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https://www.readbyqxmd.com/read/29667019/what-is-new-in-heart-failure-management-in-2017-update-on-acc-aha-heart-failure-guidelines
#1
REVIEW
Biykem Bozkurt
PURPOSE OF REVIEW: The goal of this paper is to provide a summary of the new recommendations in the most recent 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. The intent is to provide the background and the supporting evidence for the recommendations and to provide practical guidance for management strategies in treatment of heart failure patients...
April 17, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29662508/obstructive-sleep-apnea-is-associated-with-severity-and-long-term-prognosis-of-acute-coronary-syndrome
#2
Shuo Jia, Yu-Jie Zhou, Yi Yu, Si-Jing Wu, Yan Sun, Zhi-Jian Wang, Xiao-Li Liu, Bright Eric King, Ying-Xin Zhao, Dong-Mei Shi, Yu-Yang Liu, Zhi-Ming Zhou
Background: Obstructive sleep apnea (OSA) is a common disease in patients with acute coronary syndrome (ACS) and associated with an increased risk of fatal and nonfatal cardiovascular events. However, most patients in previous study were treated with bare metal stents and the sample sizes were relatively low. The goal of this study was to evaluate the influence of OSA on the severity and prognosis of patients admitted for ACS. Methods: In this prospective cohort study, we enrolled patients with ACS who were hospitalized for coronary angiogram/percutaneous coronary intervention and undergone polysomnography...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29660382/elevated-plasma-soluble-pro-renin-receptor-levels-are-associated-with-left-ventricular-remodeling-and-renal-function-in-chronic-heart-faiure-patients-with-reduced-ejection-fraction
#3
Linghui Gong, Shenglin Zhang, Linrui Li, Xin Gao, Dongxia Wang, Dachang Wu, Ke Wang, Yan Liu
Soluble (pro)renin receptor [s(P)RR], which is generated from cleavage of (P)RR, can be detected in plasma and urine. s(P)RR levels can reflect the severity of some diseases, such as renal lesions, gestational diabetes mellitus or hypertension, and obstructive sleep apnea syndrome. However, the relationship between s(P)RR levels and the severity of chronic heart failure remains undetermined. We studied s(P)RR levels in 118 patients with chronic heart failure with reduced ejection fraction (HFrEF), including 86 without renal dysfunction (HF) and 32 with renal dysfunction (HF + RF), and 28 healthy subjects (HS) to reveal the relationship between s(P)RR levels and other HFrEF parameters...
April 13, 2018: Peptides
https://www.readbyqxmd.com/read/29657061/risk-factors-for-new-onset-atrial-fibrillation-a-focus-on-asian-populations
#4
Yanguang Li, Daniele Pastori, Yutao Guo, Yutang Wang, Gregory Y H Lip
The incidence of new-onset atrial fibrillation (NOAF) is increasing both in the Asian populations and Western countries. Several demographic and clinical risk factors were independently associated with NOAF, including ageing, male sex, obesity, obstructive sleep apnea syndrome, hypertension, coronary artery disease, renal dysfunction and heart failure. However, some differences in the incidence of NOAF, the prevalence of some risk factors and lifestyle or environmental conditions may exist between Asian and Western countries...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29652543/cardioprotection-by-intermittent-hypoxia-conditioning-evidence-mechanisms-and-therapeutic-potential
#5
Robert T Mallet, Eugenia B Manukhina, Steven S Ruelas, James L Caffrey, H Fred Downey
The calibrated application of limited duration, cyclic, moderately intense hypoxia-reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These intermittent hypoxic conditioning (IHC) programs consistently produce striking reductions in myocardial infarction and ventricular tachyarrhythmias following coronary artery occlusion and reperfusion, and in many cases, improved contractile function and coronary blood flow. These IHC protocols are fundamentally different from those used to simulate sleep apnea, a recognized cardiovascular risk factor...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29643625/formulation-of-a-multivariate-predictive-model-for-difficult-intubation-a-double-blinded-prospective-study
#6
Anoop Kanwal Chhina, Richa Jain, Parshotam Lal Gautam, Jony Garg, Nidhi Singh, Anju Grewal
Background and Aims: Various models were devised for prediction of difficult intubation but have low positive predictive value, sensitivity and specificity. We aimed to predict difficult intubation from various airway predictive indices, in isolation and combination, and to formulate a multivariate model that can aid in accurate prediction of difficult intubation. Material and Methods: A prospective double blinded study was conducted on 500 adult patients scheduled for elective surgery under general anaesthesia...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29629282/effects-of-12-months-of-continuous-positive-airway-pressure-therapy-on-cognitive-function-sleep-mood-and-health-related-quality-of-life-in-a-peritoneal-dialysis-patient-with-obstructive-sleep-apnea
#7
Kyoung Sook Park, Jung Hyun Chang, Ea Wha Kang
This report describes the case of a hypertensive 51-year-old male with a 3-year history of peritoneal dialysis. We followed the patient through his diagnosis of severe obstructive sleep apnea (OSA) and treatment with continuous positive airway pressure (CPAP). Therapeutic use of CPAP led to the improvement of not only sleep-related problems, but also cognitive function and quality of life. To our knowledge, this is the first paper describing the benefits of long-term CPAP treatment in an OSA patient undergoing dialysis...
