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https://www.readbyqxmd.com/read/28945012/enhanced-egfr-targeting-activity-of-plasmonic-nanostructures-with-engineered-ge11-peptide
#1
Francesca Biscaglia, Senthilkumar Rajendran, Paolo Conflitti, Clara Benna, Roberta Sommaggio, Lucio Litti, Simone Mocellin, Gianfranco Bocchinfuso, Antonio Rosato, Antonio Palleschi, Donato Nitti, Marina Gobbo, Moreno Meneghetti
Plasmonic nanostructures show important properties for biotechnological applications, but they have to be guided on the target for exploiting their potentialities. Antibodies are the natural molecules for targeting. However, their possible adverse immunogenic activity and their cost have suggested finding other valid substitutes. Small molecules like peptides can be an alternative source of targeting agents, even if, as single molecules, their binding affinity is usually not very good. GE11 is a small dodecapeptide with specific binding to the epidermal growth factor receptor (EGFR) and low immunogenicity...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944816/decoration-of-reduced-graphene-oxide-by-gold-nanoparticles-an-enhanced-negative-photoconductivity
#2
Qi Wang, Yudi Tu, Takashi Ichii, Toru Utsunomiya, Hiroyuki Sugimura, Lifeng Hao, Rongguo Wang, Xiaodong He
Photodetection in a visible light region is important in various applications, including computation, environmental monitoring, biological detection and industrial control. Due to this, research studies to develop photoconductive devices have great significance. We report a study on the photoconductivity of reduced graphene oxide (rGO)/gold nanoparticle (AuNP) nanocomposites, emphasizing the enhancement effect induced by AuNPs. rGO/AuNP photoelectric devices were prepared by spincoating rGO onto an AuNP-array-covered silicon substrate...
September 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28944735/strategies-in-the-design-of-gold-nanoparticles-for-intracellular-targeting-opportunities-and-challenges
#3
Yamin Yang, Lei Ren, Hongjun Wang
With unique physicochemical properties, gold nanoparticles (Au NPs) have demonstrated their potential as drug carriers or therapeutic agents. Effective guidance of Au NPs into specific intracellular destinations becomes increasingly important as we strive to further improve the efficiency of drug delivery and modulate controllable cellular responses. In this review, we summarized recent advances in designing Au NPs with the capabilities of cellular penetration and internalization, endosomal escape, intracellular trafficking and subcellular localization via various approaches including physical injection, tuning the physiochemical parameters of Au NPs, and surface modification with targeting ligands...
October 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28944661/tempo-conjugated-gold-nanoparticles-for-reactive-oxygen-species-scavenging-and-regulation-of-stem-cell-differentiation
#4
Jingchao Li, Jing Zhang, Ying Chen, Naoki Kawazoe, Guoping Chen
Controlling the differentiation of human mesenchymal stem cells (hMSCs) shows a great potential in regenerative medicine. Because overproduced reactive oxygen species (ROS) have obvious inhibitory effect on the differentiation and functions of hMSCs, it is highly desirable to develop effective strategy for ROS scavenging and stem cell differentiation controlling. In this study, gold nanoparticles (Au NPs) with an average size of 40 nm were conjugated with 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) to endow them with ROS scavenging capacity while holding the beneficial effect of Au NPs...
September 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28944089/superior-stability-of-au-sio2-compared-to-au-tio2-catalysts-for-the-selective-hydrogenation-of-butadiene
#5
Nazila Masoud, Laurent Delannoy, Herrick Schaink, Ad van der Eerden, Jan Willem de Rijk, Tiago A G Silva, Dipanjan Banerjee, Johannes D Meeldijk, Krijn P de Jong, Catherine Louis, Petra E de Jongh
Supported gold nanoparticles are highly selective catalysts for a range of both liquid-phase and gas-phase hydrogenation reactions. However, little is known about their stability during gas-phase catalysis and the influence of the support thereon. We report on the activity, selectivity, and stability of 2-4 nm Au nanoparticulate catalysts, supported on either TiO2 or SiO2, for the hydrogenation of 0.3% butadiene in the presence of 30% propene. Direct comparison of the stability of the Au catalysts was possible as they were prepared via the same method but on different supports...
