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Alkaline phosphatase high

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https://www.readbyqxmd.com/read/29449103/salmon-calcitonin-and-omega-3-fatty-acids-exhibit-antagonistic-and-non-additive-effects-in-experimental-diabetes
#1
Wale Johnson Adeyemi, Luqman Aribidesi Olayaki
Because optimising therapy for the management of diabetes mellitus remains challenging, the study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids (N-3 - eicosapentaenoic acid and docosahexaenoic acid-3:2), compared to metformin, on selected biochemical parameters in male Wistar rats, in an experimental model of diabetes. Forty rats were used for this study. They were divided into eight groups of five rats each, which included: Normal control; Diabetic (D) control; D + N-3; D + low dose Sct (Sct...
February 9, 2018: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29446693/hyperparathyroidism-mimicking-metastatic-bone-disease-a-case-report-and-review-of-literature
#2
Monica Gupta, Lalita Singhal, Akshay Kumar
Multiple osteolytic lesions are usually associated with metastatic involvement of the bone; however, metabolic bone diseases should also be included in the differential diagnosis. In this study, we describe a case of primary hyperparathyroidism (PHPT) with multiple osteolytic lesions that was diagnosed initially as having metastatic bone involvement. The laboratory results showed hypercalcemia and raised alkaline phosphatase along with fibrosis in the bone marrow biopsy with no increase in tumor markers and normal serum protein electrophoresis...
February 15, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29445277/effects-of-silica-gentamicin-nanohybrids-on-osteogenic-differentiation-of-human-osteoblast-like-saos-2-cells
#3
Wei He, Dina A Mosselhy, Yudong Zheng, Qingling Feng, Xiaoning Li, Xing Yang, Lina Yue, Simo-Pekka Hannula
Introduction: In recent years, there has been an increasing interest in silica (SiO 2 ) nanoparticles (NPs) as drug delivery systems. This interest is mainly attributed to the ease of their surface functionalization for drug loading. In orthopedic applications, gentamicin-loaded SiO 2 NPs (nanohybrids) are frequently utilized for their prolonged antibacterial effects. Therefore, the possible adverse effects of SiO 2 -gentamicin nanohybrids on osteogenesis of bone-related cells should be thoroughly investigated to ensure safe applications...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29444509/associations-between-intravenous-iron-inflammation-and-fgf23-in-non-dialysis-patients-with-chronic-kidney-disease-stages-3-5
#4
Katarzyna Muras-Szwedziak, Michal Nowicki
BACKGROUND/AIMS: Both iron deficiency and chronic inflammation are highly prevalent in patients with chronic kidney disease (CKD). The effect of intravenous iron infusion on mineral metabolism in CKD may be modified by inflammation. Intravenous iron theraphy may reduce peripheral degradation, secretion, clearence of iFGF23 and lead to hypophosphatemia. The aim of the study was to evaluate the effect of intravenous iron on mineral metabolism in CKD patients. METHODS: 35 non-dialysis patients with CKD stages 3-5...
February 8, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29438631/plasma-endocannabinoid-levels-in-lean-overweight-and-obese-humans-relationships-with-intestinal-permeability-markers-inflammation-and-incretin-secretion
#5
Tanya J Little, Nada Cvijanovic, Nicholas V DiPatrizio, Donovan A Argueta, Christopher K Rayner, Christine Feinle-Bisset, Richard L Young
INTRODUCTION/AIMS: Intestinal production of endocannabinoid and oleoylethanolamide (OEA) is impaired in high-fat diet/obese rodents, leading to reduced satiety. Such diets also alter the intestinal microbiome in association with enhanced intestinal permeability and inflammation, however little is known of these effects in humans. This study aimed to: (i) evaluate effects of lipid on plasma anandamide (AEA), 2-arachidonyl-sn-glycerol (2-AG) and OEA in humans, and (ii) examine relationships with intestinal permeability, inflammation markers and incretin hormone secretion...
