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https://www.readbyqxmd.com/read/29350428/meta-analysis-of-fish-early-life-stage-tests-association-of-toxic-ratios-and-acute-to-chronic-ratios-with-modes-of-action
#1
REVIEW
Stefan Scholz, Rene Schreiber, James Armitage, Philipp Mayer, Beate I Escher, Annegret Lidzba, Marc Léonard, Rolf Altenburger
Fish early life stage (FELS) tests (OECD test guideline 210) are widely conducted to estimate chronic fish toxicity. In these tests, fish are exposed from the embryonic to the juvenile life stage. In order to analyse whether certain modes of action are related to high toxic ratios (TR, i.e., ratios between experimental effect and baseline toxicity) and/or acute-to-chronic ratios (ACR) in the FELS test effect concentrations for 183 compounds were extracted from the US EPA ecotoxicity database. Analysis of effect concentration of narcotic compounds indicated that baseline toxicity could be observed in the FELS test at similar concentrations as in acute fish toxicity test...
January 19, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29350421/involvement-of-xanthine-oxidase-inhibition-with-the-antioxidant-property-of-nanoencapsulated-melaleuca-alternifolia-essential-oil-in-fish-experimentally-infected-with-pseudomonas-aeruginosa
#2
M D Baldissera, C F Souza, P H Doleski, R C V Santos, R P Raffin, B Baldisserotto
Nanoencapsulated Melaleuca alternifolia essential oil (tea tree oil, TTO) is a natural alternative treatment, with 100% therapeutic efficacy in fish experimentally infected with Pseudomonas aeruginosa, and has also potent protective effects linked with antioxidant properties. However, the pathways responsible for the antioxidant capacity remain unknown. Thus, this study evaluated whether the inhibition of seric xanthine oxidase (XO) activity can be considered a pathway involved in the antioxidant capacity of nanoencapsulated TTO in fish experimentally infected with P...
January 19, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29343955/lysyl-oxidase-activates-cancer-stromal-cells-and-promotes-gastric-cancer-progression-quantum-dot-based-identification-of-biomarkers-in-cancer-stromal-cells
#3
Chunwei Peng, Jiuyang Liu, Guifang Yang, Yan Li
Purpose: Semiconductor quantum dots (QDs) are a promising alternative to organic fluorescent dyes for multiplexed molecular imaging of cancer stroma, which have great advantages in holistically analyzing the complex interactions among cancer stromal components in situ. Patients and methods: A QD probe-based multiplexed spectral molecular imaging method was established for simultaneous imaging. Three tissue microarrays (TMAs) including 184 gastric cancer (GC) tissues were constructed for the study...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29339106/safinamide-a-new-hope-for-parkinson-s-disease
#4
REVIEW
Fábio G Teixeira, Miguel F Gago, Paulo Marques, Pedro Silva Moreira, Ricardo Magalhães, Nuno Sousa, António J Salgado
The loss of dopaminergic neurons (DAn) and reduced dopamine (DA) production underlies the reasoning behind the gold standard treatment for Parkinson's disease (PD) using levodopa (L-DOPA). Recently licensed by the European Medicine Agency (EMA) and US Food and Drug Administration (FDA), safinamide [a monoamine oxidase B (MOA-B) inhibitor] is an alternative to L-DOPA; as we discuss here, it enhances dopaminergic transmission with decreased secondary effects compared with L-DOPA. In addition, nondopaminergic actions (neuroprotective effects) have been reported, with safinamide inhibiting glutamate release and sodium/calcium channels, reducing the excitotoxic input to dopaminergic neuronal death...
January 12, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29331679/molecular-identification-of-forensically-important-calliphoridae-and-sarcophagidae-species-using-its2-nucleotide-sequences
#5
Ji Hye Park, Yu-Hoon Kim, Chan Seon Ham, Sang Eon Shin, Hyun Ju Lee, Kwang Soo Ko, Jinhyuk Choi, Gi Hoon Son, Seong Hwan Park
The application of insect evidence to forensic investigations is mainly based on the estimation of postmortem interval and the identification of insect species from samples that are collected from the crime scene. Due to the limited number of expert taxonomists, species identification is one of the major barriers for crime scene investigators to utilize forensic entomology. Therefore, the molecular identification of species, using mitochondrial cytochrome c oxidase subunit I (COI) gene, has been suggested as an alternative strategy...
