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Primary malignant bone tumors

Nicole E Smith-Guzmán, Jeffrey A Toretsky, Jason Tsai, Richard G Cooke
We present a rare case of primary bone cancer principally affecting the right humerus of a skeleton from the pre-Columbian site of Cerro Brujo (1265-1380 CE) in Bocas del Toro, on the Caribbean coast of Panamá, excavated in the early 1970s. The humerus contains a dense, calcified sclerotic mass with associated lytic lesions localized around the midshaft of the diaphysis. Evidence of systemic inflammation and anemia, likely caused by the cancer, are visible in the form of severe porotic hyperostosis of the cranial vault and bilateral periosteal reactions in the tibiae...
May 26, 2017: International Journal of Paleopathology
Osman Emre Aycan, Sami Sökücü, Devrim Özer, Engin Çetinkaya, Yavuz Arıkan, Yavuz Selim Kabukçuoğlu
OBJECTIVE: The aim of this study was to discuss the diagnosis and surgical management and their results according to stage of primary bone tumors at ulna and to share our experience on this exceptional location for bone tumors. METHODS: We have retrospectively reviewed our clinics database and identified 23 cases (14 males and 9 females, mean age was 28.9 (range 4-77)) with primary bone tumors and tumor like lesion involvement of ulna. The patients were evaluated according to complaints, type and grade of tumor, treatment, recurrence and functional status...
May 14, 2018: Acta Orthopaedica et Traumatologica Turcica
Z-H Jiao, J-D Wang, X-J Wang
OBJECTIVE:   Osteosarcoma is the most frequent primary bone malignancy that affects young adults and adolescents around the world. Increasing evidence suggests that dysfunctions of microRNAs (miRNAs) used to play an important role in human cancers. We aimed at evaluating the potential function of miR-16 and verify its influence on the function of RAB23 in osteosarcoma. PATIENTS AND METHODS: miR-16 expressions in osteosarcoma tissues and cell lines were examined using quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR)...
May 2018: European Review for Medical and Pharmacological Sciences
Brendan R Southam, Alvin H Crawford, David A Billmire, James Geller, Daniel Von Allmen, Adam P Schumaier, Sara Szabo
Adamantinoma is a rare, low-grade malignant tumor of the bone which grows slowly and typically occurs in the diaphysis of long bones, particularly in the tibia. Adamantinomas have the potential for local recurrence and may metastasize to the lungs, lymph nodes, or bone. We report a case of a 14-year-old female with a tibial adamantinoma who underwent wide resection with limb salvage and has subsequently been followed up for 18 years. The patient went on to have both a local soft tissue recurrence 5 years after the resection and metastases to both an inguinal lymph node and the right lower lobe of the lung 8 years after that recurrence, all of which have been treated successfully with marginal resections...
2018: Case Reports in Orthopedics
Soo Bin Park, Jung Mi Park, Seung Hwan Moon, Young Seok Cho, Jong-Mu Sun, Byung-Tae Kim, Kyung-Han Lee
BACKGROUND: When subjects without a known malignancy present with suspicious skeletal lesions, differential diagnosis and primary cancer identification is important. Here, we investigated the role of FDG PET/CT in this clinical situation. METHODS: We enrolled 103 patients with no known malignancies who were referred for FDG PET/CT because of bone lesions that were suspicious for cancer metastasis. Each extra-skeletal FDG lesion was categorized as consistent with primary cancer or with metastasis based on the distribution and pattern of all abnormal lesions in the individual...
2018: PloS One
Ming Qian, Haiyi Gong, Xinghai Yang, Jian Zhao, Wangjun Yan, Yan Lou, Dongyu Peng, Zhenxi Li, Jianru Xiao
Osteosarcoma (OS) is the most common type of primary bone tumor and accounts for ~60% of all malignant bone tumors in children and adolescents. A large number of studies have proposed that the dysregulated and dysfunctional microRNAs may serve important roles in the occurrence, progression and metastasis of various types of human cancer, including OS. MicroRNA-493 (miR-493) has been identified to act as a tumor suppressor in several types of human cancer. However, little is known regarding the expression pattern and clinical significance of miR-493 in OS...
May 2018: Oncology Letters
Chunming Jiang, Shenglin Ma, Runlei Hu, Xuepeng Wang, Maoqiang Li, Fei Tian, Wu Jiang, Liulong Zhu, Zhenyu Bian
BACKGROUND/AIMS: Osteosarcoma, the most common primary bone malignancy, arises from primitive transformed cells of mesenchymal origin with the worldwide increasing morbidity and mortality. Previous studies found apoptosis of osteosarcoma cells was essential for an effective manner to improve the progress of osteosarcoma, and CXCR4 has been demonstrated to be relevant with various tumor progress and metastasis. METHODS: The proliferation of cells transfected with CXCR4 shRNA and control shRNA were measured by BrdU assay...
