keyword
MENU ▼
Read by QxMD icon Read
search

Alkaline phosphatase high

keyword
https://www.readbyqxmd.com/read/29050431/a-study-on-the-sternum-growth-and-mineralization-kinetic-of-meat-duck-from-35-to-63-days-of-age
#1
H Y Zhang, H Liao, Q F Zeng, J P Wang, X M Ding, S P Bai, K Y Zhang
The sternum as an important part of the skeleton and not only provides a crucial attachment site for the pectoral muscles and protects internal organs such as the heart and lungs for meat duck, but may also be considered as the primary ventilator in the avian respiratory system. Therefore, this study focuses on the sternum growth and mineralization kinetics of ducks from 35 d to 63 d of age. A total of 72 one-d-old males and 72 females were chosen and fed with the same diet until the age of 9 weeks. The sternum and serum were harvested at 35 d, 42 d, 49 d, 56d, and 63 d of feeding...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29045803/chitosan-based-trilayer-scaffold-for-multitissue-periodontal-regeneration
#2
E M Varoni, S Vijayakumar, E Canciani, A Cochis, L De Nardo, G Lodi, L Rimondini, M Cerruti
Periodontal regeneration is still a challenge for periodontists and tissue engineers, as it requires the simultaneous restoration of different tissues-namely, cementum, gingiva, bone, and periodontal ligament (PDL). Here, we synthetized a chitosan (CH)-based trilayer porous scaffold to achieve periodontal regeneration driven by multitissue simultaneous healing. We produced 2 porous compartments for bone and gingiva regeneration by cross-linking with genipin either medium molecular weight (MMW) or low molecular weight (LMW) CH and freeze-drying the resulting scaffolds...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29043874/the-risk-of-occupational-exposure-to-mercury-vapor-in-some-public-dental-clinics-of-baghdad-city-iraq
#3
Enas Sultan Al-Zubaidi, Adel Mashaan Rabee
BACKGROUND: Dental workers are exposed to elevated levels of elemental mercury vapor substantially above the occupational exposure standards when placing or removing mercury/silver tooth restorations and disposing of mercury waste. This results in a significant increase in occupational exposure and risk of mercury intoxication. METHODS: To evaluate the occupational exposure of dental workers to amalgam in four dental clinics in Baghdad city, the concentrations of mercury vapor were measured seasonally from February to November 2016...
October 18, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29042442/1%C3%AE-25-dihydroxyvitamin-d3-promotes-bone-formation-by-promoting-nuclear-exclusion-of-the-foxo1-transcription-factor-in-diabetic-mice
#4
Yi Xiong, Yixin Zhang, Na Xin, Ying Yuan, Qin Zhang, Ping Gong, Yingying Wu
1α,25-Dihydroxyvitamin D3 (1,25(OH)2D3) is the active form of vitamin D, which is responsible for reducing the risk for diabetes mellitus (DM), decreasing insulin resistance, and improving insulin secretion. Previous studies have shown that 1,25(OH)2D3 inhibited the activity of FoxO1, which has been implicated in the regulation of glucose metabolism. However, its function and mechanism of action in DM-induced energy disorders and also in bone development remains unclear. Here, using in vitro and in vivo approaches including osteoblast-specific, conditional FoxO1-knockout mice, we demonstrate that 1,25(OH)2D3 ameliorates abnormal osteoblast proliferation in DM-induced oxidative stress conditions, and rescues the impaired glucose and bone metabolism through FoxO1 nuclear exclusion resulted from the activation of PI3K/Akt signaling...
October 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29039873/tillf%C3%A3-rlitliga-referensintervall-kr%C3%A3-vs-f%C3%A3-r-v%C3%A3-rdering-av-p-alp-nya-pediatriska-referensintervall-f%C3%A3-r-alkaliskt-fosfatas-har-klinisk-betydelse-f%C3%A3-r-att-hitta-r%C3%A3-tt-till-diagnosen
#5
Per Magnusson
Age- and gender-specific reference intervals are pivotal to ensure appropriate interpretation of plasma alkaline phosphatase activities in the lower range Hypophosphatasia (HPP) is an inborn error of metabolism caused by loss-of-function mutations of the ALPL gene that mainly express alkaline phosphatase (ALP) in bone and liver. The clinical expression of HPP is highly variable and is classified into six different forms mainly affecting bone and tooth mineralization. The prognosis for each of these HPP forms depends upon the severity of the skeletal disease which reflects the age at presentation...
