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Sellar tumors

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https://www.readbyqxmd.com/read/28719461/serotonin-atrx-and-daxx-expression-in-pituitary-adenomas-markers-in-the-differential-diagnosis-of-neuroendocrine-tumors-of-the-sellar-region
#1
Olivera Casar-Borota, Johan Botling, Dan Granberg, Jerker Stigare, Johan Wikström, Henning Bünsow Boldt, Bjarne Winther Kristensen, Fredrik Pontén, Jacqueline Trouillas
Differential diagnosis based on morphology and immunohistochemistry between a clinically nonfunctioning pituitary neuroendocrine tumor (NET)/pituitary adenoma and a primary or secondary NET of nonpituitary origin in the sellar region may be difficult. Serotonin, a frequently expressed marker in the NETs, has not been systematically evaluated in pituitary NETs. Although mutations in ATRX or DAXX have been reported in a significant proportion of pancreatic NETs, the mutational status of ATRX and DAXX and their possible pathogenetic role in pituitary NETs are unknown...
July 17, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28684370/a-primary-pigmented-choroid-plexus-papilloma-located-within-the-sella-turcica-case-report-and-literature-review
#2
Xuan Gong, Chao Liu, Longbo Zhang, Zhenyan Li, Christopher M Bartley, Zhixiong Liu
BACKGROUND: Choroid plexus papillomas (CPPs) are rare benign tumors and the pigmented subtype is even more rarely observed. CASE DESCRIPTION: We present the case of a 43-year-old woman with complaints of headache and progressive left monocular visual deterioration, whose initial plain CT showed an ovate high density tumor located within in sellar region. MRI revealed a homogeneously contrast-enhancing tumor extending from the sella turcica to the suprasellar cistern...
July 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28673886/newly-diagnosed-sellar-tumors-in-cancer-patients-a-diagnostic-challenge-and-management-dilemma
#3
Carlos R Goulart, Smita Upadhyay, Leo F S Ditzel Filho, Andre Beer-Furlan, Ricardo L Carrau, Luciano M Prevedello, Daniel M Prevedello
OBJECTIVE: The use of PET CT for staging in cancer patients and the widespread use of MRI led to an increased incidence of incidental sellar mass detection. The imaging findings can be suggestive of a benign pituitary tumor but metastasis can never be completely ruled out with non-invasive work-up. Appropriate diagnosis of these sellar masses is critical as the treatment paradigm might change in the presence of a pituitary metastasis. Moreover, definitive tissue diagnosis might prevent unnecessary radiotherapy to the skull base or even the need for systemic treatment when benign pituitary disease is confirmed...
June 30, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28668473/multiple-recurrences-require-long-term-follow-up-in-patients-diagnosed-with-spindle-cell-oncocytoma-of-the-sella-turcica
#4
Branavan Manoranjan, Alex Koziarz, Michelle M Kameda-Smith, John P Provias
Spindle cell oncocytoma (SCO) of the sella turcica is characterized as a WHO grade I non-endocrine neoplasm of the sella turcica. Histologically, these tumors contain spindled and variably oncocytic cellular processes. Although SCOs lack immunoreactivity for neuroendocrine markers and pituitary hormones, they are clinically indistinguishable from non-functioning pituitary adenomas. In contrast to the initially described benign clinical course, several reports have subsequently illustrated cases with multiple recurrences with or without histological features of anaplasia in the form of nuclear pleomorphism, frequent mitoses, high Ki-67 index, and/or necrosis...
June 28, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28667391/-tumors-of-the-sellar-region
#5
REVIEW
J M Lieb, F J Ahlhelm
METHODICAL ISSUE: The anatomy of the sellar region is complex and tumors of the sellar region are very variable because they arise from the many different tissue types in the sellar region, ranging from benign to life-threatening. Despite this variety, approximately 80% of sellar region tumors are due to the 5 most common lesions: adenomas, meningiomas, aneurysms, astrocytomas and craniopharyngiomas. STANDARD RADIOLOGICAL METHODS: In addition to clinical and laboratory results, the magnetic resonance imaging (MRI) and computed tomography (CT) results including the exact anatomical position and the proliferation pattern of the lesion are decisive for the diagnosis...
June 30, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28667039/sellar-and-suprasellar-anaplastic-hemangiopericytoma-in-a-34-year-old-man
#6
Bradley Gibson, Chiara Mancini, John Parker, Michael Applebaum, Houda Alatassi
Central nervous system hemangiopericytomas are rare, representing <1% of all primary central nervous system tumors. Hemangiopericytomas of the sellar region are exceptionally rare. Here we present a case of a sellar/suprasellar anaplastic hemangiopericytoma.The patient is a 34 year old man with a history of a resected pituitary tumor, diagnosed as a pituitary adenoma per the patient, who presented with bitemporal hemianopsia. Radiology revealed a 3.7 cm enhancing sellar/suprasellar mass with local mass effect, consistent with a pituitary adenoma...
