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https://www.readbyqxmd.com/read/29450504/association-of-adenotonsillectomy-with-blood-pressure-among-hypertensive-and-nonhypertensive-children-with-obstructive-sleep-apnea
#1
Cho-Hsueh Lee, Kun-Tai Kang, Shuenn-Nan Chiu, I-Sheng Chang, Wen-Chin Weng, Pei-Lin Lee, Wei-Chung Hsu
Importance: Hypertension in childhood may continue into adulthood and lead to adverse cardiovascular outcomes. Evidence suggests that adenotonsillectomy for childhood obstructive sleep apnea (OSA) may be associated with blood pressure (BP) improvement. However, how adenotonsillectomy is associated with BP in hypertensive and nonhypertensive children with OSA remains unclear. Objective: To investigate disparities in BP changes after adenotonsillectomy in hypertensive and nonhypertensive children with OSA...
February 15, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29446755/classification-methods-to-detect-sleep-apnea-in-adults-based-on-respiratory-and-oximetry-signals-a-systematic-review
#2
Md Bashir Uddin, Chin-Moi Chow, Steven W Su
Sleep apnea (SA), a common sleep disorder, can significantly decrease the quality of life, and is closely associated with major health risk such as cardiovascular disease, sudden death, depression, and hypertension. Normal diagnostic process of SA using polysomnography (PSG) is costly and time consuming. In addition, the accuracy of different classification methods to detect SA varies with the use of different physiological signals. If an effective, reliable, and accurate classification method is developed, then the diagnosis of SA and their associated treatment will be time-efficient and economical...
February 15, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29442289/correction-to-obstructive-sleep-apnea-does-not-impair-cardiorespiratory-responses-to-progressive-exercise-performed-until-exhaustion-in-hypertensive-elderly
#3
Bruno Teixeira Barbosa, Amilton da Cruz Santos, Murillo Frazão, Tulio Rocha Petrucci, Gabriel Grizzo Cucato, Adriana Oliveira Sarmento, Eduardo D S Freitas, Anna Myrna Jaguaribe de Lima, Maria do Socorro Brasileiro-Santos
The original version of this article was published online containing two items that require correction, namely the abstract (Results section) and Table 3.
February 13, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29435811/comparative-outcomes-of-bariatric-surgery-in-patients-with-impaired-mobility-and-ambulatory-population
#4
Gautam Sharma, Zubaidah Nor-Hanipah, Ivy N Haskins, Suriya Punchai, Andrew T Strong, Chao Tu, John H Rodriguez, Phillip R Schauer, Matthew Kroh
PURPOSE: This study aims to characterize complications, metabolic improvement, and change in ambulation status for patients with impaired mobility undergoing bariatric surgery. MATERIAL AND METHODS: Individuals undergoing primary sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) from February 2008 to December 2015 were included. Impaired mobility (WC) was defined as using a wheelchair or motorized scooter for at least part of a typical day. The WC group was propensity score matched to ambulatory patients (1:5 ratio)...
February 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29432207/prevalence-of-comorbid-conditions-pre-existing-and-diagnosed-at-a-tertiary-care-pediatric-weight-management-clinic
#5
Griselle Leon, Elizabeth de Klerk, Josephine Ho, Michelle Jackman, Raylene A Reimer, Kimberly E Connors, Paola Luca
BACKGROUND: Childhood obesity places individuals at risk for a multitude of physical and mental health problems. The aim of this study was to assess the prevalence of obesity related comorbidities diagnosed prior to and after attending a tertiary care pediatric weight management clinic. METHODS: A cross sectional retrospective chart review of patients 2-17 years old seen in the weight management clinic at Alberta Children's Hospital from May 2012 to May 2014. RESULTS: A total of 199 patients were included in the review...
February 13, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29429026/modulation-of-renal-sympathetic-innervation-recent-insights-beyond-blood-pressure-control
#6
REVIEW
Dominik Linz, Mathias Hohl, Adrian D Elliott, Dennis H Lau, Felix Mahfoud, Murray D Esler, Prashanthan Sanders, Michael Böhm
Renal afferent and efferent sympathetic nerves are involved in the regulation of blood pressure and have a pathophysiological role in hypertension. Additionally, several conditions that frequently coexist with hypertension, such as heart failure, obstructive sleep apnea, atrial fibrillation, renal dysfunction, and metabolic syndrome, demonstrate enhanced sympathetic activity. Renal denervation (RDN) is an approach to reduce renal and whole body sympathetic activation. Experimental models indicate that RDN has the potential to lower blood pressure and prevent cardio-renal remodeling in chronic diseases associated with enhanced sympathetic activation...