October 16, 2017: Läkartidningen
https://www.readbyqxmd.com/read/29039747/development-of-useful-biomaterial-for-bone-tissue-engineering-by-incorporating-nano-copper-zinc-alloy-ncuzn-in-chitosan-gelatin-nano-hydroxyapatite-ch-g-nhap-scaffold
#6
Juan Carlos Forero, Eduardo Roa, Juan G Reyes, Cristian Acevedo, Nelson Osses
Ceramic and metallic nanoparticles can improve the mechanical and biological properties of polymeric scaffolds for bone tissue engineering (BTE). In this work, nanohydroxyapatite (nHAp) and nano-copper-zinc alloy (nCuZn) were added to a chitosan/gelatin (Ch/G) scaffold in order to investigate the effects on morphological, physical, and biocompatibility properties. Scaffolds were fabricated by a freeze-drying technique using different pre-freezing temperatures. Microstructure and morphology were studied by scanning electron microscopy (SEM), glass transition (Tg) was studied using differential scanning calorimetry (DSC), cell growth was estimated by MTT assay, and biocompatibility was examined in vitro and in vivo by histochemistry analyses...
October 17, 2017: Materials
https://www.readbyqxmd.com/read/29039519/runx3-plays-an-important-role-in-mediating-the-bmp9-induced-osteogenic-differentiation-of-mesenchymal-stem-cells
#7
Yufeng Wang, Qiaoling Feng, Caixia Ji, Xiaohua Liu, Li Li, Jinyong Luo
Although bone morphogenetic protein 9 (BMP9) is highly capable of promoting the osteogenic differentiation of mesenchymal stem cells (MSCs) both in vitro and in vivo, the molecular mechanisms involved remain to be fully elucidated. Runt-related transcription factor (RUNX)3 is an essential regulator of osteoblast/chondrocyte maturation. However, the exact role of RUNX3 in BMP9 osteoinductive activity is unknown. In this study, we sought to investigate the functional role of RUNX3 in the BMP9-induced osteogenic differentiation of MSCs...
September 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29038525/elevated-serum-alkaline-phosphatase-and-cardiovascular-or-all-cause-mortality-risk-in-dialysis-patients-a-meta-analysis
#8
Yu Fan, Xin Jin, Menglin Jiang, Na Fang
Studies on serum alkaline phosphatase (ALP) and mortality risk in patients with end-stage renal disease (ESRD) undergoing dialysis have yielded conflicting results. This meta-analysis was designed to assess the association of serum ALP levels with cardiovascular or all-cause mortality risk among patients on dialysis. PubMed and Embase databases were searched until March 2017 for studies evaluating the association of serum ALP levels and cardiovascular or all-cause mortality risk in adult patients with ESRD undergoing maintenance hemodialysis or chronic peritoneal dialysis...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037671/blue-mussel-mytilus-edulis-protein-hydrolysate-promotes-mouse-mesenchymal-stem-cell-differentiation-into-osteoblasts-through-up-regulation-of-bone-morphogenetic-protein
#9
Jun-Ho Hyung, Chang-Bum Ahn, Jae-Young Je
Seafood provides a range of health benefits due to its high-protein level. In this study, the osteogenic effect of blue mussel (Mytilus edulis) protein hydrolysates (BMPH) on osteoblast differentiation were examined using mouse mesenchymal stem cells (MSCs). A preparation we called BMPH<1kDa which showed the highest osteogenic effect in MSCs, was prepared by peptic hydrolysis. BMPH<1kDa treatment stimulated osteoblast differentiation with alkaline phosphatase (ALP) induction, osteocalcin and type I collagen activity as well as calcium deposition...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29036887/reference-intervals-for-non-fasting-cvd-lipids-and-inflammation-markers-in-pregnant-indigenous-australian-women
#10
Tracy L Schumacher, Christopher Oldmeadow, Don Clausen, Loretta Weatherall, Lyniece Keogh, Kirsty G Pringle, Kym M Rae
Indigenous Australians experience high rates of cardiovascular disease (CVD). The origins of CVD may commence during pregnancy, yet few serum reference values for CVD biomarkers exist specific to the pregnancy period. The Gomeroi gaaynggal research project is a program that undertakes research and provides some health services to pregnant Indigenous women. Three hundred and ninety-nine non-fasting samples provided by the study participants (206 pregnancies and 175 women) have been used to construct reference intervals for CVD biomarkers during this critical time...
