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Mucosa-Associated Lymphoid Tissue Lymphoma

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https://www.readbyqxmd.com/read/28801448/long-term-results-of-a-phase-ii-study-of-rituximab-and-bendamustine-for-mucosa-associated-lymphoid-tissue-lymphoma
#1
Antonio Salar, Eva Domingo-Domenech, Carlos Panizo, Concepción Nicolás, Joan Bargay, Ana Muntañola, Miguel Canales, José Luis Bello, Juan Manuel Sancho, José Francisco Tomás, María José Rodríguez, Javier Peñalver, Carlos Grande, José Javier Sánchez-Blanco, Luis Palomera, Reyes Arranz, Eulogio Conde, Mar García, Juan Fernando García, Dolores Caballero, Carlos Montalbán
No abstract text is available yet for this article.
August 11, 2017: Blood
https://www.readbyqxmd.com/read/28765954/in%C3%A2-vitro-reconstitution-of-interactions-in-the-card9-signalosome
#2
Jin Hee Park, Jae Young Choi, Mir Faisal Mustafa, Hyun Ho Park
The caspase-associated recruitment domain (CARD)‑containing protein 9 (CARD9) signalosome is composed of CARD9, B‑cell CLL/lymphoma 10 (BCL10) and mucosa‑associated lymphoid tissue lymphoma translocation protein 1 (MALT1). The CARD9 signalosome has been reported to exert critical functions in the immunoreceptor tyrosine‑based activation motif‑coupled receptor‑mediated activation of myeloid cells, through nuclear factor‑κB pathways during innate immunity processes. During CARD9 signalosome assembly, BCL10 has been revealed to function as an adaptor protein and to interact with CARD9 via CARD‑CARD interactions; BCL10 also interacts with MALT1 via its C‑terminal Ser/Thr‑rich region and the first immunoglobulin domain of MALT1...
July 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28762251/h-pylori-management-in-asean-the-bangkok-consensus-report
#3
REVIEW
Varocha Mahachai, Ratha-Korn Vilaichone, Rapat Pittayanon, Jarin Rojborwonwitaya, Somchai Leelakusolvong, Monthira Maneerattanaporn, Peranart Chotivitayatarakorn, Sombat Treeprasertsuk, Chomsri Kositchaiwat, Pises Pisespongsa, Pisaln Mairiang, Aziz Rani, Alex Leow, Swe Mon Mya, Yi-Chia Lee, Sengdao Vannarath, Bouachanh Rasachak, Oung Chakravuth, Moe Myint Aung, Tiing-Leong Ang, Jose D Sollano, Duc Quach Trong, Inchaya Sansak, Olarn Wiwattanachang, Piyathida Harnsomburana, Ari Fahrial Syam, Yoshio Yamaoka, Kwong-Ming Fock, Khean-Lee Goh, Kentaro Sugano, David Graham
Helicobacter pylori (H. pylori) infection remains to be the major cause of important upper gastrointestinal diseases such as chronic gastritis, peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. H. pylori management in ASEAN: the Bangkok consensus report gathered key opinion leaders for the region to review and evaluate clinical aspects of H. pylori infection and to develop consensus statements, rationales and grades of recommendation for the management of H. pylori infection in clinical practice in ASEAN countries...
July 31, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28750630/conjunctival-lymphoma-during-pregnancy-a-case-report
#4
Sherine Jue Ong, Shih-Ming Jung, Hsin-Chiung Lin
BACKGROUND: To present a case of conjunctival lymphoma in a young woman complicated by pregnancy. CASE PRESENTATION: A 38-year-old previously healthy woman presented with a 2-year history of progressive right blepharoptosis. Giant papillomatous sessile masses were identified in the upper and lower fornix bilaterally and involved the tarsus of the right upper lid. The remaining ophthalmic examination was unremarkable. Histopathology and immunohistochemistry showed mucosa-associated lymphoid tissue (MALT) lymphoma with immunoglobulin kappa monotype...
