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https://www.readbyqxmd.com/read/28325005/dynamic-modeling-of-apnea-induced-concurrent-variations-in-arterial-blood-pressure-and-cerebral-blood-flow-velocity
#1
Raichel Alex, Rong Zhang, Donald E Watenpaugh, Khosrow Behbehani
Obstructive Sleep Apnea (OSA) is characterized by partial (hypopnea) or complete cessation (apnea) of airflow to the lungs during sleep. It has been previously reported that apnea episodes lead to significant rise in instantaneous blood pressure concomitant with a rise in cerebral blood flow velocity, indicating loss of cerebral autoregulation during the episodes. In this study, we have used Auto Regressive Moving Average model (ARMA (na, nb, nk)) to quantify OSA induced dynamic changes in cerebral blood flow velocity (CBFV) with beat to beat blood pressure (BP) as an input...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28300569/obesity-as-an-effect-modifier-in-sleep-disordered-breathing-and-post-cardiac-surgery-atrial-fibrillation
#2
Roop Kaw, Samer El Zarif, Lu Wang, James Bena, Eugene Blackstone, Reena Mehra
INTRODUCTION: As the inter-relationships of objectively-ascertained sleep disordered breathing (SDB), post-cardiac surgery atrial fibrillation (PCSAF) and obesity remain unclear; we aimed to further investigate in a clinic-based cohort. METHODS: Patients with polysomnography (PSG) and cardiac surgery (coronary artery bypass surgery and/or valvular surgery) within 3 years, from January 2009 to January 2014 were identified excluding those with pre-existing AF. Logistic models were used to determine the association of SDB (apnea hypopnea index (AHI) per 5 unit increase) and secondary predictors [central sleep apnea (CSA) (central apnea index>5) and oxygen desaturation index (ODI)] with PCSAF...
March 11, 2017: Chest
https://www.readbyqxmd.com/read/28299255/changes-in-posterior-airway-space-and-mandibular-plane-hyoid-distance-following-mandibular-advancement-do
#3
Pushpa Kumari, S K Roy, Indranil Dev Roy, A K Rajput, M P Prasanna Kumar, Sanjeev Datana, Serat Rahman
AIM: To study the changes in posterior airway space (PAS) and mandibular plane hyoid (MPH) distance following mandibular advancement using distraction osteogenesis (DO). SUBJECTS AND METHODS: A prospective study was conducted at a tertiary care dental center from May 2009 to May 2014. Twenty-five consecutively operated patients of mandibular hypoplasia who underwent mandibular advancement using distraction with at least 12 months follow-up were included in the study...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28279153/the-association-between-biochemical-control-and-cardiovascular-risk-factors-in-acromegaly
#4
John D Carmichael, Michael S Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P Neary, Vivien Bonert
BACKGROUND: The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors. METHODS: Data were from a single-center acromegaly registry. Study patients were followed for ≥12 months after initial treatment. Study period was from first to last insulin-like growth factor-I and growth hormone tests. RESULTS: Of 121 patients, 55% were female...
March 9, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28269229/a-study-of-apnea-induced-covariations-of-cerebral-blood-flow-and-exhaled-co2
#5
Varun Kanal, Raichel Alex, Nazaneen Mousavi, Kevin Jepsen, Donald E Watenpaugh, Rong Zhang, Khosrow Behbehani
Sleep apnea is identified by repetitive reduction or complete cessation of breathing during sleep. Sleep apnea affects cerebral hemodynamics and it is important to study this effect. Measuring cerebral blood flow during sleep is challenging due to the need to maintain a contact between the flow probe and the skull. It is hypothesized that there exists a relationship between the variations in the exhaled CO2 and Cerebral Blood Flow during sleep apnea. To test this hypothesis, the present study was conducted in two parts: simulated and nocturnal sleep study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28255913/body-composition-anthropometric-indices-and-hydration-status-of-obstructive-sleep-apnea-patients-can-cachexia-coexist-with-obesity
#6
Barbara Kuźnar-Kamińska, Marcin Grabicki, Tomasz Trafas, Monika Szulińska, Szczepan Cofta, Tomasz Piorunek, Beata Brajer-Luftmann, Agata Nowicka, Barbara Bromińska, Halina Batura-Gabryel
The aim of this study was to elucidate body composition, anthropometric indices, and hydration status in obstructive sleep apnea (OSA) patients, taking into account different disease stages, gender, and the possibility of the presence of cachexia. There were 98 OSA patients and 23 control subjects enrolled into the study. All study participants underwent polysomnography examination. Body mass index (BMI), fat mass index (FMI), fat free mass, muscle mass, body cell mass, total body water, and extracellular and intracellular water were evaluated...
