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https://www.readbyqxmd.com/read/28535675/a-novel-liposome-based-surface-enhanced-raman-spectroscopy-sers-substrate
#1
William Lum, Ian R Bruzas, Zohre Gorunmez, Sarah A Unser, Thomas L Beck, Laura B Sagle
Although great strides have been made in recent years towards making highly enhancing surface enhanced Raman spectroscopy (SERS) substrates, the biological compatibility of such substrates remains a crucial problem. To address this issue, liposome-based SERS substrates have been constructed in which the biological probe molecule is encapsulated inside the aqueous liposome compartment, and metallic elements are assembled using the liposome as a scaffold. Thus, the probe molecule is not in contact with the metallic surfaces...
May 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28455279/engaging-patients-and-caregivers-managing-rare-diseases-to-improve-the-methods-of-clinical-guideline-development-a-research-protocol
#2
Dmitry Khodyakov, Kathi Kinnett, Sean Grant, Ann Lucas, Ann Martin, Brian Denger, Holly Peay, Ian Coulter, Arlene Fink
BACKGROUND: Clinical guidelines provide systematically developed recommendations for deciding on appropriate health care options for specific conditions and clinical circumstances. Up until recently, patients and caregivers have rarely been included in the process of developing care guidelines. OBJECTIVE: This project will develop and test a new online method for including patients and their caregivers in this process using Duchenne muscular dystrophy (DMD) care guidelines as an example...
April 28, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28447703/conserved-effects-and-altered-trafficking-of-cetuximab-antibodies-conjugated-to-gold-nanoparticles-with-precise-control-of-their-number-and-orientation
#3
Lorena García-Fernández, Javier Garcia-Pardo, Olivia Tort, Ian Prior, Mathias Brust, Eudald Casals, Julia Lorenzo, Victor F Puntes
Gold nanoparticles (17 nm) have been functionalized with the antiangiogenic monoclonal antibody drug Cetuximab at a well-defined orientation and coverage density of antibodies. Functionalization has been carried out through site-directed chemistry via the selective oxidation of the carbohydrate moiety of antibodies linked to a thiolated hydrazide. A431 tumor cells have been exposed to these conjugates for in vitro evaluation of their effects. In addition to epithelial growth factor receptor blocking, trafficking and signaling alterations were also observed...
May 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28447459/fast-torsional-artificial-muscles-from-niti-twisted-yarns
#4
Seyed M Mirvakili, Ian W Hunter
Torsional artificial muscles made of multiwalled carbon nanotube/niobium nanowire yarns have shown remarkable torsional speed and gravimetric torque. The muscle structure consists of a twisted yarn with half of its length infiltrated with a stimuli-responsive guest material such as paraffin wax. The volumetric expansion of the guest material creates the torsional actuation in the yarn. In the present work, we show that this type of actuation is not unique to wax-infiltrated carbon multiwalled nanotube (MWCNT) or niobium nanowire yarns and that twisted yarn of NiTi alloy fibers also produces fast torsional actuation...
May 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28434640/imaging-guidance-for-transcatheter-aortic-valve-replacement-is-transoesophageal-echocardiography-the-gold-standard
#5
REVIEW
Bo Xu, Philip M Mottram, Siobhan Lockwood, Ian T Meredith
Transcatheter aortic valve replacement (TAVR) is traditionally performed under cardiac imaging guidance. In the early TAVR experience, intra-procedural transoesophageal echocardiography (TOE) is recommended to guide device deployment, in the context of general anaesthesia (GA). Intra-procedural TOE imaging is particularly useful during TAVR deployment as a contrast-saving strategy for patients with renal impairment. Evidence has emerged recently demonstrating that in selected patients, transthoracic echocardiography (TTE) can be used to provide intra-procedural guidance for TAVR...