July 27, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28749851/immunoglobulin-g4-igg4-positive-ocular-adnexal-mucosa-associated-lymphoid-tissue-lymphoma-and-idiopathic-orbital-inflammation
#5
Eun Jung Sohn, Hee Bae Ahn, Mee Sook Roh, Woo Jun Jung, Won Yeol Ryu, Yoon Hyung Kwon
PURPOSE: To report clinical and pathological characteristics of idiopathic orbital inflammation and ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma with immunoglobulin G4 (IgG4)-positive plasma cells. METHODS: A retrospective histopathological review and clinical case series. A total of 51 biopsy samples from January 2005 to December 2015 were used in this study, including 21 cases of biopsy-confirmed idiopathic orbital inflammation and 30 cases of biopsy-confirmed ocular adnexal MALT lymphoma...
July 26, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28730251/severe-upper-gastrointestinal-bleeding-determined-by-a-gastric-lymphoma-associated-with-helicobacter-pylori-positive-atrophic-gastritis
#6
Cosmin Vasile Obleagă, Cristin Constantin Vere, Ana Maria Pătraşcu, Emil Moraru, Antoanela Valentina Crafciuc, Maria Camelia Foarfă, Stelian ŞtefăniŢă Mogoantă, Costin Teodor Streba, Simona Bondari, Ştefan Paitici, Cecil Sorin Mirea, Ionică Daniel Vîlcea
The pathogenesis of gastric cancer regardless of histological structure is a classic example of gene-environment interaction, and an important epidemiological aspect was the recognized association with Helicobacter pylori infection. This paper describes a case of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in a young patient whose first sign of the disease was upper gastrointestinal bleeding and associated hemorrhagic shock. The patient is a 31-year-old man, diagnosed by endoscopy 10 years ago with H...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28720586/a-malt-lymphoma-prognostic-index-generated-from-the-dataset-of-the-ielsg-19-prospective-clinical-trial
#7
Catherine Thieblemont, Luciano Cascione, Annarita Conconi, Barbara Kiesewetter, Markus Raderer, Gianluca Gaidano, Maurizio Martelli, Daniele Laszlo, Bertrand Coiffier, Armando Lopez Guillermo, Valter Torri, Franco Cavalli, Peter W Johnson, Emanuele Zucca
There are no widely accepted prognostic indices for extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). This study aimed to develop and validate a specific prognostic tool to personalize and optimize lymphoma treatment of patients with MALT lymphoma. A prognostic index was built by Cox regression (stepwise selection) using data from 401 patients enrolled in the international randomized IELSG-19 trial (NCT 00210353). A validation set, including 633 patients, was obtained by merging three independent cohorts of MALT lymphoma patients...
July 18, 2017: Blood
https://www.readbyqxmd.com/read/28712656/treatments-for-ocular-adnexal-lymphoma-a-report-by-the-american-academy-of-ophthalmology
#8
Michael T Yen, Jurij R Bilyk, Edward J Wladis, Elizabeth A Bradley, Louise A Mawn
PURPOSE: To review the literature to determine the efficacy of available treatments for ocular adnexal lymphoma (OAL) and to evaluate the outcomes and complications of treatments in patients older than 13 years. METHODS: A literature search was conducted last in March 2017 in the PubMed and Cochrane Library databases for English-language original research investigations that evaluated treatment outcomes for OAL. The searches identified 307 unique citations, and 27 studies were selected according to the criteria outlined for this assessment...
July 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28710240/a-rare-case-of-gastric-mixed-adenoneuroendocrine-carcinoma-manec-with-gastric-helicobacter-pylori-negative-mucosa-associated-lymphoid-tissue-malt-lymphoma
#9
Babikir Kheiri, Mohammed Osman, Douglas Congdon, Ghassan Bachuwa
No abstract text is available yet for this article.
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28710097/germinal-centres-in-diagnostic-labial-gland-biopsies-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-are-not-predictive-for-parotid-malt-lymphoma-development
#10
Erlin A Haacke, Bert van der Vegt, Arjan Vissink, Fred K L Spijkervet, Hendrika Bootsma, Frans G M Kroese
OBJECTIVE: Patients with primary Sjögren's syndrome (pSS) have an increased risk of developing non-Hodgkin's lymphoma (NHL), particularly parotid gland mucosa-associated lymphoid tissue (MALT) lymphomas. Presence of germinal centres (GCs) in labial gland biopsies has been suggested as predictive factor for NHL. We assessed whether presence of GCs is increased in labial gland biopsies from patients with pSS who developed parotid MALT lymphoma, the dominant NHL-subtype in pSS, compared with patients with pSS who did not develop lymphoma...
