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https://www.readbyqxmd.com/read/28431823/sleepiness-and-activity-in-heart-failure-patients-with-reduced-ejection-fraction-and-central-sleep-disordered-breathing
#1
Angela Atalla, Thomas W Carlisle, Anita K Simonds, Martin R Cowie, Mary J Morrell
OBJECTIVE: Patients with heart failure (HF) and sleep disordered breathing (SDB) are typically not sleepy, unlike patients without heart failure. Previous work in HF patients with obstructive SDB suggested that sleepiness was associated with a reduction in daytime activity. The consequences of predominately central SDB on sleepiness in HF are less well understood. The aim of this study was to test the hypothesis that subjective sleepiness is associated with reduced daytime activity in HF patients with central SDB, compared to those without SDB...
January 23, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28421375/obstructive-sleep-apnea-increases-the-risk-of-cardiac-events-after-percutaneous-coronary-intervention-a-meta-analysis-of-prospective-cohort-studies
#2
REVIEW
Hua Qu, Ming Guo, Ying Zhang, Da-Zhuo Shi
PURPOSE: Recent studies have shown an association between obstructive sleep apnea (OSA) and coronary artery disease; however, the association between OSA and cardiac outcomes in patients after percutaneous coronary intervention (PCI) remains undetermined. METHODS: PubMed, EMBASE, and CENTRAL were searched from inception to July 2016 for cohort studies that followed up with patients after PCI, and evaluated their overnight sleep patterns within 1 month for major adverse cardiac events (MACEs) as primary outcomes including cardiac death, non-fatal myocardial infarction (MI), and coronary revascularization and secondary outcomes including re-admission for heart failure and stroke...
April 18, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28417254/whom-are-we-treating-with-adaptive-servo-ventilation-a-clinical-post-hoc-analysis
#3
Maximilian V Malfertheiner, C Lerzer, L Kolb, K Heider, F Zeman, F Gfüllner, L S Maier, M Pfeifer, M Arzt
BACKGROUND: Recent evidence has shown that adaptive servo-ventilation (ASV) is contraindicated in patients with predominant central sleep apnea (CSA) and reduced left ventricular ejection fraction (LVEF ≤45%). The objective of this study was to assess the clinical usage of ASV in patients at the time-point of the release of a safety warning by type of SDB, breathing pattern and LVEF. METHODS: Patients of a cardiac and a respirology sleep center, both in Germany, who received ASV therapy were contacted between May and October 2015...
April 17, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28416405/development-validation-and-assessment-of-an-ischemic-stroke-or-transient-ischemic-attack-specific-prediction-tool-for-obstructive-sleep-apnea
#4
Jason J Sico, H Klar Yaggi, Susan Ofner, John Concato, Charles Austin, Jared Ferguson, Li Qin, Lauren Tobias, Stanley Taylor, Carlos A Vaz Fragoso, Vincent McLain, Linda S Williams, Dawn M Bravata
BACKGROUND: Screening instruments for obstructive sleep apnea (OSA), as used routinely to guide clinicians regarding patient referral for polysomnography (PSG), rely heavily on symptomatology. We sought to develop and validate a cerebrovascular disease-specific OSA prediction model less reliant on symptomatology, and to compare its performance with commonly used screening instruments within a population with ischemic stroke or transient ischemic attack (TIA). METHODS: Using data on demographic factors, anthropometric measurements, medical history, stroke severity, sleep questionnaires, and PSG from 2 independently derived, multisite, randomized trials that enrolled patients with stroke or TIA, we developed and validated a model to predict the presence of OSA (i...
April 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28408965/phospholipase-c-related-catalytically-inactive-protein-can-regulate-obesity-a-state-of-peripheral-inflammation
#5
REVIEW
Yosuke Yamawaki, Kana Oue, Satomi Shirawachi, Satoshi Asano, Kae Harada, Takashi Kanematsu
Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol...
February 2017: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28408467/isolated-mild-sleep-associated-hypoventilation-in-children-with-down-syndrome
#6
Wai Wong, Dennis Rosen
INTRODUCTION: Children with Down syndrome (DS) have a high incidence of obstructive sleep apnea (OSA) that is often associated with hypoventilation. Little is known, however, about the prevalence of sleep-associated hypoventilation independent of OSA in these children. METHODS: Retrospective chart review of all children with DS under 18 years of age undergoing polysomnography at a tertiary care paediatric hospital during a 2-year period. Exclusion criteria were as follow: those requiring oxygen or positive-pressure ventilation; with tracheostomy, baseline hypoxia, unrepaired cyanotic heart disease, pulmonary hypertension, and cerebral palsy; or OSA with >5 obstructions/hour...
