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https://www.readbyqxmd.com/read/28283744/serial-block-face-scanning-electron-microscopy-applied-to-study-the-trafficking-of-8d3-coated-gold-nanoparticles-at-the-blood-brain-barrier
#1
Itsaso Cabezón, Elisabet Augé, Manel Bosch, Alison J Beckett, Ian A Prior, Carme Pelegrí, Jordi Vilaplana
Due to the physical and physiological properties of the blood-brain barrier (BBB), the transport of neurotherapeutics from blood to brain is still a pharmaceutical challenge. We previously conducted a series of experiments to explore the potential of the anti-transferrin receptor 8D3 monoclonal antibody (mAb) to transport neurotherapeutics across the BBB. In that study, gold nanoparticles (AuNPs) were coated with the 8D3 antibody and administered intravenously to mice. Transmission electron microscopy was used and a two-dimensional (2D) image analysis was performed to detect the AuNPs in the brain capillary endothelial cells (BCECs) and brain parenchyma...
March 10, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28278337/a-proposal-to-redefine-close-surgical-margins-in-squamous-cell-carcinoma-of-the-oral-tongue
#2
Daniella Karassawa Zanoni, Jocelyn C Migliacci, Bin Xu, Nora Katabi, Pablo H Montero, Ian Ganly, Jatin P Shah, Richard J Wong, Ronald A Ghossein, Snehal G Patel
Importance: Resection of the primary tumor with negative margins is the gold standard treatment for squamous cell carcinoma of the oral tongue (SCCOT). A microscopically positive surgical margin is clearly associated with a higher risk for local recurrence, whereas a negative margin has traditionally been defined as greater than 5.0 mm clearance from the tumor, with lesser margins arbitrarily designated as close. The precise cutoff at which the risk for local recurrence with a close margin approximates that of a microscopically positive margin remains unclear...
March 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28268924/modeling-of-pharyngoesophageal-segment-during-tracheoesophageal-phonation-in-total-laryngectomy-patients-with-preliminary-validation
#3
Teng Zhang, Siwei Bai, Ian Cook, Michal Szczesniak, Julia Maclean, Socrates Dokos
For patients with large or recurrent laryngeal cancer, total laryngectomy surgery is usually performed. In the absence of a larynx, tracheoesophageal (TE) voice is the gold standard for alaryngeal phonation. The mechanisms underlying TE voice are unknown, but pharyngoesophageal (PE) segment vibration has been shown to play a key role. The aim of this study was to systematically explore the mechanics of PE segment vibration during TE phonation. A 2D axisymmetric finite-element model with two domains representing the air and PE wall was developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28256823/determination-of-lead-with-a-copper-based-electrochemical-sensor
#4
Wenjing Kang, Xing Pei, Cory A Rusinek, Adam Bange, Erin N Haynes, William R Heineman, Ian Papautsky
This work demonstrates determination of lead (Pb) in surface water samples using a low-cost copper (Cu)-based electrochemical sensor. Heavy metals require careful monitoring due to their toxicity, yet current methods are too complex or bulky for point-of-care (POC) use. Electrochemistry offers a convenient alternative for metal determination, but the traditional electrodes, such as carbon or gold/platinum, are costly and difficult to microfabricate. Our copper-based sensor features a low-cost electrode material-copper-that offers simple fabrication and competitive performance in electrochemical detection...
March 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28227129/modeling-of-pharyngoesophageal-segment-during-tracheoesophageal-phonation-in-total-laryngectomy-patients-with-preliminary-validation
#5
Teng Zhang, Siwei Bai, Ian Cook, Michal Szczesniak, Julia Maclean, Socrates Dokos, Teng Zhang, Siwei Bai, Ian Cook, Michal Szczesniak, Julia Maclean, Socrates Dokos, Siwei Bai, Michal Szczesniak, Socrates Dokos, Ian Cook, Julia Maclean, Teng Zhang
For patients with large or recurrent laryngeal cancer, total laryngectomy surgery is usually performed. In the absence of a larynx, tracheoesophageal (TE) voice is the gold standard for alaryngeal phonation. The mechanisms underlying TE voice are unknown, but pharyngoesophageal (PE) segment vibration has been shown to play a key role. The aim of this study was to systematically explore the mechanics of PE segment vibration during TE phonation. A 2D axisymmetric finite-element model with two domains representing the air and PE wall was developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28185364/enabling-heterogeneous-gold-catalysis-with-patchy-micelles
#6
John R Finnegan, Jessica Gwyther, Ian Manners
Patch works! Patchy block copolymer micelles with a corona consisting of two chemically different patches have been designed for the selective binding of catalytically active nanoparticles. The fabrication of nonwoven supports by electrospinning was combined with crystallization-driven self-assembly for precise control over micelle formation to prepare a new recyclable catalyst platform.
