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https://www.readbyqxmd.com/read/28899537/severity-of-individual-obstruction-events-increases-with-age-in-patients-with-obstructive-sleep-apnea
#1
Timo Leppänen, Juha Töyräs, Esa Mervaala, Thomas Penzel, Antti Kulkas
BACKGROUND: Age is a risk factor of obstructive sleep apnea (OSA). It has been shown that OSA progresses over time, although conflicting results have been reported. However, the effect of age on the severity of OSA and individual obstruction events has not been investigated within different OSA severity categories by taking the most prominent confounding factors (i.e., body mass index, gender, smoking, daytime sleepiness, snoring, hypertension, heart failure, and proportion of supine sleep) into account...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28899529/qt-interval-variability-index-and-qt-interval-duration-during-different-sleep-stages-in-patients-with-obstructive-sleep-apnea
#2
Moonika Viigimae, Deniss Karai, Kristjan Pilt, Peeter Pirn, Heini Huhtala, Olli Polo, Kalju Meigas, Jyri Kaik
OBJECTIVES: The aim of the study was to investigate the impact of obstructive sleep apnea (OSA) on the QT interval variability and duration in patients during different sleep stages. METHODS: Polysomnographic recordings of 28 (13 male, 15 female) patients with OSA and 30 (15 male, 15 female) patients without OSA were analyzed. The QT interval variability index (QTVI) and the corrected QT interval (QTc) analyses were performed using two awake, 3-4 non-rapid eye movement (NREM) and three rapid eye movement (REM) sleep episodes (each 300 s)...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28888522/sleep-disordered-breathing-and-heart-failure-what-does-the-future-hold
#3
REVIEW
Martin R Cowie, Angela M Gallagher
Most patients with heart failure (HF) have sleep-disordered breathing (SDB), with central (rather than obstructive) sleep apnea becoming the predominant form in patients with more severe disease. Cyclical apnea and hypopneas are associated with sleep disturbance, hypoxemia, hemodynamic changes, and sympathetic activation. These patients have a worse prognosis than those without SDB. Mask-based therapies of positive airway pressure targeted at SDB can improve measures of sleep quality and can partially normalize the sleep and respiratory physiology...
August 30, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28885813/asleep-at-the-wheel-obstructive-sleep-apnea
#4
Richard J Fantus
Left untreated, OSA can lead to hypertension, stroke, congestive heart failure, and atrial fibrillation and s associated with type 2 diabetes and depression.... OSA strikes people of any age, including infants, and is most commonly seen in overweight or obese men older than 40 years of age.
June 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28884264/ambulatory-screening-tool-for-sleep-apnea-analyzing-a-single-lead-electrocardiogram-signal-ecg
#5
Solveig Magnusdottir, Hugi Hilmisson
STUDY OBJECTIVE: The goal was to determine the utility and accuracy of automated analysis of single-lead electrocardiogram (ECG) data using two algorithms, cardiopulmonary coupling (CPC), and cyclic variation of heart rate (CVHR) to identify sleep apnea (SA). METHODS: The CPC-CVHR algorithms were applied to identify SA by analyzing ECG from diagnostic polysomnography (PSG) from 47 subjects. The studies were rescored according to updated AASM scoring rules, both manually by a certified technologist and using an FDA-approved automated scoring software, Somnolyzer (Philips Inc...
September 7, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28882233/prognostic-significance-of-central-apneas-throughout-a-24-hour-period-in-patients%C3%A2-with-heart-failure
#6
RANDOMIZED CONTROLLED TRIAL
Michele Emdin, Gianluca Mirizzi, Alberto Giannoni, Roberta Poletti, Giovanni Iudice, Francesca Bramanti, Claudio Passino
BACKGROUND: Large trials using noninvasive mechanical ventilation to treat central apnea (CA) occurring at night ("sleep apnea") in patients with systolic heart failure (HF) have failed to improve prognosis. The prevalence and prognostic value of CA during daytime and over an entire 24-h period are not well described. OBJECTIVES: This study evaluated the occurrence and prognostic significance of nighttime, daytime, and 24-h CA episodes in a large cohort of patients with systolic HF...
September 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28862662/snorap-a-device-for-the-correction-of-impaired-sleep-health-by-using-tactile-stimulation-for-individuals-with-mild-and-moderate-sleep-disordered-breathing
#7
Mete Yağanoğlu, Murat Kayabekir, Cemal Köse
Sleep physiology and sleep hygiene play significant roles in maintaining the daily lives of individuals given that sleep is an important physiological need to protect the functions of the human brain. Sleep disordered breathing (SDB) is an important disease that disturbs this need. Snoring and Obstructive Sleep Apnea Syndrome (OSAS) are clinical conditions that affect all body organs and systems that intermittently, repeatedly, with at least 10 s or more breathing stops that decrease throughout the night and disturb sleep integrity...
