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https://www.readbyqxmd.com/read/28534994/amplification-and-the-clinical-significance-of-circulating-cell-free-dna-of-pvt1-in-breast-cancer
#1
Xujing Li, Weijuan Chen, Hui Wang, Qun Wei, Xiaodi Ding, Wentong Li
Duplication in the chromosome 8q24 region is a frequent occurrence in carcinomas. The PVT1 oncogene (PVT1), a long non-coding RNA, is found in this locus. PVT1 amplification is a frequent event in cancers, such as in lymphomas, serous ovarian, colorectal and breast cancers. Ectopic PVT1 expression is related with reduced survival duration in cancer patients. in the present study, we proved that PVT1 is markedly augmented in breast cancer tissues compared with adjacent non-tumorous tissues. Thus, PVT1 is an independent prognostic factor for the survival duration of breast cancer patients...
May 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28520497/lncrna-pvt1-regulates-chondrocyte-apoptosis-in-osteoarthritis-by-acting-as-a-sponge-for-mir-488-3p
#2
Yufei Li, Shuhua Li, Yatong Luo, Yong Liu, Nanhui Yu
Long noncoding RNAs (lncRNAs) have been known to be involved in multiple diverse diseases, including osteoarthritis (OA). The present study aims at exploring the biological role of lncRNA plasmacytoma variant translocation 1 (PVT1) in OA and the underlying mechanism. Results showed that the expression of PVT1 was upregulated in OA chondrocytes compared with normal chondrocytes, silencing PVT1 inhibited the apoptosis of OA chondrocytes, and overexpression of PVT1 promoted the apoptosis of normal chondrocytes...
May 18, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28510638/%C3%AE-asarone-suppresses-the-proliferation-and-migration-of-asmcs-through-targeting-the-lncrna-pvt1-mir-203a-e2f3-signal-pathway-in-rsv-infected-rats
#3
Xiao Yu, Zhe Zhe, Binqing Tang, Shaobin Li, Ling Tang, Yingen Wu, Xiaorong Chen, Hong Fang
Asthma is a chronic inflammatory pulmonary disease and respiratory syncytial virus (RSV) infection is a common cause of lower respiratory tract illness in infants and young children. α-Asarone presents many pharmacological effects and has been demonstrated to be useful in treating asthma. However, the functional mechanism of α-asarone in RSV-infected asthma has not been investigated. Long non-coding RNAs (lncRNAs) have been reported to play critical roles in many biological processes. Although many lncRNAs have been characterized, few were reported in asthma, especially in RSV-induced asthma...
May 16, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28493837/long-non-coding-rnas-may-serve-as-biomarkers-in-breast-cancer-combined-with-primary-lung-cancer
#4
Xianfeng Ding, Yuhan Zhang, Hongjian Yang, Weimin Mao, Bo Chen, Shifeng Yang, Xiaowen Ding, Dehong Zou, Wenju Mo, Xiangming He, Xiping Zhang
Long non-coding RNAs (lncRNAs) have been shown to play important regulatory role in certain type of cancers biology, including breast and lung cancers. However, the lncRNA expression in breast cancer combined with primary lung cancer remains unknown. In this study, databases of the Cancer Genome Atlas (TCGA) and the lncRNA profiler of contained candidate 192 lncRNAs were utilized. 11 lncRNAs were differentially expressed in breast cancer, 9 candidate lncRNAs were differentially expressed in lung cancer. In order to find the aberrant expression of lncRNAs in breast cancer combined with primary lung cancer, seven samples of primary breast cancer and lung cancer were studied for the expression of selected lncRNAs...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409552/long-noncoding-rna-pvt1-promotes-melanoma-progression-via-endogenous-sponging-mir-26b
#5
Bao-Juan Wang, Hong-Wei Ding, Guo-An Ma
Melanoma is an extremely aggressive and high mortality skin malignant tumor, and various long noncoding RNAs (lncRNAs)have been reported to be associated with the oncogenesis of melanoma. The purpose of this study is to investigate the potential roles of lncRNA PVT1 in melanoma progression and to explore the possible mechanisms. A total of 35 patients who were diagnosed as malignant melanoma were enrolled in this study. Expression of PVT1 was significantly up-regulated in melanoma tissue and associated with poor prognosis...