October 14, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29033779/a-patient-with-nafcillin-associated-drug-induced-liver-failure
#11
Qin Rao, Isaiah Schuster, Talal Seoud, Kevin Zarrabi, Nirvani Goolsarran
Nafcillin-induced acute liver injury is a rare and potentially fatal complication that has been known since the 1960s but inadequately studied. At this time, the only proven treatment is early discontinuation of the drug. Because of the high prevalence of nafcillin class antibiotic use in the United States, it is important for clinicians to have a high clinical suspicion for this diagnosis. We present a case of liver failure attributable to nafcillin use in a 68-year-old male with a history methicillin-sensitive Staphylococcus and L3/L4 osteomyelitis...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29031226/ectopic-vascularized-bone-formation-by-human-mesenchymal-stem-cell-microtissues-in-a-biocomposite-scaffold
#12
Rajan Narayan, Tarun Agarwal, Debasish Mishra, Somnath Maji, Sujata Mohanty, Asok Mukhopadhyay, Tapas Kumar Maiti
Three-dimensional multicellular human bone marrow mesenchymal stem cells (hBM-MSCs) are showing a great promise in the repair of bone tissue due to its osteogenic differentiation potential, mimicking in vivo microenvironment and immunomodulatory property. In the present study, the potential of hBM-MSC microtissues (MTs) in combination with a biocomposite material to form vascularized bone-like tissue at an ectopic site in an immunocompromised mouse was evaluated. The scaffold was fabricated using gelatin, carboxymethyl cellulose, polyvinyl alcohol and nano-hydroxyapatite (GCnHP) by the freeze-drying method...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29027930/bioactive-coating-with-two-layer-hierarchy-of-relief-obtained-by-sol-gel-method-with-shock-drying-and-osteoblast-response-of-its-structure
#13
Elena G Zemtsova, Andrei Y Arbenin, Natalia M Yudintceva, Ruslan Z Valiev, Evgeniy V Orekhov, Vladimir M Smirnov
In this work, we analyze the efficiency of the modification of the implant surface. This modification was reached by the formation of a two-level relief hierarchy by means of a sol-gel approach that included dip coating with subsequent shock drying. Using this method, we fabricated a nanoporous layer with micron-sized defects on the nanotitanium surface. The present work continues an earlier study by our group, wherein the effect of osteoblast-like cell adhesion acceleration was found. In the present paper, we give the results of more detailed evaluation of coating efficiency...
October 13, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29021432/prediction-of-disseminated-intravascular-coagulation-by-liver-function-tests-in-patients-with-japanese-spotted-fever
#14
Yuichi Miyashima, Masaya Iwamuro, Michihiko Shibata, Yoshio Miyabe, Yoshinari Kawai, Masanobu Kaihara, Takehide Mitogawa, Masaru Harada
Objective Cases of Japanese spotted fever (JSF) are sometimes complicated by disseminated intravascular coagulation (DIC) with an abnormal liver function, resulting in unfavorable outcomes. The aim of the present study was to clarify the correlation between liver function test results and DIC scores. Methods Twenty patients diagnosed with JSF between April 2010 and April 2014 were enrolled. Age, gender, disturbance of consciousness, body temperature, pulse rate, presence of diffuse erythema, eschar and swelling of lymph nodes, laboratory test results at the time of initial presentation such as blood cell count, C-reactive protein, liver function, renal function and blood coagulation and fibrinolysis, maximum Japanese Association for Acute Medicine (JAAM) DIC score during the course of JSF, treatment and the prognosis were retrospectively reviewed...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29018990/safety-and-effectiveness-of-an-endoscopically-placed-duodenal-jejunal-bypass-device-endobarrier%C3%A2-outcomes-in-114-patients
#15
Patrice M Forner, Timothy Ramacciotti, John E Farey, Reginald V Lord
BACKGROUND: The duodenal-jejunal bypass liner (DJBL) is an endoscopically placed device designed to achieve weight loss and improve glycemic control in obese patients. Previous studies report promising results but typically included small patient numbers and short follow-up. This study aims to determine the safety and effectiveness of the device. METHODS: Study design: A series of all patients treated by the DJBL at our institutions. OUTCOME MEASUREMENTS: Weight loss, biochemical measures, complications...
