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https://www.readbyqxmd.com/read/28806285/peritoneal-cavity-lavage-reduces-the-presence-of-mitochondrial-damage-associated-molecular-patterns-in-open-abdomen-patients
#1
Patricia Angellice Martinez-Quinones, Cameron Grant McCarthy, Caleb J Mentzer, Camilla Ferreira Wenceslau, Steven Barry Holsten, R Clinton Webb, Keith O'Malley
BACKGROUND: Mitochondrial damage-associated molecular patterns (mtDAMPs), such as mitochondrial DNA and N-formylated peptides, are endogenous molecules released from tissue after traumatic injury. mtDAMPs are potent activators of the innate immune system. They have similarities with bacteria, which allow mtDAMPs to interact with the same pattern recognition receptors and mediate the development of Systemic Inflammatory Response Syndrome (SIRS). Current recommendations for management of an open abdomen include returning to the operating room every 48 hours for peritoneal cavity lavage until definitive procedure...
August 12, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28777716/research-priorities-in-subspecialty-palliative-care-policy-initiatives
#2
Lynn F Reinke, Diane E Meier
Palliative care demonstrably improves quality of life for the seriously ill in a manner that averts preventable health crises and their associated costs. Because of these outcomes, palliative care is now broadening its reach beyond hospitals, and hospice care for those near death, to patients and their families living in the community with chronic multimorbidities that have uncertain or long expected survival. In this article, we address research needed to enable policies supportive of palliative care access and quality, including changes in regulatory, accreditation, financing, and training approaches in the purview of policy makers...
August 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28767626/a-detailed-comparative-analysis-of-anterior-versus-posterior-approach-to-lenke-5c-curves
#3
Firoz Miyanji, Luigi A Nasto, Tracey Bastrom, Amer F Samdani, Burt Yaszay, David Clements, Suken A Shah, Baron Lonner, Randal R Betz, Harry L Shufflebarger, Peter O Newton
STUDY DESIGN: Prospective cohort study OBJECTIVE.: To prospectively compare radiographic, perioperative and functional outcomes between anterior spinal instrumented fusion (ASIF) and posterior spinal instrumented fusion (PSIF) in Lenke 5C curves. SUMMARY OF BACKGROUND DATA: Historically, ASIF has been the treatment of choice for treatment of thoracolumbar adolescent idiopathic scoliosis (AIS). More recently, PSIF has gained popularity for its ease, versatility and amount of correction achieved...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28765797/radiographic-analysis-of-cervical-and-spinal-alignment-in-multilevel-acdf-with-lordotic-interbody-device
#4
Yoshihiro Katsuura, Alex Lemons, Eileen Lorenz, Rachel Swafford, James Osborn, Garrick Cason
BACKGROUND: Restoration and maintenance of cervical lordosis is an important clinical parameter in spine surgery. The purpose of this study was to determine the extent to which a multilevel anterior cervical discectomy and fusion (ACDF: greater than 3 levels) procedure restores cervical lordosis and the affect of increasing lordosis on sagittal vertical axis. METHODS: We performed a retrospective radiographic analysis of 69 patients who underwent multilevel ACDF by 2 surgeons between 2013 and 2014...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28765796/the-effects-of-topical-vancomycin-on-mesenchymal-stem-cells-more-may-not-be-better
#5
Stacey Chu, Nita Chen, Alexis B C Dang, Alfred C Kuo, Alan B C Dang
BACKGROUND: The use of topical vancomycin is increasingly popular in spine surgery. Large retrospective reviews suggest that topical vancomycin provides a cost-effective decrease in post-operative infection. Currently, there is little that is known about the maximum dose that can be applied locally. When 1 gram of vancomycin is mixed into the bone graft and another 1 gram applied freely in a spine wound, the local concentration of antibiotic ranges from 260-2900 μg/mL in the immediate post-op period and 50-730 μg/mL by the second post-operative day...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28762021/retroverted-glenoid-reconstruction-using-glenoid-plate-in-reverse-shoulder-arthroplasty
#6
R Lanzone, S Carbone, P Albino, J-B Cassio, P Métais
PURPOSE: The objective of this study is to evaluate the clinical and radiological results of reverse shoulder arthroplasty (RSA) with glenoid plating in a consecutive series of patients affected by cuff tear glenohumeral arthropathy with glenoid retroversion >15°. We hypothesized that autologous humeral head graft may be better stabilized between the baseplate and the native glenoid surface with the use of a glenoid plate. METHODS: Twenty consecutive patients affected by cuff tear arthropathy with glenoid retroversion >15° (B2 or C according to Walch classification) were enrolled in this study...
July 31, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28756510/latarjet-procedure-evolution-of-the-bone-block-and-correspondent-clinical-relevance-a-clinical-and-radiological-study
#7
A Vadalà, R M Lanzetti, A De Carli, D Lupariello, M Guzzini, D Desideri, A Ferretti
PURPOSE: The purpose of this study was to correlate the bone block graft position, its dimension, its reabsorption and its integration with clinical outcome in patients operated on for recurrent anterior shoulder instability. METHODS: Twenty-four patients affected by recurrent anterior shoulder dislocation and operated on using the Latarjet procedure were enrolled in this study. At 6 and 24 months, patients were evaluated with the following scales: ROWE, WOSI, Oxford instability score, UCLA, DASH and Constant score...
