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https://www.readbyqxmd.com/read/28550476/stroke-and-other-cardiovascular-events-in-patients-with-obstructive-sleep-apnea-and-the-effect-of-continuous-positive-airway-pressure
#1
Mirjam H Schipper, Korne Jellema, Bregje J W Thomassen, Diego Alvarez-Estevez, Johan Verbraecken, Roselyne M Rijsman
Obstructive sleep apnea (OSA) is a known-risk factor for cardiovascular diseases. There are indications that treatment with continuous positive airway pressure (CPAP) reduces the risk of new cardiovascular events. In this study, we analyzed the incidence of cardiovascular events in patients with OSA and compared for the impact of CPAP therapy. All polysomnographies performed in 2009 and 2010 were selected with an AHI ≥5 and patients older than 18 years. These 1110 patients were approached with a questionnaire about cardiovascular events and CPAP treatment...
May 26, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28549834/obstructive-sleep-apnea-the-effect-of-bariatric-surgery-after-12%C3%A2-months-a-prospective-multicenter-trial
#2
P Peromaa-Haavisto, H Tuomilehto, J Kössi, J Virtanen, M Luostarinen, J Pihlajamäki, P Käkelä, M Victorzon
BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder, particularly in bariatric patients. It is known to be tightly linked with metabolic abnormalities and cardiovascular morbidity. Obesity is the most noteworthy individual risk factor for OSA. The aim of this study was to investigate the effect of a laparoscopic Roux-en-Y gastric bypass (LRYGB) on OSA one year after surgery. METHODS: In this prospective multicenter study standard overnight cardiorespiratory recording was conducted 12 months after bariatric surgery in 132 patients who had OSA in the baseline recording prior to the operation...
January 12, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28545542/recognition-and-treatment-of-sleep-disordered-breathing-an-important-component-of-chronic-disease-management
#3
REVIEW
Peter C Farrell, Glenn Richards
Sleep-disordered breathing (SDB) is a highly prevalent condition, and is associated with many debilitating chronic diseases. The role of untreated obstructive sleep apnea (OSA) in arterial hypertension has been recognized in international guidelines. Treatment with continuous positive airway pressure (CPAP) is associated with clinically-relevant reductions in blood pressure. In heart failure (HF), SDB is associated with worse prognosis and increased mortality. Major HF guidelines recommend that patients should be treated for sleep apnea to improve their HF status...
May 25, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28539541/sleep-disordered-breathing-in-heart-failure%C3%A3-a-therapeutic-dilemma
#4
Nobuhiko Haruki, John S Floras
Sleep-disordered breathing (SDB) occurs in approximately 50% of patients with reduced left ventricular ejection fraction receiving contemporary heart failure (HF) therapies. Obstructive (OSA) and central sleep apneas (CSA) interrupt breathing by different mechanisms but impose qualitatively similar autonomic, chemical, mechanical, and inflammatory burdens on the heart and circulation. Because contemporary evidence-based drug and device HF therapies have little or no mitigating effect on the acute or long-term consequences of such stimuli, there is a sound mechanistic rationale for targeting SDB to reduce cardiovascular event rates and prolong life...
