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https://www.readbyqxmd.com/read/28906396/chondrosarcoma-of-the-patella-a-case-report
#1
Conglin Ye, Zhiping Luo, Jin Zeng, Min Dai
RATIONALE: Chondrosarcoma, characterized by the production of cartilage matrix, is a common bone tumor, accounting for 20% to 27% of all malignant bone tumors. It often occurs in the cartilage of the pelvis, femur, tibia, and humerus. However, chondrosarcoma of the patella is extremely rare. PATIENT CONCERNS: The present study describes a case of chondrosarcoma affecting the right patella in a 68-year-old woman. The chief complaints were painful swelling and limitation of motion of the right knee for about half a year...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28904574/multicentric-chordoma-in-a-child
#2
Shighakolli Ramesh, Raju Subodh, Srinadh Boppana, Erukkambattu Jayashankar
Chordomas are primary malignant bone tumors that arise in the axial skeleton, believed to originate from remnants of embryologic notochordal cell rests. Multicentric origin of chordoma is extremely rare. To our literature search, we found only three cases of multicentric chordoma in adults. We report a first case of multicentric chordoma in pediatric age group. A 14-month-old child presented with torticolis and left upper limb monoparesis, imaging showed expansile bony destructive lesion in clivus and dorsal spine simultaneously...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28900835/osteitis-fibrosa-cystica-a-forgotten-radiological-feature-of-primary-hyperparathyroidism
#3
Waldemar Misiorowski, Izabela Czajka-Oraniec, Magdalena Kochman, Wojciech Zgliczyński, John P Bilezikian
Although bone disease and stone disease are the universally accepted classical manifestations of primary hyperparathyroidism, clinical parathyroid bone disease is rarely seen today in the United States (<5% of patients) and Western Europe. Nevertheless, in a given patient, classical skeletal involvement can be the first sign of primary hyperparathyroidism, but not recognized because it is not usually included, anymore, in the differential diagnosis of this manifestation of skeletal disease. We describe four cases of primary hyperparathyroidism in which the first clinical manifestation of the disease was a pathological fracture that masqueraded as a malignancy...
September 12, 2017: Endocrine
https://www.readbyqxmd.com/read/28900340/primary-intraosseous-malignant-peripheral-nerve-sheath-tumor-of-metacarpal-bones-of-the-hand-in-a-patient-without-neurofibromatosis-1-report-of-a-rare-case
#4
Bharti Devnani, Ahitagni Biswas, Sameer Bakhshi, Shah Alam Khan, Asit Ranjan Mridha, Shipra Agarwal
Malignant peripheral nerve sheath tumor (MPNST) usually arises in peripheral nerve sheath cells. The intraosseous location of MPNST is rare. Mandible is the most common site of bony involvement. Involvement of bones of the hand is quite unusual. We report a case of MPNST involving metacarpal bones of the left hand treated with surgery followed by adjuvant radiation and chemotherapy and review the pertinent literature.