March 3, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28227461/dynamic-modeling-of-apnea-induced-concurrent-variations-in-arterial-blood-pressure-and-cerebral-blood-flow-velocity
#7
Raichel Alex, Rong Zhang, Donald E Watenpaugh, Khosrow Behbehani, Raichel Alex, Rong Zhang, Donald E Watenpaugh, Khosrow Behbehani, Raichel Alex, Rong Zhang, Khosrow Behbehani, Donald E Watenpaugh
Obstructive Sleep Apnea (OSA) is characterized by partial (hypopnea) or complete cessation (apnea) of airflow to the lungs during sleep. It has been previously reported that apnea episodes lead to significant rise in instantaneous blood pressure concomitant with a rise in cerebral blood flow velocity, indicating loss of cerebral autoregulation during the episodes. In this study, we have used Auto Regressive Moving Average model (ARMA (na, nb, nk)) to quantify OSA induced dynamic changes in cerebral blood flow velocity (CBFV) with beat to beat blood pressure (BP) as an input...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227460/a-study-of-apnea-induced-covariations-of-cerebral-blood-flow-and-exhaled-co2
#8
Varun Kanal, Raichel Alex, Nazaneen Mousavi, Kevin Jepsen, Donald E Watenpaugh, Rong Zhang, Khosrow Behbehani, Varun Kanal, Raichel Alex, Nazaneen Mousavi, Kevin Jepsen, Donald E Watenpaugh, Rong Zhang, Khosrow Behbehani, Raichel Alex, Rong Zhang, Khosrow Behbehani, Donald E Watenpaugh, Kevin Jepsen, Varun Kanal, Nazaneen Mousavi
Sleep apnea is identified by repetitive reduction or complete cessation of breathing during sleep. Sleep apnea affects cerebral hemodynamics and it is important to study this effect. Measuring cerebral blood flow during sleep is challenging due to the need to maintain a contact between the flow probe and the skull. It is hypothesized that there exists a relationship between the variations in the exhaled CO2 and Cerebral Blood Flow during sleep apnea. To test this hypothesis, the present study was conducted in two parts: simulated and nocturnal sleep study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224726/a%C3%A4-rway-and-sleep-d%C3%A4-sorders-%C3%A4-n-pat%C3%A4-ents-w%C3%A4-th-acromegaly
#9
Onur Turan, Barış Akıncı, Ahmet Omer Ikız, Oya Itıl, Ibrahim Oztura, Emel Ada, Bahri Akdenız, Serkan Yener, Murat Kaya, Arzu Gedık, Abdurrahman Comlekcı
INTRODUCTION-OBJECTIVE: Acromegaly is a multisystemic disorder caused by excessive secretion of growth hormone (GH). Sleep-disordered breathing (SDB) such as sleep apnea syndrome (SAS) may occur in acromegaly. The aim of study was to assess the presence of sleep disorders and evaluate the systemic complications on respiratory, cardiovascular and upper airway systems in acromegalic patients. METHODS: The study group consisted of 30 acromegaly outpatients. GH and insulin-like growth factor 1 (IGF-1) measurements were obtained; body pletysmography, arterial blood gas analysis,tissue-doppler imaging,echocardiography,polysomnography,otorhinolaryngologic examination and head-neck computed tomography were performed...
February 22, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28211992/thirty-day-outcomes-for-children-and-adolescents-undergoing-laparoscopic-sleeve-gastrectomy-at-a-free-standing-children-s-hospital
#10
A L Speer, J Parekh, F G Qureshi, E P Nadler
The obesity epidemic continues to affect millions of children and adolescents. Non-surgical options do not result in significant or sustained weight loss; thus bariatric surgery has become increasingly utilized. Limited data exist regarding safety for paediatric bariatric surgery, especially outside of National Institutes of Health (NIH)-funded centres. We hypothesized that the perioperative outcomes of paediatric patients undergoing laparoscopic sleeve gastrectomy (LSG) at our free-standing children's hospital would provide adequate safety profiles...
