keyword
MENU ▼
Read by QxMD icon Read
search

sleep apnea cardiovascular

keyword
https://www.readbyqxmd.com/read/28899528/back-to-sleep-or-not-the-effect-of-the-supine-position-on-pediatric-osa-sleeping-position-in-children-with-osa
#1
Lisa M Walter, Daranagama U N Dassanayake, Aidan J Weichard, Margot J Davey, Gillian M Nixon, Rosemary S C Horne
BACKGROUND: In both adults and children, obstructive sleep apnea (OSA) has significant adverse cardiovascular consequences. In adults, sleeping position has a marked effect on the severity of OSA; however, the limited number of studies conducted in children have reported conflicting findings. We aimed to evaluate the effect of sleeping position on OSA severity and the cardiovascular consequences in preschool-aged children. METHODS: This was a retrospective analysis of children (3-5 years of age) diagnosed with OSA (n = 75) and nonsnoring controls (n = 25)...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28899518/relationship-between-obstructive-sleep-apnea-and-neuroimaging-signatures-of-cerebral-small-vessel-disease-in-community-dwelling-older-adults-the-atahualpa-project
#2
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Pablo R Castillo
BACKGROUND/OBJECTIVES: Evidence of a relationship between obstructive sleep apnea (OSA) and neuroimaging signatures of cerebral small vessel disease (SVD) is limited. The present study aimed to evaluate this association in older adults living in rural Ecuador, where small vessel disease is a major pathogenetic mechanism underlying stroke. METHODS: A representative random sample of Atahualpa residents aged ≥60 years enrolled in the Atahualpa Project neuroimaging substudy underwent a single-night diagnostic polysomnography...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28893610/sex-differences-in-the-respiratory-sympathetic-coupling-in-rats-exposed-to-chronic-intermittent-hypoxia
#3
REVIEW
George Miguel P R Souza, Mateus R Amorim, Davi J A Moraes, Benedito H Machado
Obstructive sleep apnea (OSA) is a complex disease in which humans face episodes of intermittent hypoxia and it affects men and women. Patients with OSA present hypertension and sympathetic overactivity among several other dysfunctions. Therefore, one important question remains: are the autonomic dysfunctions associated with OSA similar in male and female? This is an unresolved question since sex factors are overlooked in most clinical and experimental studies. Epidemiological data indicate that sex exerts an important influence in the prevalence of OSA and associated comorbidities, such as hypertension...
September 8, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28890147/obstructive-sleep-apnea-influence-of-hypertension-on-adiponectin-inflammatory-markers-and-dyslipidemia
#4
Mahmoud R Abdel-Fadeil, Azza S Abedelhaffez, Hoda A Makhlouf, Ghada A Al Qirshi
Obstructive sleep apnea (OSA) is a common but often unrecognized condition with potentially serious complications. The aim of this study was to explore the possible mechanisms linking hypertension (HT), a common cardiovascular disease (CVD), with obstructive sleep apnea (OSA) by investigating the levels of morning and evening serum adiponectin, inflammatory markers (TNF-α, IL-6), and lipid profiles in OSA patients with and without HT. Four groups were enrolled in this case-control analytic study: control, OSA, OSA+HT, and HT groups, each of which included 22 subjects...
September 1, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28888522/sleep-disordered-breathing-and-heart-failure-what-does-the-future-hold
#5
REVIEW
Martin R Cowie, Angela M Gallagher
Most patients with heart failure (HF) have sleep-disordered breathing (SDB), with central (rather than obstructive) sleep apnea becoming the predominant form in patients with more severe disease. Cyclical apnea and hypopneas are associated with sleep disturbance, hypoxemia, hemodynamic changes, and sympathetic activation. These patients have a worse prognosis than those without SDB. Mask-based therapies of positive airway pressure targeted at SDB can improve measures of sleep quality and can partially normalize the sleep and respiratory physiology...
