keyword
https://read.qxmd.com/read/38110600/preoperative-sleep-disordered-breathing-and-craniofacial-abnormalities-are-risk-factors-for-postoperative-sleep-disordered-breathing-in-patients-undergoing-skin-flap-oropharyngeal-reconstruction-surgery-for-oral-cavity-cancer-a-prospective-case-control-study
#21
JOURNAL ARTICLE
Fumihiro Yoshikawa, Natsuko Nozaki-Taguchi, Ayumi Yamamoto, Nozomi Tanaka, Aika Tanzawa, Katsuhiro Uzawa, Shiroh Isono
PURPOSE: After oropharyngeal reconstruction surgery, excessive flap volume within the oral cavity may increase the risk of pharyngeal obstruction during sleep. This prospective observational study aimed to test a hypothesis that the skin-flap oropharyngeal reconstructive surgery increases nocturnal apnea-hypopnea index (nAHI, primary variable) after surgery. METHODS: Adult patients undergoing oropharyngeal reconstruction surgery participated in this study. The hypothesis was tested by comparing the results of portable type 4 sleep study and craniofacial assessments with lateral head and neck computed tomography scout image before and after surgery...
December 18, 2023: Sleep & Breathing
https://read.qxmd.com/read/38108881/sleep-and-quality-of-life-in-kidney-transplant-recipients-with-and-without-non-melanoma-skin-cancer-a-comparative-study
#22
JOURNAL ARTICLE
Ellen M S Xerfan, Gabriela M Leandro, Gabriel N Pires, Monica L Andersen, Sergio Tufik, Anamaria S Facina, Jane Tomimori
Non-melanoma skin cancer (NMSC) is prevalent in kidney transplant recipients (KTR), related to the immunosuppressive effects of anti-rejection therapy. Sleep disturbances can alter the immune system and enhance oxidative stress, which may increase the risk of carcinogenesis. This study aimed to analyze the quality of life and sleep in KTR with and without NMSC. Participants answered a set of questionnaires, the WHOQOL-bref, the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), the Berlin Questionnaire and self-reported chronotype...
December 18, 2023: Archives of Dermatological Research
https://read.qxmd.com/read/38095241/retrospective-review-of-acute-post-tracheostomy-complications-and-contributing-risk-factors
#23
JOURNAL ARTICLE
Ericka L Erickson, Juhi Katta, Shuai Sun, Lingpeng Shan, Stanley Lemeshow, Minka L Schofield
OBJECTIVE: Tracheostomy is performed for various indications ranging from prolonged ventilation to airway obstruction. Many factors may play a role in the incidence of complications in the immediate post-operative period including patient-related factors. Chronic obstructive pulmonary disease and asthma are some of the most common pulmonary pathologies in the United States. The relationship between obstructive pulmonary diseases and acute post-tracheostomy complications has been incompletely studied...
March 2024: Clinical Otolaryngology
https://read.qxmd.com/read/38084109/a-cross-sectional-survey-on-the-effects-of-ambient-temperature-and-humidity-on-health-outcomes-in-individuals-with-chronic-respiratory-disease
#24
JOURNAL ARTICLE
Samantha Mekhuri, Shirley Quach, Caroline Barakat, Winnie Sun, Mika L Nonoyama
RATIONALE: Extremes of temperature and humidity are associated with adverse respiratory symptoms, reduced lung function, and increased exacerbations among individuals living with chronic obstructive pulmonary disease (COPD). OBJECTIVES: To describe the reported effects of temperature and humidity extremes on the health outcomes, health status and physical activity (PA) in individuals living with COPD. METHODS: A cross-sectional self-reported survey collected the effects on health status (COPD Assessment Test [CAT]), PA, and health outcomes in 1) moderate/ideal (14 to 21°C, 30 to 50% relative humidity [RH]), 2) hot and humid (≥ 25°C, > 50% RH) and 3) cold and dry (≤ 5°C, < 30% RH) weather conditions...
