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https://www.readbyqxmd.com/read/28454037/agricultural-expansion-as-risk-to-endangered-wildlife-pesticide-exposure-in-wild-chimpanzees-and-baboons-displaying-facial-dysplasia
#1
Sabrina Krief, Philippe Berny, Francis Gumisiriza, Régine Gross, Barbara Demeneix, Jean Baptiste Fini, Colin A Chapman, Lauren J Chapman, Andrew Seguya, John Wasswa
Prenatal exposure to environmental endocrine disruptors can affect development and induce irreversible abnormalities in both humans and wildlife. The northern part of Kibale National Park, a mid-altitude rainforest in western Uganda, is largely surrounded by industrial tea plantations and wildlife using this area (Sebitoli) must cope with proximity to human populations and their activities. The chimpanzees and baboons in this area raid crops (primarily maize) in neighboring gardens. Sixteen young individuals of the 66 chimpanzees monitored (25%) exhibit abnormalities including reduced nostrils, cleft lip, limb deformities, reproductive problems and hypopigmentation...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28453718/cost-effectiveness-analysis-of-malaria-rapid-diagnostic-tests-for-appropriate-treatment-of-malaria-at-the-community-level-in-uganda
#2
Kristian S Hansen, Richard Ndyomugyenyi, Pascal Magnussen, Sham Lal, Siân E Clarke
In Sub-Saharan Africa, malaria remains a major cause of morbidity and mortality among children under 5, due to lack of access to prompt and appropriate diagnosis and treatment. Many countries have scaled-up community health workers (CHWs) as a strategy towards improving access. The present study was a cost-effectiveness analysis of the introduction of malaria rapid diagnostic tests (mRDTs) performed by CHWs in two areas of moderate-to-high and low malaria transmission in rural Uganda. CHWs were trained to perform mRDTs and treat children with artemisinin-based combination therapy (ACT) in the intervention arm while CHWs offered treatment based on presumptive diagnosis in the control arm...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28453513/genetic-diversity-and-population-structure-of-the-tsetse-fly-glossina-fuscipes-fuscipes-diptera-glossinidae-in-northern-uganda-implications-for-vector-control
#3
Robert Opiro, Norah P Saarman, Richard Echodu, Elizabeth A Opiyo, Kirstin Dion, Alexis Halyard, Augustine W Dunn, Serap Aksoy, Adalgisa Caccone
Uganda is the only country where the chronic and acute forms of human African Trypanosomiasis (HAT) or sleeping sickness both occur and are separated by < 100 km in areas north of Lake Kyoga. In Uganda, Glossina fuscipes fuscipes is the main vector of the Trypanosoma parasites responsible for these diseases as well for the animal African Trypanosomiasis (AAT), or Nagana. We used highly polymorphic microsatellite loci and a mitochondrial DNA (mtDNA) marker to provide fine scale spatial resolution of genetic structure of G...
April 28, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28446233/no-impact-of-strongylid-infections-on-the-detection-of-plasmodium-spp-in-faeces-of-western-lowland-gorillas-and-eastern-chimpanzees
#4
Mwanahamisi I Mapua, Barbora Pafčo, Jade Burgunder, Ilona Profousová-Pšenková, Angelique Todd, Chie Hashimoto, Moneeb A Qablan, David Modrý, Klára J Petrželková
BACKGROUND: Although a high genetic diversity of Plasmodium spp. circulating in great apes has been revealed recently due to non-invasive methods enabling detection in faecal samples, little is known about the actual mechanisms underlying the presence of Plasmodium DNA in faeces. Great apes are commonly infected by strongylid nematodes, including hookworms, which cause intestinal bleeding. The impact of strongylid infections on the detection of Plasmodium DNA in faeces was assessed in wild, western, lowland gorillas from Dzanga Sangha Protected Areas, Central African Republic and eastern chimpanzees from Kalinzu Forest Reserve, Uganda...
April 26, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28441956/what-happened-to-anti-malarial-markets-after-the-affordable-medicines-facility-malaria-pilot-trends-in-act-availability-price-and-market-share-from-five-african-countries-under-continuation-of-the-private-sector-co-payment-mechanism
#5
Sarah Tougher, Kara Hanson, Catherine Goodman
BACKGROUND: The private sector supplies anti-malarial treatment for large proportions of patients in sub-Saharan Africa. Following the large-scale piloting of the Affordable Medicines Facility-malaria (AMFm) from 2010 to 2011, a private sector co-payment mechanism (CPM) provided continuation of private sector subsidies for quality-assured artemisinin combination therapies (QAACT). This article analyses for the first time the extent to which improvements in private sector QAACT supply and distribution observed during the AMFm were maintained or intensified during continuation of the CPM through 2015 in Kenya, Madagascar, Nigeria, Tanzania and Uganda using repeat cross-sectional outlet survey data...
