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Sleep apnea and cancer

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https://www.readbyqxmd.com/read/29589988/laparoscopic-sleeve-gastrectomy-for-morbid-obesity-at-a-veterans-affairs-medical-center
#1
Matthew Skancke, Clint Schoolfield, Robert Grossman, Jennifer C Kerns, Nicole Abel, Fredrick Brody
BACKGROUND: Class III obesity is a global health emergency associated with an increase in the incidence of many other diseases such as type 2 diabetes mellitus, hypertension, hyperlipidemia, cancer, obstructive sleep apnea, nonalcoholic fatty liver disease, osteoarthritis, infertility, and mental health disorders. Minimal work has been published regarding the efficacy of laparoscopic sleeve gastrectomy (LSG) in the veteran population to surgically manage morbid obesity. DESIGN: Retrospective analysis of LSG performed at a Veterans Affairs Medical Center (VAMC) between 2010 and 2017...
March 28, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29562364/testosterone-therapy-in-men-with-hypogonadism-an-endocrine-society-clinical-practice-guideline
#2
Shalender Bhasin, Juan P Brito, Glenn R Cunningham, Frances J Hayes, Howard N Hodis, Alvin M Matsumoto, Peter J Snyder, Ronald S Swerdloff, Frederick C Wu, Maria A Yialamas
Objective: To update the "Testosterone Therapy in Men With Androgen Deficiency Syndromes" guideline published in 2010. Participants: The participants include an Endocrine Society-appointed task force of 10 medical content experts and a clinical practice guideline methodologist. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
March 17, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29549733/combining-deep-residual-neural-network-features-with-supervised-machine-learning-algorithms-to-classify-diverse-food-image-datasets
#3
Patrick McAllister, Huiru Zheng, Raymond Bond, Anne Moorhead
Obesity is increasing worldwide and can cause many chronic conditions such as type-2 diabetes, heart disease, sleep apnea, and some cancers. Monitoring dietary intake through food logging is a key method to maintain a healthy lifestyle to prevent and manage obesity. Computer vision methods have been applied to food logging to automate image classification for monitoring dietary intake. In this work we applied pretrained ResNet-152 and GoogleNet convolutional neural networks (CNNs), initially trained using ImageNet Large Scale Visual Recognition Challenge (ILSVRC) dataset with MatConvNet package, to extract features from food image datasets; Food 5K, Food-11, RawFooT-DB, and Food-101...
February 17, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29548630/sleep-apnea-morbidity-a-consequence-of-microbial-immune-cross-talk
#4
REVIEW
Nuria Farré, Ramon Farré, David Gozal
Obstructive Sleep Apnea (OSA) has emerged as a highly prevalent public health problem that imposes important mid-term and long-term consequences, namely cardiovascular, metabolic, cognitive and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction during sleep. Recurrent collapse of the upper airway develops with sleep onset, and is associated with both intermittent hypoxemia and sleep fragmentation. The microbiome is a vast and complex polymicrobial ecosystem that coexists with the human organism, and has been identified as playing significant roles in the development of host immunological phenotypes...
March 13, 2018: Chest
https://www.readbyqxmd.com/read/29523293/perceived-fatigue-and-energy-are-independent-unipolar-states-supporting-evidence
#5
Bryan D Loy, Michelle H Cameron, Patrick J O'Connor
Persistent fatigue is a common problem (∼20-45% of U.S. population), with higher prevalence and severity in people with medical conditions such as cancer, depression, fibromyalgia, heart failure, sleep apnea and multiple sclerosis. There are few FDA-approved treatments for fatigue and great disagreement on how to measure fatigue, with over 250 instruments used in research. Many instruments define fatigue as "a lack of energy", thus viewing energy and fatigue states as opposites on a single bipolar continuum...
April 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29520134/obstructive-sleep-apnea-copd-the-overlap-syndrome-and-mortality-results-from-the-2005-2008-national-health-and-nutrition-examination-survey
#6
Wei Du, Jun Liu, Jianlong Zhou, Dan Ye, Yan OuYang, Qingnan Deng
Objective: The aim of this study was to investigate the role of obstructive sleep apnea (OSA) on all-cause mortality in patients with COPD. Methods: Data for this cross-sectional study were obtained from the National Health and Nutrition Examination Survey (NHANES) data (year 2005-2008). Eligible subjects were ≥20 years who had no COPD or OSA (n=9,237), had only OSA (n=366), had only COPD (n=695), and had OSA/COPD overlap syndrome (n=90). Univariate and multivariate analyses were used to evaluate factors associated with overall mortality...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29518206/the-science-of-obesity-management-an-endocrine-society-scientific-statement
#7
George A Bray, William E Heisel, Ashkan Afshin, Michael D Jensen, William H Dietz, Michael Long, Robert F Kushner, Stephen R Daniels, Thomas A Wadden, Adam G Tsai, Frank B Hu, John M Jakicic, Donna H Ryan, Bruce M Wolfe, Thomas H Inge
The prevalence of obesity, measured by body mass index, has risen to unacceptable levels in both men and women in the United States and worldwide with resultant hazardous health implications. Genetic, environmental, and behavioral factors influence the development of obesity, and both the general public and health professionals stigmatize those who suffer from the disease. Obesity is associated with and contributes to a shortened life span, type 2 diabetes mellitus, cardiovascular disease, some cancers, kidney disease, obstructive sleep apnea, gout, osteoarthritis, and hepatobiliary disease, among others...
