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https://www.readbyqxmd.com/read/27904703/lncrna-pvt1-overexpression-is-a-poor-prognostic-biomarker-and-regulates-migration-and-invasion-in-small-cell-lung-cancer
#1
Chengsuo Huang, Shuguang Liu, Huijun Wang, Zicheng Zhang, Qing Yang, Fang Gao
PVT1 has been suggested as playing important roles in diverse biological processes including tumorigenesis. However, the clinical significance and biological function of PVT1 in small cell lung cancer (SCLC) is still unclear. The purpose of this study is to identify the role of PVT1 in SCLC. The expression of PVT1 was examined in SCLC tissues and cell lines through real-time PCR. Meanwhile, the relationship of PVT1 expression levels with clinical characteristics of 120 SCLC patients was analyzed. Univariate and multivariate analyses were performed to determine the association between PVT1 expression and prognosis of SCLC patient...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27833074/the-prognostic-value-of-long-non-coding-rnas-in-non-small-cell-lung-cancer-a-meta-analysis
#2
Manni Wang, Xuelei Ma, Chenjing Zhu, Linghong Guo, Qingfang Li, Ming Liu, Jing Zhang
BACKGROUND: Reports have demonstrated the prognostic function of long non-coding RNAS (lncRNAS) in patients with cancer. However, their prognostic functions in non small cell lung cancer (NSCLC) remain controversial. We therefore performed a meta-analysis on six lncRNAs (PVT1, AFAP1-AS1, LINC01133, ANRIL, MEG3 and UCA1) to clarify their prognostic roles in NSCLC. RESULTS: Thirty-six studies involving 6267 patients with NSCLC and 34 lncRNAs were included. Of the listed lncRNAs, 20 were shown to negatively affect patients' overall survival while the high expression of 13 lncRNAs indicated better survival outcomes...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27827314/lncrnas-as-novel-indicators-of-patients-prognosis-in-stage-i-epithelial-ovarian-cancer-a-retrospective-and-multicentric-study
#3
Paolo Martini, Lara Paracchini, Giulia Caratti, Maurizia Mello-Grand, Robert Fruscio, Luca Beltrame, Enrica Calura, Gabriele Sales, Antonella Ravaggi, Eliana Bignotti, Franco E Odicino, Enrico Sartori, Patrizia Perego, Dionyssios Katsaros, Ilaria Craparotta, Giovanna Chiorino, Stefano Cagnin, Laura Mannarino, Lorenzo Ceppi, Costantino Mangioni, Chiara Ghimenti, Maurizio D'Incalci, Sergio Marchini, Chiara Romualdi
PURPOSE: Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs and is characterized by good prognosis with fewer than 20% of patients relapsing. As it occurs less frequently than advanced stage EOC, its molecular features have not been thoroughly investigated. We have demonstrated that in stage I EOC hsa-miR-200c-3p can predict patients' outcome. In the present study, we analyzed the expression of long non-coding RNAs (lncRNAs) to enable potential definition of a non coding transcriptional signature with prognostic relevance for stage I EOC...
November 8, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27813492/long-non-coding-rna-pvt1-promotes-osteosarcoma-development-by-acting-as-a-molecular-sponge-to-regulate-mir-195
#4
Quan Zhou, Fengli Chen, Jiali Zhao, Baojun Li, Yong Liang, Wei Pan, Shaoxian Zhang, Xinhong Wang, Donghui Zheng
A growing body of evidence has indicated that long non-coding RNAs (lncRNAs) serve as competing endogenous RNAs (ceRNAs) during oncogenesis. In this study, the qRT-PCR results indicated that the lncRNA PVT1 is overexpressed in osteosarcoma and decreased the survival rate of osteosarcoma patients. MTT and clonal colony formation assays were used to detect the effect of PVT1 on proliferation, and flow cytometry was performed to assess apoptosis and the cell cycle. A Transwell assay was used to analyze migration and invasion...
November 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27797003/transcriptome-analysis-of-distinct-long-non-coding-rna-transcriptional-fingerprints-in-lung-adenocarcinoma-and-squamous-cell-carcinoma
#5
Yaqiang Wei, Xiaofei Zhang
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related death, including two major pathologic subtypes, adenocarcinoma (AD) and squamous cell carcinoma (SCC). There are significant differences in the aberrant gene profiling and molecular characteristics among LUAD and LUSC, which lead to the different chemotherapeutic regimens administered to the two NSCLC subtypes. Therefore, unique genetic or epigenetic accurately distinguishing these two subtypes is critical for the diagnosis and treatment of patients...
