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https://www.readbyqxmd.com/read/28346363/rapid-and-low-cost-crp-measurement-by-integrating-a-paper-based-microfluidic-immunoassay-with-smartphone-crp-chip
#1
Meili Dong, Jiandong Wu, Zimin Ma, Hagit Peretz-Soroka, Michael Zhang, Paul Komenda, Navdeep Tangri, Yong Liu, Claudio Rigatto, Francis Lin
Traditional diagnostic tests for chronic diseases are expensive and require a specialized laboratory, therefore limiting their use for point-of-care (PoC) testing. To address this gap, we developed a method for rapid and low-cost C-reactive protein (CRP) detection from blood by integrating a paper-based microfluidic immunoassay with a smartphone (CRP-Chip). We chose CRP for this initial development because it is a strong biomarker of prognosis in chronic heart and kidney disease. The microfluidic immunoassay is realized by lateral flow and gold nanoparticle-based colorimetric detection of the target protein...
March 26, 2017: Sensors
https://www.readbyqxmd.com/read/28346350/fast-and-selective-plasmonic-serotonin-detection-with-aptamer-gold-nanoparticle-conjugates
#2
Jorge L Chávez, Joshua A Hagen, Nancy Kelley-Loughnane
Neurotransmitters detection is critical to understanding communication between the brain and peripheral tissue. Serotonin is a key neurotransmitter linked to a number of conditions, but a full understanding of its role in disease is still lacking. The development of fast and selective serotonin detection platforms will provide researchers with tools to monitor serotonin in individuals before and after treatment for the condition of interest. Aptamer-gold nanoparticles conjugates that responded colorimetrically to serotonin with minimal response to its metabolite and other neurotransmitters were designed by simply adsorbing the DNA on the surface of AuNPs...
March 25, 2017: Sensors
https://www.readbyqxmd.com/read/28345903/molecular-imprinting-on-inorganic-nanozymes-for-hundred-fold-enzyme-specificity
#3
Zijie Zhang, Xiaohan Zhang, Biwu Liu, Juewen Liu
Enzyme-mimicking nanomaterials (nanozymes) are more cost-effective and robust than protein enzymes, but they lack specificity. Herein, molecularly imprinted polymers were grown on Fe3O4 nanozymes with peroxidase-like activity to create substrate binding pockets. Electron microscopy confirmed a shell of nanogel. By imprinting with an adsorbed substrate, moderate specificity was achieved with neutral monomers. Further introducing charged monomers led to nearly 100-fold specificity for the imprinted substrate over the non-imprinted compared to that of bare Fe3O4...
March 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28345887/from-detection-to-resection-photoacoustic-tomography-and-surgery-guidance-with-au-liposome-icg-nanoparticles-in-liver-cancer
#4
Tianpei Guan, Wenting Shang, Hui Li, Xin Yang, Chihua Fang, Jie Tian, Kun Wang
Conventional imaging methods encounter challenges in diagnosing liver cancer that is less than 10 mm and/or without typical hypervascular features. With deep penetration and high spatial resolution imaging capability, the emerging photoacoustic tomography may offer better diagnostic efficacy for non-invasive liver cancer detection. Moreover, near-infrared fluorescence imaging guided hepatectomy was proven to be able to identify nodules at millimeter level. Thus, suitable photoacoustic and fluorescence dual-modality imaging probe may benefit patients in early diagnosis and complete resection...
March 27, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28345718/probing-the-binding-affinity-of-plasma-proteins-adsorbed-on-au-nanoparticles
#5
Xiaoning Zhang, Junting Zhang, Fan Zhang, Shaoning Yu
Nanoparticle (NP) surfaces are modified immediately by the adsorption of proteins when exposed to human blood, leading to the formation of a protein corona. The adsorption of serum proteins is the key process for exploring the bioapplication and biosafety of NPs. In this study, NP-protein binding affinity (Ka) was investigated. Some serum proteins, such as human serum albumin (HSA), trypsin (TRP), hemoglobin (Hb), myoglobin (MB), immunoglobulin G (IgG), carbonic anhydrase (CA), fibrinogen (FIB), chymotrypsin and r-globulin, were used with gold nanoparticles (AuNPs) to address binding affinity according to isothermal titration calorimetry (ITC) combined with dynamic light scattering (DLS) and fluorescence quenching...
