Nicholas W Bateman, Tamara Abulez, Anthony R Soltis, Andrew McPherson, Seongmin Choi, Dale W Garsed, Ahwan Pandey, Chunqiao Tian, Brian L Hood, Kelly A Conrads, Pang-Ning Teng, Julie Oliver, Glenn Gist, Dave Mitchell, Tracy J Litzi, Christopher M Tarney, Barbara A Crothers, Paulette Mhawech-Fauceglia, Clifton L Dalgard, Matthew D Wilkerson, Mariaelena Pierobon, Emanuel F Petricoin, Chunhua Yan, Daoud Meerzaman, Clara Bodelon, Nicolas Wentzensen, Jerry S H Lee, David G Huntsman, Sohrab Shah, Craig D Shriver, Neil T Phippen, Kathleen M Darcy, David D L Bowtell, Thomas P Conrads, G Larry Maxwell
We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue specimens spanning a broad spectrum of purity. We identified patients with longer progression-free survival had increased immune-related signatures and validated proteins correlating with tumor-infiltrating lymphocytes in 65 tumors from an independent cohort of HGSOC patients, as well as with overall survival in an additional 126 HGSOC patient cohort...
March 13, 2024: NPJ Precision Oncology