April 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28197893/gender-differences-in-clinical-and-polysomnographic-features-of-obstructive-sleep-apnea-a-clinical-study-of-2827-patients
#11
Ozen K Basoglu, Mehmet Sezai Tasbakan
PURPOSE: Obstructive sleep apnea (OSA) is underdiagnosed in females due to different clinical presentation. We aimed to determine the effect of gender on clinical and polysomnographic features and identify predictors of OSA in women. METHODS: Differences in demographic, clinical, and polysomnographic parameters between 2052 male and 775 female OSA patients were compared. RESULTS: In female OSA patients, age (56.1 ± 9.7 vs. 50.4 ± 11...
February 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28197218/polysomnographic-findings-in-infants-with-pierre-robin-sequence
#12
Abdullah Khayat, Saadoun Bin-Hassan, Suhail Al-Saleh
INTRODUCTION: Pierre Robin sequence (PRS) is characterized by the triad of micrognathia, glossoptosis, and upper airway obstruction. It is commonly associated with the secondary cleft palate. Infants with PRS commonly have sleep-disordered breathing (SDB); including obstructive sleep apnea (OSA) as well as central sleep breathing abnormalities that are present from infancy. AIM OF THE STUDY: Evaluate the prevalence and severity of SDB in infants with PRS using polysomnography (PSG)...
January 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28195345/in-vivo-measurements-of-human-neck-skin-elasticity-using-mri-and-finite-element-modeling
#13
Yunqiang An, Changjin Ji, Yong Li, Jianxia Wang, Xinyue Zhang, Yaqi Huang
PURPOSE: The assessment of mechanical properties of the human skin is very important in investigating the mechanism of obstructive sleep apnea, a common disorder characterized by repetitive collapse and obstruction of the upper airway during sleep. In this study, a unique method, combining magnetic resonance imaging (MRI) and finite element modeling (FEM), was developed to obtain the value of the in vivo elastic modulus of the neck skin. MEHTHOD: A total of 22 subjects, 16 males and 6 females, were recruited to participate in the MRI studies...
February 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28134311/prevalence-and-predictors-of-atherogenic-serum-lipoprotein-dyslipidemia-in-women-with-obstructive-sleep-apnea
#14
Yunyan Xia, Yiqun Fu, Yuyu Wang, Yingjun Qian, Xinyi Li, Huajun Xu, Jianyin Zou, Jian Guan, Hongliang Yi, Lili Meng, Xulan Tang, Huaming Zhu, Dongzhen Yu, Huiqun Zhou, Kaiming Su, Shankai Yin
Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, no study has focused on dyslipidemia in women with OSA. The aim of this study was to determine the prevalence and risk factors for dyslipidemia in women with OSA. Between 2007 and 2013, 570 eligible female patients with suspected OSA were consecutively recruited. The analyzed data consisted of polysomnography parameters, biochemical indicators, and anthropometric measurements. Serum lipid levels and dyslipidemia were compared. Binary logistic regression and multivariate linear regression models were used to determine the independent risk factors influencing serum lipids...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28123647/phenotypic-contrasts-of-duchenne-muscular-dystrophy-in-women-two-case-reports
#15
Karen T Nozoe, Ricardo T Akamine, Diego R Mazzotti, Daniel N Polesel, Luís F Grossklauss, Sergio Tufik, Monica L Andersen, Gustavo A Moreira
We discussed two cases of symptomatic female carriers to Duchenne Muscular Dystrophy. The first case is a 20 year-old girl with classical phenotypic manifestation of the disease, similar to the condition in boys. The case 2 is a 62 year-old woman with progressive muscular weakness. The disease is much less common in woman than men so both cases described here are considered rare forms of the disease, with several clinical implications. In both cases, a progressive muscle weakness, impairment in walking and sleeping was observed, in addition to obstructive sleep apnea syndrome and alveolar hypoventilation, that required noninvasive ventilatory support...
