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https://www.readbyqxmd.com/read/28296507/lncrna-pvt1-epigenetically-silences-mir-195-and-modulates-emt-and-chemoresistance-in-cervical-cancer-cells
#1
Ching-Ju Shen, Ya-Min Cheng, Chiu-Lin Wang
The plasmacytoma variant translocation 1 gene (PVT1) is an oncogenic lncRNA with regulative effect on chemosensitivity in cervical cancer. However, the underlying mechanisms were not fully understood. In this study, HPV16 positive CaSki and SiHa cells were used as in-vitro cell model. Knockdown of HPV16 E7 significantly inhibited PVT1 and restored miR-195 expression. PVT1 directly interacts with EZH2 and the complex anchors in the promoter region of miR-195. PVT1 overexpression resulted in increased H3K27me3 levels in the miR-195 promoter region, while PVT1 knockdown decreased H3K27me3 levels in the promoter region...
March 15, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28276314/long-non-coding-rna-pvt1-facilitates-cervical-cancer-progression-via-negative-regulating-of-mir-424
#2
Ya-Li Gao, Zi-Shen Zhao, Ming-Yun Zhang, Li-Jie Han, Yu-Jin Dong, Bo Xu
Emerging evidence suggests that the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) is involved in pathogenesis of cervical cancer. However, the potential mechanism is rarely reported. Our study found that PVT1 was up-regulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration and invasion of cervical cancer cells were markedly decreased. MiRNA expression profiles demonstrate that miR-424 was markedly down-regulated in cervical cancer tissue...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28265576/long-noncoding-rna-pvt1-as-a-novel-diagnostic-biomarker-and-therapeutic-target-for-melanoma
#3
Xiangjun Chen, Guozhen Gao, Sha Liu, Li Yu, Dexiong Yan, Xingwei Yao, Weijing Sun, Dezhi Han, Hao Dong
Accumulating evidences indicated that plasmacytoma variant translocation 1 (PVT1) plays vital roles in several cancers. However, the expression, functions, and clinical values of PVT1 in melanoma are still unknown. In this study we measured the expression of PVT1 in clinical tissues and serum samples and explored the diagnostic value of PVT1 for melanoma and the effects of PVT1 on melanoma cell proliferation, cell cycle, and migration. Our results, combined with publicly available PVT1 expression data, revealed that PVT1 is upregulated in melanoma tissues compared with nonneoplastic nevi tissues...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28258379/long-noncoding-rna-pvt1-acts-as-a-sponge-to-inhibit-microrna-152-in-gastric-cancer-cells
#4
Ting Li, Xiang-Ling Meng, Wen-Qi Yang
BACKGROUND: PVT1 was up-regulated in patients with gastric cancer (GC) and might be as a novel biomarker for predicting GC. However, the exact mechanism of PVT1 exerting functions in GC was still poorly understood. Emerging evidence suggests that long noncoding RNAs may act as endogenous microRNA (miRNA) sponges to bind to miRNAs and regulate their function. AIM: This study aimed to determine the function of PVT1 on miR-152 expression in GC cells. METHODS: The levels of PVT1 and miR-152 were determined in GC tissues by quantitative real-time PCR...
March 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28251177/a-novel-microrna-1207-3p-fndc1-fn1-ar-regulatory-pathway-in-prostate-cancer
#5
Dibash K Das, Olorunseun O Ogunwobi
Prostate cancer (PCa) is the second most common cause of cancer-specific deaths in the U.S. Unfortunately, the underlying molecular mechanisms for its development and progression remain unclear. Studies have established that microRNAs (miRNAs) are dysregulated in PCa. The intron-derived microRNA-1207-3p (miR-1207-3p) is encoded at the non-protein coding gene locus PVT1 on the 8q24 human chromosomal region, an established PCa susceptibility locus. However, miR-1207-3p in PCa had not previously been investigated...
2017: RNA & Disease
https://www.readbyqxmd.com/read/28187158/role-of-the-long-non-coding-rna-pvt1-in-the-dysregulation-of-the-cerna-cerna-network-in-human-breast-cancer
#6
Federica Conte, Giulia Fiscon, Matteo Chiara, Teresa Colombo, Lorenzo Farina, Paola Paci
Recent findings have identified competing endogenous RNAs (ceRNAs) as the drivers in many disease conditions, including cancers. The ceRNAs indirectly regulate each other by reducing the amount of microRNAs (miRNAs) available to target messenger RNAs (mRNAs). The ceRNA interactions mediated by miRNAs are modulated by a titration mechanism, i.e. large changes in the ceRNA expression levels either overcome, or relieve, the miRNA repression on competing RNAs; similarly, a very large miRNA overexpression may abolish competition...
