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https://www.readbyqxmd.com/read/29455722/computer-assisted-motivational-interviewing-intervention-to-facilitate-teen-pregnancy-prevention-and-fitness-behavior-changes-a-randomized-trial-for-young-men
#1
David L Bell, Samantha Garbers, Marina Catallozzi, R Stanley Hum, Meredith Nechitilo, Ian W McKeague, Emilia H Koumans, L Duane House, Susan L Rosenthal, Melanie A Gold
PURPOSE: Despite recent declines, teen unintended pregnancy and sexually transmitted infections in the United States remain at levels higher than comparable nations. Initiatives to prevent teen pregnancy have focused primarily on female adolescents; how to effectively engage young men to reduce their risk of fathering a teen pregnancy has not been well studied. We proposed to adapt an innovative computer-assisted motivational interviewing (CAMI) intervention, originally designed and tested with young women, for use with young men, aged 15-24 years, to reduce their risk of fathering a teen pregnancy...
March 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29417116/new-reactivity-at-the-silicon-bridge-in-sila-1-ferrocenophanes
#2
Rebecca A Musgrave, Rebekah L N Hailes, André Schäfer, Andrew D Russell, Paul J Gates, Ian Manners
We describe two new types of reactivity involving silicon-bridged [1]ferrocenophanes. In an attempt to form a [1]ferrocenophane with a bridging silyl cation, the reaction of sila[1]ferrocenophane [Fe(η-C5H4)2Si(H)TMP] (12) (TMP = 2,2,6,6-tetramethylpiperidyl) towards the hydride-abstraction reagent trityl tetrakis(pentafluorophenyl)borate ([CPh3][B(C6F5)4]) was explored. This yielded the unusual dinuclear species [Fe(η-C5H4)2Si(TMP·H)(η-C5H3)Fe(η-C5H4)Si(H)TMP][B(C6F5)4] [13][B(C6F5)4] in low yield. The formation of [13]+ is proposed to involve abstraction of hydride from the silicon bridge in 12 with subsequent C-H bond cleavage of a cyclopentadienyl group by the resulting electrophilic transient silyl cation intermediate...
February 8, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29410364/counterpoint-should-an-attempt-be-made-to-withdraw-inhaled-corticosteroids-in-all-patients-with-stable-gold-3-30-%C3%A2-fev1-50-predicted-copd-no
#3
EDITORIAL
https://www.readbyqxmd.com/read/29400453/competitive-self-assembly-kinetics-as-a-route-to-control-the-morphology-of-core-crystalline-cylindrical-micelles
#4
Jiangping Xu, Hang Zhou, Qing Yu, Ian Manners, Mitchell A Winnik
Nucleated self-assembly in selective solvents of core-crystalline block copolymers (BCPs) is a special case of living supramolecular polymerization, leading to rodlike micelles of controlled and uniform length. For the crystallization-driven self-assembly of PFS-containing BCPs (PFS = polyferrocenyldimethylsilane), the formation of block comicelles by sequential addition of different BCPs is well-established. But there are only a few examples of living copolymerization, the simultaneous addition of pairs of BCPs with different corona-forming chains...
February 5, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29384434/the-psychomotor-vigilance-test-a-comparison-of-different-test-durations-in-elite-athletes
#5
Maddison J Jones, Ian C Dunican, Kevin Murray, Peter Peeling, Brian Dawson, Shona Halson, Joanna Miller, Peter R Eastwood
The 10-min Psychomotor Vigilance Test (PVT-10) is regarded as the gold-standard for assessing vigilant attention following sleep loss; however, other studies have investigated whether shorter versions of the test elicit similar results to the PVT-10. The present study compared the PVT-10 with 3-min (PVT-3) and 5-min (PVT-5) versions of the test in elite female basketball players. Athletes performed all three tests in the morning and evening for seven consecutive days. Response speed (mean reciprocal reaction time; mean 1/RT), number of errors and number of lapses were determined for each test and time point...
January 31, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29324648/lspr-and-interferometric-sensor-modalities-combined-using-a-double-clad-optical-fiber
#6
Harald Ian Muri, Andon Bano, Dag Roar Hjelme
We report on characterization of an optical fiber-based multi-parameter sensor concept combining localized surface plasmon resonance (LSPR) signal and interferometric sensing using a double-clad optical fiber. The sensor consists of a micro-Fabry-Perot in the form of a hemispherical stimuli-responsive hydrogel with immobilized gold nanorods on the facet of a cleaved double-clad optical fiber. The swelling degree of the hydrogel is measured interferometrically using the single-mode inner core, while the LSPR signal is measured using the multi-mode inner cladding...
