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Proximal neuropathy

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https://www.readbyqxmd.com/read/29754844/quantitative-magnetic-resonance-imaging-analysis-of-the-cross-sectional-areas-of-the-anconeus-epitrochlearis-muscle-cubital-tunnel-and-ulnar-nerve-with-the-elbow-in-extension-in-patients-with-and-without-ulnar-neuropathy
#1
Hing Y Eng, Drew A Gunio, Carlos L Benitez
BACKGROUND: The purpose of this study was to assess the cross-sectional area of the anconeus epitrochlearis muscle (AEM), cubital tunnel, and ulnar nerve with the elbow in extension in patients with and without ulnar neuropathy. METHODS: We performed a retrospective, level IV review of elbow magnetic resonance imaging (MRI) studies. Elbow MRI studies of 32 patients with an AEM (26 men and 6 women, aged 18-60 years), 32 randomly selected patients without an AEM (aged 16-71 years), and 32 patients with clinical ulnar neuritis (22 men and 10 women, aged 24-76 years) were reviewed...
May 10, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29729473/anatomical-variation-in-a-patient-with-lateral-femoral-cutaneous-nerve-entrapment-neuropathy
#2
Rinko Kokubo, Kyongsong Kim, Daijiro Morimoto, Toyohiko Isu, Naotaka Iwamoto, Takao Kitamura, Akio Morita
This 53-year-old man had a 10-year history of paresthesia and pain in the right antero-lateral thigh exacerbated by prolonged standing and walking. His symptoms improved completely but transiently by lateral femoral cutaneous nerve (LFCN) block. The diagnosis was LFCN entrapment (LFCN-EN). As additional treatment with drugs and repeat LFCN block was ineffective, we performed surgical decompression under local anesthesia. A nerve stimulator located the LFCN 4.5 cm medial to the anterior superior iliac spine, it formed a sharp curve and was embedded in connective tissue...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29726777/surgical-outcomes-after-reoperation-for-recurrent-skull-base-meningiomas
#3
Stephen T Magill, David S Lee, Adam J Yen, Calixto-Hope G Lucas, David R Raleigh, Manish K Aghi, Philip V Theodosopoulos, Michael W McDermott
OBJECTIVE Skull base meningiomas are surgically challenging tumors due to the intricate skull base anatomy and the proximity of cranial nerves and critical cerebral vasculature. Many studies have reported outcomes after primary resection of skull base meningiomas; however, little is known about outcomes after reoperation for recurrent skull base meningiomas. Since reoperation is one treatment option for patients with recurrent meningioma, the authors sought to define the risk profile for reoperation of skull base meningiomas...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29724652/a-novel-homozygous-ndrg1-mutation-in-a-chinese-patient-with-charcot-marie-tooth-disease-4d
#4
Bin Chen, Songtao Niu, Na Chen, Hua Pan, Xingao Wang, Zaiqiang Zhang
Charcot-Marie-Tooth disease 4D (CMT4D) is characterized by severe peripheral neuropathy and deafness. It is caused by mutations in the N-myc downstream-regulated gene 1 (NDRG1). We report a Chinese man with a homozygous mutation c.675C > T of NDRG1 that resulted in Q185X, representing the third known CMT4D patient of non-European ancestry. The patient presented with a 15-year-long history of progressive limb weakness accompanied by hearing loss and dysarthria. There was abnormal differentiation and increased interpeak latencies in brainstem auditory evoked potentials...
April 30, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29713193/supracondylar-process-syndrome-two-cases-of-median-nerve-neuropathy-due-to-compression-by-the-ligament-of-struthers
#5
Hyun-Chul Shon, Ji-Kang Park, Dong-Soo Kim, Sang-Woo Kang, Kook-Jong Kim, Seok-Hyun Hong
The supracondylar process is a beak-shaped bony process on the anteromedial aspect of the distal humerus. The ligament of Struthers is a fibrous band extending from the tip of the process to the medial epicondyle. The median nerve and brachial artery pass under the ligament of Struthers and consequently can be compressed, causing supracondylar process syndrome. As a rare cause of proximal median nerve entrapment, supracondylar process syndrome is triggered when the median nerve is located in the superficial or deep layer of the ligament of Struthers as a result of anatomical variation...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29709457/diabetic-peripheral-neuropathy-epidemiology-diagnosis-and-pharmacotherapy
#6
REVIEW
Zohaib Iqbal, Shazli Azmi, Rahul Yadav, Maryam Ferdousi, Mohit Kumar, Daniel J Cuthbertson, Jonathan Lim, Rayaz A Malik, Uazman Alam
PURPOSE: Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy worldwide, and its prevalence increases with the duration of diabetes. It affects approximately half of patients with diabetes. DPN is symmetric and predominantly sensory, starting distally and gradually spreading proximally in a glove-and-stocking distribution. It causes substantial morbidity and is associated with increased mortality. The unrelenting nature of pain in this condition can negatively affect a patient's sleep, mood, and functionality and result in a poor quality of life...
