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https://www.readbyqxmd.com/read/29353430/multiplex-highly-sensitive-immunochromatographic-assay-based-on-the-use-of-nonprocessed-antisera
#1
Nadezhda A Byzova, Alexandr E Urusov, Anatoly V Zherdev, Boris B Dzantiev
The format of an immunochromatographic multiassay is first proposed with native antisera and a universal conjugate of antispecies antibodies with gold nanoparticles. This format allows (1) the exclusion of purification and conjugation stages for specific antibodies and (2) significant reduction of the concentration of specific antibodies in the system. The independent use of specific antibodies and a conjugated marker provided a low detection limit and high signal intensity. The proposed format was implemented for the simultaneous detection of two herbicides...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29352869/positively-charged-gold-nanoparticles-capped-with-folate-quaternary-chitosan-synthesis-cytotoxicity-and-uptake-by-cancer-cells
#2
Hui-Ju Yen, Yen-An Young, Tsung-Neng Tsai, Kuang-Ming Cheng, Xin-An Chen, Ying-Chuan Chen, Cheng-Cheung Chen, Jenn-Jong Young, Po-da Hong
In this study, we synthesized various quaternary chitosan derivatives and used them to stabilize gold nanoparticles (AuNPs). These chitosan derivatives comprised N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride (HTCC), folate-HTCC, galactosyl-HTCC, and their fluorescein isothiocyanate-conjugated derivatives. Various positively surface-charged AuNPs were prepared under alkaline conditions using glucose as a reducing agent in the presence of the HTCC derivatives (HTCCs). The effects of the concentration of NaOH, glucose, and HTCCs on the particles size, zeta potential, and stability were studied in detail...
March 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29348833/gold-nanoparticles-as-a-potent-radiosensitizer-in-neutron-therapy
#3
Eun Ho Kim, Mi-Sook Kim, Hyo Sook Song, Seung Hoon Yoo, Sei Sai, Kwangzoo Chung, Jiwon Sung, Youn Kyoung Jeong, YunHui Jo, Myonggeun Yoon
The purpose of this study was to investigate the potential of gold nanoparticles as radiosensitizer for use in neutron therapy against hepatocellular carcinoma. The hepatocellular carcinoma cells lines Huh7 and HepG2 were irradiated with γ and neutron radiation in the presence or absence of gold nanoparticles. Effects were evaluated by transmission electron microscopy, cell survival, cell cycle, DNA damage, migration, and invasiveness. Gold nanoparticles significantly enhanced the radiosensitivity of Huh7 and HepG2 cells to γ-rays by 1...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348364/building-superlattices-from-individual-nanoparticles-via-template-confined-dna-mediated-assembly
#4
Qing-Yuan Lin, Jarad A Mason, Zhongyang Li, Wenjie Zhou, Matthew N O'Brien, Keith A Brown, Matthew R Jones, Serkan Butun, Byeongdu Lee, Vinayak P Dravid, Koray Aydin, Chad A Mirkin
DNA programmable assembly has been combined with top-down lithography to construct superlattices of discrete, reconfigurable nanoparticle architectures on a gold surface over large areas. Specifically, the assembly of individual colloidal plasmonic nanoparticles with different shapes and sizes is controlled by oligonucleotides containing "locked" nucleic acids and confined environments provided by polymer pores to yield oriented architectures that feature tunable arrangements and independently controllable distances at both nanometer and micrometer length scales...
January 18, 2018: Science
https://www.readbyqxmd.com/read/29346397/dose-enhancement-effects-of-gold-nanoparticles-specifically-targeting-rna-in-breast-cancer-cells
#5
Georg Hildenbrand, Philipp Metzler, Götz Pilarczyk, Vladimir Bobu, Wilhelm Kriz, Hiltraud Hosser, Jens Fleckenstein, Matthias Krufczik, Felix Bestvater, Frederik Wenz, Michael Hausmann
Localization microscopy has shown to be capable of systematic investigations on the arrangement and counting of cellular uptake of gold nanoparticles (GNP) with nanometer resolution. In this article, we show that the application of specially modified RNA targeting gold nanoparticles ("SmartFlares") can result in ring like shaped GNP arrangements around the cell nucleus. Transmission electron microscopy revealed GNP accumulation in vicinity to the intracellular membrane structures including them of the endoplasmatic reticulum...