March 27, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28426059/evolution-of-dealloying-induced-strain-in-nanoporous-gold-crystals
#6
Yu-Chen Karen Chen-Wiegart, Ross Harder, David C Dunand, Ian McNulty
We studied the evolution of dealloying-induced strain along the {111} in a Ag-Au nano-crystal in situ, during formation of nanoporous gold at the initial stage of dealloying using Bragg coherent X-ray diffractive imaging. The strain magnitude with maximum probability in the crystal doubled in 10 s of dealloying. Although formation of nano-pores just began at the surface, the greatest strain is located 60-80 nm deep within the crystal. Dealloying induced a compressive strain in this region, indicating volume shrinkage occurred during pore formation...
May 4, 2017: Nanoscale
https://www.readbyqxmd.com/read/28412526/birth-setting-labour-experience-and-postpartum-psychological-distress
#7
Anna L MacKinnon, Lisa Yang, Nancy Feeley, Ian Gold, Barbara Hayton, Phyllis Zelkowitz
OBJECTIVE: although psychosocial risk factors have been identified for postpartum depression (PPD) and perinatal posttraumatic stress disorder (PTSD), the role of labour- and birth-related factors remains unclear. The present investigation explored the impact of birth setting, subjective childbirth experience, and their interplay, on PPD and postpartum PTSD. METHOD: in this prospective longitudinal cohort study, three groups of women who had vaginal births at a tertiary care hospital, a birthing center, and those transferred from the birthing centre to the tertiary care hospital were compared...
March 31, 2017: Midwifery
https://www.readbyqxmd.com/read/28406898/spatial-relationship-between-taenia-solium-tapeworm-carriers-and-necropsy-cyst-burden-in-pigs
#8
Ian W Pray, Viterbo Ayvar, Ricardo Gamboa, Claudio Muro, Luz M Moyano, Victor Benavides, Robert H Flecker, Hector H Garcia, Seth E O'Neal
BACKGROUND: Taenia solium, a parasite that affects humans and pigs, is the leading cause of preventable epilepsy in the developing world. Geographic hotspots of pigs testing positive for serologic markers of T. solium exposure have been observed surrounding the locations of human tapeworm carriers. This clustered pattern of seropositivity in endemic areas formed the basis for geographically targeted control interventions, which have been effective at reducing transmission. In this study, we further explore the spatial relationship between human tapeworm carriers and infected pigs using necroscopic examination as a quantitative gold-standard diagnostic to detect viable T...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28383028/3d-lattice-distortions-and-defect-structures-in-ion-implanted-nano-crystals
#9
Felix Hofmann, Edmund Tarleton, Ross J Harder, Nicholas W Phillips, Pui-Wai Ma, Jesse N Clark, Ian K Robinson, Brian Abbey, Wenjun Liu, Christian E Beck
Focussed Ion Beam (FIB) milling is a mainstay of nano-scale machining. By manipulating a tightly focussed beam of energetic ions, often gallium (Ga(+)), FIB can sculpt nanostructures via localised sputtering. This ability to cut solid matter on the nano-scale revolutionised sample preparation across the life, earth and materials sciences. Despite its widespread usage, detailed understanding of the FIB-induced structural damage, intrinsic to the technique, remains elusive. Here we examine the defects caused by FIB in initially pristine objects...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28362079/role-of-defects-and-surface-states-in-the-carrier-transport-and-nonlinearity-of-the-diode-characteristics-in-pbs-zno-quantum-dot-solar-cells
#10
Y Cheng, M C D Whitaker, R Makkia, S Cocklin, V R Whiteside, L A Bumm, E Adcock-Smith, K P Roberts, P Hari, I R Sellers
The roles of bulk surface states and interfacial defects are probed experimentally using a combination of current-voltage, capacitance-voltage, and impedance measurements. The critical importance of the quality of both the film and interfaces is evident in current-voltage measurements where shunting and interface states result in large dark currents and the subsequent loss of Jsc. These properties are shown to be critically related to the nature and role of the PbS QD interface with the (nominally) ohmic gold contact...
