keyword
MENU ▼
Read by QxMD icon Read
search

planar cell polarity

keyword
https://www.readbyqxmd.com/read/28500339/a-role-for-core-planar-polarity-proteins-in-cell-contact-mediated-orientation-of-planar-cell-division-across-the-mammalian-embryonic-skin
#1
Fazal Oozeer, Laura L Yates, Charlotte Dean, Caroline J Formstone
The question of how cell division orientation is determined is fundamentally important for understanding tissue and organ shape in both healthy or disease conditions. Here we provide evidence for cell contact-dependent orientation of planar cell division in the mammalian embryonic skin. We propose a model where the core planar polarity proteins Celsr1 and Frizzled-6 (Fz6) communicate the long axis orientation of interphase basal cells to neighbouring basal mitoses so that they align their horizontal division plane along the same axis...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28500065/loss-of-mpdz-impairs-ependymal-cell-integrity-leading-to-perinatal-onset-hydrocephalus-in-mice
#2
Anja Feldner, M Gordian Adam, Fabian Tetzlaff, Iris Moll, Dorde Komljenovic, Felix Sahm, Tobias Bäuerle, Hiroshi Ishikawa, Horst Schroten, Thomas Korff, Ilse Hofmann, Hartwig Wolburg, Andreas von Deimling, Andreas Fischer
Hydrocephalus is a common congenital anomaly. LCAM1 and MPDZ (MUPP1) are the only known human gene loci associated with non-syndromic hydrocephalus. To investigate functions of the tight junction-associated protein Mpdz, we generated mouse models. Global Mpdz gene deletion or conditional inactivation in Nestin-positive cells led to formation of supratentorial hydrocephalus in the early postnatal period. Blood vessels, epithelial cells of the choroid plexus, and cilia on ependymal cells, which line the ventricular system, remained morphologically intact in Mpdz-deficient brains...
May 12, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28488382/neuron-specific-knockdown-of-the-drosophila-fat-induces-reduction-of-life-span-deficient-locomotive-ability-shortening-of-motoneuron-terminal-branches-and-defects-in-axonal-targeting
#3
Aya Nakamura, Ryo Tanaka, Kazushige Morishita, Hideki Yoshida, Yujiro Higuchi, Hiroshi Takashima, Masamitsu Yamaguchi
Mutations in FAT4 gene, one of the human FAT family genes, have been identified in Van Maldergem syndrome (VMS) and Hennekam lymphangiectasia-lymphedema syndrome (HS). The FAT4 gene encodes a large protein with extracellular cadherin repeats, EGF-like domains and Laminin G-like domains. FAT4 plays a role in tumor suppression and planar cell polarity. Drosophila contains a human FAT4 homologue, fat. Drosophila fat has been mainly studied with Drosophila eye and wing systems. Here, we specially knocked down Drosophila fat in nerve system...
May 9, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28481871/suppression-of-planar-cell-polarity-signaling-and-migration-in-glioblastoma-by-nrdp1-mediated-dvl-polyubiquitination
#4
J H Wald, J Hatakeyama, I Printsev, A Cuevas, W H D Fry, M J Saldana, K VanderVorst, A Rowson-Hodel, J M Angelastro, C Sweeney, K L Carraway Rd
The lethality of the aggressive brain tumor glioblastoma multiforme (GBM) results in part from its strong propensity to invade surrounding normal brain tissue. Although oncogenic drivers such as epidermal growth factor receptor activation and Phosphatase and Tensin homolog inactivation are thought to promote the motility and invasiveness of GBM cells via phosphatidylinostitol 3-kinase activation, other unexplored mechanisms may also contribute to malignancy. Here we demonstrate that several components of the planar cell polarity (PCP) arm of non-canonical Wnt signaling including VANGL1, VANGL2 and FZD7 are transcriptionally upregulated in glioma and correlate with poorer patient outcome...