September 1, 2017: ACS Catalysis
https://www.readbyqxmd.com/read/28942160/gold-nanoconjugates-reinforce-the-potency-of-conjugated-cisplatin-and-doxorubicin
#6
Sana Iram, Manaal Zahera, Salman Khan, Imran Khan, Asad Syed, Abu Ayoobul Ansary, Fuad Ameen, Omar H M Shair, Mohd Sajid Khan
Osteosarcoma or osteogenic sarcoma is the most common and prevalent cancerous tumor of bone and occurs especially in children and teens. Recent treatment strategy includes a combination of both chemotherapy and surgeries. Although, the use of single drug-based chemotherapy treatment remains unsatisfactory. Therefore, combinatorial therapy has emerged as a potential strategy for treatment with limited side- effects. Here, we evaluated the combinatorial anticancerous effect of cisplatin (CIS) and doxorubicin (DOX) bioconjugated bromelain encapsulated gold nanoparticles (B-AuNPs conjugated CIS and DOX) in the treatment of osteosarcoma...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28941777/new-pyrimidine-based-ligand-capped-gold-and-platinum-nano-particles-synthesis-characterization-antimicrobial-antioxidant-dna-interaction-and-in-vitro-anticancer-activities
#7
M Sankarganesh, P Adwin Jose, J Dhaveethu Raja, M P Kesavan, M Vadivel, J Rajesh, R Jeyamurugan, R Senthil Kumar, S Karthikeyan
In this research work, we have synthesized new pyrimidine based Schiff base ligand, 2-((4,6-dimethoxypyrimidine-2-yl)methyleneenamino)-6-methoxyphenol (DPMM) capped gold (Au) and platinum (Pt) nanoparticles (NPs) by modified Brust-Schiffrin method. The characteristics of DPMM-Au NPs and DPMM-Pt NPs have been examined by UV-Visible, FTIR, SEM, TEM and powder XRD analysis. SEM analysis result shows that surface morphology of the DPMM-Au NPs and DPMM-Pt NPs are in granular and spherical shape, correspondingly...
September 18, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28941223/fabrication-of-calcium-phosphate-based-nanocomposites-incorporating-dna-origami-gold-nanorods-and-anticancer-drugs-for-biomedical-applications
#8
Hongbo Zhang, Xiangmeng Qu, Hong Chen, Haixin Kong, Ruihua Ding, Dong Chen, Xu Zhang, Hao Pei, Hélder A Santos, Mingtan Hai, David A Weitz
DNA origami is designed by folding DNA strands at the nanoscale with arbitrary control. Due to its inherent biological nature, DNA origami is used in drug delivery for enhancement of synergism and multidrug resistance inhibition, cancer diagnosis, and many other biomedical applications, where it shows great potential. However, the inherent instability and low payload capacity of DNA origami restrict its biomedical applications. Here, this paper reports the fabrication of an advanced biocompatible nano-in-nanocomposite, which protects DNA origami from degradation and facilities drug loading...
September 22, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28939602/synergistic-toxicity-of-copper-and-gold-compounds-in-cupriavidus-metallidurans
#9
Nicole Wiesemann, Lucy Bütof, Martin Herzberg, Gerd Hause, Lutz Berthold, Barbara Etschmann, Joël Brugger, Gema Martinez-Criado, Dirk Dobritzsch, Sacha Baginsky, Frank Reith, Dietrich H Nies
The bacterium Cupriavidus metallidurans is capable of reducing toxic gold(I/III)-complexes and biomineralizing them into metallic gold (Au) nanoparticles, thereby mediating the (trans)formation of Au nuggets. In Au-rich soils, most transition metals do not interfere with the resistance of this bacterium to toxic mobile Au-complexes and can be removed from the cell by plasmid-encoded metal efflux systems. Copper is a noticeable exception: the presence of Au-complexes and Cu-ions results in synergistic toxicity, which is accompanied by an increased cytoplasmic Cu content and formation of Au nanoparticles in the periplasm...
September 22, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28938799/x-ray-reflectivity-studies-on-the-mixed-langmuir-blodgett-monolayers-of-thiol-capped-gold-nanoparticle-dppc-and-sds
#10
Yi-Tang Chen, Han-Shiou Su, Chin-Hua Hung, Po-Wei Yang, Yuan Hu, Tsang-Lang Lin, Ming-Tao Lee, U-Ser Jeng
Langmuir-Blodgett monolayers of the thiolated gold nanoparticles mixed with DPPC/SDS were investigated by combining the X-ray reflectivity, grazing-incident scattering, and TEM analyses to reveal the in-depth and in-plane organization and the 2D morphology of such mixed monolayers. It was found that the addition of charged single tail surfactant to the thiolated Au nanoparticle monolayer helps to stabilize the Au nanoparticle monolayer and to strengthen the mechanical property of the mixed monolayer film. For mixing with lipids, it was found that the thiolated gold nanoparticles could be pushed on top of the lipid monolayer when the mixed monolayer is compressed...