May 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28536140/angiotensin-converting-enzyme-1-in-the-median-preoptic-nucleus-contributes-to-chronic-intermittent-hypoxia-hypertension
#5
Katelynn E Faulk, T Prashant Nedungadi, J Thomas Cunningham
Obstructive sleep apnea is associated with hypertension and cardiovascular disease. Chronic intermittent hypoxia is used to model the arterial hypoxemia seen in sleep apnea patients and is associated with increased sympathetic nerve activity and a sustained diurnal increase in blood pressure. The renin angiotensin system has been associated with hypertension seen in chronic intermittent hypoxia. Angiotensin converting enzyme 1, which cleaves angiotensin I to the active counterpart angiotensin II, is present within the central nervous system and has been shown to be regulated by AP-1 transcription factors, such as ΔFosB...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28522758/regulation-of-erythropoiesis-after-normoxic-return-from-chronic-sustained-and-intermittent-hypoxia
#6
Jihyun Song, Krishna Sundar, Radhika Gangaraju, Josef T Prchal
Hypoxia increases erythropoiesis mediated by hypoxia-inducible transcription factors (HIF) which regulate erythropoietin (EPO) transcription. Neocytolysis is a physiological mechanism that corrects polycythemia from chronic sustained hypoxemia (CSH) by transient, preferential destruction of young RBCs after normoxia is restored. We showed that neocytolysis is caused by excessive mitochondrial-derived reactive oxygen species (ROS) in reticulocytes mediated by down-regulation of HIF-controlled BNIP3L regulated mitophagy and a decrease in RBC antioxidant catalase (CAT) in hypoxia-produced erythrocytes...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28521681/effects-of-diets-on-adipose-tissue
#7
Silvia Ezquerro, Amaia Rodríguez, Piero Portincasa, Gema Frühbeck
Obesity is a major health problem that has become a global epidemic. Overweight and obesity are commonly associated with the development of several pathologies, such as insulin resistance, cardiovascular diseases, sleep apnea and several types of cancer, which can lead to further morbidity and mortality. An increased abdominal adiposity renders overweight and obese individuals more prone to metabolic and cardiovascular problems. In this sense, excess adiposity leads to several changes in the biology, morphology and function of the adipose tissue, such as adipocyte hypertrophy and hyperplasia, adipose tissue inflammation and fibrosis and an impaired secretion of adipokines, contributing to the onset of obesity-related co-morbidities...
May 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28521050/sudden-unexpected-death-during-sleep-in-familial-dysautonomia-a-case-control-study
#8
Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Miguel A Perez, Christy L Spalink, Horacio Kaufmann
Study Objectives: Sudden unexpected death during sleep (SUDS) is the most common cause of death in patients with familial dysautonomia, an autosomal recessive disease characterized by sensory and autonomic dysfunction. It remains unknown what causes SUDS in these patients and who is at highest risk. We tested the hypothesis that SUDS in FD is linked to sleep-disordered breathing. Methods: We retrospectively identified patients with familial dysautonomia who died suddenly and unexpectedly during sleep and had undergone polysomnography within the 18-month period prior to death...
May 18, 2017: Sleep
https://www.readbyqxmd.com/read/28510598/age-gender-neck-circumference-and-epworth-sleepiness-scale-do-not-predict-obstructive-sleep-apnea-osa-in-moderate-to-severe-chronic-obstructive-pulmonary-disease-copd-the-challenge-to-predict-osa-in-advanced-copd
#9
Xavier Soler, Shu-Yi Liao, Jose Maria Marin, Geraldo Lorenzi-Filho, Rachel Jen, Pamela DeYoung, Robert L Owens, Andrew L Ries, Atul Malhotra
The combination of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is associated with substantial morbidity and mortality. We hypothesized that predictors of OSA among patients with COPD may be distinct from OSA in the general population. Therefore, we investigated associations between traditional OSA risk factors (e.g. age), and sleep questionnaires [e.g. Epworth Sleepiness Scale] in 44 patients with advanced COPD. As a second aim we proposed a pilot, simplified screening test for OSA in patients with COPD...
2017: PloS One
https://www.readbyqxmd.com/read/28506075/cardiovascular-effects-of-continuous-positive-airway-pressure-treatment-in-patients-with-obstructive-sleep-apnea-a-meta-analysis
#10
Gamze Aslan, Baris Afsar, Dimitrie Siriopol, Asiye Kanbay, Oguzhan Sal, Caghan Benli, John Okcuoglu, Adrian Covic, Mehmet Kanbay
Continuous positive airway pressure (CPAP) is the first-line treatment of obstructive sleep apnea (OSA). Obstructive sleep apnea is a predictor of cardiovascular (CV) events. In this meta-analysis, we evaluated the effect of CPAP on left ventricular ejection fraction (LVEF), CV events, CV mortality, and all-cause mortality in patients with OSA. Nine articles (n = 9610 patients) were analyzed. Four different meta-analyses were performed: evaluation of LVEF, assessment of all-cause mortality, CV mortality, and CV events...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28488317/impact-of-sleep-disordered-breathing-in-patients-with-acute-myocardial-infarction-a-retrospective-analysis
#11
Verena Gessner, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg, Henrik Fox
Sleep-disordered breathing (SDB) is associated with an increased risk of cardiovascular events. Previous studies showed that severe SDB has a negative impact on myocardial salvage and progression of left ventricular dysfunction after acute myocardial infarction (AMI). This study investigated the frequency of SDB and the effects of SDB on left ventricular function after AMI. This retrospective study enrolled all patients with AMI who had undergone cardiorespiratory polygraphy for SDB diagnosis. The apnea-hypopnea index was used as a standard metric of SDB severity...