October 29, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27794184/lncrna-pvt1-regulates-prostate-cancer-cell-growth-by-inducing-the-methylation-of-mir-146a
#6
Hong-Tao Liu, Lei Fang, Yu-Xia Cheng, Qing Sun
Prostate cancer is the third most common causes of death from cancer in men. Our previous study demonstrated that lncRNA PVT1 was overexpressed and played an oncogenic role in the progression of prostate cancer. However, the molecular mechanism of modulating the prostate cancer tumorigenesis was still unknown. In this study, we aim to investigate the interaction between PVT1 and miR-146a in prostate cancer and reveal the potential mechanism in prostate cancer carcinogenesis. The expression level of miR-146a was assessed by quantitative RT-PCR...
October 28, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27775803/long-noncoding-rna-pvt1-as-a-novel-serum-biomarker-for-detection-of-cervical-cancer
#7
J-P Yang, X-J Yang, L Xiao, Y Wang
OBJECTIVE: To investigate long noncoding RNA PVT1 expression in the serum of cervical cancer patients, and to evaluate serum PVT1 level as a diagnostic biomarker for cervical cancer. PATIENTS AND METHODS: Eighty-eight cervical cancer patients, 64 cervical intraepithelial neoplasia patients, 25 breast cancer patients, 25 ovarian cancer patients, and 111 healthy control subjects were enrolled into this study. PVT1 serum level in these participants and PVT1 expression in 20 pairs of cervical cancer tissues and adjacent paired normal tissues was measured by quantitative reverse transcription-polymerase chain reaction...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27774982/genetic-variation-at-the-8q24-21-renal-cancer-susceptibility-locus-affects-hif-binding-to-a-myc-enhancer
#8
Steffen Grampp, James L Platt, Victoria Lauer, Rafik Salama, Franziska Kranz, Viviana K Neumann, Sven Wach, Christine Stöhr, Arndt Hartmann, Kai-Uwe Eckardt, Peter J Ratcliffe, David R Mole, Johannes Schödel
Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel-Lindau tumour suppressor (VHL) and unrestrained activation of hypoxia-inducible transcription factors (HIFs). Genetic and epigenetic determinants have an impact on HIF pathways. A recent genome-wide association study on renal cancer susceptibility identified single-nucleotide polymorphisms (SNPs) in an intergenic region located between the oncogenes MYC and PVT1. Here using assays of chromatin conformation, allele-specific chromatin immunoprecipitation and genome editing, we show that HIF binding to this regulatory element is necessary to trans-activate MYC and PVT1 expression specifically in cells of renal tubular origins...
October 24, 2016: Nature Communications
https://www.readbyqxmd.com/read/27756785/a-positive-feedback-loop-of-lncrna-pvt1-and-foxm1-facilitates-gastric-cancer-growth-and-invasion
#9
Xiang Du, Mi-Die Xu, Yiqin Wang, Wei-Wei Weng, Ping Wei, Peng Qi, Qiongyan Zhang, Cong Tan, Shujuan Ni, Lei Dong, Yusi Yang, Wanrun Lin, Qinghua Xu, Dan Huang, Zhaohui Huang, Yuqing Ma, Wei Zhang, Weiqi Sheng
PURPOSE: The long noncoding RNA (lncRNA) PVT1 is an important epigenetic regulator with a critical role in human tumors. Here, we aimed to investigate the clinical application and the potential molecular mechanisms of PVT1 in gastric cancer (GC) tumorigenesis and progression. EXPERIMENTAL DESIGN: The expression level of PVT1 was determined by RT-qPCR analysis in 190 pairs of GC tissues and adjacent normal gastric mucosa tissues (ANTs). The biological functions of PVT1 were assessed by in vitro and in vivo functional experiments...
October 18, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27723758/common-variants-at-pvt1-atg13-ambra1-ahi1-and-clec16a-are-associated-with-selective-iga-deficiency
#10
Paola G Bronson, Diana Chang, Tushar Bhangale, Michael F Seldin, Ward Ortmann, Ricardo C Ferreira, Elena Urcelay, Luis Fernández Pereira, Javier Martin, Alessandro Plebani, Vassilios Lougaris, Vanda Friman, Tomáš Freiberger, Jiri Litzman, Vojtech Thon, Qiang Pan-Hammarström, Lennart Hammarström, Robert R Graham, Timothy W Behrens
Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Europeans. Our genome-wide association study (GWAS) meta-analysis of 1,635 patients with IgAD and 4,852 controls identified four new significant (P < 5 × 10(-8)) loci and association with a rare IFIH1 variant (p.Ile923Val). Peak new variants (PVT1, P = 4.3 × 10(-11); ATG13-AMBRA1, P = 6.7 × 10(-10); AHI1, P = 8.4 × 10(-10); CLEC16A, P = 1.4 × 10(-9)) overlapped with autoimmune markers (3/4) and correlated with 21 putative regulatory variants, including expression quantitative trait loci (eQTLs) for AHI1 and DEXI and DNase hypersensitivity sites in FOXP3(+) regulatory T cells...