September 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28938186/electrochemiluminescence-resonance-energy-transfer-system-between-gnrs-and-ru-bpy-3-2-application-in-magnetic-aptasensor-for-%C3%AE-amyloid
#11
Hong Ke, Haifeng Sha, Yinfang Wang, Weiwei Guo, Xin Zhang, Zhiming Wang, Chusen Huang, Nengqin Jia
Electrochemiluminescent (ECL) assay has gradually drawn increasing interest in the biomedical analysis. This paper proposed a new methodology for ultrasensitive and facile detection of Alzheimer's disease marker β-amyloid (Aβ) by fabricating a sandwich-type ECL sensing platform. Herein, electrochemiluminescence resonance energy transfer (ECL-RET) was employed to determine Aβ concentration, which can be attributed to the quenching effect from RET between Ru(bpy)3(2+) and gold nanorods (GNRs) acting as ECL-RET electron donor and acceptor, respectively...
September 14, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28937732/reducing-agent-assisted-excessive-galvanic-replacement-mediated-seed-mediated-synthesis-of-porous-gold-nanoplates-and-highly-efficient-gene-thermo-cancer-therapy
#12
Seounghun Kang, Kyunglee Kang, Hyun Huh, Hyungjun Kim, Sung-Jin Chang, Tae Jung Park, Ki Soo Chang, Dal-Hee Min, Hongje Jang
Porous Au nanoplates (pAuNPs) were manufactured by a reducing agent-assisted galvanic replacement reaction on Ag nanoplates using a seed-mediated synthetic approach. Two core additives, polyvinylpyrrolidone and L-ascorbic acid, prevented fragmentation and proceeded secondary growth. By controlling the concentration of the additives and the amount of replacing ion AuCl4-, various nanostructures including nanoplates with holes, nanoframes, porous nanoplates, and bumpy nanoparticles with unity and homogeneity were synthesized...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28937661/a-spectral-probe-for-detection-of-aluminum-iii-ions-using-surface-functionalized-gold-nanoparticles
#13
Surendra Shinde, Dae-Young Kim, Rijuta Ganesh Saratale, Asad Syed, Fuad Ameen, Gajanan Ghodake
A simple green route has been developed for the synthesis of casein peptide functionalized gold nanoparticles (AuNPs), in which casein peptide acts as a reducing as well as the stabilizing agent. In this report, AuNPs have been characterized on the basis of spectroscopic and microscopic results; which showed selective and sensitive response toward Al(3+) in aqueous media, and Al(3+) induces aggregation of AuNPs. The sensing study performed for Al(3+) revealed that the color change from red to blue was due to a red-shift in the surface plasmon resonance (SPR) band and the formation of aggregated species of AuNPs...
September 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28937584/targeted-delivery-of-sirna-with-ph-responsive-hybrid-gold-nanostars-for-cancer-treatment
#14
Hongyan Zhu, Wanwan Liu, Ziting Cheng, Ke Yao, Yu Yang, Bohui Xu, Gaoxing Su
In this work, we report the engineering of gold nanostars (GNS) to deliver small interfering RNA (siRNA) into HepG2 cells. The ligand DG-PEG-Lipoic acid (LA)-Lys-9R (hydrazone) was designed to functionalize GNS, and create the nanoparticles named as 9R/DG-GNS (hydrazone). In the ligand, 2-deoxyglucose (DG) is the targeting molecule, polyethylene glycol (PEG) helps to improve the dispersity and biocompatibility, 9-poly-d-arginine (9R) is employed to provide a positive surface charge and adsorb negative siRNA, and hydrazone bonds are pH-responsive and can avoid receptor-mediated endosomal recycling...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28937203/plasmonic-effect-of-gold-nanostars-in-highly-efficient-organic-and-perovskite-solar-cells
#15
Riski Titian Ginting, Sandeep Kaur, Dong-Kwon Lim, Jung-Mu Kim, Joong-Hee Lee, Seung Hee Lee, Jae-Wook Kang
Herein, a novel strategy is presented for enhancing light absorption by incorporating gold nanostars (Au NSs) into both the active layer of organic solar cells (OSCs) and the rear-contact hole transport layer (HTL) of perovskite solar cells (PSCs). We demonstrate that the power conversion efficiencies of OSCs and PSCs with embedded Au NSs are improved by 6% and 14%, respectively. We find that pegylated Au NSs are greatly dispersable in chlorobenzene solvent, which enabled complete blending of Au NSs with the active layer...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28937168/supracolloidal-chains-of-patchy-micelles-of-diblock-copolymers-with-in-situ-synthesized-nanoparticles
#16
Sukwoo Jang, Kyungtae Kim, Jonghyuk Jeon, Donghwi Kang, Byeong-Hyeok Sohn
Supracolloidal chains of diblock copolymer micelles were functionalized with gold and silver nanoparticles (NPs). Both NPs were independently synthesized in situ in the core of spherical micelles which were then converted to patchy micelles. With these patchy micelles as colloidal monomers, supracolloidal chains were polymerized by combining the patches of neighboring micelles. Since all micelles contained NPs, NPs were incorporated in every repeat unit of chains. In addition, a single gold NP was synthesized in the micellar core in contrast to several silver NPs so that we differentiated the chains with Au NPs from those with Ag NPs by the number of NPs in the repeat unit as well as by plasmonic bands in UV-Vis spectra...