July 29, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28745656/-effect-of-medicinal-treatment-on-epithelial-wound-healing-after-phacoemulsification
#8
E V Tomilova, M N Nemsitsveridze, I E Panova
AIM: to compare the dynamics of epithelial wound healing under two different post-op treatments in patients after uncomplicated phacoemulsification. MATERIAL AND METHODS: This prospective randomized clinical trial included 40 eyes of 40 patients aged 66.4±8.2 years who underwent uncomplicated phacoemulsification with flexible intraocular lens implantation through a 2.2-mm corneal incision. Patients were randomized to receive either dexamethasone 0.1% and diclofenac 0...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28739402/graft-detachment-and-re-bubbling-rate-in-descemet-membrane-endothelial-keratoplasty
#9
REVIEW
Mohit Parekh, Pia Leon, Alessandro Ruzza, Davide Borroni, Stefano Ferrari, Diego Ponzin, Vito Romano
Descemet Membrane Endothelial Keratoplasty (DMEK) is a selective replacement of dysfunctional endothelium with healthy donor Descemet's membrane and endothelium. Although the donor preparation and surgical methods still remain a challenge, DMEK is gaining popularity in terms of early rehabilitation and visual outcomes. New and improved donor preparation techniques like pre-stripped DMEK tissues are taken up rapidly due to less manipulation that is required in the surgical theatre. Donor graft delivery in the recipient eye has also been improved due to new products like pre-stripped and pre-loaded membranes...
July 21, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28720994/early-migration-of-bone-graft-causing-sigmoid-colon-perforation-after-trans-foraminal-lumbar-interbody-fusion
#10
Bhavuk Garg, Amit Singla, Sahil Batra, Senthil Kumar
BACKGROUND: Tran foraminal lumbar interbody fusion (TLIF) is a well accepted and standard technique of achieving spinal fusion using pedicle screws, cage and bone graft. We are presenting here a case of L4-L5 lumbar canal stenosis managed with TLIF that presented with sigmoid colon perforation due to bone graft migration 4 days after surgery. CASE REPORT: A 35 years old female underwent open TLIF (from right side) with decompression for L4-L5 lumbar canal stenosis...
April 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28712173/surgical-site-infection-in-orthopaedic-implants-and-its-common-bacteria-with-their-sensitivities-to-antibiotics-in-open-reduction-internal-fixation
#11
Muhammad Qaisar Shah, Muhammad Shoib Zardad, Alamzeb Khan, Sajjad Ahmed, Abdus Saboor Awan, Taj Mohammad
BACKGROUND: Surgical site infection in orthopaedic implants is a major problem, causing long hospital stay, cost to the patient and is a burden on health care facilities. It increases rate of nonunion, osteomyelitis, implant failure, sepsis, multiorgan dysfunction and even death. Surgical site infection is defined as pain, erythema, swelling and discharge from wound site. Surgical site infection in orthopaedic implants is more challenging to the treating orthopaedic surgeon as the causative organism is protected by a biofilm over the implant's surface...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28708777/intraoperative-topical-antibiotics-for-infection-prophylaxis-in-pelvic-and-acetabular-surgery
#12
Matthew T Owen, Emily M Keener, Zane B Hyde, Reaves M Crabtree, Parke W Hudson, Russell L Griffin, Jason A Lowe
OBJECTIVES: Determine if topical vancomycin and tobramycin powder reduces the incidence of surgical site infection (SSI) following pelvic ring and acetabulum fracture surgery. DESIGN: Retrospective cohort study SETTING:: University of Alabama at Birmingham, Academic Level I Trauma Center PATIENTS/PARTICIPANTS:: 219 patients (140 meeting inclusion criteria) with pelvic and acetabular fractures who underwent open reduction and internal fixation (ORIF) from March 2012 to November 2013...
June 26, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28708201/the-impact-of-trabecular-metal-on-hip-centre-of-rotation-in-revision-and-complex-primary-hip-arthroplasty-a-radiological-review
#13
Carl O'Brien, Cillian J Keogh, Ailish Hannigan, Stephen Brennan, Cian Kennedy, Rehan Gul, James A Harty
INTRODUCTION: Total hip arthroplasty (THA) is a very successful procedure. Revision THA is becoming increasingly common. Recent developments to improve outcomes include the development of large trabecular metal (TM) acetabular cups and augments. There is a paucity of data on the benefit of these new techniques. METHODS: A single-centre retrospective review consisting of a radiological review of post-op revision THA anteroposterior pelvis. Data collection was performed using the Irish National Orthopaedic Register (INOR) and from a previous project...
July 1, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28706456/reduction-of-long-term-potentiation-at-schaffer-collateral-ca1-synapses-in-the-rat-hippocampus-at-the-acute-stage-of-vestibular-compensation
#14
Gyoung Wan Lee, Jae Hyo Kim, Min Sun Kim
Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes in long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in the CA1 area of the hippocampus during vestibular compensation. The input-output (I/O) relationships of fEPSP amplitudes and LTP induced by theta burst stimulation to Schaffer's collateral commissural fibers were evaluated from the CA1 area of hippocampal slices at 1 day, 1 week, and 1 month after unilateral labyrinthectomy (UL)...
