keyword
https://read.qxmd.com/read/38493220/mitochondrial-variants-of-complex-i-genes-associated-with-leprosy-clinical-subtypes
#1
JOURNAL ARTICLE
Felipe Gouvea de Souza, Caio S Silva, Gilderlanio S de Araújo, Mayara N Santana-da-Silva, Angélica Rita Gobbo, Moisés Batista da Silva, Pablo Pinto, Patrícia Fagundes da Costa, Claudio Guedes Salgado, Ândrea Ribeiro-Dos-Santos, Giovanna C Cavalcante
Leprosy is a chronic bacterial infection mainly caused by Mycobacterium leprae that primarily affects skin and peripheral nerves. Due to its ability to absorb carbon from the host cell, the bacillus became dependent on energy production, mainly through oxidative phosphorylation. In fact, variations in genes of Complex I of oxidative phosphorylation encoded by mtDNA have been associated with several diseases in humans, including bacterial infections, which are possible influencers in the host response to leprosy...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38492879/skeletal-muscle-atrophy-after-sciatic-nerve-damage-mechanistic-insights
#2
REVIEW
Aarti Yadav, Rajesh Dabur
Sciatic nerve injury leads to molecular events that cause muscular dysfunction advancement in atrophic conditions. Nerve damage renders muscles permanently relaxed which elevates intracellular resting Ca2+ levels. Increased Ca2+ levels are associated with several cellular signaling pathways including AMPK, cGMP, PLC-β, CERB, and calcineurin. Also, multiple enzymes involved in the tricarboxylic acid cycle and oxidative phosphorylation are activated by Ca2+ influx into mitochondria during muscle contraction, to meet increased ATP demand...
March 14, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38492876/jak2-stat3-as-a-new-potential-target-to-manage-neurodegenerative-diseases-an-interactive-review
#3
REVIEW
Siva Prasad Panda, Adarsh Kesharwani, Samaresh Datta, D S N B K Prasanth, Sunil Kumar Panda, Ajay Guru
Neurodegenerative diseases (NDDs) are a collection of incapacitating disorders in which neuroinflammation and neuronal apoptosis are major pathological consequences due to oxidative stress. Neuroinflammation manifests in the impacted cerebral areas as a result of pro-inflammatory cytokines stimulating the Janus Kinase2 (JAK2)/Signal Transducers and Activators of Transcription3 (STAT3) pathway via neuronal cells. The pro-inflammatory cytokines bind to their respective receptor in the neuronal cells and allow activation of JAK2...
March 14, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38491972/platycodin-d-ameliorates-cognitive-impairment-in-type-2-diabetes-mellitus-mice-via-regulating-pi3k-akt-gsk3%C3%AE-signaling-pathway
#4
JOURNAL ARTICLE
Ya-Wei Lu, Li-Ya Xie, Meng-Han Qi, Shen Ren, Yue-Qi Wang, Jun-Nan Hu, Zi Wang, Shan Tang, Jing-Tian Zhang, Wei Li
Objectives: The aim of this study was to investigate the ameliorative effect of platycodin D (PD) on cognitive dysfunction in type 2 diabetes mellitus (T2DM) and its potential molecular mechanisms of action in vivo and in vitro. Materials and methods: An animal model of cognitive impairment in T2DM was established using a single intraperitoneal injection of streptozotocin (100 mg/kg) after 8 weeks of feeding a high-fat diet to C57BL/6 mice. In vitro, immunofluorescence staining and Western blot were employed to analyze the effects of PD on glucose-induced neurotoxicity in mouse hippocampal neuronal cells (HT22)...
March 16, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38491378/hypoxia-promotes-metastasis-by-relieving-mir-598-3p-restricted-glycolysis-in-gastric-cancer
#5
JOURNAL ARTICLE
Wei Zhou, Mengyuan Tang, Dan He, Yi Shen, Ziwei Huang, Wenxin Xia, Zhiyun Wu, Wenxiang Wei, Hui Zheng, Qi Wang, Weifeng Shi, Jingting Jiang
The activation of glycolysis, particularly in the context of reprogrammed energy metabolism, is increasingly recognized as a significant characteristic of cancer. However, the precise mechanisms by which glycolysis is promoted in metastatic gastric cancer cells under normal oxygen conditions remain poorly understood. MicroRNAs (miRNAs) play a crucial role in the development of malignant phenotypes in gastric cancer. Nevertheless, our understanding of the specific involvement of miRNAs in hypoxia-induced metabolic shifting and the subsequent metastatic processes is limited...