September 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28936509/x-ray-responsive-nanoparticles-with-triggered-release-of-nitrite-a-precursor-of-reactive-nitrogen-species-for-enhanced-cancer-radiosensitization
#17
Fang Liu, Junzhe Lou, Dimitre Hristov
Remotely and locally triggered release of therapeutic species by X-ray irradiation is highly desired to enhance the efficacy of radiotherapy. However, the development of such X-ray responsive nanosystems remains a challenge, especially in response to high energy clinically relevant X-ray radiation. Herein, we report novel nitroimidazole ligated gold nanoparticles (AuNPs) that synergistically function to release nitrite, an important precursor for nitric oxide and reactive nitrogen species that sensitize cancer cells, upon radiation with clinically used 6 MeV X-rays, while no release was detected without radiation...
September 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28935538/nano-gold-assisted-highly-conducting-and-biocompatible-bacterial-cellulose-pedot-pss-films-for-biology-device-interface-applications
#18
Shaukat Khan, Mazhar Ul-Islam, Muhammad Wajid Ullah, Muhammad Israr, Jae Hyun Jang, Joong Kon Park
This study reports the fabrication of highly conducting and biocompatible bacterial cellulose (BC)-gold nanoparticles (AuNPs)-poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) (BC-AuNPs-PEDOT:PSS) composites for biology-device interface applications. The composites were fabricated using ex situ incorporation of AuNPs and PEDOT:PSS into the BC matrix. Structural characterization, using scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and x-ray diffraction (XRD) analysis, confirmed the uniform nature of the synthesized BC-AuNPs and BC-AuNPs-PEDOT:PSS composites...
September 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28934609/quantitative-measurement-of-sodium-polystyrene-sulfonate-adsorption-onto-ctab-capped-gold-nanoparticles-reveals-hard-and-soft-coronas
#19
Celina M Harris, Savannah G Miller, Kurt Andresen, Lucas B Thompson
Accumulated evidence indicates that nanoparticle behavior in complex biological environments strongly depends on the nanoparticles' surface chemistry. A common way to modify nanoparticles is to deposit oppositely charged molecules on the surfaces in a Layer-by-Layer fashion to build up thin films of polymers. While this polymer coating is a well-developed technique, the quantification of polymers deposited and physical mechanism of polymer deposition remain relatively unstudied. In this work CTAB capped gold nanoparticles, synthesized in a flow reactor, are coated with sodium polystyrene sulfonate and purified through a series of equilibrium dialysis steps...
September 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28934114/antimicrobial-nanomaterials-why-evolution-matters
#20
Joseph L Graves, Misty Thomas, Jude Akamu Ewunkem
Due to the widespread occurrence of multidrug resistant microbes there is increasing interest in the use of novel nanostructured materials as antimicrobials. Specifically, metallic nanoparticles such as silver, copper, and gold have been deployed due to the multiple impacts they have on bacterial physiology. From this, many have concluded that such nanomaterials represent steep obstacles against the evolution of resistance. However, we have already shown that this view is fallacious. For this reason, the significance of our initial experiments are beginning to be recognized in the antimicrobial effects of nanomaterials literature...
September 21, 2017: Nanomaterials
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