keyword
MENU ▼
Read by QxMD icon Read
search

AOX

keyword
https://www.readbyqxmd.com/read/28328295/electrochemical-treatment-of-tannery-wastewater-raw-coagulated-and-pretreated-by-aops
#1
Jeremi H Naumczyk, Małgorzata A Kucharska
This study on tannery wastewater treatment showed that indirect electrooxidation by chlorine generated at a Ti/SnO2/PdO2/RuO2 (SPR) anode led to full ammonia removal, and a decrease in chemical oxygen demand (COD) of up to 77.0%. A combined process of coagulation + H2O2/UV + electrooxidation allowed us to achieve a decrease in COD of up to 97.5%. Equations describing the kinetics of the decrease in COD, the relationship between the decrease in COD and current, and the relationship between the current efficiency of COD reduction and the initial concentrations of the reagents were established...
March 22, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28302114/implications-of-evolutionary-engineering-for-growth-and-recombinant-protein-production-in-methanol-based-growth-media-in-the-yeast-pichia-pastoris
#2
Josef W Moser, Roland Prielhofer, Samuel M Gerner, Alexandra B Graf, Iain B H Wilson, Diethard Mattanovich, Martin Dragosits
BACKGROUND: Pichia pastoris is a widely used eukaryotic expression host for recombinant protein production. Adaptive laboratory evolution (ALE) has been applied in a wide range of studies in order to improve strains for biotechnological purposes. In this context, the impact of long-term carbon source adaptation in P. pastoris has not been addressed so far. Thus, we performed a pilot experiment in order to analyze the applicability and potential benefits of ALE towards improved growth and recombinant protein production in P...
March 17, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28277962/oxidative-challenges-of-avian-migration-a-comparative-field-study-on-a-partial-migrant
#3
Cas Eikenaar, Emma Källstig, Martin N Andersson, Amparo Herrera-Dueñas, Caroline Isaksson
Most avian migrants alternate flight bouts, characterized by high metabolic rates, with stopovers, periods of fuel replenishment through hyperphagia. High-energy metabolism and excessive calorie intake shift the balance between damaging prooxidants and antioxidants toward the former. Hence, migration likely affects the oxidative balance of birds. Migratory flight indeed appears to cause oxidative damage; however, whether migration affects the oxidative state of birds at stopover is unclear. Therefore, we compared total nonenzymatic antioxidant capacity (AOX) and malondialdehyde concentration (MDA; a measure of lipid peroxidation) in the plasma of migrant and resident common blackbirds...
March 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28263602/aldehyde-oxidase-mediated-metabolism-in-drug-like-molecules-a-combined-computational-and-experimental-study
#4
Yuan Xu, Liang Li, Yulan Wang, Jing Xing, Lei Zhou, Dafang Zhong, Xiaomin Luo, Hualiang Jiang, Kaixian Chen, Mingyue Zheng, Pan Deng, Xiaoyan Chen
Aldehyde oxidase (AOX) is an important drug-metabolizing enzyme. However, the current in vitro models for evaluating AOX metabolism are sometimes misleading, and preclinical animal models generally fail to predict human AOX-mediated metabolism. In this study, we report a combined computational and experimental investigation of drug-like molecules that are potential aldehyde oxidase substrates, of which multiple sites of metabolism (SOMs) mediated by AOX and their preferences for the reaction can be unambiguously identified...
March 6, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28254035/aox-contamination-status-and-genotoxicity-of-aox-bearing-pharmaceutical-wastewater
#5
Yawei Xie, Lujun Chen, Rui Liu
Adsorbable organic halogens (AOX) are a general indicator for the total amount of compounds containing organically bonded halogens. AOX concentrations and components were investigated along the wastewater treatment process in four large-scale pharmaceutical factories of China, and genotoxicity based on the SOS/umu test was also evaluated. The results showed that AOX concentrations in wastewater of four factories ranged from 4.6 to 619.4mg/L, which were high but greatly different owing to differences in the raw materials and products...