2018: PloS One
https://www.readbyqxmd.com/read/29346076/ultrasensitive-electrochemical-immuno-sensing-platform-based-on-gold-nanoparticles-triggering-chlorpyrifos-detection-in-fruits-and-vegetables
#6
Anita Talan, Annu Mishra, Sergei A Eremin, Jagriti Narang, Ashok Kumar, Sonu Gandhi
Chlorpyrifos (chl) is an organophosphate pesticide extensively used in agriculture and highly toxic for human health. Fluorine doped tin-oxide (FTO) based electrochemical nanosensor was developed for chlorpyrifos detection with gold nanoparticles (AuNPs) and anti-chlorpyrifos antibodies (chl-Ab). AuNPs provides high electrical conductivity and specific resistivity, thus increases the sensitivity of immunoassay. High electrical conductivity of AuNPs reveals that it promotes the redox reaction for better cyclic voltammetry...
January 9, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29346037/development-of-an-ultrasensitive-pcr-assay-for-polycyclic-musk-determination-in-fish
#7
Xiaohan Zhang, Huisheng Zhuang
Polycyclic musks (PCMs) in the aquatic environment and organisms have become an emerging environmental issue because of their potential risk. The most used method for polycyclic musk determination is gas chromatography-mass spectrometry (GC-MS) with different sample extractions, which are somewhat expensive to operate, complex and laborious. In this study, a novel and ultrasensitive real-time polymerase chain reaction (PCR) assay with multiple signal amplification of carboxylic-DNA by gold nanoparticle-polyamidoamine conjugation (Au-PAMAM) was developed for determining polycyclic musks in fish...
January 18, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29345701/effects-of-particle-size-and-annealing-on-plasmon-induced-charge-separation-at-self-assembled-gold-nanoparticle-arrays
#8
Kun-Che Kao, Hiroyasu Nishi, Tetsu Tatsuma
Two-dimensional periodic Au nanoparticle arrays were constructed on TiO2 thin films by a micelle lithography method and seed-mediated photoelectrochemical growth. Their adjustable interparticle distance allows investigation of a particle size effect on plasmon-induced charge separation (PICS) efficiencies without interference from particle aggregation or plasmon coupling. External or internal PICS efficiencies were found to increase and decrease, respectively, with an increase in particle diameter from 25 to 38 nm...
January 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29345568/surface-bioengineered-gold-nanoparticles-for-biomedical-applications
#9
Zhicong Miao, Zilin Gao, Ruoxia Chen, Xiaoqing Yu, Zhiqiang Su, Gang Wei
The conjugation of gold nanoparticles (AuNPs) with biomolecules could create many outstanding biofunctions for the surface-functionalized nanoparticles and extend their biomedical applications. In this review, we summarize the recent advances in the surface bioengineering of AuNPs with biomolecules, such as DNA, proteins, peptides, and biopolymers, in which the details on the structure, functions, and properties of surface-bioengineered AuNPs are discussed. In addition, the surface-biofunctionalization of AuNPs for biomedical applications like biosensing, bioimaging, drug delivery, and tissue engineering are introduced...
January 16, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29345211/developing-single-entity-theranostic-drug-based-fluorescent-nanoclusters-with-augmented-cytotoxicity
#10
Bandhan Chatterjee, Asif Raza, Siddhartha Sankar Ghosh
AIM: To develop methotrexate (MTX) templated luminescent gold nanoclusters (NCs) as a single unit nanotheranostic for cancer therapy and to assess its potential as an alternative to the parent drug, for drug delivery vehicles (DDVs). METHODS: Theranostics were synthesized and extensively characterized. The stability of the theranostic and its bioimaging aptitude were evaluated. The antiproliferative propensity of the theranostic was gauged with cell viability assays and was supplemented with cytometry-based assays...