2023: Canadian Journal of Respiratory Therapy: CJRT
https://read.qxmd.com/read/38076538/cellular-senescence-in-brain-aging-and-cognitive-decline
#25
REVIEW
Areez Shafqat, Saifullah Khan, Mohamed H Omer, Mahnoor Niaz, Ibrahem Albalkhi, Khaled AlKattan, Ahmed Yaqinuddin, Tamara Tchkonia, James L Kirkland, Shahrukh K Hashmi
Cellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases. Clinical trials are currently underway to evaluate the effectiveness of senotherapies for these diseases. However, the impact of senescence on brain aging and cognitive decline in the absence of neurodegeneration remains uncertain. Moreover, patient populations like cancer survivors, traumatic brain injury survivors, obese individuals, obstructive sleep apnea patients, and chronic kidney disease patients can suffer age-related brain changes like cognitive decline prematurely, suggesting that they may suffer accelerated senescence in the brain...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38067152/hypoxia-induces-alterations-in-the-circadian-rhythm-in-patients-with-chronic-respiratory-diseases
#26
REVIEW
Manuel Castillejos-López, Yair Romero, Angelica Varela-Ordoñez, Edgar Flores-Soto, Bianca S Romero-Martinez, Rafael Velázquez-Cruz, Joel Armando Vázquez-Pérez, Víctor Ruiz, Juan C Gomez-Verjan, Nadia A Rivero-Segura, Ángel Camarena, Ana Karen Torres-Soria, Georgina Gonzalez-Avila, Bettina Sommer, Héctor Solís-Chagoyán, Ruth Jaimez, Luz María Torres-Espíndola, Arnoldo Aquino-Gálvez
The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present in the body's tissues and helps regulate various processes such as sleeping, eating, and others. Interestingly, animal models have provided enough evidence to assume that the alteration in the circadian system leads to the appearance of numerous diseases. Alterations in breathing patterns in lung diseases can modify oxygenation and the circadian cycles; however, the response mechanisms to hypoxia and their relationship with the clock genes are not fully understood...
November 29, 2023: Cells
https://read.qxmd.com/read/38054465/a-cross-sectional-analysis-of-the-association-between-sleep-disorders-and-cancer-using-data-from-the-national-health-and-nutrition-examination-survey-nhanes-2005-2014
#27
JOURNAL ARTICLE
Allan Saj Porcacchia, Gabriel Natan Pires, Monica Levy Andersen, Sergio Tufik
STUDY OBJECTIVES: Cancer is one of the main causes of death in the world, while sleep disorders are a serious public health problem, especially in large cities, insomnia and obstructive sleep apnea (OSA) being the most common. In the last decade, studies have pointed to a possible association between sleep disorders and cancer. The aim of this study is to evaluate whether there is any association between sleep disorders and cancer diagnosis. METHODS: Five National Health and Nutrition Examination Surveys (NHANES) (2005-2014) from the United States were combined in order to obtain the sample...
December 6, 2023: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/38024815/common-clinical-laboratory-features-among-women-with-polycystic-ovary-syndrome-and-metabolic-syndrome
#28
JOURNAL ARTICLE
Volodymyr Artyomenko, Valentyna Velychko, Daria Lahoda, Halyna Danylchuk
Women with polycystic ovary syndrome (PCOS) have a high prevalence of metabolic syndrome (MS), with rates up to 33%. This is associated with long-term consequences such as cardiovascular diseases, type 2 diabetes mellitus (T2DM), cancer, sleep apnea, and psychological issues. The prevalence of MS worldwide is often associated with obesity and T2DM, yet regional variations are reported. In this study, 122 women consulting general practice and family medicine physicians were evaluated, revealing a BMI exceeding 30 kg/m2 ...
