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https://www.readbyqxmd.com/read/29909551/combined-use-of-leptin-and-mechanical-stress-has-osteogenic-effects-on-ossification-of-the-posterior-longitudinal-ligament
#1
Shuai Chen, Haifeng Zhu, Gangliang Wang, Ziang Xie, Jiying Wang, Jian Chen
PURPOSE: To evaluate the effects of leptin/leptin receptor (LepR) combined with mechanical stress on the development of ossification of the posterior longitudinal ligament (OPLL), which is a disease characterized by ectopic bone formation of the posterior longitudinal ligament (PLL) and can lead to radiculopathy and myelopathy. METHODS: Six human samples of the PLL were analyzed for the expression of leptin and LepR by RT-PCR and western blotting. PLL cells were stimulated with leptin and mechanical stress delivered via a Flexcell tension system, and osteogenic differentiation was evaluated by RT-PCR and western blotting analysis of osteogenic marker expression as well as by alkaline phosphatase (ALP) staining and alizarin red S staining...
June 16, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29909446/graft-considerations-in-posterior-cruciate-ligament-reconstruction
#2
REVIEW
Pierce Johnson, Sean M Mitchell, Simon Görtz
PURPOSE OF REVIEW: To highlight current and established concepts regarding PCL injury and reconstruction. RECENT FINDINGS: Recent biomechanical and clinical studies have brought attention to improved surgical techniques and clinical outcomes of PCL reconstruction. In contrast to anterior cruciate ligament (ACL) injuries, isolated posterior cruciate ligament (PCL) injuries occur much less frequently and have traditionally been treated non-operatively. Even when a PCL injury meets operative indications, outcomes of PCL reconstruction historically do not match the success rates of ACL reconstruction procedures...
June 16, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29909296/anterior-cruciate-ligament-reconstruction-with-the-tape-locking-screw-tls-and-a-short-hamstring-graft-clinical-evaluation-of-61-cases-with-a-minimum-12-months-follow-up
#3
Benoît Orfeuvre, Régis Pailhé, Loïc Sigwalt, Brice Rubens Duval, Gabriel Lateur, Stéphane Plaweski, Dominique Saragaglia
INTRODUCTION: The TLS® technique for anterior cruciate ligament (ACL) reconstruction has the advantages of using only one hamstring tendon (semitendinosus) by preparing a short graft secured with screws and braided strips. The theoretical pitfall of this technique is that the graft length is determined arbitrarily. Thus, if the blind tunnels are not long enough, it will be impossible to tension the graft properly upon fixation. The primary objective of this study was to determine the postoperative side-to-side difference in knee laxity...
June 14, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29908759/cutibacterium-acnes-and-the-shoulder-microbiome
#4
Boyang Qiu, Kait Al, Ana M Pena-Diaz, George S Athwal, Darren Drosdowech, Kenneth J Faber, Jeremy P Burton, David B O'Gorman
BACKGROUND: Advances in DNA sequencing technologies have made it possible to detect microbial genome sequences (microbiomes) within tissues once thought to be sterile. We used this approach to gain insights into the likely sources of Cutibacterium acnes (formerly Propionibacterium acnes) infections within the shoulder. METHODS: Tissue samples were collected from the skin, subcutaneous fat, anterior supraspinatus tendon, middle glenohumeral ligament, and humeral head cartilage of 23 patients (14 male and 9 female patients) during primary arthroplasty surgery...
June 13, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29908655/analysis-of-surface-to-surface-distance-mapping-during-three-dimensional-motion-at-the-ankle-and-subtalar-joints
#5
Sorin Siegler, Tobias Konow, Claudio Belvedere, Andrea Ensini, Rewati Kulkarni, Alberto Leardini
Joint surface interaction and ligament constraints determine the kinematic characteristics of the ankle and subtalar joints. Joint surface interaction is characterized by joint contact mechanics and by relative joint surface position potentially characterized by distance mapping. While ankle contact mechanics was investigated, limited information is available on joint distance mapping and its changes during motion. The purpose of this study was to use image-based distance mapping to quantify this interaction at the ankle and subtalar joints during tri-planar rotations of the ankle complex...
