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https://www.readbyqxmd.com/read/28445539/restless-legs-syndrome-and-cardiovascular-diseases-a-case-control-study
#1
Marion Cholley-Roulleau, Sofiene Chenini, Séverine Béziat, Lily Guiraud, Isabelle Jaussent, Yves Dauvilliers
OBJECTIVE: The association between restless legs syndrome (RLS), cardiovascular diseases (CVD) and hypertension is inconsistent. This case-control study examined i) the association between primary RLS, CVD and hypertension by taking into account many potential confounders and ii) the influence of RLS duration, severity and treatment, sleep and depressive symptoms on CVD and hypertension in primary RLS. METHODS: A standardized questionnaire to assess the RLS phenotype, history of CVD and hypertension, sleep and depressive symptoms, drug intake and demographic/clinical features was sent to the France-Ekbom Patients Association members...
2017: PloS One
https://www.readbyqxmd.com/read/28442310/copd-osa-overlap-syndrome-evolving-evidence-regarding-epidemiology-clinical-consequences-and-management
#2
REVIEW
Walter T McNicholas
Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSA) are both highly prevalent, which implies that both disorders occurring together (overlap syndrome) is likely to be common based on chance association alone. However, different clinical COPD phenotypes influence the likelihood of co-existing OSA in that the increased lung volumes and low body mass index (BMI) associated with the predominant emphysema phenotype protects against OSA, whereas the higher likelihood of peripheral edema and increased BMI associated with the predominant chronic bronchitis phenotype promotes OSA...
April 22, 2017: Chest
https://www.readbyqxmd.com/read/28440988/-how-safe-is-the-recombinant-human-growth-hormone
#3
Raúl Calzada-León
In this paper, several aspects related to the safety of the use of biosynthetic human growth hormone are reviewed. For example, its classification as a biosynthetic drug, the phases that need to be performed in Mexico to verify its safety (obtaining, purification, preclinical studies, clinical trials, and finally observational clinical studies), as well as the evidence that exists in relation to the association of intracranial hypertension, muscular events, scoliosis, slipped capital femoral epiphysis, obstructive sleep apnea, pancreatitis, alterations in cortisol, thyroid hormones alterations, cardiovascular disease, metabolic risk, mortality and cancer, adverse events not related to its use, and finally dosing and safety...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28437280/inhibition-of-rho-kinase-attenuates-left-ventricular-remodeling-caused-by-chronic-intermittent-hypoxia-in-rats-via-suppressing-myocardial-inflammation-and-apoptosis
#4
Zhi-Hua Wang, Die Zhu, Sheng Xie, Yan Deng, Yueying Pan, Jie Ren, Hui-Guo Liu
Chronic intermittent hypoxia (CIH), the hallmark of obstructive sleep apnea syndrome (OSAS), has been reported to play a key role in the development of OSAS-associated cardiovascular diseases including cardiac remodeling. RhoA/Rho-kinase (ROCK) pathway has also been implicated in myocardial remodeling, but the exact mechanisms are not fully elucidated. The current study's purpose is to investigate the influence of fasudil, a selective ROCK inhibitor, on CIH-induced left ventricular remodeling in rats and its possible mechanisms...
April 18, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28434626/-continuous-positive-airway-pressure-in-obstructive-sleep-apnea
#5
Jean Claude Meurice, Elise Antone, Mylene Gilbert, Audrey Watrin, Vanessa Bironneau
Continuous positive airway pressure (CPAP) is currently the most used and efficient therapy in OSAS. Efficiency of CPAP on sleep respiratory disorders is the same whether in fixed or automatic mode. Larger studies are required to evaluate their respective beneficial impact on cardiovascular or metabolic complications of OSAS. Close medical monitoring is necessary during the first weeks of CPAP therapy. Compliance to CPAP therapy is crucial for efficacy in preventing cardiovascular or metabolic complications of OSAS...