April 27, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29690828/evidence-for-increased-mri-signal-intensity-and-morphological-changes-in-the-brachial-plexus-and-median-nerves-of-patients-with-chronic-arm-and-neck-pain-following-whiplash-injury
#7
Jane Greening, Kamakshi Anantharaman, Rupert Young, Andrew Dilley
Study Design Cross-sectional study. Background Whiplash following a motor vehicle accident can result in chronic neck and arm pain. Patients frequently present with cutaneous hypersensitivities and hypoesthesia but without obvious clinical sign of nerve injury. T2-weighted magnetic resonance imaging (MRI) has previously been used to identify nerve pathology. Objectives To determine whether there are signs of peripheral nerve pathology on MRI in patients with chronic arm and neck pain following whiplash injury...
April 24, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29657892/inversion-recovery-sequences-improve-delineation-of-optic-pathways-in-the-proximity-of-suprasellar-lesions
#8
Herwin Speckter, José Bido, Giancarlo Hernandez, Diones Rivera, Luis Suazo, Santiago Valenzuela, Rafael Fermin, Jairo Oviedo, Bernd Foerster, Cesar Gonzalez, Peter Stoeter
Introduction: In Gamma Knife Radiosurgery (GKRS) of suprasellar lesions, the exact localization of the visual pathways is important to avoid radiation induced optic neuropathy (RION). Reliable identification of the optic nerve, chiasm and tracts can be challenging using routine magnetic resonance imaging, especially in patients with lesions compressing the optic structures or in patients who had prior operation of suprasellar tumors. This study investigates the application of inversion recovery sequences (Fast gray and white matter acquisition T1 inversion recovery, FGATIR) to improve identification of the optic pathway...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29622409/optimal-measurement-level-and-ulnar-nerve-cross-sectional-area-cutoff-threshold-for-identifying-ulnar-neuropathy-at-the-elbow-by-mri-and-ultrasonography
#9
Yasushi Terayama, Shigeharu Uchiyama, Kazuhiko Ueda, Nahoko Iwakura, Shota Ikegami, Yoshiharu Kato, Hiroyuki Kato
PURPOSE: Imaging criteria for diagnosing compressive ulnar neuropathy at the elbow (UNE) have recently been established as the maximum ulnar nerve cross-sectional area (UNCSA) upon magnetic resonance imaging (MRI) and/or ultrasonography (US). However, the levels of maximum UNCSA and diagnostic cutoff values have not yet been established. We therefore analyzed UNCSA by MRI and US in patients with UNE and in controls. METHODS: We measured UNCSA at 7 levels in 30 patients with UNE and 28 controls by MRI and at 15 levels in 12 patients with UNE and 24 controls by US...
April 3, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29562484/foot-drop-caused-by-a-movable-cystic-mass-during-knee-motion
#10
Nack Hwan Kim, Sang-Heon Lee
BACKGROUND: Nerve injury due to a movable cystic mass during knee motion is a rare neuropathy, which can be diagnosed precisely using a dynamic ultrasonogram. OBJECTIVE: To present a case with foot drop and common peroneal neuropathy that involved a movable cystic mass during knee flexion adjacent to the proximal tibiofibular joint. METHODS: Case report. RESULTS: A 47-year-old female was referred to our institute for a right foot drop...
