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Traumatic brain injury concussion

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https://www.readbyqxmd.com/read/28326890/functional-and-molecular-correlates-following-single-and-repeated-rat-closed-head-concussion-indices-of-vulnerability-following-brain-injury
#1
Andrea Mountney, Angela Boutte, Casandra M Cartagena, William J Flerlage, David Johnson, Chanyang Rho, Xi-Chun M Lu, Angela M Yarnell, Sean R Marcsisin, Jason Sousa, Chau Vuong, Victor E Zottig, Lai Yee Leung, Ying Deng-Bryant, Janice Gilsdorf, Frank C Tortella, Deborah A Shear
Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). Isolated concussions frequently produce acute neurological impairments; however, individuals typically recover spontaneously within a short time frame. In contrast, brain injuries resulting from multiple concussions can result in cumulative damage and elevated risk of developing chronic brain pathologies, including chronic traumatic encephalopathy (CTE). Increased attention has focused on identification of diagnostic markers that can prognostically serve as indices of brain health after injury, revealing the temporal profile of vulnerability to a second insult...
March 22, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28324787/interactive-ebooks-in-educating-patients-and-their-families-about-head-injury-regardless-of-age
#2
Ronald Sahyouni, Amin Mahmoodi, Amir Mahmoodi, Melissa Huang, Diem Kieu Tran, Jefferson W Chen
OBJECTIVES: Traumatic Brain Injury (TBI) is a common and debilitating injury that is particularly prevalent in patients over 60. Given the influence of head injury on dementia (and vice versa), and the increased likelihood of ground-level falls, elderly patients are vulnerable to TBI. Educational interventions can increase knowledge and influence preventative activity to decrease the likelihood of further TBI. We sought to determine the efficacy of interactive tablet-based educational interventions in elderly patients on self-reported knowledge...
March 8, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28314862/epidemiology-and-prognosis-of-mild-traumatic-brain-injury-in-returning-soldiers-a-cohort-study
#3
Karen Schwab, Heidi P Terrio, Lisa A Brenner, Renee M Pazdan, Henry P McMillan, Margaret MacDonald, Sidney R Hinds, Ann I Scher
OBJECTIVE: Mild traumatic brain injury (mTBI; concussion) is common in returning service members yet limited definitive evidence exists on its prognosis. METHODS: Almost 25,000 non-medically evacuated soldiers returning from Afghanistan or Iraq to 2 military bases between 2009 and 2014 were screened for mTBI. We invited a random sample to participate in the present study, oversampling those screening positive, resulting in 557 mTBI cases and 1,010 controls, of whom 366 cases and 599 controls completed 3-month follow-up evaluations...
March 17, 2017: Neurology
https://www.readbyqxmd.com/read/28301824/using-a-dual-task-protocol-to-investigate-motor-and-cognitive-performance-in-healthy-children-and-youth
#4
Tracy L Fabri, Katherine E Wilson, Nicole Holland, Andrea Hickling, James Murphy, Philippe Fait, Nick Reed
OBJECTIVES: Mild traumatic brain injury (or concussion) is a prevalent yet understudied health concern in children and youth. This injury can cause dysfunction in both motor and cognitive domains; however, most literature focuses on single-task neuropsychological tests which only assess cognition. Although dual-task research on concussed children and youth is needed as many daily activities require both motor and cognitive domains, we must first investigate whether performing simultaneous motor and cognitive tasks of varied complexity impact these domains in healthy children and youth...
March 6, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28301451/traumatic-brain-injury-related-emergency-department-visits-hospitalizations-and-deaths-united-states-2007-and-2013
#5
Christopher A Taylor, Jeneita M Bell, Matthew J Breiding, Likang Xu
PROBLEM/CONDITION: Traumatic brain injury (TBI) has short- and long-term adverse clinical outcomes, including death and disability. TBI can be caused by a number of principal mechanisms, including motor-vehicle crashes, falls, and assaults. This report describes the estimated incidence of TBI-related emergency department (ED) visits, hospitalizations, and deaths during 2013 and makes comparisons to similar estimates from 2007. REPORTING PERIOD: 2007 and 2013. DESCRIPTION OF SYSTEM: State-based administrative health care data were used to calculate estimates of TBI-related ED visits and hospitalizations by principal mechanism of injury, age group, sex, and injury intent...
