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https://www.readbyqxmd.com/read/29746310/beneficial-response-of-blood-pressure-to-short-term-continuous-positive-airway-pressure-in-chinese-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#1
Xiao Wang, Jian Qiu, Yufeng Wang, Zechuan Cai, Xiaoxia Lu, Taoping Li
BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is common in people with hypertension and cardiac rhythm disorder. The objectives of this study were to determine the effect of short-term continuous positive airway pressure (CPAP) on blood pressure (BP) and cardiac rhythm in Chinese patients with moderate to severe OSAHS. PATIENTS AND METHODS: Eligible patients in the two hospitals were consecutively enrolled into the prospective study. Ambulatory BP monitoring and Holter monitoring were both performed for 24 h in 214 patients who previously encountered a full night polysomnography...
May 9, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29745973/the-prevalence-of-obstructive-sleep-apnea-in-patients-with-atrial-fibrillation
#2
Asmaa M Abumuamar, Paul Dorian, David Newman, Colin M Shapiro
BACKGROUND: Obstructive sleep apnea (OSA) is a systemic disorder associated with significant cardiovascular complications. OSA may play a role in the initiation and worsening of atrial fibrillation (AF). This study aimed to determine the prevalence and clinical predictors of OSA in patients with AF. HYPOTHESIS: OSA is underdiagnosed in a large number of patients with AF and may not be predicted by conventional clinical indices. METHODS: Consecutive nonselected patients with AF were recruited from different arrhythmia clinics in Toronto, Ontario, Canada...
May 10, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29740701/characteristics-and-circadian-distribution-of-cardiac-arrhythmias-in-patients-with-heart-failure-and-sleep-disordered-breathing
#3
Hazem Omran, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg, Henrik Fox
BACKGROUND: Cardiac arrhythmias and sleep-disordered breathing (SDB) are common comorbidities in heart failure with reduced ejection fraction (HFrEF). However, understanding of the association between arrhythmias and SDB is poor. This study assessed the occurrence and circadian distribution of ventricular arrhythmias in HFrEF patients with and without SDB. METHODS: This retrospective analysis included HFrEF patients admitted for unattended overnight cardiorespiratory polygraphy and 24-h Holter-ECG recording...
May 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29731622/chronic-obstructive-pulmonary-disease-severity-and-its-association-with-obstructive-sleep-apnea-syndrome-impact-on-cardiac-autonomic-modulation-and-functional-capacity
#4
Katiany Thays Lopes Zangrando, Renata Trimer, Luiz Carlos Soares de Carvalho, Guilherme Peixoto Tinoco Arêas, Flávia Cristina Rossi Caruso, Ramona Cabiddu, Meliza Goi Roscani, Fabíola Paula Galhardo Rizzatti, Audrey Borghi-Silva
Background: The study was conducted to determine the impact of chronic obstructive pulmonary disease (COPD) in association with obstructive sleep apnea syndrome (OSAS) on cardiac autonomic control and functional capacity. Subjects and methods: The study was a cross-sectional prospective controlled clinical study. Heart rate variability indices of 24 COPD (n = 12) and COPD+OSAS (n = 12) patients were evaluated and compared by electrocardiographic recordings acquired during rest, active postural maneuver (APM), respiratory sinus arrhythmia maneuver (RSA-m), and the 6-minute walk test (6MWT)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29726590/changes-in-the-parameters-of-ventricular-repolarization-during-pre-apnea-apnea-and-post-apnea-periods-in-patients-with-obstructive-sleep-apnea
#5
Erdoğan Sökmen, Sinan Cemgil Özbek, Mustafa Çelik, Serkan Sivri, Mehmet Metin, Mustafa Avcu
BACKGROUND: Ventricular arrhythmias are reported to be more common in patients with obstructive sleep apnea (OSA). Preliminary evidence showed such parameters regarding ventricular repolarization as Tp-e, Tp-e/QT and Tp-e/QTc may be related with increased cardiac arrhythmias and even sudden cardiac death. The purpose of the present study was to evaluate ventricular repolarization during immediately pre-apnea period, apnea period and postapnea hyperventilation period in patients with OSA...
