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https://www.readbyqxmd.com/read/29149420/blood-clearance-and-occupational-exposure-for-177-lu-dotatate-compared-to-177-lu-psma-radionuclide-therapy
#1
Mohammad Abuqbeitah, Mustafa Demir, Lebriz Uslu-Beşli, Nami Yeyin, Kerim Sönmezoğlu
The main target of this work is to examine blood clearance and external exposure for (177)Lu-DOTATATE compared with new emerging (177)Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq (177)Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq (177)Lu-PSMA. Dose rates were measured at several distances and time points up to 120 h after treatment. Blood samples were collected conjunctively after infusion. Caregiver's cumulative dose was measured by means of an OSL (optically stimulated luminescence) dosimeter for 4-5 days and medical staff's dose was also estimated using electronic personal dosimeters...
November 17, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29148578/in-order-to-function-more-fully-as-professionals-and-provide-professional-services-medical-physicists-should-actively-seek-to-be-employed-by-physician-groups-rather-than-by-facilities
#2
David W Jordan, DanielC Pavord, Colin G Orton
Most medical physicists in clinical practice in the United States are employed by hospitals. However, a minority are employed by physician groups, and some believe that this is preferable. This is the claim debated in this month's Point/Counterpoint. This article is protected by copyright. All rights reserved.
November 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29143458/comp-report-cqpr-technical-quality-control-guidelines-for-ct-simulators
#3
Philippe Després, Stewart Gaede
The Canadian Organization of Medical Physicists (COMP), in close partnership with the Canadian Partnership for Quality Radiotherapy (CPQR) has developed a series of Technical Quality Control (TQC) guidelines for radiation treatment equipment. These guidelines outline the performance objectives that equipment should meet in order to ensure an acceptable level of radiation treatment quality. The TQC guidelines have been rigorously reviewed and field tested in a variety of Canadian radiation treatment facilities...
November 16, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29140824/beginnings-of-astigmatism-understanding-and-management-in-the-19th-century
#4
Andrzej Grzybowski, Piotr Kanclerz
Within the last 200 years, the perception of astigmatism has evolved from that of an infrequent and peculiar defect of the eye to a distortion almost as common as spherical refractive errors. Most of the significant findings on this condition were made in the 19th century, including the first description by Thomas Young (1773-1829) and the introduction of the treatment methods used today. The purpose of this study was to investigate the milestones in the understanding and management of astigmatism that occurred up to the year 1900...
November 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29136248/determination-of-national-diagnostic-reference-levels-in-computed-tomography-examinations-of-iran-by-a-new-quality-control-based-dose-survey-method
#5
Mehdi Sohrabi, Masoumeh Parsi, Fereidoun Mianji
National diagnostic reference levels (NDRLs) of Iran were determined for the four most common CT examinations including head, sinus, chest and abdomen/pelvis. A new 'quality control (QC)-based dose survey method', as developed by us, was applied to 157 CT scanners in Iran (2014-15) with different slice classes, models and geographic spread across the country. The NDRLs for head, sinus, chest and abdomen/pelvis examinations are 58, 29, 12 and 14 mGy for CTDIVol and 750, 300, 300 and 650 mGy.cm for DLP, respectively...
November 10, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29135537/status-and-perception-of-risk-management-in-radiation-therapy-survey-among-korean-medical-physicists
#6
Sohyun Ahn, Dong Oh Shin, Sang Hyoun Choi, Jihye Koo, Soon Sung Lee, Dong-Wook Park, Yoon-Jin Oh, Sohyun Park, Dong Wook Kim
This study was conducted as part of an endeavor to improve the risk management system of radiation therapy departments in the Republic of Korea. An online survey on the status and perception of Korea's medical physicists on risk management in radiation therapy was carried out. A total of 40 domestic radiation oncology departments participated. This survey is divided into three categories: (1) work environment; (2) risk management status; and (3) opinions on how to improve risk management. Based on the results of the survey, the conclusions that can be derived are (1) the majority of respondents have a high interest in the risk management of radiation therapy; (2) the lack of staffing is one cause of risk management difficulties; (3) a risk-related terminology and classification system at the national or professional association level are required; (4) each hospital should create a voluntary reporting system for the handling of incidents; (5) medical physicists should establish incident reporting, analysis and countermeasures; and (6) government should develop education and training programs...
November 10, 2017: Health Physics
https://www.readbyqxmd.com/read/29131344/aerrow-a-probe-format-graphite-calorimeter-for-absolute-dosimetry-of-high-energy-photon-beams-in-the-clinical-environment
#7
James Renaud, Arman Sarfehnia, Julien Bancheri, Jan Seuntjens
In this work, the design, operation, initial experimental evaluation, and characterization of a small-scale graphite calorimeter probe - herein referred to as the Aerrow - developed for routine use in the clinical environment, is described. Similar in size and shape to a Farmer type cylindrical ionization chamber, the Aerrow represents the first translation of calorimetry intended for direct use by clinical physicists in the radiotherapy clinic METHODS: Based on a numerically-optimized design obtained in previous work, a functioning Aerrow prototype capable of two independent modes of operation (quasi-adiabatic and isothermal) was constructed in-house...
