Felipe Gouvea de Souza, Caio S Silva, Gilderlanio S de Araújo, Mayara N Santana-da-Silva, Angélica Rita Gobbo, Moisés Batista da Silva, Pablo Pinto, Patrícia Fagundes da Costa, Claudio Guedes Salgado, Ândrea Ribeiro-Dos-Santos, Giovanna C Cavalcante
Leprosy is a chronic bacterial infection mainly caused by Mycobacterium leprae that primarily affects skin and peripheral nerves. Due to its ability to absorb carbon from the host cell, the bacillus became dependent on energy production, mainly through oxidative phosphorylation. In fact, variations in genes of Complex I of oxidative phosphorylation encoded by mtDNA have been associated with several diseases in humans, including bacterial infections, which are possible influencers in the host response to leprosy...
March 16, 2024: Scientific Reports