May 4, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29698642/obesity-and-ventricular-repolarization-a-comprehensive-review
#6
REVIEW
Jad Omran, Brian P Bostick, Albert K Chan, Martin A Alpert
Obesity is known to be a strong predictor of sudden cardiac death. For this reason, concern exists that this association may be related to delayed ventricular repolarization (VR), which has been extensively studied in overweight and obese patients. The corrected QT interval (QTc) and QT or QTc dispersion have been the most commonly-used electrocardiographic methods for assessing VR. Multiple controlled studies demonstrated that QTc and QT or QTc dispersion were significantly longer/greater in overweight and obese subjects than in normal weight controls...
April 23, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29685205/may-inflammatory-markers-be-used-for-monitoring-the-continuous-positive-airway-pressure-effect-in-patients-with-obstructive-sleep-apnea-and-arrhythmias
#7
G N Dediu, C C Diaconu, S Dumitrache Rujinski, M A Iancu, L A Balaceanu, I Dina, M Bogdan
INTRODUCTION: Obstructive sleep apnea syndrome (OSAS) is defined by recurrent episodes of significant reduction or absence of the oro-nasal airflow during sleep, in the presence of thorax and abdominal movements and snoring. The pathophysiological consequences of intermittent hypoxia determined by OSAS are represented by systemic inflammation, the release of free oxygen radicals and activation of the sympathetic nervous system. Cardiac arrhythmias are a frequent comorbidity in patients with OSAS...
June 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29682848/the-stop-bang-questionnaire-shows-an-insufficient-specificity-for-detecting-obstructive-sleep-apnea-in-patients-with-atrial-fibrillation
#8
Asmaa M Abumuamar, Paul Dorian, David Newman, Colin M Shapiro
Obstructive sleep apnea (OSA) is a sleep disorder associated with significant cardiovascular comorbidities, including cardiac arrhythmia. The STOP-BANG questionnaire is an eight-item self-report questionnaire designed to screen patients for OSA and was validated in preoperative surgical patients. The STOP items are snoring, daytime tiredness, observed apneas and high blood pressure. The BANG items are body mass index >35 kg/m2 , age >50 years, neck circumference >40 cm and male gender. We aimed to determine the screening properties of the STOP-BANG questionnaire in patients with arrhythmia...
April 22, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29680416/electrocardiographic-variables-in-children-with-syndromic-craniosynostosis-and-primary-snoring-to-mild-obstructive-sleep-apnea-significance-of-identifying-respiratory-arrhythmia-during-sleep
#9
Ellaha Kakar, Linda J A Corel, Robert C Tasker, Robbin de Goederen, Eppo B Wolvius, Irene M J Mathijssen, Koen F M Joosten
BACKGROUND: In the spectrum of children with symptomatic sleep disordered breathing (SDB), some individuals - such as those with upper airway resistance syndrome (UARS) - do not have abnormalities on polysomnography (PSG). In this study we have assessed whether assessment of respiratory arrhythmia (RA) and heart rate variability (HRV) analysis helps in management of children with syndromic craniosynostosis and none-to-mild obstructive sleep apnea (OSA). METHODS: Prospective cohort study in children aged 1-18 years old with syndromic craniosynostosis...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29652543/cardioprotection-by-intermittent-hypoxia-conditioning-evidence-mechanisms-and-therapeutic-potential
#10
Robert T Mallet, Eugenia B Manukhina, Steven S Ruelas, James L Caffrey, H Fred Downey
The calibrated application of limited duration, cyclic, moderately intense hypoxia-reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These intermittent hypoxic conditioning (IHC) programs consistently produce striking reductions in myocardial infarction and ventricular tachyarrhythmias following coronary artery occlusion and reperfusion, and in many cases, improved contractile function and coronary blood flow. These IHC protocols are fundamentally different from those used to simulate sleep apnea, a recognized cardiovascular risk factor...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29623136/the-effects-of-continuous-positive-airway-pressure-on-premature-ventricular-contractions-and-ventricular-wall-stress-in-patients-with-heart-failure-and-sleep-apnea
