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ian gold

Martha G Pamato, Ian G Wood, David P Dobson, Simon A Hunt, Lidunka Vočadlo
On the basis of ab initio computer simulations, pre-melting phenomena have been suggested to occur in the elastic properties of hexagonal close-packed iron under the conditions of the Earth's inner core just before melting. The extent to which these pre-melting effects might also occur in the physical properties of face-centred cubic metals has been investigated here under more experimentally accessible conditions for gold, allowing for comparison with future computer simulations of this material. The thermal expansion of gold has been determined by X-ray powder diffraction from 40 K up to the melting point (1337 K)...
April 1, 2018: Journal of Applied Crystallography
Divya Mohan, Julia R Forman, Matthew Allinder, Carmel M McEniery, Charlotte Emma Bolton, John R Cockcroft, William MacNee, Jonathan Fuld, Mellone Marchong, Nichola Sian Gale, Marie Fisk, Sridevi Nagarajan, Joseph Cheriyan, David A Lomas, Peter M A Calverley, Bruce E Miller, Ruth Tal-Singer, Ian B Wilkinson, Michael I Polkey
Cardiovascular and skeletal muscle manifestations constitute important comorbidities in COPD, with systemic inflammation proposed as a common mechanistic link. Fibrinogen has prognostic role in COPD. We aimed to determine whether aortic stiffness and quadriceps weakness are linked in COPD, and whether they are associated with the systemic inflammatory mediator-fibrinogen. Aortic pulse wave velocity (aPWV), quadriceps maximal volitional contraction (QMVC) force and fibrinogen were measured in 729 patients with stable, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages II-IV COPD...
April 4, 2018: Thorax
Sarah N Innes-Gold, Ian L Morgan, Omar A Saleh
Single-molecule measurements of polymer elasticity are powerful, direct probes of both biomolecular structure and principles of polymer physics. Recent work has revealed low-force regimes in which biopolymer elasticity is understood through blob-based scaling models. However, the small tensions required to observe these regimes have the potential to create measurement biases, particularly due to the increased interactions of the polymer chain with tethering surfaces. Here, we examine one experimentally observed bias, in which fluctuation-based estimates of elasticity report an unexpectedly low chain compliance...
March 28, 2018: Journal of Chemical Physics
Ralph N Martins, Victor Villemagne, Hamid R Sohrabi, Pratishtha Chatterjee, Tejal M Shah, Giuseppe Verdile, Paul Fraser, Kevin Taddei, Veer B Gupta, Stephanie R Rainey-Smith, Eugene Hone, Steve Pedrini, Wei Ling Lim, Ian Martins, Shaun Frost, Sunil Gupta, Sid O'Bryant, Alan Rembach, David Ames, Kathryn Ellis, Stephanie J Fuller, Belinda Brown, Samantha L Gardener, Binosha Fernando, Prashant Bharadwaj, Samantha Burnham, Simon M Laws, Anna M Barron, Kathryn Goozee, Eka J Wahjoepramono, Prita R Asih, James D Doecke, Olivier Salvado, Ashley I Bush, Christopher C Rowe, Samuel E Gandy, Colin L Masters
Worldwide there are over 46 million people living with dementia, and this number is expected to double every 20 years reaching about 131 million by 2050. The cost to the community and government health systems, as well as the stress on families and carers is incalculable. Over three decades of research into this disease have been undertaken by several research groups in Australia, including work by our original research group in Western Australia which was involved in the discovery and sequencing of the amyloid-β peptide (also known as Aβ or A4 peptide) extracted from cerebral amyloid plaques...
2018: Journal of Alzheimer's Disease: JAD
Duncan C Miller, Mathew P Martin, Santosh Adhikari, Alfie Brennan, Jane A Endicott, Bernard T Golding, Ian R Hardcastle, Amy Heptinstall, Stephen Hobson, Claire Jennings, Lauren Molyneux, Yvonne Ng, Stephen R Wedge, Martin E M Noble, Celine Cano
ATAD2 is an ATPase that is overexpressed in a variety of cancers and associated with a poor patient prognosis. This protein has been suggested to function as a cofactor for a range of transcription factors, including the proto-oncogene MYC and the androgen receptor. ATAD2 comprises an ATPase domain, implicated in chromatin remodelling, and a bromodomain which allows it to interact with acetylated histone tails. Dissection of the functional roles of these two domains would benefit from the availability of selective, cell-permeable pharmacological probes...
February 22, 2018: Organic & Biomolecular Chemistry
Rebecca Guest, Yvonne Tran, Bamini Gopinath, Ian D Cameron, Ashley Craig
BACKGROUND: Physical injury and psychological disorder following a motor vehicle crash (MVC) is a public health concern. The objective of this research was to determine rates of major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) in adults with MVC-related injury engaged in compensation, and to determine the capacity (e.g. sensitivity and specificity) of two psychometric scales for estimating the presence of MDD and PTSD. METHODS: Participants included 109 adults with MVC-related injury engaged in compensation during 2015 to 2017, in Sydney, Australia...