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28899740/histone-3-3-mutations-in-giant-cell-tumor-and-giant-cell-rich-sarcomas-of-bone
#5
Alberto Righi, Irene Mancini, Marco Gambarotti, Piero Picci, Gabriella Gamberi, Cristina Marraccini, Angelo Paolo Dei Tos, Lisa Simi, Pamela Pinzani, Alessandro Franchi
Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. While over 90% of GCTB presents histone 3.3 variants exclusively in the H3F3A gene, chondroblastoma is mutated mainly in H3F3B. In this study we examined a series of giant cell rich primary bone tumors, aiming to evaluate the possible diagnostic role of histone 3.3 mutations in the differential diagnosis between GCTB and giant cell rich sarcomas...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28895084/the-oncologic-impact-of-postoperative-complications-following-resection-of-truncal-and-extremity-soft-tissue-sarcomas
#6
Justine S Broecker, Cecilia G Ethun, David K Monson, Alexandra G Lopez-Aguiar, Nina Le, Mia McInnis, Karen Godette, Nickolas B Reimer, Shervin V Oskouei, Keith A Delman, Charles A Staley, Shishir K Maithel, Kenneth Cardona
INTRODUCTION: Postoperative complications (POCs) negatively impact oncologic outcomes in some malignancies; however, little is known regarding their effect in soft tissue sarcoma (STS). The aim of this study was to determine the impact of POCs on survival after resection of truncal and extremity STS. METHODS: All patients who underwent resection for a primary truncal or extremity STS at a single academic institution from 2000 to 2015 were included and analyzed. Primary outcome was disease-specific survival (DSS)...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28889371/bone-marrow-stroma-and-vascular-contributions-to-myeloma-bone-homing
#7
REVIEW
Michele Moschetta, Yawara Kawano, Antonio Sacco, Angelo Belotti, Rossella Ribolla, Marco Chiarini, Viviana Giustini, Diego Bertoli, Alessandra Sottini, Monica Valotti, Claudia Ghidini, Federico Serana, Michele Malagola, Luisa Imberti, Domenico Russo, Alessandro Montanelli, Giuseppe Rossi, Michaela R Reagan, Patricia Maiso, Bruno Paiva, Irene M Ghobrial, Aldo M Roccaro
PURPOSE OF THE REVIEW: Herein we dissect mechanisms behind the dissemination of cancer cells from primary tumor site to the bone marrow, which are necessary for metastasis development, with a specific focus on multiple myeloma. RECENT FINDINGS: The ability of tumor cells to invade vessels and reach the systemic circulation is a fundamental process for metastasis development; however, the interaction between clonal cells and the surrounding microenvironment is equally important for supporting colonization, survival, and growth in the secondary sites of dissemination...
September 9, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28882648/mir-598-a-tumor-suppressor-with-biomarker-significance-in-osteosarcoma
#8
Kai Liu, Xiaolu Sun, Yingang Zhang, Liang Liu, Qiling Yuan
AIMS: Osteosarcoma is the most frequent primary malignant bone tumor in children and adolescents. Identifying specific and sensitive biomarkers is beneficial to early detection and improvement of life qualities and overall survival rates of osteosarcoma patients. MATERIALS AND METHODS: Realtime PCR was used to detect the expression of miR-598. CCK-8 assay was employed to detect the proliferation of osteosarcoma cells, while transwell assays were used to examine the migration and invasion...
September 4, 2017: Life Sciences
https://www.readbyqxmd.com/read/28881805/down-regulation-of-human-positive-coactivator-4-suppress-tumorigenesis-and-lung-metastasis-of-osteosarcoma
#9
Xu Hu, Chao Zhang, Ying Zhang, Christopher S Hong, Wugui Chen, Weiwei Shen, Hongkai Wang, Jianrong He, Pei Chen, Yue Zhou, Chunmeng Shi, Tongwei Chu
Osteosarcoma is a kind of primary malignant bone tumor with the highest incidence and an extraordinarily poor prognosis and early pulmonary metastasis formation as a frequent occurrence. Transcriptional positive coactivator 4 (PC4) has multiple functions in DNA replication, transcription, repair and chromatin organization, even in tumorigenesis. However, the precise function of PC4 in osteosarcoma is still unclear and controversial. In this paper we found PC4 was upregulated in patient-derived osteosarcoma tissues compared to normal...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28876452/management-of-primary-malignant-bone-and-soft-tissue-tumors-of-foot-and-ankle-is-it-worth-salvaging
#10
Harzem Özger, Buğra Alpan, Osman Emre Aycan, Natig Valiyev, Mustafa Çağlar Kir, Fulya Ağaoğlu
BACKGROUND AND OBJECTIVE: Performing limb salvage with safe margins and preserving meaningful function is very difficult in the setting of primary malignant bone and soft tissue tumors due to the complex and constrained anatomy of the foot and ankle. The study aims to evaluate the efficacy of limb salvage procedures in terms of functional and oncological outcomes. METHODS: Clinical data of 48 patients, who underwent surgical treatment between 1992 and 2015 in our institution, were retrospectively analyzed...