January 11, 2018: Sensors
https://www.readbyqxmd.com/read/29322773/sers-based-label-free-insulin-detection-at-physiological-concentrations-for-analysis-of-islet-performance
#7
Hyunjun Cho, Shailabh Kumar, Daejong Yang, Sagar R Vaidyanathan, Kelly Woo, Ian Garcia, Hao Jan Shue, Youngzoon Yoon, Kevin Ferreri, Hyuck Choo
Label-free optical detection of insulin would allow in vitro assessment of pancreatic cell functions in their natural state and expedite diabetes-related clinical research and treatment, however no existing method has met these criteria at physiological concentrations. Using spatially-uniform 3D gold-nanoparticle sensors, we have demonstrated surface-enhanced Raman sensing of insulin in the secretions from human pancreatic islets under low and high glucose environments without the use of labels such as antibodies or aptamers...
January 11, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29312616/detection-of-hpv-related-oropharyngeal-cancer-in-oral-rinse-specimens
#8
Matthew Rosenthal, Bin Huang, Nora Katabi, Jocelyn Migliacci, Robert Bryant, Samuel Kaplan, Timothy Blackwell, Snehal Patel, Liying Yang, Zhiheng Pei, Yi-Wei Tang, Ian Ganly
Background: The majority of patients diagnosed with oropharyngeal squamous cell cancer (OPSCC) are due to HPV infection. At present, there are no reliable tests for screening HPV in patients with OPSCC. The objective of this study was to assess the Cobas® HPV Test on oral rinse specimens as an early, non-invasive tool for HPV-related OPSCC. Methods: Oral rinse specimens were collected from 187 patients (45 with OPSCC, 61 with oral cavity SCC (OCSCC) and 81 control patients who had benign or malignant thyroid nodules) treated at MSKCC...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29291499/the-facile-removal-of-ctab-from-the-surface-of-gold-nanorods
#9
Jie He, Sarah Unser, Ian Bruzas, ReJeana Cary, Zhiwei Shi, Rajesh Mehra, Kenneth Aron, Laura Sagle
A common capping agent for gold nanorods, Cetyl trimethylammonium bromide (CTAB), is particularly problematic for biological studies because of its cytotoxicity. Several procedures have been developed to remove the CTAB from the surface of the gold nanorods, but most are lengthy, involving many steps, and use expensive reagents. Here, we present a simple, one-pot method for the complete removal of CTAB from the surface of gold nanorods, so that particles can be more effectively utilized in biological in vivo studies...
December 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29261297/synthesis-and-evaluation-of-doxorubicin-loaded-gold-nanoparticles-for-tumor-targeted-drug-delivery
#10
Yongle Du, Long Xia, Ami Jo, Richey M Davis, Philippe Bissel, Marion Ehrich, David George Ian Kingston
Doxorubicin is an effective and widely used cancer chemotherapeutic agent, but its application is greatly compromised by its cumulative dose-dependent side effect of cardiotoxicity. A gold nanoparticle-based drug delivery system has been designed to overcome this limitation. Five novel thiolated doxorubicin analogs were synthesized and their biological activities evaluated. Two of these analogs and PEG stabilizing ligands were then conjugated to gold nanoparticles, and the resulting Au-Dox constructs were evaluated...
December 20, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29235907/a-validation-study-of-fitbit-charge-2%C3%A2-compared-with-polysomnography-in-adults
#11
Massimiliano de Zambotti, Aimee Goldstone, Stephanie Claudatos, Ian M Colrain, Fiona C Baker
We evaluated the performance of a consumer multi-sensory wristband (Fitbit Charge 2™), against polysomnography (PSG) in measuring sleep/wake state and sleep stage composition in healthy adults. In-lab PSG and Fitbit Charge 2™ data were obtained from a single overnight recording at the SRI Human Sleep Research Laboratory in 44 adults (19-61 years; 26 women; 25 Caucasian). Participants were screened to be free from mental and medical conditions. Presence of sleep disorders was evaluated with clinical PSG...