March 9, 2018: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29559376/risk-of-mortality-after-resolution-of-spinal-malperfusion-in-acute-dissection
#11
Harleen K Sandhu, Kristofer M Charlton-Ouw, Katherine Jeffress, Samuel Leake, Alexa Perlick, Charles C Miller, Ali Azizzadeh, Hazim J Safi, Anthony L Estrera
BACKGROUND: Patients presenting with acute aortic dissection may develop spinal cord ischemia (SCI). We sought to determine how SCI and its recovery affects outcomes. METHODS: We reviewed patients with SCI in acute type A aortic dissection (ATAAD) and acute type B aortic dissection (ATBAD) from September 1999-May 2014. SCI was defined as paraplegia or paraparesis present on admission. Monoparesis/plegia, paraesthesia, or numbness was defined as ischemic neuropathy (IN)...
March 17, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29552439/the-natural-history-of-hereditary-motor-and-sensory-neuropathy-with-proximal-dominant-involvement-hmsn-p-in-97-japanese-patients
#12
Natsumi Fujisaki, Shugo Suwazono, Masahito Suehara, Ryo Nakachi, Miwako Kido, Yoshihisa Fujiwara, Saki Oshiro, Takashi Tokashiki, Hiroshi Takashima, Masanori Nakagawa
Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is a motor and sensory neuronopathy with autosomal dominant inheritance, adult onset, slowly progressive course, and is associated with TRK-fused gene (TFG) mutation. At advanced stages, respiratory failure and dysphagia becomes life-threatoning, and patients typically die by their 70s. Although there is currently no evidence for effective treatment, a therapy may be found by elucidation of the function of TFG. Recently its pathomechanism has been proposed to be associated with abnormalities in protein transfer from the endoplasmic reticulum...
February 2018: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29526115/sensory-profiles-are-comparable-in-patients-with-distal-and-proximal-entrapment-neuropathies-while-the-pain-experience-differs
#13
Brigitte Tampin, Jan Vollert, Annina B Schmid
OBJECTIVE: Distal and proximal entrapment neuropathies such as carpal tunnel syndrome (CTS) and cervical radiculopathy (CR) share similar etiologies. Experimental models suggest that, despite comparable etiology, pathomechanisms associated with injuries of the peripheral and central axon branches are distinct. This study therefore compared self-reported and elicited sensory profiles in patients with distal and proximal entrapment neuropathies. METHODS: Patients with electrodiagnostically confirmed CTS (n = 103) and patients with CR (n = 23) were included in this study...
April 13, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29465610/col6a-and-lama2-mutation-congenital-muscular-dystrophy-a-clinical-and-electrophysiological-study
#14
Sumit Verma, Parul Goyal, Lokesh Guglani, Charlotte Peinhardt, Diane Pelzek, Paul E Barkhaus
OBJECTIVES: COL6A and LAMA2 are subtypes of congenital muscular dystrophy. METHODS: Retrospective chart review of clinical findings, spirometry, muscle histology, muscle ultrasound, neuroimaging, and Electromyography (EMG)/Nerve Conduction Study data in genetically confirmed COL6A and LAMA2 subjects. RESULTS: We identified 8 COL6A and 6 LAMA2 subjects: the female-to-male ratio was 1.3:1 and the mean age was 11.9 ± 3.6 years. Gross motor delays since birth, proximal muscle weakness, and contractures were noted in both groups...
March 2018: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29459766/greater-corneal-nerve-loss-at-the-inferior-whorl-is-related-to-the-presence-of-diabetic-neuropathy-and-painful-diabetic-neuropathy
#15
Alise Kalteniece, Maryam Ferdousi, Ioannis Petropoulos, Shazli Azmi, Safwaan Adam, Hassan Fadavi, Andrew Marshall, Andrew J M Boulton, Nathan Efron, Catharina G Faber, Giuseppe Lauria, Handrean Soran, Rayaz A Malik
We assessed whether a measure of more distal corneal nerve fibre loss at the inferior whorl(IW) region is better than proximal measures of central corneal nerve damage in relation to the diagnosis of diabetic peripheral neuropathy(DPN), painful DPN and quality of life(QoL). Participants underwent detailed assessment of neuropathy, QoL using the SF36 questionnaire, pain visual analogue score(VAS), and corneal confocal microscopy(CCM). Corneal nerve fibre density (CNFD), branch density (CNBD) and length (CNFL) at the central cornea and inferior whorl length (IWL) and average(ANFL) and total(TNFL) nerve fibre length were compared in patients with and without DPN and between patients with and without painful DPN and in relation to QoL...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29454964/nek3-mediated-snap29-phosphorylation-modulates-its-membrane-association-and-snare-fusion-dependent-processes
#16
Debora Rapaport, Boris Fichtman, Hilla Weidberg, Eli Sprecher, Mia Horowitz
Intracellular membrane fusion depends on the presence of specific mediators, the vesicle (v-) and the target (t-) SNAREs (Soluble N-ethylmaleimide-sensitive factor, NSF, attachment protein SNAP receptors), whose interaction brings apposing membranes to close proximity and initiates their fusion. SNAP29 (synaptosomal-associated protein 29), a t-SNARE protein, is involved in multiple fusion events during intracellular transport and affects structure of organelles such as the Golgi apparatus and focal adhesions...