January 3, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29327206/brain-photobiomodulation-therapy-a-narrative-review
#6
REVIEW
Farzad Salehpour, Javad Mahmoudi, Farzin Kamari, Saeed Sadigh-Eteghad, Seyed Hossein Rasta, Michael R Hamblin
Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological conditions. Red/NIR light is able to stimulate complex IV of the mitochondrial respiratory chain (cytochrome c oxidase) and increase ATP synthesis. Moreover, light absorption by ion channels results in release of Ca2+ and leads to activation of transcription factors and gene expression. Brain PBM therapy enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and antioxidant responses, as well as neurogenesis and synaptogenesis...
January 11, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29323892/same-substrate-many-reactions-oxygen-activation-in-flavoenzymes
#7
Elvira Romero, J Rubén Gómez Castellanos, Giovanni Gadda, Marco W Fraaije, Andrea Mattevi
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by modulating the reactivity of their cofactors. Flavins are extremely versatile cofactors that are capable of undergoing redox reactions by accepting either one electron or two electrons, alternating between the oxidized and the reduced states. The physical and chemical principles of flavin-based chemistry have been investigated widely. In the following pages we summarize the state of the art on a key area of research in flavin enzymology: the molecular basis for the activation of O2 by flavin-dependent oxidases and monooxygenases...
January 11, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29310704/mapping-insecticide-resistance-in-anopheles-gambiae-s-l-from-c%C3%A3-te-d-ivoire
#8
Soromane Camara, Alphonsine A Koffi, Ludovic P Ahoua Alou, Kouakou Koffi, Jean-Paul K Kabran, Aboubacar Koné, Mathieu F Koffi, Raphaël N'Guessan, Cédric Pennetier
BACKGROUND: Insecticide resistance in malaria vectors is an increasing threat to vector control tools currently deployed in endemic countries. Resistance management must be an integral part of National Malaria Control Programmes' (NMCPs) next strategic plans to alleviate the risk of control failure. This obviously will require a clear database on insecticide resistance to support the development of such a plan. The present work gathers original data on insecticide resistance between 2009 and 2015 across Côte d'Ivoire in West Africa...
January 8, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29306187/the-ellagitannin-het-induces-electrolyte-leakage-calcium-influx-and-the-accumulation-of-nitric-oxide-and-hydrogen-peroxide-in-strawberry
#9
Gustavo Gabriel Martos, Alicia Mamaní, María Paula Filippone, Atilio Pedro Castagnaro, Juan Carlos Díaz Ricci
HeT (1-0-galloyl-2,3; 4,6-bis-hexahydroxydiphenoyl-β-D-glucopyranose) is a penta-esterified ellagitannin obtained from strawberry leaves. Previous studies have shown that foliar application of HeT prior to inoculation with a virulent pathogen increases the resistance toward Colletotrichum acutatum in strawberry plants and to Xanthomonas citri subsp. citri in lemon plants. In this work we report that HeT induces an immediate leak of electrolytes, the hyperpolarization of the cellular membrane, a rapid Ca2+ influx to the cytoplasm during the first few seconds, which in turn modulates the accumulation of nitric oxide 5 min after treatment...
December 27, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29298911/slow-domain-reconfiguration-causes-power-law-kinetics-in-a-two-state-enzyme
#10
Iris Grossman-Haham, Gabriel Rosenblum, Trishool Namani, Hagen Hofmann
Protein dynamics are typically captured well by rate equations that predict exponential decays for two-state reactions. Here, we describe a remarkable exception. The electron-transfer enzyme quiescin sulfhydryl oxidase (QSOX), a natural fusion of two functionally distinct domains, switches between open- and closed-domain arrangements with apparent power-law kinetics. Using single-molecule FRET experiments on time scales from nanoseconds to milliseconds, we show that the unusual open-close kinetics results from slow sampling of an ensemble of disordered domain orientations...