May 10, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28484896/psoriasis-is-associated-with-risk-of-obstructive-sleep-apnea-independently-from-metabolic-parameters-and-other-comorbidities-a-large-hospital-based-case-control-study
#12
Evangelia Papadavid, Maria Dalamaga, Katerina Vlami, Dimitra Koumaki, Sotirios Gyftopoulos, Gerasimos Socrates Christodoulatos, Spyridon Papiris, Dimitrios Rigopoulos
PURPOSE: Obstructive sleep apnea (OSA) represents a breathing disorder during sleep with significant health consequences. Few studies have examined the prevalence of OSA in psoriatic patients and whether OSA may be associated with psoriasis risk. We aimed to explore: (1) the inverse relationship, that is whether psoriasis might represent an independent predictor of OSA and its severity considering important predisposing factors and (2) the psoriatic phenotype related to severe OSA. METHODS: In a large hospital-based case-control study, we examined a total of 253 patients with OSA and a control group of 104 subjects without OSA, who underwent full nocturnal polysomnography and dermatologic examination...
May 8, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28474128/-chronic-hypoxia-and-cardiovascular-risk-clinical-significance-of-different-forms-of-hypoxia
#13
REVIEW
U Koehler, O Hildebrandt, J Krönig, W Grimm, J Otto, W Hildebrandt, R Kinscherf
It is of fundamental importance to differentiate whether chronic hypoxia occurs intermittently or persistently. While chronic intermittent hypoxia (CIH) is found typically in patients with obstructive sleep apnea (OAS), chronic persistent hypoxia (CPH) is typically diagnosed in patients with chronic lung disease. Cardiovascular risk is markedly increased in patients with CIH compared to patients with CPH. The frequent change between oxygen desaturation and reoxygenation in patients with CIH is associated with increased hypoxic stress, increased systemic inflammation, and enhanced adrenergic activation followed by endothelial dysfunction and increased arteriosclerosis...
May 4, 2017: Herz
https://www.readbyqxmd.com/read/28465478/chronic-obstructive-sleep-apnea-promotes-aortic-remodeling-in-canines-through-mir-145-smad3-signaling-pathway
#14
Chengyuan Yu, Yang Liu, Li Sun, Dingyu Wang, Yike Wang, Shiqi Zhao, Hui Dai, Jing Zhao, Song Zhang, Minghui Li, Yu Han, Shuang Lu, Xinwen Dong, Guangzhong Liu, Shengzhu Yu, Yue Li
Obstructive sleep apnea (OSA) is a causal pathogenetic factor of many cardiovascular diseases, however, its role in aortic diseases remains unknown. Therefore, this study was performed to explore the potential effects and pathophysiological mechanisms of chronic OSA on aortic remodeling in a canine model. After chronic OSA, the morphological changes of ascending aorta were characterized by thinner cells with pycnotic nuclei and swollen mitochondria, and obvious hyperplasia of collagenous fiber in the matrix...
April 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28458378/differences-in-dynamic-diurnal-blood-pressure-variability-between-japanese-and-american-treatment-resistant-hypertensive-populations
#15
Kazuomi Kario, Deepak L Bhatt, Sandeep Brar, George L Bakris
BACKGROUND: Dynamic diurnal changes in 24-h ambulatory systolic blood pressure (SBP) are associated with increased cardiovascular risk. We compared ambulatory BP dynamics in Japanese and American black and white populations with treatment-resistant hypertension.Methods and Results:Both HTN-Japan (n=41) and SYMPLICITY HTN-3 (n=384 white and n=140 black patients) enrolled patients with office SBP ≥160 mmHg and 24-h ambulatory SBP ≥135 mmHg while on ≥3 antihypertensive medications...
