keyword
MENU ▼
Read by QxMD icon Read
search

ESKAPE

keyword
https://www.readbyqxmd.com/read/29286008/update-on-the-main-mdr-pathogens-prevalence-and-treatment-options
#1
Silvano Esposito, Giuseppe De Simone
In recent years the proportion of multi-drug resistance (MDR) among the bacterial pathogens causing infections, particularly those acquired in healthcare settings, has risen worryingly worldwide. It poses a serious public health threat as the multiple patterns of resistance limit the effective treatment options for such infections. Although many bacterial species have developed reduced susceptibility to a wide array of antimicrobial molecules, a particular group of pathogens acronymically referred to as ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29261405/evaluation-of-aminoglycoside-and-carbapenem-resistance-in-a-collection-of-drug-resistant-pseudomonas-aeruginosa-clinical-isolates
#2
Selina Y L Holbrook, Sylvie Garneau-Tsodikova
Pseudomonas aeruginosa, a Gram-negative bacterium, is a member of the ESKAPE pathogens and one of the leading causes of healthcare-associated infections worldwide. Aminoglycosides (AGs) are recognized for their efficacy against P. aeruginosa. The most common resistance mechanism against AGs is the acquisition of AG-modifying enzymes (AMEs) by the bacteria, including AG N-acetyltransferases (AACs), AG O-phosphotransferases (APHs), and AG O-nucleotidyltransferases (ANTs). In this study, we obtained 122 multidrug-resistant P...
December 20, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29261091/association-of-enterococcus-spp-with-severe-combat-extremity-injury-intensive-care-and-polymicrobial-wound-infection
#3
Rae A Heitkamp, Ping Li, Katrin Mende, Samandra T Demons, David R Tribble, Stuart D Tyner
BACKGROUND: Combat-related extremity wound infections can complicate the recovery of injured military personnel. The Enterococcus genus contains both commensal and pathogenic bacteria found in many combat wounds. We describe the patient population susceptible to Enterococcus infection, the characteristics of Enterococcus spp. isolated from combat-related wounds, and the microbiological profile of Enterococcus-positive wounds. METHODS: Patient and culture data were obtained from the Trauma Infectious Disease Outcomes Study...
December 20, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29250670/an-overview-of-resistance-profiles-eskape-pathogens-from-2010-2015-in-a-tertiary-respiratory-center-in-romania
#4
Nicolae Ovidiu Peneş, Andrei Alexandru Muntean, Adriana Moisoiu, Mădălina Maria Muntean, Alexandru Chirca, Miron Alexandru Bogdan, Mircea Ioan Popa
Lower respiratory tract infections (LRTIs) is an umbrella term that covers a wide spectrum of diseases, comprising mild and severe, acute and chronic conditions. A wide spectrum of pathogens can be implicated, from viruses to pyogenic and atypical bacteria. A special place should be reserved for slow growing bacteria (Mycobacteria spp., Nocardia spp.) and parasites (i.e., hydatic cysts caused by Echinococcus granulosus). OBJECTIVE: The objective of this study is to observe, analyze and establish the drug susceptibility patterns for Enterococcus spp...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29198700/probing-transport-of-fosfomycin-through-substrate-specific-opro-and-oprp-from-pseudomonas-aeruginosa
#5
Funda Citak, Ishan Ghai, Frank Rosenkötter, Lorraine Benier, Mathias Winterhalter, Richard Wagner
Increasing antimicrobial drug resistance is a global threat especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as an important bottleneck that prevents a sufficient antibacterial effect to be achieved at low doses of the antibiotics. In particular, the outer membrane permeability for negatively charged molecules of the clinical important ESKAPE bacterium Pseudomonas aeruginosa is determined by the low conductance porins OprO and OprP Here we show that the alternative phosphonic-acid antibiotic fosfomycin is highly permeable through the OprO and OprP channels...