January 18, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29344800/platycodon-saponins-from-platycodi-radix-platycodon-grandiflorum-for-the-green-synthesis-of-gold-and-silver-nanoparticles
#11
Yoonho Choi, Sehyeon Kang, Song-Hyun Cha, Hyun-Seok Kim, Kwangho Song, You Jeong Lee, Kyeongsoon Kim, Yeong Shik Kim, Seonho Cho, Youmie Park
A green synthesis of gold and silver nanoparticles is described in the present report using platycodon saponins from Platycodi Radix (Platycodon grandiflorum) as reducing agents. Platycodin D (PD), a major triterpenoidal platycodon saponin, was enriched by an enzymatic transformation of an aqueous extract of Platycodi Radix. This PD-enriched fraction was utilized for processing reduction reactions of gold and silver salts to synthesize gold nanoparticles (PD-AuNPs) and silver nanoparticles (PD-AgNPs), respectively...
January 17, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29343696/decoupled-in-plane-dipole-resonance-modulated-colorimetric-assay-based-optical-ruler-for-ultra-trace-gold-au-detection
#12
Ajoy Mandal, Maireyee Bhattacharya, Denis V Kuznetsov, Tapas Ghosh, Sudeshna Das Chakraborty, Biswarup Satpati, Vsevolod Mazov, Dulal Senapati
Decoupling of different plasmon resonance modes (in-plane, and out-of-plane dipole and quadrupole resonances) by tuning nanoparticle's size and shape offers a new field of plasmonics as colorimetric assay-based optical-ruler for ultra-trace sensing. Driven by its low cost, easy to perform and efficient way to measure trace level (up to 30 ppt in presence of common mining elements in natural gold ore) abundance, this study develops a highly selective and ultrasensitive turn-on colorimetric sensor to detect gold-ion from environmental samples...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29341915/influence-of-ligands-property-and-particle-size-of-gold-nanoparticles-on-the-protein-adsorption-and-corresponding-targeting-ability
#13
Wei Xiao, Jingyuan Xiong, Shuang Zhang, Yang Xiong, Huajin Zhang, Huile Gao
Nanoparticulated vesicles were widely used for carriers of drugs and imaging probes. To improve the targeting delivery efficiency of these vesicles, ligands were often functionalized onto their surfaces. However, the interaction between vesicles and plasma proteins may cover the ligands and hinder the targeting delivery. It is important to address the potential influence of ligands modification on plasma protein adsorption and the following targeting delivery. In this study, two common used ligands were chosen as the model: transferrin and RGD peptide...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341615/merely-measuring-the-uv-visible-spectrum-of-gold-nanoparticles-can-change-their-charge-state
#14
Jose Navarrete, Chris Siefe, Samuel Alcantar, Michael Belt, Galen D Stucky, Martin Moskovits
Metallic nanostructures exhibit a strong plasmon resonance at a wavelength whose value is sensitive to the charge density in the nanostructure, its size, shape, interparticle coupling and the dielectric properties of its surrounding medium. Here we use UV-Visible transmission and reflectance spectroscopy to track the shifts of the plasmon resonance in an array of gold nanoparticles buried under metal-oxide layers of varying thickness produced using atomic layer deposition (ALD), then coated with bulk layers of one of three metals: aluminum, silver, and gold...
January 17, 2018: Nano Letters
https://www.readbyqxmd.com/read/29341583/tumor-catalytic-photothermal-therapy-with-yolk-shell-gold-carbon-nanozymes
#15
Lei Fan, Xiangdong Xu, Chunhua Zhu, Jie Han, Lizeng Gao, Juqun Xi, Rong Guo
Nanozymes, as a new generation of artificial enzymes, offer great opportunities in biomedical engineering and disease treatment. Synergizing the multiple intrinsic functions of nanozymes can improve their performance in biological systems. Here, we report a novel nanozyme with yolk-shell structure fabricated by combining a single gold nanoparticle core with a porous hollow carbon shell nanospheres (Au@HCNs). Au@HCNs exhibited enzyme-like activities similar to horseradish peroxidase and oxidase under an acidic environment, showing the ability of ROS generation...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29341418/hand-held-clinical-dual-mode-ultrasound-photoacoustic-imaging-of-rat-urinary-bladder-and-its-applications
#16
Kathyayini Sivasubramanian, Vijitha Periyasamy, Rhonnie Austria Dienzo, Manojit Pramanik
Urinary bladder imaging is critical to diagnose urinary tract disorders, and bladder cancer. There is a great need for safe, non-invasive, and sensitive imaging technique which enables bladder imaging. Photoacoustic imaging is a rapidly growing imaging technique for various biological applications. It can be combined with clinical ultrasound imaging system for hand-held, dual modal ultrasound-photoacoustic real-time imaging. Structural (bladder wall) and functional (accretion of nanoparticles) bladder imaging is shown here with combined ultrasound and photoacoustic imaging in rats...