May 3, 2018: Cellular Physiology and Biochemistry
Rafael De la Garza Ramos, Jonathan Nakhla, Murray Echt, Yaroslav Gelfand, David J Altschul, Woojin Cho, Merrit D Kinon, Reza Yassari
OBJECTIVE: To report the rate of bone morphogenetic protein-2 (BMP-2) use in vertebral column tumor surgery. METHODS: The Nationwide Inpatient Sample database (2012-2014) was queried to identify patients who underwent spinal fusion for vertebral column tumors (primary benign, primary malignant, or metastatic). The rate of BMP-2 use was calculated and patient/operative factors associated with its use were also investigated. RESULTS: A total of 9,375 patients who underwent fusion surgery for spinal tumors between 2012 and 2014 were identified, with 540 cases using BMP-2 (5...
May 4, 2018: World Neurosurgery
Tochukwu Ikpeze, Addisu Mesfin
Background: Chordomas are rare malignant primary tumors of the spine. In the mobile spine and sacrum an en-bloc resection is associated with decreased rates of recurrence. Our objective was to identify the top cited articles in chordoma research and to further analyze characteristics of these articles. Methods: In March 2017, we used ISI Web of Science (v5.11, Thomas Reuter, Philadelphia, Pennsylvania, USA) to search for the following key word: "chordoma"...
March 2018: Journal of Spine Surgery (Hong Kong)
Sheng Zhou, Min Xiong, Guo Dai, Ling Yu, Zhengpei Zhang, Jie Chen, Weichun Guo
Osteosarcoma is the most frequent primary malignant bone tumor. An increasing body of evidence has suggested that microRNAs (miRNA/miRs) have emerged as critical regulators in the initiation and progression of osteosarcoma. The present study explored the biological function of miR-192-5p and ubiquitin-specific protease 1 (USP1), and investigated whether miR-192-5p could directly interact with USP1 in osteosarcoma. The results revealed that miR-192-5p was significantly downregulated in osteosarcoma tissues and cell lines, while a reverse expression profile of USP1 was observed...
May 2018: Oncology Letters
Chen-Ming Su, Chih-Hsin Tang, Meng-Ju Chi, Chih-Yang Lin, Yi-Chin Fong, Yueh-Ching Liu, Wei-Cheng Chen, Shih-Wei Wang
Chondrosarcoma is a common primary malignant tumor of the bone that can metastasize through the vascular system to other organs. A key step in the metastatic process, lymphangiogenesis, involves vascular endothelial growth factor-C (VEGF-C). However, the effects of lymphangiogenesis in chondrosarcoma metastasis remain to be clarified. Accumulating evidence shows that resistin, a cytokine secreted from adipocytes and monocytes, also promotes tumor pathogenesis. Notably, chondrosarcoma can easily metastasize...
May 3, 2018: Biochemical Pharmacology
Abad Cherif El Asri, Mohamed Benzagmout, Khalid Chakour, Mohamed Faiz Chaoui, Jawad Laaguili, Chahdi Hafsa, Miloudi Gazzaz, Brahim El Mostarchid
BACKGROUND: Ewing's sarcoma (ES) is a malignant bone tumor that is most commonly observed in the long bones, the pelvis and in the chest. Primary intracranial localization is extremely rare. OBJECTIVE: In the aim of identifying the prognostic factors of this rare localization; we have conducted a systematic review of the literature for patients with primary intracranial pPNET/ES. METHODS: A complete MEDLINE search was undertaken for all articles reporting data for primary intracranaial pPNET/ES...
May 2, 2018: World Neurosurgery
A J Baños-Arévalo, N López-Navarro, E Gallego-Domínguez, E Herrera
Cutaneous metastases appear in 0.6% to 10.4% of malignant tumors and account for 2% of all cutaneous tumors. Metastasis to the skin may arise from progression of a known primary tumor or provide the first sign of an unsuspected one. Acral metastases are particularly unusual. Most derive from bone tumors. Clinical signs vary and the lesions generally resemble infection or inflammation, leading to diagnostic delays. When metástasis involves the fingers, the primary tumor is usually lung carcinoma. In contrast, toe involvement usually derives from a tumor in the genitourinary tract...
April 30, 2018: Actas Dermo-sifiliográficas
Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Yoshinobu Oka, Toshikazu Kubo
BACKGROUND: Ewing's sarcoma is a primary malignant tumor of bone occurring mostly in childhood. Few effective reconstruction techniques are available after wide resection of Ewing's sarcoma at the distal end of the tibia. Reconstruction after wide resection is especially difficult in children, as it is necessary to consider the growth and activity of the lower limbs. CASE PRESENTATION: A 12-year-old Japanese boy had presented with right lower leg pain at age 8 years...