November 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29198102/antimicrobial-and-antibiofilm-activity-of-human-milk-oligosaccharides-against-streptococcus-agalactiae-staphylococcus-aureus-and-acinetobacter-baumannii
#6
Dorothy L Ackerman, Kelly M Craft, Ryan S Doster, Jörn-Hendrik Weitkamp, David M Aronoff, Jennifer A Gaddy, Steven D Townsend
In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii...
December 8, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29178633/norfloxacin-salts-of-carboxylic-acids-curtail-planktonic-and-biofilm-mode-of-growth-in-eskape-pathogens
#7
Rene Christena Lowrence, Akshaya Ramakrishnan, Niranjana Sri Sundaramoorthy, Aswin Shyam, Vidhyalakshmi Mohan, Himesh M V Subbarao, Venkatasubramanian Ulaganathan, Thiagarajan Raman, Anand Solomon, Saisubramanian Nagarajan
AIMS: To enhance the antimicrobial and antibiofilm activity of norfloxacin against the planktonic and biofilm mode of growth in ESKAPE pathogens using chemically modified norfloxacin salts. METHODS AND RESULTS: Antimicrobial testing, synergy testing and time kill curve analysis, were performed to evaluate antibacterial effect of norfloxacin carboxylic acid salts against ESKAPE pathogens. In vivo efficacy to reduce bacterial bioburden was evaluated in zebrafish infection model...
November 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29162308/a-novel-series-of-enoyl-reductase-inhibitors-targeting-the-eskape-pathogens-staphylococcus-aureus-and-acinetobacter-baumannii
#8
Jieun Kwon, Tina Mistry, Jinhong Ren, Michael E Johnson, Shahila Mehboob
S. aureus and A. baumannii are among the ESKAPE pathogens that are increasingly difficult to treat due to the rise in the number of drug resistant strains. Novel therapeutics targeting these pathogens are much needed. The bacterial enoyl reductase (FabI) is as potentially significant drug target for developing pathogen-specific antibiotics due to the presence of alternate FabI isoforms in many other bacterial species. We report the identification and development of a novel N-carboxy pyrrolidine scaffold targeting FabI in S...
November 11, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29092042/expanding-the-potential-of-nai-107-for-treating-serious-eskape-pathogens-synergistic-combinations-against-gram-negatives-and-bactericidal-activity-against-non-dividing-cells
#9
Cristina Brunati, Thomas T Thomsen, Eleonora Gaspari, Sonia Maffioli, Margherita Sosio, Daniela Jabes, Anders Løbner-Olesen, Stefano Donadio
Objectives: To characterize NAI-107 and related lantibiotics for their in vitro activity against Gram-negative pathogens, alone or in combination with polymyxin, and against non-dividing cells or biofilms of Staphylococcus aureus. NAI-107 was also evaluated for its propensity to select or induce self-resistance in Gram-positive bacteria. Methods: We used MIC determinations and chequerboard experiments to establish the antibacterial activity of the examined compounds against target microorganisms...