April 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28441458/evidence-that-promotion-of-male-circumcision-did-not-lead-to-sexual-risk-compensation-in-prioritized-sub-saharan-countries
#6
Chyun-Fung Shi, Michael Li, Jonathan Dushoff
BACKGROUND: WHO and UNAIDS prioritized 14 eastern and southern African countries with high HIV and low male circumcision prevalence for a voluntary medical male circumcision (VMMC) scale-up in 2007. Because circumcision provides only partial protection against HIV infection to men, the issue of possible risk compensation in response to VMMC campaigns is of particular concern. In this study, we looked at population-level survey data from the countries prioritized by WHO for a VMMC scale-up...
2017: PloS One
https://www.readbyqxmd.com/read/28441178/unmet-needs-persist-in-pediatric-hiv-programs-lessons-from-selected-case-studies-in-uganda
#7
Judy Orikiiriza, Jane Nakawesi, Ben Kikaire, Dorothy Turitwenka, Walter Schlech, Andrew Kambugu, Mohammed Lamorde, Johan Normark, Martina Hennessy, Victor Musiime, Joseph Rujumba, Grace Ndeezi, Nazarius M Tumwesigye, Derek G Doherty, Jane Achan
No abstract text is available yet for this article.
May 15, 2017: AIDS
https://www.readbyqxmd.com/read/28441175/acceptability-and-use-of-a-dapivirine-vaginal-ring-in-a-phase-iii-trial
#8
Elizabeth T Montgomery, Ariane van der Straten, Miria Chitukuta, Krishnaveni Reddy, Kubashni Woeber, Millicent Atujuna, Linda-Gail Bekker, Juliane Etima, Teopista Nakyanzi, Ashley J Mayo, Ariana Katz, Nicole Laborde, Cynthia I Grossman, Lydia Soto-Torres, Thesla Palanee-Phillips, Jared M Baeten
BACKGROUND: The MTN-020/ASPIRE trial evaluated the safety and effectiveness of the dapivirine vaginal ring for prevention of HIV-1 infection among African women. A nested qualitative component was conducted at six of 15 study sites in Uganda, Malawi, Zimbabwe and South Africa to evaluate acceptability of and adherence to the ring. METHOD: Qualitative study participants (n = 214) were interviewed with one of three modalities: single in-depth interview, up to three serial interviews or an exit Focus Group Discussion...
May 15, 2017: AIDS
https://www.readbyqxmd.com/read/28438118/predictors-of-delayed-culture-conversion-among-ugandan-patients
#9
Daniel Atwine, Patrick Orikiriza, Ivan Taremwa, Arnold Ayebare, Suzan Logoose, Juliet Mwanga-Amumpaire, Amina Jindani, Maryline Bonnet
BACKGROUND: Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower rates reported among African sites. The sub-study aimed at comparing TB detection rates of different culture media, within and across rifampicin-based regimens (R10, 15 and 20 mg/Kg) over a 6-month treatment follow-up period, and to establish predictors of month-2 culture non-conversion among HIV-negative TB patients enrolled at RIFATOX trial site in Uganda...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28437215/contraceptive-use-and-pregnancy-incidence-among-women-participating-in-an-hiv-prevention-trial
#10
Carolyne A Akello, Katherine E Bunge, Clemensia Nakabiito, Brenda G Mirembe, Mary Glenn Fowler, Anupam Mishra, Jeanne Marrazzo, Zvavahera M Chirenje, Connie Celum, Jennifer E Balkus
BACKGROUND: Recent HIV prevention trials required use of effective contraceptive methods to fulfill eligibility for enrollment. We compared pregnancy rates in a subset of participants enrolled in the Microbicide Trials Network protocol (MTN-003), a randomized trial of chemoprophylaxis to prevent HIV acquisition among women aged 18-45 years who initiated depot medroxyprogesterone acetate (DMPA) or combined oral contraceptives (COCs) at enrollment, relative to those already using DMPA or COCs...
