keyword
https://read.qxmd.com/read/38483700/pyruvate-kinase-m2-nuclear-translocation-regulate-ferroptosis-associated-acute-lung-injury-in-cytokine-storm
#21
JOURNAL ARTICLE
Haiting Wang, Chenyu Fan, Xuelian Chen, Wei Zhou, Li Guo, Feng Zhao, Shuang Ye, Shuangjun He, Yi Chen
Cytokine storm (CS) is linked with macrophage dysfunction and acute lung injury (ALI), which can lead to patient mortality. Glycolysis is preferentially exploited by the pro-inflammatory macrophages, in which pyruvate kinase M2 (PKM2) is a critical enzyme. The mechanism underlying the link between CS and ALI involves cell death, with the recently discovered programmed cell death known as ferroptosis being involved. However, the relationship between the glycolysis and ferroptosis in the context of CS-related ALI remains unclear...
March 14, 2024: Inflammation
https://read.qxmd.com/read/38482922/neurotoxic-microglial-activation-via-ifn%C3%AE-induced-nrf2-reduction-exacerbating-alzheimer-s-disease
#22
JOURNAL ARTICLE
You Jung Kang, Seung Jae Hyeon, Amanda McQuade, Jiwoon Lim, Seung Hyun Baek, Yen N Diep, Khanh V Do, Yeji Jeon, Dong-Gyu Jo, C Justin Lee, Mathew Blurton-Jones, Hoon Ryu, Hansang Cho
Microglial neuroinflammation appears to be neuroprotective in the early pathological stage, yet neurotoxic, which often precedes neurodegeneration in Alzheimer's disease (AD). However, it remains unclear how the microglial activities transit to the neurotoxic state during AD progression, due to complex neuron-glia interactions. Here, the mechanism of detrimental microgliosis in AD by employing 3D human AD mini-brains, brain tissues of AD patients, and 5XFAD mice is explored. In the human and animal AD models, amyloid-beta (Aβ)-overexpressing neurons and reactive astrocytes produce interferon-gamma (IFNγ) and excessive oxidative stress...
March 14, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38482264/expanding-the-phenotypic-spectrum-chronic-kidney-disease-in-a-patient-with-combined-oxidative-phosphorylation-defect-21
#23
A Paripović, A Maver, N Stajić, J Putnik, S Ostojić, B Alimpić, N Ilić, A Sarajlija
INTRODUCTION: Pathogenic variants in TARS2 are associated with combined oxidative phosphorylation deficiency 21 (COXPD21), an autosomal recessive disorder usually presenting as mitochondrial encephalomyopathy. Kidney impairment has been documented in a minority of COXPD21 patients, mostly with distal renal tubular acidosis. CASE REPORT: We report on the first COXPD21 patient with generalized tubular dysfunction and early childhood progression to chronic kidney disease (CKD)...
December 2023: Balkan Journal of Medical Genetics: BJMG
https://read.qxmd.com/read/38481546/eriodictyol-attenuates-doxorubicin-induced-nephropathy-by-activating-the-ampk-nrf2-signalling-pathway
#24
JOURNAL ARTICLE
Rehab Mustafa Badi, Eman Farok Khaleel, Huda Hammed Satti, Rehan Monir
Doxorubicin (DOX), an anthracycline chemotherapy, plays a prominent role in the treatment of various cancers. Unfortunately, its nephrotoxic effects limit its dosing and expose cancer survivors to increased morbidity and mortality. This study examined the nephroprotective effects of eriodictyol, a natural polyphenolic flavanone, in DOX-treated rats and the molecular pathways involved. Forty adult rats were divided into five groups (8/group): Control; eriodictyol (20 mg/kg/day); DOX (2.5 mg/kg, twice/week); DOX + Eriodictyol; and DOX + Eriodictyol + Compound C (CC), an AMPK inhibitor (0...
March 2024: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/38481385/sirt5-mediated-lysine-desuccinylation-regulates-oxidative-stress-adaptation-in-magnaporthe-oryzae-during-host-intracellular-infection
#25
JOURNAL ARTICLE
Zhiyong Ren, Xiang Dong, Lun Guan, Lei Yang, Caiyun Liu, Xuan Cai, Hong Hu, Ziwei Lv, Hao Liu, Lu Zheng, Junbin Huang, Richard A Wilson, Xiao-Lin Chen
Plant pathogenic fungi elaborate numerous detoxification strategies to suppress host reactive oxygen species (ROS), but their coordination is not well-understood. Here, we show that Sirt5-mediated protein desuccinylation in Magnaporthe oryzae is central to host ROS detoxification. SIRT5 encodes a desuccinylase important for virulence via adaptation to host oxidative stress. Quantitative proteomics analysis identified a large number of succinylated proteins targeted by Sirt5, most of which were mitochondrial proteins involved in oxidative phosphorylation, TCA cycle, and fatty acid oxidation...