February 21, 2018: BMC Psychology
Emily C A Goodall, Ashley Robinson, Iain G Johnston, Sara Jabbari, Keith A Turner, Adam F Cunningham, Peter A Lund, Jeffrey A Cole, Ian R Henderson
Transposon-directed insertion site sequencing (TraDIS) is a high-throughput method coupling transposon mutagenesis with short-fragment DNA sequencing. It is commonly used to identify essential genes. Single gene deletion libraries are considered the gold standard for identifying essential genes. Currently, the TraDIS method has not been benchmarked against such libraries, and therefore, it remains unclear whether the two methodologies are comparable. To address this, a high-density transposon library was constructed in Escherichia coli K-12...
February 20, 2018: MBio
Radhika V Seimon, Anthony L Wild-Taylor, Alice A Gibson, Claudia Harper, Sally McClintock, Hamish A Fernando, Michelle S H Hsu, Felipe Q da Luz, Shelley E Keating, Nathan A Johnson, Stuart M Grieve, Tania P Markovic, Ian D Caterson, Nuala M Byrne, Amanda Sainsbury
With obesity being a leading cause of preventable death, it is vital to understand how best to identify individuals with greater risk of metabolic disease, especially those with high visceral adipose tissue (VAT). This study aimed to determine whether three commonly used waist circumference (WC) measurement sites could provide accurate estimations of VAT, as determined by magnetic resonance imaging (MRI), which is a gold standard for measuring VAT, in postmenopausal women with obesity. VAT volume was measured by MRI of the total abdomen in 97 women aged 57...
February 20, 2018: Nutrients
David L Bell, Samantha Garbers, Marina Catallozzi, R Stanley Hum, Meredith Nechitilo, Ian W McKeague, Emilia H Koumans, L Duane House, Susan L Rosenthal, Melanie A Gold
PURPOSE: Despite recent declines, teen unintended pregnancy and sexually transmitted infections in the United States remain at levels higher than comparable nations. Initiatives to prevent teen pregnancy have focused primarily on female adolescents; how to effectively engage young men to reduce their risk of fathering a teen pregnancy has not been well studied. We proposed to adapt an innovative computer-assisted motivational interviewing (CAMI) intervention, originally designed and tested with young women, for use with young men, aged 15-24 years, to reduce their risk of fathering a teen pregnancy...
March 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Rebecca A Musgrave, Rebekah L N Hailes, André Schäfer, Andrew D Russell, Paul J Gates, Ian Manners
We describe two new types of reactivity involving silicon-bridged [1]ferrocenophanes. In an attempt to form a [1]ferrocenophane with a bridging silyl cation, the reaction of sila[1]ferrocenophane [Fe(η-C5H4)2Si(H)TMP] (12) (TMP = 2,2,6,6-tetramethylpiperidyl) towards the hydride-abstraction reagent trityl tetrakis(pentafluorophenyl)borate ([CPh3][B(C6F5)4]) was explored. This yielded the unusual dinuclear species [Fe(η-C5H4)2Si(TMP·H)(η-C5H3)Fe(η-C5H4)Si(H)TMP][B(C6F5)4] [13][B(C6F5)4] in low yield. The formation of [13]+ is proposed to involve abstraction of hydride from the silicon bridge in 12 with subsequent C-H bond cleavage of a cyclopentadienyl group by the resulting electrophilic transient silyl cation intermediate...
February 8, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Jiangping Xu, Hang Zhou, Qing Yu, Ian Manners, Mitchell A Winnik
Nucleated self-assembly in selective solvents of core-crystalline block copolymers (BCPs) is a special case of living supramolecular polymerization, leading to rodlike micelles of controlled and uniform length. For the crystallization-driven self-assembly of PFS-containing BCPs (PFS = polyferrocenyldimethylsilane), the formation of block comicelles by sequential addition of different BCPs is well-established. But there are only a few examples of living copolymerization, the simultaneous addition of pairs of BCPs with different corona-forming chains...
February 5, 2018: Journal of the American Chemical Society
Maddison J Jones, Ian C Dunican, Kevin Murray, Peter Peeling, Brian Dawson, Shona Halson, Joanna Miller, Peter R Eastwood
The 10-min Psychomotor Vigilance Test (PVT-10) is regarded as the gold-standard for assessing vigilant attention following sleep loss; however, other studies have investigated whether shorter versions of the test elicit similar results to the PVT-10. The present study compared the PVT-10 with 3-min (PVT-3) and 5-min (PVT-5) versions of the test in elite female basketball players. Athletes performed all three tests in the morning and evening for seven consecutive days. Response speed (mean reciprocal reaction time; mean 1/RT), number of errors and number of lapses were determined for each test and time point...