December 13, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29186839/lspr-coupling-and-distribution-of-interparticle-distances-between-nanoparticles-in-hydrogel-on-optical-fiber-end-face
#12
Harald Ian Muri, Dag Roar Hjelme
We report on a new localized surface plasmon resonance (LSPR)-based optical fiber (OF) architecture with a potential in sensor applications. The LSPR-OF system is fabricated by immobilizing gold nanoparticles (GNPs) in a hydrogel droplet polymerized on the fiber end face. This design has several advantages over earlier designs. It dramatically increase the number nanoparticles (NP) available for sensing, it offers precise control over the NP density, and the NPs are positioned in a true 3D aqueous environment...
November 25, 2017: Sensors
https://www.readbyqxmd.com/read/29169740/redefining-cut-points-for-high-symptom-burden-of-the-global-initiative-for-chronic-obstructive-lung-disease-classification-in-18-577-patients-with-chronic-obstructive-pulmonary-disease
#13
Dionne E Smid, Frits M E Franssen, Maria Gonik, Marc Miravitlles, Ciro Casanova, Borja G Cosio, Pilar de Lucas-Ramos, Jose M Marin, Cristina Martinez, Isabel Mir, Joan B Soriano, Juan P de Torres, Alvar Agusti, Nart B Atalay, Julia Billington, Afroditi K Boutou, Stefanie Brighenti-Zogg, Emma Chaplin, Samantha Coster, James W Dodd, Selina Dürr, Alberto Fernandez-Villar, Miriam T J Groenen, Miguel Guimarães, Karel Hejduk, Victoria Higgins, Nicholas S Hopkinson, Nobuyuki Horita, Sarah Houben-Wilke, Daisy J A Janssen, Melissa Jehn, Rudolf Joerres, Annika Karch, Julia L Kelly, Yu-Il Kim, Hiroshi Kimura, Vladimir Koblizek, Janwillem H Kocks, Samantha S C Kon, Namhee Kwon, Inês Ladeira, Sang-Do Lee, Joerg D Leuppi, Nicholas Locantore, José L Lopez-Campos, William D-C Man, Lana Maricic, Laura Mendoza, David Miedinger, Florin Mihaltan, Seigo Minami, Thys van der Molen, Trevor J Murrells, Nienke Nakken, Yu Nishijima, Ian J Norman, Barbora Novotna, Denis E O'Donnell, Yoshitaka Ogata, Eanes D Pereira, James Piercy, David Price, Chaicharn Pothirat, Natya Raghavan, Thomas Ringbaek, Dimitar Sajkov, Naseh Sigari, Sally Singh, Mark Small, Guilherme F da Silva, Rebecca J Tanner, Ioanna G Tsiligianni, Baykal Tulek, Nikolaos Tzanakis, Lowie E G W Vanfleteren, Henrik Watz, Katherine A Webb, Emiel F M Wouters, Guogang G Xie, Masanori Yoshikawa, Martijn A Spruit
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) can be classified into groups A/C or B/D based on symptom intensity. Different threshold values for symptom questionnaires can result in misclassification and, in turn, different treatment recommendations. The primary aim was to find the best fitting cut-points for Global initiative for chronic Obstructive Lung Disease (GOLD) symptom measures, with an modified Medical Research Council dyspnea grade of 2 or higher as point of reference...
December 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29166778/a-pilot-randomized-controlled-trial-of-self-help-relaxation-to-reduce-post-stroke-depression
#14
Katherine Golding, Chris Fife-Schaw, Ian Kneebone
OBJECTIVE: To consider the potential of self-help relaxation training to treat depression after stroke. DESIGN: Randomized controlled trial with cross-over at three months. SETTING: Community. PARTICIPANTS: In total, 21 people with stroke, aged 49-82 years. INTERVENTION: Autogenic relaxation CD. MAIN MEASURE: Hospital Anxiety and Depression Scale-Depression (HADS-D) subscale...
November 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29144010/self-assembly-and-surface-patterning-of-polyferrocenylsilane-functionalized-gold-nanoparticles
#15
Rachelle M Choueiri, Anna Klinkova, Samuel Pearce, Ian Manners, Eugenia Kumacheva
Chemical and topographic surface patterning of inorganic polymer-functionalized nanoparticles (NPs) and their self-assembly in nanostructures with controllable architectures enable the design of new NP-based materials. Capping of NPs with inorganic polymer ligands, such as metallopolymers, can lead to new synergetic properties of individual NPs or their assemblies, and enhance NP processing in functional materials. Here, for gold NPs functionalized with polyferrocenylsilane, two distinct triggers are used to induce attraction between the polymer ligands and achieve NP self-assembly or topographic surface patterning of individual polymer-capped NPs...
