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Michail Mitsis, Panagiotis Koliou, Christina Bali, Evangelia Ntounousi, Vasileios Tatsis, Vasileios Nousias, Georgios D Lianos, Georgios Vartholomatos, Dimitrios Nastos
Background/Purpose: In colon cancer (CC) patients preoperative (pre-op) levels of VEGF-A165 (VEGF) is a strong predictor for disease recurrence. Elevated postoperative (post-op) VEGF levels could have undesirable effects by enhancing tumor growth and metastasis formation. It has been suggested that thromboprophylaxis with a Low Molecular Weight Heparin (LMWH) in surgical cancer patients, further to thromboembolic protection, may exert some anti-neoplastic properties, as well. The aim of our study was to assess the potential impact of the LMWH Tinzaparin (Innohep® - Leo Pharma, Copenhagen, Denmark), given at different doses and for different perioperative (peri-op) periods, upon the post-op variability of serum VEGF levels in surgical CC patients...
2017: Journal of Cancer
Harshavardhan B Rao, Hasim Ahamed, Suprabha Panicker, Surendran Sudhindran, Rama P Venu
AIM: To identify factors predicting outcome of endoscopic therapy in bile duct strictures (BDS) post living donor liver transplantation (LDLT). METHODS: Patients referred with BDS post LDLT, were retrospectively studied. Patient demographics, symptoms (Pruritus, Jaundice, cholangitis), intra-op variables (cold ischemia time, blood transfusions, number of ducts used, etc.), peri-op complications [hepatic artery thrombosis (HAT), bile leak, infections], stricture morphology (length, donor and recipient duct diameters) and relevant laboratory data both pre- and post-endotherapy were studied...
May 15, 2017: World Journal of Gastrointestinal Pathophysiology
Peter G Passias, Gregory W Poorman, Cyrus M Jalai, Breton Line, Bassel Diebo, Paul Park, Robert Hart, Douglas Burton, Frank Schwab, Virginie Lafage, Shay Bess, Thomas Errico
BACKGROUND CONTEXT: Adult spinal deformity (ASD) represents a constellation of complex malalignments affecting the spinal column. Corrective surgical procedures aimed at improving ASD can be equally challenging, and commonly require multiple index procedures and potential revisions before definitive management. There is a paucity of data comparing the outcomes of same-day(simultaneous [SIM]) and 2-day (staged [STA]) procedures for long spinal fusions for ASD. Using a large patient cohort with surgeon- and patient-reported outcomes will be particularly useful in determining the utility and effect of staging long spinal fusions for ASD...
March 21, 2017: Spine Journal: Official Journal of the North American Spine Society
Sheliang Shen, Jun Zhang, Wenyuan Wang, Jiayin Zheng, Yihong Xie
BACKGROUND: Intra-operative cell salvage (CS) was reported to have no impairment on blood coagulation in low-bleeding-risk cardiac surgery with cardiopulmonary bypass (CPB), but studies in high-bleeding-risk cardiac surgery are limited. The objective of this study is to evaluate the impact of CS on blood coagulation in high-bleeding-risk cardiac surgery with CPB. METHODS: One hundred and ten patients were randomly assigned to either with intra-operative CS group (Group CS) or without intra-operative CS group (Group C)...
July 29, 2016: Journal of Translational Medicine
M J Jackson, C Patvardhan, F Wallace, A Martin, H Yusuff, G Briggs, R A Malik
BACKGROUND: Ten percent of elective surgical patients have diabetes. These patients demonstrate excess perioperative morbidity and mortality. National guidance on the management of adults with diabetes undergoing surgery was published in 2011. We present a region-wide audit of adherence to this guidance across the North Western Deanery. METHODS: Local teams prospectively collected data according to a locally approved protocol. Pregnant, paediatric and non-elective patients were excluded from this audit...
April 2016: British Journal of Anaesthesia
Per D Trobisch, Steven W Hwang, Steffen Drange
PURPOSE: A decompensated sagittal imbalance has been associated with worsening health-related quality of life outcomes and increasing pain. Significant improvement in sagittal balance can be achieved using a pedicle subtraction osteotomy (PSO); however, this procedure has a high complication profile. A lumbar PSO has the advantages of direct visualization of all neural structures and safer retraction of the thecal sac. Sacrificing neuromonitoring may reduce anaesthesia time and lead to improved cost effectiveness of the surgery...