June 7, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29908047/can-surgical-reconstruction-of-vaginal-and-ligamentous-laxity-cure-over-active-bladder-symptoms-in-women-with-pelvic-organ-prolapse
#6
Bernhard Liedl, Klaus Goeschen, Suzette E Sutherland, Jean-Paul Roovers, Alexander Yassouridis
OBJECTIVE: The objective of this interventional study was to examine extent and intensity of the coexistence of overactive bladder (OAB) symptoms in women with pelvic organ prolapse (POP) and to evaluate the likelihood of OAB symptom improvement after surgical POP reconstruction in a period of two years. PATIENTS AND METHODS: The effectiveness of the transvaginal, single-incision Elevate@ technique for anatomical cure of anterior/apical and posterior/apical vaginal prolapse has been previously reported following a prospective, multicenter study...
June 16, 2018: BJU International
https://www.readbyqxmd.com/read/29907859/the-microrna-10a-id3-runx2-axis-modulates-the-development-of-ossification-of-posterior-longitudinal-ligament
#7
Chen Xu, Hao Zhang, Wei Gu, Huiqiao Wu, Yuanyuan Chen, Wenchao Zhou, Baifeng Sun, Xiaolong Shen, Zicheng Zhang, Yue Wang, Yang Liu, Wen Yuan
Ossification of the posterior longitudinal ligament (OPLL) presents as pathological heterotopic ossification of the spinal ligaments. However, its underlying molecular mechanism is still unclear. Our previous findings suggested that altered microRNA regulatory network are critical for the development of OPLL. Here, we set out to unveiling the detailed mechanism of those altered OPLL-specific microRNAs. We screened a set of differentially expressed OPLL-specific microRNAs from the previous sequencing data and showed that microRNA-10a actively modulates the ossification of posterior ligament cells in vitro...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907841/comparison-of-knee-stability-strength-deficits-and-functional-score-in-primary-and-revision-anterior-cruciate-ligament-reconstructed-knees
#8
Do Kyung Kim, Geon Park, Kamarulzaman Bin Haji M S Kadir, Liang-Tseng Kuo, Won Hah Park
Comparing to primary surgery, revision ACL reconstruction is more technically demanding and has a higher failure rate. Theoretically, rehabilitation can improve knee function after ACL reconstruction surgery. This study aimed to compare knee stability, strength, and function between primary and revision ACL reconstructed knees. 40 primary and 40 revision ACL reconstruction surgeries were included between April 2013 and May 2016. Patients with revision surgery had a higher anteroposterior translation comparing those with primary reconstruction (median laxity, 2...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907751/correction-to-long-noncoding-rna-tug1-facilitates-osteogenic-differentiation-of-periodontal-ligament-stem-cells-via-interacting-with-lin28a
#9
Qin He, Shuangyan Yang, Xiuge Gu, Mengying Li, Chunling Wang, Fulan Wei
Since publication of this article, the authors found a mistake in the drawing figure 5e. After careful checking of all original data, the authors discovered that they had submitted the wrong composite figure 5e. The correct Figure 5 is included below.
June 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29907523/effect-of-the-calcaneal-medializing-osteotomy-on-soft-tissues-supporting-the-plantar-arch-a-computational-study
#10
R Larrainzar-Garijo, C Cifuentes de la Portilla, B Gutiérrez-Narvarte, E Díez-Nicolás, J Bayod
Medializing calcaneal osteotomy forms part of the treatment options for adult acquired flat foot. The structural correction that is achieved is widely known. However, the effect of this procedure on the soft tissues that support the plantar arch has been little studied, since it is not possible to quantify experimentally the tension and deformation variations generated. Therefore, the objective of this study was to evaluate the effect of medializing calcaneal osteotomy on the soft tissue that supports the plantar arch, using a computational model of the human foot designed with a clinical approach...
