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https://www.readbyqxmd.com/read/27819132/effects-of-concomitant-diabetes-mellitus-and-hyperthyroidism-on-testicular-and-epididymal-histoarchitecture-and-steroidogenesis-in-male-animals
#1
Nazar Ali Korejo, Quan-Wei Wei, Atta Hussain Shah, Fang-Xiong Shi
This study evaluated the effects of comorbid disorders of diabetes and hyperthyroidism in the adult male mice. In total, 32 ICR strain mice were equally distributed into four groups: control (C), diabetic (D), diabetic-plus-hyperthyroid (DH), and hyperthyroid (H). Mice allocated for diabetes received a single intraperitoneal injection of streptozotocin (STZ) at 200 mg/kg body weight. At the onset of diabetes, one group of mice was concomitantly injected levothyroxine (LT4; 0.3 mg/kg body weight) and the other set of animals received the same treatment independently on a daily basis...
2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27785940/therapeutic-effects-of-blue-honeysuckle-on-lesions-of-hyperthyroidism-in-rats
#2
Sang-In Park, Young Joon Lee, Seong Hun Choi, Soo Jin Park, Chang-Hyun Song, Sae-Kwang Ku
Hyperthyroidism is a hypermetabolic syndrome characterized by an overproduction of thyroid hormones, which enhances the hormone-induced oxidative stress responsible for some complications in the liver, heart and muscle. Blue honeysuckle (BH) is an edible berry, rich in polyphenols, especially flavonoids or anthocyanins, known as strong antioxidants. The chemo-protective activities of the berry have been connected to the improvement of symptoms in cancer, diabetes mellitus, tumor or cardiovascular diseases. Therefore, the therapeutic effects of BH were examined in hyperthyroidism rat model...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27740871/brown-adipose-tissue-function-is-enhanced-in-long-lived-male-ames-dwarf-mice
#3
Justin Darcy, Samuel McFadden, Yimin Fang, Joshua A Huber, Chi Zhang, Liou Y Sun, Andrzej Bartke
Ames dwarf mice (Prop1(df/df)) are long-lived due to a loss of function mutation, resulting in deficiency of GH, TSH, and prolactin. Along with a marked extension of longevity, Ames dwarf mice have improved energy metabolism as measured by an increase in their oxygen consumption and heat production, as well as a decrease in their respiratory quotient. Along with alterations in energy metabolism, Ames dwarf mice have a lower core body temperature. Moreover, Ames dwarf mice have functionally altered epididymal white adipose tissue (WAT) that improves, rather than impairs, their insulin sensitivity due to a shift from pro- to anti-inflammatory cytokine secretion...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27604858/a-disputed-evidence-on-obesity-comparison-of-the-effects-of-rcan2-and-rps6kb1-mutations-on-growth-and-body-weight-in-c57bl-6j-mice
#4
Jing Zhao, Shi-Wei Li, Qian-Qian Gong, Ling-Cui Ding, Ye-Cheng Jin, Jian Zhang, Jian-Gang Gao, Xiao-Yang Sun
It is widely accepted that body weight and adipose mass are tightly regulated by homeostatic mechanisms, in which leptin plays a critical role through hypothalamic pathways, and obesity is a result of homeostatic disorder. However, in C57BL/6J mice, we found that Rcan2 increases food intake and plays an important role in the development of age- and diet-induced obesity through a leptin-independent mechanism. RCAN2 was initially identified as a thyroid hormone (T3)-responsive gene in human fibroblasts. Expression of RCAN2 is regulated by T3 through the PI3K-Akt/PKB-mTOR-Rps6kb1 signaling pathway...
September 2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/27567273/immunohistochemical-detection-of-pax8-and-napsin-a-in-canine-thyroid-tumours-comparison-with-thyroglobulin-calcitonin-and-thyroid-transcription-factor-1
#5
J A Ramos-Vara, C B Frank, D DuSold, M A Miller
Expression of thyroid transcription factor (TTF)-1 corroborates a thyroid origin of neoplasms. Thyroglobulin and calcitonin immunohistochemistry (IHC) can distinguish between a follicular and C-cell origin of thyroid tumours, respectively. Pax8 (expressed by normal canine thyroid follicular cells) and napsin A (expressed mainly by C-cells) labelling was compared with labelling for TTF-1, thyroglobulin and calcitonin in 114 canine proliferative thyroid lesions. All 81 follicular tumours expressed thyroglobulin and were negative for calcitonin; 79/81 (98%) of these tumours expressed TTF-1 and Pax8 and 60/81 (74%) expressed napsin A...
