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https://www.readbyqxmd.com/read/29351317/hafts-are-novel-lncrna-transcripts-from-aflatoxin-exposure
#1
B Alex Merrick, Justin S Chang, Dhiral P Phadke, Meredith A Bostrom, Ruchir R Shah, Xinguo Wang, Oksana Gordon, Garron M Wright
The transcriptome can reveal insights into precancer biology. We recently conducted RNA-Seq analysis on liver RNA from male rats exposed to the carcinogen, aflatoxin B1 (AFB1), for 90 days prior to liver tumor onset. Among >1,000 differentially expressed transcripts, several novel, unannotated Cufflinks-assembled transcripts, or HAfTs (Hepatic Aflatoxin Transcripts) were found. We hypothesized PCR-cloning and RACE (rapid amplification of cDNA ends) could further HAfT identification. Sanger data was obtained for 6 transcripts by PCR and 16 transcripts by 5'- and 3'-RACE...
2018: PloS One
https://www.readbyqxmd.com/read/29348896/prognostic-value-of-long-non-coding-rna-pvt1-as-a-novel-biomarker-in-various-cancers-a-meta-analysis
#2
Shikai Zhu, Ping Shuai, Chong Yang, Yun Zhang, Shan Zhong, Xingchao Liu, Kai Chen, Qin Ran, Hongji Yang, Yu Zhou
Background: Plasmacytoma variant translocation 1 (PVT1) has recently been reported to be aberrantly expressed and serves as a prognostic biomarker in many types of cancers. However, its prognostic significance remains controversial. Here, we conducted a meta-analysis to investigate the prognostic value of PVT1 expression in cancers. Results: A total of 2109 patients from 20 studies were included. The results showed that elevated PVT1 expression predicted a poor outcome for overall survival (OS) in nine types of cancers (HR = 1...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310950/expression-and-clinical-role-of-long-non-coding-rna-in-high-grade-serous-carcinoma
#3
Natalie Filippov-Levy, Hallel Cohen-Schussheim, Claes G Tropé, Thea E Hetland Falkenthal, Yoav Smith, Ben Davidson, Reuven Reich
OBJECTIVE: To profile long non-coding RNA (lncRNA) expression at the various anatomic sites of high-grades serous carcinoma (HGSC) and in effusion-derived exosomes. METHODS: LncRNA profiling was performed on 60 HGSC specimens, including 10 ovarian tumors, 10 solid metastases and 10 malignant effusions, as well as exosomes from 30 effusion supernatants. Anatomic site-related expression of ESRG, Link-A, GAS5, MEG3, GATS, PVT1 H19, Linc-RoR, HOTAIR and MALAT1 was validated by quantitative PCR and assessed for clinical relevance in a series of 77 HGSC effusions, 40 ovarian carcinomas, 21 solid metastases and 42 supernatant exosomes...
January 5, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29286144/effect-of-long-non-coding-rna-pvt1-on-cell-proliferation-and-migration-in-melanoma
#4
Lamei Chen, Dongmei Ma, Yuanyuan Li, Xiaoying Li, Lei Zhao, Jing Zhang, Yali Song
The present study aimed to investigate the potential role of the long non‑coding RNA (lncRNA) Pvt1 oncogene (non‑protein coding) (PVT1) in the progression and metastasis of malignant melanoma, and to reveal its possible molecular mechanisms. The expression of lncRNA PVT1 in melanoma tissues and adjacent normal skin from patients with melanoma, and in the melanoma A‑375 and sk‑mel‑5 cell lines, was analyzed using reverse transcription‑quantitative polymerase chain reaction and western blot analyses...
December 20, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29280051/long-non-coding-rna-linc-ror-is-upregulated-in-papillary-thyroid-carcinoma
#5
Ranran Zhang, Heather Hardin, Wei Huang, Darya Buehler, Ricardo V Lloyd
Long non-coding RNAs (lncRNAs) may contribute to carcinogenesis and tumor progression by regulating transcription and gene expression. The role of lncRNAs in the regulation of thyroid cancer progression is being extensively examined. Here, we analyzed three lncRNAs that were overexpressed in papillary thyroid carcinomas, long intergenic non-protein coding RNA, regulator of reprogramming (Linc-ROR, ROR) PVT1 oncogene (PVT1), and HOX transcript antisense intergenic RNA (HOTAIR) to determine their roles in thyroid tumor development and progression...
