Kenji Hosoi, Yoshikazu Ohtsuka, Tohru Fujii, Takahiro Kudo, Nobuaki Matsunaga, Takeshi Tomomasa, Hitoshi Tajiri, Reiko Kunisaki, Takashi Ishige, Hiroyuki Yamada, Katsuhiro Arai, Atsushi Yoden, Kosuke Ushijima, Tomoki Aomatsu, Satoru Nagata, Keiichi Uchida, Kazuo Takeuchi, Toshiaki Shimizu
BACKGROUND AND AIM: Childhood-onset inflammatory bowel disease (IBD) is characterized by extensive intestinal involvement and rapid early progression. Infliximab (IFX), cyclosporin (CYA), and tacrolimus (FK506) are increasingly used to treat pediatric IBD; however, their long-term effects and adverse events have not been properly investigated in pediatric patients. The aim of this study was to characterize the effects of these biologics and immunomodulators on pediatric IBD patients in Japan...
January 2017: Journal of Gastroenterology and Hepatology