March 15, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38491252/a-self-amplifying-loop-of-tp53inp1-and-p53-drives-oxidative-stress-induced-apoptosis-of-bone-marrow-mesenchymal-stem-cells
#6
JOURNAL ARTICLE
Fanchao Li, Fei Zhang, Tao Wang, Zhihong Xie, Hong Luo, Wentao Dong, Jian Zhang, Chao Ren, Wuxun Peng
Bone marrow mesenchymal stem cell (BMSC) transplantation is a promising regenerative therapy; however, the survival rate of BMSCs after transplantation is low. Oxidative stress is one of the main reasons for the high apoptosis rate of BMSCs after transplantation, so there is an urgent need to explore the mechanism of oxidative stress-induced apoptosis of BMSCs. Our previous transcriptome sequencing results suggested that the expression of P53-induced nuclear protein 1 (TP53INP1) and the tumor suppressor P53 (P53) was significantly upregulated during the process of oxidative stress-induced apoptosis of BMSCs...
March 16, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38490352/transgenerational-toxicity-induced-by-maternal-afb-1-exposure-in-caenorhabditis-elegans-associated-with-underlying-epigenetic-regulations
#7
JOURNAL ARTICLE
Hongyuan Zhou, Sirui Ren, Yulian Yang, Yuxian Qin, Ting Guo, Ying Zhou, Yuhao Zhang, Liang Ma
Aflatoxin B1 (AFB1 ), usually seriously contaminates in grain and oil foods or feed, displayed significant acute and chronic toxic effects in human and animal populations. However, little is known about the transgenerational toxic effects induced by a maternal AFB1 intake at a lower dose on offspring. In our study, only parental wild-type Caenorhabditis elegans was exposed to AFB1 (0-8 μg/ml) and the following three filial generations were grown on AFB1 -free NGM. Results showed that the toxic effects of AFB1 on the growth (body length) and reproduction (brood size, generation time and morphology of gonad arm) can be transmitted through generations...
March 13, 2024: Food and Chemical Toxicology
https://read.qxmd.com/read/38490314/sirtuin-1-in-osteoarthritis-perspectives-on-regulating-glucose-metabolism
#8
REVIEW
Zhihao Liao, Xuepei Cai, Yifan Zheng, Jiayu Lin, Xia Yang, Weiyin Lin, Ying Zhang, Xin He, Chufeng Liu
Osteoarthritis (OA) is a degenerative disease characterised by articular cartilage destruction, and its complex aetiology contributes to suboptimal clinical treatment outcomes. A close association exists between glucose metabolism dysregulation and OA pathogenesis. Owing to the unique environment of low oxygen and glucose concentrations, chondrocytes rely heavily on their glycolytic capacity, exhibiting distinct spatiotemporal differences. However, under pathological stimulation, chondrocytes undergo excessive glycolytic activity while mitochondrial respiration and other branches of glucose metabolism are compromised...
March 13, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38490065/simple-method-for-isolation-and-culture-of-primary-buffalo-bubalus-bubalis-endometrial-epithelial-cells-pbueecs-and-its-characterization-using-high-throughput-proteomics-approach
#9
JOURNAL ARTICLE
Shradha Jamwal, Nikunj Tyagi, Jaideep Kumar, Jai Kumar Kaushik, Sudarshan Kumar, Ashok Kumar Mohanty
Early embryonic mortality resulting from insufficient interaction between the embryo and the uterus leads to the failure of pregnancy in livestock animals. Thus, it is imperative to comprehend the multifaceted process of implantation at molecular levels, which requires synchronized feto-maternal interaction. The in-vitro models serve as valuable tools to investigate the specific stages of implantation. The present study was undertaken to develop a simple method to isolate and culture the primary buffalo endometrial epithelial cells (pBuEECs), followed by proteome profiling of the proliferating cells...
February 29, 2024: Animal Reproduction Science
https://read.qxmd.com/read/38489847/corn-oligopeptide-alleviates-nonalcoholic-fatty-liver-disease-by-regulating-the-sirtuin-signaling-pathway
#10
JOURNAL ARTICLE
Yali Xu, Ting Su, Hricha Mishra, Reiko Ando, Yutaka Furutani, Jun Lu, Muyi Cai, Harukazu Suzuki, Wenkui Yu, Xian-Yang Qin
Nonalcoholic fatty liver disease (NAFLD) represents the most prevalent type of chronic liver disease, spanning from simple steatosis to nonalcoholic steatohepatitis (NASH). Corn oligopeptide (CP) is a functional peptide known for its diverse pharmacological effects on metabolism. In this study, we evaluated the protective activity of CP against fatty liver disease. Oral administration of CP significantly reduced body weight gain by 2.95%, serum cholesterol by 22.54%, and liver injury, as evidenced by a reduction of 32...