May 8, 2017: Oncogene
https://www.readbyqxmd.com/read/28481497/charge-transfer-states-in-organic-solar-cells-understanding-the-impact-of-polarization-delocalization-and-disorder
#5
Zilong Zheng, Naga Rajesh Tummala, Yao-Tsung Fu, Veaceslav Coropceanu, Jean-Luc Brédas
We investigate the impact of electronic polarization, charge delocalization, and energetic disorder on the charge-transfer (CT) states formed at a planar C60/pentacene interface. The ability to examine large complexes containing up to seven pentacene molecules and three C60 molecules allows us to take explicitly into account the electronic polarization effects. These complexes are extracted from a bilayer architecture modeled by molecular dynamics simulations and evaluated by means of electronic-structure calculations based on long-range-separated functionals (ωB97XD and BNL) with optimized range-separation parameters...
May 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28474393/dynamic-1-h-imaging-of-hyperpolarized-1-13-c-lactate-in-vivo-using-a-reverse-inept-experiment
#6
Jiazheng Wang, Felix Kreis, Alan J Wright, Richard L Hesketh, Malcolm H Levitt, Kevin M Brindle
PURPOSE: Dynamic magnetic resonance spectroscopic imaging of hyperpolarized (13) C-labeled cell substrates has enabled the investigation of tissue metabolism in vivo. Currently observation of these hyperpolarized substrates is limited mainly to (13) C detection. We describe here an imaging pulse sequence that enables proton observation by using polarization transfer from the hyperpolarized (13) C nucleus to spin-coupled protons. METHODS: The pulse sequence transfers (13) C hyperpolarization to (1) H using a modified reverse insensitive nuclei enhanced by polarization transfer (INEPT) sequence that acquires a fully refocused echo...
May 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28465336/segga-a-toolset-for-rapid-automated-analysis-of-epithelial-cell-polarity-and-dynamics
#7
Dene L Farrell, Ori Weitz, Marcelo O Magnasco, Jennifer A Zallen
Epithelial remodeling determines the structure of many organs in the body through changes in cell shape, polarity and behavior and is a major area of study in developmental biology. Accurate and high-throughput methods are necessary to systematically analyze epithelial organization and dynamics at single-cell resolution. We developed SEGGA, an easy-to-use software for automated image segmentation, cell tracking and quantitative analysis of cell shape, polarity and behavior in epithelial tissues. SEGGA is free, open source, and provides a full suite of tools that allow users with no prior computational expertise to independently perform all steps of automated image segmentation, semi-automated user-guided error correction, and data analysis...
May 1, 2017: Development
https://www.readbyqxmd.com/read/28459465/intu-is-essential-for-oncogenic-hh-signaling-through-regulating-primary-cilia-formation-in-basal-cell-carcinoma
#8
N Yang, E L-H Leung, C Liu, L Li, T Eguether, X-J Jun Yao, E C Jones, D A Norris, A Liu, R A Clark, D R Roop, G J Pazour, K R Shroyer, J Chen
Inturned (INTU), a cilia and planar polarity effector, performs prominent ciliogenic functions during morphogenesis, such as in the skin. INTU is expressed in adult tissues but its role in tissue maintenance is unknown. Here, we report that the expression of the INTU gene is aberrantly elevated in human basal cell carcinoma (BCC), coinciding with increased primary cilia formation and activated hedgehog (Hh) signaling. Disrupting Intu in an oncogenic mutant Smo (SmoM2)-driven BCC mouse model prevented the formation of BCC through suppressing primary cilia formation and Hh signaling, suggesting that Intu performs a permissive role during BCC formation...
May 1, 2017: Oncogene
https://www.readbyqxmd.com/read/28454767/emergence-of-tissue-shape-changes-from-collective-cell-behaviours
#9
REVIEW
Frank Jülicher, Suzanne Eaton
Anyone watching a movie of embryonic development immediately appreciates the importance of morphogenetic movements and cell flows that reshape tissue. Dynamic tissue shape changes are genetically choreographed, but their execution is essentially a mechanical event. How the interplay between genetics and tissue mechanics controls tissue shape is a fundamental question. Key insights into this problem have emerged from studies in different model organisms as well as in cultured epithelia. These studies have revealed how gene expression patterns can generate patterns of planar cell polarity that orient cellular force generation and give rise to anisotropic mechanical properties of cells and tissues...
