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Vaccine derived poliovirus

Richter Razafindratsimandresy, Ondrej Mach, Jean-Michel Heraud, Barivola Bernardson, William C Weldon, M Steven Oberste, Roland W Sutter
Background: Vaccine-derived polioviruses (VDPV) outbreaks typically occur in areas of low poliovirus immunity. Madagascar successfully eradicated wild poliovirus in 1997; however, multiple VDPV outbreaks have occurred since then, and numerous vaccination campaigns have been carried out to control the VDPV outbreaks. We conducted a survey of poliovirus neutralizing antibodies among Malagasy children to assess performance of vaccination campaigns and estimate the risk of future VDPV outbreaks...
March 2018: Heliyon
(no author information available yet)
No abstract text is available yet for this article.
March 16, 2018: Relevé épidémiologique Hebdomadaire
Mary M Alleman, Rohit Chitale, Cara C Burns, Jane Iber, Naomi Dybdahl-Sissoko, Qi Chen, Djo-Roy Van Koko, Raimi Ewetola, Yogolelo Riziki, Hugo Kavunga-Membo, Cheikh Dah, Rija Andriamihantanirina
The last confirmed wild poliovirus (WPV) case in Democratic Republic of the Congo (DRC) had paralysis onset in December 2011 (1). DRC has had cases of vaccine-derived polioviruses (VDPVs) documented since 2004 (Table 1) (1-6). After an outbreak of 30 circulating VDPV type 2 (cVDPV2) cases during 2011-2012, only five VDPV2 cases were reported during 2013-2016 (Table 1) (1-6). VDPVs can emerge from oral poliovirus vaccine (OPV types 1, 2, or 3; Sabin) polioviruses that have genetically mutated resulting in reversion to neurovirulence...
March 16, 2018: MMWR. Morbidity and Mortality Weekly Report
Mohammadreza Shaghaghi, Saeed Soleyman-Jahi, Hassan Abolhassani, Reza Yazdani, Gholamreza Azizi, Nima Rezaei, Mohamed-Ridha Barbouche, Mark A McKinlay, Asghar Aghamohammadi
Widespread administration of oral poliovirus vaccine (OPV) has decreased global incidence of poliomyelitis by ≈99.9%. However, the emergence of vaccine-derived polioviruses (VDPVs) is threatening polio-eradication program. Primary immunodeficiency (PID) patients are at higher risks of vaccine-associated paralytic poliomyelitis (VAPP) and prolonged excretion of immunodeficiency-associated VDPV (iVDPV). We searched Embase, Medline, Science direct, Scopus, Web of Science, and CDC and WHO databases by 30 September 2016, for all reports of iVDPV cases...
February 22, 2018: Vaccine
Ali Faisal Saleem, Mohammad Tahir Yousafzai, Ondrej Mach, Asia Khan, Farheen Quadri, William C Weldon, M Steven Oberste, Syed S Zaidi, Muhammad M Alam, Roland W Sutter, Anita K M Zaidi
BACKGROUND: Outbreaks of circulating vaccine derived polioviruses type 2 (cVDPV2) remain a risk to poliovirus eradication in an era without live poliovirus vaccine containing type 2 in routine immunization. We evaluated existing outbreak response strategies recommended by the World Health Organization (WHO) for control of cVDPV2 outbreaks. METHODS: Seronegative children for poliovirus type 2 (PV2) at 22 weeks of life were assigned to one of four study groups and received respectively (1) one dose of trivalent oral poliovirus vaccine (tOPV); (2) monovalent OPV 2 (mOPV2); (3) tOPV together with a dose of inactivated poliovirus vaccine (IPV); or (4) mOPV2 with monovalent high-potency IPV type 2...
February 21, 2018: Vaccine
Jing Shaw, Jaume Jorba, Kun Zhao, Jane Iber, Qi Chen, Festus Adu, Adekunle Adeniji, David Bukbuk, Marycelin Baba, Elizabeth Henderson, Naomi Dybdahl-Sissoko, Sharla Macdonald, William C Weldon, Nicksy Gumede, M Steven Oberste, Olen M Kew, Cara C Burns
We followed the dynamics of capsid amino acid replacement among 403 Nigerian outbreak isolates of type 2 circulating vaccine-derived poliovirus (cVDPV2) from 2005 through 2011. Four different functional domains were analyzed: 1) neutralizing antigenic (NAg) sites, 2) residues binding the poliovirus receptor (PVR), 3) VP1 residues 1-32, and 4) the capsid structural core. Amino acid replacements mapped to 37 of 43 positions across all 4 NAg sites; the most variable and polymorphic residues were in NAg sites 2 and 3b...
February 14, 2018: Journal of Virology
Oumar Guindo, Ondrej Mach, Seydou Doumbia, Daniel K Ekra, Abdoul H Beavogui, William C Weldon, M Steven Oberste, Roland W Sutter
We conducted a serological survey of anti-polio antibodies in polio high-risk areas of Mali, Guinea and Cote d'Ivoire to assess risk of future poliovirus outbreaks. Random community sampling of children 6-11 and 36-48 months-old was conducted; neutralizing antibodies against poliovirus were detected using microneutralization assay. We analysed 1059/1064 (99.5%) of enrolled children. Seroprevalence to poliovirus type 1 (PV1) across all age groups and locations ranged between 92 and 100%, for PV2 it was 77-100%, and 89-95% for PV3...