February 10, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29425754/does-the-medical-comorbidity-profile-of-obstructive-sleep-apnea-patients-treated-with-maxillomandibular-advancement-differ-from-that-of-obstructive-sleep-apnea-patients-managed-nonsurgically
#7
Richard Ngo, Elaina Pullano, Zachary S Peacock, Edward T Lahey, Meredith August
PURPOSE: Obstructive sleep apnea (OSA) patients with retrognathia and measurable anatomic airway determinants may represent a subset of OSA patients and have distinct comorbidity profiles. Our aim was to compare the medical comorbidities of OSA patients managed surgically with maxillomandibular advancement with those of nonsurgical patients. PATIENTS AND METHODS: In this cross-sectional retrospective study, patients for both cohorts were identified through the Massachusetts General Hospital oral and maxillofacial surgery data registry and the Massachusetts General Hospital Research Patient Data Registry...
January 31, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29423748/evaluation-of-the-success-of-obstructive-sleep-apnea-surgery-using-criteria-based-on-long-term-symptoms-and-incident-hypertension
#8
Jae Hyun Lim, Pona Park, Jee Hye Wee, January E Gelera, Kundan Kumar Shrestha, Chae-Seo Rhee, Jeong-Whun Kim
OBJECTIVE: To identify appropriate success criteria, based on long-term symptoms and incident hypertension, after surgery for obstructive sleep apnea (OSA). METHODS: This observational cohort study included 97 adult OSA patients (90 men) who underwent surgical treatment at our tertiary medical center. Subjective symptoms [witnessed sleep apnea and snoring, and Epworth sleepiness scale (ESS) scores] were evaluated through a telephone survey, and incident hypertension was assessed from medical records...
February 8, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29422547/concurrent-presence-of-obstructive-sleep-apnea-and-elevated-homocysteine-levels-exacerbate-the-development-of-hypertension-a-koges-six-year-follow-up-study
#9
Jinkwan Kim, Seung Ku Lee, Dae Wui Yoon, Chol Shin
Accumulating evidence has revealed that obstructive sleep apnea (OSA) and high homocysteine (Hcy) levels play important roles in the increased risk of hypertension and cardiovascular disease. We investigated whether the presence of elevated Hcy levels among individuals with OSA increase the risk of hypertension in a cohort study. A total of 1825 participants were selected from the cohort study. A high homocysteine level (Hcy) was defined as those in the 75th percentile of Hcy levels of the study cohort. The prevalence of hypertension was higher among subjects with OSA and high Hcy levels than among the other groups stratified by the presence of OSA and high Hcy levels...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29415800/short-sleep-duration-is-weakly-associated-with-carotid-intima-media-thickness-in-adolescents
#10
Jade Wing Sum Li, Chun Ting Au, Kate Ching Ching Chan, Ping Chook, Yun Kwok Wing, Albert Martin Li
OBJECTIVE: To investigate the relationship between sleep duration and carotid intima-media thickness (CIMT) in adolescents. We hypothesized that short sleep duration was associated with an increased CIMT. STUDY DESIGN: This was a cross-sectional study. Healthy participants aged 10-18 years were recruited from a school-based cohort established to examine the prevalence of obstructive sleep apnea in Hong Kong. All participants completed a prospective 7-day sleep diary, underwent anthropometric measurements, overnight polysomnography, and CIMT assessment...
February 5, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29413512/the-revised-gold-2017-copd-categorization-in-relation-to-comorbidities
#11
Kathrin Kahnert, Peter Alter, David Young, Tanja Lucke, Joachim Heinrich, Rudolf M Huber, Jürgen Behr, Margarethe Wacker, Frank Biertz, Henrik Watz, Robert Bals, Tobias Welte, Hubert Wirtz, Felix Herth, Jørgen Vestbo, Emiel F Wouters, Claus F Vogelmeier, Rudolf A Jörres
INTRODUCTION: The COPD classification proposed by the Global Initiative for Obstructive Lung Disease was recently revised, and the A to D grouping is now based on symptoms and exacerbations only. Potential associations with comorbidities have not been assessed so far. Thus the aim of the present study was to determine the relationship between the revised (2017) GOLD groups A-D and major comorbidities. METHODS: We used baseline data from the COPD cohort COSYCONET...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29406938/metabolic-syndrome-systems-thinking-in-heart-disease
#12
REVIEW
Ron Dommermuth, Kristine Ewing
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors. MetS is associated with approximately 4-fold increase in the likelihood of developing type 2 diabetes mellitus (T2DM) and a 2-fold increase in the incidence of cardiovascular disease complications. MetS is a progressive, proinflammatory, prothrombotic condition that manifests itself along a broad spectrum of disease. It is associated with hypertension, obstructive sleep apnea, fatty liver disease, gout, and polycystic ovarian syndrome. Intervening in and reversing the pathologic process become more difficult as the disease progresses, highlighting the needs for increased individual and community surveillance and primary prevention...