November 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/29105791/implementation-of-dosimetry-equipment-and-phantoms-at-the-medaustron-light-ion-beam-therapy-facility
#8
Loϊc Grevillot, Markus Stock, Hugo Palmans, Jhonnatan Osorio Moreno, Virgile Letellier, Ralf Dreindl, Alessio Elia, Hermann Fuchs, Antonio Carlino, Stanislav Vatnitsky
PURPOSE: To describe the implementation of dosimetry equipment and phantoms into clinical practice of light ion beam therapy facilities. This work covers standard dosimetry equipment such as computerized water scanners, films, 2D-array, thimble and plane parallel ionization chambers, but also dosimetry equipment specifically devoted to the pencil beam scanning delivery technique such as water columns, scintillating screens or multi-layer ionization chambers. METHOD: Advanced acceptance testing procedures developed at MedAustron and complementary to the standard acceptance procedures proposed by the manufacturer are presented...
November 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/29105235/the-biology-and-polymer-physics-underlying-large-scale-chromosome-organization
#9
REVIEW
Shelley Sazer, Helmut Schiessel
Chromosome large-scale organization is a beautiful example of the interplay between physics and biology. DNA molecules are polymers and thus belong to the class of molecules for which physicists have developed models and formulated testable hypotheses to understand their arrangement and dynamic properties in solution, based on the principles of polymer physics. Biologists documented and discovered the biochemical basis for the structure, function and dynamic spatial organization of chromosomes in cells. The underlying principles of chromosome organization have recently been revealed in unprecedented detail using high-resolution chromosome capture technology that can simultaneously detect chromosome contact sites throughout the genome...
November 3, 2017: Traffic
https://www.readbyqxmd.com/read/29104835/online-adaptive-radiation-therapy-implementation-of-a-new-process-of-care
#10
James Lamb, Minsong Cao, Amar Kishan, Nzhde Agazaryan, David H Thomas, Narek Shaverdian, Yingli Yang, Suzette Ray, Daniel A Low, Ann Raldow, Michael L Steinberg, Percy Lee
Onboard magnetic resonance imaging (MRI) guided radiotherapy is now clinically available in nine centers in the world. This technology has facilitated the clinical implementation of online adaptive radiotherapy (OART), or the ability to alter the daily treatment plan based on tumor and anatomical changes in real-time while the patient is on the treatment table. However, due to the time sensitive nature of OART, implementation in a large and busy clinic has many potential obstacles as well as patient-related safety considerations...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29104659/estimation-of-effective-doses-in-pediatric-x-ray-computed-tomography-examination
#11
Hideki Obara, Midori Takahashi, Kazuya Kudou, Yasushi Mariya, Yoshihiro Takai, Ikuo Kashiwakura
X-ray computed tomography (CT) images are used for diagnostic and therapeutic purposes in various medical disciplines. In Japan, the number of facilities that own diagnostic CT equipment, the number of CT examinations and the number of CT scanners increased by ~1.4-fold between 2005 and 2011. CT operators (medical radiological technologists, medical physicists and physicians) must understand the effective doses for examinations at their own institutions and carefully approach each examination. In addition, the patients undergoing the examination (as well as his/her family) must understand the effective dose of each examination in the context of the cumulative dose...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29091280/changes-and-demands-in-the-higher-education-sector-are-increasingly-making-advanced-degree-medical-physics-programs-non-viable-and-the-profession-will-have-to-develop-a-new-model-for-delivering-such-education
#12
Andrew Fielding, Joann I Prisciandaro, Colin G Orton
At universities, advanced degree programs in Medical Physics tend to have relatively few students compared to, for example, programs in other Physics sub-specialties. This tends to make them relatively more expensive to operate and, since universities are always looking for ways to reduce costs, there is some concern that such programs will cease to be affordable and other ways to educate medical physicists should be developed. This is the premise debated in this month's Point/Counterpoint. This article is protected by copyright...
November 1, 2017: Medical Physics
https://www.readbyqxmd.com/read/29089359/transcriptional-precision-and-accuracy-in-development-from-measurements-to-models-and-mechanisms
#13
REVIEW
Lital Bentovim, Timothy T Harden, Angela H DePace
During development, genes are transcribed at specific times, locations and levels. In recent years, the emergence of quantitative tools has significantly advanced our ability to measure transcription with high spatiotemporal resolution in vivo Here, we highlight recent studies that have used these tools to characterize transcription during development, and discuss the mechanisms that contribute to the precision and accuracy of the timing, location and level of transcription. We attempt to disentangle the discrepancies in how physicists and biologists use the term 'precision' to facilitate interactions using a common language...