October 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29017940/single-walled-carbon-nanotubes-as-delivery-vehicles-enhance-the-immunoprotective-effect-of-a-dna-vaccine-against-spring-viremia-of-carp-virus-in-common-carp
#16
Chen Zhang, Zhao Zhao, Ji-Wei Zha, Gao-Xue Wang, Bin Zhu
Spring viremia of carp virus (SVCV) is highly contagious and pathogenic to cyprinid fish, causing enormous economic losses in aquaculture. Efficient and economic prophylactic measure against is the most pressing desired for the common carp farming industry. In this research, single-walled carbon nanotubes (SWCNTs) as a candidate DNA vaccine carrier was administrated via bath (1, 5, 10, 20, 40 mg L(-1)) or injection (1, 4, 8, 12, 20 μg) in common carp juvenile, and the different immune treatments to induce immunoprotective effect was analyzed...
October 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29017699/urinary-calcium-excretion-and-bone-turnover-in-osteoporotic-patients%C3%A2
#17
Amr El-Husseini, Amit Chakraborty, Qingcong Yuan, Saqib Inayatullah, Heather Bush, B Peter Sawaya
INTRODUCTION: It is well documented that patients with osteoporosis (OP) have high incidence of hypercalciuria (HC). However, the mechanism of HC in patients with OP is not well established. It is thought to be the result of high bone turnover (HBT) with excessive bone resorption. OP also frequently presents with low bone turnover (LBT). At this time, it is not clear whether OP with LBT is also associated with hypercalciuria. PURPOSE: The purpose of this study is to evaluate urinary calcium excretion in osteoporotic patients with HBT and LBT...
October 11, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28992805/the-effects-of-liquid-crystal-based-composite-substrates-on-cell-functional-responses-of-human-umbilical-cord-derived-mesenchymal-stem-cells-by-mechano-regulatory-process
#18
Hao Wu, Yupan Shang, Jiaqing Zhang, Lek Hang Cheang, Xiaoli Zeng, Mei Tu
Physical properties of extracellular matrix, including elasticity and microstructure, have been considered as important factors inducing stem cell differentiation. This study developed a novel type of liquid crystal-based matrix by combining the elastic property of polyurethane with viscoelastic liquid crystal to generate a soft elastic response resembling physical microenvironment of stem cell niche, and explored the mechano-driving cell behaviors. Addition of varying liquid crystal concentration (10 wt%, 30 wt% and 50 wt%) had great effects on surface morphology and elastic modulus of liquid crystal/ polyurethane composite substrates...
October 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28992487/agnps-decorated-3d-printed-peek-implant-for-infection-control-and-bone-repair
#19
Lijun Deng, Yi Deng, Kenan Xie
Polyetheretherketone (PEEK) is an ideal substitute material for bone tissue engineering, which can avoid the stress shielding phenomenon due to its similar mechanical properties to natural human bone. Complex bone defect and postoperative infection are still two enormous challenges in orthopedic clinics. It's well-known that additive manufacturing possesses the merits of high-precision and rapid prototyping, thus it easily meets the needs of mold processing. In the present study, we developed a novel Ag-decorated 3D printed PEEK via catecholamine chemistry...
October 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28990619/exploring-the-tunable-excitation-of-qds-to-maximize-the-overlap-with-the-absorber-for-inner-filter-effect-based-phosphorescence-sensing-of-alkaline-phosphatase
#20
Jinyi Zhang, Xiaomei Lu, Yu Lei, Xiandeng Hou, Peng Wu
The inner filter effect (IFE) is an effective way for fluorescence modulation and thus has been extensively explored for the development of fluorescence assays. Theoretically, the key to maximize the sensitivity of IFE-based fluorescence assays is to enlarge the overlap between the absorption of the absorber and the excitation/emission of the fluorophore. Therefore, in this work, the tunable excitation of quantum dots (QDs) was explored for screening of the IFE pair having the best IFE-based assay sensitivity...
October 19, 2017: Nanoscale
keyword
keyword
47903
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"