March 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29624144/pilot-study-of-intracranial-venous-physiology-in-craniosynostosis
#8
Martijn J Cornelissen, Robbin de Goederen, Priya Doerga, Iris Cuperus, Marie-Lise van Veelen, Maarten Lequin, Paul Govaert, Irene M J Mathijssen, Jeroen Dudink, Robert C Tasker
OBJECTIVE In addition to craniocerebral disproportion, other factors, such as Chiari malformation type I, obstructive sleep apnea, and venous outflow obstruction, are considered to have a role in the occurrence of intracranial hypertension in craniosynostosis. This pilot study examined cerebral venous flow velocity to better characterize the complex intracranial venous physiology of craniosynostosis. METHODS The authors performed a prospective cohort study of craniosynostosis patients (n = 34) referred to a single national (tertiary) craniofacial unit...
April 6, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29623221/efficacy-of-dexmedetomidine-versus-ketofol-for-sedation-of-postoperative-mechanically-ventilated-patients-with-obstructive-sleep-apnea
#9
Hatem Elmoutaz Mahmoud, Doaa Abou Elkassim Rashwan
Patients with sleep apnea are prone to postoperative respiratory complications, requiring restriction of sedatives during perioperative care. We performed a prospective randomized study on 24 patients with obstructive sleep apnea (OSA) who underwent elective surgery under general anesthesia. The patients were equally divided into two groups: Group Dex : received dexmedetomidine loading dose 1 mcg/kg IV over 10 min followed by infusion of 0.2-0.7 mcg/kg/hr; Group KFL : received ketofol as an initial bolus dose 500 mcg/kg IV (ketamine/propofol 1 : 1) and maintenance dose of 5-10 mcg/kg/min...
2018: Critical Care Research and Practice
https://www.readbyqxmd.com/read/29622460/prevalence-and-clinical-characteristics-of-obstructive-and-central-dominant-sleep-apnea-in-candidates-of-catheter-ablation-for-atrial-fibrillation-in-japan
#10
Takashi Kohno, Takehiro Kimura, Koichi Fukunaga, Wakako Yamasawa, Taishi Fujisawa, Ryoma Fukuoka, Kazuaki Nakajima, Shin Kashimura, Akira Kunitomi, Yoshinori Katsumata, Takahiko Nishiyama, Nobuhiro Nishiyama, Yoshiyasu Aizawa, Keiichi Fukuda, Seiji Takatsuki
INTRODUCTION: We aimed to study the prevalence and types of sleep apnea (SA) as well as their clinical characteristics in atrial fibrillation (AF) ablation candidates in Japan. METHODS: Before catheter ablation, 197 consecutive AF patients (age: 60 ± 9 years, body mass index; 25.0 ± 3.0) were evaluated with portable polygraphy. We compared the clinical characteristics, according to the severity of SA as well as its types, as defined by the presence of obstruction and the mixed vs...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29615922/sensory-processing-and-integration-at-the-carotid-body-tripartite-synapse-neurotransmitter-functions-and-effects-of-chronic-hypoxia
#11
REVIEW
Erin M Leonard, Shaima Salman, Colin A Nurse
Maintenance of homeostasis in the respiratory and cardiovascular systems depends on reflexes that are initiated at specialized peripheral chemoreceptors that sense changes in the chemical composition of arterial blood. In mammals, the bilaterally-paired carotid bodies (CBs) are the main peripheral chemoreceptor organs that are richly vascularized and are strategically located at the carotid bifurcation. The CBs contribute to the maintenance of O2 , CO2 /H+ , and glucose homeostasis and have attracted much clinical interest because hyperactivity in these organs is associated with several pathophysiological conditions including sleep apnea, obstructive lung disease, heart failure, hypertension, and diabetes...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29608761/correlates-and-consequences-central-sleep-apnea-in-a-national-sample-of-u-s-veterans