February 13, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29434184/cyclosporin-a-aggravates-calcification-of-vascular-smooth-muscle-cells-under-high-glucose-conditions-with-a-calcifying-medium
#6
Dae Hee Kim, Keon Cheol Lee, Sang Youb Han
BACKGROUND Vascular calcification (VC) progresses substantially even after kidney transplantation, and is a predictor of morbidity and mortality. However, the effect of cyclosporin A (CsA) on VC has not been reported in diabetic kidney transplant patients. In this study, we evaluated the effect of CsA on the VC of mouse vascular smooth muscle cells (VSMCs) under high glucose (HG). MATERIAL AND METHODS To demonstrate the effect of CsA (1.0 µmol/L) and HG (30 mM) in the induction of the VC of the VSMCs, we determined alkaline phosphatase (ALP) activity, microscopic morphology of calcification, the expressions of the calcification and inflammation-related genes, and the intracellular calcium concentrations in VSMCs...
February 13, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29432984/high-strength-biodegradable-and-cytocompatible-alpha-tricalcium-phosphate-iron-composites-for-temporal-reduction-of-bone-fractures
#7
E B Montufar, M Casas-Luna, M Horynová, S Tkachenko, Z Fohlerová, S Diaz-de-la-Torre, K Dvorak, L Celko, J Kaiser
In this work alpha tricalcium phosphate (α-TCP)/ iron (Fe) composites were developed as a new family of biodegradable, load-bearing and cytocompatible materials. The composites with composition from pure ceramic to pure metallic samples were consolidated by pulsed electric current assisted sintering to minimise processing time and temperature while improving their mechanical performance. The mechanical strength of the composites was increased and controlled with the Fe content, passing from brittle to ductile failure...
February 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29432550/strategies-for-prediction-and-mitigation-of-radiation-induced-liver-toxicity
#8
Diego A S Toesca, Bulat Ibragimov, Amanda J Koong, Lei Xing, Albert C Koong, Daniel T Chang
Although well described in the 1960s, liver toxicity secondary to radiation therapy, commonly known as radiation-induced liver disease (RILD), remains a major challenge. RILD encompasses two distinct clinical entities, a 'classic' form, composed of anicteric hepatomegaly, ascites and elevated alkaline phosphatase; and a 'non-classic' form, with liver transaminases elevated to more than five times the reference value, or worsening of liver metabolic function represented as an increase of 2 or more points in the Child-Pugh score classification...
February 8, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29429227/-effect-of-nerve-growth-factor-on-osteogenic-potential-of-type-2-diabetic-mice-bone-marrow-stromal-cell-in-vitro
#9
G S Cui, J Y Zeng, J Zhang, R Lu
Objective: To study the effects of nerve growth factor (NGF) on the proliferation, osteogenic differentiation and mineralization of type 2 diabetic mice bone marrow stromal cell (BMSC), providing basis for clinical application of NGF. Methods: Three 8-week-old male db/db mice and two 8-week-old male C57BL/6J mice were used in the study. BMSC derived from femur were cultured though adherence method. BMSC of C57BL/6J mice and db/db mice was divided into normal group and diabetic group to conduct the osteogenic potential experiment, named experiment one...
February 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29428860/effects-of-long-term-fertilization-on-phod-harboring-bacterial-community-in-karst-soils
#10
Yajun Hu, Yinhang Xia, Qi Sun, Kunping Liu, Xiangbi Chen, Tida Ge, Baoli Zhu, Zhenke Zhu, Zhenhua Zhang, Yirong Su
Phosphorus (P) acquisition by plants from soil organic P mainly relies on microorganisms. Examining the community of functional microbes that encode phosphatases (e.g. PhoD) under different fertilization managements may provide valuable information for promoting soil organic P availability. Here, we investigated how the abundance and community diversity of phoD-harboring bacteria responded to long-term fertilization in Karst soils. Six fertilization treatments were designed as follows: non-fertilized control (CK), inorganic fertilization only (NPK), and inorganic fertilization combined with low- and high amounts of straw (LSNPK and HSNPK), or cattle manure (LMNPK and HMNPK)...
February 8, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29428859/decoupled-water-sediment-interactions-restrict-the-phosphorus-buffer-mechanism-in-agricultural-streams
#11
Gabriele Weigelhofer, José Pedro Ramião, Beate Pitzl, Elisabeth Bondar-Kunze, Joanna O'Keeffe
Our study aimed to explore the effects of agriculture on the phosphorus buffer capacity of 11 headwater streams in Austria. We used phosphorus adsorption curves and re-suspension experiments to determine both, the potential of the sediments to act as phosphorus source or sink and the actual phosphorus exchange between water and sediments. Additionally, we determined the alkaline phosphatase activity (APA) in epilithic and epipsammic biofilms as indicator for the phosphorus demand of the benthic and hyporheic community...