March 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28345581/potential-of-biosynthesized-silver-nanoparticles-using-stenotrophomonas-sp-bhu-s7-mtcc-5978-for-management-of-soil-borne-and-foliar-phytopathogens
#6
Sandhya Mishra, Braj Raj Singh, Alim H Naqvi, H B Singh
Stenotrophomonas sp. is emerging as a popular microbe of global concern with various potential ecological roles. Biosynthesis of gold and silver nanoparticles (AgNPs) using this bacterial strain has shown promising applications in life sciences. However, there is no report on efficient agricultural applications of biosynthesized AgNPs using Stenotrophomonas sp. In this regard, successful biosynthesis of AgNPs using Stenotrophomonas sp. BHU-S7 (MTCC 5978) was monitored by Uv-visible spectrum showing surface plasmon resonance (SPR) peak at 440 nm...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28345351/shape-memory-characteristics-of-o157-antigenic-cavities-generated-on-nanocomposites-consisting-of-copolymer-encapsulated-gold-nanoparticles
#7
Takamasa Kinoshita, Dung Quang Nguyen, Dung Quynh Le, Kengo Ishiki, Hiroshi Shiigi, Tsutomu Nagaoka
Nanometer-sized composite particles, which consisted of gold nanoparticles encapsulated by an N-isopropylacrylamide copolymer, were successfully synthesized using a one-step process. Shape complementary cavities of the O157-antigen were formed on the composite utilizing temperature-dependent affinity changes of the copolymer. The composite bound to enterohemorrhagic Escherichia coli (E. coli) O157 at 298 K and enhanced light-scattering intensity of the cell due to the optical properties of the gold nanoparticles...
March 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28344779/accuracy-of-the-detection-of-binding-events-using-3d-single-particle-tracking
#8
Sara Carozza, Jamie Culkin, John van Noort
BACKGROUND: Nanoparticles can be used as markers to track the position of biomolecules, such as single proteins, inside living cells. The activity of a protein can sometimes be inferred from changes in the mobility of the attached particle. Mean Square Displacement analysis is the most common method to obtain mobility information from trajectories of tracked particles, such as the diffusion coefficient D. However, the precision of D sets a limit to discriminate changes in mobility caused by biological events from changes that reflect the stochasticity inherent to diffusion...
2017: BMC Biophysics
https://www.readbyqxmd.com/read/28342314/electrochemical-dna-sandwich-biosensor-based-on-enzyme-amplified-microrna-21-detection-and-gold-nanoparticles
#9
Jihane Mandli, Hasna Mohammadi, Aziz Amine
In this work, a novel electrochemical biosensor for miRNA-21 determination, involving a sandwich hybridization assay onto gold nanoparticles modified pencil graphite electrode (PGE) and enzyme signal amplification was reported. The thiol terminated capture probe 1 (SH-P1) was immobilized on the electrode through AuS interaction. In the presence of target miRNA-21, SH-P1 hybridized with the first part of the target, however, the second part hybridizes with a biotinylated probe P2 (B-P2). Then, a streptavidin-conjugated alkaline phosphatase was immobilized by a specific binding of avidin-B-P2...
March 14, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28342023/biogenic-synthesis-of-marsilea-quadrifolia-gold-nanoparticles-a-study-of-improved-glucose-utilization-efficiency-on-3t3-l1-adipocytes
#10
Anindita Chowdhury, Selvaraj Kunjiappan, Chiranjib Bhattacharjee, Balasubramanian Somasundaram, Theivendren Panneerselvam
This study aims mainly to provide an insight and understanding of the effect of glucose utilization efficiency of biogenic gold nanoparticles (GNPs) synthesized through the mediation of Marsilea quadrifolia (M. quadrifolia) methanol extract on 3T3-L1 adipocytes. The biosynthesized GNPs were characterized by UV visible spectrophotometry and FTIR. Simultaneously, the nature, stability, and morphological characteristics were analyzed by XRD, TG-DTA, SEM-EDS, HRTEM, and SAED. The results of characterization studies were used to assess the properties of GNPs...