November 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/26759137/is-thyroid-hormones-evaluation-of-clinical-value-in-the-work-up-of-males-of-infertile-couples
#6
F Lotti, E Maseroli, N Fralassi, S Degl'Innocenti, L Boni, E Baldi, M Maggi
STUDY QUESTION: Is thyroid hormones (TH) evaluation of clinical value in the work-up of males of infertile couples? STUDY ANSWER: Our results suggest that TH evaluation is not mandatory in the work-up of male infertility. WHAT IS KNOWN ALREADY: A few previous studies performed on a limited series of subjects reported a negative impact of hyper- and hypo-thyroidism on semen volume, sperm concentration, progressive motility and normal morphology...
March 2016: Human Reproduction
https://www.readbyqxmd.com/read/26601074/the-effects-of-thyroid-hormones-on-gene-expression-of-acyl-coenzyme-a-thioesterases-in-adipose-tissue-and-liver-of-mice
#7
Kerstin Krause, Juliane Weiner, Sebastian Hönes, Nora Klöting, Eddy Rijntjes, John T Heiker, Claudia Gebhardt, Josef Köhrle, Dagmar Führer, Karen Steinhoff, Swen Hesse, Lars C Moeller, Anke Tönjes
BACKGROUND: Thyroid hormones (TH) exert pleiotropic effects on glucose and lipid homeostasis. However, it is as yet unclear how TH regulate lipid storage and utilization in order to adapt to metabolic needs. Acyl-CoA thioesterases (ACOTs) have been proposed to play a regulatory role in the metabolism of fatty acids. OBJECTIVES: We investigated the interaction between thyroid dysfunction and Acot expression in adipose tissues and livers of thyrotoxic and hypothyroid mice...
September 2015: European Thyroid Journal
https://www.readbyqxmd.com/read/26382975/toxicological-evaluation-of-smokeless-tobacco-2-year-chronic-toxicity-and-carcinogenicity-feeding-study-in-wistar-han-rats
#8
Eugenia H Theophilus, Johnnie R Hayes, Paul H Ayres, Walter T Morgan, Ryan J Potts, Charles D Garner, Dawn M Fallacara, Milton R Hejtmancik, Allen W Singer
UNLABELLED: A comprehensive 2-year oral chronic toxicity/carcinogenicity study was conducted with smokeless tobacco using modern toxicological test methods and well-accepted standards. The study included a 1-year interim subgroup to assess toxicity at that intermediate time point. Test groups consisted of a tobacco blend (B) used in snus, and an aqueous tobacco extract of that tobacco blend (E) administered at 0.2, 2, or 5 mg nicotine/kg body weight/day via dosed feed to male and female Wistar Han rats...
October 2015: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/25839701/primary-mucinous-adenocarcinoma-of-the-epididymis-report-of-a-rare-case-with-molecular-genetic-characterization-including-mutation-analysis-of-the-tp53-gene
#9
Sarika Gupta, Benedict Yan, Pay Chin Leow, Sze Yung Chin, Richie Soong, Fredrik Petersson
We report a case of primary epididymal mucinous adenocarcinoma in a 60-year-old man who presented with a scrotal mass and subsequently developed pulmonary metastases. On immunohistochemistry the tumor was positive for villin and CK20 and negative for CK7, CDX2, and thyroid transcription factor-1. Molecular genetic analysis revealed an uncommon mutation; 249: AGG →ATG in the TP53 gene, which has not been previously described in association with a primary epididymal adenocarcinoma. Mutational analysis showed KRAS, BRAF, and VHL to be wild-type...
April 2015: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/25830704/brown-adipose-tissue-transplantation-reverses-obesity-in-ob-ob-mice
#10
Xiaomeng Liu, Siping Wang, Yilin You, Minghui Meng, Zongji Zheng, Meng Dong, Jun Lin, Qianwei Zhao, Chuanhai Zhang, Xiaoxue Yuan, Tao Hu, Lieqin Liu, Yuanyuan Huang, Lei Zhang, Dehua Wang, Jicheng Zhan, Hyuek Jong Lee, John R Speakman, Wanzhu Jin
Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted BAT from C57/BL6 mice into the dorsal subcutaneous region of age- and sex-matched leptin deficient Ob/Ob mice. Interestingly, BAT transplantation led to a significant reduction of body weight gain with increased oxygen consumption and decreased total body fat mass, resulting in improvement of insulin resistance and liver steatosis...