October 30, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29030447/housefly-musca-domestica-and-blow-fly-protophormia-terraenovae-as-vectors-of-colistin-resistance-genes-carrying-bacteria
#10
Jilei Zhang, Jiawei Wang, Li Chen, Afrah Kamal Yassin, Patrick Kelly, Patrick Butaye, Jing Li, Jiansen Gong, Russell Cattley, Kezong Qi, Chengming Wang
Flies have the capacity to transfer pathogens between different environments, acting as one of the most important vectors of human diseases worldwide. In this study, we trapped flies on a university campus and tested them for mobile resistance genes against colistin, a last-resort antibiotic in human medicine for treating clinical infections caused by multidrug-resistant Gram-negative bacteria. Quantitative PCRs we developed showed that 34.1% of Musca domestica (86/252) and 51.1% of Protophormia terraenovae (23/45) were positive for the mcr-1, 1...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29017424/development-of-a-statewide-antibiogram-to-assess-regional-trends-in-antibiotic-resistant-eskape-organisms
#11
Anthony J Guarascio, Laura M Brickett, Timothy J Porter, Nancy D Lee, Erin E Gorse, Jordan R Covvey
BACKGROUND: Hospitals and other facilities utilize antibiograms as tools for optimal antibiotic selection. Currently, no measures compare broad trends on the regional level, despite interest for more comprehensive data, particularly for antibiotic-resistant ESKAPE organisms. OBJECTIVE: To collect and compare regional health-care facility antibiogram data for ESKAPE organisms to form a cumulative antibiogram. METHODS: Health-care facilities were identified using the publicly accessible Pennsylvania Department of Health web site...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28964839/in-silico-screening-and-experimental-validation-reveal-l-adrenaline-as-anti-biofilm-molecule-against-biofilm-associated-protein-bap-producing-acinetobacter-baumannii
#12
Vishvanath Tiwari, Varsha Patel, Monalisa Tiwari
Acinetobacter baumannii, an ESKAPE pathogen, causes various nosocomial infections and has capacity to produce biofilm. Biofilm produced by this bacterium is highly tolerant to environmental factors and different antibiotics. Biofilm-associated protein (Bap) plays a significant role in the biofilm formation by A. baumannii and found in the extra cellular matrix of the biofilm. Therefore, it becomes essential to find a potential drug against Bap that has capacity to inhibit biofilm formation by A. baumannii. In-silico screening, molecular mechanics and molecular dynamics studies identified ZINC00039089 (L-Adrenaline) as an inhibitor for Bap of A...
September 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28953270/real-time-detection-of-eskape-pathogens-by-a-nitroreductase-triggered-fluorescence-turn-on-probe
#13
Shengnan Xu, Qinghua Wang, Qingyang Zhang, Leilei Zhang, Limin Zuo, Jian-Dong Jiang, Hai-Yu Hu
The identification of bacterial pathogens is the critical first step in conquering infection diseases. A novel turn-on fluorescent probe for the selective sensing of nitroreductase (NTR) activity and its initial applications in rapid, real-time detection and identification of ESKAPE pathogens have been reported.
October 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28948099/analysis-of-drug-binding-pockets-and-repurposing-opportunities-for-twelve-essential-enzymes-of-eskape-pathogens
#14
Sadia Naz, Tony Ngo, Umar Farooq, Ruben Abagyan
BACKGROUND: The rapid increase in antibiotic resistance by various bacterial pathogens underlies the significance of developing new therapies and exploring different drug targets. A fraction of bacterial pathogens abbreviated as ESKAPE by the European Center for Disease Prevention and Control have been considered a major threat due to the rise in nosocomial infections. Here, we compared putative drug binding pockets of twelve essential and mostly conserved metabolic enzymes in numerous bacterial pathogens including those of the ESKAPE group and Mycobacterium tuberculosis...
2017: PeerJ
https://www.readbyqxmd.com/read/28928474/using-experimental-evolution-to-identify-druggable-targets-that-could-inhibit-the-evolution-of-antimicrobial-resistance
#15
Heer H Mehta, Amy G Prater, Yousif Shamoo
With multi-drug and pan-drug-resistant bacteria becoming increasingly common in hospitals, antibiotic resistance has threatened to return us to a pre-antibiotic era that would completely undermine modern medicine. There is an urgent need to develop new antibiotics and strategies to combat resistance that are substantially different from earlier drug discovery efforts. One such strategy that would complement current and future antibiotics would be a class of co-drugs that target the evolution of resistance and thereby extend the efficacy of specific classes of antibiotics...