March 24, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28341392/novel-synthesis-of-gold-nanoparticles-using-artemisia-vulgaris-l-leaf-extract-and-their-efficacy-of-larvicidal-activity-against-dengue-fever-vector-aedes-aegypti-l
#11
B Sundararajan, B D Ranjitha Kumari
The Aedes aegypti L. mosquito transmits dengue and yellow fever, which cause millions of death every year. Dengue is a mosquito-borne viral disease that has rapidly spread worldwide particularly in countries with tropical and subtropical climates areas. The present study denotes a simple and eco-friendly biosynthesis of gold nanoparticles using Artemisia vulgaris L. leaf extract as reducing agent. The synthesized gold nanoparticles were characterized by UV-Visible Spectroscopy, X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR), Dynamic Light Scattering (DLS), Zeta Potential (ZP), Transmission Electron Microscopy (TEM) and Energy Dispersive X-ray Spectroscopy (EDX)...
March 18, 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28340777/taylor-dispersion-analysis-resonant-mass-measurement-and-bioactivity-of-pepsin-coated-gold-nanoparticles
#12
Markus Höldrich, Siyao Liu, Markus Epe, Michael Lämmerhofer
Immobilized enzyme reactors based on nanoparticulate carriers are becoming increasingly popular. A toolbox of methods is usually utilized for their characterization in order to be capable of assessing their suitability for the intended purpose. In this work, as a model system pepsin was conjugated to gold nanoparticles (GNPs) by a straightforward adsorptive immobilization process. The success of the immobilization procedure was monitored by Vis spectroscopy via shifts of the localized surface plasmon resonance (LSPR) band, size characterization by dynamic light scattering (DLS), and ζ-potential determinations by electrophoretic light scattering...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340765/detection-of-trace-levels-of-organophosphate-pesticides-using-an-electronic-tongue-based-on-graphene-hybrid-nanocomposites
#13
Murilo H M Facure, Luiza A Mercante, Luiz H C Mattoso, Daniel S Correa
Organophosphate (OP) compounds impose significant strains on public health, environmental/food safety and homeland security, once they have been widely used as pesticides and insecticides and also display potential to be employed as chemical warfare agents by terrorists. In this context, the development of sensitive and reliable chemical sensors that would allow in-situ measurements of such contaminants is highly pursued. Here we report on a free-enzyme impedimetric electronic tongue (e-tongue) used in the analysis of organophosphate pesticides comprising four sensing units based on graphene hybrid nanocomposites...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340752/highly-sensitive-ratiometric-quantification-of-cyanide-in-water-with-gold-nanoparticles-via-resonance-rayleigh-scattering
#14
Yulán Hernández, Yves Coello, Raluca M Fratila, Jesús M de la Fuente, Troy A Lionberger
A highly sensitive and selective ratiometric sensor for the quantification of cyanide (CN(-)) in aqueous samples has been developed using spherical gold nanoparticles (AuNPs) stabilized by polysorbate 40 (PS-40). Three different AuNP sizes (14, 40 and 80nm mean diameters) were used to evaluate the response of the sensor using both colorimetric and Resonance Rayleigh Scattering (RRS) detection schemes. The best results were obtained for the sensor using 40nm AuNPs, for which the limits of detection (LODs) were found to be 100nmolL(-1) in a benchtop instrument and 500nmolL(-1) by the naked eye, values well below the maximum acceptable level for drinking water (1...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340746/a-novel-sensitive-amperometric-choline-biosensor-based-on-multiwalled-carbon-nanotubes-and-gold-nanoparticles
#15
Hend Samy Magar, Mariana Emilia Ghica, Mohammed Nooredeen Abbas, Christopher M A Brett
A novel amperometric biosensor for choline determination has been developed, exploiting the electrocatalytic properties of multiwalled carbon nanotubes (MWCNT) and gold nanoparticles (GNP). Chitosan (Chit), a natural biocompatible polymer, was used to disperse CNT, then Chit-MWCNT was dropped on the surface of a glassy carbon electrode (GCE), followed by GNP; finally, choline oxidase (ChOx) was immobilized by glutaraldehyde crosslinking. The ChOx/(GNP)4/MWCNT/GCE exhibited linear response to choline from 3 to 120µM, the sensitivity was 204µAcm(-2)mM(-1) and the detection limit was 0...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340710/selective-colorimetric-analysis-of-spermine-based-on-the-cross-linking-aggregation-of-gold-nanoparticles-chain-assembly