February 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28164013/stenotic-flow-reserve-derived-from-quantitative-coronary-angiography-has-modest-but-incremental-value-in-predicting-functionally-significant-coronary-stenosis-as-evaluated-by-fractional-flow-reserve
#7
Elizabeth L Potter, Colin Machado, Yuvaraj Malaiapan, Om Narayan, Brian S H Ko, Peter J Psaltis, Kiran Munnur, James D Cameron, Ian T Meredith, Dennis Thiam Leong Wong
BACKGROUND: Stenotic flow reserve (SFR) derived from quantitative coronary angiography (QCA) has been correlated with myocardial ischaemia as determined by pharmacological stress echocardiography. However, the diagnostic accuracy of SFR in predicting functionally significant coronary stenosis as assessed by the gold standard, fractional flow reserve (FFR), has not been previously characterised. METHODS: Patients who underwent coronary angiography and FFR assessment between January 2010 and February 2012 in a single tertiary centre were retrospectively assessed...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28135097/ionic-strength-surface-charge-and-packing-density-effects-on-the-properties-of-peptide-self-assembled-monolayers
#8
Norman Leo, Juan Liu, Ian Archbold, Yongan Tang, Xiangqun Zeng
The various environmental parameters of packing density, ionic strength, and solution charge were examined for their effects on the properties of the immobilized peptide mimotope CH19 (CGSGSGSQLGPYELWELSH) that binds with the therapeutic antibody Trastuzumab (Herceptin) on a gold substrate. The immobilization of CH19 onto gold was examined with a quartz crystal microbalance (QCM). The QCM data showed the presence of intermolecular interactions resulting in the increase of viscoelastic properties of the peptide self-assembled monolayer (SAM)...
February 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28056028/assessing-ultrasonography-as-a-diagnostic-tool-for-porcine-cysticercosis
#9
Robert H Flecker, Ian W Pray, Saul J Santivaňez, Viterbo Ayvar, Ricardo Gamboa, Claudio Muro, Luz Maria Moyano, Victor Benavides, Hector H Garcia, Seth E O'Neal
BACKGROUND: Taenia solium inflicts substantial neurologic disease and economic losses on rural communities in many developing nations. "Ring-strategy" is a control intervention that targets treatment of humans and pigs among clusters of households (rings) that surround pigs heavily infected with cysticerci. These pigs are typically identified by examining the animal's tongue for cysts. However, as prevalence decreases in intervened communities, more sensitive methods may be needed to identify these animals and to maintain control pressure...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28040885/gold-nanoparticle-uptake-by-human-derived-macrophages-and-primary-liver-phagocytic-cells-is-dependent-on-phenotype
#10
Sonya A MacParland, Kim M Tsoi, Ben Ouyang, Xue-Zhong Ma, Justin Manuel, Ali Fawaz, Mario A Ostrowski, Benjamin A Alman, Anton Zilman, Warren C W Chan, Ian D McGilvray
A significant challenge to delivering therapeutic doses of nanoparticles to targeted disease sites is the fact that most nanoparticles become trapped in the liver. Liver resident macrophages, or Kupffer cells, are key cells in the hepatic sequestration of nanoparticles. However, the precise role macrophage phenotype plays in nanoparticle uptake is unknown. Here, we show that human macrophage phenotype modulates hard nanoparticle uptake. Using gold nanoparticles, we examined uptake by human monocyte-derived macrophages that had been driven to a "regulatory" M2 phenotype or an "inflammatory" M1 phenotype and found that M2-type macrophages preferentially take up nanoparticles, with a clear spectrum among the subtypes (M2c>M2>M2a>M2b>M1)...