August 2016: European Spine Journal
Shane Burch, Michael Feldstein, Paul F Hoffmann, Tony M Keaveny
STUDY DESIGN: Retrospective, cross-sectional analysis of vertebral bone quality in spine-fusion patients at a single medical center. OBJECTIVE: To characterize the prevalence of osteoporosis and fragile bone strength in a spine-fusion population of women with an age range of 50 years to 70 years. Fragile bone strength is defined as the level of vertebral strength below which a patient is at as high a risk of future vertebral fracture as a patient having bone density-defined osteoporosis...
February 2016: Spine
Mariola Janiszewska, Teresa Kulik, Małgorzata A Dziedzic, Dorota Żołnierczuk-Kieliszek
INTRODUCTION: Osteoporosis as a chronic disease, affecting especially women in postmenopausal age, is an important, social and economic health problem especially of women of today's world. The aim of the study was to assess the level of knowledge of women in the peri- and postmenopausal period about the prevention of osteoporosis and show the influence of chosen risk factors on the level of this knowledge. MATERIAL AND METHODS: A group of 300 women aged 45-65, being patients of healthcare centres in Chełm, Lublin and Zamość (Lublin voivodeship, south-eastern Poland) were included in the study...
March 2015: Przeglad Menopauzalny, Menopause Review
Tuncay Yüce, Erkan Kalafat, Acar Koc
OBJECTIVE: The present study aims to determine the effects of a history of adolescent pregnancy (AP) on the bone mineral density (BMD) of perimenopausal women. METHODS: Overall, 240 women aged between 40 and 55 years, with a complaint of oligomenorrhea or amenorrhea not exceeding 1 year in duration, were evaluated. Evaluation included a DEXA scan and a detailed demographic survey for bone health. Comparison was made between women with a history of AP and those without...
October 2015: Maturitas
Elizabeth Merlin-Manton, Michelle Greenwood, Adele Linthwaite
Following the work of Winter demonstrating the benefits of moist wound healing, there has been a constant stream of wound care products launched into the market to support this concept. This article will describe the findings of an observational evaluation to observe, document and analyse the clinical effectiveness of a new foam adhesive dressing, UrgoTul® Absorb Border (Urgo Medical). The main objective of the evaluation was to define the parameters to allow data capture that would demonstrate the clinical effectiveness of the dressing...
August 13, 2015: British Journal of Nursing: BJN
Mohammad Sabir, Mohammad Nazish Alam
BACKGROUND: The aims and objectives of this study were placement of implants in freshly extracted sockets of anterior teeth and to evaluate the implant stability, peri-implant radiolucency and gingival inflammation around implant over a short period of 30 months. MATERIALS AND METHODS: A total of 12 patients (8 male and 4 female), ranging in the age from 20 to 50 years, from March 2007 to June 2007, were evaluated for immediate implant placement into 22 fresh extraction sockets...
June 2015: Journal of Clinical and Diagnostic Research: JCDR
Angela María Magali Sanchez, Natalia Pampillón, Mariela Abaurre, Pablo Esteban Omelanczuk
INTRODUCTION: chronic inflammation induced by obesity alters iron homeostasis leading to mild /moderate iron deficiency and anaemia. Between 14% and 43% of patients may suffer from iron deficiency without anaemia before surgery. The management of peri-operative iron deficiency improves patient outcome and quality of life. Under certain circumstances intravenous (IV) iron must be considered. IV iron (which may avoid iron blockage in enterocytes and macrophages) has turned out to be a safe and efficient alternative...
July 1, 2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Fiona Peris-Sampedro, Maria Cabré, Pia Basaure, Ingrid Reverte, José L Domingo, Maria Teresa Colomina
Increasing evidence links the widespread exposure to organophosphate (OP) pesticides to the global epidemics of type 2 diabetes and obesity. Our recent data highlighted gene×environment interactions: mice expressing the human apolipoprotein E3 (apoE3) isoform were more prone to develop obesity than those expressing apoE2 or apoE4 upon dietary challenge with chlorpyrifos (CPF), the most used OP worldwide. Thus, we aimed to further explore the contribution of the APOE3 genotype on the emergence of obesity and related metabolic dysfunctions upon subchronic exposure to CPF...