March 17, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28298170/concussion-induces-hippocampal-circuitry-disruption-in-swine
#6
John A Wolf, Brian N Johnson, Victoria E Johnson, Mary E Putt, Kevin D Browne, Constance J Mietus, Daniel P Brown, Kathryn L Wofford, Douglas H Smith, M Sean Grady, Akiva S Cohen, D Kacy Cullen
Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI), however the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following TBI using a model of head rotational acceleration that closely replicates the biomechanics and neuropathology of closed-head TBI in humans. We examined neurophysiological changes using a novel ex vivo hippocampal slice paradigm with extracellular stimulation and recording in the dentate gyrus and CA1 occurring at 7 days following non-impact inertial TBI in swine...
March 16, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28296510/multidisciplinary-outpatient-treatment-in-patients-with-mild-traumatic-brain-injury-a-randomised-controlled-intervention-study
#7
Eirik Vikane, Torgeir Hellstrøm, Cecilie Røe, Erik Bautz-Holter, Jörg Aßmus, Jan Sture Skouen
OBJECTIVE: To evaluate the efficacy of a multidisciplinary outpatient follow-up programme compared to follow-up by a general practitioner for patients being at-risk or sick-listed with persistent post-concussion symptoms two months after a mild traumatic brain injury. DESIGN: Randomised controlled trial. PATIENTS: One hundred fifty-one patients, 16-56 years. METHODS: Multidisciplinary outpatient rehabilitation with individual contacts and a psycho-educational group intervention at two outpatient rehabilitation clinics compared to follow-up by a general practitioner after the multidisciplinary examination...
March 15, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28287287/reporting-of-symptoms-associated-with-concussion-by-oef-oif-ond-veterans-comparison-between-research-and-clinical-contexts
#8
Colleen E Jackson, Leslie Nordstrom, Jennifer R Fonda, Catherine B Fortier, William P Milberg, Regina E McGlinchey
OBJECTIVE: Veterans from recent military conflicts frequently report persisting symptoms associated with concussion well beyond the expected period of recovery following mild traumatic brain injury. This study examined differences in the reporting of symptoms associated with concussion between clinical and research contexts. METHODS: This naturalistic comparison included 91 Veterans from Operations Enduring Freedom (OEF), Iraqi Freedom (OIF) and New Dawn (OND). All participants were enrolled in a longitudinal study focused on traumatic brain injury and stress-related disorders and had also completed a VHA Comprehensive TBI Evaluation...
March 13, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28285252/anxiety-sensitivity-mediates-gender-differences-in-post-concussive-symptoms-in-a-clinical-sample
#9
Brian J Albanese, Joseph W Boffa, Richard J Macatee, Norman B Schmidt
Traumatic brain injury (TBI) is both prevalent and potentially disabling. Extant literature has demonstrated women to report greater post-concussive symptoms (PCS) compared to men, highlighting the necessity of investigations into malleable, gender-linked risk factors for PCS that hold promise for reducing this gender disparity. Anxiety Sensitivity (AS) and Distress Tolerance (DT) are gender-linked risk factors that may be related to PCS. Despite a breadth of research supporting elevated AS and reduced DT in women, no study to date has investigated whether AS and DT mediate gender differences in PCS...
March 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28283595/astroglial-activation-and-altered-amyloid-metabolism-in-human-repetitive-concussion
#10
Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kina Höglund, Erik Portelius, David L Brody, Kaj Blennow, Henrik Zetterberg
OBJECTIVE: To determine whether postconcussion syndrome (PCS) due to repetitive concussive traumatic brain injury (rcTBI) is associated with CSF biomarker evidence of astroglial activation, amyloid deposition, and blood-brain barrier (BBB) impairment. METHODS: A total of 47 participants (28 professional athletes with PCS and 19 controls) were assessed with lumbar puncture (median 1.5 years, range 0.25-12 years after last concussion), standard MRI of the brain, and Rivermead Post-Concussion Symptoms Questionnaire (RPQ)...