April 12, 2017: Oncology Research
https://www.readbyqxmd.com/read/28404954/upregulation-of-the-long-non-coding-rna-pvt1-promotes-esophageal-squamous-cell-carcinoma-progression-by-acting-as-a-molecular-sponge-of-mir-203-and-lasp1
#6
Pin-Dong Li, Jian-Li Hu, Charlie Ma, Hong Ma, Jing Yao, Li-Li Chen, Jing Chen, Tian-Tian Cheng, Kun-Yu Yang, Gang Wu, Wen-Jie Zhang, Ru-Bo Cao
Long non-coding RNAs are a group of non-coding RNAs longer than 200 nucleotides and possess diverse functions and exhibit exquisite cell-specific and developmental dynamic expression patterns. The role of the long non-coding RNA PVT1 in esophageal squamous cell carcinoma remains unsolved. Here, we showed that PVT1 expression is significantly up-regulated in ESCC tumor samples compared with their normal counterparts. Knockdown of PVT1 suppressed tumor growth in vitro and in vivo. Further studies revealed that silence of PVT1 lead to up-regulation of miR-203, and vice versa...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28391160/long-non-coding-rna-pvt1-promote-lps-induced-septic-acute-kidney-injury-by-regulating-tnf%C3%AE-and-jnk-nf-%C3%AE%C2%BAb-pathways-in-hk-2-cells
#7
Wei Huang, Xiuwen Lan, Xueting Li, Dawei Wang, Yinghao Sun, Qian Wang, Hong Gao, Kaijiang Yu
This study aimed to investigate the effect and underlying mechanism of long non-coding RNA plasmacytoma variant translocation 1 (PVT1) in lipopolysaccharide (LPS)-induced inflammation injury in HK-2 cells. We established LPS-induced septic acute kidney injury (AKI) model in HK-2 cells. LPS-induced HK-2 cells were transfected with pc-PVT1, pc-NC, si-PVT1 or si-NC. Cell viability and apoptosis rate were detected by MTT assay and Annexin V-FITC/PI Apoptosis Detection kit, respectively. The relationships of PVT1 and inflammatory factors were evaluated by RNA Immunoprecipitation (RIP) assay...
April 6, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28381186/the-expression-pattern-of-long-non-coding-rna-pvt1-in-tumor-tissues-and-in-extracellular-vesicles-of-colorectal-cancer-correlates-with-cancer-progression
#8
Kai Guo, Jie Yao, Qiang Yu, Zijian Li, Hu Huang, Jianguo Cheng, Zhigang Wang, Yunfeng Zhu
The plasmacytoma variant translocation 1 gene (PVT1) is a large non-coding locus at adjacent of c-Myc, and long non-coding RNA PVT1 is now recognized as a cancerous gene co-amplified with c-Myc in various cancers. But the expression and functional role of PVT1 in colorectal cancer are still unelucidated. In addition, all the reported long non-coding RNAs so far are discovered in either cells or tissues, but no research about long non-coding RNAs detection in extracellular vesicles has been reported yet. In the present study, we firstly investigated the expression of PVT1 in colorectal cancer specimens and its correlation with the expression of c-Myc and other related genes by real-time polymerase chain reaction...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28355965/long-noncoding-rna-pvt1-promotes-emt-and-cell-proliferation-and-migration-through-downregulating-p21-in-pancreatic-cancer-cells
#9
Bao-Qiang Wu, Yong Jiang, Feng Zhu, Dong-Lin Sun, Xiao-Zhou He
BACKGROUND AND AIM: Long noncoding RNA-plasmacytoma variant translocation 1 is identified to be highly expressed and exhibits oncogenic activity in a variety of human malignancies, including pancreatic cancer. However, little is known about the overall biological role and mechanism of plasmacytoma variant translocation 1 in pancreatic cancer so far. In this study, we investigated the effect of plasmacytoma variant translocation 1 on pancreatic cancer cell proliferation and migration as well as epithelial-mesenchymal transition...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28351322/pvt1-affects-growth-of-glioma-microvascular-endothelial-cells-by-negatively-regulating-mir-186
#10
Yawen Ma, Ping Wang, Yixue Xue, Chengbin Qu, Jian Zheng, Xiaobai Liu, Jun Ma, Yunhui Liu
Vigorous angiogenesis is one of the reasons for the poor prognosis of glioma. A number of studies have shown that long non-coding RNA can affect a variety of biological behaviors of tumors. However, the influence of long non-coding RNAs on glioma vascular endothelial cells remains unclear. To simulate the glioma microenvironment, we applied glioma-conditioned medium to human cerebral microvascular endothelial cells. The long non-coding RNA PVT1 was found to be highly expressed in glioma vascular endothelial cells...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28296507/lncrna-pvt1-epigenetically-silences-mir-195-and-modulates-emt-and-chemoresistance-in-cervical-cancer-cells
#11
Ching-Ju Shen, Ya-Min Cheng, Chiu-Lin Wang
The plasmacytoma variant translocation 1 gene (PVT1) is an oncogenic lncRNA with regulative effect on chemosensitivity in cervical cancer. However, the underlying mechanisms were not fully understood. In this study, HPV16 positive CaSki and SiHa cells were used as in-vitro cell model. Knockdown of HPV16 E7 significantly inhibited PVT1 and restored miR-195 expression. PVT1 directly interacts with EZH2 and the complex anchors in the promoter region of miR-195. PVT1 overexpression resulted in increased H3K27me3 levels in the miR-195 promoter region, while PVT1 knockdown decreased H3K27me3 levels in the promoter region...
