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https://www.readbyqxmd.com/read/27914359/obstructive-sleep-apnea-and-arrhythmia-a-systemic-review
#1
EDITORIAL
Nirav Patel, Caroline Donahue, Abhishek Shenoy, Arpan Patel, Nabil El-Sherif
There is a growing consensus in the scientific community that suggests a strong association between obstructive sleep apnea (OSA) and cardiovascular (CVD) conditions and events, including coronary artery disease, hypertension, arrhythmia, heart failure, and sudden cardiac death. We reviewed evidence on the relationship between OSA and arrhythmia. Our conclusion, based on our review of the literature, is that the evidence supports a strong link between OSA and cardiovascular mortality, which warrants treating OSA...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27909488/atrial-fibrillation-and-sleep-apnea-considerations-for-a-dual-epidemic
#2
REVIEW
Patricia Tung Md, Elad Anter Md
Atrial fibrillation (AF) is the most common cardiac arrhythmia and shares many of the same risk factors as another common clinical condition, sleep apnea. The estimated prevalence of sleep apnea has increased over the past decade, and reflects a parallel increase in the most prominent risk factors of obesity and overweight. Both obstructive and central sleep apnea have been associated with AF in multiple studies, with the risk of AF increasing 2-4-fold compared to those without sleep breathing disorder. Continuous positive airway pressure (CPAP) has been shown to reduce the rate of AF recurrence following catheter ablation in patients with sleep apnea...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27837155/monocyte-count-hdl-cholesterol-ratio-and-cardiovascular-disease-in-patients-with-obstructive-sleep-apnea-syndrome-a-multicenter-study
#3
Handan Inonu Koseoglu, Ahmet Cemal Pazarli, Asiye Kanbay, Osman Demir
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular disease (CVD). Although monocyte to high-density lipoprotein cholesterol ratio (MHR) is increasingly being implicated in cardiovascular morbidity and mortality, no study has attempted to determine the role of MHR in cardiovascular morbidity of patients with OSAS. We aimed to investigate the association between MHR and CVD in patients with OSAS and the relationship between severity of OSAS, polysomnographic parameters, and MHR...
November 11, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27800512/chronic-intermittent-hypoxia-and-obstructive-sleep-apnea-an-experimental-and-clinical-approach
#4
REVIEW
Emilia Sforza, Fréderic Roche
Obstructive sleep apnea (OSA) is a prevalent sleep disorder considered as an independent risk factor for cardiovascular consequences, such as systemic arterial hypertension, ischemic heart disease, cardiac arrhythmias, metabolic disorders, and cognitive dysfunction. The pathogenesis of OSA-related consequence is assumed to be chronic intermittent hypoxia (IH) inducing alterations at the molecular level, oxidative stress, persistent systemic inflammation, oxygen sensor activation, and increase of sympathetic activity...
2016: Hypoxia
https://www.readbyqxmd.com/read/27753673/a-narrative-review-of-how-sleep-related-breathing-disorders-and-cardiovascular-diseases-are-linked-an-update-for-advanced-practice-registered-nurses
#5
Chooza Moon, Cynthia H Phelan, Diane R Lauver, Lisa C Bratzke
PURPOSE/OBJECTIVES: Sleep-related breathing disorders (SRBDs), including obstructive sleep apnea and central sleep apnea, are common among patients with cardiovascular disease (CVD), but clinicians often do not pay enough attention to SRBDs. The purpose of this narrative review is to update advanced practice registered nurses on the literature focusing on the relationship between SRBDs and CVD (eg, hypertension, heart failure, coronary artery disease, arrhythmias, and stroke) and on treatments that can improve SRBDs in patients with CVD...
November 2016: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/27717951/-does-the-presence-of-an-obstructive-sleep-apnea-change-the-indications-for-the-pacemaker-implantation-case-raports
#6
Katarzyna Foryś, Mariusz Foryś, Katarzyna Piotrowicz
The obstructive sleep apnea (OSA) is a mortality risk factor of the cardiovascular system diseases. One of the elements of this relationship is the occurrence of nocturnal cardiac arrhythmias. The arrhytmias in question are resistant to drug therapy so it is suggested to consider electrotherapy. However, the coexistence of OSA and thus recurrent episodes of nocturnal hypoxia, may have significant impact on the diagnosis and the treatment applied as shown in the following cases. In some cases, the decision of electrotherapy should be preceded by the use of therapy with continuous positive airway pressure (CPAP)...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27712142/chronic-obstructive-airway-disease-among-patients-hospitalized-with-acute-heart-failure-clinical-characteristics-precipitating-factors-management-and-outcome-observational-report-from-the-middle-east
#7
Hadi A R Khafaji, Kadhim Sulaiman, Rajvir Singh, Khalid F Alhabib, Nidal Asaad, Alawi Alsheikh-Ali, Mohammed Al-Jarallah, Bassam Bulbanat, Wael Almahmeed, Mustafa Ridha, Nooshin Bazargani, Haitham Amin, Ahmed Al-Motarreb, Husam Al Faleh, Abdelfatah Elasfar, Prashanth Panduranga, Jassim Al Suwaidi
BACKGROUND: The purpose of this study was to report the prevalence, clinical characteristics, contributing factors, management and outcome of patients with chronic obstructive pulmonary disease (COPD) among patients hospitalized with heart failure (HF). METHODS: Data were derived from Gulf Care (Gulf acute heart failure registry), a prospective multicenter study of 5005 consecutive patients hospitalized with acute heart failure during February to November 2012 in seven Middle Eastern countries...