November 2016: Nature Genetics
https://www.readbyqxmd.com/read/27698800/high-expression-of-lncrna-pvt1-promotes-invasion-by-inducing-epithelial-to-mesenchymal-transition-in-esophageal-cancer
#11
Xiangxiang Zheng, Haibo Hu, Shiting Li
The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in numerous diseases, and aberrant lncRNA PVT1 expression has been associated with the development of cancer. However, the underlying mechanism by which lncRNA PVT1 affects cell invasion in esophageal cancer has been not demonstrated. In the current study, the expression of lncRNA PVT1 was found to be increased in esophageal cancer specimens (n=77) by reverse transcription-quantitative polymerase chain reaction, and was correlated with tumor stage (P=0...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27693493/mir-1207-3p-regulates-the-androgen-receptor-in-prostate-cancer-via-fndc1-fibronectin
#12
Dibash K Das, Michelle Naidoo, Adeodat Ilboudo, Jong Y Park, Thahmina Ali, Konstantinos Krampis, Brian D Robinson, Joseph R Osborne, Olorunseun O Ogunwobi
Prostate cancer (PCa) is frequently diagnosed in men, and dysregulation of microRNAs is characteristic of many cancers. MicroRNA-1207-3p is encoded at the non-protein coding gene locus PVT1 on the 8q24 human chromosomal region, an established PCa susceptibility locus. However, the role of microRNA-1207-3p in PCa is unclear. We discovered that microRNA-1207-3p is significantly underexpressed in PCa cell lines in comparison to normal prostate epithelial cells. Increased expression of microRNA-1207-3p in PCa cells significantly inhibits proliferation, migration, and induces apoptosis via direct molecular targeting of FNDC1, a protein which contains a conserved protein domain of fibronectin (FN1)...
November 1, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27596298/differentially-expressed-long-non-coding-rnas-and-the-prognostic-potential-in-colorectal-cancer
#13
Q Li, Y Dai, F Wang, S Hou
Colorectal cancer (CRC) is a disease with high incidence, especially in developed countries. Long non-coding RNAs (lncRNAs) are new research hotspots for their vital roles in regulating gene expression. This study aims to investigate the prognostic value of lncRNAs in CRC patients. A total of 21 cancer-related lncRNAs were detected by PCR array to reveal their expression changes in CRC tissue. A 120-week-long follow-up was performed in 30 CRC patients to analyze the relationship between lncRNA levels and CRC prognosis...
2016: Neoplasma
https://www.readbyqxmd.com/read/27588491/long-non-coding-rna-pvt1-activates-hepatic-stellate-cells-through-competitively-binding-microrna-152
#14
Jianjian Zheng, Fujun Yu, Peihong Dong, Limei Wu, Yuan Zhang, Yanwei Hu, Lei Zheng
Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway is known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported to be involved in a wide range of biological processes. Plasmacytoma variant translocation 1 (PVT1), a novel lncRNA, is often up-regulated in various human cancers. However, the role of PVT1 in liver fibrosis remains undefined. In this study, PVT1 was increased in fibrotic liver tissues and activated HSCs...
August 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27571409/rb1-deficiency-in-triple-negative-breast-cancer-induces-mitochondrial-protein-translation
#15
Robert A Jones, Tyler J Robinson, Jeff C Liu, Mariusz Shrestha, Veronique Voisin, YoungJun Ju, Philip E D Chung, Giovanna Pellecchia, Victoria L Fell, SooIn Bae, Lakshmi Muthuswamy, Alessandro Datti, Sean E Egan, Zhe Jiang, Gustavo Leone, Gary D Bader, Aaron Schimmer, Eldad Zacksenhaus
Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which no specific treatment is currently available. Although the retinoblastoma tumor-suppressor gene (RB1) is frequently lost together with TP53 in TNBC, it is not directly targetable. There is thus great interest in identifying vulnerabilities downstream of RB1 that can be therapeutically exploited. Here, we determined that combined inactivation of murine Rb and p53 in diverse mammary epithelial cells induced claudin-low-like TNBC with Met, Birc2/3-Mmp13-Yap1, and Pvt1-Myc amplifications...