2017: PloS One
https://www.readbyqxmd.com/read/28123544/molecular-heterogeneity-in-the-novel-fusion-gene-apip-fgfr2-diversity-of-genomic-breakpoints-in-gastric-cancer-with-high-level-amplifications-at-11p13-and-10q26
#7
Takashi Okuda, Tomohiko Taki, Kazuhiro Nishida, Yoshiaki Chinen, Hisao Nagoshi, Chouhei Sakakura, Masafumi Taniwaki
Several novel fusion transcripts were identified by next-generation sequencing in gastric cancer; however, the breakpoint junctions have yet to be characterized. The present study characterized a plethora of APIP-FGFR2 genomic breakpoints in the SNU-16 gastric cancer cell line, which harbored homogeneously staining regions (hsrs) and double minute chromosomes. Oligonucleotide microarrays revealed high-level amplifications at chromosomes 8q24.1 (0.8 Mb region), 10q26 (1.1 Mb) and 11p13 (1.1 Mb). These amplicons contained MYC and PVT1 at chromosome 8q24...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28122299/the-long-noncoding-rna-pvt1-functions-as-a-competing-endogenous-rna-by-sponging-mir-186-in-gastric-cancer
#8
Tao Huang, Hong Wei Liu, Jia Qi Chen, Shou Han Wang, Li Qun Hao, Miao Liu, Bin Wang
BACKGROUND: Recent evidence has highlighted the key regulatory roles of long non-coding RNAs (lncRNAs) in tumor development and progression including gastric cancer (GC).The long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been identified as an oncogene in some tumors. However, the potential biological roles and regulatory mechanisms of PVT1 involved in GC remained poorly understood. METHODS: Quantitative real-time PCR (QRT-PCR) was used to determine the expression of PVT1 and miR-186 in GC tissues...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27986464/circular-rna-profile-identifies-circpvt1-as-a-proliferative-factor-and-prognostic-marker-in-gastric-cancer
#9
Jie Chen, Yan Li, Qiupeng Zheng, Chunyang Bao, Jian He, Bin Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi, Shenglin Huang
Circular RNAs (circRNAs) comprise a novel class of widespread non-coding RNAs that may regulate gene expression in eukaryotes. However, the characterization and function of circRNAs in human cancer remain elusive. Here we identified at least 5500 distinct circRNA candidates and a series of circRNAs that are differentially expressed in gastric cancer (GC) tissues compared with matched normal tissues. We further characterized one circRNA derived from the PVT1 gene and termed it as circPVT1. The expression of circPVT1 is often upregulated in GC tissues due to the amplification of its genomic locus...
March 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27966444/construction-of-differential-mrna-lncrna-crosstalk-networks-based-on-cerna-hypothesis-uncover-key-roles-of-lncrnas-implicated-in-esophageal-squamous-cell-carcinoma
#10
Shuang Yang, Qianqian Ning, Guobin Zhang, Hong Sun, Zhen Wang, Yixue Li
Increasing evidence has indicated that lncRNAs acting as competing endogenous RNAs (ceRNAs) play crucial roles in tumorigenesis, metastasis and diagnosis of cancer. However, the function of lncRNAs as ceRNAs involved in esophageal squamous cell carcinoma (ESCC) is still largely unknown. In this study, clinical implications of two intrinsic subtypes of ESCC were identified based on expression profiles of lncRNA and mRNA. ESCC subtype-specific differential co-expression networks between mRNAs and lncRNAs were constructed to reveal dynamic changes of their crosstalks mediated by miRNAs during tumorigenesis...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27936176/correction-role-of-microrna-1207-5p-and-its-host-gene-the-long-non-coding-rna-pvt1-as-mediators-of-extracellular-matrix-accumulation-in-the-kidney-implications-for-diabetic-nephropathy
#11
M Lucrecia Alvarez, Mahdieh Khosroheidari, Elena Eddy, Jeff Kiefer, Johanna K DiStefano
[This corrects the article DOI: 10.1371/journal.pone.0077468.].
