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https://www.readbyqxmd.com/read/29678847/diagnostic-value-of-vitamin-d-status-and-bone-turnover-markers-in-rheumatoid-arthritis-complicated-by-osteoporosis
#1
Li-Ming Tan, Ting-Ting Long, Xiao-Lin Guan, Si-Fan Wu, Wei Zheng, Hui-Ying Fu, Qiao-Hua Wang, Yi-Mei Meng, Yang Wu, Ting-Ting Zeng, Yong-Jian Tian, Jian-Lin Yu, Juan-Juan Chen, Hua Li, Li-Ping Cao
OBJECTIVE: To research the diagnostic performance of clinical potential bone turnover indexes in rheumatoid arthritis (RA) complicated with osteoporosis (OP). METHODS: This study involved 87 RA patients, 48 with OP, and 39 without OP, and 204 non-RA control patients, including those with systemic lupus erythematosus, ankylosing spondylitis, primary Sjogren's syndrome, systemic sclerosis, and healthy patients. The levels of 25-hydroxyvitamin D [25(OH)D], β-crosslaps (β-CROSSL), parathyroid hormone (PTH) were measured by electrochemiluminescence (ECLIA), and the level of bone alkaline phosphatase (BALP) was measured by lectin affinity method...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29677587/effects-of-chronic-exposure-to-cadmium-and-temperature-alone-or-combined-on-the-threespine-stickleback-gasterosteus-aculeatus-interest-of-digestive-enzymes-as-biomarkers
#2
Younes Mohamed Ismail Hani, Cyril Turies, Olivier Palluel, Laurence Delahaut, Véronique Gaillet, Anne Bado-Nilles, Jean-Marc Porcher, Alain Geffard, Odile Dedourge-Geffard
The development of predictive, sensitive and reliable biomarkers is of crucial importance for aquatic biomonitoring to assess the effects of chemical substances on aquatic organisms, especially when it comes to combined effects with other stressors (e.g. temperature). The first purpose of the present study was to evaluate the single and combined effects of 90 days of exposure to an environmental cadmium concentration (0.5 μg L-1 ) and two water temperatures (16 and 21 °C) on different parameters. These parameters are involved in (i) the antioxidant system (superoxide dismutase activity -SOD- and total glutathione levels -GSH-), (ii) the energy metabolism, i...
April 12, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29676477/influence-of-estrogen-deficiency-on-guided-bone-augmentation-investigation-of-rat-calvarial-model-and-osteoblast-like-mc3t3-e1-cells
#3
Tatsuya Kubota, Akira Hasuike, Naoya Tsukune, Yasumasa Ozawa, Takanobu Yamamoto, Seiko Min, Masako Naito, Shuichi Sato
The effect of estrogen deficiency in bone augmentation, and the mechanisms by which estrogen deficiency impedes osteoblast differentiation and collagen matrix production, were examined. Twenty female Jcl:Wistar rats were divided into two groups: ovariectomized rats; and control rats. Guided bone augmentation was performed by positioning plastic caps in the calvarium of all animals at 8 wk after ovariectomy or sham surgery. Micro-computed tomography and histological sections were used to determine the amount of bone augmentation within the plastic caps...
April 20, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29675889/acute-liver-failure-caused-by-hepatitis-e-virus-genotype-3-and-4-a-systematic-review-and-pooled-analysis
#4
Samir Haffar, Shalimar, Ravinder Jeet Kaur, Zhen Wang, Larry Prokop, M Hassan Murad, Fateh Bazerbachi
BACKGROUND: Acute liver failure (ALF) caused by hepatitis E virus (HEV) genotype 3 and 4 has been rarely described. Due to the presence of a short golden therapeutic window in patients with viral ALF from other causes, it is possible that early recognition and treatment might reduce the morbidity and mortality. We performed a systematicac review and pooled analysis of ALF caused by HEV genotype 3 and 4. METHODS: Two reviewers appraised studies after searching multiple databases on June 12th , 2017...