April 25, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28441532/pcp-and-sax-3-robo-pathways-cooperate-to-regulate-convergent-extension-based-nerve-cord-assembly-in-c-%C3%A2-elegans
#10
Pavak K Shah, Matthew R Tanner, Ismar Kovacevic, Aysha Rankin, Teagan E Marshall, Nathaniel Noblett, Nhan Nguyen Tran, Tony Roenspies, Jeffrey Hung, Zheqian Chen, Cristina Slatculescu, Theodore J Perkins, Zhirong Bao, Antonio Colavita
Formation and resolution of multicellular rosettes can drive convergent extension (CE) type cell rearrangements during tissue morphogenesis. Rosette dynamics are regulated by both planar cell polarity (PCP)-dependent and -independent pathways. Here we show that CE is involved in ventral nerve cord (VNC) assembly in Caenorhabditis elegans. We show that a VANG-1/Van Gogh and PRKL-1/Prickle containing PCP pathway and a Slit-independent SAX-3/Robo pathway cooperate to regulate, via rosette intermediaries, the intercalation of post-mitotic neuronal cell bodies during VNC formation...
April 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28441524/sequential-rosettes-drive-c-%C3%A2-elegans-ventral-nerve-cord-assembly
#11
Martha C Soto
Planar cell polarity (PCP) signaling orients developmental events in vertebrates and invertebrates, including convergent extension (CE). In this issue of Development Cell, Shah and Tanner et al. (2017) report that ROBO/SAX-3 signaling acts in parallel with PCP signaling to drive the CE required for ventral nerve cord assembly in C. elegans.
April 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28433748/the-repertoire-of-epithelial-morphogenesis-on-display-progressive-elaboration-of-drosophila-egg-structure
#12
REVIEW
Juan Carlos Duhart, Travis T Parsons, Laurel A Raftery
Epithelial structures are foundational for tissue organization in all metazoans. Sheets of epithelial cells form lateral adhesive junctions and acquire apico-basal polarity perpendicular to the surface of the sheet. Genetic analyses in the insect model, Drosophila melanogaster, have greatly advanced our understanding of how epithelial organization is established, and how it is modulated during tissue morphogenesis. Major insights into collective cell migrations have come from analyses of morphogenetic movements within the adult follicular epithelium that cooperates with female germ cells to build a mature egg...
April 19, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28427201/wnt5a-planar-cell-polarity-signaling-pathway-in-urothelial-carcinoma-a-potential-prognostic-biomarker
#13
Mark Saling, Jordan K Duckett, Ian Ackers, Karen Coschigano, Scott Jenkinson, Ramiro Malgor
Bladder cancer is the fourth most common cancer in men and the most common malignancy of the urinary tract. Bladder cancers detected at an early stage have a very high five-year survival rate, but when detected after local metastasis the rate is only about 50%. Our group recently reported a positive correlation between the expression of Wnt5a, a member of the Wnt proteins family, and histopathological grade and stage of urothelial carcinoma (UC). The objective of this study was to analyze UC cases reported in Athens, Ohio and investigate the major components of Wnt5a / planar cell polarity (PCP) signaling pathway in UC human tissue samples and UC cell lines...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423716/oncogenic-features-of-neuromedin-u-in-breast-cancer-are-associated-with-nmur2-expression-involving-crosstalk-with-members-of-the-wnt-signaling-pathway
#14
Stefan Garczyk, Natalie Klotz, Sabrina Szczepanski, Bernd Denecke, Wiebke Antonopoulos, Saskia von Stillfried, Ruth Knüchel, Michael Rose, Edgar Dahl
Neuromedin U (NMU) has been shown driving the progression of various tumor entities, including breast cancer. However, the expression pattern of NMU and its receptors in breast cancer tissues as well as systematic insight into mechanisms and downstream targets of the NMU-driven signaling pathways are still elusive. Here, NMU expression was found up-regulated in all breast cancer subtypes when compared to healthy breast tissue. Using an in silico dataset comprising 1,195 samples, high NMU expression was identified as an indicator of poor outcome in breast tumors showing strong NMUR2 expression...
March 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28420671/ptk7-localization-and-protein-stability-is-affected-by-canonical-wnt-ligands
#15
Hanna Berger, Marlen Breuer, Hanna Peradziryi, Martina Podleschny, Ralf Jacob, Annette Borchers
PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor with important roles in embryonic development and disease. Originally identified as a gene upregulated in colon cancer it was later shown to regulate planar cell polarity (PCP) and directional cell movement. PTK7 is a Wnt co-receptor, however its role in Wnt signaling remains controversial. Here, we find evidence that place PTK7 at the intersection of canonical and non-canonical Wnt signaling pathways. In presence of canonical Wnt ligands PTK7 is subject to caveolin-mediated endocytosis, while it is unaffected by non-canonical Wnt ligands...