November 16, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29131859/development-and-validation-of-an-immunoperoxidase-antigen-detection-test-for-improved-diagnosis-of-rabies-in-indonesia
#16
Ibnu Rahmadane, Andrea F Certoma, Grantley R Peck, Yul Fitria, Jean Payne, Axel Colling, Brian J Shiell, Gary Beddome, Susanne Wilson, Meng Yu, Chris Morrissy, Wojtek P Michalski, John Bingham, Ian A Gardner, John D Allen
Rabies continues to pose a significant threat to human and animal health in regions of Indonesia. Indonesia has an extensive network of veterinary diagnostic laboratories and the 8 National laboratories are equipped to undertake diagnostic testing for rabies using the commercially-procured direct fluorescent antibody test (FAT), which is considered the reference (gold standard) test. However, many of the Indonesian Provincial diagnostic laboratories do not have a fluorescence microscope required to undertake the FAT...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29129177/copd-x-australian-and-new-zealand-guidelines-for-the-diagnosis-and-management-of-chronic-obstructive-pulmonary-disease-2017-update
#17
Ian A Yang, Juliet L Brown, Johnson George, Sue Jenkins, Christine F McDonald, Vanessa M McDonald, Kirsten Phillips, Brian J Smith, Nicholas A Zwar, Eli Dabscheck
Chronic obstructive pulmonary disease (COPD) is characterised by persistent respiratory symptoms and chronic airflow limitation, and is associated with exacerbations and comorbidities. Advances in the management of COPD are updated quarterly in the national COPD guidelines, the COPD-X plan, published by Lung Foundation Australia in conjunction with the Thoracic Society of Australia and New Zealand and available at http://copdx.org.au. Main recommendations: Spirometry detects persistent airflow limitation (post-bronchodilator FEV1/FVC < 0...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29125298/surface-initiated-ring-opening-metathesis-polymerization-of-dicyclopentadiene-from-the-vapor-phase
#18
Ian Njoroge, Paul A Kempler, Xuanli Deng, Steven T Arnold, G Kane Jennings
Surface-tethered polydicyclopentadiene (pDCPD) films were prepared on gold and silicon substrates via surface-initiated ring-opening polymerization (SI-ROMP) of dicyclopentadiene (DCPD). The films were grown utilizing monomer in both the vapor phase and the solution phase with the former process exhibiting rapid kinetics producing ∽ 400 nm thick pDCPD films in less than 1 min of polymerization. No significant differences in thickness were observed for films grown from monomer in the vapor phase with the different isomers (exo and endo) of DCPD...
November 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29083408/exome-wide-association-study-of-plasma-lipids-in-300-000-individuals
#19
Dajiang J Liu, Gina M Peloso, Haojie Yu, Adam S Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves, Philippe Amouyel, Emanuele Di Angelantonio, Dominique Arveiler, Themistocles L Assimes, Paul L Auer, Usman Baber, Christie M Ballantyne, Lia E Bang, Marianne Benn, Joshua C Bis, Michael Boehnke, Eric Boerwinkle, Jette Bork-Jensen, Erwin P Bottinger, Ivan Brandslund, Morris Brown, Fabio Busonero, Mark J Caulfield, John C Chambers, Daniel I Chasman, Y Eugene Chen, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, John M Connell, Francesco Cucca, L Adrienne Cupples, Scott M Damrauer, Gail Davies, Ian J Deary, George Dedoussis, Joshua C Denny, Anna Dominiczak, Marie-Pierre Dubé, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Aliki-Eleni Farmaki, Mary F Feitosa, Marco Ferrario, Jean Ferrieres, Ian Ford, Myriam Fornage, Paul W Franks, Timothy M Frayling, Ruth Frikke-Schmidt, Lars G Fritsche, Philippe Frossard, Valentin Fuster, Santhi K Ganesh, Wei Gao, Melissa E Garcia, Christian Gieger, Franco Giulianini, Mark O Goodarzi, Harald Grallert, Niels Grarup, Leif Groop, Megan L Grove, Vilmundur Gudnason, Torben Hansen, Tamara B Harris, Caroline Hayward, Joel