July 14, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28695630/a-pilot-phase-ii-study-of-ofatumumab-monotherapy-for-extranodal-marginal-zone-b-cell-lymphoma-of-the-mucosa-associated-lymphoid-tissue-malt-lymphoma
#11
Barbara Kiesewetter, Ortrun Neuper, Marius E Mayerhoefer, Werner Dolak, Julius Lukas, Ingrid Simonitsch-Klupp, Markus Raderer
These are the final results of the Ofatumumab in MALT lymphoma study (O-MA 1), a pilot phase II trial evaluating the capacity and safety of ofatumumab to induce objective responses in patients with Helicobacter pylori eradication refractory or extragastric MALT lymphoma. Ofatumumab was given at 4 weekly doses (1000 mg) followed by 4 doses at 2-month intervals starting at week 8. According to protocol, a total of 16 patients were recruited (median age 69 years; range 38-85). Thirty one percent (5/16) of patients had primary gastric MALT lymphoma while the remaining 69% (11/16) presented with extragastric manifestations...
July 10, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28694862/primary-hepatic-marginal-zone-lymphoma-in-a-patient-with-chronic-hepatitis-c
#12
George S Gherlan, Razvan Stoia, Mihaly Enyedi, Camelia Dobrea, Petre I Calistru
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is a low-grade malignant lymphoma that appears frequently in the stomach, but other sites can also be involved: the intestinal tract, lungs, head, neck, skin, thyroid, breasts and liver. Recently, epidemiological evidences support the idea that there is an association between hepatitis C and B-cell non-Hodgkin lymphomas (that include MALT as a subtype). Primary non-Hodgkin lymphomas confi ned only to the liver are very rare (only 0...
September 2016: Mædica
https://www.readbyqxmd.com/read/28690277/preoperative-diagnostic-algorithm-of-primary-thyroid-lymphoma-using-ultrasound-aspiration-cytology-and-flow-cytometry
#13
Mitsuyoshi Hirokawa, Takumi Kudo, Hisashi Ota, Ayana Suzuki, Kaoru Kobayashi, Akira Miyauchi
The aims of this report were to clarify the diagnostic significance of ultrasound (US), fine needle aspiration cytology (FNAC), and flow cytometry for primary thyroid lymphoma, and to establish a preoperative diagnostic algorithm of primary thyroid lymphoma. We retrospectively examined US, FNAC, and flow cytometry in 43 patients with benign lymphoproliferative lesions and 32 patients with primary thyroid lymphoma, who underwent US, FNAC, and flow cytometry at Kuma Hospital between May 2012 and December 2015...
July 8, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28682481/significant-association-between-tnfaip3-inactivation-and-biased-immunoglobulin-heavy-chain-variable-region-4-34-usage-in-mucosa-associated-lymphoid-tissue-lymphoma
#14
Sarah Moody, Leire Escudero-Ibarz, Ming Wang, Alexandra Clipson, Eguzkine Ochoa Ruiz, Deborah Dunn-Walters, Xuemin Xue, Naiyan Zeng, Alistair Robson, Shih-Sung Chuang, Sergio Cogliatti, Hongxiang Liu, John Goodlad, Margaret Ashton-Key, Markus Raderer, Yingwen Bi, Ming-Qing Du
Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development critically depends on their cooperation. However, which of these different events concur and how they cooperate in MALT lymphomagenesis is totally unknown. To explore this, we investigated somatic mutations of 17 genes and immunoglobulin heavy chain variable region (IGHV) usage in 179 MALT lymphomas from various sites...
July 6, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28682047/upper-gastrointestinal-conditions-nonmalignant-conditions-of-the-stomach
#15
Ku-Lang Chang, David S Estores
Functional dyspepsia can be categorized into two syndromes: postprandial distress syndrome and epigastric pain syndrome. Helicobacter pyloriinfection is one of the most common chronic infections worldwide. Acute H pylori infection causes dyspepsia, and chronic infection can cause peptic ulcer disease. H pylori also is one of the causative agents in gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. The incidence of H pylori infection varies among different ethnic populations and geographic locations...
