonance imaging (MRI, 1.5 and 3 tesla [T]) to quantify glenoid bone loss in a cadaveric model compared with the current gold standard, 3D computed tomography (CT). METHODS: Six cadaveric shoulders were used to create a bone loss model, leaving the surrounding soft tissues intact. The anteroposterior (AP) dimension of the glenoid was measured at the glenoid equator and after soft tissue layer closure the specimen underwent scanning (CT, 1...
December 3, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27905964/what-is-the-optimal-recall-period-for-verbal-autopsies-validation-study-based-on-repeat-interviews-in-three-populations
#9
Peter Serina, Ian Riley, Bernardo Hernandez, Abraham D Flaxman, Devarsetty Praveen, Veronica Tallo, Rohina Joshi, Diozele Sanvictores, Andrea Stewart, Meghan D Mooney, Christopher J L Murray, Alan D Lopez
BACKGROUND: One key contextual feature in Verbal Autopsy (VA) is the time between death and survey administration, or recall period. This study quantified the effect of recall period on VA performance by using a paired dataset in which two VAs were administered for a single decedent. METHODS: This study used information from the Population Health Metrics Research Consortium (PHMRC) Study, which collected VAs for "gold standard" cases where cause of death (COD) was supported by clinical criteria...
October 18, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27890594/an-investigation-of-trends-in-precious-metal-and-copper-content-of-ram-modules-in-weee-implications-for-long-term-recycling-potential
#10
Rhys Gareth Charles, Peter Douglas, Ingrid Liv Hallin, Ian Matthews, Gareth Liversage
Precious metal (PM) and copper content of dynamic-RAM modules placed on the market during 1991-2008 has been analysed by AAS following comminution and acid digestion. Linear regression analysis of compositional data ordered according to sample chronology was used to identify historic temporal trends in module composition resulting from changes in manufacturing practices, and to project future trends for use in more accurate assessment of future recycling potential. DRAM was found to be 'high grade' waste with: stable levels of gold and silver over time; 80% reduction in palladium content during 1991-2008; and 0...
November 24, 2016: Waste Management
https://www.readbyqxmd.com/read/27879522/a-systematic-review-of-completeness-of-reporting-in-randomized-controlled-trials-in-dermatologic-surgery-adherence-to-consort-2010-recommendations
#11
Murad Alam, Mutahir Rauf, Sana Ali, Parth Patel, Daniel I Schlessinger, Matthew R Schaeffer, Simon S Yoo, Kira Minkis, Shang I Brian Jiang, Ian A Maher, Joseph F Sobanko, Todd V Cartee, Emily Poon
BACKGROUND: Randomized controlled trials are the gold standard for comparing safety and effectiveness of surgical interventions. Reporting guidelines are available for conveying the results of such trials. OBJECTIVE: To assess adherence to standard reporting guidelines among randomized controlled trials in dermatologic surgery. MATERIALS AND METHODS: Systematic review. Data source was randomized controlled trials in the journal Dermatologic Surgery, per PubMed search, 1995 to 2014...
December 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27876146/vertical-flow-paper-sers-system-for-therapeutic-drug-monitoring-of-flucytosine-in-serum
#12
Adam G Berger, Stephen M Restaino, Ian M White
A number of life-saving drugs require therapeutic drug monitoring (TDM) for safe and effective use. Currently, however, TDM is performed using sophisticated analytical techniques relegated to central labs, increasing the cost per test and time to answer. Here, using a novel vertical flow membrane system with inkjet-printed surface enhanced Raman sensors, along with a portable spectrometer, we demonstrate a low cost and easy to use device to quantify levels of flucytosine, an antifungal that requires TDM for effective patient care, from undiluted human serum...
January 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27833459/what-is-the-optimal-recall-period-for-verbal-autopsies-validation-study-based-on-repeat-interviews-in-three-populations
#13
Peter Serina, Ian Riley, Bernardo Hernandez, Abraham D Flaxman, Devarsetty Praveen, Veronica Tallo, Rohina Joshi, Diozele Sanvictores, Andrea Stewart, Meghan D Mooney, Christopher J L Murray, Alan D Lopez
BACKGROUND: One key contextual feature in Verbal Autopsy (VA) is the time between death and survey administration, or recall period. This study quantified the effect of recall period on VA performance by using a paired dataset in which two VAs were administered for a single decedent. METHODS: This study used information from the Population Health Metrics Research Consortium (PHMRC) Study, which collected VAs for "gold standard" cases where cause of death (COD) was supported by clinical criteria...