March 14, 2024: New Phytologist
https://read.qxmd.com/read/38480868/proteogenomic-analysis-of-enriched-hgsoc-tumor-epithelium-identifies-prognostic-signatures-and-therapeutic-vulnerabilities
#26
JOURNAL ARTICLE
Nicholas W Bateman, Tamara Abulez, Anthony R Soltis, Andrew McPherson, Seongmin Choi, Dale W Garsed, Ahwan Pandey, Chunqiao Tian, Brian L Hood, Kelly A Conrads, Pang-Ning Teng, Julie Oliver, Glenn Gist, Dave Mitchell, Tracy J Litzi, Christopher M Tarney, Barbara A Crothers, Paulette Mhawech-Fauceglia, Clifton L Dalgard, Matthew D Wilkerson, Mariaelena Pierobon, Emanuel F Petricoin, Chunhua Yan, Daoud Meerzaman, Clara Bodelon, Nicolas Wentzensen, Jerry S H Lee, David G Huntsman, Sohrab Shah, Craig D Shriver, Neil T Phippen, Kathleen M Darcy, David D L Bowtell, Thomas P Conrads, G Larry Maxwell
We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue specimens spanning a broad spectrum of purity. We identified patients with longer progression-free survival had increased immune-related signatures and validated proteins correlating with tumor-infiltrating lymphocytes in 65 tumors from an independent cohort of HGSOC patients, as well as with overall survival in an additional 126 HGSOC patient cohort...
March 13, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38480845/prodh-safeguards-human-naive-pluripotency-by-limiting-mitochondrial-oxidative-phosphorylation-and-reactive-oxygen-species-production
#27
JOURNAL ARTICLE
Cheng Chen, Qianyu Liu, Wenjie Chen, Zhiyuan Gong, Bo Kang, Meihua Sui, Liming Huang, Ying-Jie Wang
Naive human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-localized proline metabolism enzyme, is dramatically upregulated in naive hESCs compared to their primed counterparts. The upregulation of PRODH is induced by a reduction in c-Myc expression that is dependent on PD0325901, a MEK inhibitor routinely present in naive hESC culture media...
March 13, 2024: EMBO Reports
https://read.qxmd.com/read/38480001/phloroglucinol-enhances-anagen-signaling-and-alleviates-h-2-o-2-induced-oxidative-stress-in-human-dermal-papilla-cells
#28
JOURNAL ARTICLE
Seokmuk Park, Ye Jin Lim, Hee Su Kim, Hee-Jae Shin, Ji-Seon Kim, Jae Nam Lee, Jae Ho Lee, Seunghee Bae
Phloroglucinol (PG) is one of the abundant isomeric benzenetriols in brown algae. Due to its polyphenolic structure, PG exhibits various biological activities. However, the impact of PG on anagen signaling and oxidative stress in human dermal papilla cells (HDPCs) is unknown. In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling...
March 8, 2024: Journal of Microbiology and Biotechnology
https://read.qxmd.com/read/38479853/organocatalyzed-amine-free-o-phosphorylation-of-alcohols-with-4-methylpyridine-n-oxide
#29
JOURNAL ARTICLE
Keisuke Yoshida, Wataru Hirano, Ryuuki Ota, Shinji Kitagaki
Amine-free phosphorylation of various alcohols was developed with 4-methylpyridine N-oxide in the presence of 4 Å molecular sieves at room temperature. This mild method gave various phosphorylated products in high yield and could be applied to acid- or base-sensitive substrates. Furthermore, this method was also effective for the chemoselective phosphorylation of diols or polyols.
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38479439/the-immune-cell-transcriptome-is-modulated-by-vitamin-d-3-supplementation-in-people-with-a-first-demyelinating-event-participating-in-a-randomized-placebo-controlled-trial
#30
JOURNAL ARTICLE
Wei Zhen Yeh, Melissa Gresle, Rodney Lea, Bruce Taylor, Robyn M Lucas, Anne-Louise Ponsonby, Deborah Mason, Julie Andrew, Hamish Campbell, Julia Morahan, Sandeep Sampangi, Maria Pia Campagna, Jim Stankovich, Anneke Van der Walt, Vilija Jokubaitis, Helmut Butzkueven
Vitamin D deficiency is a risk factor for developing multiple sclerosis. The PrevANZ trial was conducted to determine if vitamin D3 supplementation can prevent recurrent disease activity in people with a first demyelinating event. As a sub-study of this trial, we investigated the effect of supplementation on peripheral immune cell gene expression. Participants were randomized to 1000, 5000 or 10,000 international units daily of vitamin D3 or placebo. Peripheral blood was collected at baseline and 12 weeks and sent for ribonucleic acid sequencing...