March 15, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38489668/boosting-energy-deprivation-by-synchronous-interventions-of-glycolysis-and-oxidative-phosphorylation-for-bioenergetic-therapy-synergetic-with-chemodynamic-photothermal-therapy
#11
JOURNAL ARTICLE
Xiangjun Wei, Renlu Han, Yun Gao, Pengxin Song, Zhen Guo, Yafei Hou, Jiancheng Yu, Keqi Tang
Bioenergetic therapy is emerging as a promising therapeutic approach. However, its therapeutic effectiveness is restricted by metabolic plasticity, as tumor cells switch metabolic phenotypes between glycolysis and oxidative phosphorylation (OXPHOS) to compensate for energy. Herein, Metformin (MET) and BAY-876 (BAY) co-loaded CuFe2 O4 (CF) nanoplatform (CFMB) is developed to boost energy deprivation by synchronous interventions of glycolysis and OXPHOS for bioenergetic therapy synergetic with chemodynamic/photothermal therapy (CDT/PTT)...
March 15, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38489361/-s-nitrosylation-of-a-receptor-like-cytoplasmic-kinase-regulates-plant-immunity
#12
JOURNAL ARTICLE
Beimi Cui, Qiaona Pan, Wenqiang Cui, Yiqin Wang, Verity I P Loake, Shuguang Yuan, Fengquan Liu, Gary J Loake
Perception of pathogen/microbial-associated molecular patterns (P/MAMPs) by plant cell surface receptors leads to a sustained burst of reactive oxygen species (ROS), a key feature of P/MAMP-triggered immunity (PTI). Here we report that P/MAMP recognition leads to a rapid nitrosative burst, initiating the accumulation of nitric oxide (NO), subsequently leading to S -nitrosylation of the receptor-like cytoplasmic kinase (RLCK), botrytis-induced kinase 1 (BIK1), at Cys80 . This redox-based, posttranslational modification, promotes the phosphorylation of BIK1, subsequently resulting in BIK1 activation and stabilization...
March 15, 2024: Science Advances
https://read.qxmd.com/read/38488552/metabolic-reprogramming-of-the-inflammatory-response-in-the-nervous-system-the-crossover-between-inflammation-and-metabolism
#13
JOURNAL ARTICLE
Jesus Amo-Aparicio, Charles A Dinarello, Ruben Lopez-Vales
Metabolism is a fundamental process by which biochemicals are broken down to produce energy (catabolism) or used to build macromolecules (anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate multiple cellular responses. This was first identified in cancer cells as the Warburg effect, but it is also present in immunocompetent cells. Studies have revealed a bidirectional influence of cellular metabolism and immune cell function, highlighting the significance of metabolic reprogramming in immune cell activation and effector functions...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38487001/targeting-the-warburg-effect-a-revisited-perspective-from-molecular-mechanisms-to-traditional-and-innovative-therapeutic-strategies-in-cancer
#14
REVIEW
Minru Liao, Dahong Yao, Lifeng Wu, Chaodan Luo, Zhiwen Wang, Jin Zhang, Bo Liu
Cancer reprogramming is an important facilitator of cancer development and survival, with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation, even under sufficient oxygen supply condition. This metabolic alteration, known as the Warburg effect, serves as a significant indicator of malignant tumor transformation. The Warburg effect primarily impacts cancer occurrence by influencing the aerobic glycolysis pathway in cancer cells. Key enzymes involved in this process include glucose transporters (GLUTs), HKs, PFKs, LDHs, and PKM2...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38485443/mechanisms-of-harmful-effects-of-microcystis-aeruginosa-on-a-brackish-water-organism-moina-mongolica-based-on-physiological-and-transcriptomic-responses
#15
JOURNAL ARTICLE
Hongtao Liu, Hao Xing, Zhangyi Xia, Tingting Wu, Jinlin Liu, Aiqin Li, Fangling Bi, Yuqing Sun, Jianheng Zhang, Peimin He
To investigate the detrimental impacts of cyanobacterial bloom, specifically Microcystis aeruginosa, on brackish water ecosystems, the study used Moina mongolica, a cladoceran species, as the test organism. In a chronic toxicology experiment, the survival and reproductive rates of M. mongolica were assessed under M. aeruginosa stress. It was observed that the survival rate of M. mongolica fed with M. aeruginosa significantly decreased with time and their reproduction rate dropped to zero, while the control group remained maintained stable and normal reproduction...