#12
David Ratz, Wyndy Wiitala, M S Badr, Jennifer Burns, Susmita Chowdhuri
The prevalence and consequences of central sleep apnea (CSA) in adults are not well- described. By utilizing the large Veterans Health Administration (VHA) national administrative databases, we sought to determine the incidence, clinical correlates and impact of CSA on healthcare utilization in Veterans. Analysis of a retrospective cohort of patients with sleep disorders was performed from outpatient visits and inpatient admissions from fiscal years 2006 through 2012. The CSA group, defined by International Classification of Diseases-9, was compared to a non-CSA group...
March 28, 2018: Sleep
https://www.readbyqxmd.com/read/29605723/risk-factors-for-gastrointestinal-leak-after-bariatric-surgery-mbsaqip-analysis
#13
Reza Fazl Alizadeh, Shiri Li, Colette Inaba, Patrick Penalosa, Marcelo W Hinojosa, Brian R Smith, Michael J Stamos, Ninh T Nguyen
BACKGROUND: Gastrointestinal leak remains one of the most dreaded complications in bariatric surgery. We aimed to evaluate risk factors and the impact of common perioperative interventions on the development of leak in patients underwent laparoscopic bariatric surgery. STUDY DESIGN: Using the 2015 database of accredited centers, data were analyzed for patients underwent laparoscopic sleeve gastrectomy (LSG) or Roux-en-Y gastric bypass (LRYGB). Emergent, revisional, and converted cases were excluded...
March 29, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29603807/factors-associated-with-undiagnosed-obstructive-sleep-apnea-among-hypertensive-patients-a-multisite-cross-sectional-study-in-taiwan
#14
Hsiu-Chin Hsu, Mei-Hsiang Lin, Ning-Hung Chen, Wan Jing Ho
AIMS AND OBJECTIVE: To investigate the distribution and risk factors associated with undiagnosed Obstructive Sleep Apnea (OSA) among hypertensive patients. BACKGROUND: OSA has been deemed a cardinal risk factor affecting cardiovascular event, the condition is still frequently overlooked clinically. The lack of advanced diagnosis often causes hypertensive patients with OSA to miss opportunities for preventing chronic diseases. DESIGN: A cross-sectional design...
March 31, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29589988/laparoscopic-sleeve-gastrectomy-for-morbid-obesity-at-a-veterans-affairs-medical-center
#15
Matthew Skancke, Clint Schoolfield, Robert Grossman, Jennifer C Kerns, Nicole Abel, Fredrick Brody
BACKGROUND: Class III obesity is a global health emergency associated with an increase in the incidence of many other diseases such as type 2 diabetes mellitus, hypertension, hyperlipidemia, cancer, obstructive sleep apnea, nonalcoholic fatty liver disease, osteoarthritis, infertility, and mental health disorders. Minimal work has been published regarding the efficacy of laparoscopic sleeve gastrectomy (LSG) in the veteran population to surgically manage morbid obesity. DESIGN: Retrospective analysis of LSG performed at a Veterans Affairs Medical Center (VAMC) between 2010 and 2017...