March 10, 2017: Neurology
https://www.readbyqxmd.com/read/28281095/a-national-study-on-the-effects-of-concussion-in-collegiate-athletes-and-us-military-service-academy-members-the-ncaa-dod-concussion-assessment-research-and-education-care-consortium-structure-and-methods
#11
Steven P Broglio, Michael McCrea, Thomas McAllister, Jaroslaw Harezlak, Barry Katz, Dallas Hack, Brian Hainline
BACKGROUND: The natural history of mild traumatic brain injury (TBI) or concussion remains poorly defined and no objective biomarker of physiological recovery exists for clinical use. The National Collegiate Athletic Association (NCAA) and the US Department of Defense (DoD) established the Concussion Assessment, Research and Education (CARE) Consortium to study the natural history of clinical and neurobiological recovery after concussion in the service of improved injury prevention, safety and medical care for student-athletes and military personnel...
March 9, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28269244/portable-video-oculography-device-for-implementation-in-sideline-concussion-assessments-a-prototype
#12
Joshua D Fischer, Dawie J van den Heever
Concussion is currently a serious health problem and can lead to severe brain dysfunction. There is a definite need for sensitive and reliable tests to detect and evaluate the subtle changes in brain function caused by concussion. This study details the development of a low cost portable eye tracking device that can aid in the detection of concussions. The device evaluates ocular motor function and can be used on the sidelines of sporting events to give a quick indication of the severity of head trauma. It can further be used to evaluate and monitor mild Traumatic Brain Injuries and aid in the return to play decision making process...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28250556/cascade-of-traumatic-brain-injury-a-correlational-study-of-cognition-postconcussion-symptoms-and-quality-of-life
#13
Rajakumari Pampa Reddy, Jamuna Rajeswaran, B Indira Devi, Thennarasu Kandavel
INTRODUCTION: Traumatic brain injury (TBI) constitutes a significant burden on health care resources in India. TBI is a dynamic process which involves damage to the brain thus leading to behavior cognitive and emotional consequences. AIM: To study the cognitive profile, post-concussion symptoms (PCS), quality of life (QOL), and their correlation. METHODS: A total of 60 patients with TBI were recruited and assessed for neuropsychological profile, PCS, and QOL, the correlation among the variables were analyzed...
January 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28245607/increased-risk-of-stroke-in-patients-of-concussion-a-nationwide-cohort-study
#14
Shih-Wei Liu, Liang-Chung Huang, Wu-Fu Chung, Hsuan-Kan Chang, Jau-Ching Wu, Li-Fu Chen, Yu-Chun Chen, Wen-Cheng Huang, Henrich Cheng, Su-Shun Lo
Long-term morbidities can develop after traumatic brain injury (TBI). Some studies have suggested that the risk of stroke is higher after TBI, but the association between concussion and stroke remains unclear. Using a national cohort, the authors analyzed the incidence of both hemorrhagic and ischemic strokes in patients with previous concussion. A representative cohort of approximately one million people was followed up for four years. Patients with new-onset concussion were identified (n = 13,652) as the concussion group...
