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lipocalin 2

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https://www.readbyqxmd.com/read/29154418/measuring-non-polyaminated-lipocalin-2-for-cardiometabolic-risk-assessment
#1
Kangmin Yang, Han-Bing Deng, Andy W C Man, Erfei Song, Jialiang Zhang, Cuiting Luo, Bernard M Y Cheung, Kwok-Yung Yuen, Pia Søndergaard Jensen, Akhmadjon Irmukhamedov, Atlanta G I M Elie, Paul M Vanhoutte, Aimin Xu, Jo G R De Mey, Yu Wang
AIMS: Lipocalin-2 is a pro-inflammatory molecule characterized by a highly diversified pattern of expression and structure-functional relationships. In vivo, this molecule exists as multiple variants due to post-translational modifications and/or protein-protein interactions. Lipocalin-2 is modified by polyamination, which enhances the clearance of this protein from the circulation and prevents its excessive accumulation in tissues. On the other hand, animal studies suggest that non-polyaminated lipocalin-2 (npLcn2) plays a causal role in the pathogenesis of obesity-associated medical complications...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29149959/urinary-tissue-inhibitor-of-metalloproteinase-and-insulin-like-growth-factor-7-as-early-biomarkers-of-delayed-graft-function-after-kidney-transplantation
#2
J Yang, S Y Lim, M-G Kim, C-W Jung, W-Y Cho, S-K Jo
BACKGROUND: Recently, urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-7 (IGFBP-7), markers for G1 cell cycle arrest, have been identified and validated in predicting the development of acute kidney injury in critically ill patients. It is unknown, however, whether these two biomarkers could predict the development of delayed graft function (DGF) after kidney transplantation (KT). METHODS: This is a single-center, prospective, observational study...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29142952/serum-ngal-and-cystatin-c-comparison-with-urinary-albumin-to-creatinine-ratio-and-inflammatory-biomarkers-as-early-predictors-of-renal-dysfunction-in-patients-with-type-2-diabetes
#3
Marcelo R Bacci, Ethel Z Chehter, Ligia A Azzalis, Beatriz Costa de Aguiar Alves, Fernando L A Fonseca
Introduction: Diabetic nephropathy is associated with specific histological changes. Early detection of poor glomerular and tubular function can be achieved with biomarkers of diabetes. The aim of this study was to evaluate the accuracy of kidney dysfunction biomarkers in type 2 diabetes (T2D). Methods: Patients with T2D were grouped according to their glycated hemoglobin level. Patients' urine and blood samples were taken to measure cystatin C (CysC), neutrophil gelatinase-associated lipocalin, beta-trace protein levels, and the first morning void albumin-to-creatinine ratio...
March 2017: KI Reports
https://www.readbyqxmd.com/read/29141361/-effect-of-probucol-on-preventing-contrast-induced-nephropathy-in-patients-undergoing-percutaneous-coronary-intervention
#4
X Q Suo, S C Yang, Z H Ma, T T Sun, W Y Zhang, H L Cong, W H Lin, C Z Lu, F S Tian, N K Fu
Objective: To investigate the preventive effect, possible mechanism and safety of probucol on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods: A total of 641 patients with coronary heart disease were consecutively enrolled from Department of Cardiology, in Tianjin Chest Hospital, Tianjin TEDA International Cardiovascular Hospital, Tianjin First Central Hospital, Tianjin Fourth Central Hospital. They were randomly divided into probucol group (n=321) and control group (n=320)...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29138470/obesity-promoting-and-anti-thermogenic-effects-of-neutrophil-gelatinase-associated-lipocalin-in-mice
#5
Akira Ishii, Goro Katsuura, Hirotaka Imamaki, Hiroyuki Kimura, Keita P Mori, Takashige Kuwabara, Masato Kasahara, Hideki Yokoi, Kousaku Ohinata, Tomoko Kawanishi, Junichi Tsuchida, Yuji Nakamoto, Kazuwa Nakao, Motoko Yanagita, Masashi Mukoyama, Kiyoshi Mori
Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive. To study physiological role of LCN2 in energy homeostasis, we challenged female Lcn2 knockout (KO) and wild-type (WT) mice with high fat diet (HFD) or cold exposure. Under normal diet, physical constitutions of Lcn2 KO and WT mice were indistinguishable. During HFD treatment, Lcn2 KO mice exhibited larger brown adipose tissues (BAT), consumed more oxygen, ate more food and gained less body weights as compared to WT mice...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29135147/-biomarkers-of-renal-injury-in-contact-ureteral-lithotripsy