March 28, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29570509/impact-of-obstructive-sleep-apnea-on-cardiac-organ-damage-in-patients-with-acute-ischemic-stroke
#16
Paola Mattaliano, Carolina Lombardi, Davide Sangalli, Andrea Faini, Barbara Corrà, Laura Adobbati, Giovanna Branzi, Davide Mariani, Vincenzo Silani, Gianfranco Parati
BACKGROUND AND PURPOSE: Both obstructive sleep apnea (OSA) and cardiac organ damage have a crucial role in acute ischemic stroke. Our aim is to explore the relationship between OSA and cardiac organ damage in acute stroke patients. METHODS: A total of 130 consecutive patients with acute ischemic stroke were enrolled. Patients underwent full multichannel 24-h polysomnography for evaluation of OSA and echocardiography to evaluate left ventricle (LV) mass index (LV mass/BSA, LV mass/height), thickness of interventricular septum (IVS) and posterior wall (LVPW), LV ejection fraction and left atrium enlargement...
March 22, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29570476/patent-foramen-ovale-and-hypoxemia
#17
Mohammad K Mojadidi, Juan C Ruiz, Jason Chertoff, Muhammad O Zaman, Islam Y Elgendy, Ahmed N Mahmoud, Mohammad Al-Ani, Akram Y Elgendy, Nimesh K Patel, Ghanshyam Shantha, Jonathan M Tobis, Bernhard Meier
Patent foramen ovale (PFO), an embryonic remnant of the fetal circulation, is present in 20-25% of adults. While recent observational studies and clinical trials have established the link between PFO-mediated right-to-left shunting with cryptogenic stroke and migraine with aura, the role of a PFO in exacerbating hypoxemic medical conditions (i.e., sleep apnea, chronic obstructive pulmonary disease, pulmonary hypertension, platypnea-orthodeoxia, pulmonary arteriovenous malformation, high altitude pulmonary edema, and exercise desaturation) remains poorly evaluated...
March 22, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29567059/conversion-of-standard-roux-en-y-gastric-bypass-to-distal-bypass-for-weight-loss-failure-and-metabolic-syndrome-3-year-follow-up-and-evolution-of-technique-to-reduce-nutritional-complications
#18
Saber Ghiassi, Kelvin Higa, Steven Chang, Pearl Ma, Aaron Lloyd, Keith Boone, Eric J DeMaria
BACKGROUND: Standard proximal Roux-en-Y gastric bypass (RYGB) fails to achieve long-term weight maintenance and/or control of metabolic syndrome in up to 35% of patients. OBJECTIVES: To improve the performance of the standard proximal gastric bypass by increasing the biliopancreatic limb length at the expense of the common channel. SETTINGS: Academic-affiliated private practice. METHODS: A retrospective review of all patients who underwent conversion to distal RYGB from 2010 to 2016 was performed...
January 31, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29562536/update-on-vascular-cognitive-impairment-associated-with-subcortical-small-vessel-disease
#19
Anders Wallin, Gustavo C Román, Margaret Esiri, Petronella Kettunen, Johan Svensson, George P Paraskevas, Elisabeth Kapaki
Subcortical small-vessel disease (SSVD) is a disorder well characterized from the clinical, imaging, and neuropathological viewpoints. SSVD is considered the most prevalent ischemic brain disorder, increasing in frequency with age. Vascular risk factors include hypertension, diabetes, hyperlipidemia, elevated homocysteine, and obstructive sleep apnea. Ischemic white matter lesions are the hallmark of SSVD; other pathological lesions include arteriolosclerosis, dilatation of perivascular spaces, venous collagenosis, cerebral amyloid angiopathy, microbleeds, microinfarcts, lacunes, and large infarcts...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29556729/role-of-mineralocorticoid-receptors-in-obstructive-sleep-apnea-and-metabolic-syndrome
#20
REVIEW
Badhma Valaiyapathi, David A Calhoun
PURPOSE OF REVIEW: This review will summarize recent developments in the research on the mineralocorticoid receptor and its impact on obstructive sleep apnea and metabolic syndrome. RECENT FINDINGS: Aldosterone excess plays an important role in the association between resistant hypertension and obstructive sleep apnea. The prevalence of obesity is increasing rapidly worldwide and is especially common among patients with obstructive sleep apnea, resistant hypertension, and metabolic syndrome, suggesting probable mechanistic links between these three conditions...
March 19, 2018: Current Hypertension Reports
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