October 2015: Environmental Research
Juliane Menzel, Romina di Giuseppe, Angelika Wientzek, Anja Kroke, Heiner Boeing, Cornelia Weikert
Physical activity (PA) is suggested to increase the peak bone mass and to minimize age-related bone loss, and thereby to reduce the risk of osteoporosis. However, the relation between PA and bone health considering the obesity status is unclear so far. The present study examines the association between PA levels and calcaneal broadband ultrasound attenuation (BUA), particularly under consideration of obesity. Data from a population-based sample of 6776 German women from the EPIC-Potsdam cohort were analyzed...
October 2015: Calcified Tissue International
B Fibbi, S Benvenuti, C Giuliani, C Deledda, P Luciani, M Monici, B Mazzanti, C Ballerini, A Peri
Hyponatremia represents an independent risk factor for osteoporosis and fractures, affecting both bone density and quality. A direct stimulation of bone resorption in the presence of reduced extracellular sodium concentrations ([Na(+)]) has been shown, but the effects of low [Na(+)] on osteoblasts have not been elucidated. We investigated the effects of a chronic reduction of extracellular [Na(+)], independently of osmotic stress, on human mesenchymal stromal cells (hMSC) from bone marrow, the common progenitor for osteoblasts and adipocytes...
April 2016: Endocrine
L Gifre, J Vidal, J L Carrasco, A Muxi, E Portell, A Monegal, N Guañabens, P Peris
UNLABELLED: Spinal cord injury (SCI) has been associated with a marked bone loss after injury and a consequent increased risk of osteoporosis. The evaluation of bone mineral density shortly after SCI is a simple and effective method for predicting the development of osteoporosis during the first year after SCI. INTRODUCTION: Spinal cord injury (SCI) has been associated with a marked bone loss after injury and a consequent increased risk of osteoporosis and fractures...
September 2015: Osteoporosis International
Abu Bakar Hafeez Bhatti, Muhammad Aasim Yosuf, Aamir Ali Syed
OBJECTIVE: To share a single-centre experience with radical resection of adenocarcinoma of the second part of duodenum. METHODS: The retrospective review was conducted at Shaukat Khanum Memorial Cancer Hospital, Lahore, and comprised data of patients who underwent pancreaticoduodenal resection for duodenal adenocarcinoma from January 1999 to December 2012. Patient characteristics and histopathological variables were assessed. Post-op complications, median disease-free span and overall survival were assessed...
November 2014: JPMA. the Journal of the Pakistan Medical Association
G Ramalho-Ferreira, L P Faverani, F B Prado, I R Garcia, R Okamoto
The aim of this study was to evaluate bone healing at the bone-implant interface in rats with induced osteoporosis. The rats underwent a bilateral ovariectomy (OVX) and were fed a low calcium and phosphate diet. The OVX rats were divided into three groups: one was treated with raloxifene (OVX-RAL), one with alendronate (OVX-ALE), and one received no medication (OVX-NT). The control group rats (SHAM-DN) underwent sham surgery and were fed a normal diet. Each animal received one implant in each tibia: a machined surface implant in the right tibia and an implant with surface etching in the left tibia...
June 2015: International Journal of Oral and Maxillofacial Surgery
Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli
AIM: To assess the failure and bone-to-implant contact rate of dental implants placed on osteoporotic subjects. METHODS: Extensive examination strategies were created to classify studies for this systematic review. MEDLINE (via PubMed) and EMBASE database were examined for studies in English up to and including May 2014. The examination presented a combination of the MeSH words described as follow: "osteoporosis" or "osteopenia" or "estrogen deficiency" AND "implant" or "dental implant" or "osseointegration"...
March 18, 2015: World Journal of Orthopedics
Michalis N Gionis, Christos V Ioannou, Nikolaos Kontopodis, Konstantinos Balalis, Ismail Elalamy, Grigoris T Gerotziafas
BACKGROUND: Aim. The aim of this study was to investigate biological resistance to enoxaparin and rebound effect after prophylaxis withdrawal, using thrombin generation (TG) assay. METHODS: Fifteen-patients undergoing femoro-popliteal bypass grafting (enoxaparin 4000 antiXaIU+75 mg clopidogrel), and 15-patients undergoing total-hip-replacement (THR) (enoxaparin alone). TG-assay parameters (lag-time, endogenous-thrombin-potential, peak-, time-to-peak, and Mean-Rate-Index) were assessed to investigate heparin resistance and rebound effect after prophylaxis interruption...
April 2016: International Angiology: a Journal of the International Union of Angiology
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