#6
A I Tarasenko, A M Pushkarev, I G Rakipov, A V Alekseev, Ya V Kondratenko, V N Pavlov
AIM: To optimize the transurethral endoscopic management of patients with ureterolithiasis by measuring biomarkers of renal parenchymal damage. MATERIALS AND METHODS: One hundred fifty-one patients with solitary ureteral stones were tested for levels of cystatin C, neutrophil gelatinase-associated lipocalin, 2-microglobulin and interleukin 18. RESULTS: An increase in the levels of markers of renal injury was observed both in the preoperative period and after CULT...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29131707/plasma-neutrophil-gelatinase-associated-lipocalin-measured-immediately-after-restoration-of-spontaneous-circulation-predicts-acute-kidney-injury-in-cardiac-arrest-survivors-who-underwent-therapeutic-hypothermia
#7
Dong Hun Lee, Byung Kook Lee, Yong Soo Cho, Yong Hun Jung, Sung Min Lee, Jung Soo Park, Kyung Woon Jeung
Early diagnosis of acute kidney injury (AKI) after cardiac arrest (CA) is challenging. We aimed to identify the diagnostic and prognostic performance of neutrophil gelatinase-associated lipocalin (NGAL) for AKI and its clinical outcomes. A retrospective observational study, involving adult comatose CA survivors treated with therapeutic hypothermia between May 2013 and December 2016, was conducted. AKI was classified according to the guidelines of Kidney Disease Improving Global Outcomes. NGAL levels were measured after return of spontaneous circulation (ROSC)...
November 13, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29123535/trait-and-marker-associations-in-oryza-nivara-and-o-rufipogon-derived-rice-lines-under-two-different-heat-stress-conditions
#8
V Vishnu Prasanth, M Suchandranath Babu, Ramana K Basava, V G N Tripura Venkata, Satendra K Mangrauthia, S R Voleti, Sarla Neelamraju
Wild species and derived introgression lines (ILs) are a good source of genes for improving complex traits such as heat tolerance. The effect of heat stress on 18 yield traits was studied in four treatments in two seasons, under field conditions by subjecting 37 ILs and recurrent parents Swarna and KMR3, N22 mutants, and wild type and 2 improved rice cultivars to heat stress using polycover house method in wet season and late sowing method in dry season. Normal grown unstressed plants were controls. Both correlation and path coefficient analysis showed that the major contributing traits for high yield per plant (YPP) under heat stress conditions were tiller number, secondary branches in panicle, filled grain number, and percent spikelet fertility...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29122892/subclinical-first-trimester-renal-abnormalities-are-associated-with-preeclampsia-in-normoalbuminuric-women-with-type-1-diabetes
#9
Clare B Kelly, Michelle B Hookham, Jeremy Y Yu, Alicia J Jenkins, Alison J Nankervis, Kristian F Hanssen, Satish K Garg, James A Scardo, Samar M Hammad, M Kathryn Menard, Christopher E Aston, Timothy J Lyons
OBJECTIVE: This study was conducted to determine the utility of tubular (urinary/plasma neutrophil gelatinase-associated lipocalin [NGAL] and urinary kidney injury molecule 1 [KIM-1]) and glomerular (estimated glomerular filtration rate [eGFR]) biomarkers in predicting preeclampsia (PE) in pregnant women with type 1 diabetes mellitus (T1DM) who were free of microalbuminuria and hypertension at the first trimester. RESEARCH DESIGN AND METHODS: This was a prospective study of T1DM pregnancy...
November 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29122651/downregulation-of-lipocalin-2-and-bim-expression-after-remote-limb-preconditioning-in-the-ischemic-rat-brain
#10
Mingli Liu, Jing Chen, Shufan Zhang, Chuancheng Ren
Although it has been proved that remote limb preconditioning (RPC) can exert neurological protection effects after ischemic cerebral stroke (ICS), the underlying mechanisms of RPC still need to be elucidated for its better transformation to clinical application. Lipocalin-2 (LCN2) was upregulated after cerebral ischemia and mediated reperfusion injury in the models of ischemic stroke. So here, we investigated that whether RPC could downregulate the levels of LCN2 protein and its receptor resulting from cerebral ischemia reperfusion (I/R) injury...