#16
Jian Wang, Zhu Lian Wu, Hong Zhi Zhang, Yuan Fang Li, Cheng Zhi Huang
A selective colorimetric assay for spermine was proposed in this work. In a weak alkaline medium, the conformational structure of double-stranded calf thymus DNA (ctDNA) was loosened to install gold nanoparticles (AuNPs) into chains. While, the chain assembly of AuNPs could form cross-linking aggregates when spermine was present, which was attributed to the electrostatic interaction between the positive change of spermine and negative change both of AuNPs and ctDNA, as well as the groove binding between ctDNA and spermine...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340706/layer-by-layer-self-assembly-of-gold-nanoparticles-thiols-%C3%AE-cyclodextrin-coating-as-the-stationary-phase-for-enhanced-chiral-differentiation-in-open-tubular-capillary-electrochromatography
#17
Lin-Lin Fang, Ping Wang, Xiao-Li Wen, Xin Guo, Lin-da Luo, Jia Yu, Xing-Jie Guo
The popularity of capillary electrochromatography (CEC) has led to an increasing number of studies on the development and evaluation of enantioselective CEC systems. Herein, a novel, simple, and economical method for the preparation of chiral stationary phases for enantioselective open tubular capillary electrochromatography (OTCEC) was reported for the first time. This novel capillary column was fabricated through layer-by-layer self-assembly of GNPs on a 3-mercaptopropyl-trimethoxysilane (MPTMS)-modified fused-silica capillary and subsequent surface functionalization of the GNPs through self-assembly of thiols β-cyclodextrin (SH-β-CD)...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28338323/shape-dependent-radiosensitization-effect-of-gold-nanostructures-in-cancer-radiotherapy-comparison-of-gold-nanoparticles-nanospikes-and-nanorods
#18
Ningning Ma, Fu-Gen Wu, Xiaodong Zhang, Yao-Wen Jiang, Hao-Ran Jia, Hong-Yin Wang, Yan-Hong Li, Peidang Liu, Ning Gu, Zhan Chen
The shape effect of gold (Au) nanomaterials on the efficiency of cancer radiotherapy has not been fully elucidated. To address this issue, Au nanomaterials with different shapes but similar average size (~50 nm) including gold nanoparticles (GNPs), gold nanospikes (GNSs), and gold nanorods (GNRs) were synthesized and functionalized with poly(ethylene glycol) (PEG) molecules. Although all these Au nanostructures were coated with the same PEG molecules, their cellular uptake behavior differed significantly. The GNPs showed the highest cellular responses compared to the GNSs and the GNRs (based on the same gold mass) after incubation with KB cancer cells for 24 h...
March 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28338146/a-gold-nanoparticle-mediated-rapid-in-vitro-assay-of-anti-aggregation-reagents-for-amyloid-%C3%AE-and-its-validation
#19
Hye Young Kim, Donghee Lee, Kwon-Yul Ryu, Inhee Choi
Herein, we report a rapid in vitro assay of amyloid β anti-aggregation reagents using gold nanoparticles as nucleation cores and optical reporters. Based on the colorimetric responses observed with the naked eye, effective anti-aggregation reagents were rapidly (<15 min) distinguished. For these reagents, conventional methods showed fewer amyloid β aggregates and an increased viability of neuroblastoma cells after treatment. We envision that our proposed method will facilitate the discovery of efficient drug components for the treatment of Alzheimer's disease...
March 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28337198/role-of-metallic-nanoparticles-in-vaccinology-implications-for-infectious-disease-vaccine-development
#20
REVIEW
Lázaro Moreira Marques Neto, André Kipnis, Ana Paula Junqueira-Kipnis
Subunit vaccines are safer but less immunogenic than live-attenuated vaccines or whole cell inactivated vaccines. Adjuvants are used to enhance and modulate antigen (Ag) immunogenicity, aiming to induce a protective and long-lasting immune response. Several molecules and formulations have been studied for their adjuvanticity, but only seven have been approved to formulate human vaccines. Metallic nanoparticles (MeNPs), particularly those containing gold and iron oxides, are widely used in medicine for diagnosis and therapy and have been used as carriers for drugs and vaccines...
2017: Frontiers in Immunology
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