April 13, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28394772/obstructive-sleep-apnea-increases-systolic-and-diastolic-blood-pressure-variability-in-hypertensive-patients
#7
Jing Shi, Jingyan Piao, Bin Liu, Yujiao Pan, Yongtai Gong, Xianzhu Deng, Weiyan Sun, Shuang Lu, Yue Li
OBJECTIVE: Obstructive sleep apnea (OSA) has been identified as the most common secondary contributing factor for the development and worsening of hypertension. However, the underlying relationships between blood pressure variability (BPV) and OSA are still not very clear. Therefore, we investigated the influences of OSA on BPV in hypertensive patients and explored the potential pathophysiologic mechanisms. PARTICIPANTS AND METHODS: Ambulatory blood pressure (BP) monitoring was carried out and polysomnography was performed to detect sleep apnea...
April 7, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28392039/effect-of-arterial-puncture-on-ventilation
#8
Ashima Synghal Sahni, Hemil Gonzalez, Aiman Tulaimat
BACKGROUND: Clinicians frequently assume that during arterial puncture for measuring arterial blood gases patients hyperventilate from pain and anxiety. This assumption leads clinicians to falsely interpret a PaCO2 and pH near the upper limit of normal as a chronic respiratory acidosis corrected by an acute respiratory alkalosis. OBJECTIVE: Determine if participants hyperventilate during arterial puncture from pain and anxiety. METHODS: We recruited participants from a pulmonary function laboratory referred for arterial blood gas measurement...
April 6, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28362813/a-novel-adjustable-automated-system-for-inducing-chronic-intermittent-hypoxia-in-mice
#9
Dora Polšek, Marcel Bago, Marija Živaljić, Ivana Rosenzweig, Zsombor Lacza, Srećko Gajović
BACKGROUND: Sleep apnea is a chronic, widely underdiagnosed condition characterized by disruption of sleep architecture and intermittent hypoxia due to short cessations of breathing. It is a major independent risk factor for myocardial infarction, congestive heart failure and stroke as well as one of the rare modifiable risk factors for Alzheimer's Dementia. Reliable animal disease models are needed to understand the link between sleep apnea and the various clinically linked disorders...
2017: PloS One
https://www.readbyqxmd.com/read/28362475/the-genetic-basis-of-obesity-complications
#10
Katarzyna Skrypnik, Joanna Suliburska, Damian Skrypnik, Łukasz Pilarski, Julita Reguła, Paweł Bogdański
Intensive research is currently being performed into the genetic background of excess body mass compli- cations such as diabetes, cardiovascular disorders, especially atherosclerosis and coronary heart disease. Chronic inflammation is an important process in the pathogenesis of obesity, wherein there is an aberrant ex- pression of genes encoding adipokines. Visceral tissue is characterized by a higher expression and secretion of interleukin-8, interleukin-1ß and plasminogen activator inhibitor 1 in the subcutaneous tissue secretion of leptin prevails...
January 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28338434/coexistence-of-obstructive-sleep-apnea-worsens-the-overall-outcome-of-intracranial-aneurysm-a-pioneer-study
#11
Shyamal C Bir, Anil Nanda, Hugo Cuellar, Hai Sun, Bharat Guthikonda, Cesar Liendo, Alireza Minagar, Oleg Y Chernyshev
OBJECTIVE Obstructive sleep apnea (OSA) is associated with the progression of abdominal and thoracic aortic aneurysms. However, the role of OSA in the overall outcome of intracranial aneurysms (IAs) has not yet been established. Authors of this report investigated the role of OSA in the overall outcome of IAs. METHODS Radiological and clinical data on patients (from 2010 through 2015) with confirmed IA were retrospectively reviewed. Significant differences between the OSA and non-OSA groups were determined using a chi-square test...
March 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28335842/central-sleep-apnea-in-heart-failure-sleeping-with-the-wrong-enemy
#12
EDITORIAL
James C Fang, Andrija Vidic
No abstract text is available yet for this article.
March 28, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28335841/cardiovascular-outcomes-with-minute%C3%A2-ventilation-targeted-adaptive-servo-ventilation-therapy-in-heart-failure-the-cat-hf-trial
#13
Christopher M O'Connor, David J Whellan, Mona Fiuzat, Naresh M Punjabi, Gudaye Tasissa, Kevin J Anstrom, Adam V Benjafield, Holger Woehrle, Amy B Blase, JoAnn Lindenfeld, Olaf Oldenberg
BACKGROUND: Sleep apnea is common in hospitalized heart failure (HF) patients and is associated with increased morbidity and mortality. OBJECTIVES: The CAT-HF (Cardiovascular Improvements With MV-ASV Therapy in Heart Failure) trial investigated whether minute ventilation (MV) adaptive servo-ventilation (ASV) improved cardiovascular outcomes in hospitalized HF patients with moderate-to-severe sleep apnea. METHODS: Eligible patients hospitalized with HF and moderate-to-severe sleep apnea were randomized to ASV plus optimized medical therapy (OMT) or OMT alone (control)...
