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https://www.readbyqxmd.com/read/28224405/complications-of-acromegaly-cardiovascular-respiratory-and-metabolic-comorbidities
#1
REVIEW
Rosario Pivonello, Renata S Auriemma, Ludovica F S Grasso, Claudia Pivonello, Chiara Simeoli, Roberta Patalano, Mariano Galdiero, Annamaria Colao
Acromegaly is associated with an enhanced mortality, with cardiovascular and respiratory complications representing not only the most frequent comorbidities but also two of the main causes of deaths, whereas a minor role is played by metabolic complications, and particularly diabetes mellitus. The most prevalent cardiovascular complications of acromegaly include a cardiomyopathy, characterized by cardiac hypertrophy and diastolic and systolic dysfunction together with arterial hypertension, cardiac rhythm disorders and valve diseases, as well as vascular endothelial dysfunction...
February 21, 2017: Pituitary
https://www.readbyqxmd.com/read/28224078/complications-of-anesthesia-during-electroconvulsive-therapy-due-to-undiagnosed-obstructive-sleep-apnea-a-case-study
#2
Georgia Trakada, Lemonia Velentza, Angeliki Konsta, Athanasia Pataka, Paul Zarogoulidis, Dimitris Dikeos
This is a case description of two patients with bipolar affective disorder, who presented complications, possibly due to underlying, undiagnosed obstructive sleep apnea syndrome (OSAS), during anesthesia for electroconvulsive therapy (ECT). The first patient, just after receiving the second ECT, developed tachypnea with spasm of the upper airways and severe oxygen desaturation He was intubated and transferred to the medical intensive care unit where he was extubated 15 h later. The second patient, just after the eighth ECT, developed tachycardia and severe hypertension...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28220556/association-between-central-sleep-apnea-and-left-ventricular-structure-the-multi-ethnic-study-of-atherosclerosis
#3
Sogol Javaheri, Ravi K Sharma, David A Bluemke, Susan Redline
We assessed whether the presence of central sleep apnea is associated with adverse left ventricular structural changes. We analysed 1412 participants from the Multi-Ethnic Study of Atherosclerosis who underwent both overnight polysomnography and cardiac magnetic resonance imaging. Subjects had been recruited 10 years earlier when free of cardiovascular disease. Our main exposure is the presence of central sleep apnea as defined by central apnea-hypopnea index = 5 or the presence of Cheyne-Stokes breathing...
February 21, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28217508/obstructive-sleep-apnea-in-type-2-diabetes-and-impact-of-continuous-positive-airway-pressure-therapy-on-glycemic-control
#4
Javid Ahmad Malik, Shariq Rashid Masoodi, Sheikh Shoib
BACKGROUND: Obstructive sleep apnea (OSA) and type 2 diabetes mellitus (T2DM) are two interacting epidemics both with high prevalence and morbidity. Both epidemiologic and clinical studies suggest that the majority of patients with T2DM also have OSA and untreated OSA in these patients results in poor glycemic control leading to acceleration of diabetes-related complications. OBJECTIVES: To assess the prevalence and severity of OSA in T2DM patients and to assess the impact of OSA treatment on presenting symptoms and hemoglobin A1c (HbA1c)...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28215260/moderate-to-severe-obstructive-sleep-apnea-is-associated-with-cerebral-small-vessel-disease
#5
Tae-Jin Song, Jung-Hyun Park, Kang Hyun Choi, Yoonkyung Chang, Jangsup Moon, Ju-Hee Kim, Yunseo Choi, Yong-Jae Kim, Hyang Woon Lee
BACKGROUND: Cerebral small vessel disease (SVD) is associated with increased risk of cerebral infarction and hemorrhage. Obstructive sleep apnea (OSA) is known to increase the risk of cerebrovascular disease. This study aimed to investigate the association between cerebral SVD and severity of OSA. METHODS: A total of 170 patients were included from the patient registry at the present Sleep Center; these patients underwent both magnetic resonance imaging (MRI) of the brain and polysomnography (PSG) for suspected OSA...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215234/moderate-to-severe-obstructive-sleep-apnea-is-associated-with-subclinical-myocardial-injury-and-impaired-hemodynamics-in-pulmonary-hypertension-patients
#6
Takashi Kohno, Masaharu Kataoka, Takashi Kawakami, Ryoma Fukuoka, Yuichi Tamura, Mai Kimura, Makoto Takei, Yuichiro Maekawa, Motoaki Sano, Keiichi Fukuda