February 14, 2018: Vaccine
Radboud J Duintjer Tebbens, Mark A Pallansch, Stephen L Cochi, Derek T Ehrhardt, Noha H Farag, Stephen C Hadler, Lee M Hampton, Maureen Martinez, Steve G F Wassilak, Kimberly M Thompson
Due to security, access, and programmatic challenges in areas of Pakistan and Afghanistan, both countries continue to sustain indigenous wild poliovirus (WPV) transmission and threaten the success of global polio eradication and oral poliovirus vaccine (OPV) cessation. We fitted an existing differential-equation-based poliovirus transmission and OPV evolution model to Pakistan and Afghanistan using four subpopulations to characterize the well-vaccinated and undervaccinated subpopulations in each country. We explored retrospective and prospective scenarios for using inactivated poliovirus vaccine (IPV) in routine immunization or supplemental immunization activities (SIAs)...
January 3, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
Niila V V Saarinen, Jutta E Laiho, Sarah J Richardson, Marie Zeissler, Virginia M Stone, Varpu Marjomäki, Tino Kantoluoto, Marc S Horwitz, Amirbabak Sioofy-Khojine, Anni Honkimaa, Minna M Hankaniemi, Malin Flodström-Tullberg, Heikki Hyöty, Vesa P Hytönen, Olli H Laitinen
Enteroviruses (EVs) are common RNA viruses that cause diseases ranging from rash to paralytic poliomyelitis. For example, EV-A and EV-C viruses cause hand-foot and mouth disease and EV-B viruses cause encephalitis and myocarditis, which can result in severe morbidity and mortality. While new vaccines and treatments for EVs are under development, methods for studying and diagnosing EV infections are still limited and therefore new diagnostic tools are required. Our aim was to produce and characterize new antibodies that work in multiple applications and detect EVs in tissues and in vitro...
January 8, 2018: Scientific Reports
Kun Zhao, Jaume Jorba, Jing Shaw, Jane Iber, Qi Chen, Kelley Bullard, Olen M Kew, Cara C Burns
Public health response to vaccine-derived poliovirus (VDPV) that is transmitted from person to person (circulating VDPV [cVDPV]) differs significantly from response to virus that replicates in individuals with primary immunodeficiency (immunodeficiency-associated VDPV [iVDPV]). cVDPV outbreaks require a community immunization response, whereas iVDPV chronic infections require careful patient monitoring and appropriate individual treatment. To support poliovirus outbreak response, particularly for type 2 VDPV, we investigated the genetic distinctions between cVDPV2 and iVDPV2 sequences...
2017: Computational and Structural Biotechnology Journal
Maria Dolores Fernandez-Garcia, Manasi Majumdar, Ousmane Kebe, Aichatou D Fall, Moussa Kone, Mouctar Kande, Moustapha Dabo, Mohamed Salif Sylla, Djenou Sompare, Wayne Howard, Ousmane Faye, Javier Martin, Kader Ndiaye
During the 2014-2015 outbreak of Ebola virus disease in Guinea, 13 type 2 circulating vaccine-derived polioviruses (cVDPVs) were isolated from 6 polio patients and 7 healthy contacts. To clarify the genetic properties of cVDPVs and their emergence, we combined epidemiologic and virologic data for polio cases in Guinea. Deviation of public health resources to the Ebola outbreak disrupted polio vaccination programs and surveillance activities, which fueled the spread of neurovirulent VDPVs in an area of low vaccination coverage and immunity...
January 2018: Emerging Infectious Diseases
Hai-Bo Wang, Hui-Ming Luo, Li Li, Chun-Xiang Fan, Li-Xin Hao, Chao Ma, Qi-Ru Su, Hong Yang, Kathleen H Reilly, Hua-Qing Wang, Ning Wen
BACKGROUND: The goal of polio eradication is to complete elimination and containment of all wild, vaccine-related and Sabin polioviruses. Vaccine-derived poliovirus (VDPV) surveillance in China from 2001-2013 is summarized in this report, which has important implications for the global polio eradication initiative. METHODS: Acute flaccid paralysis (AFP) cases and their contacts with VDPVs isolated from fecal specimens were identified in our AFP surveillance system or by field investigation...