April 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28283744/serial-block-face-scanning-electron-microscopy-applied-to-study-the-trafficking-of-8d3-coated-gold-nanoparticles-at-the-blood-brain-barrier
#11
Itsaso Cabezón, Elisabet Augé, Manel Bosch, Alison J Beckett, Ian A Prior, Carme Pelegrí, Jordi Vilaplana
Due to the physical and physiological properties of the blood-brain barrier (BBB), the transport of neurotherapeutics from blood to brain is still a pharmaceutical challenge. We previously conducted a series of experiments to explore the potential of the anti-transferrin receptor 8D3 monoclonal antibody (mAb) to transport neurotherapeutics across the BBB. In that study, gold nanoparticles (AuNPs) were coated with the 8D3 antibody and administered intravenously to mice. Transmission electron microscopy was used and a two-dimensional (2D) image analysis was performed to detect the AuNPs in the brain capillary endothelial cells (BCECs) and brain parenchyma...
March 10, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28278337/a-proposal-to-redefine-close-surgical-margins-in-squamous-cell-carcinoma-of-the-oral-tongue
#12
Daniella Karassawa Zanoni, Jocelyn C Migliacci, Bin Xu, Nora Katabi, Pablo H Montero, Ian Ganly, Jatin P Shah, Richard J Wong, Ronald A Ghossein, Snehal G Patel
Importance: Resection of the primary tumor with negative margins is the gold standard treatment for squamous cell carcinoma of the oral tongue (SCCOT). A microscopically positive surgical margin is clearly associated with a higher risk for local recurrence, whereas a negative margin has traditionally been defined as greater than 5.0 mm clearance from the tumor, with lesser margins arbitrarily designated as close. The precise cutoff at which the risk for local recurrence with a close margin approximates that of a microscopically positive margin remains unclear...
March 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28268924/modeling-of-pharyngoesophageal-segment-during-tracheoesophageal-phonation-in-total-laryngectomy-patients-with-preliminary-validation
#13
Teng Zhang, Siwei Bai, Ian Cook, Michal Szczesniak, Julia Maclean, Socrates Dokos
For patients with large or recurrent laryngeal cancer, total laryngectomy surgery is usually performed. In the absence of a larynx, tracheoesophageal (TE) voice is the gold standard for alaryngeal phonation. The mechanisms underlying TE voice are unknown, but pharyngoesophageal (PE) segment vibration has been shown to play a key role. The aim of this study was to systematically explore the mechanics of PE segment vibration during TE phonation. A 2D axisymmetric finite-element model with two domains representing the air and PE wall was developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28256823/determination-of-lead-with-a-copper-based-electrochemical-sensor
#14
Wenjing Kang, Xing Pei, Cory A Rusinek, Adam Bange, Erin N Haynes, William R Heineman, Ian Papautsky
This work demonstrates determination of lead (Pb) in surface water samples using a low-cost copper (Cu)-based electrochemical sensor. Heavy metals require careful monitoring due to their toxicity, yet current methods are too complex or bulky for point-of-care (POC) use. Electrochemistry offers a convenient alternative for metal determination, but the traditional electrodes, such as carbon or gold/platinum, are costly and difficult to microfabricate. Our copper-based sensor features a low-cost electrode material-copper-that offers simple fabrication and competitive performance in electrochemical detection...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28227129/modeling-of-pharyngoesophageal-segment-during-tracheoesophageal-phonation-in-total-laryngectomy-patients-with-preliminary-validation
#15
Teng Zhang, Siwei Bai, Ian Cook, Michal Szczesniak, Julia Maclean, Socrates Dokos, Teng Zhang, Siwei Bai, Ian Cook, Michal Szczesniak, Julia Maclean, Socrates Dokos, Siwei Bai, Michal Szczesniak, Socrates Dokos, Ian Cook, Julia Maclean, Teng Zhang
For patients with large or recurrent laryngeal cancer, total laryngectomy surgery is usually performed. In the absence of a larynx, tracheoesophageal (TE) voice is the gold standard for alaryngeal phonation. The mechanisms underlying TE voice are unknown, but pharyngoesophageal (PE) segment vibration has been shown to play a key role. The aim of this study was to systematically explore the mechanics of PE segment vibration during TE phonation. A 2D axisymmetric finite-element model with two domains representing the air and PE wall was developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28185364/enabling-heterogeneous-gold-catalysis-with-patchy-micelles
#16
John R Finnegan, Jessica Gwyther, Ian Manners
Patch works! Patchy block copolymer micelles with a corona consisting of two chemically different patches have been designed for the selective binding of catalytically active nanoparticles. The fabrication of nonwoven supports by electrospinning was combined with crystallization-driven self-assembly for precise control over micelle formation to prepare a new recyclable catalyst platform.
