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https://www.readbyqxmd.com/read/29923940/factors-associated-with-mechanical-ventilation-use-in-children-with-sickle-cell-disease-and-acute-chest-syndrome
#1
Takuto Takahashi, Yusuke Okubo, Maria A Pereda, Atsuhiko Handa, Scott Miller
OBJECTIVES: Acute chest syndrome is the leading cause of death in children with sickle cell disease and is generally due to respiratory failure. Epidemiologic factors for a need for mechanical ventilation in children with acute chest syndrome require further clarification. DESIGN: Retrospective observational study. SETTING: Nationally representative pediatric inpatient records in the United States by using the Kids' Inpatient Database for the years 2003, 2006, 2009, and 2012...
June 19, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29920994/sleep-disordered-breathing-brain-volume-and-cognition-in-older-individuals-with-heart-failure
#2
Chooza Moon, Kelsey E Melah, Sterling C Johnson, Lisa C Bratzke
BACKGROUND AND PURPOSE: Sleep-disordered breathing is common in individuals with heart failure and may contribute to changes in the brain and decreased cognition. However, limited research has explored how the apnea-hypopnea index contributes to brain structure and cognition in this population. The aims of this study were to explore how the apnea-hypopnea index is associated with brain volume and cognition in heart failure patients. METHODS: Data of 28 heart failure patients (mean age = 67...
June 19, 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29910054/treatment-of-sleep-disordered-breathing-in-heart-failure-impacts-cardiac-remodeling-insights-from-the-cat-hf-trial
#3
Melissa A Daubert, David J Whellan, Holger Woehrle, Gudaye Tasissa, Kevin J Anstrom, JoAnn Lindenfeld, Adam Benjafield, Amy Blase, Naresh Punjabi, Mona Fiuzat, Olaf Oldenburg, Christopher M O'Connor
BACKGROUND: Sleep-disordered breathing (SDB), including central and obstructive sleep apnea, is a marker of poor prognosis in heart failure (HF) and may worsen cardiac dysfunction over time. Treatment of SDB with adaptive servoventilation (ASV) may reverse pathologic cardiac remodeling in HF patients. METHODS: The Cardiovascular Improvements with Minute Ventilation-targeted Adaptive Servo-Ventilation Therapy in Heart Failure (CAT-HF) trial randomized patients with acute decompensated HF and confirmed SDB to either optimal medical therapy (OMT) or treatment with ASV and OMT...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29897299/carotid-bodies-and-the-integrated-cardiorespiratory-response-to-hypoxia
#4
Bruce G Lindsey, Sarah C Nuding, Lauren S Segers, Kendall F Morris
Advances in our understanding of brain mechanisms for the hypoxic ventilatory response, coordinated changes in blood pressure, and the long-term consequences of chronic intermittent hypoxia as in sleep apnea, such as hypertension and heart failure, are giving impetus to the search for therapies to "erase" dysfunctional memories distributed in the carotid bodies and central nervous system. We review current network models, open questions, sex differences, and implications for translational research...
July 1, 2018: Physiology
https://www.readbyqxmd.com/read/29884256/servo-ventilation-therapy-for-sleep-disordered-breathing
#5
Virend Somers, Michael Arzt, T Douglas Bradley, Winfried Randerath, Renaud Tamisier, Christine Won
As seen in this CME online activity (available at http://journal.cme.chestnet.org/sv-sleep-disorder), central sleep apnea (CSA) is associated with increased mortality in patients with heart failure (HF), and it has been thought that treatment of CSA may improve underlying HF. Positive airway pressure therapy, specifically auto-servoventilation (ASV), can not only suppress abnormal breathing patterns but has been reported to improve cardiac function in HF patients with CSA. In patients with HF and with CSA unsuppressed with CPAP, newer ASV use has been associated with significant CSA improvement; in addition, several studies have reported efficacy of ASV in the treatment of underlying cardiac dysfunction in HF patients with CSA...
June 2018: Chest
https://www.readbyqxmd.com/read/29875929/-cardiovascular-risk-and-obstructive-sleep-apnea
#6
REVIEW
Abdelmajid Bouzerda
Obstructive sleep apnoea (OSA) affects approximately 4% of men and 2% of women in the middle ages but many of these patients are not diagnosed or treated. Cardiovascular and cerebrovascular morbidity and mortality are associated with sleep apnoea. This causal link has been confirmed in recent years on the basis of epidemiological, experimental and therapeutic data. The prevalence in the general population and the impact on the genesis and evolution of systemic and pulmonary arterial hypertension, of cardiac rhythm disorders, of coronary artery disease, of heart failure and of strokes should encourage clinicians to early diagnose and treat sleep disordered breathing and, if possible, to prevent them...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29868946/-correction-to-comorbidities-of-heart-failure-sleep-apnea
#7
H Woehrle, O Oldenburg, S Stadler, M Arzt
No abstract text is available yet for this article.