April 20, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28432297/high-probability-of-comorbidities-in-bronchial-asthma-in-germany
#6
S Heck, S Al-Shobash, D Rapp, D D Le, A Omlor, A Bekhit, M Flaig, B Al-Kadah, W Herian, R Bals, S Wagenpfeil, Q T Dinh
Clinical experience has shown that allergic and non-allergic respiratory, metabolic, mental, and cardiovascular disorders sometimes coexist with bronchial asthma. However, no study has been carried out that calculates the chance of manifestation of these disorders with bronchial asthma in Saarland and Rhineland-Palatinate, Germany. Using ICD10 diagnoses from health care institutions, the present study systematically analyzed the co-prevalence and odds ratios of comorbidities in the asthma population in Germany...
April 21, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28429850/association-of-obstructive-sleep-apnea-with-arterial-stiffness-and-nondipping-blood-pressure-in-patients-with-hypertension
#7
Raimundo Jenner, Fernanda Fatureto-Borges, Valéria Costa-Hong, Heno F Lopes, Sandra H Teixeira, Elias Marum, Dante A M Giorgi, Fernanda M Consolim-Colombo, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Eduardo M Krieger, Luciano F Drager
Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11...
April 21, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28429349/association-between-the-severity-of-newly-diagnosed-obstructive-sleep-apnea-and-subclinical-carotid-atherosclerosis-in-patients-without-overt-cardiovascular-disease
#8
K Theodoropoulos, D Lykouras, K Karkoulias, D Damania, K Leou, O Lagiou, O A Meelu, A Rigopoulou, G D Dangas, G Hahalis, K Spiropoulos, I Starakis
OBJECTIVE: Obstructive Sleep Apnea (OSA) has been associated with both subclinical and accelerated atherosclerosis; however, it still remains unknown whether this association is unique or is mediated by the higher burden of co-existing cardio-metabolic disorders frequently seen in patients with OSA. PATIENTS AND METHODS: A total of 40 subjects without clinically diagnosed cardiovascular disease (CVD) referred for polysomnography test were included in the study. Subjects with apnea/hypopnea index (AHI > 15/h) were classified as moderate/severe OSA...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28425583/sleep-apnea-syndrome-inflammation-and-oxidative-stress-in-hemodialysis-patients
#9
Olga Nikitidou, Euphemia Daskalopoulou, Aikaterini Papagianni, Vassilios Liakopoulos, Aikaterini Michalaki, Foteini Christidou, Paraskevi Argyropoulou, Dimitrios Kirmizis, Georgios Efstratiadis, Pavlos Nikolaidis, Michail Daniilidis, Nicholas Dombros
INTRODUCTION: Sleep apnea syndrome (SAS) is an established cardiovascular risk factor in the general population related to inflammation and oxidative stress and is very common among hemodialysis patients. Cardiovascular disease and its complications is the main cause of death among hemodialysis patients. The aim of the present study was to investigate the role of SAS in the promotion of inflammation and oxidative stress and thus in the augmentation of cardiovascular risk in hemodialysis patients...
April 20, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28419387/effect-of-continuous-positive-airway-pressure-treatment-on-health-related-quality-of-life-and-sleepiness-in-high-cardiovascular-risk-individuals-with-sleep-apnea-best-apnea-interventions-for-research-bestair-trial
#10
Ying Y Zhao, Rui Wang, Kevin J Gleason, Eldrin F Lewis, Stuart F Quan, Claudia M Toth, Michael Morrical, Michael Rueschman, Jia Weng, James H Ware, Murray A Mittleman, Susan Redline
Study Objectives: The long term effect of continuous positive airway pressure (CPAP) on health-related quality of life (HRQOL) in patients with high cardiovascular disease risk and obstructive sleep apnea (OSA) without severe sleepiness is uncertain. We aimed to determine the effect of CPAP treatment on HRQOL in individuals with moderate or severe OSA and cardiovascular disease (CVD) or multiple CVD risk factors without severe sleepiness. Methods: In this randomized, controlled, parallel group study, 169 participants were assigned to treatment with CPAP or the control group (conservative medical therapy [CMT] or CMT with sham CPAP)...