BACKGROUND: The clinical significance of obstructive sleep apnea (OSA) in pulmonary hypertension (PH) patients remains unclear. We investigated the hemodynamics and serum troponin T concentrations associated with OSA in PH patients. METHODS: Cross-sectional study was performed on data from 97 clinically stable PH patients. Using overnight sleep study, we evaluated apnea-hypopnea index (AHI) and divided patients into two groups: none-to-mild OSA (AHI < 15/h, N = 81) and moderate-to-severe OSA (AHI ≥ 15/h, N = 16)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28211992/thirty-day-outcomes-for-children-and-adolescents-undergoing-laparoscopic-sleeve-gastrectomy-at-a-free-standing-children-s-hospital
#7
A L Speer, J Parekh, F G Qureshi, E P Nadler
The obesity epidemic continues to affect millions of children and adolescents. Non-surgical options do not result in significant or sustained weight loss; thus bariatric surgery has become increasingly utilized. Limited data exist regarding safety for paediatric bariatric surgery, especially outside of National Institutes of Health (NIH)-funded centres. We hypothesized that the perioperative outcomes of paediatric patients undergoing laparoscopic sleeve gastrectomy (LSG) at our free-standing children's hospital would provide adequate safety profiles...
February 17, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28209226/sleep-apnea-types-mechanisms-and-clinical-cardiovascular-consequences
#8
REVIEW
Shahrokh Javaheri, Ferran Barbe, Francisco Campos-Rodriguez, Jerome A Dempsey, Rami Khayat, Sogol Javaheri, Atul Malhotra, Miguel A Martinez-Garcia, Reena Mehra, Allan I Pack, Vsevolod Y Polotsky, Susan Redline, Virend K Somers
Sleep apnea is highly prevalent in patients with cardiovascular disease. These disordered breathing events are associated with a profile of perturbations that include intermittent hypoxia, oxidative stress, sympathetic activation, and endothelial dysfunction, all of which are critical mediators of cardiovascular disease. Evidence supports a causal association of sleep apnea with the incidence and morbidity of hypertension, coronary heart disease, arrhythmia, heart failure, and stroke. Several discoveries in the pathogenesis, along with developments in the treatment of sleep apnea, have accumulated in recent years...
February 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28197893/gender-differences-in-clinical-and-polysomnographic-features-of-obstructive-sleep-apnea-a-clinical-study-of-2827-patients
#9
Ozen K Basoglu, Mehmet Sezai Tasbakan
PURPOSE: Obstructive sleep apnea (OSA) is underdiagnosed in females due to different clinical presentation. We aimed to determine the effect of gender on clinical and polysomnographic features and identify predictors of OSA in women. METHODS: Differences in demographic, clinical, and polysomnographic parameters between 2052 male and 775 female OSA patients were compared. RESULTS: In female OSA patients, age (56.1 ± 9.7 vs. 50.4 ± 11...
February 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28195824/sleep-surgery-in-the-elderly
#10
Christopher J Gouveia, John D Cramer, Stanley Yung-Chuan Liu, Robson Capasso
Objective Assess the frequency and nature of postoperative complications following sleep surgery. Examine these issues specifically in elderly patients to provide guidance for their perioperative care. Study Design Retrospective cohort study. Setting American College of Surgeons National Surgical Quality Improvement Program. Methods We identified patients with obstructive sleep apnea undergoing sleep surgery procedures from 2006 to 2013 in the American College of Surgeons National Surgical Quality Improvement Program, a multi-institutional outcomes program designed to improve surgical quality...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28185814/obstructive-sleep-apnea-and-pulmonary-hypertension-in-children
#11
REVIEW
David G Ingram, Alvin V Singh, Zarmina Ehsan, Brian F Birnbaum
Obstructive sleep apnea (OSA) is a common pediatric breathing disorder, affecting 1-5% of all children. Pulmonary hypertension (PH), a severe complication of OSA, is associated with significant morbidity and mortality. Despite this important relationship between OSA and PH, there is sparse literature addressing this subject in children. This review will examine the putative relationship between OSA and PH, synthesize the available literature in children, and suggest a reasonable approach, despite limited data, for clinicians...