January 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29288587/from-lab-to-market-an-integrated-bioprocess-design-approach-for-new-to-nature-biosurfactants-produced-by-starmerella-bombicola
#11
Lisa Van Renterghem, Sophie L K W Roelants, Niki Baccile, Katrijn Uyttersprot, Marie Claire Taelman, Bernd Everaert, Stein Mincke, Sam Ledegen, Sam Debrouwer, Kristel Scholtens, Christian Stevens, Wim Soetaert
Glycolipid microbial biosurfactants, like sophorolipids (SLs), generate high industrial interest as 100% biobased alternatives for traditional surfactants. A well-known success story is the efficient SL producer Starmerella bombicola, which reaches titers well above 200 g/L. Recent engineering attempts have enabled the production of completely new types of molecules by S. bombicola, like the 'non-symmetrical bolaform (nsBola) SLs'. As classic SLs are mostly applied in eco-friendly detergents, the possible use of these bolaform SLs in detergent applications was evaluated by scaling up the production process (150 L) and evaluating the purified product...
December 30, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29281082/improved-chloroplast-energy-balance-during-water-deficit-enhances-plant-growth-more-crop-per-drop
#12
Keshav Dahal, Greg C Vanlerberghe
The non-energy conserving alternative oxidase (AOX) respiration of plant mitochondria is known to interact with chloroplast photosynthesis. This may have consequences for growth, particularly under sub-optimal conditions when energy imbalances can impede photosynthesis. This hypothesis was tested by comparing the metabolism and growth of wild-type (WT) Nicotiana tabacum with that of AOX knockdown and overexpression lines during a prolonged steady-state mild to moderate water deficit. Under moderate water deficit, AOX amount was an important determinant of the rate of both mitochondrial respiration in the light and net photosynthetic CO2 assimilation (A) at the growth irradiance...
December 21, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29274496/new-world-spittlebugs-hemiptera-cercopidae-ischnorhininae-dated-molecular-phylogeny-classification-and-evolution-of-aposematic-coloration
#13
Andressa Paladini, Daniela M Takiya, Julie M Urban, Jason R Cryan
The spittlebug family Cercopidae (Hemiptera: Auchenorrhyncha: Cicadomorpha: Cercopoidea) is distributed worldwide, with highest species diversity in the tropics. Several included species are economically important pests of major agricultural crops and cultivated pasture grasses. Taxonomically, Cercopidae is divided into two subfamilies: the paraphyletic Old World Cercopinae and the monophyletic New World Ischnorhininae. Results are here presented from an investigation of phylogenetic relationships within Ischnorhininae based on DNA sequences from seven loci (18S rDNA, 28S rDNA, Histone 2A, Histone 3, Wingless, Cytochrome Oxidase I, and Cytochrome Oxidase II) generated from exemplars of 119 spittlebug species...
December 20, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29258710/consolidated-bioprocessing-for-sodium-gluconate-production-from-cellulose-using-penicillium-oxalicum
#14
Xiaolong Han, Guodong Liu, Yunjun Pan, Wenxia Song, Yinbo Qu
The feasibility of consolidated bioprocessing for sodium gluconate production from cellulose was studied. A recombinant strain named z19 was constructed from Penicillium oxalicum wild-type strain 114-2 for simultaneous expression of glucose oxidase and catalase from Aspergillus niger. While keeping a cellulolytic ability similar with that of 114-2, z19 secreted certain amounts of glucose oxidase and catalase. Fed-batch and two-stage temperature control strategy (0-120 h, 30 °C; 120-192 h, 45 °C) was utilized for sodium gluconate production from cellulose (filter paper power), with 13...
December 13, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29224627/metabolic-engineering-of-escherichia-coli-for-acetaldehyde-overproduction-using-pyruvate-decarboxylase-from-zymomonas-mobilis
#15
Balaji Balagurunathan, Lily Tan, Hua Zhao
For the sustainable production of acetaldehyde, a key raw-material for a large number of chemical products, microbial production is a promising alternative. We have engineered an Escherichia coli strain for acetaldehyde production from glucose by introducing the pyruvate decarboxylase (Pdc) from Zymomonas mobilis and NADH oxidase (Nox) from Lactococcus lactis. Acetaldehyde production was systematically improved by knocking out the competing metabolic pathways. Multiple knockout strains were created and a final acetaldehyde titre of 0...