June 4, 2018: Der Internist
https://www.readbyqxmd.com/read/29860966/pro-persistent-central-sleep-apnea-hunter-cheyne-stokes-breathing-despite-best-guideline-based-therapy-of-heart-failure-with-reduced-ejection-fraction-is-a-compensatory-mechanism-and-should-not-be-suppressed
#8
Matthew T Naughton
No abstract text is available yet for this article.
May 29, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29845331/sleep-disordered-breathing-in-patients-with-cardiovascular-diseases-cannot-be-detected-by-ess-stop-bang-and-berlin-questionnaires
#9
Hannes Reuter, Simon Herkenrath, Marcel Treml, Marcel Halbach, Daniel Steven, Konrad Frank, Alessandra Castrogiovanni, Ilona Kietzmann, Stephan Baldus, Winfried J Randerath
Sleep-disordered breathing (SDB) is highly prevalent in patients with cardiovascular diseases (CVD) and associated with poor outcome. At least 50% of heart failure (HF) patients present with SDB, equally divided in obstructive sleep apnea (OSA) and central sleep apnea (CSA). CVD patients with SDB do not always present with typical SDB symptoms. Therefore, we asked whether established questionnaires allow for the reliable detection of SDB. In this prospective cohort study, 89 CVD patients (54 male, 59 ± 15 years, BMI 30 ± 6 kg/m2 ) in stable clinical state underwent an ambulatory polygraphy...
May 29, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29801743/prevalence-and-clinical-correlates-of-sleep-disordered-breathing-in-patients-hospitalized-with-acute-decompensated-heart-failure
#10
Shoko Suda, Takatoshi Kasai, Hiroki Matsumoto, Nanako Shiroshita, Mitsue Kato, Fusae Kawana, Shoichiro Yatsu, Azusa Murata, Takao Kato, Masaru Hiki, Shuo-Ju Chiang, Sakiko Miyazaki, Hiroyuki Daida
BACKGROUND: Limited data are available regarding the presence of sleep-disordered breathing (SDB) assessed using polysomnography in patients hospitalized with left ventricular (LV) systolic dysfunction after acute decompensated heart failure (ADHF). We investigated the prevalence and clinical correlates of SDB in patients hospitalized with ADHF and LV systolic dysfunction. METHODS: Prospectively collected data from 105 consecutive patients with an LV ejection fraction < 50% who were hospitalized with ADHF from May 2012 to July 2014 were retrospectively assessed...
June 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29789952/carotid-body-ablation-a-new-target-to-address-central-autonomic-dysfunction
#11
REVIEW
Rodrigo Iturriaga
PURPOSE OF REVIEW: An abnormal heightened carotid body (CB) chemoreflex, which produces autonomic dysfunction and sympathetic overactivation, is the common hallmark of obstructive sleep apnea (OSA), resistant hypertension, systolic heart failure (HF), and cardiometabolic diseases. Accordingly, it has been proposed that the elimination of the CB chemosensory input to the brainstem may reduce the autonomic and cardiorespiratory alterations in sympathetic-associated diseases in humans. RECENT FINDINGS: A growing body of evidence obtained in preclinical animal models support that an enhanced CB discharge produces sympathetic hyperactivity, baroreflex sensitivity and heart rate variability impairment, breathing instability, hypertension, and insulin resistance...
May 22, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29783029/comparison-of-stanford-b-aortic-dissection-patients-who-received-tevar-combined-with-or-without-sleep-apnea-syndrome
#12
Xin Li, Wenwu Cai, Ping Zhang, Kun Fang, Jieting Zhu, Chang Shu
BACKGROUND: Patients with Stanford B aortic dissection usually complicated with sleep apnea syndrome. This condition always threatens the patients' respiration situation. In this study, we collected and analysis data of patients' peri-operative managements of Thoracic Endovascular Aortic Repair (TEVAR) for Stanford B Aortic Dissection (AD) complicated with Sleep Apnea Syndrome (SAS). Comparison has been made between these SAS patients and those who without SAS. METHODS: Between June 2013 and June 2014, the clinical data and outcomes of the Stanford B AD patients in the department of vascular surgery in the Second Xiangya Hospital were retrospectively reviewed and studied...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29747728/management-of-obstructive-sleep-apnea-in-pregnancy
#13
REVIEW
Jennifer E Dominguez, Linda Street, Judette Louis
The spectrum of sleep-disordered breathing (SDB) ranges from mild snoring to obstructive sleep apnea, the most severe form of SDB. Current recommendations are to treat these women with continuous positive airway pressure despite limited data. SDB in early and mid-pregnancy is associated with preeclampsia and gestational diabetes. Pregnant women with a diagnosis of obstructive sleep apnea at delivery were at significantly increased risk of having cardiomyopathy, congestive heart failure, pulmonary embolism, and in-hospital death...
June 2018: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/29740701/characteristics-and-circadian-distribution-of-cardiac-arrhythmias-in-patients-with-heart-failure-and-sleep-disordered-breathing
#14
Hazem Omran, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg, Henrik Fox
BACKGROUND: Cardiac arrhythmias and sleep-disordered breathing (SDB) are common comorbidities in heart failure with reduced ejection fraction (HFrEF). However, understanding of the association between arrhythmias and SDB is poor. This study assessed the occurrence and circadian distribution of ventricular arrhythmias in HFrEF patients with and without SDB. METHODS: This retrospective analysis included HFrEF patients admitted for unattended overnight cardiorespiratory polygraphy and 24-h Holter-ECG recording...