March 4, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29427450/reconstruction-of-the-plantar-toe-with-a-distal-reverse-instep-sensory-island-flap
#17
Mohammad Ali Hosseinian, Ali Gharibi Loron, Behzad Nemati Honar
BACKGROUND: Plantar toe ulcers are a challenging surgical problem. There are several methods for reconstruction, but no attention has been given to the preservation of sensation. This report proposes a method to provide protective sensation for the reconstructed area. PATIENTS AND METHODS: The ulcers of seven patients ranged from 2 × 3 to 7 × 3 cm with defects of the plantar first toe and distal metatarsus, including four burns, a trauma, a diabetic ulcer, and a neuropathy injury reconstructed with a distal reverse instep sensory island (DRISI) flap...
February 10, 2018: Microsurgery
https://www.readbyqxmd.com/read/29406910/immunohistochemistry-and-electrophysiological-findings-in-swine-abattoir-workers-with-immune-mediated-polyradiculoneuropathy
#18
Suraj A Muley, Stacy Holzbauer, Brent Clark, James Sejvar, Ruth Lynfield, Gareth Parry, Aaron S DeVries
IMPORTANCE: Workers exposed to aerosolized brain in a swine-processing plant developed immune-mediated polyradiculoneuropathy (IP) possibly triggered by an immune response. OBJECTIVE: Immunohistochemistry results were correlated with electrophysiological variables to examine the immunopathogenesis of this disorder. DESIGN/SETTING: Laboratory studies used normal nerve tissue that was exposed to sera from 12 IP patients; 10 exposed controls; and 10 unexposed controls...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29396836/wes-homozygosity-mapping-in-a-recessive-form-of-charcot-marie-tooth-neuropathy-reveals-intronic-gdap1-variant-leading-to-a-premature-stop-codon
#19
Marion Masingue, Jimmy Perrot, Robert-Yves Carlier, Guenaelle Piguet-Lacroix, Philippe Latour, Tanya Stojkovic
Charcot-Marie-Tooth disease (CMT) refers to a group of clinically and genetically heterogeneous inherited neuropathies. Ganglioside-induced differentiation-associated protein 1 GDAP1-related CMT has been reported in an autosomal dominant or recessive form in patients presenting either axonal or demyelinating neuropathy. We report two Sri Lankan sisters born to consanguineous parents and presenting with a severe axonal sensorimotor neuropathy. The early onset of the disease, the distal and proximal weakness and atrophy leading to major disability, along with areflexia, and, most notably, vocal cord and diaphragm paralysis were highly evocative of a GDAP1-related CMT...
February 2, 2018: Neurogenetics
https://www.readbyqxmd.com/read/29369099/lymphangiomatous-tumors-of-the-neck-tips-to-avoid-iatrogenic-nerve-injuries-in-the-brachial-plexus-region
#20
Jerry Tsung-Kai Lin, Johnny Chuieng-Yi Lu, Yenlin Huang, Tommy Nai-Jen Chang, David Chwei-Chin Chuang
Lymphangiomas are rare malformations of the lymphatic system and can often be found in the neck region, where its proximity to the brachial plexus may cause compressive neuropathy and possible iatrogenic injuries during dissection. We report 4 cases of lymphangiomas with compression of the brachial plexus that were successfully removed without permanent nerve injuries and present a literature review of the preoperative approach and surgical techniques. A preoperative multidisciplinary approach can help surgeons predict what they may encounter during the surgery...
January 24, 2018: Annals of Plastic Surgery
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