Mohammed Ageeli Hakami, Ali Hazazi, Farhan R Khan, Osama Abdulaziz, Khalid Alshaghdali, Adil Abalkhail, Somia A Nassar, Bashir Ibrahim A Omar, Fahad Almarshadi, Gaurav Gupta, Abdulkarim S Binshaya
The lncRNA PVT1 has emerged as a pivotal component in the intricate landscape of cancer pathogenesis, particularly in lung cancer. PVT1, situated in the 8q24 chromosomal region, has garnered attention for its aberrant expression patterns in lung cancer, correlating with tumor progression, metastasis, and poor prognosis. Numerous studies have unveiled the diverse mechanisms PVT1 contributes to lung cancer pathogenesis. It modulates critical pathways, such as cell proliferation, apoptosis evasion, angiogenesis, and epithelial-mesenchymal transition...
December 7, 2023: Pathology, Research and Practice