February 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28249567/a-reference-gene-set-for-sex-pheromone-biosynthesis-and-degradation-genes-from-the-diamondback-moth-plutella-xylostella-based-on-genome-and-transcriptome-digital-gene-expression-analyses
#6
Peng He, Yun-Fei Zhang, Duan-Yang Hong, Jun Wang, Xing-Liang Wang, Ling-Hua Zuo, Xian-Fu Tang, Wei-Ming Xu, Ming He
BACKGROUND: Female moths synthesize species-specific sex pheromone components and release them to attract male moths, which depend on precise sex pheromone chemosensory system to locate females. Two types of genes involved in the sex pheromone biosynthesis and degradation pathways play essential roles in this important moth behavior. To understand the function of genes in the sex pheromone pathway, this study investigated the genome-wide and digital gene expression of sex pheromone biosynthesis and degradation genes in various adult tissues in the diamondback moth (DBM), Plutella xylostella, which is a notorious vegetable pest worldwide...
March 1, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28237113/assays-to-monitor-pexophagy-in-yeast
#7
W Wang, S Subramani
Pexophagy is a selective autophagy process that degrades damaged and/or superfluous peroxisomes in the yeast vacuole or in mammalian lysosomes. The molecular mechanisms of pexophagy are well studied in yeast. Peroxisomes can be rapidly induced by oleate in the budding yeast, Saccharomyces cerevisiae, and by oleate or methanol in the methylotrophic yeast, Pichia pastoris. A number of peroxisomal matrix enzymes, such as 3-ketoacyl CoA thiolase (thiolase) and alcohol oxidase (AOX), are upregulated correspondingly to meet metabolic demands of the cells...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28226194/melatonin-systemically-ameliorates-drought-stress-induced-damage-in-medicago-sativa-plants-by-modulating-nitro-oxidative-homeostasis-and-proline-metabolism
#8
Chrystalla Antoniou, Giannis Chatzimichail, Rafaella Xenofontos, Giannis Pavlou, Evangelia Panagiotou, Anastasis Christou, Vasileios Fotopoulos
Recent reports have uncovered the multifunctional role of melatonin in plant physiological responses under optimal and sub-optimal environmental conditions. In this study, we explored whether melatonin pretreatment could provoke priming effects in alfalfa (Medicago sativa L.) plants subsequently exposed to prolonged drought stress (7 days), by withholding watering. Results revealed that the rhizospheric application of melatonin (10 μM) remarkably enhanced the drought tolerance of alfalfa plants, as evidenced by the observed plant tolerant phenotype, as well as by the higher levels of chlorophyll fluorescence and stomatal conductance, compared with non-treated drought-stressed plants...
February 22, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28193355/a-paper-based-nanomodified-electrochemical-biosensor-for-ethanol-detection-in-beers
#9
Stefano Cinti, Mattia Basso, Danila Moscone, Fabiana Arduini
Herein, we report the first example of a paper-based screen-printed biosensor for the detection of ethanol in beer samples. Common office paper was adopted to fabricate the analytical device. The properties of this paper-based screen-printed electrode (SPE) were investigated by cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy, and they were compared with the well-established polyester-based SPEs as well. Paper demonstrated similar properties when compared with polyester, highlighting suitability towards its utilization in sensor development, with the advantages of low cost and simple disposal by incineration...
April 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28126656/structural-basis-for-the-role-of-mammalian-aldehyde-oxidases-in-the-metabolism-of-drugs-and-xenobiotics
#10
REVIEW
Maria João Romão, Catarina Coelho, Teresa Santos-Silva, Alessandro Foti, Mineko Terao, Enrico Garattini, Silke Leimkühler
Aldehyde oxidases (AOXs) are molybdo-flavoenzymes characterized by broad substrate specificity, oxidizing aromatic/aliphatic aldehydes into the corresponding carboxylic acids and hydroxylating various heteroaromatic rings. Mammals are characterized by a complement of species-specific AOX isoenzymes, that varies from one in humans (AOX1) to four in rodents (AOX1, AOX2, AOX3 and AOX4). The physiological function of mammalian AOX isoenzymes is unknown, although human AOX1 is an emerging enzyme in phase-I drug metabolism...