March 15, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28276314/long-non-coding-rna-pvt1-facilitates-cervical-cancer-progression-via-negative-regulating-of-mir-424
#12
Ya-Li Gao, Zi-Shen Zhao, Ming-Yun Zhang, Li-Jie Han, Yu-Jin Dong, Bo Xu
Emerging evidence suggests that the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) is involved in pathogenesis of cervical cancer. However, the potential mechanism is rarely reported. Our study found that PVT1 was up-regulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration and invasion of cervical cancer cells were markedly decreased. MiRNA expression profiles demonstrate that miR-424 was markedly down-regulated in cervical cancer tissue...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28265576/long-noncoding-rna-pvt1-as-a-novel-diagnostic-biomarker-and-therapeutic-target-for-melanoma
#13
Xiangjun Chen, Guozhen Gao, Sha Liu, Li Yu, Dexiong Yan, Xingwei Yao, Weijing Sun, Dezhi Han, Hao Dong
Accumulating evidences indicated that plasmacytoma variant translocation 1 (PVT1) plays vital roles in several cancers. However, the expression, functions, and clinical values of PVT1 in melanoma are still unknown. In this study we measured the expression of PVT1 in clinical tissues and serum samples and explored the diagnostic value of PVT1 for melanoma and the effects of PVT1 on melanoma cell proliferation, cell cycle, and migration. Our results, combined with publicly available PVT1 expression data, revealed that PVT1 is upregulated in melanoma tissues compared with nonneoplastic nevi tissues...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28258379/long-noncoding-rna-pvt1-acts-as-a-sponge-to-inhibit-microrna-152-in-gastric-cancer-cells
#14
Ting Li, Xiang-Ling Meng, Wen-Qi Yang
BACKGROUND: PVT1 was up-regulated in patients with gastric cancer (GC) and might be as a novel biomarker for predicting GC. However, the exact mechanism of PVT1 exerting functions in GC was still poorly understood. Emerging evidence suggests that long noncoding RNAs may act as endogenous microRNA (miRNA) sponges to bind to miRNAs and regulate their function. AIM: This study aimed to determine the function of PVT1 on miR-152 expression in GC cells. METHODS: The levels of PVT1 and miR-152 were determined in GC tissues by quantitative real-time PCR...
March 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28251177/a-novel-microrna-1207-3p-fndc1-fn1-ar-regulatory-pathway-in-prostate-cancer
#15
Dibash K Das, Olorunseun O Ogunwobi
Prostate cancer (PCa) is the second most common cause of cancer-specific deaths in the U.S. Unfortunately, the underlying molecular mechanisms for its development and progression remain unclear. Studies have established that microRNAs (miRNAs) are dysregulated in PCa. The intron-derived microRNA-1207-3p (miR-1207-3p) is encoded at the non-protein coding gene locus PVT1 on the 8q24 human chromosomal region, an established PCa susceptibility locus. However, miR-1207-3p in PCa had not previously been investigated...