November 1, 2017: Development
https://www.readbyqxmd.com/read/29082599/failure-modes-and-effects-analysis-fmea-for-gamma-knife-radiosurgery
#14
Andy Yuanguang Xu, Jagdish Bhatnagar, Greg Bednarz, John Flickinger, Yoshio Arai, Jonet Vacsulka, Wenzheng Feng, Edward Monaco, Ajay Niranjan, L Dade Lunsford, M Saiful Huq
PURPOSE: Gamma Knife radiosurgery is a highly precise and accurate treatment technique for treating brain diseases with low risk of serious error that nevertheless could potentially be reduced. We applied the AAPM Task Group 100 recommended failure modes and effects analysis (FMEA) tool to develop a risk-based quality management program for Gamma Knife radiosurgery. METHODS: A team consisting of medical physicists, radiation oncologists, neurosurgeons, radiation safety officers, nurses, operating room technologists, and schedulers at our institution and an external physicist expert on Gamma Knife was formed for the FMEA study...
October 29, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29077894/radiation-oncology-in-canada
#15
Meredith Giuliani, Mary Gospodarowicz
In this article we provide an overview of the Canadian healthcare system and the cancer care system in Canada as it pertains to the governance, funding and delivery of radiotherapy programmes. We also review the training and practice for radiation oncologists, medical physicists and radiation therapists in Canada. We describe the clinical practice of radiation medicine from patients' referral, assessment, case conferences and the radiotherapy process. Finally, we provide an overview of the practice culture for Radiation Oncology in Canada...
October 25, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29072285/cancer-biology-still-needs-physicists
#16
Robert Austin
No abstract text is available yet for this article.
October 24, 2017: Nature
https://www.readbyqxmd.com/read/29061550/percutaneous-coronary-intervention-for-the-left-main-stem-and-other-bifurcation-lesions-the-12-th-consensus-document-from-the-european-bifurcation-club
#17
Jens Flensted Lassen, Francesco Burzotta, Adrian P Banning, Thierry Lefèvre, Olivier Darremont, David Hildick-Smith, Alaide Chieffo, Manuel Pan, Niels Ramsing Holm, Yves Louvard, Goran Stankovic
The European Bifurcation Club (EBC) was initiated in 2004, to support a continuously overview of the field of coronary artery bifurcation interventions and aims to facilitate a scientific discussion and an exchange of ideas on management of bifurcation disease. EBC hosts an annual, two days compact meeting, dedicated to bifurcations, which brings together physicians, pathologists, engineers, biologists, physicists, mathematicians, epidemiologists and statisticians for detailed discussions. Every meeting is finalized with a consensus statement that reflects the unique opportunity of combining the opinion of interventional cardiologists with the opinion of a large variety of other scientists on bifurcation management...
October 24, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29046085/transoral-laser-surgery-for-laryngeal-carcinoma-has-steiner-achieved-a-genuine-paradigm-shift-in-oncological-surgery
#18
A T Harris, A Tanyi, R D Hart, J Trites, M H Rigby, J Lancaster, A Nicolaides, S M Taylor
Transoral laser microsurgery applies to the piecemeal removal of malignant tumours of the upper aerodigestive tract using the CO2 laser under the operating microscope. This method of surgery is being increasingly popularised as a single modality treatment of choice in early laryngeal cancers (T1 and T2) and occasionally in the more advanced forms of the disease (T3 and T4), predominantly within the supraglottis. Thomas Kuhn, the American physicist turned philosopher and historian of science, coined the phrase 'paradigm shift' in his groundbreaking book The Structure of Scientific Revolutions...
October 19, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29030753/successful-implementation-of-virtual-environment-for-radiotherapy-training-vert-in-medical-physics-education-the-university-of-sydney-s-initial-experience-and-recommendations
#19
Yobelli A Jimenez, Christian Rønn Hansen, Prabhjot Juneja, David I Thwaites
This report outlines the University of Sydney's initial experience with the Virtual Environment for Radiotherapy Training (VERT) system in the Master of Medical Physics program. VERT is a commercially available system, simulating linear accelerators, patient computed tomography (CT) sets, plans and treatment delivery. It was purpose built for radiation therapy (RT) education and offers learners the opportunity to gain knowledge and skills within an interactive, risk-free environment. The integration of VERT into the RT physics module of the Master of Medical Physics program was intended to enhance student knowledge and skills relevant to the curriculum's learning objectives, and to alleviate some of the burden associated with student access to clinical equipment...
October 13, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28990864/a-frosty-disagreement-john-tyndall-james-david-forbes-and-the-early-formation-of-the-x-club
#20
Nanna Katrine Lüders Kaalund
How do glaciers move? This seemingly straightforward question provided the backdrop for a heated debate between the physicists John Tyndall (1820-1893) and James David Forbes (1809-1868) in the late 1850s and early 1860s. Forbes described the motion of glaciers as that of a viscous fluid. After visiting the Alps, Tyndall proposed an alternative theory that combined fracture and regelation. The glacial controversy ensued. Yet the debate was never simply about whether glaciers moved like honey, or if they moved by continuously breaking and re-attaching...
October 9, 2017: Annals of Science
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