September 1, 2017: Sensors
https://www.readbyqxmd.com/read/28859720/sleep-overnight-monitoring-for-apnea-in-patients-hospitalized-with-heart-failure-soma-hf-study
#8
Sunil Sharma, Paul J Mather, Anindita Chowdhury, Suchita Gupta, Umer Mukhtar, Leslee Willes, David J Whellan, Atul Malhotra, Stuart F Quan
INTRODUCTION: Sleep-disordered breathing (SDB) is highly prevalent in hospitalized patients with congestive heart failure (CHF) and the condition is diagnosed and treated in only a minority of these patients. Portable monitoring (PM) is a screening option, but due to costs and the expertise required, many hospitals may find it impractical to implement. We sought to test the utility of an alternative approach for screening hospitalized CHF patients for SDB, high-resolution pulse oximetry (HRPO)...
August 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28859717/omega-3-index-and-obstructive-sleep-apnea-a-cross-sectional-study
#9
Janine Tittus, Marie Theres Huber, Klaus Storck, Anton Köhler, Jan M Köhler, Thomas von Arnim, Clemens von Schacky
STUDY OBJECTIVES: Erythrocyte levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (Omega-3 Index) were previously found to be associated with obstructive sleep apnea (OSA) at very low levels (< 5.0%) in only one epidemiologic study. OSA has comorbidities, such as arterial hypertension, heart failure, or major depression, also associated with a low Omega-3 Index. These comorbidities can be improved by increasing intake of EPA and DHA, and thus the Omega-3 Index, preferably to its target range of 8% to 11%...
August 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28853425/obstructive-sleep-apnea-syndrome-osas-and-cardiovascular-system
#10
Carolina Lombardi, Eleonora Tobaldini, Nicola Montano, Anna Losurdo, Gianfranco Parati
There is increasing evidence of a relationship between Obstructive Sleep Apnea (OSA) and cardiovascular diseases. The strong association between OSA and arterial hypertension, in particular in patients with resistant hypertension and/or a non-dipping profile, has been extensively reported. The relationship between OSA and high blood pressure (BP) has been found independent from a number of confounders, but several factors may affect this relationship, including age and sex. It is thus important to better assess pathophysiologic and clinical interactions between OSA and arterial hypertension, also aimed at optimizing treatment approaches in OSA and hypertensive patients with co-morbidities...
August 28, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28840546/obstructive-sleep-apnea-does-not-impair-cardiorespiratory-responses-to-progressive-exercise-performed-until-exhaustion-in-hypertensive-elderly
#11
Bruno Teixeira Barbosa, Amilton da Cruz Santos, Murillo Frazão, Tulio Rocha Petrucci, Gabriel Grizzo Cucato, Adriana Oliveira Sarmento, Eduardo D S Freitas, Anna Myrna Jaguaribe de Lima, Maria do Socorro Brasileiro-Santos
BACKGROUND: Elderly people have a high prevalence to systemic arterial hypertension (SAH) and obstructive sleep apnea (OSA). Both comorbidities are closely associated and inflict damage on cardiorespiratory capacity. METHODS: In order to assess cardiorespiratory responses to the cardiopulmonary exercise test (CPET) among hypertensive elderly with OSA, we enrolled 28 subjects into two different groups: without OSA (No-OSA: apnea/hypopnea index (AHI) < 5 events/h; n = 15) and with OSA (OSA: AHI ≥ 15 events/h; n = 13)...
August 24, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28836321/association-between-left-atrial-enlargement-and-obstructive-sleep-apnea-in-a-general-population-of-71-year-old-men
#12
Henrik Holtstrand Hjälm, Michael Fu, Per-Olof Hansson, You Zhong, Kenneth Caidahl, Zacharias Mandalenakis, David Morales, Constantinos Ergatoudes, Annika Rosengren, Ludger Grote, Erik Thunström
Left atrial enlargement has been shown to be associated with obstructive sleep apnea in patients with coronary artery disease and in sleep clinic cohorts. However, data from the general population are limited. The aim of this study was to investigate whether there is an association between obstructive sleep apnea and left atrial enlargement in a random sample from a general population of 71-year-old men. As part of the longitudinal population study The Study of Men Born in 1943, we analysed cross-sectional data for 411 men, all 71 years old, who had participated in an overnight home sleep study and a standardized echocardiographic examination...
August 24, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28828627/nocturnal-blood-pressure-fluctuations-measured-by-using-pulse-transit-time-in-patients-with-severe-obstructive-sleep-apnea-syndrome
#13
Jennifer Gehring, Heiko Gesche, Gesine Drewniok, Gert Küchler, Andreas Patzak
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is related to arterial hypertension. In the present study, we test the hypothesis that patients with severe OSAS have excessive apnea induced blood pressure (BP). METHODS: We investigated 97 patients with an apnea/hypopnea index (AHI) greater than 30. Systolic BP (SBP) was continuously determined by using the pulse transit time (PTT). Apnea/hypopnea induced nocturnal BP fluctuations (NBPFs) were detected and showed phenomena of continuous increases of the SBP baseline...