April 19, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29674713/enzyme-catalyzed-ag-growth-on-au-nanoparticle-assembled-structure-for-highly-sensitive-colorimetric-immunoassay
#5
Xuan-Hung Pham, Eunil Hahm, Tae Han Kim, Hyung-Mo Kim, Sang Hun Lee, Yoon-Sik Lee, Dae Hong Jeong, Bong-Hyun Jun
We have developed a sensitive colorimetric immunoassay with broad dynamic range using enzyme-catalyzed Ag growth on gold nanoparticle (NP)-assembled silica (SiO2 @Au@Ag). To reduce Ag+ ion content and promote Ag growth on the assembled Au NPs, alkaline phosphatase (AP)-based enzymatic amplification was incorporated, which considerably increased the colorimetric read-out. As a model study, sandwich enzyme-linked immunosorbent assay (ELISA) was used to quantify target IgG. The immune complexes capture the Ab-IgG-AP-labeled detection Ab and trigger the enzyme-catalyzed reaction to convert 2-phospho-L-ascorbic acid to ascorbic acid in the presence of the target IgG...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674399/liver-chemistry-abnormalities-and-leg-oedema-in-rheumatoid-arthritis
#6
Eva Marianne van Soest, Anho Liem, Jende van Zeben
A 66-year-old man with seronegative, erosive rheumatoid arthritis for 12 years presented with malaise, elevated alkaline phosphatase and gamma-glutamyl transferase, and leg oedema. He subsequently developed ascites. No liver pathology was found, but cardiac analysis including right heart catheterisation revealed constrictive pericarditis. Rheumatoid constrictive pericarditis is a rare condition, but, despite current effective treatment for rheumatoid arthritis, still occurs. Diagnostic delay is frequent. Although mortality of the intervention is high, pericardiectomy is needed for most patients...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29671714/blood-chemistry-reference-values-for-free-ranging-asiatic-black-bears-ursus-thibetanus-by-season-age-and-sex
#7
Jeong-Jin Yang, Dong-Hyuk Jeong, Yoon-Kyu Lim
Physiological characteristics, such as blood chemistry values, are valuable for evaluating the health of the animals. To our knowledge, these values have never been reported for the free-ranging Asiatic black bear ( Ursus thibetanus; ABB). Thus, 28 blood chemistry values from 50 free-ranging ABBs captured in Jirisan National Park, Republic of Korea, from 2005 to 2016 were evaluated. The aim of this study was to establish blood chemistry reference values for the free-ranging ABBs during both the hibernating and nonhibernating seasons...
April 19, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29670890/correlations-between-microbial-communities-in-stool-and-clinical-indicators-in-patients-with-metabolic-syndrome
#8
Lang Lin, Zai-Bo Wen, Dong-Jiao Lin, Jiang-Ting Dong, Jie Jin, Fei Meng
AIM: To analyze the bacterial community structure and distribution of intestinal microflora in people with and without metabolic syndrome and combined these data with clinical indicators to determine relationships between selected bacteria and metabolic diseases. METHODS: Faecal samples were collected from 20 patients with metabolic syndrome and 16 controls at Cangnan People's Hospital, Zhejiang Province, China. DNA was extracted and the V3-V4 regions of the 16S rRNA genes were amplified for high throughput sequencing...
April 16, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29667554/establishment-of-novel-reporter-cells-stably-maintaining-transcription-factor-driven-human-secreted-alkaline-phosphatase-expression
#9
Riho Kurata, Asuka Kumagai, Xiaofeng Cui, Masamitsu Harada, Jun Nagai, Yasuhiro Yoshida, Kei-Ichi Ozaki, Yoshimasa Tanaka, Tomo Yonezawa
BACKGROUND: Transcriptional regulation is very important and pivotal function in myriad biological responses. Thus, methods to determine transcriptional activity are required in not only basic medical research but also drug discovery. We established novel reporter constructs using human secreted embryonic alkaline phosphatase (SEAP) and Epstein-Barr virus nuclear antigen (EBNA) 1, which can maintain constructs synchronized to host cell replication. METHODS: We established nuclear factor-kappa B (NFkB) or interferon regulatory factor (IRF) driven SEAP expression constructs and then, introduced them into culture cells...
