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Subclinical atherosclerosis AND ectopic fat

A Baragetti, G Pisano, C Bertelli, K Garlaschelli, L Grigore, A L Fracanzani, S Fargion, G D Norata, A L Catapano
BACKGROUND AND AIMS: Abdominal obesity and hepatic steatosis are ectopic fat depots associated with Metabolic Syndrome (MetS). Epicardial Fat Thickness (EFT) is a newly discovered one, increasing with obesity, insulin resistance and MetS. Therefore we studied whether different ectopic fat markers, and EFT in particular, are associated with MetS and markers of subclinical cardiovascular disease. METHODS AND RESULTS: 868 subjects from the PLIC Study were included, EFT, aortic calcifications, carotid Intima-Media Thickness (c-IMT) and echocardiographic parameters were determined by ultrasound; extra-cardiac atherosclerotic lesions were defined in presence of plaques at both carotid and aortic levels...
February 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Mee Kyoung Kim, Hyun Ji Chun, Jin Hee Park, Dong Myung Yeo, Ki-Hyun Baek, Ki-Ho Song, Dong Jin Chung, Hyuk-Sang Kwon
AIMS: Evidence that pancreatic fat accumulation has a role in obesity, metabolic syndrome and type 2 diabetes mellitus (DM) is emerging. However, data on the influence of pancreatic steatosis on subclinical atherosclerosis are lacking. METHODS: We examined 198 patients with type 2 DM. Pancreatic computed tomography (CT) attenuations were assessed using CT imaging. Obesity was defined as BMI ≥ 25 kg/m(2) according to the Asian-specific BMI cut-offs. We defined pancreatic steatosis as pancreatic attenuations below median levels...
December 2014: Diabetes Research and Clinical Practice
Nicholas J Alvey, Alison Pedley, Klara J Rosenquist, Joseph M Massaro, Christopher J O'Donnell, Udo Hoffmann, Caroline S Fox
BACKGROUND: Ectopic fat density is associated with cardiovascular disease (CVD) risk factors above and beyond fat volume. Volumetric measures of ectopic fat have been associated with CVD risk factors and subclinical atherosclerosis. The aim of this study was to investigate the association between fat density and subclinical atherosclerosis. METHODS AND RESULTS: Participants were drawn from the Multi-Detector Computed Tomography (MDCT) substudy of the Framingham Heart Study (n=3079; mean age, 50...
August 28, 2014: Journal of the American Heart Association
Konstantinos Kantartzis, Killian Rittig, Bernd Balletshofer, Jürgen Machann, Fritz Schick, Katarina Porubska, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan
BACKGROUND: The metabolic effects of adiponectin, including insulin sensitivity, seem to become stronger with increasing adiposity. Adiposity may also affect the relationship of adiponectin concentrations with serum lipid profile; markers of inflammation, atherosclerosis, and endothelial function; and ectopic fat accumulation. METHODS: We measured plasma adiponectin concentrations, serum lipids, and serum markers of inflammation, atherosclerosis, and endothelial function in 242 Caucasians without type 2 diabetes...
October 2006: Clinical Chemistry
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