December 26, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/29277611/long-non-coding-rna-pvt1-5-promotes-cell-proliferation-by-regulating-mir-126-slc7a5-axis-in-lung-cancer
#6
Hongliang Li, Shuxian Chen, Jia Liu, Xiaopeng Guo, Xudong Xiang, Tianqi Dong, Pengzhan Ran, Qian Li, Bei Zhu, Xiyu Zhang, Dan Wang, Chunjie Xiao, Shangyong Zheng
Dysregulated long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play key roles in the development of human cancers. The lncRNA plasmacytoma variant translocation 1 (PVT1) is reported to be an oncogene in a variety of cancers. However, the roles of PVT1-5 and its related miRNAs in lung cancer are poorly understood. In this study, we found that PVT1-5 expression was significantly increased in lung cancer tissues and cell lines. By using biotin-labeled lncRNA-PVT1-5 probe for miRNA in vivo precipitation (miRIP) in lung cancer cells and dual-luciferase reporterassays, we identified that miR-126 was associated with lncRNA-PVT1-5...
December 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29244840/high-expression-of-lncrna-pvt1-independently-predicts-poor-overall-survival-in-patients-with-primary-uveal-melanoma
#7
Haiming Xu, Jingwen Gong, Hui Liu
The plasmacytoma variant translocation 1 gene (PVT1) plays an oncogenic role in the initiation and progression of multiple cancers. In this study, by using deep-sequencing data and follow-up data in the Cancer Genome Atlas-Uveal melanomas (TCGA-UVM), we assessed the association between the expression of PVT1 and clinicopathological characteristics of patients with uveal melanoma, the mechanism of its dysregulation and its prognostic value. Results showed that high PVT1 expression group had a higher proportion of epithelioid cell dominant disease (a more malignant histological subtype than spindle cell dominant disease) and more cases of extrascleral extension (a risk factor for metastasis) compared with the low PVT1 expression group...
2017: PloS One
https://www.readbyqxmd.com/read/29242407/central-role-of-the-p53-pathway-in-the-noncoding-rna-response-to-oxidative-stress
#8
Paola Fuschi, Matteo Carrara, Christine Voellenkle, Jose Manuel Garcia-Manteiga, Paolo Righini, Biagina Maimone, Elena Sangalli, Francesco Villa, Claudia Specchia, Mario Picozza, Giovanni Nano, Carlo Gaetano, Gaia Spinetti, Annibale A Puca, Alessandra Magenta, Fabio Martelli
Oxidative stress plays a fundamental role in many conditions. Specifically, redox imbalance inhibits endothelial cell (EC) growth, inducing cell death and senescence. We used global transcriptome profiling to investigate the involvement of noncoding-RNAs in these phenotypes. By RNA-sequencing, transcriptome changes were analyzed in human ECs exposed to H2O2, highlighting a pivotal role of p53-signaling. Bioinformatic analysis and validation in p53-silenced ECs, identified several p53-targets among both mRNAs and long noncoding-RNAs (lncRNAs), including MALAT1 and NEAT1...
December 12, 2017: Aging
https://www.readbyqxmd.com/read/29221115/lncrna-malat1-hottip-and-pvt1-as-predictors-for-predicting-the-efficacy-of-gem-based-chemotherapy-in-first-line-treatment-of-pancreatic-cancer-patients
#9
Cui-Juan Wang, Sheng-Bin Shi, Jing Tian, Jun Xu, Zuo-Xing Niu
This study evaluated the lnc-RNAs as biomarker to predict efficacy of gemcitabine (GEM) based chemotherapy as the first-line treatment for locally advanced or advanced pancreatic cancer patients. We selected 62 patients with GEM based chemotherapy and divided two groups according to the PFS. We found that the expression of MALAT1, HOTTIP, and PVT1 in serum had a significant difference among the two groups. Furthermore, we estimated the PFS and response rate based on the expression levels of MALAT1, HOTTIP and PVT1...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29193797/the-long-non-coding-rna-pvt1-represses-angptl4-transcription-through-binding-with-ezh2-in-trophoblast-cell
#10
Yetao Xu, Yifan Lian, Yuanyuan Zhang, Shiyun Huang, Qing Zuo, Nana Yang, Yanzi Chen, Dan Wu, Lizhou Sun
Despite progress in diagnostics and treatment for preeclampsia, it remains the foremost cause of maternal and foetal perinatal morbidity and mortality worldwide. Over recent years, various lines of evidence have emphasized long non-coding RNAs (lncRNAs) which function as an innovative regulator of biological behaviour, as exemplified by proliferation, apoptosis and metastasis. However, the role of lncRNAs has not been well described in preeclampsia. Here, we identified a lncRNA, PVT1, whose expression was down-regulated in qRT-PCR analyses in severe preeclampsia...