August 30, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28887782/development-of-acrodat-%C3%A2-a-new-software-medical-device-to-assess-disease-activity-in-patients-with-acromegaly
#6
Aart J van der Lely, Roy Gomez, Andreas Pleil, Xavier Badia, Thierry Brue, Michael Buchfelder, Pia Burman, David Clemmons, Ezio Ghigo, Jens Otto Lunde Jørgensen, Anton Luger, Joli van der Lans-Bussemaker, Susan M Webb, Christian J Strasburger
PURPOSE: Despite availability of multimodal treatment options for acromegaly, achievement of long-term disease control is suboptimal in a significant number of patients. Furthermore, disease control as defined by biochemical normalization may not always show concordance with disease-related symptoms or patient's perceived quality of life. We developed and validated a tool to measure disease activity in acromegaly to support decision-making in clinical practice. METHODS: An international expert panel (n = 10) convened to define the most critical indicators of disease activity...
September 8, 2017: Pituitary
https://www.readbyqxmd.com/read/28878905/severe-obstructive-sleep-apnea-first-screening-with-an-implanted-pacemaker
#7
Marzia Giaccardi, Giuseppe Mascia, Andrea Giomi, Lanfranco Fratoni, Barbara Binazzi, Francesco Gigliotti, Martina Nesti, Massimo Milli
Sleep apnea syndrome (SAS) is a chronic condition associated with cardiovascular disease. In some pacemakers, an advanced algorithm using transthoracic impedance may be used to identify SAS. This algorithm may be also a useful tool for a long-term monitoring helping physicians to optimize therapy, reducing risk factors, and improving therapeutic compliance.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28876375/twenty-four-hour-blood-pressure-in-obese-patients-with-moderate-to-severe-obstructive-sleep-apnea
#8
Claudia M Correa, Ronaldo A Gismondi, Ana Rosa Cunha, Mario F Neves, Wille Oigman
BACKGROUND: Obesity, systemic arterial hypertension (SAH) and obstructive sleep apnea (OSA) are closely related. Up to 70% of patients with OSA may be asymptomatic, and there is evidence that these patients have cardiovascular disease, especially nocturnal SAH. OBJECTIVES: The aim of this study was to evaluate 24-hour blood pressure circadian variation in asymptomatic, obese individuals with moderate-to-severe OSA and compare it with that in individuals with mild OSA or without OSA...
September 4, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28872361/prevalence-of-sleep-apnea-and-cardiovascular-risk-factors-in-patients-with-hypertension-in-a-day-hospital-model
#9
Eduardo Borsini, Magalí Blanco, Martín Bosio, Marcela Schrappe, Glenda Ernst, Daniela Nosetto, Nazarena Gaggioli, Alejandro Salvado, Osvaldo Manuale, Miguel Schiavone
INTRODUCTION: To identify patients at risk for obstructive sleep apnea (OSA) syndrome at a specialized hypertension center, we administered questionnaires and used respiratory polygraphy (RP). RESULTS: We studied 168 patients (64.8% men and 35.2% women). Patients' body mass index (BMI) was 34.7 ± 6.79 and Epworth Sleepiness Scale (ESS) scores were 8.01 for male and 8.92 for women (p = 0.69). RP recordings revealed AHI (Apnea-Hypopnea Index) of 18.03 ± 15...
September 5, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28871193/estradiol-regulates-txnip-and-prevents-intermittent-hypoxia-induced-vascular-injury
#10
Xiao Fei Lan, Xiu Juan Zhang, Ying Ni Lin, Qiong Wang, Hua Jun Xu, Li Na Zhou, Pei Li Chen, Qing Yun Li
Chronic intermittent hypoxia (IH) contributes to obstructive sleep apnea (OSA)-related cardiovascular diseases through increasing oxidative stress. It has been widely recognized that estradiol decreases the risk for cardiovascular disease, but the estrogen replacement therapy is limited for its side effects. Thioredoxin (Trx) and its endogenous inhibitor, thioredoxin-interacting protein (Txnip), are associated with the protective effect of estradiol in some conditions. In this study, we aimed to explore whether estradiol could protect against IH-induced vascular injury, and the possible effect of Trx-1/Txnip in this process...