March 28, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28324989/non-contact-real-time-estimation-of-intrapulmonary-pressure-and-tidal-volume-for-chronic-heart-failure-patients
#14
Vinh Phuc Tran, Adel Ali Al-Jumaily
Long-term continuous patient monitoring is required in many health systems for monitoring and analytical diagnosing purposes. It has been recognized that these types of monitoring systems have shortcomings related to patient comfort and/or functionality. Non-contact monitoring systems have been developed to address some of these shortcomings. One of such systems is non-contact physiological vital signs assessments for Chronic Heart Failure (CHF) patients. This paper presents a novel pulmonary ventilation model that defines the relationship between the intrapulmonary pressure and the chest displacement...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28314626/cerebral-hemodynamic-effects-of-cheyne-stokes-respiration-in-a-patient-with-stroke
#15
R C Nogueira, R B Panerai, M J Teixeira, T G Robinson, E Bor-Seng-Shu
INTRODUCTION: Cheyne-Stokes respiration (CSR) and central sleep apnea (CSA) are common in patients with heart failure and/or stroke. We aim to describe the cerebrovascular effects of CSR during the acute phase of stroke in a heart failure patient. CASE REPORT: A 74-year-old male with previous dilated cardiomyopathy had sudden onset of right hemiparesis and aphasia. A transcranial Doppler was performed with continuous measurement of blood pressure (BP) (Finometer) and end-tidal CO2 (nasal capnography)...
March 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28306346/risk-factors-for-central-serous-chorioretinopathy-multivariate-approach-in-a-case-control-study
#16
Irini Chatziralli, Stamatina A Kabanarou, Efstratios Parikakis, Alexandros Chatzirallis, Tina Xirou, Panagiotis Mitropoulos
PURPOSE: The purpose of this prospective study was to investigate the potential risk factors associated independently with central serous retinopathy (CSR) in a Greek population, using multivariate approach. MATERIALS AND METHODS: Participants in the study were 183 consecutive patients diagnosed with CSR and 183 controls, matched for age. All participants underwent complete ophthalmological examination and information regarding their sociodemographic, clinical, medical and ophthalmological history were recorded, so as to assess potential risk factors for CSR...
March 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28269228/leg-fluid-accumulation-during-prolonged-sitting
#17
Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi
The accumulation of fluid in the legs due to sedentariness can be a health risk in extreme cases. Negative health impacts associated with leg fluid accumulation include leg edema and risk of blood clots. Furthermore, fluid accumulating in the legs is accompanied by fluid shift into the upper body which is also associated with health risks such as: increased blood pressure when lying down, respiratory problems in people with heart failure, and increased sleep apnea. Understanding the pattern by which fluid accumulates in the legs can aid in the development of devices for reducing leg fluid accumulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268989/sleep-apnoea-classification-using-heart-rate-variability-ecg-derived-respiration-and-cardiopulmonary-coupling-parameters
#18
Philip de Chazal, Nadi Sadr
We investigated using heart rate variability (HRV), ECG derived respiration and cardiopulmonary coupling features (CPC) calculated from night-time single lead ECG signals to classify one-minute epochs for the presence or absence of sleep apnoea. We used the 35 training recordings of the M.I.T. Physionet Apnea-ECG database. Performance was assessed with leave-one-record-out cross-validation. The best classification performance was achieved using the CPC features in conjunction with the time-domain based HRV parameters...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268987/identifying-individual-sleep-apnea-hypoapnea-epochs-using-smartphone-based-pulse-oximetry
#19
Ainara Garde, Parastoo Dekhordi, J Mark Ansermino, Guy A Dumont
Sleep apnea, characterized by frequent pauses in breathing during sleep, poses a serious threat to the healthy growth and development of children. Polysomnography (PSG), the gold standard for sleep apnea diagnosis, is resource intensive and confined to sleep laboratories, thus reducing its accessibility. Pulse oximetry alone, providing blood oxygen saturation (SpO2) and blood volume changes in tissue (PPG), has the potential to identify children with sleep apnea. Thus, we aim to develop a tool for at-home sleep apnea screening that provides a detailed and automated 30 sec epoch-by-epoch sleep apnea analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28260880/impact-of-comorbid-conditions-in-copd-patients-on-health-care-resource-utilization-and-costs-in-a-predominantly-medicare-population
#20
Phil Schwab, Amol D Dhamane, Sari D Hopson, Chad Moretz, Srinivas Annavarapu, Kate Burslem, Andrew Renda, Shuchita Kaila
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) often have multiple underlying comorbidities, which may lead to increased health care resource utilization (HCRU) and costs. OBJECTIVE: To describe the comorbidity profiles of COPD patients and examine the associations between the presence of comorbidities and HCRU or health care costs. METHODS: A retrospective cohort study utilizing data from a large US national health plan with a predominantly Medicare population was conducted...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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