February 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29213327/green-route-to-synthesis-of-valuable-chemical-6-hydroxynicotine-from-nicotine-in-tobacco-wastes-using-genetically-engineered-agrobacterium-tumefaciens-s33
#16
Wenjun Yu, Rongshui Wang, Huili Li, Jiyu Liang, Yuanyuan Wang, Haiyan Huang, Huijun Xie, Shuning Wang
Background: Tobacco is widely planted as an important nonfood economic crop throughout the world, and large amounts of tobacco wastes are generated during the tobacco manufacturing process. Tobacco and its wastes contain high nicotine content. This issue has become a major concern for health and environments due to its toxicity and complex physiological effects. The microbial transformation of nicotine into valuable functionalized pyridine compounds is a promising way to utilize tobacco and its wastes as a potential biomass resource...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29208641/alternative-oxidase-isoforms-are-differentially-activated-by-tricarboxylic-acid-cycle-intermediates
#17
Jennifer Selinski, Andreas Hartmann, Gabriele Deckers-Hebestreit, David A Day, James Whelan, Renate Scheibe
The cyanide-insensitive alternative oxidase (AOX) is a non-proton-pumping ubiquinol oxidase that catalyzes the reduction of oxygen to water and is post-translationally regulated by redox mechanisms and 2-oxo acids. Arabidopsis thaliana possesses five AOX isoforms (AOX1A-D and AOX2). AOX1D expression is increased in aox1a knock-out mutants from A. thaliana (especially after restriction of the cytochrome c pathway), but cannot compensate for the lack of AOX1A, suggesting a difference in regulation of these isoforms...
December 5, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29207340/xanthine-oxidase-inhibitory-activity-of-natural-and-hemisynthetic-flavonoids-from-gardenia-oudiepe-rubiaceae-in%C3%A2-vitro-and-molecular-docking-studies
#18
M D Santi, M Paulino Zunini, B Vera, C Bouzidi, V Dumontet, A Abin-Carriquiry, R Grougnet, M G Ortega
Xanthine oxidase (XO), an enzyme widely distributed among mammalian tissues, is associated with the oxidation of xanthine and hypoxanthine to form uric acid. Reactive oxygen species are also released during this process, leading to oxidative damages and to the pathology called gout. Available treatments mainly based on allopurinol cause serious side effects. Natural products such as flavonoids may represent an alternative. Thus, a series of polymethoxyflavones isolated and hemisynthesized from the bud exudates of Gardenia oudiepe has been evaluated for in vitro XO inhibitory activity...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29204124/alternative-splicing-of-nox4-in-the-failing-human-heart
#19
Zoltán V Varga, Márton Pipicz, Júlia A Baán, Tamás Baranyai, Gábor Koncsos, Przemyslaw Leszek, Mariusz Kuśmierczyk, Fátima Sánchez-Cabo, Pablo García-Pavía, Gábor J Brenner, Zoltán Giricz, Tamás Csont, Luca Mendler, Enrique Lara-Pezzi, Pál Pacher, Péter Ferdinandy
Increased oxidative stress is a major contributor to the development and progression of heart failure, however, our knowledge on the role of the distinct NADPH oxidase (NOX) isoenzymes, especially on NOX4 is controversial. Therefore, we aimed to characterize NOX4 expression in human samples from healthy and failing hearts. Explanted human heart samples (left and right ventricular, and septal regions) were obtained from patients suffering from heart failure of ischemic or dilated origin. Control samples were obtained from donor hearts that were not used for transplantation...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29202033/synthetic-smart-gel-provides-glucose-responsive-insulin-delivery-in-diabetic-mice
#20
Akira Matsumoto, Miyako Tanaka, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-Oka, Hirohito Kuwata, Hironori Yamada, Ibuki Shirakawa, Taiki Miyazawa, Hitoshi Ishii, Kazunori Kataoka, Yoshihiro Ogawa, Yuji Miyahara, Takayoshi Suganami
Although previous studies have attempted to create "electronics-free" insulin delivery systems using glucose oxidase and sugar-binding lectins as a glucose-sensing mechanism, no successful clinical translation has hitherto been made. These protein-based materials are intolerant of long-term use and storage because of their denaturing and/or cytotoxic properties. We provide a solution by designing a protein-free and totally synthetic material-based approach. Capitalizing on the sugar-responsive properties of boronic acid, we have established a synthetic polymer gel-based insulin delivery device confined within a single catheter, which exhibits an artificial pancreas-like function in vivo...
November 2017: Science Advances
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