2016: Population Health Metrics
https://www.readbyqxmd.com/read/27833088/structure-guided-design-of-purine-based-probes-for-selective-nek2-inhibition
#14
Christopher R Coxon, Christopher Wong, Richard Bayliss, Kathy Boxall, Katherine H Carr, Andrew M Fry, Ian R Hardcastle, Christopher J Matheson, David R Newell, Mangaleswaran Sivaprakasam, Huw Thomas, David Turner, Sharon Yeoh, Lan Z Wang, Roger J Griffin, Bernard T Golding, Céline Cano
Nek2 (NIMA-related kinase 2) is a cell cycle-dependent serine/threonine protein kinase that regulates centrosome separation at the onset of mitosis. Overexpression of Nek2 is common in human cancers and suppression can restrict tumor cell growth and promote apoptosis. Nek2 inhibition with small molecules, therefore, offers the prospect of a new therapy for cancer. To achieve this goal, a better understanding of the requirements for selective-inhibition of Nek2 is required. 6-Alkoxypurines were identified as ATP-competitive inhibitors of Nek2 and CDK2...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27825307/prevalence-of-latent-tuberculosis-infection-and-predictive-factors-in-an-urban-informal-settlement-in-johannesburg-south-africa-a-cross-sectional-study
#15
Jabulani R Ncayiyana, Jean Bassett, Nora West, Daniel Westreich, Eustasius Musenge, Michael Emch, Audrey Pettifor, Colleen F Hanrahan, Sheree R Schwartz, Ian Sanne, Annelies van Rie
BACKGROUND: South Africa has one of the highest burdens of latent tuberculosis infection (LTBI) in high-risk populations such as young children, adolescents, household contacts of TB cases, people living with HIV, gold miners and health care workers, but little is known about the burden of LTBI in its general population. METHODS: Using a community-based survey with random sampling, we examined the burden of LTBI in an urban township of Johannesburg and investigated factors associated with LTBI...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27808096/first-maintenance-therapy-for-copd-in-the-uk-between-2009-and-2012-a-retrospective-database-analysis
#16
David Price, Marc Miravitlles, Ian Pavord, Mike Thomas, Jadwiga Wedzicha, John Haughney, Katsiaryna Bichel, Daniel West
Clinical guidelines recommend long-acting bronchodilators as first maintenance therapy for chronic obstructive pulmonary disease (COPD), with inhaled corticosteroids (ICS) reserved for patients with more severe disease and exacerbations. The aim of this analysis was to examine real-life prescribing of first maintenance therapy for COPD in the UK. Data were extracted from the UK Optimum Patient Care Research Database for patients with a first prescription for COPD maintenance therapy between 2009 and 2012 and a diagnosis of COPD at or before the date of the first prescription for COPD maintenance therapy...
November 3, 2016: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/27803752/body-mass-index-airflow-obstruction-and-dyspnea-and-body-mass-index-airflow-obstruction-dyspnea-scores-age-and-pack-years-predictive-properties-of-new-multidimensional-prognostic-indices-of-chronic-obstructive-pulmonary-disease-in-primary-care
#17
Khalid Ansari, Niall Keaney, Andrea Kay, Monica Price, Joan Munby, Andrew Billett, Sharon Haggerty, Ian K Taylor, Hajed Al Otaibi
BACKGROUND: The assessment of the severity of chronic obstructive pulmonary disease (COPD) should involve a multidimensional approach that is now clearly shown to be better than using spirometric impairment alone. The aim of this study is to validate and compare novel tools without an exercise test and to extend prognostic value to patients with less severe impairment of Forced expiratory volume 1 s. METHODS: A prospective, observational, primary care cohort study identified 458 eligible patients recruited from the primary care clinics in the northeast of England in 1999-2002...
October 2016: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/27771614/same-map-different-direction-exploring-new-opportunities-that-dementia-care-mapping%C3%A2-can-offer-to-acute-mental-health-admission-wards-for-older-people-innovative-practice
#18
Sean Page, Ian Davies-Abbott, Mat Phillips
Dementia Care Mapping™ is widely acknowledged as the gold standard observational method that can support the introduction of person centred care into a variety of settings (http://www.bradford.ac.uk/health/dementia/dementia-care-mapping/). It encourages care staff to think about how the person with dementia is experiencing the care provided and the care setting. It has been shown to raise care staff awareness sufficiently to bring about improvements in care. In this paper, we describe a programme of work in North Wales that seeks to find innovative ways to use Dementia Care Mapping™, in acute mental health admission wards for people affected by dementia, and we set out some of those innovations...
October 21, 2016: Dementia
https://www.readbyqxmd.com/read/27759783/estimating-basal-energy-expenditure-in-liver-transplant-recipients-the-value-of-the-harris-benedict-equation
#19
Andressa S Pinto, Marcio F Chedid, Léa T Guerra, Mario R Álvares-DA-Silva, Alexandre de Araújo, Luciano S Guimarães, Ian Leipnitz, Aljamir D Chedid, Cleber R P Kruel, Tomaz J M Grezzana-Filho, Cleber D P Kruel
Background: Reliable measurement of basal energy expenditure (BEE) in liver transplant (LT) recipients is necessary for adapting energy requirements, improving nutritional status and preventing weight gain. Indirect calorimetry (IC) is the gold standard for measuring BEE. However, BEE may be estimated through alternative methods, including electrical bioimpedance (BI), Harris-Benedict Equation (HBE), and Mifflin-St. Jeor Equation (MSJ) that carry easier applicability and lower cost. Aim: To determine which of the three alternative methods for BEE estimation (HBE, BI and MSJ) would provide most reliable BEE estimation in LT recipients...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27726797/mouse-and-guinea-pig-models-of-tuberculosis
#20
Ian M Orme, Diane J Ordway
This article describes the nature of the host response to Mycobacterium tuberculosis in the mouse and guinea pig models of infection. It describes the great wealth of information obtained from the mouse model, reflecting the general availability of immunological reagents, as well as genetic manipulations of the mouse strains themselves. This has led to a good understanding of the nature of the T-cell response to the infection, as well as an appreciation of the complexity of the response involving multiple cytokine- and chemokine-mediated systems...
August 2016: Microbiology Spectrum
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