February 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28243574/5-year-imaging-sequelae-of-concussive-blast-injury-and-relation-to-early-clinical-outcome
#15
Christine L Mac Donald, Jason Barber, Jalal Andre, Nicole Evans, Chris Panks, Samantha Sun, Kody Zalewski, R Elizabeth Sanders, Nancy Temkin
Current imaging diagnostic techniques are often insensitive to the underlying pathological changes following mild traumatic brain injury (TBI) or concussion so much so that the explicit definition of these uncomplicated mild brain injuries includes the absence of radiological findings. In the US military, this is complicated by the natural tendency of service members to down play symptoms for fear of removal from their unit particularly in combat making it challenging for clinicians to definitively diagnose and determine course of treatment...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28239838/which-matters-more-a-retrospective-cohort-study-of-headache-characteristics-and-diagnosis-type-in-soldiers-with-mtbi-concussion
#16
Alan G Finkel, Brian J Ivins, Juanita A Yerry, John S Klaric, Ann Scher, Y Sammy Choi
OBJECTIVE: To describe the diagnostic types and characteristics of headaches in soldiers with mild traumatic brain injury during the wars in Afghanistan and Iraq. BACKGROUND: Persistent post-traumatic headache interferes with returns to activity or duty. The most commonly cited headache diagnosis after concussion is migraine. We hypothesize that headache diagnosis type, eg, migraine, is not sufficient to predict relationships with occupational outcomes after concussion...
February 27, 2017: Headache
https://www.readbyqxmd.com/read/28228694/survey-of-primary-contact-medical-and-chiropractic-clinicians-on-self-reported-knowledge-and-recognition-of-mild-traumatic-brain-injuries-a-pilot-study
#17
David N Taylor, Frank J Ponce, Stephen J Dyess
OBJECTIVE: The purpose of this study was to assess the self-reported knowledge of concussion recognition and treatment with first-contact family medical and chiropractic practitioners by means of a pilot study of the need, construct validity, and feasibility for further investigation of mild traumatic brain injury (MTBI) knowledge base. METHODS: Two hundred forty-eight practicing chiropractic and 120 medical physicians in the south and northeastern sections of the United States were contacted by e-mail, telephone, and postal mail to answer an 18-item survey on knowledge, diagnosis, and common practice with respect to traumatic brain injury patients...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28227478/portable-video-oculography-device-for-implementation-in-sideline-concussion-assessments-a-prototype
#18
Joshua D Fischer, Dawie J van den Heever, Joshua D Fischer, Dawie J van den Heever, Dawie J Van den Heever, Joshua D Fischer
Concussion is currently a serious health problem and can lead to severe brain dysfunction. There is a definite need for sensitive and reliable tests to detect and evaluate the subtle changes in brain function caused by concussion. This study details the development of a low cost portable eye tracking device that can aid in the detection of concussions. The device evaluates ocular motor function and can be used on the sidelines of sporting events to give a quick indication of the severity of head trauma. It can further be used to evaluate and monitor mild Traumatic Brain Injuries and aid in the return to play decision making process...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222567/immune-biomarkers-for-the-diagnosis-of-mild-traumatic-brain-injury
#19
Ashley B Petrone, Valerie Gionis, Richard Giersch, Taura L Barr
BACKGROUND: In 2010, there were approximately 2.2 million emergency room visits associated with traumatic brain injury (TBI), with 80 percent diagnosed as mild TBI or concussion. In addition, there are a large number of TBIs, especially mild TBIs, which go either unreported by patients or initially undiagnosed by clinicians. Our team has previously identified a panel of immune-related genes that can diagnose ischemic stroke at triage, and due to shared pathophysiological mechanisms of TBI and stroke, we hypothesized that this panel of genes may also be utilized for the diagnosis of TBI...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28217290/neuroprotective-effect-of-hyperbaric-oxygen-therapy-in-a-juvenile-rat-model-of-repetitive-mild-traumatic-brain-injury
#20
Lei Huang, Andre Obenaus, Mary Hamer, John H Zhang
Repetitive mild traumatic brain injury (rmTBI) is an important medical concern for adolescent athletes that can lead to long-term disabilities. Multiple mild injuries may exacerbate tissue damage resulting in cumulative brain injury and poor functional recovery. In the present study, we investigated the increased brain vulnerability to rmTBI and the effect of hyperbaric oxygen treatment using a juvenile rat model of rmTBI. Two episodes of mild cortical controlled impact (3 days apart) were induced in juvenile rats...
October 2016: Medical Gas Research
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