January 17, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29339567/erythrocyte-membrane-coated-gold-nanocages-for-targeted-photothermal-and-chemical-cancer-therapy
#17
Dao-Ming Zhu, Wei Xie, Yu-Sha Xiao, Meng Suo, Ming-Hui Zan, Qing-Quan Liao, Xue-Jia Hu, Li-Ben Chen, Bei Chen, Wen-Tao Wu, Li-Wei Ji, Hui-Ming Huang, Shi-Shang Guo, Xing-Zhong Zhao, Quan-Yan Liu, Wei Liu
Recently, red blood cell (RBC) membrane-coated nanoparticles have attracted much attention because of their excellent immune escapability; meanwhile, gold nanocages (AuNs) have been extensively used for cancer therapy due to their photothermal effect and drug delivery capability. The combination of the RBC membrane coating and AuNs may provide an effective approach for targeted cancer therapy. However, few reports have shown the utilization of combining these two technologies. Here, we design erythrocyte membrane-coated gold nanocages for targeted photothermal and chemical cancer therapy...
January 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29338269/the-reactivity-toward-ag-a-general-strategy-to-generate-a-new-emissive-center-from-the-nir-emitting-gold-nanoparticles
#18
Yaping Wang, Lulu Liu, Lingshan Gong, Ying Chen, Jinbin Liu
We report a facile strategy for the transformation of the single NIR-emitting AuNPs to dual-NIR-emitting bimetallic Ag@AuNPs based on the robust reactivity toward Ag(I) ions under mild conditions. The reactivities toward Ag(I) ions were discovered significantly different between the visible- and NIR-emitting glutathione(GSH)-coated AuNPs: the high GSH surface coverage on the 610 nm-emitting AuNPs resulted in an reversible interaction due to enough surface steric hindrance to resist Ag(I) ions from interaction with the Au(0) core, whereas the low GSH surface coverage on the 810 nm-emitting AuNPs led to both the anti-galvanic reaction and Ag(I)-carboxylate shell formation on surface of the AuNPs, which were responsible for the formation of a new emissive center at 705 nm...
January 17, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29337315/correction-one-step-coelectrodeposition-assisted-layer-by-layer-assembly-of-gold-nanoparticles-and-reduced-graphene-oxide-and-its-self-healing-three-dimensional-nanohybrid-for-an-ultrasensitive-dna-sensor
#19
Kumarasamy Jayakumar, María Belén Camarada, Venkataraman Dharuman, Huangxian Ju, Ramendra Sundar Dey, Yangping Wen
Correction for 'One-step coelectrodeposition-assisted layer-by-layer assembly of gold nanoparticles and reduced graphene oxide and its self-healing three-dimensional nanohybrid for an ultrasensitive DNA sensor' by Jayakumar Kumarasamy, et al., Nanoscale, 2018, DOI: 10.1039/c7nr06952a.
January 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29336463/protein-corona-in-drug-delivery-for-multimodal-cancer-therapy-in-vivo
#20
Eugenia Li Ling Yeo, Patricia Soo Ping Thong, Khee Chee Soo, James Chen Yong Kah
The protein corona is inevitably formed on nanoparticles (NPs) when they are introduced in vivo and has been associated with a reduction in targeting yield, immune recognition and rapid blood clearance, leading to poor tumor accumulation. We have recently shown that it is possible to exploit the protein corona for drug delivery by exploiting it for loading and triggering the release of a photosensitizer Chlorin e6 (Ce6) for simultaneous photodynamic (PDT) and photothermal therapy (PTT) in vitro. Here, we extended our previous in vitro studies to evaluate its effectiveness in vivo...
January 16, 2018: Nanoscale
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