August 2023: Journal of Medicine and Life
https://read.qxmd.com/read/38010093/obstructive-sleep-apnea-promotes-the-progression-of-lung-cancer-by-modulating-cancer-cell-invasion-and-cancer-associated-fibroblast-activation-via-tgf%C3%AE-signaling
#29
JOURNAL ARTICLE
Zhilei Cui, Zhengshang Ruan, Meigui Li, Rongrong Ren, Yizong Ma, Junxiang Zeng, Jinyuan Sun, Wenjing Ye, Weiguo Xu, Xuejun Guo, Dengfei Xu, Linlin Zhang
OBJECTIVE: Obstructive sleep apnea (OSA) is associated with severity of pneumonia; however, the mechanism by which OSA promotes lung cancer progression is unclear. METHODS: Twenty-five lung cancer patients were recruited to investigate the relationship between OSA and cancer-associated fibroblast (CAFs) activation. Lung cancer cells (A549) and WI38 fibroblast cells were used to explore the hypoxia-induced TGFβ expression using qPCR, Western blot, and ELISA...
December 2023: Redox Report: Communications in Free Radical Research
https://read.qxmd.com/read/38004008/comorbidities-and-laryngeal-cancer-in-patients-with-obstructive-sleep-apnea-a-review
#30
REVIEW
Beata Kiss, Cristian Mircea Neagos, Gabriela Jimborean, Hédi Katalin Sárközi, Mioara Szathmary, Adriana Neagos
Introductions : The global prevalence of obstructive sleep apnea shows that this disease appears in 1 billion people, with the prevalence exceeding 50% in some countries. Treatment is necessary to minimize negative health impacts. Obstructive sleep apnea (OSA) is defined as a cause of daytime sleepiness, as well as a clinical manifestation of sleep-disordered breathing. In the literature, there are numerous controversial studies regarding the etiology of this condition, but it is universally accepted that reduced activity in the upper airway muscles plays a significant role in its onset...
November 6, 2023: Medicina
https://read.qxmd.com/read/37997620/unilateral-tonsillar-enlargement-as-initial-presentation-of-bilateral-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#31
JOURNAL ARTICLE
Allie M Ottinger, Roshansa Singh, Dong Chen, Kourosh Parham
Unilateral tonsillar enlargement is a common indication for tonsillectomy, but there are varying rates of malignancy among tonsils removed for asymmetry and a lack of clear guidelines for management within the literature. Lymphoma of the palatine tonsils is among the concerns leading to tonsillectomy, but chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) of the tonsil is rare. We report a case of primary CLL/SLL of the palatine tonsil in a 51-year-old gentleman who presented with tonsillar asymmetry and obstructive sleep apnea (OSA) but lacked signs and symptoms suspicious for malignancy, including lymphadenopathy and "B-symptoms...
November 24, 2023: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/37990480/does-obstructive-sleep-apnea-increase-the-risk-of-cancer-and-cancer-mortality-in-combined-community-based-cohorts
#32
JOURNAL ARTICLE
Jenny Theorell-Haglöw, Xingwu Zhou, Gary Wittert, Robert Adams, Sarah Appleton, Amy Reynolds, Mirjam Ljunggren, Nathaniel Marshall
Obstructive sleep apnea (OSA) has been linked to cancer in several clinical and community-based cohorts. The effect in community-based studies free of clinical referral bias needs to be replicated. In this observational prospective cohort study, we pooled data from three community-based prospective cohorts (Uppsala Sleep and Health in Men cohort [UMEN]; Sleep and health in women [SHE]; Men Androgen Inflammation Lifestyle Environment and Stress Cohort [MAILES]; nTotal  = 1467). All cohorts had objective data on obstructive sleep apnea and registry linkage data on cancer and cancer mortality...