November 29, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29180669/myc-containing-amplicons-in-acute-myeloid-leukemia-genomic-structures-evolution-and-transcriptional-consequences
#11
A ĹAbbate, D Tolomeo, I Cifola, M Severgnini, A Turchiano, B Augello, G Squeo, P D Addabbo, D Traversa, G Daniele, A Lonoce, M Pafundi, M Carella, O Palumbo, A Dolnik, D Muehlematter, J Schoumans, N Van Roy, G De Bellis, G Martinelli, G Merla, L Bullinger, C Haferlach, C T Storlazzi
Double minutes (dmin), homogeneously staining regions, and ring chromosomes are vehicles of gene amplification in cancer. The underlying mechanism leading to their formation as well as their structure and function in acute myeloid leukemia (AML) remain mysterious. We combined a range of high-resolution genomic methods to investigate the architecture and expression pattern of amplicons involving chromosome band 8q24 in 23 cases of AML (AML-amp). This revealed that different MYC-dmin architectures can coexist within the same leukemic cell population, indicating a step-wise evolution rather than a single event origin, such as through chromothripsis...
November 28, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29156724/lncrna-pvt1-and-its-splicing-variant-function-as-competing-endogenous-rna-to-regulate-clear-cell-renal-cell-carcinoma-progression
#12
Tao Yang, Hui Zhou, Peijun Liu, Libin Yan, Weimin Yao, Ke Chen, Jin Zeng, Heng Li, Junhui Hu, Hua Xu, Zhangqun Ye
Long non-coding RNAs (lncRNAs) exert critical regulatory roles in the development and progression of several cancers. Plasmacytoma variant translocation 1 (PVT1), an lncRNA, was shown to be upregulated in clear cell renal cell carcinoma (ccRCC) in our study, while Kaplan-Meier curve and Cox regression analysis showed that high expression of PVT1 was associated with poor overall survival (OS) and disease free survival (DFS) in ccRCC patients. In vitro experiments revealed that PVT1 promoted renal cancer cell proliferation, migration, and invasion, while in vivo studies confirmed its oncogenic roles in ccRCC...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152119/a-genome-wide-comprehensively-analyses-of-long-noncoding-rna-profiling-and-metastasis-associated-lncrnas-in-renal-cell-carcinoma
#13
Xue Xu, Yongcan Xu, Chuanqin Shi, Baoyu Wang, Xiang Yu, Yanfen Zou, Tao Hu
Recently, a growing number of studies have indicated that long noncoding RNAs (lncRNAs) are emerging as new critical regulators of tumorigenesis and prognostic markers in multiple cancers. However, the expression pattern of lncRNAs and their contributions in renal cell carcinoma (RCC) remains poorly understood. In this study, we performed a genome-wide comprehensively analysis of lncRNAs profiling and clinical relevance to provide valuable lncRNA candidates for the further study in RCC. RCC and non-tumor tissues RNA sequencing data, and microarray data were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), then, these data were annotated and analyzed to find dysregulated lncRNAs in RCC...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146581/long-noncoding-rnas-emerging-players-in-thyroid-cancer-pathogenesis
#14
Avaniyapuram Kannan Murugan, Munirajan Arasambattu Kannan, Ali S Alzahrani
Thyroid cancer continues to be the most common malignancy of endocrine glands. The incidence of thyroid cancer rises significantly over the past 4 decades and emerges as a major health issue. In recent years, a significant progress has been achieved in our understanding of molecular mechanisms of thyroid carcinogenesis, resulting in significant diagnostic, prognostic and therapeutic implications; yet, it has not reached a satisfactory level. Identifying novel molecular therapeutic targets and molecules for diagnosis and prognosis are expected to advance the overall management of this common malignancy...
November 16, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29133127/knockdown-of-lncrna-pvt1-inhibits-tumorigenesis-in-non-small-cell-lung-cancer-by-regulating-mir-497-expression
#15
Dong Guo, Yanli Wang, Kewei Ren, Xinwei Han
Plasmacytoma variant translocation1 (PVT1) was reported to be upregulated in non-small-cell lung cancer (NSCLC) tissues, serve as a promising biomarker for diagnosis and prognosis of NSCLC, and promoted NSCLC cell proliferation. However, the detailed molecular mechanism of PVT1 involved in the pathogenesis and development of NSCLC remains largely unknown. In this study, the expression levels of PVT1 and miR-497 in NSCLC cells were determined by qRT-PCR. Cell viability, invasion and apoptosis were detected by MTT assay, cell invasion assay and flow cytometry analysis, respectively...