June 12, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29907518/ulnar-collateral-ligament-reconstruction-in-athletes-using-a-cortical-button-suspension-technique
#11
Chad Myeroff, J Logan Brock, G Russell Huffman
BACKGROUND: A variety of techniques currently exist for ulnar collateral ligament (UCL) reconstruction in symptomatic overhead athletes, all with the potential complication of fracture about the humeral or ulnar tunnels. Far cortical button fixation is a reproducible, biomechanically attractive option; however, no clinical series has been published on this technique to date. This study reports the clinical outcomes, with minimum 2-year follow-up, of a dual far cortical button suspension technique for UCL reconstruction in athletes...
June 13, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29906672/displacement-of-teeth-without-and-with-bonded-fixed-orthodontic-retainers-3d-analysis-using-triangular-target-frames-and-optoelectronic-motion-tracking-device
#12
Firas Chakroun, Vera Colombo, Dave Lie Sam Foek, Luigi Maria Gallo, Albert Feilzer, Mutlu Özcan
PURPOSE: The objective of this study was to evaluate the anterior tooth movement without and with bonded fixed orthodontic retainers under incremental loading conditions. MATERIALS AND METHODS: Six extracted mandibular anterior human teeth were embedded in acrylic resin in True Form I Arch type and 3D reconstruction of Digital Volume Tomography (DVT) images (0.4 mm3 voxels) were obtained. The anatomy of each tooth was segmented and digitally reconstructed using 3D visualization software for medical images (AMIRA, FEI SVG)...
June 6, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29906668/elongated-odontoid-process-in-late-holocene-skeletal-remains-from-b6-archaeological-site-mendoza-argentina
#13
J A Suby, P Novellino, G Da Peña, C D Pandiani
The odontoid process of the axis can be affected by congenital or acquired pathologies. While abnormalities such as os odontoideum, agenesis, and fractures are reported in archaeological remains, the abnormality of an elongated length of the odontoid process has not been described in the paleopathological literature. The aim of this paper is to evaluate two individuals with elongated odontoid processes from a skeletal assemblage from the B6 archaeological site (Mendoza, Argentina), and to discuss the possible etiologies of the condition, with particular attention given to the relation to trauma and Crowned Dens Syndrome (CDS), a condition characterized by the ossification of ligaments of the odontoid process of the second cervical vertebra...
June 12, 2018: International Journal of Paleopathology
https://www.readbyqxmd.com/read/29906583/prevalence-incidence-co-morbidity-and-mortality-rates-of-ossification-of-posterior-longitudinal-ligament-opll-in-the-cervical-spine-a-nested-case-control-cohort-study
#14
Bong Ju Moon, Sun Kyu Choi, Dong Ah Shin, Seong Yi, Keung Nyun Kim, Do Heum Yoon, Yoon Ha
OBJECT: To evaluate the prevalence, incidence, morbidity, and mortality rates of cervical ossification of posterior longitudinal ligament (OPLL), using data from a 12-year national cohort of 1,025,340 Korean people. METHODS: A nested case-control cohort study was performed using the insurance claims database, during 2002 to 2013, provided by the National Health Insurance Service. We examined the prevalence and incidence of cervical OPLL. Age/sex-matched controls were randomly extracted, with 10 times the number of OPLL cases...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29906086/biofouling-resistant-platinum-bimetallic-alloys
#15
Ahmed A Farghaly, Rezaul K Khan, Maryanne M Collinson
A new electrosynthetic approach for the fabrication of three-dimensional bicontinuous nanoporous platinum-based (3D-BC-NP-Pt(Au)) electrodes is described. Binary Pt-Ag alloys are first electrodeposited on gold substrates from appropriately formulated plating solutions. Following annealing and dealloying, a new family of nanoporous platinum-based electrodes emerges whose morphology, porosity, and chemical compositions depend on electrodeposition parameters and plating solution composition. Scanning electron microscopy images reveal an interesting and distinctive nanoporous gold-like microstructure with pores and ligaments in the 10-30 nm range arranged in a bicontinuous fashion throughout the thickness of the film...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29905361/treatment-of-osteoarthritis-with-collagen-based-scaffold-a-porcine-animal-model-with-xenograft-mesenchymal-stem-cells
#16
Wo-Ran Tzeng, Shu-Wei Huang, Chih-Hsiang Fang, Lih-Tao Hsu, Chih-Yu Chen, Hsin-Hsin Shen, Jenny Zwei-Chieng Chang, Jui-Sheng Sun, Feng-Huei Lin
OBJECTIVE: With the goal to explore a new approach to treat the early degenerative lesions of hyaline cartilage, we implanted in a porcine OA model a collagen-based scaffold containing chondroprogenitor cells derived from human bone marrow mesenchymal stem cells (hBM-MSCs). EXPERIMENTAL DESIGN: Porcine knee joints were subjected to anterior cruciate ligament (ACL) transection to surgically induce OA. After 4 months, the time necessary for the development of cartilage surface damage, animals were treated either with trephination bone plug wrapped with the chondroprogenic hBM-MSCs-embedded collagen scaffold or microfractures alone...