March 6, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29477718/prevalence-and-characteristics-of-urinary-incontinence-in-a-treatment-seeking-male-prospective-cohort-results-from-the-lurn-study
#8
Brian T Helfand, Abigail R Smith, H Henry Lai, Claire C Yang, John L Gore, Brad A Erickson, Karl J Kreder, Anne P Cameron, Kevin P Weinfurt, James W Griffith, Aaron Lentz, Pooja Talaty, Victor P Andreev, Ziya Kirkali
PURPOSE: Male urinary incontinence (UI) is thought to be infrequent. We sought to describe the prevalence of UI in a male treatment-seeking cohort enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). MATERIALS AND METHODS: The inclusion/exclusion criteria, including men with prostate cancer or a neurogenic bladder, have been previously reported. LURN participants prospectively completed questionnaires regarding lower urinary tract symptoms (LUTS) and other clinical variables...
February 22, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29433520/intermittent-hypoxia-promotes-melanoma-lung-metastasis-via-oxidative-stress-and-inflammation-responses-in-a-mouse-model-of-obstructive-sleep-apnea
#9
Lian Li, Fangyuan Ren, Chao Qi, Leiqian Xu, Yinshan Fang, Maoli Liang, Jing Feng, Baoyuan Chen, Wen Ning, Jie Cao
BACKGROUND: Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor metastasis is accelerated by OSA-like IH remain to be elucidated. METHODS: C57BL/6 J male mice were subjected to intravenous injection of B16F10 melanoma cells before receiving IH treatment...
February 12, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29390281/comparison-of-safety-and-effectiveness-between-laparoscopic-mini-gastric-bypass-and-laparoscopic-sleeve-gastrectomy-a-meta-analysis-and-systematic-review
#10
REVIEW
Fu-Gang Wang, Zhao-Peng Yu, Wen-Mao Yan, Ming Yan, Mao-Min Song
BACKGROUND: The laparoscopic mini-gastric bypass is a newly emerged surgical procedure in recent years. Owe to safe and simple process and effective outcomes, laparoscopic mini-gastric bypass has quickly become one of the most popular procedures in some countries. The safety and effectiveness of laparoscopic mini-gastric bypass versus laparoscopic sleeve gastrectomy remain unclear. METHODS: A systematic literature search was performed in PubMed, Embase, Cochrane library from inception to May 20, 2017...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29317057/the-complex-associations-between-obstructive-sleep-apnea-and-auto-immune-disorders-a-review
#11
Mayand Vakil, Steven Park, Anna Broder
Obstructive sleep apnea is known to be associated with diseases such as hypertension, metabolic disorder, and cancer. A more controversial and less understood association is that of sleep apneas and the development and worsening of autoimmune and rheumatologic disorders. Through the main pathways of intermittent hypoxia and sleep deprivation, we hypothesize that obstructive sleep apnea creates a chronic inflammatory state that worsens or incites autoimmune disorders. This thorough review of the available literature highlights our current understanding of the relationship between these disease processes in order to demonstrate the importance of diagnosis and appropriate management of sleep disorders in patients suffering from rheumatologic diseases...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29285942/-non-alcoholic-fatty-liver-disease-as-a-component-of-the-metabolic-syndrome-and-its-causal-correlations-with-other-extrahepatic-diseases
#12
REVIEW
Tamás Halmos, Ilona Suba
Non-alcoholic fatty liver disease is the most common non-infectious chronic liver-disease in our age, and is a spectrum of all the diseases associated with increased fat accumulation in the hepatocytes. Its development is promoted by sedentary life-style, over-feeding, and certain genetic predisposition. Prevalence in the adult population, even in Hungary is ~30%. In a part of cases, this disease may pass into non-alcoholic steatohepatitis, later into fibrosis, rarely into primary hepatocellular cancer. Fatty liver is closely and bidirectionally related to the metabolic syndrome and type 2 diabetes, and nowadays there is a general consensus that fatty liver is the hepatic manifestation of the metabolic sycndrome...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29283409/omentin-a-novel-adipokine-in-respiratory-diseases
#13
REVIEW
Yan Zhou, Bo Zhang, Caixia Hao, Xiaoting Huang, Xiaohong Li, Yanhong Huang, Ziqiang Luo
Adipokines, secreted by the adipose tissue, are extensively involved in the regulation and maintenance of various physiological and pathological processes, including insulin sensitivity, energy expenditure, glucose and lipid metabolism, inflammatory activity, neuroendocrine activity, immunity, cancer, homeostasis, angiogenesis, cardiovascular function, breeding and bone metabolism, and all functions of the endocrine-reproductive system axis. Omentin is a recently identified adipokine, which has become a research hotspot due to its pleiotropic effects on various diseases...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29247296/decrease-of-perforin-positive-cd3-%C3%AE-%C3%AE-t-cells-in-patients-with-obstructive-sleep-disordered-breathing
#14
Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luis Ferreira Moita
INTRODUCTION: Sleep related breathing disorders (SRBD) cause sleep fragmentation, intermittent hypoxia or a combination of both leading to homeostasis perturbations, including in the immune system. We investigated whether SRBD patients with or without intermittent hypoxia show substantial differences in perforin and granzyme-B positive peripheral blood lymphocytes. METHODS: A total of 87 subjects were included and distributed as follows: 24 controls (C), 19 patients with respiratory effort related arousals due to increased upper airway resistance (UAR) without hypoxic events, 24 obese patients with obstructive sleep apnea (OSA) (oOSA), and 20 without obesity (noOSA)...