2017: RNA & Disease
https://www.readbyqxmd.com/read/28187158/role-of-the-long-non-coding-rna-pvt1-in-the-dysregulation-of-the-cerna-cerna-network-in-human-breast-cancer
#16
Federica Conte, Giulia Fiscon, Matteo Chiara, Teresa Colombo, Lorenzo Farina, Paola Paci
Recent findings have identified competing endogenous RNAs (ceRNAs) as the drivers in many disease conditions, including cancers. The ceRNAs indirectly regulate each other by reducing the amount of microRNAs (miRNAs) available to target messenger RNAs (mRNAs). The ceRNA interactions mediated by miRNAs are modulated by a titration mechanism, i.e. large changes in the ceRNA expression levels either overcome, or relieve, the miRNA repression on competing RNAs; similarly, a very large miRNA overexpression may abolish competition...
2017: PloS One
https://www.readbyqxmd.com/read/28123544/molecular-heterogeneity-in-the-novel-fusion-gene-apip-fgfr2-diversity-of-genomic-breakpoints-in-gastric-cancer-with-high-level-amplifications-at-11p13-and-10q26
#17
Takashi Okuda, Tomohiko Taki, Kazuhiro Nishida, Yoshiaki Chinen, Hisao Nagoshi, Chouhei Sakakura, Masafumi Taniwaki
Several novel fusion transcripts were identified by next-generation sequencing in gastric cancer; however, the breakpoint junctions have yet to be characterized. The present study characterized a plethora of APIP-FGFR2 genomic breakpoints in the SNU-16 gastric cancer cell line, which harbored homogeneously staining regions (hsrs) and double minute chromosomes. Oligonucleotide microarrays revealed high-level amplifications at chromosomes 8q24.1 (0.8 Mb region), 10q26 (1.1 Mb) and 11p13 (1.1 Mb). These amplicons contained MYC and PVT1 at chromosome 8q24...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28122299/the-long-noncoding-rna-pvt1-functions-as-a-competing-endogenous-rna-by-sponging-mir-186-in-gastric-cancer
#18
Tao Huang, Hong Wei Liu, Jia Qi Chen, Shou Han Wang, Li Qun Hao, Miao Liu, Bin Wang
BACKGROUND: Recent evidence has highlighted the key regulatory roles of long non-coding RNAs (lncRNAs) in tumor development and progression including gastric cancer (GC).The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in some tumors. However, the potential biological roles and regulatory mechanisms of PVT1 involved in GC remained poorly understood. METHODS: Quantitative real-time PCR (QRT-PCR) was used to determine the expression of PVT1 and miR-186 in GC tissues...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27986464/circular-rna-profile-identifies-circpvt1-as-a-proliferative-factor-and-prognostic-marker-in-gastric-cancer
#19
Jie Chen, Yan Li, Qiupeng Zheng, Chunyang Bao, Jian He, Bin Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi, Shenglin Huang
Circular RNAs (circRNAs) comprise a novel class of widespread non-coding RNAs that may regulate gene expression in eukaryotes. However, the characterization and function of circRNAs in human cancer remain elusive. Here we identified at least 5500 distinct circRNA candidates and a series of circRNAs that are differentially expressed in gastric cancer (GC) tissues compared with matched normal tissues. We further characterized one circRNA derived from the PVT1 gene and termed it as circPVT1. The expression of circPVT1 is often upregulated in GC tissues due to the amplification of its genomic locus...
March 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27966444/construction-of-differential-mrna-lncrna-crosstalk-networks-based-on-cerna-hypothesis-uncover-key-roles-of-lncrnas-implicated-in-esophageal-squamous-cell-carcinoma
#20
Shuang Yang, Qianqian Ning, Guobin Zhang, Hong Sun, Zhen Wang, Yixue Li
Increasing evidence has indicated that lncRNAs acting as competing endogenous RNAs (ceRNAs) play crucial roles in tumorigenesis, metastasis and diagnosis of cancer. However, the function of lncRNAs as ceRNAs involved in esophageal squamous cell carcinoma (ESCC) is still largely unknown. In this study, clinical implications of two intrinsic subtypes of ESCC were identified based on expression profiles of lncRNA and mRNA. ESCC subtype-specific differential co-expression networks between mRNAs and lncRNAs were constructed to reveal dynamic changes of their crosstalks mediated by miRNAs during tumorigenesis...
December 27, 2016: Oncotarget
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