#11
Sabri Seyis, Adnan Kazım Usalan, Ibrahim Rencuzogullari, Özge Kurmuş, Adil Can Gungen
Background: We aimed to investigate the effects of continuous positive airway pressure (CPAP) treatment on electrocardiography (ECG), premature ventricular contraction load on 24-hour Holter recordings, and implantable cardioverter defibrillator (ICD) shocks in patients with obstructive sleep apnea syndrome (OSAS) and heart failure. Methods: Patients with heart failure and ICD and patients with newly diagnosed OSAS were divided into two groups according to CPAP treatment...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29533258/patients-at-high-risk-for-obstructive-sleep-apnea-are-at-increased-risk-for-atrial-fibrillation-after-cardiac-surgery-a-cohort-analysis
#12
Nika Karimi, Marta Kelava, Perin Kothari, Nicole M Zimmerman, A Marc Gillinov, Andra E Duncan
BACKGROUND: Patients with obstructive sleep apnea (OSA) experience intermittent hypoxia, hypercarbia, and sympathetic activation during sleep, which increases risk for paroxysmal atrial fibrillation and other cardiac arrhythmias. Whether patients with OSA experience increased episodes of atrial fibrillation after cardiac surgery is unclear. We examined whether patients at increased risk for OSA, assessed by the STOP-BANG (snoring, tired during the day, observed stop breathing during sleep, high blood pressure, body mass index more than 35 kg/m, age more than 50 years, neck circumference more than 40 cm, and male gender) questionnaire, had a higher incidence of new-onset postoperative atrial fibrillation after cardiac surgery...
March 12, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29458741/sleep-disordered-breathing-is-associated-with-disturbed-cardiac-repolarization-in-patients-with-a-coronary-artery-bypass-graft-surgery
#13
Christina Schmidleitner, Michael Arzt, Maria Tafelmeier, Sarah Ripfel, Miriam Fauser, Teresa Weizenegger, Bernhard Flörchinger, Daniele Camboni, Sigrid Wittmann, Florian Zeman, Christof Schmid, Lars S Maier, Stefan Wagner, Christoph Fisser
BACKGROUND: The development of malignant ventricular arrhythmias due to abnormal cardiac repolarization is a major complication after coronary artery bypass graft surgery (CABG). Sleep-disordered breathing (SDB) is linked to prolonged cardiac repolarization in non-surgical patients. This study evaluates cardiac repolarization in patients with and without SDB who underwent CABG. METHODS: 100 patients who had received CABG (84% men, age 68 ± 10 years, body-mass-index [BMI] 28...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29445096/chronic-intermittent-hypoxia-promotes-myocardial-ischemia-related-ventricular-arrhythmias-and-sudden-cardiac-death
#14
Jessica Morand, Claire Arnaud, Jean-Louis Pepin, Diane Godin-Ribuot
We investigated the effects of intermittent hypoxia (IH), such as that encountered in severe obstructive sleep apnea (OSA) patients, on the development and severity of myocardial ischemia-related ventricular arrhythmias. Rats were exposed to 14 days of IH (30 s at 5%O2 and 30 s at 21%O2 , 8 h·day-1 ) or normoxia (N, similar air-air cycles) and submitted to a 30-min coronary ligature. Arterial blood pressure (BP) and ECG were recorded for power spectral analysis, ECG interval measurement and arrhythmia quantification...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29429026/modulation-of-renal-sympathetic-innervation-recent-insights-beyond-blood-pressure-control
#15
REVIEW
Dominik Linz, Mathias Hohl, Adrian D Elliott, Dennis H Lau, Felix Mahfoud, Murray D Esler, Prashanthan Sanders, Michael Böhm
Renal afferent and efferent sympathetic nerves are involved in the regulation of blood pressure and have a pathophysiological role in hypertension. Additionally, several conditions that frequently coexist with hypertension, such as heart failure, obstructive sleep apnea, atrial fibrillation, renal dysfunction, and metabolic syndrome, demonstrate enhanced sympathetic activity. Renal denervation (RDN) is an approach to reduce renal and whole body sympathetic activation. Experimental models indicate that RDN has the potential to lower blood pressure and prevent cardio-renal remodeling in chronic diseases associated with enhanced sympathetic activation...