November 6, 2017: Brain Research
https://www.readbyqxmd.com/read/29120575/neutrophil-cd11b-cd64-and-lipocalin-2-early-diagnostic-markers-of-neonatal-sepsis
#11
Abeer Sheneef, Tamer Mohamed, Naglaa F Boraey, Mostafa A Mohammed
Neonatal sepsis remains a global health problem particularly in the developing countries. Its diagnosis remains one of the most difficult issues in clinical medicine. Many immunologic markers including neutrophils CD11b and CD 64 and Lipocalin-2 have been tested as biomarkers of neonatal sepsis. The aim of the present study was to assess the value of these markers for early diagnosis of neonatal sepsis. The study included 60 neonates with suspected neonatal sepsis and 20 apparently healthy controls. Lipocalin-2 serum level was assessed by ELISA while neutrophils CD11b and CD64 expressions were evaluated by flow cytometry...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29115890/exploiting-bilosomes-for-delivering-bioactive-polysaccharide-isolated-from-enteromorpha-intestinalis-for-hacking-hepatocellular-carcinoma
#12
Azza Abdelmageed Matloub, Alaa Hamed Salama, Hadeer Ahmed Aglan, Mona Mahmoud AbouSamra, Sahar Salah Mohamed ElSouda, Hanaa Hamdy Ahmed
Bile salts containing vesicles (bilosomes) represent a portentous vesicular carrier that showed prosperous results in delivering active moieties in the gastrointestinal tract (GIT). In this study, bilosomes were exploited to deliver sulphated polysaccharide-protein complexes of Enteromorpha intestinalis (EHEM) and enhance its activity against hepatocellular carcinoma as well as resist harsh GIT conditions. Bilosomes were prepared using the sodium salt of three different bile acids (cholic, deoxycholic, taurodeoxycholic) and two different non-ionic surfactants (Span 40 and 65)...
November 8, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29098551/ascites-neutrophil-gelatinase-associated-lipocalin-identifies-spontaneous-bacterial-peritonitis-and-predicts-mortality-in-hospitalized-patients-with-cirrhosis
#13
Giuseppe Cullaro, Grace Kim, Marcus R Pereira, Robert S Brown, Elizabeth C Verna
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is a marker of both tissue injury and infection. Urine NGAL levels strongly predict acute kidney injury and mortality in patients with cirrhosis, but ascites NGAL is not well characterized. We hypothesized that ascites NGAL level is a marker of spontaneous bacterial peritonitis (SBP) and mortality risk in patients with cirrhosis. METHODS: Hospitalized patients with cirrhosis and ascites undergoing diagnostic paracentesis were prospectively enrolled and followed until death or discharge...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29089666/clinical-relevance-of-ngal-mmp-9-pathway-in-patients-with-endometrial-cancer
#14
Aneta Cymbaluk-Płoska, Anita Chudecka-Głaz, Ewa Pius-Sadowska, Agnieszka Sompolska-Rzechuła, Karolina Chudecka, Michał Bulsa, Bogusław Machaliński, Janusz Menkiszak
The objectives of the study were to assess the relationship between the serum levels of MMP-9 and NGAL and the clinical staging and histopathological grade of the tumor. Lipocalin-2/NGAL and MMP-9 concentrations were quantified in serum by multiplex fluorescent bead-based immunoassays (Luminex Corporation, Austin, TX, USA). The AUC values for NGAL and MMP-9 were 0.9 and 0.78, respectively. The diagnostic potential of NGAL and MMP-9 in differentiating high-stage (FIGO III and IV) and low-stage (FIGO I and II) cancer and predicting the cell differentiation grade (G1 versus G3) on the basis of the analyses of AUC values was determined to be 0...