March 11, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38479314/polystyrene-microplastics-impair-the-functions-of-cultured-mouse-leydig-tm3-and-sertoli-tm4-cells-by-inducing-mitochondrial-endoplasmic-reticulum-damage
#31
JOURNAL ARTICLE
Giulia Grillo, Sara Falvo, Debora Latino, Gabriella Chieffi Baccari, Massimo Venditti, Maria Maddalena Di Fiore, Sergio Minucci, Alessandra Santillo
Many laboratory studies demonstrated that the exposure to microplastics causes testosterone deficiency and spermatogenic impairment in mammals; however, the mechanism underlying this process remains still unclear. In this study, we investigated the effects of polystyrene microplastics (PS-MP) on the proliferation and functionality of cultured Leydig (TM3) and Sertoli (TM4) cells, focusing on the mitochondrial compartment and its association with the endoplasmic reticulum (ER). The in vitro exposure to PS-MP caused a substantial reduction in cellular viability in TM3 and TM4 cells...
March 12, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38479243/nobiletin-enhances-mitochondrial-function-by-regulating-sirt1-pgc-1%C3%AE-signaling-in-porcine-oocytes-during-in-vitro-maturation
#32
JOURNAL ARTICLE
Song-Hee Lee, Xiao-Han Li, Qin-Yue Lu, Cheng-Lin Zhan, Ji-Dam Kim, Gyu-Hyun Lee, Jae-Min Sim, Xiang-Shun Cui
Nobiletin is a natural flavonoid found in citrus fruits with beneficial effects, including anti-inflammatory, anti-cancer and anti-oxidation effects. The aim of this study was to investigate whether nobiletin improves mitochondrial function in porcine oocytes and examine the underlying mechanism. Oocytes enclosed by cumulus cells were cultured in TCM-199 for 44 h with 0.1% dimethyl sulfoxide (control), or supplemented with 5, 10, 25, and 50 μM of nobiletin (Nob5, Nob10, Nob25, and Nob50, respectively)...
March 5, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38479223/inhibition-of-glycogen-synthase-kinase-3-enhances-nrf2-protein-stability-nuclear-localisation-and-target-gene-transcription-in-pancreatic-beta-cells
#33
JOURNAL ARTICLE
Chinmai Patibandla, Lidy van Aalten, Albena T Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D McNeilly, John D Hayes, James Cantley, Calum Sutherland
Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related factor-2) regulates the adaptation to oxidative stress, and its activity is negatively regulated by the redox-sensitive CUL3 (cullin-3) ubiquitin ligase substrate adaptor KEAP1 (Kelch-like ECH-associated protein-1). Additionally, NRF2 is repressed by the insulin-regulated Glycogen Synthase Kinase-3 (GSK3). We have demonstrated that phosphorylation of NRF2 by GSK3 enhances β-TrCP (beta-transducin repeat-containing protein) binding and ubiquitylation by CUL1 (cullin-1), resulting in increased proteasomal degradation of NRF2...
March 7, 2024: Redox Biology
https://read.qxmd.com/read/38478538/integrated-transcriptome-and-proteome-analysis-reveals-the-unique-molecular-features-and-nutritional-components-on-the-muscles-in-chinese-taihe-black-bone-silky-fowl-chicken
#34
JOURNAL ARTICLE
Guanghua Xiong, Wanqing Chen, Kai Jiang, Shuyuan Liu, Juan Li, Xinjun Liao
The Taihe Black-Bone silky fowl chicken (BB-sfc) is a renowned dietary and medicinal chicken globally recognized for its high nutritional and medicinal value. Compared to the local Black-Bone black-feathered chicken (BB-bfc), the Taihe silky fowl chicken has higher levels of amino acids, trace elements, and unsaturated fatty acids in their muscles, which offer anti-aging, anti-cancer, and immune enhancing benefits. Despite this, the unique nutritional components, genes, and proteins in Taihe silky fowl chicken muscles are largely unknown...
2024: PloS One
https://read.qxmd.com/read/38478467/immuno-metabolic-reprogramming-of-t-cell-a-new-frontier-for-pharmacotherapy-of-rheumatoid-arthritis
#35
REVIEW
Sourav Mondal, Sarthak Saha, Debjeet Sur
Rheumatoid arthritis (RA) is a persistent autoimmune condition characterized by ongoing inflammation primarily affecting the synovial joint. This inflammation typically arises from an increase in immune cells such as neutrophils, macrophages, and T cells (TC). TC is recognised as a major player in RA pathogenesis. The involvement of HLA-DRB1 and PTPN-2 among RA patients confirms the TC involvement in RA. Metabolism of TC is maintained by various other factors like cytokines, mitochondrial proteins & other metabolites...