February 17, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28437138/epidemiology-of-basil-downy-mildew
#11
Yigal Cohen, Yariv Ben-Naim, Lidan Falach, Evgenia Rubin
Basil downy mildew (BDM) caused by the oomycete Peronospora belbahrii is a destructive disease of sweet basil (Ocimum basilicum) worldwide. It has originated in Uganda in the 1930's and recently spread to Europe, Middle East, Americas and the Far East. Seed transmission may be responsible to its quick global spread. The pathogen attacks leaf blades, producing chlorotic lesions with ample dark asexual spores on the lower leaf surface. Oospores may occur in the mesophyll of infected leaves. The asexual spores germinate on a wet leaf surface within 2h and penetrate into the epidermis within 4h...
April 24, 2017: Phytopathology
https://www.readbyqxmd.com/read/28434689/early-childhood-transmission-of-hepatitis-b-prior-to-the-first-hepatitis-b-vaccine-dose-is-rare-among-babies-born-to-hiv-infected-and-non-hiv-infected-mothers-in-gulu-uganda
#12
E Seremba, J P Van Geertruyden, R Ssenyonga, C K Opio, J M Kaducu, J B Sempa, R Colebunders, P Ocama
BACKGROUND: Hepatitis B (HBV) in sub-Saharan Africa is believed to be horizontally acquired. However, because of the high HBV prevalence in northern Uganda, no hepatitis B vaccination at birth and no access to HBV immunoglobulin, we hypothesize that vertical transmission also could also play an important role. We therefore investigated the incidence of HBV among babies presenting for their first HBV vaccine dose in Gulu, Uganda. METHODS: We recruited mothers and their babies (at least 6-week old) presenting for their postnatal care and first HBV vaccine dose respectively...
April 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28428243/genome-wide-transcription-and-functional-analyses-reveal-heterogeneous-molecular-mechanisms-driving-pyrethroids-resistance-in-the-major-malaria-vector-anopheles-funestus-across-africa
#13
Jacob M Riveron, Sulaiman S Ibrahim, Charles Mulamba, Rousseau Djouaka, Helen Irving, Murielle J Wondji, Intan H Ishak, Charles S Wondji
Pyrethroid resistance in malaria vector, An. Funestus is increasingly reported across Africa, threatening the sustainability of pyrethroid-based control interventions including long lasting insecticidal Nets (LLINs). Managing this problem requires understanding of the molecular basis of the resistance from different regions of the continent, to establish whether it is being driven by a single or independent selective events. Here, using a genome-wide transcription profiling of pyrethroid resistant populations from Southern (Malawi), East (Uganda) and West Africa (Benin), we investigated the molecular basis of resistance, revealing strong differences between the different African regions...
April 19, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28427854/geospatial-analysis-of-unmet-pediatric-surgical-need-in-uganda
#14
Emily R Smith, Joao Ricardo Nickenig Vissoci, Thiago Augusto Hernandes Rocha, Tu M Tran, Anthony T Fuller, Elissa K Butler, Luciano de Andrade, Fredrick Makumbi, Samuel Luboga, Christine Muhumuza, Didacus B Namanya, Jeffrey G Chipman, Moses Galukande, Michael M Haglund
BACKGROUND: In low- and middle-income countries (LMICs), an estimated 85% of children do not have access to surgical care. The objective of the current study was to determine the geographic distribution of surgical conditions among children throughout Uganda. METHODS: Using the Surgeons OverSeas Assessment of Surgical Need (SOSAS) survey, we enumerated 2176 children in 2315 households throughout Uganda. At the district level, we determined the spatial autocorrelation of surgical need with geographic access to surgical centers variable...
March 31, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28427415/insecticide-resistance-patterns-in-uganda-and-the-effect-of-indoor-residual-spraying-with-bendiocarb-on-kdr-l1014s-frequencies-in-anopheles-gambiae-s-s
#15
Tarekegn A Abeku, Michelle E H Helinski, Matthew J Kirby, James Ssekitooleko, Chris Bass, Irene Kyomuhangi, Michael Okia, Godfrey Magumba, Sylvia R Meek
BACKGROUND: Resistance of malaria vectors to pyrethroid insecticides has been attributed to selection pressure from long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and the use of chemicals in agriculture. The use of different classes of insecticides in combination or by rotation has been recommended for resistance management. The aim of this study was to understand the role of IRS with a carbamate insecticide in management of pyrethroid resistance. METHODS: Anopheles mosquitoes were collected from multiple sites in nine districts of Uganda (up to five sites per district)...