November 10, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29115513/lncrna-pvt1-regulate-expression-of-hif1%C3%AE-via-functioning-as-cerna-for-mir%C3%A2-199a%C3%A2-5p-in-non%C3%A2-small-cell-lung-cancer-under-hypoxia
#16
Chunhong Wang, Chunfang Han, Yibo Zhang, Fengqin Liu
Non‑small cell lung cancer (NSCLC) represents one of the most important causes of cancer mortality in the world, and leads to the largest number of deaths in all kinds of lung cancer. Hypoxia has been confirmed to be a characteristic feature of NSCLC and has been shown to decrease the therapeutic efficacy of radiotherapy and some forms of chemotherapy. Previous studies revealed that many miRNAs have been proven to be involved in the molecular regulation of hypoxia and to affect the protein expression level of HIF‑1α...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29108287/prognostic-and-diagnostic-significance-of-lncrnas-expression-in-cervical-cancer-a-systematic-review-and-meta-analysis
#17
Shuqi Chi, Lina Shen, Teng Hua, Shuangge Liu, Guobing Zhuang, Xiaoxiao Wang, Xing Zhou, Guozhen Wang, Hongbo Wang
Long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in cervical cancer (CC) and presumably serve as diagnostic or prognostic markers. We thus performed a systematic review and meta-analysis to evaluate the clinical values of dysregulated lncRNAs in CC. A literature search was performed using the electronic databases PubMed, Embase, and Web of Science. A total of 22 relevant studies were eligible, including 21 on clinicopathological features, 18 on prognosis, and 4 on diagnosis. For clinicopathological features, HOTAIR expression was positively associated with tumor size (odds ratio [OR]=2...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108264/lncrnas-pvt1-and-har1a-are-prognosis-biomarkers-and-indicate-therapy-outcome-for-diffuse-glioma-patients
#18
Hecun Zou, Lan-Xiang Wu, Yonglong Yang, Shuang Li, Ying Mei, Yong-Bin Liu, Lihua Zhang, Yu Cheng, Hong-Hao Zhou
Diffuse gliomas are well known malignant brain tumors. Long non-coding RNAs (lncRNAs), a type of RNA transcript with more than 200 nucleotides, involve in tumorigenesis and development of various cancers. This study focused on identifying differentially expressed lncRNAs in gliomas based on gene expression profiling, and chose certain lncRNAs PVT1, CYTOR, HAR1A and MIAT, which changed with significant differences. Further analysis of TCGA and GEO data revealed that the expressions of PVT1 and CYTOR were up-regulated, while HAR1A and MIAT expressions were down-regulated in gliomas...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29095108/pharmacogenetics-of-glatiramer-acetate-therapy-for-multiple-sclerosis-the-impact-of-genome-wide-association-studies-identified-disease-risk-loci
#19
Olga Kulakova, Vitalina Bashinskaya, Ivan Kiselev, Natalia Baulina, Ekaterina Tsareva, Ruslan Nikolaev, Maxim Kozin, Sergey Shchur, Alexander Favorov, Alexey Boyko, Olga Favorova
AIM: Association analysis of genome-wide association studies (GWAS) identified multiple sclerosis (MS) risk genetic variants with glatiramer acetate (GA) treatment efficacy. PATIENTS & METHODS: SNPs in 17 GWAS-identified immune response loci were analyzed in 296 Russian MS patients as possible markers of optimal GA treatment response for at least 2 years. RESULTS: Alleles/genotypes of EOMES, CLEC16A, IL22RA2, PVT1 and HLA-DRB1 were associated by themselves with event-free phenotype during GA treatment for at least 2 years (p f  = 0...
November 2, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/29081406/upregulation-of-long-noncoding-rna-pvt1-predicts-unfavorable-prognosis-in-patients-with-clear-cell-renal-cell-carcinoma
#20
Xu Bao, Junyao Duan, Yongji Yan, Xin Ma, Yu Zhang, Hanfeng Wang, Dong Ni, Shengpan Wu, Cheng Peng, Yang Fan, Yu Gao, Xintao Li, Jianwen Chen, Qingshan Du, Fan Zhang, Xu Zhang
BACKGROUND: Renal cell carcinoma (RCC) is one of the most malignant genitourinary diseases worldwide. Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs in the human genome that are involved in RCC initiation and progression. OBJECTIVE: To investigate the expression of PVT1 in ccRCC and evaluate its correlation with clinicopathologic characteristics and patients' survival. METHODS: Quantitative real-time PCR was performed to examine PVT1 expression in 129 ccRCC tissue samples and matched adjacent normal tissue samples...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
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