January 31, 2018: Journal of Sports Sciences
Harald Ian Muri, Andon Bano, Dag Roar Hjelme
We report on characterization of an optical fiber-based multi-parameter sensor concept combining localized surface plasmon resonance (LSPR) signal and interferometric sensing using a double-clad optical fiber. The sensor consists of a micro-Fabry-Perot in the form of a hemispherical stimuli-responsive hydrogel with immobilized gold nanorods on the facet of a cleaved double-clad optical fiber. The swelling degree of the hydrogel is measured interferometrically using the single-mode inner core, while the LSPR signal is measured using the multi-mode inner cladding...
January 11, 2018: Sensors
Hyunjun Cho, Shailabh Kumar, Daejong Yang, Sagar Vaidyanathan, Kelly Woo, Ian Garcia, Hao J Shue, Youngzoon Yoon, Kevin Ferreri, Hyuck Choo
Label-free optical detection of insulin would allow in vitro assessment of pancreatic cell functions in their natural state and expedite diabetes-related clinical research and treatment; however, no existing method has met these criteria at physiological concentrations. Using spatially uniform 3D gold-nanoparticle sensors, we have demonstrated surface-enhanced Raman sensing of insulin in the secretions from human pancreatic islets under low and high glucose environments without the use of labels such as antibodies or aptamers...
January 26, 2018: ACS Sensors
Matthew Rosenthal, Bin Huang, Nora Katabi, Jocelyn Migliacci, Robert Bryant, Samuel Kaplan, Timothy Blackwell, Snehal Patel, Liying Yang, Zhiheng Pei, Yi-Wei Tang, Ian Ganly
Background: The majority of patients diagnosed with oropharyngeal squamous cell cancer (OPSCC) are due to HPV infection. At present, there are no reliable tests for screening HPV in patients with OPSCC. The objective of this study was to assess the Cobas® HPV Test on oral rinse specimens as an early, non-invasive tool for HPV-related OPSCC. Methods: Oral rinse specimens were collected from 187 patients (45 with OPSCC, 61 with oral cavity SCC (OCSCC) and 81 control patients who had benign or malignant thyroid nodules) treated at MSKCC...
December 12, 2017: Oncotarget
Jie He, Sarah Unser, Ian Bruzas, ReJeana Cary, Zhiwei Shi, Rajesh Mehra, Kenneth Aron, Laura Sagle
A common capping agent for gold nanorods, Cetyl trimethylammonium bromide (CTAB), is particularly problematic for biological studies because of its cytotoxicity. Several procedures have been developed to remove the CTAB from the surface of the gold nanorods, but most are lengthy, involving many steps, and use expensive reagents. Here, we present a simple, one-pot method for the complete removal of CTAB from the surface of gold nanorods, so that particles can be more effectively utilized in biological in vivo studies...
March 1, 2018: Colloids and Surfaces. B, Biointerfaces
Yongle Du, Long Xia, Ami Jo, Richey M Davis, Philippe Bissel, Marion F Ehrich, David G I Kingston
Doxorubicin is an effective and widely used cancer chemotherapeutic agent, but its application is greatly compromised by its cumulative dose-dependent side effect of cardiotoxicity. A gold nanoparticle-based drug delivery system has been designed to overcome this limitation. Five novel thiolated doxorubicin analogs were synthesized and their biological activities evaluated. Two of these analogs and PEG stabilizing ligands were then conjugated to gold nanoparticles, and the resulting Au-Dox constructs were evaluated...
February 21, 2018: Bioconjugate Chemistry
Massimiliano de Zambotti, Aimee Goldstone, Stephanie Claudatos, Ian M Colrain, Fiona C Baker
We evaluated the performance of a consumer multi-sensory wristband (Fitbit Charge 2™), against polysomnography (PSG) in measuring sleep/wake state and sleep stage composition in healthy adults. In-lab PSG and Fitbit Charge 2™ data were obtained from a single overnight recording at the SRI Human Sleep Research Laboratory in 44 adults (19-61 years; 26 women; 25 Caucasian). Participants were screened to be free from mental and medical conditions. Presence of sleep disorders was evaluated with clinical PSG...
December 13, 2017: Chronobiology International
Harald Ian Muri, Dag Roar Hjelme
We report on a new localized surface plasmon resonance (LSPR)-based optical fiber (OF) architecture with a potential in sensor applications. The LSPR-OF system is fabricated by immobilizing gold nanoparticles (GNPs) in a hydrogel droplet polymerized on the fiber end face. This design has several advantages over earlier designs. It dramatically increase the number nanoparticles (NP) available for sensing, it offers precise control over the NP density, and the NPs are positioned in a true 3D aqueous environment...
November 25, 2017: Sensors
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