May 2, 2018: BMC Cancer
Seckin Aydin, Odhan Yuksel, Rahime Tanritanir, Aysegul Esen Aydin, Suat Erol Celik
Ewing sarcoma is a rare primary malignant bone tumor which mainly effects children and adolescents. Calvarial bone involvement and its appearance in elder patients are extremely rare. We presented a 68 years old female patient with headache and right frontotemporal swelling. Imaging studies showed a right frontotemporal mass expanding to Sylvian fissure. The patient underwent total resection of the mass and pathological evaluation ensured the diagnosis of primary Ewing sarcoma. Patient had adjuvant radio- and chemotherapy after surgery...
April 28, 2018: World Neurosurgery
Vasiliki Apollonatou, Stelios Loukides, Andriana I Papaioannou, Spyros Papiris
We are presenting a case of acrometastasis in a male patient with lung adenocarcinoma. Acrometastases accumulate for 0.1% of all metastatic bone lesions and can be the first manifestation of cancer in approximately 10% of cases. The main clinical manifestations are tenderness, intermittent pain, functional impairment, erythema, heat and swelling of the affected part. Lung cancer is the main primary malignancy which causes acrometastases. Although the lesions can be recognized in x-rays or CT scans, the gold standard for the diagnosis is MRI scan in which the full extension of the tumor can be evaluated...
2018: Advances in Respiratory Medicine
Ferdinand Wagner, Boris M Holzapfel, Jacqui A McGovern, Abbas Shafiee, Jeremy G Baldwin, Laure C Martine, Christoph A Lahr, Felix M Wunner, Thor Friis, Onur Bas, Melanie Boxberg, Peter M Prodinger, Ali Shokoohmand, Davide Moi, Roberta Mazzieri, Daniela Loessner, Dietmar W Hutmacher
BACKGROUND: Existing preclinical murine models often fail to predict effects of anti-cancer drugs. In order to minimize interspecies-differences between murine hosts and human bone tumors of in vivo xenograft platforms, we tissue-engineered a novel orthotopic humanized bone model. METHODS: Orthotopic humanized tissue engineered bone constructs (ohTEBC) were fabricated by 3D printing of medical-grade polycaprolactone scaffolds, which were seeded with human osteoblasts and embedded within polyethylene glycol-based hydrogels containing human umbilical vein endothelial cells (HUVECs)...
July 2018: Biomaterials
Léa Plantureux, Lydie Crescence, Françoise Dignat-George, Laurence Panicot-Dubois, Christophe Dubois
Platelets are small (2-4 μm), anucleate, hematopoietic cells released by bone marrow megakaryocytes in the bloodstream. For a long time, platelets were described as the major effectors of hemostasis and thrombosis. In 1865, Armand Trousseau demonstrated a close relation between thrombosis and cancer. Subsequently, much clinical and experimental evidence supports the idea that platelets play several roles in the progression of malignancies and in cancer-associated thrombosis. In this review, we will discuss the roles of tumor-educated platelets (TEPs) in the progression of cancer from primary tumors to secondary metastatic outbreaks...
April 2018: Thrombosis Research
Qingping Zou, Xin Xiao, Ying Liang, Lina Peng, Zheng Guo, Wei Li, Wenqiang Yu
Osteosarcoma is a primary malignancy that develops in bone, along with serious recurrence and metastasis. As an isoform of Rho family GTPases, RhoB could suppress cell proliferation, invasion, and anti-angiogenesis. But it is not clear how RhoB involves in tumor metastasis. Here we found that expression of RhoB was decreased in osteosarcoma primary samples and cell lines. Ectopic expression of RhoB restrains the migration of osteosarcoma cells in vitro and in vivo, and induces osteosarcoma cell apopotsis. Further study showed that RhoB could interact with B55, increase the proportion of B55 in PP2A complex, and then enhance the dephosphorylation of AKT1...
April 24, 2018: Cancer Letters
Elena Nemecek, Philipp Theodor Funovics, Gerhard Martin Hobusch, Susanna Lang, Madeleine Willegger, Florian Sevelda, Thomas Brodowicz, Christoph Stihsen, Reinhard Windhager, Joannis Panotopoulos
Dedifferentiated chondrosarcoma is a rare primary bone malignancy with a very poor prognosis. The aim of the study was to identify pretreatment serum markers as prognostic factors for the overall survival (OS) of patients with dedifferentiated chondrosarcoma. We retrospectively reviewed 33 patients with histologically confirmed dedifferentiated chondrosarcoma treated at our department from 1977 to 2015. Kaplan-Meier estimation, uni- and multivariable Cox proportional hazard model were performed to evaluate the association between serum markers such as the C-reactive protein and OS...
April 27, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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