December 2015: Acute Cardiac Care
https://www.readbyqxmd.com/read/27693594/obstructive-sleep-apnea-and-cardiac-arrhythmogenesis-mechanistic-insights
#8
Anna M May, David R Van Wagoner, Reena Mehra
A surge of data has reproducibly identified strong associations of obstructive sleep apnea (OSA) with cardiac arrhythmias. As an extension of epidemiologic and clinic-based findings, experimental investigations have made strides in advancing our understanding of the putative OSA and cardiac arrhythmogenesis mechanistic underpinnings. While most studies have focused on the links between OSA and atrial fibrillation (AF), relationships with ventricular arrhythmias have also been characterized. Key findings implicate OSA-related autonomic nervous system fluctuations typified by enhanced parasympathetic activation during and sympathetic surges subsequent to respiratory events which contribute to augmented arrhythmic propensity...
September 29, 2016: Chest
https://www.readbyqxmd.com/read/27636935/-a-clinical-case-of-hemangioma-of-the-face-and-tongue-concurrent-with-severe-obstructive-sleep-apnea-syndrome-complicated-by-cardiac-arrhythmias-and-conduction-disturbances
#9
K I Konovalova, E M Elfimova, E A Butorova, A V Aksenova, P V Galitsin, O S Bulkina, A Yu Litvin, I E Chazova
The paper describes a clinical case of a female patient with severe obstructive sleep apnea syndrome in the presence of congenital hemangioma of the face, soft palate, and tongue concurrent with paroxysmal atrial fibrillation and atrial flutter, paroxysmal supraventricular tachycardia, and sinoatrial block (maximally up to 3.9 sec). Continuous positive airway pressure therapy could reduce the number of paroxysms of atrial fibrillation and atrial flutter, supraventricular tachycardia and eliminate sinoatrial block...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27633331/serum-interleukin-6-association-with-circulating-cytokine-serum-levels-in-patients-with-sinus-arrhythmia-and-patients-with-coronary-artery-disease
#10
A L Shim, A A Aksyonov, V M Mitrokhin, I B Lovchikova, M A Konoplyannikov, A V Konev, A S Zotov, R S Ovchinnikov, E Antova, M I Mladenov, A Kamkin
In this study, we were focused on the differences between certain circulating cytokine levels in patients with or without sinus arrhythmia, according to the median IL-6 level. All patients were stable with regards to symptoms and therapy for at least one month prior to the measurements conducted within this study.Exclusion criteria were: patients with sleep apnea, asthma, respiratory insufficiency of any genesis, active infection, allergy, inflammatory diseases, cancer, diabetes of any type and treatment with anti-inflammatory drugs...
September 9, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27625463/is-obstructive-sleep-apnea-more-common-in-adults-with-arrhythmias
#11
Vishisht Mehta, Anurati Mehta, Yash Lokhandwala, Sanjeev Mehta
No abstract text is available yet for this article.
September 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27583421/diagnosis-and-treatment-of-obstructive-sleep-apnea-in-adults
#12
Michael Semelka, Jonathan Wilson, Ryan Floyd
Obstructive sleep apnea is a common disorder that causes patients to temporarily stop or decrease their breathing repeatedly during sleep. This results in fragmented, nonrestful sleep that can lead to symptoms such as morning headache and daytime sleepiness. Obstructive sleep apnea affects persons of all ages, with an increasing prevalence in those older than 60 years. The exact prevalence is unknown but is estimated to be between 2% and 14%. There are many health conditions associated with obstructive sleep apnea, including hypertension, coronary artery disease, cardiac arrhythmias, and depression...
September 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27545027/-cluster-analysis-of-the-clinical-presentations-in-patients-with-moderate-to-severe-obstructive-sleep-apnea-syndrome-and-its-significance
#13
S Tang, X F Zhou, K Hu, L F Xu, J X Yu, H M Li
OBJECTIVE: To analyze subtypes of the clinical presentation of moderate-to-severe obstructive sleep apnea syndrome (OSAS) by cluster analysis and to explore its significance. METHODS: A retrospective analysis was performed on the data of adult moderate-to-severe OSAS patients, which were diagnosed in Respiratory Department, Renmin Hospital of Wuhan University from October 2012 to October 2015. Fifteen kinds of clinical presentations were included in the cluster analysis, and analysis of characteristic of each cluster was then performed after category...