January 23, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28095715/an-overview-of-aldehyde-oxidase-an-enzyme-of-emerging-importance-in-novel-drug-discovery
#11
Mohammad-Reza Rashidi, Somaieh Soltani
Given the rising trend in medicinal chemistry strategy to reduce cytochrome P450-dependent metabolism, aldehyde oxidase (AOX) has recently gained increased attention in drug discovery programs and the number of drug candidates that are metabolized by AOX is steadily growing. Areas covered: Despite the emerging importance of AOX in drug discovery, there are certain major recognized problems associated with AOX-mediated metabolism of drugs. Intra- and inter-species variations in AOX activity, the lack of reliable and predictive animal models using the common experimental animals, and failure in the predictions of in vivo metabolic activity of AOX using traditional in vitro methods are among these issues that are covered in this article...
February 6, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28088750/continuous-minimally-invasive-alcohol-monitoring-using-microneedle-sensor-arrays
#12
A M Vinu Mohan, Joshua Ray Windmiller, Rupesh K Mishra, Joseph Wang
The present work describes an attractive skin-worn microneedle sensing device for the minimally invasive electrochemical monitoring of subcutaneous alcohol. The device consists of an assembly of pyramidal microneedle structures integrated with Pt and Ag wires, each with a microcavity opening. The microneedle aperture was modified by electropolymerizing o-phenylene diamine onto the Pt wire microtransducer, followed by the immobilization of alcohol oxidase (AOx) in an intermediate chitosan layer, along with an outer Nafion layer...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28088729/new-insights-into-aox2-transcriptional-regulation-in-chlamydomonas-reinhardtii
#13
Mariya Ostroukhova, Zhanneta Zalutskaya, Elena Ermilova
A feature of the mitochondrial electron transport chain in plants, some protists and many fungi is the presence of two terminal oxidases, the energy-conserving cytochrome oxidase and another termed alternative oxidase (AOX). AOX branches from the main respiratory chain, directly coupling the oxidation of ubiquinol with reduction of oxygen to water. The AOX genes can be divided into two discrete subfamilies, AOX1 and AOX2. Although AOX has been proposed to play essential roles in stress tolerance of organisms, the role of subfamily AOX2 is largely unknown...
December 13, 2016: European Journal of Protistology
https://www.readbyqxmd.com/read/28081503/in-silico-identification-of-alternative-oxidase-2-aox2-in-monocots-a-new-evolutionary-scenario
#14
José Hélio Costa, Clesivan Pereira Dos Santos, Beatriz de Sousa E Lima, Anthônio Nunes Moreira Netto, Kátia Daniella da Cruz Saraiva, Birgit Arnholdt-Schmitt
We identified AOX2 genes in monocot species from Lemnoideae (Spirodela polyrhiza, Lemna gibba and Landoltia punctata), Pothoideae (Anthurium andraeanum and Anthurium amnicola) and Monsteroideae (Epipremnum aureum) subfamilies within the Araceae, an early-diverging monocot family. These findings highlight the presence of AOX2 in the most ancient monocot ancestor and also that at least partial loss of this gene occurred during speciation events within several monocot orders. The presence of AOX2 in monocot species challenges (1) new understanding of the evolutionary history of the AOX gene family in angiosperms and (2) drives experimental and bioinformatics efforts to explore functional relevance of the two AOX gene family members for plant growth and development...
December 27, 2016: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28077780/editor-s-highlight-exposure-to-crvi-during-early-pregnancy-increases-oxidative-stress-and-disrupts-the-expression-of-antioxidant-proteins-in-placental-compartments
#15
Sakhila K Banu, Jone A Stanley, Kirthiram K Sivakumar, Robert J Taylor, Joe A Arosh, Robert C Burghardt
Epidemiologic studies document relationships between chromium VI (CrVI) exposure and increased risk of spontaneous abortion, stillbirth, preterm birth, and neonatal death in pregnant women. Environmental contamination with CrVI is a growing problem both in the United States and developing countries. CrVI is widely used in numerous industries. This study was designed to understand the mechanism of CrVI toxicity on placental oxidative stress and antioxidant (AOX) machinery. Pregnant mother rats were treated with or without CrVI (50 ppm K2Cr2O7) through drinking water from gestational day (GD) 9...