November 21, 2023: Journal of Sleep Research
https://read.qxmd.com/read/37987324/major-adverse-cardiac-and-cerebrovascular-events-in-geriatric-patients-with-obstructive-sleep-apnea-an-inpatient-sample-analysis
#33
JOURNAL ARTICLE
Rupak Desai, Sai Priyanka Mellacheruvu, Sai Anusha Akella, Adil Sarvar Mohammed, Pakhal Saketha, Abdul Aziz Mohammed, Mushfequa Hussain, Aamani Bavanasi, Jyotsna Gummadi, Praveena Sunkara
BACKGROUND: Obstructive sleep apnea (OSA) is associated with an increased risk of major cardiac and cerebrovascular events (MACCE). However, data on the burden and predictors of MACCE in geriatric patients with OSA (G-OSA) remain limited. METHODS: Using the National Inpatient Sample from 2018, we identified G-OSA admissions (age ≥ 65 years) and divided them into non-MACCE vs. MACCE (all-cause mortality, stroke, acute myocardial infarction, and cardiac arrest)...
October 30, 2023: Medical Sciences: Open Access Journal
https://read.qxmd.com/read/37904164/serum-anti-pck1-antibody-levels-are-a-prognostic-factor-for-patients-with-diabetes-mellitus
#34
JOURNAL ARTICLE
Toshiki Namiki, Minoru Takemoto, Aiko Hayashi, Hiroki Yamagata, Takahiro Ishikawa, Koutaro Yokote, Shu-Yang Li, Masaaki Kubota, Bo-Shi Zhang, Yoichi Yoshida, Tomoo Matsutani, Seiichiro Mine, Toshio Machida, Yoshio Kobayashi, Jiro Terada, Akira Naito, Koichiro Tatsumi, Hirotaka Takizawa, Rika Nakamura, Hideyuki Kuroda, Yasuo Iwadate, Takaki Hiwasa
BACKGROUND: Autoantibodies develop in autoimmune diseases, cancer, diabetes mellitus (DM), and atherosclerosis-related diseases. However, autoantibody biomarkers have not been successfully examined for diagnosis and therapy. METHODS: Serological identification of antigens through recombinant cDNA expression cloning (SEREX) was used for primary screening of antigens. The cDNA product was expressed in bacteria and purified. Amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA) was used to evaluate antibody levels in serum samples...
October 30, 2023: BMC Endocrine Disorders
https://read.qxmd.com/read/37888091/relationship-of-medication-intake-and-systemic-conditions-with-periodontitis-a-retrospective-study
#35
JOURNAL ARTICLE
Georgios S Chatzopoulos, Ziou Jiang, Nicholas Marka, Larry F Wolff
OBJECTIVES: To examine the potential relationship of medication intake and systemic conditions with periodontitis. METHODS AND MATERIALS: A total of 1985 patient records with a diagnosis of periodontal health and stage III and IV periodontitis were included in the analysis. Demographic characteristics, the number of missing teeth, patient-reported medical conditions and medication intake as well as smoking habits were recorded. Regression models were performed to explore the outcomes...
October 10, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37868505/the-promising-frontier-of-cardiometabolic-syndrome-a-new-paradigm-in-cardiology
#36
REVIEW
Ahmad R Khan, Abdelaziz H Salama, Zoha Aleem, Hussein Alfakeer, Lujain Alnemr, Amena Maheen M Shareef
Cardiometabolic syndrome (CMS) is a complex interplay of metabolic dysregulation, cardiovascular disease (CVD), and diabetes risk factors. It encompasses obesity, insulin resistance, dyslipidemia, hyperuricemia, and hypertension, with obesity triggering metabolic disturbances. The global prevalence of CMS, driven by rising obesity rates and sedentary lifestyles, varies across regions. Underlying CMS mechanisms intertwine genetics, sedentary behaviors, poor diets, and hormonal imbalances. Genetic predisposition interacts with environmental factors, while sedentary lifestyles and poor diets amplify obesity and insulin resistance...