March 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29241201/cot-death-history-of-an-iatrogenic-disaster
#15
Michael Obladen
Since antiquity, cot death has been explained as accidental suffocation, overlaying, or smothering. Parents were blamed for neglect or drunkenness. A cage called arcuccio was invented around 1570 to protect the sleeping infant. Up to the 19th century, accidents were registered as natural causes of death. From 1830, accidental suffocation became unacceptable for physicians and legislators, and "natural" explanations for the catastrophe were sought, with parents being consoled rather than blamed. Two assumed causes had serious consequences: thymus hyperplasia was irradiated, causing thyroid cancer, and the concept of central apnea was widely accepted, which led to home monitors and distracted from epidemiological evidence...
2018: Neonatology
https://www.readbyqxmd.com/read/29208477/impact-of-opioid-therapy-on-sleep-and-respiratory-patterns-in-adults-with-advanced-cancer-receiving-palliative-care
#16
Phillip Good, Ross Pinkerton, Simon Bowler, Justin Craig, Janet Hardy
CONTEXT: In advanced cancer, abnormal sleep patterns may contribute to poor quality of life, but the impact of opioid-related sleep disorders has not been explored in detail in these patients. OBJECTIVE: To document sleep and respiratory patterns in patients with cancer, receiving a range of opioids, determine factors that contribute to severity of central or obstructive apnea, and to what extent these contribute to sleep disturbance. METHODS: Adults with advanced cancer admitted to a palliative care service underwent a sleep analysis by an unattended polysomnography...
March 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29198302/obstructive-sleep-apnea-in-gestational-diabetes-a-pilot-study-of-the-role-of-the-hypothalamic-pituitary-adrenal-axis
#17
Margaret H Bublitz, Joao Filipe Monteiro, Andrew Caraganis, Susan Martin, Jeffrey Parker, Lucia Larson, Margaret A Miller, Ghada Bourjeily
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) in pregnancy is associated with gestational diabetes mellitus (GDM). This propensity toward heightened insulin resistance in OSA patients has not been well characterized and may be related to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. The aim of this study was to (1) assess the prevalence of OSA in pregnant women with GDM, (2) evaluate whether HPA axis dysregulation relates to OSA, and (3) investigate the relation between insulin resistance and OSA...
January 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29156933/prevention-of-obesity-from-perinatal-stage
#18
Rosa Mª Martínez García, Ana Isabel Jiménez Ortega, Heldry González Torres, Rosa María Ortega
Obesity is one of the major health problems and a determining factor in the prevalence of diseases such as metabolic syndrome, asthma, sleep apnea, infertility and various types of cancer. Its origin is multifactorial, involving genetic, socioeconomic and environmental factors. These last ones contribute mostly to explain the current epidemic growth of this disease. The sedentary lifestyle, inadequate diet, lack of sleep, alterations in intestinal microbiota and stress are factors related to its development...
October 15, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29132198/clinical-features-of-snoring-patients-during-sedative-endoscopy
#19
Jung Wha Chung, Nayoung Kim, Jee Hye Wee, Jaebong Lee, Jongchan Lee, Soohoon Kwon, Young-Jae Hwang, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Jin-Wook Kim
Background/Aims: Snoring is the sound of turbulence and vibration of the upper respiratory tissues and has been identified as a risk factor of obstructive sleep apnea (OSA) and cardiovascular disease. The aim of this study was to identify associated clinical factors in snoring patients undergoing sedative endoscopy. Methods: A total of 49 patients who snored during standard sedative endoscopy and 127 controls were prospectively enrolled from June 2015 to June 2016...
November 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29115823/an-overview-of-the-clinical-uses-pharmacology-and-safety-of-modafinil
#20
Eric Murillo-Rodríguez, André Barciela Veras, Nuno Barbosa Rocha, Henning Budde, Sérgio Machado
Modafinil (MOD) is a wakefulness-inducing compound prescribed for treatment of excessive daytime sleepiness as a consequence of sleep disturbances such as shift work sleep disorder, obstructive sleep apnea, restless leg syndrome, or narcolepsy. While providing effective results in patients with sleepiness, MOD also produces positive outcomes in the management of fatigue associated with different conditions including depression, cancer, or tiredness in military personnel. Although there is clear evidence of the stimulant effects of MOD, current data also show that administration of this drug apparently induces positive neurobiological effects, such as improvement in memory...
February 21, 2018: ACS Chemical Neuroscience
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