February 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28164013/stenotic-flow-reserve-derived-from-quantitative-coronary-angiography-has-modest-but-incremental-value-in-predicting-functionally-significant-coronary-stenosis-as-evaluated-by-fractional-flow-reserve
#17
Elizabeth L Potter, Colin Machado, Yuvaraj Malaiapan, Om Narayan, Brian S H Ko, Peter J Psaltis, Kiran Munnur, James D Cameron, Ian T Meredith, Dennis Thiam Leong Wong
BACKGROUND: Stenotic flow reserve (SFR) derived from quantitative coronary angiography (QCA) has been correlated with myocardial ischaemia as determined by pharmacological stress echocardiography. However, the diagnostic accuracy of SFR in predicting functionally significant coronary stenosis as assessed by the gold standard, fractional flow reserve (FFR), has not been previously characterised. METHODS: Patients who underwent coronary angiography and FFR assessment between January 2010 and February 2012 in a single tertiary centre were retrospectively assessed...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28135097/ionic-strength-surface-charge-and-packing-density-effects-on-the-properties-of-peptide-self-assembled-monolayers
#18
Norman Leo, Juan Liu, Ian Archbold, Yongan Tang, Xiangqun Zeng
The various environmental parameters of packing density, ionic strength, and solution charge were examined for their effects on the properties of the immobilized peptide mimotope CH19 (CGSGSGSQLGPYELWELSH) that binds with the therapeutic antibody Trastuzumab (Herceptin) on a gold substrate. The immobilization of CH19 onto gold was examined with a quartz crystal microbalance (QCM). The QCM data showed the presence of intermolecular interactions resulting in the increase of viscoelastic properties of the peptide self-assembled monolayer (SAM)...
February 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28056028/assessing-ultrasonography-as-a-diagnostic-tool-for-porcine-cysticercosis
#19
Robert H Flecker, Ian W Pray, Saul J Santivaňez, Viterbo Ayvar, Ricardo Gamboa, Claudio Muro, Luz Maria Moyano, Victor Benavides, Hector H Garcia, Seth E O'Neal
BACKGROUND: Taenia solium inflicts substantial neurologic disease and economic losses on rural communities in many developing nations. "Ring-strategy" is a control intervention that targets treatment of humans and pigs among clusters of households (rings) that surround pigs heavily infected with cysticerci. These pigs are typically identified by examining the animal's tongue for cysts. However, as prevalence decreases in intervened communities, more sensitive methods may be needed to identify these animals and to maintain control pressure...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28040885/phenotype-determines-nanoparticle-uptake-by-human-macrophages-from-liver-and-blood
#20
Sonya A MacParland, Kim M Tsoi, Ben Ouyang, Xue-Zhong Ma, Justin Manuel, Ali Fawaz, Mario A Ostrowski, Benjamin A Alman, Anton Zilman, Warren C W Chan, Ian D McGilvray
A significant challenge to delivering therapeutic doses of nanoparticles to targeted disease sites is the fact that most nanoparticles become trapped in the liver. Liver-resident macrophages, or Kupffer cells, are key cells in the hepatic sequestration of nanoparticles. However, the precise role that the macrophage phenotype plays in nanoparticle uptake is unknown. Here, we show that the human macrophage phenotype modulates hard nanoparticle uptake. Using gold nanoparticles, we examined uptake by human monocyte-derived macrophages that had been driven to a "regulatory" M2 phenotype or an "inflammatory" M1 phenotype and found that M2-type macrophages preferentially take up nanoparticles, with a clear hierarchy among the subtypes (M2c > M2 > M2a > M2b > M1)...
March 28, 2017: ACS Nano
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