March 2024: Harmful Algae
https://read.qxmd.com/read/38485285/resolvins-protect-against-diabetes-induced-colonic-oxidative-stress-barrier-dysfunction-and-associated-diarrhea-via-the-ho-1-pathway
#16
JOURNAL ARTICLE
Ting Yu, Die Chen, Hongyan Qi, Lin Lin, Yurong Tang
Diabetes is associated with increased oxidative stress, leading to altered tight junction formation and increased apoptosis in colonic epithelial cells. These changes may lead to intestinal barrier dysfunction and corresponding gastrointestinal symptoms in patients with diabetes, including diarrhea. The aim of this study was to characterize the effect and mechanism of Resolvin D1 (RvD1) on diabetes-induced oxidative stress and barrier disruption in the colon. Mice with streptozotocin-induced diabetes were treated with RvD1 for 2 weeks, then evaluated for stool frequency, stool water content, gut permeability, and colonic transepithelial electrical resistance as well as production of reactive oxygen species (ROS), apoptosis, and expression of tight junction proteins Zonula Occludens 1 (ZO-1) and occludin...
March 14, 2024: BioFactors
https://read.qxmd.com/read/38485266/a-serine-metabolic-enzyme-is-flexing-its-muscle-to-help-repair-skeletal-muscle
#17
REVIEW
Benjámin R Baráth, Laszlo Nagy
Metabolic reprogramming of stem cells is a targetable pathway to control regeneration. Activation of stem cells results in down-regulation of oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) and turns on glycolysis to provide fuel for proliferation and specific signaling events. How cell type-specific events are regulated is unknown. In this issue of Genes & Development Ciuffoli and colleagues (pp. XXX-XXX) use metabolomic, gene inactivation, and functional approaches to show that phosphoserine aminotransferase (Psat1), an enzyme in serine biosynthesis, is activated in muscle stem cells and contributes to cell expansion and skeletal muscle regeneration via the production of α-ketoglutarate and glutamine...
March 14, 2024: Genes & Development
https://read.qxmd.com/read/38485044/roles-of-heat-shock-protein-a12a-in-the-development-of-diabetic-cardiomyopathy
#18
JOURNAL ARTICLE
Yunxiao Jia, Yunhao Yu, Chenxi Gao, Yuehua Li, Chuanfu Li, Zhengnian Ding, Qiuyue Kong, Li Liu
Long-term hyperglycemia can lead to diabetic cardiomyopathy (DCM), a main lethal complication of diabetes. However, the mechanisms underlying DCM development have not been fully elucidated. Heat shock protein A12A (HSPA12A) is the atypic member of HSP70 family. In the present study, we found that the expression of HSPA12A was upregulated in hearts of mice with streptozotocin (STZ)-induced diabetes, while ablation of HSPA12A improved cardiac systolic and diastolic dysfunction and increased cumulative survival of diabetic mice...
March 12, 2024: Cell Stress & Chaperones
https://read.qxmd.com/read/38484898/piperine-attenuates-hepatic-ischemia-reperfusion-injury-via-suppressing-the-tlr4-signaling-cascade-in-mice
#19
JOURNAL ARTICLE
Lidan Zhang, Ge Kuang, Xia Gong, Rui Huang, Zizuo Zhao, Yan Li, Jingyuan Wan, Bin Wang
Piperine, the major active substance in black pepper, has been shown to have anti-inflammatory and antioxidant effects in several ischemic diseases. However, the role of piperine in hepatic ischemia/reperfusion injury (HIRI) and its underlying mechanisms remain unclear. In this study, the mice were administered piperine (30 mg/kg) intragastric administration before surgery. After 24 h of hepatic ischemia-reperfusion, liver histopathological evaluation, serum transaminase measurements, and TUNEL analysis were performed...
March 12, 2024: Transplant Immunology
https://read.qxmd.com/read/38484369/a-comprehensive-investigation-on-the-receptor-bsg-expression-reveals-the-potential-risk-of-healthy-individuals-and-cancer-patients-to-2019-ncov-infection
#20
JOURNAL ARTICLE
Yongbiao Huang, Haiting Zhou, Yuan Wang, Lingyan Xiao, Wan Qin, Long Li
BACKGROUND: Coronavirus disease-2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a newly emerging coronavirus. BSG (basigin) is involved in the tumorigenesis of multiple tumors and recently emerged as a novel viral entry receptor for SARS-CoV-2. However, its expression profile in normal individuals and cancer patients are still unclear. METHODS: We performed a comprehensive analysis of the expression and distribution of BSG in normal tissues, tumor tissues, and cell lines via bioinformatics analysis and experimental verification...
March 13, 2024: Aging
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