May 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29731500/sleep-disordered-breathing-a-real-therapeutic-target-for-hypertension-pulmonary-hypertension-ischemic-heart-disease-and-chronic-heart-failure
#15
Takaaki Nakamoto
Sleep-disordered breathing (SDB) is a risk factor for cardiovascular disease including acute coronary syndrome and acute myocardial infarction, and treating SDB prevents their development and recurrence and improves a patient's prognosis. Therefore, SDB is considered a therapeutic target for cardiovascular disease. In 2010, the Japanese Circulation Society published guidelines for the diagnosis and treatment of SDB in patients with cardiovascular disease. However, therapeutic intervention for patients with SDB was recently reported not to suppress the development or deterioration of cardiovascular disease in three middle- to large-sized randomized clinical trials: the SERVE-HF trial, which examined the effects of adaptive servo-ventilation (ASV) on patients with chronic heart failure (CHF) and central sleep apnea; the CAT-HF trial, which examined the effects of ASV therapy on patients with CHF after acute deterioration; and the SAVE study, which examined the secondary preventive effect of continuous positive airway pressure (CPAP) on patients with ischemic heart disease who had mild to moderate obstructive sleep apnea...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29707357/transvenous-phrenic-nerve-stimulation-a-novel-therapeutic-approach-for-central-sleep-apnea
#16
REVIEW
Ning Ding, Xilong Zhang
Central sleep apnea (CSA) is common in heart failure (HF) patients. Traditional treatment of CSA, including continuous positive airway pressure (CPAP), adaptive servo ventilation (ASV), oxygen therapy, and CO2 inhalation, has respective limitations. Transvenous phrenic nerve stimulation (PNS), a novel therapeutic approach for CSA, was proved to be effective and safe. The remedē® system and related transvenous PNS methods was approved by FDA in 2017, for treating moderate to severe CSA.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29703065/association-of-obstructive-sleep-apnea-with-cardiovascular-outcomes-after-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis
#17
REVIEW
Xiao Wang, Jing-Yao Fan, Ying Zhang, Shao-Ping Nie, Yong-Xiang Wei
The relationship between obstructive sleep apnea (OSA) and adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI) remains unclear. We performed a systematic review and meta-analysis to assess the impact of OSA on subsequent cardiovascular events after PCI.We searched the PubMed, EMBASE, and Cochrane library from their inceptions to August 5, 2017. We included cohort studies that described the association between OSA (based on apnea-hypopnea index) and cardiovascular outcomes after PCI with stenting...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29698642/obesity-and-ventricular-repolarization-a-comprehensive-review
#18
REVIEW
Jad Omran, Brian P Bostick, Albert K Chan, Martin A Alpert
Obesity is known to be a strong predictor of sudden cardiac death. For this reason, concern exists that this association may be related to delayed ventricular repolarization (VR), which has been extensively studied in overweight and obese patients. The corrected QT interval (QTc) and QT or QTc dispersion have been the most commonly-used electrocardiographic methods for assessing VR. Multiple controlled studies demonstrated that QTc and QT or QTc dispersion were significantly longer/greater in overweight and obese subjects than in normal weight controls...
April 23, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29684317/portable-sleep-monitoring-for-diagnosing-sleep-apnea-in-hospitalized-patients-with-heart-failure
#19
R Nisha Aurora, Susheel P Patil, Naresh M Punjabi
BACKGROUND: Sleep apnea is an underdiagnosed condition in patients with heart failure. Efficient identification of sleep apnea is needed, as treatment may improve heart failure-related outcomes. Currently, use of portable sleep monitoring in hospitalized patients and those at risk for central sleep apnea is discouraged. This study examined whether portable sleep monitoring with respiratory polygraphy can accurately diagnose sleep apnea in patients hospitalized with decompensated heart failure...
April 21, 2018: Chest
https://www.readbyqxmd.com/read/29680418/uvulopalatopharyngoplasty-reduces-the-incidence-of-cardiovascular-complications-caused-by-obstructive-sleep-apnea-results-from-the-national-insurance-service-survey-2007-2014
#20
Heung Man Lee, Hyo Yeol Kim, Jeffrey D Suh, Kyung-Do Han, Jin Kook Kim, Young Chang Lim, Seok-Chan Hong, Jae Hoon Cho
OBJECTIVE: Untreated obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease including myocardial infarction (MI), congestive heart failure (CHF), and atrial fibrillation (AF). Continuous positive airway pressure (CPAP) is an effective treatment for OSA; however, compliance with CPAP can be challenging for some patients. The objective of this study was to investigate whether uvulopalatopharyngoplasty (UPPP) reduced the risk of cardiovascular complications for patients with OSA...
May 2018: Sleep Medicine
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