2017: Disease Markers
https://www.readbyqxmd.com/read/29079859/evaluation-of-decellularized-porcine-jejunum-as-a-matrix-for-lacrimal-gland-reconstruction-in-vitro-for-treatment-of-dry-eye-syndrome
#15
Isobel Massie, Kristina Spaniol, Andreas Barbian, Gereon Poschmann, Kai Stühler, Gerd Geerling, Marco Metzger, Sonja Mertsch, Stefan Schrader
Purpose: Dry eye syndrome (DES) can cause blindness in severe cases, but mainly palliative treatments exist. A tissue-engineered lacrimal gland (LG) could provide a curative treatment. We aimed to evaluate decellularized porcine jejunum (SIS-Muc) as a scaffold for porcine LG epithelial cells. Methods: To evaluate SIS-Muc as a potential scaffold, basement membrane proteins in SIS-Muc and native LG were compared (immunohistochemistry [IHC]). Porcine LG epithelial cells cultured on plastic were characterized (immunocytochemistry), and their culture supernatant was compared with porcine tears (proteomics)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29078046/dendritic-polyglycerol-sulfates-in-the-prevention-of-synaptic-loss-and-mechanism-of-action-on-glia
#16
Dusica Maysinger, Jeff Ji, Alexandre Moquin, Shireen Hossain, Mark A Hancock, Issan Zhang, Philip K Y Chang, Matthew Rigby, Madeleine Anthonisen, Peter Grutter, John C S Breitner, R Anne McKinney, Sabine Reimann, Rainer Haag, Gerhard Multhaup
Dendritic polyglycerols (dPG), particularly dendritic polyglycerol sulfates (dPGS), have been intensively studied due to their intrinsic anti-inflammatory activity. As related to brain pathologies involving neuroinflammation, the current study examined if dPG and dPGS can (i) regulate neuroglial activation, and (ii) normalize the morphology and function of excitatory postsynaptic dendritic spines adversely affected by the neurotoxic 42 amino acid amyloid-β (Aβ42) peptide of Alzheimer disease (AD). The exact role of neuroglia, such as microglia and astrocytes, remains controversial especially their positive and negative impact on inflammatory processes in AD...
October 27, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29077618/urinary-oxygenation-as-a-surrogate-measure-of-medullary-oxygenation-during-angiotensin-ii-therapy-in-septic-acute-kidney-injury
#17
Yugeesh R Lankadeva, Junko Kosaka, Roger G Evans, Rinaldo Bellomo, Clive N May
OBJECTIVES: Angiotensin II is an emerging therapy for septic acute kidney injury, but it is unknown if its vasoconstrictor action induces renal hypoxia. We therefore examined the effects of angiotensin II on intrarenal PO2 in ovine sepsis. We also assessed the validity of urinary PO2 as a surrogate measure of medullary PO2. DESIGN: Interventional study. SETTING: Research Institute. SUBJECTS: Sixteen adult Merino ewes (n = 8/group)...
October 26, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29069419/prediction-of-contrast-induced-acute-kidney-injury-using-novel-biomarkers-following-contrast-coronary-angiography
#18
M Connolly, M Kinnin, D Mc Eneaney, I Menown, M J Kurth, J Lamont, N Morgan, M Harbinson
Background: Chronic Kidney Disease (CKD) is a risk factor for contrast induced acute kidney injury (CI-AKI). Contrast angiography in CKD patients is a common procedure. Creatinine is a delayed marker of CI-AKI and delays diagnosis which results in significant morbidity and mortality. Aim: Early diagnosis of CI-AKI requires validated novel biomarkers. Design: A prospective observation study of 301 consecutive CKD patients undergoing coronary angiography was performed...
October 23, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29061384/motoneuron-degeneration-in-the-trigeminal-motor-nucleus-innervating-the-masseter-muscle-in-dystonia-musculorum-mice
#19
M Ibrahim Hossain, Masao Horie, Nozomu Yoshioka, Masayuki Kurose, Kensuke Yamamura, Hirohide Takebayashi
Dystonia musculorum (dt) mice, which have a mutation in the Dystonin (Dst) gene, are used as animal models to investigate the human disease known as hereditary sensory and autonomic neuropathy type VI. Massive neuronal cell death is observed, mainly in the peripheral nervous system (PNS) of dt mice. We and others have recently reported a histopathological feature of these mice that neurofilament (NF) accumulates in various areas of the central nervous system (CNS), including motor pathways. Although dt mice show motor disorder and growth retardation, the causes for these are still unknown...
October 20, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29056829/low-circulating-trail-levels-are-associated-with-increase-of-resistin-and-lipocalin-2-ngal-adipokines-in-postmenopausal-women
#20
Veronica Tisato, Paola Secchiero, Gloria Bonaccorsi, Carlo Bergamini, Pantaleo Greco, Giorgio Zauli, Carlo Cervellati
OBJECTIVE: Tumor necrosis factor- (TNF-) related apoptosis-inducing ligand (TRAIL) is attracting attention for its role in the physiopathology of metabolic disease/diabetes. Evidence suggests that it might protect against metabolic abnormalities driven by obesity-induced dysregulated secretion of adipokines, but this role of TRAIL has not yet been fully established. On this basis, we aimed to investigate the potential association between TRAIL and adipokine levels in a cohort of subjects in which age/gender/hormonal interferences were excluded...
2017: Mediators of Inflammation
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