April 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28457559/periodic-limb-movements-of-sleep-are-associated-with-an-increased-prevalence-of-atrial-fibrillation-in-patients-with-mild-sleep-disordered-breathing
#16
Jiang Xie, C Anwar A Chahal, Naima Covassin, Phillip J Schulte, Prachi Singh, Narat Srivali, Virend K Somers, Sean M Caples
BACKGROUND: Growing evidence indicates that periodic limb movements of sleep (PLMS) may be related to increased risk of developing cardiovascular disease. However, the association of PLMS with atrial fibrillation (AF) is unclear, especially in patients with sleep-disordered breathing (SDB). This study sought to investigate whether PLMS were associated with increased AF prevalence, independent of established risk factors. METHODS: We performed a cross-sectional study of patients who underwent attended polysomnography at Mayo Clinic from 2011 to 2014...
April 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28455120/obstructive-sleep-apnea-is-associated-with-increased-qt-corrected-interval-dispersion-the-effects-of-continuous-positive-airway-pressure
#17
Nagihan Bilal, Nursel Dikmen, Fulsen Bozkus, Aylin Sungur, Selman Sarica, Israfil Orhan, Anil Samur
INTRODUCTION: Severe obstructive sleep apnea (OSA) is associated with increased QT corrected interval dispersion (QTcd) and continuous positive airway pressure (CPAP) is thought to improve this arrhythmogenic marker. OBJECTIVE: The aim of the study was to determine the decrease of ratio of cardiovascular risk in patients with obstructive sleep apnea. METHODS: The study included 65 patients with severe OSA who had an apnea-hypopnea index (AHI) score of >30...
March 31, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28451849/role-of-carotid-body-in-intermittent-hypoxia-related-hypertension
#18
REVIEW
Rodrigo Iturriaga, María Paz Oyarce, Ana Carolina Rodrigues Dias
Obstructive sleep apnea (OSA), a common breathing disorder, is recognized as an independent risk factor for systemic hypertension. Among the alterations induced by OSA, the chronic intermittent hypoxia (CIH) is considered the main factor for the hypertension. Exposure of rodents to CIH is the gold-standard method to study the mechanisms involved in the cardiovascular alterations induced by OSA. Although it is well known that CIH produces hypertension, the underlying mechanisms are not totally elucidated. It is likely that the CIH-induced systemic oxidative stress and inflammation may elicit endothelial dysfunction and increase the arterial blood pressure...
May 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28450367/atrial-fibrillation-epidemiology-pathophysiology-and-clinical-outcomes
#19
REVIEW
Laila Staerk, Jason A Sherer, Darae Ko, Emelia J Benjamin, Robert H Helm
The past 3 decades have been characterized by an exponential growth in knowledge and advances in the clinical treatment of atrial fibrillation (AF). It is now known that AF genesis requires a vulnerable atrial substrate and that the formation and composition of this substrate may vary depending on comorbid conditions, genetics, sex, and other factors. Population-based studies have identified numerous factors that modify the atrial substrate and increase AF susceptibility. To date, genetic studies have reported 17 independent signals for AF at 14 genomic regions...
April 28, 2017: Circulation Research
https://www.readbyqxmd.com/read/28445539/restless-legs-syndrome-and-cardiovascular-diseases-a-case-control-study
#20
Marion Cholley-Roulleau, Sofiene Chenini, Séverine Béziat, Lily Guiraud, Isabelle Jaussent, Yves Dauvilliers
OBJECTIVE: The association between restless legs syndrome (RLS), cardiovascular diseases (CVD) and hypertension is inconsistent. This case-control study examined i) the association between primary RLS, CVD and hypertension by taking into account many potential confounders and ii) the influence of RLS duration, severity and treatment, sleep and depressive symptoms on CVD and hypertension in primary RLS. METHODS: A standardized questionnaire to assess the RLS phenotype, history of CVD and hypertension, sleep and depressive symptoms, drug intake and demographic/clinical features was sent to the France-Ekbom Patients Association members...
2017: PloS One
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