January 11, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28181212/prevalence-and-characteristic-of-osafed-syndrome-in-atrial-fibrillation-primary-care-patients
#12
Jacek Wolf, Tadeusz Dereziński, Anna Szyndler, Krzysztof Narkiewicz
BACKGROUND: Atrial fibrillation (AF) constitutes the most prevalent arrhythmia affecting up-to 2% percent of general population. Apart from well-established risk factors which increase the odds for the development of AF e.g. age or arterial hypertension, recent analyses indicated that obstructive sleep apnea (OSA) may independently, negatively modify arrhythmia occurrence profile. Concurrently, erectile dysfunction (ED) is commonly neglected, potent marker of cardiovascular risk which considerably worsens men's psychological state...
February 9, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28181141/does-post-operative-psychotherapy-contribute-to-improved-comorbidities-in-bariatric-patients-with-borderline-personality-disorder-traits-and-bulimia-tendencies-a-prospective-study
#13
Francesca Gallé, Pietro Maida, Assunta Cirella, Elena Giuliano, Patrizia Belfiore, Giorgio Liguori
BACKGROUND: Borderline personality disorder (BPD) and eating disorders may affect the outcomes of bariatric surgery. This study was aimed to evaluate the influence of a post-operative dialectical behavioral therapy (DBT) intervention on weight loss and comorbidities in a sample of comorbid obese Italian patients with BPD traits and bulimia tendencies who underwent laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic adjustable gastric banding (LAGB). METHODS: One hundred fifty-four LRYGB or LAGB patients showing BPD and bulimia traits and type II diabetes, hypertension, and/or sleep apnea (OSAS) voluntarily adhered to DBT (n = 72) or treatment as usual (n = 82) for 12 months after surgery...
February 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28168435/is-obstructive-sleep-apnea-associated-with-the-presence-of-intracranial-cerebral-atherosclerosis
#14
Tae-Jin Song, Jung-Hyun Park, Kang Hyun Choi, Ju-Hee Kim, Yunseo Choi, Yoonkyung Chang, Hyeon Jin Kim, Jangsup Moon, Yong-Jae Kim, Hyang Woon Lee
PURPOSE: Intracranial cerebral atherosclerosis (ICAS) is one of critical atherosclerosis which closely related with stroke. Obstructive sleep apnea (OSA) is associated with systemic atherosclerosis, but it is unclear whether OSA is related with the presence of ICAS. We aimed to investigate the association between the presence of ICAS and severity of OSA in patients with suspected OSA. METHODS: This retrospective, cross-sectional study included 283 patients who suspected OSA (presence of one or more OSA-related symptom and high-risk category in Berlin questionnaire) and underwent polysomnography and brain magnetic resonance angiography (MRA)...
February 7, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28159193/screening-for-obstructive-sleep-apnea-in-the-assessment-of-coronary-risk
#15
Yan-Yi Cheung, Bee-Choo Tai, Germaine Loo, See-Meng Khoo, Karen Yin-Phoon Cheong, Ferran Barbe, Chi-Hang Lee
There is increasing awareness that health screening may prevent some acute coronary events. Yet, obstructive sleep apnea (OSA) is seldom screened for and its relation with coronary risk markers is not well established. Consecutive adults (n = 696) enrolled in a cardiovascular health screening program were approached to determine the feasibility of incorporating OSA screening. Screening included questionnaires and a home-based sleep study. High-sensitivity C-reactive protein was the primary coronary risk marker, and other laboratory- and exercise treadmill-based markers were also reported...