July 2016: Sleep Science
https://www.readbyqxmd.com/read/28101630/association-between-sleep-apnea-and-low-bone-mass-in-adults-a-systematic-review-and-meta-analysis
#16
H Eimar, H Saltaji, S Ghorashi, D Isfeld, J E MacLean, D Gozal, D Graf, C Flores-Mir
We performed a systematic review of the literature to assess the association between sleep apnea and bone metabolism diseases including osteoporosis in adult population. Results from clinical trials suggest that the association between sleep apnea and low bone mass in adults is possible. INTRODUCTION: This study aimed to synthesize existing evidence on the potential association between sleep apnea and low bone mass in adults. METHODS: Electronic searches of five databases were performed...
January 18, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28095969/body-fat-distribution-ratios-and-obstructive-sleep-apnea-severity-in-youth-with-obesity
#17
Amy Glicksman, Stasia Hadjiyannakis, Nicholas Barrowman, Scott Walker, Lynda Hoey, Sherri Lynne Katz
STUDY OBJECTIVES: Obesity and regional fat distribution, measured by neck fat mass percentage using dual-energy X-ray absorptiometry (DXA), correlate with obstructive sleep apnea (OSA) severity in adults. In obese children, neck-to-waist-circumference ratio predicts OSA. This study examined associations between body fat percentage and distribution and sleep-disordered breathing (SDB) severity in obese youth, measured with DXA. METHODS: Cross-sectional retrospective study conducted at a tertiary children's hospital...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28090638/late-gestational-intermittent-hypoxia-induces-metabolic-and-epigenetic-changes-in-male-adult-offspring-mice
#18
Abdelnaby Khalyfa, Rene Cortese, Zhuanhong Qiao, Honggang Ye, Riyue Bao, Jorge Andrade, David Gozal
Pregnancy, particularly late gestation, has been associated with a relatively high prevalence of obstructive sleep apnea (OSA). Intermittent hypoxia (IH), a hallmark of OSA, could impose significant long-term effects on somatic growth, energy homeostasis, and metabolic function in offspring. We hypothesized that IH during late pregnancy (LG-IH) may increase the propensity for metabolic dysregulation and obesity in adult offspring via epigenetic modifications. Time-pregnant female C57BL/6 mice were exposed to LG-IH or room air (LG-RA) during days 13-18 of gestation...
January 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28075423/effects-of-device%C3%A2-guided-slow-breathing-training-on-exercise-capacity-cardiac-function-and-respiratory-patterns-during-sleep-in-male-and-female-patients-with-chronic-heart-failure
#19
Kalina Kawecka-Jaszcz, Grzegorz Bilo, Tomasz Drożdż, Dorota Dębicka-Dąbrowska, Grzegorz Kiełbasa, Gabriella Malfatto, Katarzyna Styczkiewicz, Carolina Lombardi, Agnieszka Bednarek, Sabrina Salerno, Danuta Czarnecka, Gianfranco Parati
INTRODUCTION Slow breathing training (SBT) has been proposed as a new nonpharmacologic treatment in patients with chronic heart failure (CHF). OBJECTIVES The aim of this study was to assess the effects of SBT on exercise capacity, hemodynamic parameters, and sleep respiratory patterns in a relatively large sample of CHF patients. PATIENTS AND METHODS A crossover open study was conducted. Patients completed, in a random order, 10- to 12‑week SBT, with 2 15‑minute sessions of device‑guided SBT each day, reaching 6 breaths/ min, and a 10- to 12‑week follow‑up under standard care...
January 10, 2017: Pol Arch Intern Med
https://www.readbyqxmd.com/read/28056799/epidemiological-characteristics-and-gender-specific-differences-of-obstructive-sleep-apnea-in-a-chinese-hypertensive-population-a-cross-sectional-study
#20
Anping Cai, Yingling Zhou, Jiawei Zhang, Qi Zhong, Rui Wang, Ling Wang
BACKGROUND: Obstructive sleep apnea (OSA) is associated with an increase in the prevalence and incidence of hypertension and cardiovascular diseases. Data about epidemiological characteristics of OSA in Chinese hypertensive populations is limited. METHODS: Hypertensive subjects without a prior diagnosis of OSA were recruited, and the apnea-hyponea index (AHI) was assessed by polysomnography. Comparisons were performed between subjects without OSA and with different degrees of OSA...
January 5, 2017: BMC Cardiovascular Disorders
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