July 2015: Endocrinology
https://www.readbyqxmd.com/read/25821467/negative-energy-balance-induced-by-paradoxical-sleep-deprivation-causes-multicompartmental-changes-in-adipose-tissue-and-skeletal-muscle
#11
Marcos Mônico-Neto, Sara Quaglia de Campos Giampá, Kil Sun Lee, Camila Maria de Melo, Helton de Sá Souza, Murilo Dáttilo, Paulo Alexandre Minali, Pedro Henrique Santos Prado, Sergio Tufik, Marco Túlio de Mello, Hanna Karen Moreira Antunes
Objective. Describe multicompartmental changes in the fat and various muscle fiber types, as well as the hormonal profile and metabolic rate induced by SD in rats. Methods. Twenty adult male Wistar rats were equally distributed into two groups: experimental group (EG) and control group (CG). The EG was submitted to SD for 96 h. Blood levels of corticosterone (CORT), total testosterone (TESTO), insulin like growth factor-1 (IGF-1), and thyroid hormones (T3 and T4) were used to assess the catabolic environment...
2015: International Journal of Endocrinology
https://www.readbyqxmd.com/read/25590597/thyroid-stimulating-hormone-inhibits-adipose-triglyceride-lipase-in-3t3-l1-adipocytes-through-the-pka-pathway
#12
Dongqing Jiang, Shizhan Ma, Fei Jing, Chao Xu, Fang Yan, Aihong Wang, Jiajun Zhao
Thyroid-stimulating hormone (TSH) has been shown to play an important role in the regulation of triglyceride (TG) metabolism in adipose tissue. Adipose triglyceride lipase (ATGL) is a rate-limiting enzyme controlling the hydrolysis of TG. Thus far, it is unclear whether TSH has a direct effect on the expression of ATGL. Because TSH function is mediated through the TSH receptor (TSHR), TSHR knockout mice (Tshr-/- mice) (supplemented with thyroxine) were used in this study to determine the effects of TSHR deletion on ATGL expression...
2015: PloS One
https://www.readbyqxmd.com/read/25220112/experimentally-induced-hyperthyroidism-influences-oxidant-and-antioxidant-status-and-impairs-male-gonadal-functions-in-adult-rats
#13
M E Asker, W A Hassan, A M El-Kashlan
The objective of the present experiment was to study the effect of hyperthyroidism on male gonadal functions and oxidant/antioxidant biomarkers in testis of adult rats. Induction of hyperthyroidism by L-thyroxine (L-T4, 300 μg kg(-1) body weight) treatment once daily for 3 or 8 weeks caused a decrease in body weight gain as well as in absolute genital sex organs weight. The epididymal sperm counts and their motility were significantly decreased in a time-dependent manner following L-T4 treatment. Significant decline in serum levels of luteinising hormone, follicle stimulating hormone and testosterone along with significant increase in serum estradiol level was observed in hyperthyroid rats compared with euthyroid ones...
August 2015: Andrologia
https://www.readbyqxmd.com/read/25179371/municipal-landfill-leachate-induced-testicular-oxidative-damage-is-associated-with-biometal-accumulation-and-endocrine-disruption-in-rats
#14
Isaac A Adedara, Ifeoluwa O Awogbindin, Adebayo A Adesina, Oluwatosin O Oyebiyi, Tajudeen A Lawal, Ebenezer O Farombi
Improper management of hazardous wastes adversely impacts the environment and the public health. The present study was aimed at investigating the influence of Olushosun municipal landfill leachate (OMLL) from Ojota in the Lagos State of Nigeria on testicular function by assessing the plasma concentrations of reproductive hormones, testicular biometal levels, and antioxidant levels as well as observing the histological alterations in testes and epididymides of rats after exposure to 0, 12.5, and 25% OMLL in drinking water for 7 days...
January 2015: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/24079412/sperm-characteristics-antioxidant-status-and-hormonal-profile-in-rats-treated-with-artemisinin
#15
E O Farombi, I A Adedara, A O Abolaji, J P Anamelechi, J O Sangodele
The indiscriminate use, abuse and patients' noncompliance to normal prescription of artemisinin and its derivatives are a common practice during the treatment for drug-resistant malaria parasites in most developing countries. This study investigated the influence of artemisinin on the testicular and epididymal sperm antioxidant systems as well as on the plasma levels of hormones from the pituitary and thyroid components of the brain-pituitary-testicular axis. Oral exposure of rats to 0, 7 and 35 mg kg(-1) artemisinin for 7 days showed that the testicular antioxidant status at both therapeutic dose (7 mg kg(-1) ) and overdose (35 mg kg(-1) ), and the sperm antioxidant status at therapeutic dose of artemisinin remained unaffected compared with control...