December 31, 2016: ACS Nano
https://www.readbyqxmd.com/read/28005359/cyclin-dependent-kinase-cdk-inhibitors-structure-activity-relationships-and-insights-into-the-cdk-2-selectivity-of-6-substituted-2-arylaminopurines
#11
Christopher R Coxon, Elizabeth Anscombe, Suzannah J Harnor, Mathew P Martin, Benoit Carbain, Bernard T Golding, Ian R Hardcastle, Lisa K Harlow, Svitlana Korolchuk, Christopher J Matheson, David R Newell, Martin E M Noble, Mangaleswaran Sivaprakasam, Susan J Tudhope, David M Turner, Lan Z Wang, Stephen R Wedge, Christopher Wong, Roger J Griffin, Jane A Endicott, Céline Cano
Purines and related heterocycles substituted at C-2 with 4'-sulfamoylanilino and at C-6 with a variety of groups have been synthesized with the aim of achieving selectivity of binding to CDK2 over CDK1. 6-Substituents that favor competitive inhibition at the ATP binding site of CDK2 were identified and typically exhibited 10-80-fold greater inhibition of CDK2 compared to CDK1. Most impressive was 4-((6-([1,1'-biphenyl]-3-yl)-9H-purin-2-yl)amino) benzenesulfonamide (73) that exhibited high potency toward CDK2 (IC50 0...
February 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27988322/a-multi-centre-evaluation-of-eleven-clinically-feasible-brain-pet-mri-attenuation-correction-techniques-using-a-large-cohort-of-patients
#12
Claes N Ladefoged, Ian Law, Udunna Anazodo, Keith St Lawrence, David Izquierdo-Garcia, Ciprian Catana, Ninon Burgos, M Jorge Cardoso, Sebastien Ourselin, Brian Hutton, Inés Mérida, Nicolas Costes, Alexander Hammers, Didier Benoit, Søren Holm, Meher Juttukonda, Hongyu An, Jorge Cabello, Mathias Lukas, Stephan Nekolla, Sibylle Ziegler, Matthias Fenchel, Bjoern Jakoby, Michael E Casey, Tammie Benzinger, Liselotte Højgaard, Adam E Hansen, Flemming L Andersen
AIM: To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal cannot easily be converted into attenuation values, making attenuation correction (AC) in PET/MRI challenging. In order to further improve the current vendor-implemented MR-AC methods for absolute quantification, a number of prototype methods have been proposed in the literature. These can be categorized into three types: template/atlas-based, segmentation-based, and reconstruction-based...
February 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/27983956/increasing-the-accuracy-and-scalability-of-the-immunofluorescence-assay-for-epstein-barr-virus-by-inferring-continuous-titers-from-a-single-sample-dilution
#13
Sherry Meow Peng Goh, Muthukaruppan Swaminathan, Julian U-Ming Lai, Azlinda Anwar, Soh Ha Chan, Ian Cheong
High Epstein Barr Virus (EBV) titers detected by the indirect Immunofluorescence Assay (IFA) are a reliable predictor of Nasopharyngeal Carcinoma (NPC). Despite being the gold standard for serological detection of NPC, the IFA is limited by scaling bottlenecks. Specifically, 5 serial dilutions of each patient sample must be prepared and visually matched by an evaluator to one of 5 discrete titers. Here, we describe a simple method for inferring continuous EBV titers from IFA images acquired from NPC-positive patient sera using only a single sample dilution...
January 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27940650/autopsy-validation-of-123i-fp-cit-dopaminergic-neuroimaging-for-the-diagnosis-of-dlb
#14
Alan J Thomas, Johannes Attems, Sean J Colloby, John T O'Brien, Ian McKeith, Rodney Walker, Lean Lee, David Burn, Debra J Lett, Zuzana Walker
OBJECTIVE: To conduct a validation study of (123)I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane ((123)I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS: Patients >60 years of age with dementia who had undergone (123)I-FP-CIT imaging in research studies and who had donated their brain tissue to the Newcastle Brain Tissue Resource were included. All had structured clinical research assessments, and clinical diagnoses were applied by consensus panels using international diagnostic criteria...
January 17, 2017: Neurology
https://www.readbyqxmd.com/read/27932540/twelve-month-follow-up-on-a-randomised-controlled-trial-of-relaxation-training-for-post-stroke-anxiety
#15
Katherine Golding, Chris Fife-Schaw, Ian Kneebone
OBJECTIVE: To follow up participants in a randomised controlled trial of relaxation training for anxiety after stroke at 12 months. DESIGN: Twelve month follow-up to a randomised controlled trial, in which the control group also received treatment. SETTING: Community. PARTICIPANTS: Fifteen of twenty one original participants with post-stroke anxiety participated in a one year follow-up study. INTERVENTIONS: A self-help autogenic relaxation CD listened to five times a week for one month, immediately in the intervention group and after three months in the control group...