March 2018: Primary Care
https://www.readbyqxmd.com/read/29390281/comparison-of-safety-and-effectiveness-between-laparoscopic-mini-gastric-bypass-and-laparoscopic-sleeve-gastrectomy-a-meta-analysis-and-systematic-review
#13
Fu-Gang Wang, Zhao-Peng Yu, Wen-Mao Yan, Ming Yan, Mao-Min Song
BACKGROUND: The laparoscopic mini-gastric bypass is a newly emerged surgical procedure in recent years. Owe to safe and simple process and effective outcomes, laparoscopic mini-gastric bypass has quickly become one of the most popular procedures in some countries. The safety and effectiveness of laparoscopic mini-gastric bypass versus laparoscopic sleeve gastrectomy remain unclear. METHODS: A systematic literature search was performed in PubMed, Embase, Cochrane library from inception to May 20, 2017...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29373256/severe-obstructive-sleep-apnea-in-children-with-elevated-blood-pressure
#14
Jane Hinkle, Heidi V Connolly, Heather R Adams, Marc B Lande
The objective was to determine the prevalence of habitual snoring and obstructive sleep apnea (OSA) in a cohort of children referred for elevated blood pressure (BP), and to determine the association between OSA and BP elevation, learning difficulties, and behavioral problems. We performed a retrospective review of 446 consecutive new patients referred for elevated BP. One hundred four (23%) had habitual snoring. Patients with habitual snoring were more likely to be obese (86.5 vs. 55.6%, P < .001) and to have Medicaid insurance (52...
January 3, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29368965/consensus-statement-by-the-american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-on-the-comprehensive-type-2-diabetes-management-algorithm-2018-executive-summary
#15
Alan J Garber, Martin J Abrahamson, Joshua I Barzilay, Lawrence Blonde, Zachary T Bloomgarden, Michael A Bush, Samuel Dagogo-Jack, Ralph A DeFronzo, Daniel Einhorn, Vivian A Fonseca, Jeffrey R Garber, W Timothy Garvey, George Grunberger, Yehuda Handelsman, Irl B Hirsch, Paul S Jellinger, Janet B McGill, Jeffrey I Mechanick, Paul D Rosenblit, Guillermo E Umpierrez
A1C = hemoglobin A1C; AACE = American Association of Clinical Endocrinologists; ACCORD = Action to Control Cardiovascular Risk in Diabetes; ACCORD BP = Action to Control Cardiovascular Risk in Diabetes Blood Pressure; ACEI = angiotensin-converting enzyme inhibitor; ADVANCE = Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation; AGI = alpha-glucosidase inhibitor; apo B = apolipoprotein B; ASCVD = atherosclerotic cardiovascular disease; BAS = bile acid sequestrant; BCR-QR = bromocriptine quick release; BMI = body mass index; BP = blood pressure; CCB = calcium channel blocker; CHD = coronary heart disease; CKD = chronic kidney disease; CVD = cardiovascular disease; DASH = Dietary Approaches to Stop Hypertension; DPP4 = dipeptidyl peptidase 4; eGFR = estimated glomerular filtration rate; ER = extended release; FDA = Food and Drug Administration; GLP1 = glucagon-like peptide 1; HDL-C = high-density lipoprotein cholesterol; IMPROVE-IT = Improved Reduction of Outcomes: Vytorin Efficacy International Trial; LDL-C = low-density lipoprotein cholesterol; LDL-P = low-density lipoprotein particle; Look AHEAD = Look Action for Health in Diabetes; NPH = neutral protamine Hagedorn; OSA = obstructive sleep apnea; RCT = randomized controlled trial; SU = sulfonylurea; SGLT2 = sodium glucose cotransporter-2; SMBG = self-monitoring of blood glucose; T2D = type 2 diabetes; TZD = thiazolidinedione; VADT = Veterans Affairs Diabetes Trial...