October 2014: Andrologia
https://www.readbyqxmd.com/read/23762134/chinese-medicine-formula-lingguizhugan-decoction-improves-beta-oxidation-and-metabolism-of-fatty-acid-in-high-fat-diet-induced-rat-model-of-fatty-liver-disease
#16
Tao Liu, Li-Li Yang, Lu Zou, Dong-Fei Li, Hong-Zhu Wen, Pei-Yong Zheng, Lian-Jun Xing, Hai-Yan Song, Xu-Dong Tang, Guang Ji
Lingguizhugan decoction (LGZG), a classic traditional Chinese medicine (TCM) formula, has been used to treat obesity and hyperlipidemia in recent years, but the related mechanisms underlying the regulation of lipid metabolism by LGZG are not clear yet. Here, we reported the effectiveness and possible mechanisms of LGZG on rats with fatty liver disease induced by high-fat diet (HFD). Our results demonstrated that LGZG significantly attenuated HFD-induced fatty liver disease, as measured by body weight, liver index, epididymal fat pad-body weight ratio (EFP/BW), liver injury, and hepatic triglycerides (TG) probably through increasing serum thyroid hormone levels, improving beta-oxidation (via modulation of TR β 1 and CPT1A expression), metabolism and transport (through modulation of SREBP-1c, ACSL and ApoB100 expression) of fatty acid...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/23748362/diet-induced-obesity-increases-tumor-growth-and-promotes-anaplastic-change-in-thyroid-cancer-in-a-mouse-model
#17
Won Gu Kim, Jeong Won Park, Mark C Willingham, Sheue-yann Cheng
Recent epidemiological studies provide strong evidence suggesting obesity is a risk factor in several cancers, including thyroid cancer. However, the molecular mechanisms by which obesity increases the risk of thyroid cancer are poorly understood. In this study, we evaluated the effect of diet-induced obesity on thyroid carcinogenesis in a mouse model that spontaneously develops thyroid cancer (Thrb(PV/PV)Pten(+/-) mice). These mice harbor a mutated thyroid hormone receptor-β (denoted as PV) and haplodeficiency of the Pten gene...
August 2013: Endocrinology
https://www.readbyqxmd.com/read/22888365/antioxidant-and-protective-effects-of-bupleurum-falcatum-on-the-l-thyroxine-induced-hyperthyroidism-in-rats
#18
Seong-Mo Kim, Sang-Chan Kim, In-Kwon Chung, Woo-Hyun Cheon, Sae-Kwang Ku
Bupleuri Radix (BR), the dried roots of Bupleurum falcatum L., has been used in folk medicine as an antiinflammatory and antioxidative agent. The aqueous extract of BR was evaluated for its possible ameliorative effect in the regulation of hyperthyroidism in l-thyroxine- (LT4-) induced rat model. After oral administration of 300, 150, and 75 mg/kg of BR extracts, once a day for 15 days from 12th LT4 treatments, changes on the body, thyroid gland, liver, and epididymal fat pad weights, serum triiodothyronine, thyroxine, thyroid-stimulating hormone, asparte aminotransferase and alanine aminotransferase concentrations, hepatic lipid peroxidation, glutathione contents, superoxide dismutase, and catalase activities were investigated with thyroid gland, liver, and epididymal fat histopathological changes...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/22869001/the-hormonal-control-of-ejaculation
#19
REVIEW
Giovanni Corona, Emmanuele A Jannini, Linda Vignozzi, Giulia Rastrelli, Mario Maggi
Hormones regulate all aspects of male reproduction, from sperm production to sexual drive. Although emerging evidence from animal models and small clinical studies in humans clearly point to a role for several hormones in controlling the ejaculatory process, the exact endocrine mechanisms are unclear. Evidence shows that oxytocin is actively involved in regulating orgasm and ejaculation via peripheral, central and spinal mechanisms. Associations between delayed and premature ejaculation with hypothyroidism and hyperthyroidism, respectively, have also been extensively documented...
September 2012: Nature Reviews. Urology
https://www.readbyqxmd.com/read/22558148/the-impact-of-long-term-exposure-to-space-environment-on-adult-mammalian-organisms-a-study-on-mouse-thyroid-and-testis
#20
Maria Angela Masini, Elisabetta Albi, Cristina Barmo, Tommaso Bonfiglio, Lara Bruni, Laura Canesi, Samuela Cataldi, Francesco Curcio, Marta D'Amora, Ivana Ferri, Katsumasa Goto, Fuminori Kawano, Remo Lazzarini, Elisabetta Loreti, Naoya Nakai, Takashi Ohira, Yoshinobu Ohira, Silvio Palmero, Paola Prato, Franco Ricci, Linda Scarabelli, Tsubasa Shibaguchi, Renza Spelat, Felice Strollo, Francesco Saverio Ambesi-Impiombato
Hormonal changes in humans during spaceflight have been demonstrated but the underlying mechanisms are still unknown. To clarify this point thyroid and testis/epididymis, both regulated by anterior pituitary gland, have been analyzed on long-term space-exposed male C57BL/10 mice, either wild type or pleiotrophin transgenic, overexpressing osteoblast stimulating factor-1. Glands were submitted to morphological and functional analysis.In thyroids, volumetric ratios between thyrocytes and colloid were measured...
2012: PloS One
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