September 2023: Curēus
https://read.qxmd.com/read/37868473/the-effectiveness-of-nutritional-strategies-in-the-treatment-and-management-of-obesity-a-systematic-review
#37
REVIEW
Oluwakemi L Adeola, Ginikachukwu M Agudosi, Ngozi T Akueme, Okelue E Okobi, Falilatu B Akinyemi, Uchechi O Ononiwu, Henrietta S Akunne, Micheal K Akinboro, Omosefe E Ogbeifun, Matayebi Okeaya-Inneh
Obesity, a condition primarily resulting from positive energy balance, has become a significant global health concern. Numerous studies have demonstrated that obesity is a major risk factor for various illnesses, including different types of cancer, coronary heart disease, sleep apnea, CV stroke, type II diabetes mellitus, etc. To effectively address this issue, prevention and treatment approaches to manage body weight are crucial. There are several evidence-based approaches available for the treatment and management of obesity, taking into account factors such as body mass index classification, individual weight history, and existing comorbidities...
September 2023: Curēus
https://read.qxmd.com/read/37854605/psgl-1-a-novel-immune-checkpoint-driving-t-cell-dysfunction-in-obstructive-sleep-apnea
#38
JOURNAL ARTICLE
Elena Díaz-García, Aldara García-Sánchez, Enrique Alfaro, Cristina López-Fernández, Eva Mañas, Irene Cano-Pumarega, Eduardo López-Collazo, Francisco García-Río, Carolina Cubillos-Zapata
INTRODUCTION: Although higher incidence of cancer represents a major burden for obstructive sleep apnea (OSA) patients, the molecular pathways driving this association are not completely understood. Recently, the adhesion receptor P-selectin glycoprotein-1 (PSGL 1) has been identified as a novel immune checkpoint, which are recognized major hallmarks in several types of cancer and have revolutionized cancer therapy. METHODS: The expression of PSGL-1 and its ligands VISTA and SIGLEC-5 was assessed in the leucocytes of OSA patients and control subjects exploring the role of intermittent hypoxia (IH) using in vitro models...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37835421/the-effects-of-different-types-of-sleep-disorder-on-colorectal-cancer-a-nationwide-population-based-cohort-study
#39
JOURNAL ARTICLE
Po-Lin Chiang, Wen-Rui Hao, Hong-Jye Hong, Chun-Chao Chen, Chun-Chih Chiu, Yu-Ann Fang, Tsung-Lin Yang, Yu-Hsin Lai, Ming-Yao Chen, Min-Huei Hsu, Kuan-Rau Chiou, Kuan-Jie Lin, Tsung-Yeh Yang, Hsin Hsiu, Ju-Chi Liu
The impact of sleep disorders (SDs), particularly sleep apnea (SA), on the development of colorectal cancer (CRC) has been the subject of significant research. However, the potential contribution of other SDs to the incidence of CRC remains unexplored. The objective of this study was to examine the effects of SDs on the risk of developing CRC. This study assessed CRC risk among individuals diagnosed with SDs compared with age- and sex-matched unaffected individuals. A longitudinal, nationwide, population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database (NHIRD) encompassing 177,707 individuals diagnosed with SDs and 177,707 matched controls...
September 26, 2023: Cancers
https://read.qxmd.com/read/37834257/intermittent-hypoxia-promotes-tam-induced-glycolysis-in-laryngeal-cancer-cells-via-regulation-of-hk1-expression-through-activation-of-zbtb10
#40
JOURNAL ARTICLE
Minlan Yang, Weisong Cai, Zehua Lin, Aikebaier Tuohuti, Xiong Chen
Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), may increase the risk of cancer development and a poor cancer prognosis. TAMs of the M2 phenotype, together with the intermittent hypoxic environment within the tumor, drive tumor aggressiveness. However, the mechanism of TAMs in IH remains unclear. In our study, IH induced the recruitment of macrophages, and IH-induced M2-like TAMs promoted glycolysis in laryngeal cancer cells through hexokinase 1. The hexokinase inhibitor 2-deoxy-D-glucose and HK1 shRNA were applied to verify this finding, confirming that M2-like TAMs enhanced glycolysis in laryngeal cancer cells through HK1 under intermittent hypoxic conditions...
September 30, 2023: International Journal of Molecular Sciences
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