March 13, 2024: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/38478245/monitoring-adsc-metabolism-using-the-seahorse-analyzer
#36
JOURNAL ARTICLE
Daniel Rittenhouse, Kevin J Zwezdaryk
Bioenergetic and biosynthetic processes are key indicators regulating adipose-derived stromal/stem cell (ADSC) function, health, and differentiation. A common method used to metabolically profile cells is the Seahorse XF Analyzer. This live-cell assay can be used to define key metabolic pathways, including glycolysis and oxidative phosphorylation. Here, we share optimized protocols to characterize metabolism of ADSCs under basal conditions and provide insight into further assays defining metabolic changes and/or dependency during ADSC differentiation...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38478170/fam83b-regulates-mitochondrial-metabolism-and-anti-apoptotic-activity-in-pulmonary-adenocarcinoma
#37
JOURNAL ARTICLE
Jiajia Wang, Panpan Li, Limin Sun, Jing Zhang, Ke Yue, Yan Wang, Xiaojuan Wu
Chemotherapy is an effective therapeutic modality; nevertheless, a significant proportion of patients diagnosed with lung adenocarcinoma (LUAD) demonstrate resistance to chemotherapy. Therefore, it is crucial to understand the potential regulatory mechanisms to develop novel treatment strategies. This study aims to understand how increased FAM83B expression impacts mitochondrial activity, cell apoptosis, and chemotherapy effectiveness in LUAD. Multiple assays, such as CCK8, wound healing, EdU, and transwell assays, were employed to confirm the augmented chemotherapy resistance, heightened cell proliferation, migration, and invasion caused by FAM83B overexpression in LUAD cells...
March 13, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38476973/sirt3-expression-predicts-overall-survival-and-neoadjuvant-chemosensitivity-in-triple-negative-breast-cancer
#38
JOURNAL ARTICLE
Lvwen Ning, Ni Xie
BACKGROUND: The Sirtuin (SIRT) family consists of seven evolutionary conserved NAD-dependent deacetylases that play important roles in various cancers, including breast cancer (BC). SIRTs expression has been reported to have prognostic value in BC, but these studies used limited sample size and yielded inconsistent conclusions. This study evaluated the association of SIRT3 and other SIRT family members with survival and neoadjuvant chemotherapy outcomes. METHODS: BC patients' data was obtained from the TCGA-BRCA, METABRIC and GEO databases, comprising 4336 samples...
2024: Cancer Management and Research
https://read.qxmd.com/read/38475850/mitochondrial-perturbation-in-immune-cells-enhances-cell-mediated-innate-immunity-in-drosophila
#39
JOURNAL ARTICLE
Laura Vesala, Yuliya Basikhina, Tea Tuomela, Anssi Nurminen, Emilia Siukola, Pedro F Vale, Tiina S Salminen
BACKGROUND: Mitochondria participate in various cellular processes including energy metabolism, apoptosis, autophagy, production of reactive oxygen species, stress responses, inflammation and immunity. However, the role of mitochondrial metabolism in immune cells and tissues shaping the innate immune responses are not yet fully understood. We investigated the effects of tissue-specific mitochondrial perturbation on the immune responses at the organismal level. Genes for oxidative phosphorylation (OXPHOS) complexes cI-cV were knocked down in the fruit fly Drosophila melanogaster, targeting the two main immune tissues, the fat body and the immune cells (hemocytes)...
March 13, 2024: BMC Biology
https://read.qxmd.com/read/38475733/the-micro-743a-3p-gstm1-pathway-is-an-endogenous-protective-mechanism-against-alcohol-related-liver-disease-in-mice
#40
JOURNAL ARTICLE
Tiantian Xu, Yan Pan, Qinchao Ding, Feiwei Cao, Kaixin Chang, Jiannan Qiu, Hui Zhuge, Liuyi Hao, Haibin Wei, Caijuan Si, Xiaobing Dou, Songtao Li
BACKGROUND AND AIMS: Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related liver disease (ALD). However, whether and how hepatic GSTM1 determines the development of ALD is largely unclear. This study was designed to elucidate the role and potential mechanism(s) of hepatic GSTM1 in the pathological process of ALD. METHODS: GSTM1 was detected in the liver of various ALD mice models and cultured hepatocytes...
March 12, 2024: Cellular & Molecular Biology Letters
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