June 15, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29905051/-new-type-of-sutured-titanium-wire-combined-with-titanium-nail-internal-fixation-for-correction-of-serious-old-medial-canthus-deformity
#17
Ying Zhang, Changhong Zeng, Jun Chen, Bo Guo
Objective: To evaluate the effectiveness of a new type of sutured titanium wire combined with titanium nail internal fixation in correction of serious old medial canthus deformity. Methods: Between March 2012 and June 2015, 18 patients with unilateral serious old medial canthus deformity were treated. There were 14 males and 4 females. The patient's age ranged from 23 to 62 years (mean, 42 years). The causes of deformity included accident injury in 10 cases, boxing injury in 4 cases, sharp device scratching in 3 cases, and animal bite in 1 case...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904933/dna-methylation-profiles-of-immune-response-related-genes-in-apical-periodontitis
#18
C Wichnieski, K Maheshwari, L C Souza, F Nieves, T Tartari, G P Garlet, E Carneiro, A Letra, R M Silva
AIM: To investigate the DNA methylation profiles of immune-response related genes in apical periodontitis (AP) lesions. METHODOLOGY: The methylation profiles on the cytosine-phosphate-guanine (CpG) regions of 22 gene promoters involved in inflammation and autoimmunity were assessed in 60 human AP lesions and 24 healthy periodontal ligaments (controls) using a pathway-specific real-time polymerase chain reaction array (EpiTect® Methyl Signature PCR Array Human Inflammatory Response)...
June 14, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29904897/anterior-cruciate-ligament-repair-past-present-and-future
#19
REVIEW
Piyush Mahapatra, Saman Horriat, Bobby S Anand
BACKGROUND: This article provides a detailed narrative review on the history and current concepts surrounding ligamentous repair techniques in athletic patients. In particular, we will focus on the anterior cruciate ligament (ACL) as a case study in ligament injury and ligamentous repair techniques. PubMed (MEDLINE), EMBASE and Cochrane Library databases for papers relating to primary anterior cruciate ligament reconstruction were searched by all participating authors. All relevant historical papers were included for analysis...
June 15, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29904155/moringin-induces-neural-differentiation-in-the-stem-cell-of-the-human-periodontal-ligament
#20
Letizia Romeo, Francesca Diomede, Agnese Gugliandolo, Domenico Scionti, Fabrizio Lo Giudice, Veronica Lanza Cariccio, Renato Iori, Placido Bramanti, Oriana Trubiani, Emanuela Mazzon
The therapeutic strategies for neurodegenerative diseases still represent a vast research field because of the lack of targeted, effective and resolutive treatment for neurodegenerative diseases. The use of stem cell-based therapy is an alternative approach that could lead to the replacement of damaged neuronal tissue. For this purpose, adult mesenchymal stem cells (MSC), including periodontal ligament stem cells (PDLSCs), could be very useful for their differentiation capacity, easy isolation and the ability to perform an autologous implant...
June 14, 2018: Scientific Reports
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