September 20, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28892368/structure-based-design-and-synthesis-of-apramycin-paromomycin-analogues-importance-of-the-configuration-at-the-6-position-and-differences-between-the-6-amino-and-hydroxy-series
#16
Appi Reddy Mandhapati, Guanyu Yang, Takayuki Kato, Dimitri Shcherbakov, Sven N Hobbie, Andrea Vasella, Erik C Böttger, David Crich
The preparation of a series of four analogues of the aminoglycoside antibiotics neomycin and paromomycin is described in which ring I, involved in critical binding interactions with the ribosomal target, is replaced by an apramycin-like dioxabicyclo[4.4.0]octane system. The effect of this modification is to lock the hydroxymethyl side chain of the neomycin or paromomycin ring I, as part of the dioxabicyclooctane ring, into either the gauche-gauche or the gauche-trans conformation (respectively, axial or equatorial to the bicyclic system)...
October 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28886999/advances-in-macrocyclic-peptide-based-antibiotics
#17
Anatol Luther, Christian Bisang, Daniel Obrecht
Macrocyclic peptide-based natural products have provided powerful new antibiotic drugs, drug candidates, and scaffolds for medicinal chemists as a source of inspiration to design novel antibiotics. While most of those natural products are active mainly against Gram-positive pathogens, novel macrocyclic peptide-based compounds have recently been described, which exhibit potent and specific activity against some of the most problematic Gram-negative ESKAPE pathogens. This mini-review gives an up-date on recent developments...
August 19, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28861082/polyvinylpyrrolidone-capped-silver-nanoparticle-inhibits-infection-of-carbapenem-resistant-strain-of-acinetobacter-baumannii-in-the-human-pulmonary-epithelial-cell
#18
Vishvanath Tiwari, Monalisa Tiwari, Vandana Solanki
Acinetobacter baumannii, an opportunistic ESKAPE pathogen, causes respiratory and urinary tract infections. Its prevalence increases gradually in the clinical setup. Pathogenicity of Acinetobacter is significantly influenced by its ability to infect and survive in human pulmonary cells. Therefore, it is important to study the infection of A. baumannii in human pulmonary host cell (A-549), monitoring surface interacting and internalized bacteria. It was found that during infection of A. baumannii, about 40% bacteria adhered to A-549, whereas 20% got internalized inside pulmonary cell and induces threefold increase in the reactive oxygen species production...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28774148/synthesis-and-structural-characterization-of-silver-nanoparticles-stabilized-with-3-mercapto-1-propansulfonate-and-1-thioglucose-mixed-thiols-for-antibacterial-applications
#19
Francesco Porcaro, Laura Carlini, Andrea Ugolini, Daniela Visaggio, Paolo Visca, Ilaria Fratoddi, Iole Venditti, Carlo Meneghini, Laura Simonelli, Carlo Marini, Wojciech Olszewski, Nitya Ramanan, Igor Luisetto, Chiara Battocchio
The synthesis, characterization and assessment of the antibacterial properties of hydrophilic silver nanoparticles (AgNPs) were investigated with the aim to probe their suitability for innovative applications in the field of nanobiotechnology. First, silver nanoparticles were synthetized and functionalized with two capping agents, namely 3-mercapto-1-propansulfonate (3MPS) and 1-β-thio-d-glucose (TG). The investigation of the structural and electronic properties of the nano-systems was carried out by means of X-ray Photoelectron Spectroscopy (XPS) and X-ray Absorption Spectroscopy (XAS)...
December 20, 2016: Materials
https://www.readbyqxmd.com/read/28743946/identification-of-the-eskape-pathogens-by-mass-spectrometric-analysis-of-microbial-membrane-glycolipids
#20
Lisa M Leung, William E Fondrie, Yohei Doi, J Kristie Johnson, Dudley K Strickland, Robert K Ernst, David R Goodlett
Rapid diagnostics that enable identification of infectious agents improve patient outcomes, antimicrobial stewardship, and length of hospital stay. Current methods for pathogen detection in the clinical laboratory include biological culture, nucleic acid amplification, ribosomal protein characterization, and genome sequencing. Pathogen identification from single colonies by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis of high abundance proteins is gaining popularity in clinical laboratories...
July 25, 2017: Scientific Reports
keyword
keyword
47954
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"