April 18, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28419933/planar-polarized-contractile-actomyosin-networks-in-dynamic-tissue-morphogenesis
#16
REVIEW
Daiki Umetsu, Erina Kuranaga
The complex shapes of animal bodies are constructed through a sequence of simple physical interactions of constituent cells. Mechanical forces generated by cellular activities, such as division, death, shape change and rearrangement, drive tissue morphogenesis. By confining assembly or disassembly of actomyosin networks within the three-dimensional space of the cell, cells can localize forces to induce tissue deformation. Tissue-scale morphogenesis emerges from a collective behavior of cells that coordinates the force generation in space and time...
April 15, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28409313/extracellular-regulation-of-the-mitotic-spindle-and-fate-determinants-driving-asymmetric-cell-division
#17
Prestina Smith, Mark Azzam, Lindsay Hinck
Stem cells use mode of cell division, symmetric (SCD) versus asymmetric (ACD), to balance expansion with self-renewal and the generation of daughter cells with different cell fates. Studies in model organisms have identified intrinsic mechanisms that govern this process, which involves partitioning molecular components between daughter cells, frequently through the regulation of the mitotic spindle. Research performed in vertebrate tissues is revealing both conservation of these intrinsic mechanisms and crucial roles for extrinsic cues in regulating the frequency of these divisions...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28407839/-effect-of-histone-acetylation-deacetylation-imbalances-on-key-gene-of-planar-cell-polarity-pathway
#18
Hong-Yu Duan, Yi Zhang, Kai-Yu Zhou, Chuan Wang, DA-Jian Qiu, Yi-Min Hua
OBJECTIVE: To investigate the effect of histone acetylation/deacetylation imbalances on embryonic hearts of mice and its effect on key genes of planar cell polarity (PCP) pathway-Vangl2, Scrib and Rac1 in H9C2 cells. METHODS: Forty pregnant C57/B6 mice were randomly assigned into three groups: blank group (n=10), vehicle group (n=10), and valproic acid (VPA)-treated group (n=20). In the VPA-treated group, VPA, a histone deacetylase (HDAC) inhibitor, was administered to each individual dam intraperitoneally at a single dose of 700 mg/kg on embryonic day 10...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28384160/a-wnt-planar-polarity-pathway-instructs-neurite-branching-by-restricting-f-actin-assembly-through-endosomal-signaling
#19
Chun-Hao Chen, Chun-Wei He, Chien-Po Liao, Chun-Liang Pan
Spatial arrangement of neurite branching is instructed by both attractive and repulsive cues. Here we show that in C. elegans, the Wnt family of secreted glycoproteins specify neurite branching sites in the PLM mechanosensory neurons. Wnts function through MIG-1/Frizzled and the planar cell polarity protein (PCP) VANG-1/Strabismus/Vangl2 to restrict the formation of F-actin patches, which mark branching sites in nascent neurites. We find that VANG-1 promotes Wnt signaling by facilitating Frizzled endocytosis and genetically acts in a common pathway with arr-1/β-arrestin, whose mutation results in defective PLM branching and F-actin patterns similar to those in the Wnt, mig-1 or vang-1 mutants...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28377456/a-role-for-planar-cell-polarity-during-early-endoderm-morphogenesis
#20
Lee B Miles, Takamasa Mizoguchi, Yutaka Kikuchi, Heather Verkade
The zebrafish endoderm begins to develop at gastrulation stages as a monolayer of cells. The behaviour of the endoderm during gastrulation stages is well understood. However, knowledge of the morphogenic movements of the endoderm during somitogenesis stages, as it forms a mesenchymal rod, is lacking. Here we characterise endodermal development during somitogenesis stages, and describe the morphogenic movements as the endoderm transitions from a monolayer of cells into a mesenchymal endodermal rod. We demonstrate that, unlike the overlying mesoderm, endodermal cells are not polarised during their migration to the midline at early somitogenesis stages...
May 15, 2017: Biology Open
keyword
keyword
47969
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"