May 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28665393/-radiotherapy-and-radiosurgery-in-treatment-of-craniopharyngiomas
#7
A N Savateev, Yu Yu Trunin, N A Mazerkina
Craniopharyngiomas are benign epithelial tumors having a dysembryogenetic origin, which are usually located in the sellar/parasellar and/or third ventricle regions. Gross total resection is the modern standard of treatment for these tumors because of a low recurrence rate. However, this surgery in some patients with craniopharyngioma often leads to the development or worsening of diencephalic disorders poorly responding to treatment. Perhaps, in these cases, subtotal or partial tumor resection or implantation of an Ommaya reservoir into the tumor cyst followed by stereotactic radiotherapy/radiosurgery may provide better functional outcomes and higher life quality in patients, with tumor growth control being reasonable (according to the published data, the mean 10-year disease-free survival is 66...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28660992/all-that-glitters-on-pet-is-not-cancer-18f-deoxy-glucose-avidity-versus-tumor-biology-pituitary-incidentaloma-in-a-survivor-of-two-previous-unrelated-malignancies
#8
Dragana Miljić, Emilija Manojlović-Gačić, Milica Skender-Gazibara, Toplica Milojević, Vojislav Bogosavljević, Nebojša Kozarević, Nebojša Petrović, Marko Stojanović, Sandra Pekić, Mirjana Doknić, Milan Petakov, Vera Popović
INTRODUCTION: 18F-deoxy-glucose positron emission tomography combined with computed tomography (18F-FDG PET/CT) is routinely used in the detection of malignant disease based on the property of malignant cells to fuel their growth and replication by increased glucose uptake. Malignant lesions are rare in the sellar region, while pituitary adenomas are the most common pathology. These are benign neoplasms with insidious onset and low proliferation activity, and therefore are only exceptionally detected by 18F-FDG PET/CT...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28644102/letter-to-the-editor-da-vinci-robot-assisted-transoral-surgery-for-sellar-tumors
#9
Hani J Marcus, David Choi, Neil L Dorward
No abstract text is available yet for this article.
June 23, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28631277/spindle-cell-oncocytoma-of-adenohypophysis-review-of-literature-and-report-of-another-recurrent-case
#10
Akash Sali, Sridhar Epari, Chandralekha Tampi, Atul Goel
Spindle cell oncocytoma (SCO) of adenohypophysis was first described in 2002 by Roncaroli et al. as a new entity in the tumors originating from adenohypophysis. It was subsequently recognized as a distinct entity in the 2007 WHO classification of CNS tumors and retained in the current updated classification. In contrast to that suggested by the original authors, this tumor does have a potential for recurrence as first described by Kloub et al. and later with many such case reports. This tumor can be confused with other sellar tumors like pituicytomas and pituitary adenoma, both radiologically and histopathologically...
June 19, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28598276/risk-factors-associated-with-postoperative-cerebrospinal-fluid-leak-after-endoscopic-endonasal-skull-base-surgery
#11
Shannon Fraser, Paul A Gardner, Maria Koutourousiou, Mark Kubik, Juan C Fernandez-Miranda, Carl H Snyderman, Eric W Wang
OBJECTIVE The aim in this paper was to determine risk factors for the development of a postoperative CSF leak after an endoscopic endonasal approach (EEA) for resection of skull base tumors. METHODS A retrospective review of patients who underwent EEA for the resection of intradural pathology between January 1997 and June 2012 was performed. Basic demographic data were collected, along with patient body mass index (BMI), tumor pathology, reconstruction technique, lumbar drainage, and outcomes. RESULTS Of the 615 patients studied, 103 developed a postoperative CSF leak (16...
June 9, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28590300/18f-fdopa-pet-imaging-in-prolactinoma
#12
Merwan Ginet, Thomas Cuny, Emmanuelle Schmitt, Pierre-Yves Marie, Antoine Verger
Pituitary macroadenoma constitutes a frequently misdiagnosed benign tumor. We report herein a case where such macroadenoma, a prolactinoma, was incidentally discovered in a 63-year-old man who had been referred to F-FDG PET and F-FDOPA PET imaging for a pharmacoresistant epilepsy. An increased uptake was documented for both radiotracers within the sellar region, although with a much higher contrast for F-FDOPA than for F-FDG. This case presents an increased uptake documented within a prolactinoma owing to the high contrast and image quality provided by F-FDOPA PET...
August 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28588668/fluid-fluid-level-on-magnetic-resonance-images-may-predict-the-occurrence-of-pituitary-adenomas-in-cystic-sellar-suprasellar-masses
#13
Deyong Xiao, Shousen Wang, Lin Zhao, Qun Zhong, Yinxing Huang, Chenyu Ding
The aim of the present study was to evaluate the value of identifying fluid-fluid level via preoperative magnetic resonance (MR) images in differentiating pituitary adenomas from craniopharyngioma, Rathke's cleft cyst (RCC), and other cystic sellar-suprasellar lesions. The data of 293 consecutive patients who underwent surgery for sellar-suprasellar lesions between July 2010 and December 2012 was retrospectively reviewed, and a total of 133 cystic cases were included in the present study. MR images and pathological features of all subjects were examined...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28560021/-coexisting-pituitary-adenoma-and-suprasellar-meningioma-a-coincidence-or-causation-effect-report-of-two-cases-and-review-of-the-literature
#14
Abbas Amirjamshidi, Seyed Abolghasem Mortazavi, Mohamad Shirani, Saeed Saeedinia, Hamed Hanif
Coexistence of pituitary adenoma (PA) and another type of brain tumor is a very rare clinical scenario. Even though such a presentation can be an incidental event but a thorough review of the literature will be made to elucidate the possible mechanisms and treatment options in similar cases. Two cases of concomitant sellar and suprasellar/diaphragmatic tumors are reported. A 37-year-old lady with prolactinoma and a suprasellar diaphragmatic meningioma and a 42-year-old acromegalic man with suprasellar/diaphragmatic meningioma and a PA...