September 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28875280/metastases-to-the-parathyroid-glands-a-comprehensive-literature-review-of-127-reported-cases
#11
REVIEW
Justin L Bauer, Sherwin Toluie, Lester D R Thompson
Metastases to the head and neck organs are uncommon, potentially representing the initial presentation of an occult malignancy. Single case reports and small series report metastases to the parathyroid gland, but there is no large review of the literature on secondary tumors involving the parathyroid glands. A review of the English literature between 1950 and 2017 was performed of all metastases or secondary involvement of the parathyroid glands. One hundred and twenty-seven cases of metastatic tumors were reported, although potentially significantly unrepresented in autopsy series (parathyroid glands are not routinely examined) and due to reporting bias...
September 5, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28862793/fine-needle-aspiration-biopsy-of-lytic-bone-lesions-an-institution-s-experience
#12
Uday Shergill, Taisia Vitkovski, Guillaume Stoffels, Melissa Klein, Cecilia Gimenez, Alice Laser, Rubina Cocker, Karen Chau, Kasturi Das
OBJECTIVES: Fine needle aspiration (FNAB) is an effective, minimally-invasive, inexpensive, diagnostic technique. The objective of this study was to evaluate the accuracy of FNAB in the diagnosis of bone lesions. METHODS: FNABs of bone lesions diagnosed at our institution over a 2-year period were retrospectively analyzed. RESULTS: 241 samples were reviewed. Patients included 121 males and 120 females, with ages ranging from 4-95 years (mean = 66 years)...
September 1, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28855991/primary-malignant-lymphoma-of-the-talus-a-case-report-and-review-of-the-literature
#13
Shunsuke Sato, Yoichi Kaneuchi, Michiyuki Hakozaki, Hitoshi Yamada, Satoshi Kawana, Osamu Hasegawa, Shinichi Konno
Malignant lymphoma commonly occurs in adults, with a peak incidence between the seventh and ninth decades of life. Although malignant lymphoma usually occurs in the lymph nodes, it rarely occurs primarily in the bone. We herein describe an extremely rare case of primary malignant lymphoma of the talus in a 74-year-old man. Although plain radiographs showed no abnormality, gadolinium-enhanced magnetic resonance imaging (MRI) revealed a well-circumscribed intra- and extraosseous tumor of the talus. (18)F-fluorodeoxyglucose (FDG) positron emission tomography/MRI revealed a marked increase of FDG uptake in the right ankle and the right inguinal lymph nodes...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28853064/receptor-activator-of-nuclear-transcription-factor-nf-%C3%AE%C2%BAb-rank-its-ligand-rankl-and-natural-inhibitor-of-rankl-osteoprotegerin-opg-in-the-blood-serum-of-patients-with-primary-bone-tumors
#14
N E Kushlinskii, E S Gershtein, Yu N Solov'ev, Yu S Timofeev, I V Babkina, A O Dolinkin, A A Zuev, O I Kostyleva
The content of components of the RANK/RANKL/OPG system, the key regulator of homeostasis in the bone tissue, in blood serum samples from 199 patients with primary bone neoplasms and 131 practically healthy volunteers was measured by ELISA. Borderline giantcell tumor of the bone with high osteoclastogenic and osteolytic activity is characterized by an increase in the level of all components of this system and highest ratio of sRANKL/OPG in the blood serum. Study indexes in patients with various benign neoplasms and tumor-like bone lesions were lower than in patients with giant-cell tumor...
August 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28844303/calcaneal-ewing-s-sarcoma-with-skip-metastases-to-tarsals-and-lymph-node-involvement-a-case-report
#15
Koray Şahin, Serkan Bayram, Ahmet Salduz
Ewing's sarcoma (ES) represents the second most common primary malignant tumor of bone of children and occurs rarely in the bones of the foot. Dissemination to regional lymph nodes and skip metastases to adjacent bones are thought to be uncommon. We report a case of a 19-year-old female with the diagnosis of ES of the right calcaneus. Six months earlier, she had presented to the hospital with a history of ankle sprain and was treated with analgesics and ice application. Despite the treatment, the pain over the ankle persisted, her foot swelled progressively, and a mass evolved on the lateral side of the foot...