April 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29666561/comparison-of-barricor%C3%A2-vs-lithium-heparin-tubes-for-selected-routine-biochemical-analytes-and-evaluation-of-post-centrifugation-stability
#10
Anne Marie Dupuy, Stéphanie Badiou, Delphine Daubin, Anne Sophie Bargnoux, Chloé Magnan, Kadda Klouche, Jean Paul Cristol
Introduction: Obtaining suitable results unaffected by pre- or postanalytical phases is pivotal for clinical chemistry service. We aimed comparison and stability of nine biochemical analytes after centrifugation using Barricor™ plasma tubes with mechanical separator vs standard Vacutainer® lithium heparin tubes. Materials and methods: We collected samples on six healthy volunteers and nine patients from intensive care units into 6 mL plastic Vacutainer® lithium heparin tubes and 5...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29664665/genetic-variation-in-nfkb1-gene-influences-liver-enzyme-levels-in-morbidly-obese-women
#11
Guven Yenmis, Tugba Soydas, Hulya Arkan, Ertugrul Tasan, Gonul Kanigur Sultuybek
BACKGROUND: Morbid obesity (MO), characterized by low-grade inflammation, is associated with increased C-reactive protein (CRP). NF-KB is a candidate factor for inflammatory responses in inflammatory diseases such as obesity. The objective of our study was to investigate the relationship between NFKB1 gene variations and the risk of MO in the context of the high/normal level of liver enzymes such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP)...
January 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29664498/-hypophosphatemia-in-preterm-infants-a-bimodal-disorder
#12
María Paz Cubillos Celis, Patricia Mena Nannig
New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29663832/therapeutic-role-of-calcium-and-vitamin-k3-in-chemically-induced-hepatocarcinogenesis-new-tools-for-cancer-treatment
#13
Firoz Anwar, Ruqaiyah Khan, Richa Sachan, Imran Kazmi, Alisha Rawat, Abdullah Sabih, Rajbala Singh, Muhammad Afzal, Aftab Ahmad, Abdulaziz S Al-Orab, F A Al-Abbasi, Prakash Chandra Bhatt, Vikas Kumar
HCC has been reported to be immensely occurring carcinoma worldwide. Recent days the mortality occurred due to liver cancer has also been found to be increased at an alarming speed affecting mostly the young patients. The aim of the current study was to decipher the role of calcium and vitamin K3 in the treatment of chemically induced hepatocarcinogenesis in the male Wistar rats. Liver cancer was induced via a subnecrogenic dose of 160 mg/kg body weight, diethylnitrosamine (DENA) when associated with fasting/refeeding in male Wistar rats...
April 17, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29663378/tyrosine-kinase-receptor-c-ros-oncogene-1-inhibition-alleviates-aberrant-bone-formation-of-twist-1-haploinsufficient-calvarial-cells-from-saethre-chotzen-syndrome-patients
#14
Esther Camp, Peter J Anderson, Andrew C W Zannettino, Carlotta A Glackin, Stan Gronthos
Saethre-Chotzen syndrome (SCS), associated with TWIST-1 mutations, is characterized by premature fusion of cranial sutures. TWIST-1 haploinsufficiency, leads to alterations in suture mesenchyme cellular gene expression patterns, resulting in aberrant osteogenesis and craniosynostosis. We analyzed the expression of the TWIST-1 target, Tyrosine kinase receptor c-ros-oncogene 1 (C-ROS-1) in TWIST-1 haploinsufficient calvarial cells derived from SCS patients and calvaria of Twist-1del/+ mutant mice and found it to be highly expressed when compared to TWIST-1 wild-type controls...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29659954/the-ossabaw-pig-is-a-suitable-translational-model-to-evaluate-dietary-patterns-and-coronary-artery-disease-risk
#15
Nirupa R Matthan, Gloria Solano-Aguilar, Huicui Meng, Stefania Lamon-Fava, Audrey Goldbaum, Maura E Walker, Saebyeol Jang, Sukla Lakshman, Aleksey Molokin, Yue Xie, Ethiopia Beshah, James Stanley, Joseph F Urban, Alice H Lichtenstein
Background: Animal models that mimic diet-induced human pathogenesis of chronic diseases are of increasing importance in preclinical studies. The Ossabaw pig is an established model for obesity-related metabolic disorders when fed extreme diets in caloric excess. Objective: To increase the translational nature of this model, we evaluated the effect of diets resembling 2 human dietary patterns, the Western diet (WD) and the Heart Healthy Diet (HHD), without or with atorvastatin (-S or +S) therapy, on cardiometabolic risk factors and atherosclerosis development...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29658921/site-directed-immobilization-of-bone-morphogenetic-protein-2-to-solid-surfaces-by-click-chemistry
#16
Claudia Siverino, Barbara Tabisz, Tessa Lühmann, Lorenz Meinel, Thomas Müller, Heike Walles, Joachim Nickel
Different therapeutic strategies for the treatment of non-healing long bone defects have been intensively investigated. Currently used treatments present several limitations that have led to the use of biomaterials in combination with osteogenic growth factors, such as bone morphogenetic proteins (BMPs). Commonly used absorption or encapsulation methods require supra-physiological amounts of BMP2, typically resulting in a so-called initial burst release effect that provokes several severe adverse side effects...