February 8, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29424259/increased-oxidative-damage-of-rna-in-liver-injury-caused-by%C3%A2-hepatitis-b-virus-hbv-infection
#12
Xin-Min Xu, Xiao-Yang Zhou, Xiang-Yu Li, Jie Guo, Hui-Zhu Wang, Yue Li, Cheng-Cheng Yang, Teng-Hui Liu, Jian-Ping Cai
To evaluate the urinary levels of 8-oxo-7,8-dihydro-2'deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) in liver injury patients with hepatitis B virus (HBV) infection and to explore the relationship between urinary 8-oxo-dGsn or 8-oxo-Gsn and degree of liver damage. We enrolled 138 liver injury patients with HBV infection and 169 age and sex matched healthy controls in this study. A sensitive and accurate isotope-diluted LC-MS/MS method was used to measure the urinary levels of 8-oxo-Gsn and 8-oxo-dGsn...
February 9, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29420074/extracellular-acidosis-suppresses-calcification-of-vascular-smooth-muscle-cells-by-inhibiting-calcium-influx-via-l-type-calcium-channels
#13
Shenglei Zhang, Jinsheng Xu, Yu Feng, Junxia Zhang, Liwen Cui, Huiran Zhang, Yaling Bai
Vascular calcification such as arteriosclerosis, which is characterized by a calcification of the tunica media, is a severe complication of chronic kidney disease (CKD), contributing to the high prevalence of cardiovascular morbidity and mortality in patients with CKD. An essential step during the development of arteriosclerosis is the transdifferentiation/calcification of vascular smooth muscle cells (VSMCs), resembling osteogenesis. Metabolic acidosis, a common clinical manifestation in CKD, is known to decrease vascular calcification...
February 8, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29415259/analysis-of-homologs-of-cry-toxin-receptor-related-proteins-in-the-midgut-of-a-non-bt-target-nilaparvata-lugens-st%C3%A3-l-hemiptera-delphacidae
#14
Ensi Shao, Li Lin, Sijun Liu, Jiao Zhang, Xuelin Chen, Li Sha, Zhipeng Huang, Biwang Huang, Xiong Guan
The brown planthopper (BPH) Nilaparvata lugens is one of the most destructive insect pests in the rice fields of Asia. Like other hemipteran insects, BPH is not susceptible to Cry toxins of Bacillus thuringiensis (Bt) or transgenic rice carrying Bt cry genes. Lack of Cry receptors in the midgut is one of the main reasons that BPH is not susceptible to the Cry toxins. The main Cry-binding proteins (CBPs) of the susceptible insects are cadherin, aminopeptidase N (APN), and alkaline phosphatase (ALP). In this study, we analyzed and validated de novo assembled transcripts from transcriptome sequencing data of BPH to identify and characterize homologs of cadherin, APN, and ALP...
February 5, 2018: Journal of Insect Science
https://www.readbyqxmd.com/read/29414645/activation-of-autophagy-is-required-for-oroxylin-a-to-alleviate-carbon-tetrachloride-induced-liver-fibrosis-and-hepatic-stellate-cell-activation
#15
Weiwei Chen, Zili Zhang, Zhen Yao, Ling Wang, Feng Zhang, Jiangjuan Shao, Anping Chen, Shizhong Zheng
Liver fibrosis is a reversible pathophysiological process correlated with intense repair and cicatrization mechanisms, and its end-stage cirrhosis is responsible for high morbidity and mortality worldwide. Interestingly, the use of natural products as a realistic option for the treatment of liver fibrosis has broadly been accepted. Oroxylin A, a safe and natural product, shows a wide range of pharmacological activities such as anti-inflammatory, anti-oxidant, and anti-tumor properties. However, the effects of Oroxylin A on liver fibrosis remain poorly understood...