August 22, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28828045/giant-cell-tumor-of-long-bones-outcomes-of-treatment-corelating-with-histopathological-grade
#16
Gabriel Stan, Horia Orban, Nicolae Gheorghiu
INTRODUCTION: Giant cell tumor (GCT) of bone is a borderline lesion of bones, meaning that in certain conditions it could be transforming in malignant tumor. This article describes the clinical outcome of patients with giant cell tumor of bone and discusses the surgical options for this lesion corelating with histopathological grade. MATERIAL AND METHODS: From 2007 to 2015, 15 patients who met the histological criteria of giant cell tumor of bone were treated at our institution...
December 2016: Mædica
https://www.readbyqxmd.com/read/28819506/-parathyroid-carcinoma-about-a-case-and-review-of-the-literature
#17
REVIEW
Naourez Kolsi, Sondos Jellali, Jamel Koubaa
Parathyroid carcinoma is a very rare malignant tumor of the parathyroid gland. Clinically, this cancer is characterized by the presence of severe primary hyperparathyroidism. Diagnosis is based on histological examination but is not always easy. Surgery is the treatment of choice. We report the case of a 59-year old woman with a personal history of arterial hypertension and of recurrent renal lithiasis, presenting with diffuse bone pain associated with asthenia. Neck examination showed hard basi-cervical swelling with nonpalpable lower edge...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28815357/carbon-fiber-reinforced-peek-fixation-system-in-the-treatment-of-spine-tumors-a-preliminary-report
#18
Stefano Boriani, Giuseppe Tedesco, Lu Ming, Riccardo Ghermandi, Maurizio Amichetti, Piero Fossati, Marco Krengli, Loredana Mavilla, Alessandro Gasbarrini
BACKGROUND: Protocols including combination of surgery and radiotherapy are more and more frequent in the treatment of bone tumors of the spine. In metastatic disease, combination of surgery and radiotherapy is since long time accepted, as based on clinical evidence. In primary tumors, combination of surgery and radiotherapy can be considered in all the cases in which a satisfactory oncological margin cannot be achieved: high-grade malignancies, recurrent tumors, huge tumors expanding in an extracompartimental area, and when tumor-free margin requires unacceptable functional sacrifices...
August 16, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28799812/high-prevalence-of-vitamin-d-deficiency-in-patients-with-bone-tumors
#19
Konstantin Horas, Gerrit Maier, Franz Jakob, Uwe Maus, Andreas Kurth, Axel Jakuscheit, Maximilian Rudert, Boris Michael Holzapfel
The aim of this study was to evaluate the prevalence of vitamin D deficiency in patients with different types of bone tumors and to elucidate whether or not there are differences in prediagnostic vitamin D levels in patients with malignant compared to benign bone tumors. Prediagnostic serum 25(OH)D levels of 105 consecutive patients that presented with bone tumors and tumor-like lesions to two Orthopedic Level I University Centers in Germany between 2011 and 2016 were measured on admission. We found an alarming and widespread rate of vitamin D deficiency in patients with bone tumors...
August 11, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28799237/anticancer-efficacy-of-the-hypoxia-activated-prodrug-evofosfamide-is-enhanced-in-combination-with-proapoptotic-receptor-agonists-against-osteosarcoma
#20
Vasilios Liapis, Aneta Zysk, Mark DeNichilo, Irene Zinonos, Shelley Hay, Vasilios Panagopoulos, Alexandra Shoubridge, Christopher Difelice, Vladimir Ponomarev, Wendy Ingman, Gerald J Atkins, David M Findlay, Andrew C W Zannettino, Andreas Evdokiou
Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, hypoxia also leads to treatment opportunities as demonstrated by the development of compounds that target regions of hypoxia within tumors. Evofosfamide is a hypoxia-activated prodrug that is created by linking the hypoxia-seeking 2-nitroimidazole moiety to the cytotoxic bromo-isophosphoramide mustard (Br-IPM). When evofosfamide is delivered to hypoxic regions of tumors, the DNA cross-linking toxin, Br-IPM, is released leading to cell death...
August 10, 2017: Cancer Medicine
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