July 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28674908/transperineal-reanastomosis-for-treatment-of-highly-recurrent-anastomotic-strictures-after-radical-retropubic-prostatectomy-extended-follow-up
#15
Victor Maximilian Schuettfort, Roland Dahlem, Luis Kluth, Daniel Pfalzgraf, Clemens Rosenbaum, Tim Ludwig, Margit Fisch, Christoph-Philip Reiss
OBJECTIVES: To re-evaluate safety and efficacy of transperineal reanastomosis (TPRA) as a viable therapeutic option in highly recurrent anastomotic strictures (AS) after radical retropubic prostatectomy (RRP). METHODS: Retrospective analysis by standardized questionnaire inquiring for recurrence of stricture, stress urinary incontinence (SUI), sexual function, satisfaction, and changes in quality of life (QoL) was performed in all patients undergoing TPRA. Validated questionnaires (ICIQ-UI, EQ-5D, and IPSS) were included...
July 3, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28669859/effect-of-the-upper-instrumented-vertebral-level-upper-vs-lower-thoracic-spine-on-gait-ability-after-corrective-surgery-for-adult-spinal-deformity
#16
Mitsuru Yagi, Nobuyuki Fujita, Osahiko Tsuji, Narihiro Nagoshi, Yoshiyuki Yato, Takashi Asazuma, Ken Ishii, Masaya Nakamura, Morio Matsumoto, Kota Watanabe
BACKGROUND CONTEXT: The relationship between gait pattern and the level of upper instrumented vertebra (UIV) in surgically treated patients with adult spinal deformity (ASD) has not been fully documented. PURPOSE: To assess the effect of UIV level for the gait pattern in ASD STUDY DESIGN/SETTING: Prospective case series. PATIENT SAMPLE: Thirty surgically treated consecutive female ASD with lumbosacral fusion (age 67.0±8.4 years; body mass index (BMI) 22...
June 29, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28658091/assessing-estimates-of-patient-safety-derived-from-coded-data
#17
Wazim Narain
The Agency for Healthcare Research and Quality (AHRQ) developed Patient Safety Indicators (PSI) with the goal of detecting and preventing adverse events using administrative data. Use of PSIs to measure safety and quality of care raises questions since they rely heavily on coded data. The goal of this paper is to review literature on AHRQ PSIs, specifically their accuracy in detecting adverse events, and how recent coding changes affect the accuracy of these estimates. The Healthcare Utilization Project (HCUP) National Inpatient Sample (NIS) contains data on more than seven million hospital stays yearly...
July 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/28653181/laparoscopic-sleeve-gastrectomy-for-the-management-of-type-1-diabetes-mellitus
#18
Salman Al Sabah, Eliana Al Haddad, Talal H Muzaffar, Ahmad Almulla
BACKGROUND: The prevalence of obesity is on a continuous rise worldwide, with major studies clearly correlating obesity with the development of chronic metabolic disorders including type 2 diabetes. Bariatric surgery has proven to be beneficial in the management of this condition; however, a limited number of studies exist on its effect on type 1 diabetes. OBJECTIVE: The objective of this study is to evaluate the outcome of laparoscopic sleeve gastrectomy for the management of patients with type 1 diabetes (DM1)...
June 26, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28645673/supra-acetabular-line-is-better-than-supra-iliac-line-for-coronal-balance-referencing-a-study-of-perioperative-whole-spine-x-rays-in-degenerative-lumbar-scoliosis-and-ankylosing-spondylitis-patients
#19
Hwee Weng Dennis Hey, Cheung-Kue Kim, Won-Gyu Lee, Hyung-Suk Juh, Ki-Tack Kim
BACKGROUND CONTEXT: The aim of spinal deformity correction is to restore the spine's functional alignment by balancing it in both the sagittal and coronal planes. Regardless of posture, the ideal coronal profile is straight, and therefore readily assessable. PURPOSE: This study compares two radiological methods to determine which better predicts postoperative standing coronal balance. STUDY DESIGN/SETTING: We conducted a single-centre, radiographic comparative study between 2011 and 2015...
June 20, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28632644/do-former-smokers-exhibit-a-distinct-profile-before-and-after-lumbar-spine-surgery
#20
Ehsan Jazini, Steven D Glassman, Erica F Bisson, Eric A Potts, Leah Y Carreon
STUDY DESIGN: Retrospective longitudinal cohort OBJECTIVES.: To determine if former smokers undergoing lumbar spine surgery have distinct baseline and post-operative Patient Reported Outcomes (PROs) compared to never smokers and current smokers SUMMARY OF BACKGROUND DATA.: Smoking has known deleterious effects on patients undergoing lumbar spine surgery. However, former smokers have not been extensively evaluated. There are few studies regarding the relationship between pack-years or duration of smoking cessation, and subsequent clinical outcome...
June 19, 2017: Spine
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