October 3, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27495068/the-long-noncoding-rnas-pvt1-and-uc002mbe-2-in-sera-provide-a-new-supplementary-method-for-hepatocellular-carcinoma-diagnosis
#16
Jinyu Yu, Junqing Han, Jian Zhang, Guanzhen Li, Hui Liu, Xianping Cui, Yantian Xu, Tao Li, Juan Liu, Chuanxi Wang
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver in adults worldwide. Several studies have demonstrated that long noncoding RNAs (lncRNAs) are involved in the development of various types of cancer, including HCC. These findings prompted us to examine the detectability of lncRNAs in blood samples from patients with HCC. In this study, we explored the expression levels of 31 cancer-related lncRNAs in sera from 71 HCC patients and 64 healthy individuals by reverse transcription and quantitative polymerase chain reaction (RT-qPCR)...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27484035/transcriptional-profiling-identifies-the-long-noncoding-rna-plasmacytoma-variant-translocation-pvt1-as-a-novel-regulator-of-the-asthmatic-phenotype-in-human-airway-smooth-muscle
#17
Philip J Austin, Eleni Tsitsiou, Charlotte Boardman, Simon W Jones, Mark A Lindsay, Ian M Adcock, Kian Fan Chung, Mark M Perry
BACKGROUND: The mechanism underlying nonsevere and severe asthma remains unclear, although it is commonly associated with increased airway smooth muscle (ASM) mass. Long noncoding RNAs (lncRNAs) are known to be important in regulating healthy primary airway smooth muscle cells (ASMCs), whereas changed expression has been observed in CD8 T cells from patients with severe asthma. METHODS: Primary ASMCs were isolated from healthy subjects (n = 9) and patients classified as having nonsevere (n = 9) or severe (n = 9) asthma...
July 2, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27366943/a-pan-cancer-analysis-of-myc-pvt1-reveals-cnv-unmediated-deregulation-and-poor-prognosis-in-renal-carcinoma
#18
Ioana Posa, Silvia Carvalho, Joana Tavares, Ana Rita Grosso
The PVT1 lncRNA has recently been involved in tumorigenesis by affecting the protein stability of the MYC proto-oncogene. Both MYC and PVT1 reside in a well-known cancer-risk locus and enhanced levels of their products have been reported in different human cancers. Nonetheless, the extension and relevance of the MYC-PVT1 deregulation in tumorigenesis has not yet been systematically addressed.Here we performed a pan-cancer analysis of matched copy number, transcriptomic, methylation, proteomic and clinicopathological profiles for almost 7000 patients from 17 different cancers represented in the TCGA cohorts...
July 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27283940/long-noncoding-rna-egot-negatively-affects-the-antiviral-response-and-favors-hcv-replication
#19
Elena Carnero, Marina Barriocanal, Celia Prior, Juan Pablo Unfried, Victor Segura, Elizabeth Guruceaga, Mónica Enguita, Cristian Smerdou, Pablo Gastaminza, Puri Fortes
The role of long noncoding RNAs (lncRNAs) in viral infection is poorly studied. We have identified hepatitis C virus (HCV)-Stimulated lncRNAs (CSRs) by transcriptome analysis. Interestingly, two of these CSRs (PVT1 and UCA1) play relevant roles in tumorigenesis, providing a novel link between HCV infection and development of liver tumors. Expression of some CSRs seems induced directly by HCV, while others are upregulated by the antiviral response against the virus. In fact, activation of pathogen sensors induces the expression of CSR32/EGOT RIG-I and the RNA-activated kinase PKR sense HCV RNA, activate NF-κB and upregulate EGOT EGOT is increased in the liver of patients infected with HCV and after infection with influenza or Semliki Forest virus (SFV)...
July 2016: EMBO Reports
https://www.readbyqxmd.com/read/27272214/long-noncoding-rna-pvt1-promotes-cervical-cancer-progression-through-epigenetically-silencing-mir-200b
#20
Shaorong Zhang, Guanli Zhang, Jingying Liu
Long noncoding RNA PVT1 has been reported to be dysregulated and play vital roles in a variety of cancers. However, the functions and molecular mechanisms of PVT1 in cervical cancer remain unclear. The objective of this study was to investigate the expression, clinical significance, biological roles, and underlying functional mechanisms of PVT1 in cervical cancer. Our results revealed that PVT1 is upregulated in cervical cancer tissues. Enhanced expression of PVT1 is associated with larger tumor size, advanced International Federation of Gynecology and Obstetrics stage, and poor prognosis of cervical cancer patients...
August 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
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