December 2, 2017: BMC Infectious Diseases
Aslam Pervaiz, Chukwuma Mbaeyi, Mirza Amir Baig, Ashley Burman, Jamal A Ahmed, Sharifa Akter, Fayaz A Jatoi, Abdirahman Mahamud, Rana Jawad Asghar, Naila Azam, Muhammad Nadeem Shah, Mumtaz Ali Laghari, Kamaluddin Soomro, Mufti Zubair Wadood, Derek Ehrhardt, Rana M Safdar, Noha Farag
Following the declaration of eradication of wild poliovirus (WPV) type 2 in September 2015, trivalent oral poliovirus vaccine (tOPV) was withdrawn globally to reduce the risk for type 2 vaccine-derived poliovirus (VDPV2) transmission; all countries implemented a synchronized switch to bivalent OPV (type 1 and 3) in April 2016 (1,2). Any isolation of VDPV2 after the switch is to be treated as a potential public health emergency and might indicate the need for supplementary immunization activities (3,4). On August 9, 2016, VDPV2 was isolated from a sewage sample taken from an environmental surveillance site in Hyderabad, Sindh province, Pakistan...
December 1, 2017: MMWR. Morbidity and Mortality Weekly Report
Ekaterina Korotkova, Majid Laassri, Tatiana Zagorodnyaya, Svetlana Petrovskaya, Elvira Rodionova, Elena Cherkasova, Anatoly Gmyl, Olga E Ivanova, Tatyana P Eremeeva, Galina Y Lipskaya, Vadim I Agol, Konstantin Chumakov
Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing) of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eliminated by recombination. The presumed low fitness of these segments could be linked to mutations acquired upon derivation of the vaccine strains and/or may have been present in wild-type parents of Sabin viruses...
November 22, 2017: Viruses
Ali F Saleem, Ondrej Mach, Mohammad T Yousafzai, Asia Khan, William C Weldon, M Steven Oberste, Syed S Zaidi, Muhammad M Alam, Farheen Quadri, Roland W Sutter, Anita K M Zaidi
Background: We assessed immunity against polioviruses induced with new Pakistani immunization schedule and compared it with alternative immunization schedules. Methods: Newborns were randomized to receive one of the following vaccination schedules, administered at birth, 6, 10, and 14 weeks of age. Arm A: 4x IPV; Arm B: 4x bOPV; Arm C and D: bOPV, bOPV, bOPV, bOPV+ inactivated poliovirus vaccine (IPV); Arm E: 4x trivalent oral poliovirus vaccine (tOPV). At 22 weeks of age, children received one challenge dose of tOPV, and children in arm D received one additional IPV dose...
November 6, 2017: Journal of Infectious Diseases
(no author information available yet)
No abstract text is available yet for this article.
November 3, 2017: Relevé épidémiologique Hebdomadaire
Joanne Hassan, Laura Wangai, Peter Borus, Christopher Khayeka-Wandabwa, Lucy Wanja Karani, Mercy Kithinji, Michael Kiptoo
BACKGROUND: Poliomyelitis is an acute viral infection caused by poliovirus and transmitted via the fecal-oral route. The causative agent is one of the three serotypes of poliovirus (serotypes 1, 2, 3) that differ slightly in capsid protein. Prolonged vaccine-related poliovirus shedding in human immunodeficiency virus (HIV) positive individuals has been linked to possible reservoir for reintroduction of polioviruses after eradication. The study therefore aimed at estimating the duration for vaccine-related poliovirus shedding among potentially and HIV-infected persons...
November 3, 2017: BMC Research Notes
Jaume Jorba, Ousmane M Diop, Jane Iber, Elizabeth Henderson, Roland W Sutter, Steven G F Wassilak, Cara C Burns
In 1988, the World Health Assembly launched the Global Polio Eradication Initiative (GPEI) (1). Among the three wild poliovirus (WPV) serotypes, only type 1 (WPV1) has been detected since 2012. Since 2014, detection of WPV1 has been limited to three countries, with 37 cases in 2016 and 11 cases in 2017 as of September 27. The >99.99% decline worldwide in polio cases since the launch of the GPEI is attributable to the extensive use of the live, attenuated oral poliovirus vaccine (OPV) in mass vaccination campaigns and comprehensive national routine immunization programs...
November 3, 2017: MMWR. Morbidity and Mortality Weekly Report
Grace Macklin, Yi Liao, Marina Takane, Kathleen Dooling, Stuart Gilmour, Ondrej Mach, Olen M Kew, Roland W Sutter
Individuals with primary immunodeficiency disorder may excrete poliovirus for extended periods and will constitute the only remaining reservoir of virus after eradication and withdrawal of oral poliovirus vaccine. Here, we analyzed the epidemiology of prolonged and chronic immunodeficiency-related vaccine-derived poliovirus cases in a registry maintained by the World Health Organization, to identify risk factors and determine the length of excretion. Between 1962 and 2016, there were 101 cases, with 94/101 (93%) prolonged excretors and 7/101 (7%) chronic excretors...
2017: Frontiers in Immunology
Kevin A McCarthy, Guillaume Chabot-Couture, Michael Famulare, Hil M Lyons, Laina D Mercer
BACKGROUND: Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associated paralytic poliomyelitis. OPV2 is also transmissible and can establish circulating lineages, called circulating vaccine-derived polioviruses (cVDPVs), which can also cause paralytic outbreaks. Thus, in April 2016, OPV2 was removed from immunization activities worldwide...
October 4, 2017: BMC Medicine
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