March 29, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29658832/the-associations-between-hypovitaminosis-d-higher-pth-levels-with-bone-mineral-densities-and-risk-of-the-10-year-probability-of-major-osteoporotic-fractures-in-chinese-patients-with-t2dm
#17
Xiao-Feng Wang, Jing-Jia Yu, Xiao-Jing Wang, Yi-Xuan Jing, Li-Hao Sun, Bei Tao, Wei-Qing Wang, Guang Ning, Jian-Min Liu, Hong-Yan Zhao
OBJECTIVE: In the current study, we investigated the vitamin D status, and its relationships with parathyroid hormone (PTH) levels, bone mineral density (BMD), and the 10-year probability of fractures in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This was a cross-sectional study of 785 patients. BMDs at the lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of 25-hydroxyvitamin D (25(OH)D) and intact PTH were also quantified...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29653303/effect-of-nanomaterials-on-arsenic-volatilization-and-extraction-from-flooded-soils
#18
Qing Huang, Shiwei Zhou, Lina Lin, Yongchun Huang, Fangjun Li, Zhengguo Song
Herein, we utilize sequential extraction and high-throughput sequencing to investigate the effects of nanomaterial additives on As volatilization from flooded soils. We reveal that maximum volatilization is achieved in the fourth week and is followed by stabilization. The extent of volatilization decreased in the order of control > nano-zerovalent iron >40-nm hydroxyapatite > nano-Fe3 O4  > 20-nm hydroxyapatite > multilayer graphene oxide > high-quality graphene oxide. The most abundant forms of As in soil corresponded to As-Fe and Al oxides...
April 10, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29651874/in-vitro-and-in-vivo-evaluation-of-osteoinductivity-and-bone-fusion-ability-of-an-activin-a-bmp2-chimera-ab204-a-comparison-study-between-ab204-and-rhbmp-2
#19
Guang Bin Zheng, Jae Hyup Lee, Yuan-Zhe Jin
This study compared osteoinductivity and osteogenic capacity between AB204 and rhBMP-2 using hMSCs in vitro and a beagle's posterolateral spinal fusion model. Cultured hMSCs were treated with AB204 or rhBMP-2 with low to high doses. Three male beagles were performed posterolateral spinal fusion with biphasic calcium phosphate (2 ml) + AB204 or rhBMP-2 (20, 50 or 200 µg). They were euthanized after 8 weeks. The fusion rate and bone formation of spine samples were examined. AB204 had higher alkaline phosphatase activity, mineralization and osteogenic-related gene expression than rhBMP-2...
April 13, 2018: Growth Factors
https://www.readbyqxmd.com/read/29649592/development-of-hybrid-scaffold-with-biomimetic-3d-architecture-for-bone-regeneration
#20
Priya Vashisth, Jayesh R Bellare
In the present study, a biomimetic three-dimensional hybrid scaffold has been designed considering the bone natural architecture with favorable interconnected porous structure, nano-microscale features and mechanical strength. The chief components of the hybrid scaffold are core-sheath nanofibers and hydrogel, suitably arranged to create a bone like microenvironment. Specifically, the core-sheath nanofibers were coiled tightly into a ring to mimic the osteon, and reinforced in a hydrogel matrix. Morphological analysis using SEM and 4D-X-ray microscopy revealed that the hybrid scaffold consists of coiled rings of nanofibers in highly porous hydrogel matrix showing structural similarity to osteons...
April 9, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
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