September 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28865067/predictors-of-cpap-compliance-in-different-clinical-settings-primary-care-versus-sleep-unit
#11
Núria Nadal, Jordi de Batlle, Ferran Barbé, Josep Ramon Marsal, Alicia Sánchez-de-la-Torre, Nuria Tarraubella, Merce Lavega, Manuel Sánchez-de-la-Torre
BACKGROUND: Good adherence to continuous positive airway pressure (CPAP) treatment improves the patient's quality of life and decreases the risk of cardiovascular disease. Previous studies that have analyzed the adherence to CPAP were performed in a sleep unit (SU) setting. The involvement of primary care (PC) in the management of obstructive sleep apnea (OSA) patients receiving CPAP treatment could introduce factors related to the adherence to treatment. OBJECTIVES: The objective was to compare the baseline predictors of CPAP compliance in SU and PC settings...
September 1, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28863183/increased-microcirculatory-heterogeneity-in-patients-with-obstructive-sleep-apnea
#12
Lukas Ruzek, Karolina Svobodova, Lyle J Olson, Ondrej Ludka, Ivan Cundrle
INTRODUCTION: Obstructive sleep apnea (OSA) is the most common form of sleep disordered breathing and has been associated with major cardiovascular comorbidities. We hypothesized that the microcirculation is impaired in patients with OSA and that the magnitude of impairment correlates to OSA severity. METHODS: Subjects were consecutive patients scheduled for routine diagnostic polysomnography (PSG). OSA was defined by paradoxical rib cage movements together with abdominal excursions and by the apnea-hypopnea index (AHI) (events/hour; no apnea AHI<5; mild apnea 5≤AHI<15; moderate apnea 15≤AHI<30; severe apnea AHI ≥30)...
2017: PloS One
https://www.readbyqxmd.com/read/28862983/the-association-of-nov-ccn3-with-obstructive-sleep-apnea-osa-preliminary-evidence-of-a-novel-biomarker-in-osa
#13
Jeremy A Weingarten, Lars Bellner, Stephen J Peterson, Moe Zaw, Puja Chadha, Shailendra P Singh, Nader G Abraham
Obstructive sleep apnea (OSA) has a strong association with cardiovascular and metabolic abnormalities, although the mechanism driving this association is not well established. NOV/CCN3, a multifunctional extracellular matrix protein, may play a mechanistic and/or prognostic role in these associations. We hypothesized that patients with OSA, which primarily affects obese individuals, will have increased levels of NOV, and that NOV can serve as a biomarker in patients to predict OSA as well as metabolic and cardiac risk...
September 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28860787/prevalence-and-predictors-of-sleep-apnea-in-patients-with-stable-coronary-artery-disease-a-cross-sectional-study
#14
Audrius Alonderis, Giedrius Varoneckas, Nijole Raskauskiene, Julija Brozaitiene
BACKGROUND: Sleep apnea (SA) is increasingly recognized as being important in the prognosis of patients with coronary artery disease (CAD); however, symptoms of SA are not easily identified, and as many as 80% of sufferers remain undiagnosed. AIM: This cross-sectional study investigated the prevalence and predictors of SA that may help to increase the awareness and diagnosis of SA in stable CAD patients. MATERIALS AND METHODS: Polysomnography was performed in 772 medically stable CAD patients with untreated SA recruited from the Clinic of Cardiovascular Rehabilitation...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28853425/obstructive-sleep-apnea-syndrome-osas-and-cardiovascular-system
#15
Carolina Lombardi, Eleonora Tobaldini, Nicola Montano, Anna Losurdo, Gianfranco Parati
There is increasing evidence of a relationship between Obstructive Sleep Apnea (OSA) and cardiovascular diseases. The strong association between OSA and arterial hypertension, in particular in patients with resistant hypertension and/or a non-dipping profile, has been extensively reported. The relationship between OSA and high blood pressure (BP) has been found independent from a number of confounders, but several factors may affect this relationship, including age and sex. It is thus important to better assess pathophysiologic and clinical interactions between OSA and arterial hypertension, also aimed at optimizing treatment approaches in OSA and hypertensive patients with co-morbidities...