January 5, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28157814/hypertension-in-dialysis-patients-a-consensus-document-by-the-european-renal-and-cardiovascular-medicine-eureca-m-working-group-of-the-european-renal-association-european-dialysis-and-transplant-association-era-edta-and-the-hypertension-and-the-kidney-working
#16
Pantelis A Sarafidis, Alexandre Persu, Rajiv Agarwal, Michel Burnier, Peter de Leeuw, Charles Ferro, Jean-Michel Halimi, Gunnar Heine, Michel Jadoul, Faical Jarraya, Mehmet Kanbay, Francesca Mallamaci, Patrick B Mark, Alberto Ortiz, Gianfranco Parati, Roberto Pontremoli, Patrick Rossignol, Luis Ruilope, Patricia Van der Niepen, Raymond Vanholder, Marianne C Verharr, Andrzej Wiecek, Gregoire Wuerzner, Gérard M London, Carmine Zoccali
In patients with end-stage renal disease treated with hemodialysis or peritoneal dialysis, hypertension is very common and often poorly controlled. Blood pressure (BP) recordings obtained before or after hemodialysis display a J-shaped or U-shaped association with cardiovascular events and survival, but this most likely reflects the low accuracy of these measurements and the peculiar hemodynamic setting related with dialysis treatment. Elevated BP by home or ambulatory BP monitoring is clearly associated with shorter survival...
February 2, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28157742/stroke-epidemiology-and-risk-factor-management
#17
Amy Guzik, Cheryl Bushnell
PURPOSE OF REVIEW: Death from stroke has decreased over the past decade, with stroke now the fifth leading cause of death in the United States. In addition, the incidence of new and recurrent stroke is declining, likely because of the increased use of specific prevention medications, such as statins and antihypertensives. Despite these positive trends in incidence and mortality, many strokes remain preventable. The major modifiable risk factors are hypertension, diabetes mellitus, tobacco smoking, and hyperlipidemia, as well as lifestyle factors, such as obesity, poor diet/nutrition, and physical inactivity...
February 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28155102/stratification-of-cardiovascular-risk-in-patients-with-atrial-fibrillation-and-obstructive-sleep-apnea-validity-of-the-2mace-score
#18
Anna E Platek, Filip M Szymanski, Krzysztof J Filipiak, Alicja Dudzik-Plocica, Bartosz Krzowski, Grzegorz Karpinski
BACKGROUND: Risk stratification in patients with atrial fibrillation (AF) is critically important because this group is at high risk of mortality and morbidity. One of the comorbidities potentially affecting thromboembolic and total cardiovascular risk is obstructive sleep apnea (OSA). The aim of this study was to determine whether or not patients with atrial fibrillation and concomitant obstructive sleep apnea have a higher predicted cardiovascular risk than those without sleep-disordered breathing...
February 2, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28154583/renal-denervation-for-chronic-heart-failure-background-and-pathophysiological-rationale
#19
REVIEW
Michael Böhm, Sebastian Ewen, Felix Mahfoud
The activation of the sympathetic nervous system is associated with cardiovascular hospitalizations and death in heart failure. Renal denervation has been shown to effectively reduce sympathetic overdrive in certain patients with uncontrolled hypertension. Pilot trials investigating renal denervation as a potential treatment approach for heart failure were initiated. Heart failure comorbidities like obstructive sleep apnea, metabolic syndrome and arrhythmias could also be targets for renal denervation, because these occurrences are also mediated by the activation of the sympathetic nervous system...
January 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28150280/galectin-3-is-associated-with-coronary-plaque-burden-and-obstructive-sleep-apnea-syndrome-severity
#20
Hamdi Pusuroglu, Umut Somuncu, Ismail Bolat, Ozgur Akgul, Vesile Ornek, Hayriye Ak Yıldırım, Emre Akkaya, Huseyin Karakurt, Aydın Yıldırım, Ayfer Utku Savaş
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is reported to be associated with hypertension, coronary artery disease, atrial fibrillation, and heart failure. Galectin-3 plays an important role in the regulation of inflammation, development of cardiac fibrosis and remodeling. A significant relationship between galectin-3 and the total number of coronary plaques and the macrocalcified plaque structures of patients with type 2 DM has been reported. AIM: The aim of this study was to investigate the association between galectin-3 level and coronary plaque burden as well as OSAS severity in patients with obstructive sleep apnea syndrome...
February 2, 2017: Kardiologia Polska
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