July 2017: FP Essentials
https://www.readbyqxmd.com/read/28668260/-amyopathic-dermatomyositis-dm-with-anti-mda5-antibodies-associated-with-bullous-pemphigoid-sj%C3%A3-gren-syndrome-and-gastric-malt-lymphoma
#16
B Garcia, F Dabouz, L Pascal, M Gillard, P Modiano
BACKGROUND: The inflammatory myopathies are a heterogeneous group of muscle diseases and comprise polymyositis, dermatomyositis (DM), myopathies associated with cancers, necrotising myositis and inclusion body myositis. DM occasionally exhibits few or no muscular signs: i.e. hypomyopathic/amyopathic DM. Anti-MDA5 dermatomyositis (DM) is a rare form of dermatomyositis that is frequently amyopathic; the prognosis is linked mainly to pulmonary involvement. PATIENTS AND METHODS: A 69-year-old woman treated for mucosa-associated lymphoid tissue (MALT) gastric lymphoma was referred for a bullous eruption...
June 28, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28655094/-a-retrospective-analysis-of-clinical-characteristics-and-prognostic-factors-for-124-cases-of-primary-gastric-lymphomas
#17
Y He, L Wang, H Y Zhu, J H Liang, W Wu, J Z Wu, Y Xia, L Cao, L Fan, J Y Li, W Xu
Objective: To analyze the clinical characteristics, treatment and prognosis of primary gastric lymphomas (PGL). Methods: A retrospective study was conducted in 124 cases of PGL from July 2009 to January 2016 in our hospital, and the clinical records, pathological and immunohistochemical features were analyzed. The relationship between different factors at diagnosis and prognosis were studied. Results: 124 cases of PGL included 93 diffuse large B cell lymphoma (DLBCL) patients, 25 mucosa associated lymphoid tissue (MALT) lymphoma cases, 1 mantle cell lymphoma, 4 peripheral T-cell lymphoma-not otherwise specified, and 1 extra-nodal NK/T-cell lymphoma-nasal type...
June 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28652666/synchronous-triple-occurrence-of-malt-lymphoma-schwannoma-and-adenocarcinoma-of-the-stomach
#18
Kyeong W Choi, Mee Joo, Han S Kim, Woo Y Lee
We present a case of a 56-year-old man with 3 synchronous gastric tumors. The patient presented with melena, and 3 gastric abnormalities were detected on gastroduodenoscopic examination, including a small ulcerative lesion in the gastric antrum, a submucosal mass in the gastric body, and severe erosion in the fundus. Histological examination of biopsy samples yielded respective diagnoses of gastric adenocarcinoma, gastritis, and mucosa-associated lymphoid tissue (MALT) lymphoma. The patient first received medication to eradicate any underlying Helicobacter pylori infection, which might have been a cause of the MALT lymphoma...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28652651/molecular-mimicry-in-helicobacter-pylori-infections
#19
REVIEW
Magdalena Chmiela, Weronika Gonciarz
Gram-negative bacteria Helicobacter pylori (H. pylori) colonize gastric mucosa in humans and increase the risk of serious diseases such as gastric and duodenal ulcers, stomach cancers and mucosa associated lymphoid tissue lymphoma. The role of H. pylori infection in the pathogenesis of several extragastric diseases has been suggested including immune thrombocytopenic purpura, iron deficiency anemia, vitamin D deficiency, cardiovascular diseases, diabetes mellitus and dermatological disorders. Also neurological diseases and even lung cancer have attracted researchers concern...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28644136/chemotherapy-alone-is-an-alternative-treatment-in-treating-localized-primary-ocular-adnexal-lymphomas
#20
Wei-Li Ma, Ming Yao, Shu-Lang Liao, Jih-Luh Tang, Yao-Ching Wang, Sung-Hsin Kuo, Ann-Lii Cheng
This study investigated the treatment efficacy and long-term adverse effects of various treatment modalities for primary ocular adnexal lymphomas (POALs). We retrospectively reviewed 107 patients who received first-line chemotherapy, radiotherapy, and other treatment modalities from 1990 to 2015. Nighty-three (87%) patients were diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma, with the orbit being the most common site (49 patients, 46%). Among 91 patients with stage I-IIE1 disease, 26 underwent chemotherapy, 34 underwent radiotherapy, and 31 received other treatment modalities...
June 15, 2017: Oncotarget
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