January 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29368899/-obesity-hypoventilation-syndrome-and-pulmonary-hypertension-an-association-little-known-in-mexico
#16
Ernesto Díaz-Domínguez, Martín Rosas-Peralta, Luis Efrén Santos-Martínez, Nielzer Armando Rodríguez-Almendros, José Antonio Magaña-Serrano, Gilberto Pérez-Rodríguez
The obesity hypoventilation syndrome (OHS) refers to the combination of obesity, daytime hypercapnia and sleep-disordered breathing. Obesity has risen to epidemic proportions in the last three decades in the United States, Mexico and Europe. The OHS is associated with obstructive sleep apnea syndrome in 30%. Without treatment, mortality is 46% at 50 months. So in this paper we analyze the OHS, obesity and pulmonary hypertension, the pathophysiology, clinical presentation and diagnosis as well as the treatment, which is aimed at the correction of sleep-disordered breathing and hypoxemia; although there is little experience with the use of specific pulmonary vasodilator drugs...
January 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29363362/sleep-disordered-breathing-in-pregnant-women-maternal-and-fetal-risk-treatment-considerations-and-future-perspectives
#17
Kimberly Truong, Christian Guilleminault
Numerous physiologic and anatomic changes during pregnancy exacerbate or unmask obstructive sleep apnea in women. Left untreated, upper airway flow limitation during pregnancy may lead to dire maternal and fetal health consequences. Areas covered: This review outlines the relationship between sleep disordered breathing (SDB) and gestational hypertension, preeclampsia, and gestational diabetes. It also discusses the implications of SDB on fetal and maternal health and concludes with a review of the emerging literature of treatment options for SDB in pregnancy and its benefit...
January 24, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29359806/the-role-of-hypoxia-inducible-factors-in-carotid-body-patho-physiology
#18
Gregg L Semenza, Nanduri R Prabhakar
Hypoxia-inducible factors mediate adaptive responses to reduced O2 availability. In patients with obstructive sleep apnea, repeated episodes of hypoxemia and reoxygenation (intermittent hypoxia) are sensed by the carotid body (CB). The ensuing CB chemosensory reflex activates the sympathetic nervous system and increased secretion of catecholamines by the adrenal medulla, resulting in hypertension and breathing abnormalities. In the CB, intermittent hypoxia induces the formation of reactive oxygen species (ROS) and increased intracellular Ca2+ levels, which drive increased expression of hypoxia-inducible factor 1α (HIF-1α) and a decrease in the levels of HIF-2α...
January 23, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29359203/rare-undiagnosed-primary-amyloidosis-unmasked-during-surgical-treatment-of-primary-hyperparathyroidism-a-case-report
#19
Kathleen C Gallagher, Ariana B Geromes, John Stokes, India A Reddy, James S Lewis, Naira Baregamian
Primary amyloidosis (PA) is a protein deposition disorder that presents with localized or multisystemic disease. The incidence is low in the general public, ranging from three to eight cases per million, and with nonspecific presenting symptoms typically occurring later in life. Due to late presentation, substantial and irreversible damage has usually already occurred by the time of the diagnosis. However, if inadvertent diagnosis occurs before irreversible damage has taken place, as it did in the following case, some patients may benefit from the disease-arresting treatment...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29339206/objective-sleep-measures-in-subacute-stroke-inpatients-associated-with-levels-and-improvements-in-activities-of-daily-living
#20
Ren-Jing Huang, Ching-Hsiang Lai, Shin-Da Lee, Fang-Yu Pai, Shen-Wen Chang, Ai-Hui Chung, Yi-Fang Chang, Hua Ting
OBJECTIVE: To investigate whether objective polysomnographic measures of prevalent sleep problems such as sleep-disordered-breathing (SDB) and insomnia are associated with activities of daily living levels in inpatients at rehabilitation units DESIGN: Retrospective and observational study SETTING: Single rehabilitation center PARTICIPANTS: One hundred twenty-three enrolled subacute stroke inpatients (61.6 ± 13.1 years; 23.8 ± 3.4 kg/m2; 33% female; 90.5 ± 36.7 days post-stroke) underwent a one-night polysomnography study and one-month-long inpatient rehabilitation program...
January 12, 2018: Archives of Physical Medicine and Rehabilitation
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