August 22, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28816683/cardiorespiratory-model-based-data-driven-approach-for-sleep-apnea-detection
#14
Sandeep Gutta, Qi Cheng, Hoa Nguyen, Bruce Benjamin
Obstructive sleep apnea (OSA) is a chronic sleep disorder affecting millions of people worldwide. Individuals with OSA are rarely aware of the condition and are often left untreated, which can lead to some serious health problems. Nowadays, several low-cost wearable health sensors are available that can be used to conveniently and noninvasively collect a wide range of physiological signals. In this paper, we propose a new framework for OSA detection in which we combine the wearable sensor measurement signals with the mathematical models of the cardiorespiratory system...
August 14, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28808861/epidemiology-of-sleep-disordered-breathing-and-heart-failure-what-drives-what
#15
REVIEW
Sushma M Dharia, Lee K Brown
PURPOSE OF REVIEW: The bidirectional relationships that have been demonstrated between heart failure (HF) and central sleep apnea (CSA) demand further exploration with respect to the implications that each condition has for the other. This review discusses the body of literature that has accumulated on these relationships and how CSA and its potential treatment may affect outcomes in patients with CSA. RECENT FINDINGS: Obstructive sleep apnea (OSA) can exacerbate hypertension, type 2 diabetes, obesity, and atherosclerosis, which are known predicates of HF...
August 14, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28798255/benefits-of-oxytocin-administration-in-obstructive-sleep-apnea
#16
Vivek Jain, Joseph Marbach, Shawn Kimbro, David C Andrade, Arad Jain, Eleanor Capozzi, Kyle Mele, Rodrigo Del Rio, Matthew W Kay, David Mendelowitz
Activation of oxytocin receptors has shown benefits in animal models of Obstructive Sleep Apnea (OSA). We tested if nocturnal oxytocin administration could have beneficial effects in OSA patients. 8 patients diagnosed with OSA were administered intranasal oxytocin (40 i.u.). Changes in cardiorespiratory events during sleep, including apnea and hypopnea durations and frequency, risk of event-associated arousals, and heart rate variability were assessed. Oxytocin significantly increased indices of parasympathetic activity, including heart rate variability, total sleep time, and the Post-Polysommogram Sleep Assessment (PPSA) score, an index of self-reported sleep satisfaction...
August 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28777366/-complex-sleep-apnea-syndrome
#17
A D Palman
Complex sleep apnea syndrome (Comp-SAS) is the term used to describe a specific form of sleep disordered breathing characterized by the arise of central sleep apnea in patient with previous obstructive sleep apnea syndrome (OSAS) treated with continuous positive airway pressure devices (CPAP). The mechanisms of its occurrence are not well understood, but partly it seems to be a consequence of increased carbon dioxide elimination under positive airway pressure treatment and related improvement of pulmonary ventilation...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28762916/-predictors-of-electrical-myocardial-instability-in-men-with-arterial-hypertension-and-obstructive-sleep-apnea-hypopnea-syndrome
#18
O V Lyshova, N V Borodin, I I Kostenko
OBJECTIVE: To access the detectability of corrected QT interval (QTc) prolongation ( more or equal 450 ms) and increased QT dispersion (QTd more or equal 60 ms) in men with obstructive sleep apnea-hypopnea syndrome (OSAS) and newly diagnosed arterial hypertension (AH). MATERIAL AND METHODS: We included in this study 138 men (mean age 40.5+/-6.9 years, body mass index 34.5+/-4.7 kg/m2, all with more or equal 3 risk factors of AH development, 34% with subclinical target organs damage)...
May 2017: Kardiologiia
https://www.readbyqxmd.com/read/28760461/effect-of-dead-space-on-breathing-stability-at-exercise-in-hypoxia
#19
Eric Hermand, François J Lhuissier, Jean-Paul Richalet
Recent studies have shown that normal subjects exhibit periodic breathing when submitted to concomitant environmental (hypoxia) and physiological (exercise) stresses. A mathematical model including mass balance equations confirmed the short period of ventilatory oscillations and pointed out an important role of dead space in the genesis of these phenomena. Ten healthy subjects performed mild exercise on a cycloergometer in different conditions: rest/exercise, normoxia/hypoxia and no added dead space/added dead space (aDS)...
July 29, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28755899/the-serve-hf-safety-notice-in-clinical-practice-experiences-of-a-tertiary-sleep-center
#20
Anne-Kathrin Brill, Jacqueline Pichler Hefti, Thomas Geiser, Sebastian R Ott
BACKGROUND: In May 2015, the results of the SERVE-HF trial - addressing adaptive servoventilation (ASV) in chronic congestive heart failure (CHF) patients with central sleep apnea (CSA) - prompted a field safety notice. It was recommended to identify CHF patients treated with ASV and to advise the discontinuation of the treatment. We aimed to analyze the identification process and effect of ASV discontinuation on affected patients. METHODS: 126 patients treated with ASV on May 13th, 2015 at our institution were retrospectively analyzed...
September 2017: Sleep Medicine
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