April 17, 2017: Sleep
https://www.readbyqxmd.com/read/28419383/cell-death-biomarkers-and-obstructive-sleep-apnea-implications-in-the-acute-coronary-syndrome
#11
Josep Miquel Bauça, Aina Yañez, Laura Fueyo, Mónica de la Peña, Javier Pierola, Alicia Sánchez-de-la-Torre, Olga Mediano, Valentín Cabriada-Nuño, María José Masdeu, Joaquin Teran-Santos, Joaquin Duran-Cantolla, Juan Fernando Masa, Jorge Abad, Manuel Sanchez-de-la-Torre, Ferran Barbé, Antònia Barceló
Background: Nucleosomes and cell-free DNA (dsDNA) have been suggested as promising biomarkers in cell death-related diseases, such as acute coronary syndrome (ACS). Currently, the impact of obstructive sleep apnea (OSA) in patients with ACS is unclear. Our aim was to evaluate the relationship between OSA, dsDNA and nucleosomes, and to assess their potential implication in the development of ACS. Methods: Up to 549 patients were included in the study and divided into 4 groups (145 ACS; 290 ACS+OSA; 62 OSA; 52 controls)...
April 17, 2017: Sleep
https://www.readbyqxmd.com/read/28408027/is-atrial-fibrillation-a-preventable-disease
#12
REVIEW
Xin Du, Jianzeng Dong, Changsheng Ma
Atrial fibrillation (AF) is an increasing burden worldwide. However, AF prevention has not been emphasized enough in clinical practice or guidelines. In this paper, the authors review the associations of modifiable lifestyle factors, including alcohol abuse, smoking, physical inactivity, and unhealthy psychological stress, with the risk for AF development. The authors also review the associations of cardiovascular risk factors that can be better managed, including obesity and overweight, high blood pressure, diabetes, dyslipidemia, obstructive sleep apnea, and other cardiovascular diseases, with the risk for AF...
April 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28402089/perioperative-management-of-obstructive-sleep-apnea-a-systematic-review
#13
Ruggero Corso, Vincenzo Russotto, Cesare Gregoretti, Davide Cattano
Obstructive sleep apnea (OSA) is the leading sleep disordered breathing condition, with a prevalence rate of moderate to severe OSA of approximately 10 - 17% in the general population. Its prevalence in the surgical population seems to be higher. However, a proportion of up to 60% of patients may not have a formal diagnosis at the moment of preoperative visit. OSA is associated with a number of comorbidities and increased perioperative risks. However, most interventions for the perioperative management of OSA patients lack high quality evidence...
April 11, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28394772/obstructive-sleep-apnea-increases-systolic-and-diastolic-blood-pressure-variability-in-hypertensive-patients
#14
Jing Shi, Jingyan Piao, Bin Liu, Yujiao Pan, Yongtai Gong, Xianzhu Deng, Weiyan Sun, Shuang Lu, Yue Li
OBJECTIVE: Obstructive sleep apnea (OSA) has been identified as the most common secondary contributing factor for the development and worsening of hypertension. However, the underlying relationships between blood pressure variability (BPV) and OSA are still not very clear. Therefore, we investigated the influences of OSA on BPV in hypertensive patients and explored the potential pathophysiologic mechanisms. PARTICIPANTS AND METHODS: Ambulatory blood pressure (BP) monitoring was carried out and polysomnography was performed to detect sleep apnea...
April 7, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28393727/platelet-indices-in-obstructive-sleep-apnea-the-role-of-mean-platelet-volume-platelet-distribution-widht-and-plateletcrit
#15
Yılmaz Bülbül, Esra Aydın Özgür, Asım Örem
Introduction: Because studies report controversial findings of mean platelet volume (MPV) and platelet distribution width (PDW), we aimed to investigate platelet indices in patients with obstructive sleep apnea (OSA). Materials and Methods: One hundred seventy three patients with OSA and 43 control subjects included in analyses. Patients with an apnea-hypopnea index (AHI) ≥ 5 were considered to have OSA and an AHI < 5 were considered as control. Platelet indices (MPV, PDW, plateletcrit) were obtained from routine analysis of blood samples using an automated blood cell counter...