August 9, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27543307/obstructive-sleep-apnea-and-circulating-potassium-channel-levels
#14
Ning Jiang, Anyu Zhou, Bharati Prasad, Li Zhou, Jimmy Doumit, Guangbin Shi, Hafiz Imran, Bahaa Kaseer, Richard Millman, Samuel C Dudley
BACKGROUND: Cardiac arrhythmias and sudden cardiac death are more frequent in patients with obstructive sleep apnea (OSA). OSA is associated with QT prolongation, and QT prolongation is an independent risk factor for sudden cardiac death. Because QT prolongation can be mediated by potassium channel loss of function, we tested whether OSA or continuous positive airway pressure therapy altered mRNA expression of circulating white blood cell potassium channels. METHODS AND RESULTS: In total, 28 patients with OSA newly diagnosed by polysomnogram and 6 participants without OSA were enrolled...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27462054/ablation-of-atrial-fibrillation-patient-selection-periprocedural-anticoagulation-techniques-and-preventive-measures-after-ablation
#15
Mark S Link, Michel Haïssaguerre, Andrea Natale
Atrial fibrillation (AF) is the most common arrhythmia encountered by cardiologists and is a major cause of morbidity and mortality. Risk factors for AF include age, male sex, genetic predisposition, hypertension, diabetes mellitus, sleep apnea, obesity, excessive alcohol, smoking, hyperthyroidism, pulmonary disease, air pollution, heart failure, and possibly excessive exercise. The management of AF involves decisions about rate versus rhythm control. Asymptomatic patients are generally managed with rate control and anticoagulation...
July 26, 2016: Circulation
https://www.readbyqxmd.com/read/27449231/apneic-events-a-proposed-new-target-for-respiratory-safety-pharmacology
#16
Dennis J Murphy
Current practice in respiratory safety pharmacology generally follows the regulatory guidance provided by the ICH document S7A and focuses on measures of pulmonary ventilation. What these measures do not account for is the ability of drugs to cause ventilatory instability or interruptions in ventilatory rhythm. Ventilatory instability can be identified by the presence of prolonged end-expiratory pauses or apneic periods. An apneic event has been defined as an apneic period of sufficient duration to cause hypoxia (i...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27397854/sleep-sleep-deprivation-autonomic-nervous-system-and-cardiovascular-diseases
#17
Eleonora Tobaldini, Giorgio Costantino, Monica Solbiati, Chiara Cogliati, Tomas Kara, Lino Nobili, Nicola Montano
Sleep deprivation (SD) has become a relevant health problem in modern societies. We can be sleep deprived due to lifestyle habits or due to sleep disorders, such as insomnia, obstructive sleep apnea (OSA) and neurological disorders. One of the common element of sleep disorders is the condition of chronic SD, which has complex biological consequences. SD is capable of inducing different biological effects, such as neural autonomic control changes, increased oxidative stress, altered inflammatory and coagulatory responses and accelerated atherosclerosis...
July 7, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27381902/carotid-body-ablation-abrogates-hypertension-and-autonomic-alterations-induced-by-intermittent-hypoxia-in-rats
#18
Rodrigo Del Rio, David C Andrade, Claudia Lucero, Paulina Arias, Rodrigo Iturriaga
Chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea, enhances carotid body (CB) chemosensory responses to hypoxia and produces autonomic dysfunction, cardiac arrhythmias, and hypertension. We tested whether autonomic alterations, arrhythmogenesis, and the progression of hypertension induced by CIH depend on the enhanced CB chemosensory drive, by ablation of the CB chemoreceptors. Male Sprague-Dawley rats were exposed to control (Sham) conditions for 7 days and then to CIH (5% O2, 12/h 8 h/d) for a total of 28 days...
August 2016: Hypertension
https://www.readbyqxmd.com/read/27380998/biomarkers-of-cardiovascular-stress-in-obstructive-sleep-apnea
#19
REVIEW
Micha T Maeder, Christian Mueller, Otto D Schoch, Peter Ammann, Hans Rickli
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder associated with "cardiovascular stress", i.e. cardiovascular risk factors, cardiovascular diseases, and an increased risk of heart failure, stroke, and death. Experimental and clinical studies have characterized potential underlying mechanisms including biventricular dysfunction, atherosclerosis, and arrhythmia. Assessment of these cardiovascular features of OSA requires a spectrum of clinical tools including ECG, echocardiography, exercise testing, and angiography...
September 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27240438/proof-of-concept-study-renal-sympathetic-denervation-for-treatment-of-polymorphic-premature-ventricular-complexes
#20
Márcio Galindo Kiuchi, Gustavo Ramalho E Silva, Luis Marcelo Rodrigues Paz, Shaojie Chen, Gladyston Luiz Lima Souto
BACKGROUND OR PURPOSE: Polymorphic premature ventricular complexes (PVCs) are very common, appearing most frequently in patients with hypertension, obesity, sleep apnea, and structural heart disease. Sympathetic hyperactivity plays a critical role in the development, maintenance, and aggravation of ventricular arrhythmias. Recently, the relevance of sympathetic activation in patients with ventricular arrhythmias was reported, and this finding suggested a potential role for catheter-based renal sympathetic denervation in reducing the arrhythmic burden...
May 30, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
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