February 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28067626/broad-aox-expression-in-a-genetically-tractable-mouse-model-does-not-disturb-normal-physiology
#16
Marten Szibor, Praveen K Dhandapani, Eric Dufour, Kira M Holmström, Yuan Zhuang, Isabelle Salwig, Ilka Wittig, Juliana Heidler, Zemfira Gizatullina, Timur Gainutdinov, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Jatin Nandania, Vidya Velagapudi, Astrid Wietelmann, Pierre Rustin, Frank N Gellerich, Howard T Jacobs, Thomas Braun
Plants and many lower organisms, but not mammals, express alternative oxidases (AOXs) that branch the mitochondrial respiratory chain, transferring electrons directly from ubiquinol to oxygen without proton pumping. Thus, they maintain electron flow under conditions when the classical respiratory chain is impaired, limiting excess production of oxygen radicals and supporting redox and metabolic homeostasis. AOX from Ciona intestinalis has been used to study and mitigate mitochondrial impairments in mammalian cell lines, Drosophila disease models and, most recently, in the mouse, where multiple lentivector-AOX transgenes conferred substantial expression in specific tissues...
February 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28063701/physicochemical-characterization-of-atlantic-canadian-seafood-processing-plant-effluent
#17
Bryan Lee Jamieson, Graham A Gagnon, Alex Augusto Gonçalves
The purpose of this study was to conduct a preliminary assessment of the potential impacts of Atlantic Canadian seafood processing effluents on the aquatic environment through physical-chemical characterization. Shellfish and finfish effluent samples were collected and characterized by biochemical oxygen demand (BOD5), chemical oxygen demand (COD), turbidity, total suspended solids (TSS), ammonia nitrogen (NH3-N), adsorbable organic halides (AOX), soluble BOD5 and soluble COD. Effluent concentration ranges were BOD5 (179 to 276mgL(-1)), COD (458 to 1717mgL(-1)), turbidity (28...
January 4, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28060946/high-osmolarity-environments-activate-the-mitochondrial-alternative-oxidase-in-debaryomyces-hansenii
#18
Wilson Garcia-Neto, Alfredo Cabrera-Orefice, Salvador Uribe-Carvajal, Alicia J Kowaltowski, Luis Alberto Luévano-Martínez
The oleaginous yeast Debaryomyces hansenii is a good model to understand molecular mechanisms involved in halotolerance because of its impressive ability to survive under a wide range of salt concentrations. Several cellular adaptations are implicated in this response, including the presence of a cyanide-insensitive ubiquinol oxidase (Aox). This protein, which is present in several taxonomical orders, has been related to different stress responses. However, little is known about its role in mitochondria during transitions from low to high saline environments...
2017: PloS One
https://www.readbyqxmd.com/read/28039507/production-and-characteristics-of-the-recombinant-extracellular-bifunctional-endoglucanase-of-the-polyextremophilic-bacterium-bacillus-halodurans-and-its-applicability-in-saccharifying-agro-residues
#19
Ranjitha R Prabhu, Deepak Parashar, T Satyanarayana
The recombinant alkalistable and moderately thermostable bifunctional endoglucanase gene (BhCell-Xyl) of polyextremophilic bacterium Bacillus halodurans TSLV1 has been expressed in Pichia pastoris under constitutive GAP as well as inducible AOX promoters. A higher titre of recombinant BhCell-Xyl was attained after induction (4.8 U mL(-1)) as compared to that of the constitutive production (2.1 U mL(-1)). The recombinant P. pastoris strains integrated two copies of BhCell-Xyl under AOX and GAP promoters...
December 30, 2016: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28024235/implications-of-terminal-oxidase-function-in-regulation-of-salicylic-acid-on-soybean-seedling-photosynthetic-performance-under-water-stress
#20
Yanping Tang, Xin Sun, Tao Wen, Mingjie Liu, Mingyan Yang, Xuefei Chen
The aim of this study is to investigate whether exogenous application of salicylic acid (SA) could modulate the photosynthetic capacity of soybean seedlings in water stress tolerance, and to clarify the potential functions of terminal oxidase (plastid terminal oxidase (PTOX) and alternative oxidase (AOX)) in SA' s regulation on photosynthesis. The effects of SA and water stress on gas exchange, pigment contents, chlorophyll fluorescence, enzymes (guaiacol peroxidase (POD; EC 1.11.1.7), superoxide dismutase (SOD; EC 1...
November 25, 2016: Plant Physiology and Biochemistry: PPB
keyword
keyword
47892
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"