N Hirschhorn, Oddgeir L Holmen, Jennifer Huffman, Yong Huo, Kristian Hveem, Sehrish Jabeen, Anne U Jackson, Johanna Jakobsdottir, Marjo-Riitta Jarvelin, Gorm B Jensen, Marit E Jørgensen, J Wouter Jukema, Johanne M Justesen, Pia R Kamstrup, Stavroula Kanoni, Fredrik Karpe, Frank Kee, Amit V Khera, Derek Klarin, Heikki A Koistinen, Jaspal S Kooner, Charles Kooperberg, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo Lakka, Claudia Langenberg, Anne Langsted, Lenore J Launer, Torsten Lauritzen, David C M Liewald, Li An Lin, Allan Linneberg, Ruth J F Loos, Yingchang Lu, Xiangfeng Lu, Reedik Mägi, Anders Malarstig, Ani Manichaikul, Alisa K Manning, Pekka Mäntyselkä, Eirini Marouli, Nicholas G D Masca, Andrea Maschio, James B Meigs, Olle Melander, Andres Metspalu, Andrew P Morris, Alanna C Morrison, Antonella Mulas, Martina Müller-Nurasyid, Patricia B Munroe, Matt J Neville, Jonas B Nielsen, Sune F Nielsen, Børge G Nordestgaard, Jose M Ordovas, Roxana Mehran, Christoper J O'Donnell, Marju Orho-Melander, Cliona M Molony, Pieter Muntendam, Sandosh Padmanabhan, Colin N A Palmer, Dorota Pasko, Aniruddh P Patel, Oluf Pedersen, Markus Perola, Annette Peters, Charlotta Pisinger, Giorgio Pistis, Ozren Polasek, Neil Poulter, Bruce M Psaty, Daniel J Rader, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Frida Renström, Stephen S Rich, Paul M Ridker, John D Rioux, Neil R Robertson, Dan M Roden, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Serena Sanna, Naveed Sattar, Ellen M Schmidt, Robert A Scott, Peter Sever, Raquel S Sevilla, Christian M Shaffer, Xueling Sim, Suthesh Sivapalaratnam, Kerrin S Small, Albert V Smith, Blair H Smith, Sangeetha Somayajula, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Kathleen E Stirrups, Nathan Stitziel, Konstantin Strauch, Heather M Stringham, Praveen Surendran, Hayato Tada, Alan R Tall, Hua Tang, Jean-Claude Tardif, Kent D Taylor, Stella Trompet, Philip S Tsao, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Natalie R van Zuydam, Anette Varbo, Tibor V Varga, Jarmo Virtamo, Melanie Waldenberger, Nan Wang, Nick J Wareham, Helen R Warren, Peter E Weeke, Joshua Weinstock, Jennifer Wessel, James G Wilson, Peter W F Wilson, Ming Xu, Hanieh Yaghootkar, Robin Young, Eleftheria Zeggini, He Zhang, Neil S Zheng, Weihua Zhang, Yan Zhang, Wei Zhou, Yanhua Zhou, Magdalena Zoledziewska, Joanna M M Howson, John Danesh, Mark I McCarthy, Chad A Cowan, Goncalo Abecasis, Panos Deloukas, Kiran Musunuru, Cristen J Willer, Sekar Kathiresan
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD...
October 30, 2017: Nature Genetics
https://www.readbyqxmd.com/read/29031848/local-national-and-regional-viral-haemorrhagic-fever-pandemic-potential-in-africa-a-multistage-analysis
#20
David M Pigott, Aniruddha Deshpande, Ian Letourneau, Chloe Morozoff, Robert C Reiner, Moritz U G Kraemer, Shannon E Brent, Isaac I Bogoch, Kamran Khan, Molly H Biehl, Roy Burstein, Lucas Earl, Nancy Fullman, Jane P Messina, Adrian Q N Mylne, Catherine L Moyes, Freya M Shearer, Samir Bhatt, Oliver J Brady, Peter W Gething, Daniel J Weiss, Andrew J Tatem, Luke Caley, Tom De Groeve, Luca Vernaccini, Nick Golding, Peter Horby, Jens H Kuhn, Sandra J Laney, Edmond Ng, Peter Piot, Osman Sankoh, Christopher J L Murray, Simon I Hay
BACKGROUND: Predicting when and where pathogens will emerge is difficult, yet, as shown by the recent Ebola and Zika epidemics, effective and timely responses are key. It is therefore crucial to transition from reactive to proactive responses for these pathogens. To better identify priorities for outbreak mitigation and prevention, we developed a cohesive framework combining disparate methods and data sources, and assessed subnational pandemic potential for four viral haemorrhagic fevers in Africa, Crimean-Congo haemorrhagic fever, Ebola virus disease, Lassa fever, and Marburg virus disease...
December 16, 2017: Lancet
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