September 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28392811/prevalence-of-cardiovascular-disorders-in-iranian-patients-suffering-from-obstructive-sleep-apnea
#16
Gholamreza Shirani, Seyyedeh Pouya Morovati, Ahmad Reza Shamshiri, Mehdi Nouri, Narges Ezzati Givi, Mohammad Farhadi
OBJECTIVES: Obstructive sleep apnea (OSA) can lead to various cardiovascular disorders (CVD) such as hypertension. There is no documented data about this relationship among the Iranian population. The aim of this study was to obtain comprehensive information about the severity of OSA as a cause of CVD and its relationship with other important risk factors. MATERIALS AND METHODS: In this cross sectional study, we studied patients with OSA and apnea/hypopnea index of 5 or more...
June 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28384333/relationship-between-sleep-parameters-insulin-resistance-and-age-adjusted-insulin-like-growth-factor-1-score-in-non-diabetic-older-patients
#17
Sarah Damanti, Olivier Bourron, Mohamed Doulazmi, Anne-Laure Mandengue Sosso, Vi-Huong Nguyen-Michel, Jean Mariani, Kiyoka Kinugawa
BACKGROUND: Sleep complaints are prevalent in older patients. Sleepiness, short or long sleep duration and obstructive sleep apnea (OSA) are associated with insulin resistance (IR). These parameters have not yet been considered together in the same study exploring the possible association between IR and sleep in older patients. IR is involved in cardiovascular and metabolic diseases, pathologies which are highly prevalent in older patients. Here we assess, in older non-diabetic patients with sleep complaints, the associations between IR and sleep parameters objectively recorded by polysomnography (PSG) rather than self-report...
2017: PloS One
https://www.readbyqxmd.com/read/28384127/which-is-the-ideal-marker-for-early-atherosclerosis-in-obstructive-sleep-apnea-osa-carotid-intima-media-thickness-or-mean-platelet-volume
#18
Nurhan Sarioglu, Gulen Demirpolat, Fuat Erel, Mehmet Kose
BACKGROUND Obstructive sleep apnea (OSA) is known to be closely associated with cardiovascular disease. Carotid intima-media thickness (IMT) is widely used for assessment of atherosclerosis. Mean platelet volume (MPV) is a new marker associated with atherothrombosis. In this study, we aimed to detect early atherosclerosis by measuring carotid intima-media thickness and to investigate the relationship between MPV and IMT and OSA severity. MATERIAL AND METHODS The study population consisted of 158 patients who underwent polysomnography and did not have any overt cardiac disease or risk factors...
April 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28380133/association-between-obstructive-sleep-apnea-and-myocardial-infarction-a-systematic-review
#19
Fernanda Porto, Yuri Saho Sakamoto, Cristina Salles
Obstructive sleep apnea (OSA) has been associated to cardiovascular risk factors. However, the association between OSA and cardiovascular disease is still controversial. The objective of the present study was to verify the association between OSA and myocardial infarction (MI). This is a systematic review of the literature performed through electronic data sources MEDLINE/PubMed, PubMed Central, Web of Science and BVS -Biblioteca Virtual em Saúde (Virtual Health Library). The descriptors used were: 'obstructive sleep apnea' AND 'polysomnography' AND 'myocardial infarction' AND 'adults NOT 'treatment...
March 30, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28366331/risks-associated-with-use-of-stimulant-medications-in-patients-with-obstructive-sleep-apnea-and-cardiomyopathy-a-case-control-study
#20
Meghna P Mansukhani, Bhanu Prakash Kolla, John G Park
OBJECTIVES: Stimulant medications are indicated in patients with obstructive sleep apnea (OSA) who experience sleepiness despite optimal control of sleep-disordered breathing. The safety of stimulant medications in patients with OSA and co-morbid cardiomyopathy is unknown. We performed a case-control study to assess cardiovascular outcomes and mortality risk associated with stimulant use in this group of patients. METHODS: A total of 162 subjects with OSA and cardiomyopathy were identified...
April 2017: Sleep Medicine
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