May 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28559065/primary-pituitary-fibrosarcoma-with-prior-adenoma-a-case-report-of-a-rare-disease
#15
Ahmed Bayoumi, Jenny X Chen, Peter R Swiatek, Yosef Laviv, Ekkehard M Kasper
BACKGROUND: Pituitary sarcomas are rare clinical entities most often encountered as secondary neoplasms representing late sequelae of radiation therapy to the sellar region. Primary pituitary fibrosarcomas (PPFS) on the other hand are exceptionally rare tumors with very few cases described in the literature thus far. Herein, we present a case of PFFS and describe it in the context of the existing literature. CASE DESCRIPTION: A 39 year old female presented with two months of headaches and rapidly progressive vision loss...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28552700/analysis-of-factors-related-to-hypopituitarism-in-non-sellar-intracranial-tumor-patients
#16
Song-Song Lu, Jian-Jun Gu, Xiao-Hong Luo, Jian-He Zhang, Shou-Sen Wang
OBJECTIVES: Previous studies have suggested that postoperative hypopituitarism in patients with non-sellar intracranial tumors is caused by traumatic surgery. However, with development of minimally invasive and precise neurosurgical techniques, the degree of injury to brain tissue has been reduced significantly, especially for parenchymal tumors. Therefore, understanding pre-existing hypopituitarism and related risk factors can improve perioperative management for patients with non-sellar intracranial tumors...
May 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28532920/endoscopic-endonasal-resection-of-a-mixedlesion-of-gangliocytoma-and-non-functioning-pituitary-adenoma
#17
Li-Jun Heng, Dong Jia, Li Gong, Wei Zhang, Jie Ma, Yan Qu
BACKGROUND: The coexistence of a gangliocytoma and a pituitary adenoma is a rare event, which has only been studied in case reports previously. The knowledge of its diagnosis and treatment is extremely limited. CASE DESCRIPTION: We present a rare case of intrasellar-suprasellar gangliocytoma and non-functioning pituitary adenoma. The lesion was preoperatively diagnosed as a pituitary adenoma and resected using the extended endoscopic endonasal approach. We could clearly observe two different textures inside the tumor...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28532906/first-report-of-coexistence-of-2-ectopic-pituitary-tumors-rathke-cleft-cyst-and-silent-acth-adenoma
#18
Mirza Pojskić, Blazej Zbytek, Neal S Beckford, Frederick A Boop, Kenan I Arnautović
Rathke cleft cysts (RCCs) and pituitary adenomas (PAs) are thought to have a common embryonic ancestry. Despite this, PAs with a concomitant RCC inside the sella turcica are rarely observed; ectopic pituitary tumors are also rare. We present the case of a 65-year-old woman with an ectopic RCC in the sphenoid sinus and outside of the sella turcica concomitant with an adrenocorticotropic hormone (ACTH)-staining, clinically silent PA. The patient presented with headache but no endocrine or visual disturbances...
May 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28520927/preoperative-stratification-of-transsphenoidal-pituitary-surgery-patients-based-on-surgical-urgency
#19
Hasan A Zaidi, Amy J Wang, David J Cote, Timothy R Smith, Daniel Prevedello, Domenico Solari, Paolo Cappabianca, Monica Quiroga, Edward R Laws
BACKGROUND: Currently, there is no prioritization scale available to distinguish those patients with pituitary tumors who require urgent surgical intervention from those who are candidates for elective treatment. OBJECTIVE: To develop a classification system that can help primary care physicians, endocrinologists, neurosurgeons, ancillary support staff, and hospital administrators identify high-priority surgical candidates. METHODS: An expert international panel of clinicians consisting of endocrinologists and neurosurgeons who are involved in the diagnosis and management of sellar disease was convened...
May 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28516751/growth-hormone-therapy-and-brain-tumors
#20
Akira Teramoto
As one of the projects of the Adverse Events Study Group of the Foundation for Growth Science in Japan, the literatures on the recurrence and / or regrowth or new formation of brain tumors in patients treated with growth hormone (GH) were reviewed. Since the tumor volume of the sellar lesion can be accurately evaluated only by magnetic resonance imaging (MRI), the related literatures published after 1990 were retrieved by searching under keywords, such as GH, replacement therapy, brain tumor, recurrence, tumor formation, etc...
March 2017: Pediatric Endocrinology Reviews: PER
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