February 10, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29424572/atrial-arrhythmias-and-autonomic-dysfunction-in-rats-exposed-to-chronic-intermittent-hypoxia
#16
Sara L Bober, John Ciriello, Douglas L Jones
Obstructive sleep apnea (OSA), which involves chronic, intermittent hypoxia (CIH), is a major risk factor for developing atrial fibrillation (AF). Whether or not CIH alone alters cardiac mechanisms to support AF is unknown. This study investigated the effects of CIH on atrial electrophysiology and arrhythmia vulnerability, and evaluated the role of autonomics in CIH promotion of AF. Adult male Sprague-Dawley rats were exposed to 8h/day of CIH or normoxia for 7 days. Following exposure, rats were anesthetized for intracardiac electrophysiological studies...
February 9, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29410745/prevalence-and-predictors-of-arrhythmia-in-patients-with-obstructive-sleep-apnea
#17
Aljohara Saud Almeneessier, Nader Alasousi, Munir M Sharif, Seithikurippu R Pandi-Perumal, Ahmad Salah Hersi, Ahmed Salem BaHammam
Objectives: To assess the prevalence and types of arrhythmias in Saudi OSA patients and to identify predictors of arrhythmia in this group of patients. Methods: This case-control study included all patients who underwent level I attended overnight polysomnography between 2009 and 2012. Electrocardiographic data collected during sleep studies of patients with and without OSA were manually reviewed. Results: The study comprised 498 patients (394 OSA patients and 104 non-OSA patients (controls)...
October 2017: Sleep Science
https://www.readbyqxmd.com/read/29343998/rationale-and-design-for-a-monocentric-prospective-study-sleep-apnea-diagnosis-using-a-novel-pacemaker-algorithm-and-link-with-aldosterone-plasma-level-in-patients-presenting-with-diastolic-dysfunction-sapaad-study
#18
Laure Champ-Rigot, Virginie Ferchaud, Jean-Noël Prévost, Pierre Moirot, Arnaud Pellissier, Damien Legallois, Joachim Alexandre, Patrice Scanu, Remy Morello, Eric Saloux, Paul Ursmar Milliez
Previous studies showed good agreement between pacemaker respiratory disturbance index (RDI) and polysomnography for diagnosis of severe sleep apnea (SA). The aim of this study is to investigate the diagnostic accuracy of RDI compared with apnea-hypopnea index (AHI) from a cardiorespiratory sleep study for the diagnosis of severe SA within patients requiring a pacemaker and meeting diastolic dysfunction criteria. Secondary objectives are as follows: correlation between plasma aldosterone level and SA severity, diagnostic accuracy of RDI for moderate SA, prevalence of SA among patients with diastolic dysfunction, occurrence of arrhythmias, and improvement of RDI with continuous positive airway pressure therapy...
2018: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/29250231/laser-catheter-ablation-of-long-lasting-persistent-atrial-fibrillation-longterm-results
#19
Helmut Weber, Michaela Sagerer-Gerhardt, Armin Heinze
Catheter ablation of atrial fibrillation (AF) is a current therapeutic option but its efficacy for the treatment of long-lasting persistent AF (l-lpAF) remains suboptimal. We tested the laser method as an alternative for catheter ablation of l-lpAF by using an open-irrigated electrode laser mapping and ablation (ELMA) catheter. Laser ablation was attempted in 48 patients aged 50-81 years (69 ± 7.6 y, female = 28) with drug resistant (3.5 trials) l-lpAF (≥12 months). All of the patients had comorbidities: congestive heart failure NYHA II-III (100%), hypertension 29 (60%), coronary artery disease 19 (40%), and heart valve defect 17 (35%)...
August 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29231011/-research-progress-of-the-relationship-between-sunds-and-osahs
#20
REVIEW
Y D Wu, L Y Zhang, J D Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is always a difficulty in forensic medicine researches. Although the development of molecular genetics promotes the etiologic study of SUNDS, the pathogenesis of most such cases is still unclear. Sleep apnea syndrome (SAS) is one of the common forms of sleep disorders, and obstructive sleep apnea hypopnea syndrome (OSAHS) is the most common. In recent years, some domestic and international researches show that OSAHS is related to the development of cardiovascular disease, which may cause cardiac arrhythmia, even sudden death...
February 2017: Fa Yi Xue za Zhi
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