August 28, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28845957/sleep-disorders-sleep-related-breathing-disorders
#16
Deepa Burman
Sleep-related breathing disorders or sleep-disordered breathing are characterized by abnormal respiration during sleep. They are grouped into obstructive sleep apnea (OSA), central sleep apnea, sleep-related hypoventilation, and sleep-related hypoxemia disorder. OSA is a common disorder encountered in the family medicine setting that is increasingly being recognized because of the obesity epidemic and greater public and physician awareness. OSA is characterized by recurrent episodes of partial or complete closure of the upper airway resulting in disturbed breathing during sleep...
September 2017: FP Essentials
https://www.readbyqxmd.com/read/28839104/epigenetic-changes-by-dna-methylation-in-chronic-and-intermittent-hypoxia
#17
Jayasri Nanduri, Gregg L Semenza, Nanduri R Prabhakar
DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive stimulus that affects many physiological processes. The circulatory and respiratory systems adapt to chronic sustained hypoxia, such as that encountered during a high altitude sojourn. Many people living at sea level experience chronic intermittent hypoxia (IH) due to sleep apnea, which leads to cardiovascular and respiratory maladaptation...
August 24, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28829519/looking-both-ways-before-crossing-the-street-assessing-the-benefits-and-risk-of-opioids-in-treating-patients-at-risk-of-sleep-disordered-breathing-for-pain-and-dyspnea
#18
Mellar P Davis, Bertrand Behm, Diwakar Balachandran
Opioids adversely influence respiration in five distinct ways. Opioids reduce the respiratory rate, tidal volume, amplitude, reflex responses to hypercapnia and hypoxia, and arousability related necessary for respiratory adaptive responses. Opioids cause impairment of upper pharyngeal dilator muscles leading to obstructive apnea. Opioids cause complex sleep disordered breathing (SDB) consisting of central sleep apnea and obstructive sleep apnea. Clinically opioids worsen pre-existing SDB. Recent studies have shown increased morbidity and mortality in patients receiving opioids for chronic noncancer pain and chronic obstructive pulmonary disease, which appear to be related to cardiovascular events, not overdose...
May 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28828627/nocturnal-blood-pressure-fluctuations-measured-by-using-pulse-transit-time-in-patients-with-severe-obstructive-sleep-apnea-syndrome
#19
Jennifer Gehring, Heiko Gesche, Gesine Drewniok, Gert Küchler, Andreas Patzak
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is related to arterial hypertension. In the present study, we test the hypothesis that patients with severe OSAS have excessive apnea induced blood pressure (BP). METHODS: We investigated 97 patients with an apnea/hypopnea index (AHI) greater than 30. Systolic BP (SBP) was continuously determined by using the pulse transit time (PTT). Apnea/hypopnea induced nocturnal BP fluctuations (NBPFs) were detected and showed phenomena of continuous increases of the SBP baseline...
August 22, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28828052/the-role-of-obstructive-sleep-apnea-in-developing-gestational-hypertension-and-preeclampsia
#20
Laura Lungeanu-Juravle, Natalia Patrascu, Oana Claudia Deleanu, Mircea Cinteza
Gestational hypertension and preeclampsia are the most frequent medical complications in pregnancy and major causes of maternal and fetal morbidity and mortality. It is also known that these conditions are associated with a long term increased cardiovascular global risk for these young women. Obstructive sleep apnea (OSA) seems to be not only a frequent pathology associated with pregnancy but also an independent factor for developing gestational hypertension. It is well known the relationship between gestational hypertension, preeclampsia and intrauterine growth restriction of the foetus so the outcomes of this pathologies are important for both mother and child...
December 2016: Mædica
keyword
keyword
47963
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"