April 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28424795/an-open-label-cluster-randomised-trial-to-evaluate-the-effectiveness-of-a-counselling-intervention-on-linkage-to-care-among-hiv-infected-patients-in-uganda-study-design
#16
Eugene Ruzagira, Kathy Baisley, Anatoli Kamali, Heiner Grosskurth
INTRODUCTION: Home-based HIV counselling & testing (HBHCT) is highly acceptable and has the potential to increase HIV testing uptake in sub-Saharan Africa. However, data are lacking on strategies that can effectively link HIV-positive individuals identified through HBHCT to care. This trial was designed to assess the effectiveness of two brief home-based counselling sessions on linkage to care, provided subsequent to referral for care among HIV-positive patients identified through HBHCT in a rural community in Masaka district, Uganda...
March 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28424765/community-health-volunteers-in-primary-healthcare-in-rural-uganda-factors-influencing-performance
#17
Yusufu Kuule, Andrew Eric Dobson, Desalegn Woldeyohannes, Maria Zolfo, Robinah Najjemba, Birungi Mutahunga R Edwin, Nahabwe Haven, Kristien Verdonck, Philip Owiti, Ewan Wilkinson
INTRODUCTION: Community health volunteers (CHVs) play an integral role in primary healthcare. Several countries rely on CHV programs as a major element in improving access to care and attaining universal health coverage. However, their performance has been heterogeneous and at times context-specific, and influenced by multiple factors. We describe the socio-demographic and workplace characteristics affecting CHVs' performance in a public health program in rural western Uganda. METHODS: This was a cross-sectional study based on routine program data of CHVs serving the catchment of Bwindi Community Hospital, Kanungu District, South Western Uganda, in 2014 and 2015...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28424253/identification-of-acute-hiv-1-infection-by-hologic-aptima-hiv-1-rna-qualitative-assay
#18
Mark M Manak, Leigh Anne Eller, Jennifer Malia, Linda L Jagodzinski, Rapee Trichavaroj, Joseph Oundo, Cornelia Lueer, Fatim Cham, Mark de Souza, Nelson L Michael, Merlin L Robb, Sheila A Peel
The Hologic Aptima HIV-1 Qualitative RNA assay was used in a rigorous screening approach designed to identify individuals at the earliest stage of HIV-1 infection for enrollment into subsequent studies of cellular and viral events in early infection (RV217/Early Capture HIV Cohort - ECHO Study). Volunteers at high risk of HIV-1 infection were recruited from study sites in Thailand, Tanzania, Uganda and Kenya with high HIV-1 prevalence rates among the populations examined. Small volume blood samples were collected by finger-stick at twice-weekly intervals and tested by Aptima...
April 19, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28423205/the-impact-of-biogas-and-fuelwood-use-on-institutional-kitchen-air-quality-in-kampala-uganda
#19
Aleia Ingulli McCord, Sarah Adel Stefanos, Vianney Tumwesige, Dorothy Lsoto, Anna Hillstrom Meding, Angela Adong, James Jay Schauer, Rebecca Anne Larson
Experts have suggested that microscale biogas systems offer a source of renewable energy that improves indoor air quality, but such impacts have not been directly measured. This study documented cooking behaviors and measured 2.5 μm particulate matter (PM2.5 ), carbon monoxide (CO), and sulfur dioxide (SO2 ) concentrations within 14 institutional kitchens in Kampala, Uganda that prepare meals using biogas (n=5), a mixture of biogas and fuelwood (n=3), and fuelwood (n=6). Small institutions (10-30 people) with biogas kitchens had 99% lower concentrations of PM2...
April 19, 2017: Indoor Air
https://www.readbyqxmd.com/read/28421356/the-technology-acceptance-model-for-resource-limited-settings-tam-rls-a-novel-framework-for-mobile-health-interventions-targeted-to-low-literacy-end-users-in-resource-limited-settings
#20
Jeffrey I Campbell, Isaac Aturinda, Evans Mwesigwa, Bridget Burns, Data Santorino, Jessica E Haberer, David R Bangsberg, Richard J Holden, Norma C Ware, Mark J Siedner
Although mobile health (mHealth) technologies have shown promise in improving clinical care in resource-limited settings (RLS), they are infrequently brought to scale. One limitation to the success of many mHealth interventions is inattention to end-user acceptability, which is an important predictor of technology adoption. We conducted in-depth interviews with 43 people living with HIV in rural Uganda who had participated in a clinical trial of a short messaging system (SMS)-based intervention designed to prompt return to clinic after an abnormal laboratory test...
April 18, 2017: AIDS and Behavior
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