January 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29412939/fast-and-sensitive-near-infrared-fluorescent-probes-for-alp-detection-and-3d-printed-calcium-phosphate-scaffold-imaging-in-vivo
#16
Chul Soon Park, Tai Hwan Ha, Moonil Kim, Naren Raja, Hui-Suk Yun, Mi Jeong Sung, Oh Seok Kwon, Hyeonseok Yoon, Chang-Soo Lee
Alkaline phosphatase (ALP) is a critical biological marker for osteoblast activity during early osteoblast differentiation, but few biologically compatible methods are available for its detection. Here, we describe the discovery of highly sensitive and rapidly responsive novel near-infrared (NIR) fluorescent probes (NIR-Phos-1, NIR-Phos-2) for the fluorescent detection of ALP. ALP cleaves the phosphate group from the NIR skeleton and substantially alters its photophysical properties, therefore generating a large "turn-on" fluorescent signal resulted from the catalytic hydrolysis on fluorogenic moiety...
May 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29409850/efficacy-and-safety-of-pueraria-candollei-var-mirifica-airy-shaw-suvat-niyomdham-for-menopausal-women-a-systematic-review-of-clinical-trials-and-the-way-forward
#17
Chuenjid Kongkaew, Norman C Scholfield, Teerapon Dhippayom, Piyameth Dilokthornsakul, Surasak Saokaew, Nathorn Chaiyakunapruk
ETHNOPHARMACOLOGICAL RELEVANCE: Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham (commonly termed P. mirifica, PM) growing in upland Thailand has a long history as a postmenopausal rejuvenant therapy for indigenants. Its amelioration of menopause symptoms in clinical trials was assessed. MATERIALS AND METHODS: International and Thai databases were searched from inception to February 2017. Clinical trials investigating effects of PM menopausal or postmenopausal women were included...
February 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29405933/laboratory-diagnosis-of-hypophosphatasia
#18
I Gennero, F Conte-Auriol, J-P Salles
The laboratory diagnosis of hypophosphatasia (HPP) is primarily based on the precise analysis of circulating serum alkaline phosphatase (ALP) activity, determined by biochemical assays. This analysis requires specific conditions of implementation and interpretation and should always be viewed in the light of the clinical and radiological data. Concerns regarding the normal ranges of ALP with respect to age, regarding ALP values that may overlap those of normal subjects in HPP patients, regarding apparently normal ALP values in cases of proven HPP, regarding differential diagnoses that may be responsible for low ALP values outside of HPP will be discussed...
May 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29404036/hepatoprotective-activity-of-macrothelypteris-torresiana-gaudich-aerial-parts-against-ccl4-induced-hepatotoxicity-in-rodents-and-analysis-of-polyphenolic-compounds-by-hptlc
#19
Sumanta Mondal, Debjit Ghosh, Seru Ganapaty, Surya Vamsi Gokul Chekuboyina, Manisha Samal
Macrothelypteris torresiana is a fern species belonging to family Thelypteridaceae. The present study was conducted to evaluate hepatoprotective potential of ethanol extract from M. torresiana aerial parts (EEMTAP) and detect the polyphenolic compounds present in the extract using high performance thin layer chromatography (HPTLC). Hepatoprotective potential of EEMTAP were tested at doses of 300 and 600 mg/kg, per os (p.o.), on Wistar albino rats. The extract and silymarin treated animal groups showed significant decrease in activities of different biochemical parameters like serum glutamic oxaloacetic transaminase (SGOT), serum glutamate-pyruvate transaminase (SGPT), alkaline phosphatase (ALP), which were elevated by carbon tetrachloride (CCl4) intoxication...
June 2017: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29404027/anti-atherosclerotic-activity-of-root-bark-of-premna-integrifolia-linn-in-high-fat-diet-induced-atherosclerosis-model-rats
#20
Chitra Subramani, Arivukkodi Rajakkannu, Arunadevi Rathinam, Sudesh Gaidhani, Ilavarasan Raju, Dhiman Vaidya Kartar Singh
Premna integrifolia Linn. is a medicinal plant used in "Dhasamula" drug preparation of Ayurvedic systems of medicine in the treatment of various ailments like bronchitis, dyspepsia, liver disorders, piles, constipation, hyperlipidemia and fever. The anti-atherosclerotic activity of hydroalcoholic extract (HAE) of root bark of P. integrifolia was evaluated in high fat diet induced atherosclerosis rats. Sixty Wistar rats were divided into six groups: the first group served as control, the second group was fed with high fat diet and the other three groups were fed with high fat diet along with various concentrations of HAE and the last group was treated with atorvastatin for 30 days...
April 2017: Journal of Pharmaceutical Analysis
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