December 8, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27923707/three-dimensional-magnetic-resonance-imaging-quantification-of-glenoid-bone-loss-is-equivalent-to-3-dimensional-computed-tomography-quantification-cadaveric-study
#16
Adam B Yanke, Jason J Shin, Ian Pearson, Bernard R Bach, Anthony A Romeo, Brian J Cole, Nikhil N Verma
PURPOSE: To assess the ability of 3-dimensional (3D) magnetic resonance imaging (MRI, 1.5 and 3 tesla [T]) to quantify glenoid bone loss in a cadaveric model compared with the current gold standard, 3D computed tomography (CT). METHODS: Six cadaveric shoulders were used to create a bone loss model, leaving the surrounding soft tissues intact. The anteroposterior (AP) dimension of the glenoid was measured at the glenoid equator and after soft tissue layer closure the specimen underwent scanning (CT, 1...
December 3, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27905964/what-is-the-optimal-recall-period-for-verbal-autopsies-validation-study-based-on-repeat-interviews-in-three-populations
#17
Peter Serina, Ian Riley, Bernardo Hernandez, Abraham D Flaxman, Devarsetty Praveen, Veronica Tallo, Rohina Joshi, Diozele Sanvictores, Andrea Stewart, Meghan D Mooney, Christopher J L Murray, Alan D Lopez
BACKGROUND: One key contextual feature in Verbal Autopsy (VA) is the time between death and survey administration, or recall period. This study quantified the effect of recall period on VA performance by using a paired dataset in which two VAs were administered for a single decedent. METHODS: This study used information from the Population Health Metrics Research Consortium (PHMRC) Study, which collected VAs for "gold standard" cases where cause of death (COD) was supported by clinical criteria...
October 18, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27890594/an-investigation-of-trends-in-precious-metal-and-copper-content-of-ram-modules-in-weee-implications-for-long-term-recycling-potential
#18
Rhys Gareth Charles, Peter Douglas, Ingrid Liv Hallin, Ian Matthews, Gareth Liversage
Precious metal (PM) and copper content of dynamic-RAM modules placed on the market during 1991-2008 has been analysed by AAS following comminution and acid digestion. Linear regression analysis of compositional data ordered according to sample chronology was used to identify historic temporal trends in module composition resulting from changes in manufacturing practices, and to project future trends for use in more accurate assessment of future recycling potential. DRAM was found to be 'high grade' waste with: stable levels of gold and silver over time; 80% reduction in palladium content during 1991-2008; and 0...
November 24, 2016: Waste Management
https://www.readbyqxmd.com/read/27879522/a-systematic-review-of-completeness-of-reporting-in-randomized-controlled-trials-in-dermatologic-surgery-adherence-to-consort-2010-recommendations
#19
Murad Alam, Mutahir Rauf, Sana Ali, Parth Patel, Daniel I Schlessinger, Matthew R Schaeffer, Simon S Yoo, Kira Minkis, Shang I Brian Jiang, Ian A Maher, Joseph F Sobanko, Todd V Cartee, Emily Poon
BACKGROUND: Randomized controlled trials are the gold standard for comparing safety and effectiveness of surgical interventions. Reporting guidelines are available for conveying the results of such trials. OBJECTIVE: To assess adherence to standard reporting guidelines among randomized controlled trials in dermatologic surgery. MATERIALS AND METHODS: Systematic review. Data source was randomized controlled trials in the journal Dermatologic Surgery, per PubMed search, 1995 to 2014...
December 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27876146/vertical-flow-paper-sers-system-for-therapeutic-drug-monitoring-of-flucytosine-in-serum
#20
Adam G Berger, Stephen M Restaino, Ian M White
A number of life-saving drugs require therapeutic drug monitoring (TDM) for safe and effective use. Currently, however, TDM is performed using sophisticated analytical techniques relegated to central labs, increasing the cost per test and time to answer. Here, using a novel vertical flow membrane system with inkjet-printed surface enhanced Raman sensors, along with a portable spectrometer, we demonstrate a low cost and easy to use device to quantify levels of flucytosine, an antifungal that requires TDM for effective patient care, from undiluted human serum...
January 1, 2017: Analytica Chimica Acta
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