2016: PloS One
https://www.readbyqxmd.com/read/27928058/identification-of-senescence-associated-circular-rnas-sac-rnas-reveals-senescence-suppressor-circpvt1
#12
Amaresh C Panda, Ioannis Grammatikakis, Kyoung Mi Kim, Supriyo De, Jennifer L Martindale, Rachel Munk, Xiaoling Yang, Kotb Abdelmohsen, Myriam Gorospe
Using RNA sequencing (RNA-Seq), we compared the expression patterns of circular RNAs in proliferating (early-passage) and senescent (late-passage) human diploid WI-38 fibroblasts. Among the differentially expressed senescence-associated circRNAs (which we termed 'SAC-RNAs'), we identified CircPVT1, generated by circularization of an exon of the PVT1 gene, as a circular RNA showing markedly reduced levels in senescent fibroblasts. Reducing CircPVT1 levels in proliferating fibroblasts triggered senescence, as determined by a rise in senescence-associated β-galactosidase activity, higher abundance of CDKN1A/P21 and TP53, and reduced cell proliferation...
December 7, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27904703/lncrna-pvt1-overexpression-is-a-poor-prognostic-biomarker-and-regulates-migration-and-invasion-in-small-cell-lung-cancer
#13
Chengsuo Huang, Shuguang Liu, Huijun Wang, Zicheng Zhang, Qing Yang, Fang Gao
PVT1 has been suggested as playing important roles in diverse biological processes including tumorigenesis. However, the clinical significance and biological function of PVT1 in small cell lung cancer (SCLC) is still unclear. The purpose of this study is to identify the role of PVT1 in SCLC. The expression of PVT1 was examined in SCLC tissues and cell lines through real-time PCR. Meanwhile, the relationship of PVT1 expression levels with clinical characteristics of 120 SCLC patients was analyzed. Univariate and multivariate analyses were performed to determine the association between PVT1 expression and prognosis of SCLC patient...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27833074/the-prognostic-value-of-long-non-coding-rnas-in-non-small-cell-lung-cancer-a-meta-analysis
#14
Manni Wang, Xuelei Ma, Chenjing Zhu, Linghong Guo, Qingfang Li, Ming Liu, Jing Zhang
BACKGROUND: Reports have demonstrated the prognostic function of long non-coding RNAS (lncRNAS) in patients with cancer. However, their prognostic functions in non small cell lung cancer (NSCLC) remain controversial. We therefore performed a meta-analysis on six lncRNAs (PVT1, AFAP1-AS1, LINC01133, ANRIL, MEG3 and UCA1) to clarify their prognostic roles in NSCLC. RESULTS: Thirty-six studies involving 6267 patients with NSCLC and 34 lncRNAs were included. Of the listed lncRNAs, 20 were shown to negatively affect patients' overall survival while the high expression of 13 lncRNAs indicated better survival outcomes...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27827314/lncrnas-as-novel-indicators-of-patients-prognosis-in-stage-i-epithelial-ovarian-cancer-a-retrospective-and-multicentric-study
#15
Paolo Martini, Lara Paracchini, Giulia Caratti, Maurizia Mello-Grand, Robert Fruscio, Luca Beltrame, Enrica Calura, Gabriele Sales, Antonella Ravaggi, Eliana Bignotti, Franco E Odicino, Enrico Sartori, Patrizia Perego, Dionyssios Katsaros, Ilaria Craparotta, Giovanna Chiorino, Stefano Cagnin, Laura Mannarino, Lorenzo Ceppi, Costantino Mangioni, Chiara Ghimenti, Maurizio D'Incalci, Sergio Marchini, Chiara Romualdi
PURPOSE: Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs and is characterized by good prognosis with fewer than 20% of patients relapsing. As it occurs less frequently than advanced stage EOC, its molecular features have not been thoroughly investigated. We have demonstrated that in stage I EOC hsa-miR-200c-3p can predict patients' outcome. In the present study, we analyzed the expression of long non-coding RNAs (lncRNAs) to enable potential definition of a non coding transcriptional signature with prognostic relevance for stage I EOC...
November 8, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27813492/long-non-coding-rna-pvt1-promotes-osteosarcoma-development-by-acting-as-a-molecular-sponge-to-regulate-mir-195
#16
Quan Zhou, Fengli Chen, Jiali Zhao, Baojun Li, Yong Liang, Wei Pan, Shaoxian Zhang, Xinhong Wang, Donghui Zheng
A growing body of evidence has indicated that long non-coding RNAs (lncRNAs) serve as competing endogenous RNAs (ceRNAs) during oncogenesis. In this study, the qRT-PCR results indicated that the lncRNA PVT1 is overexpressed in osteosarcoma and decreased the survival rate of osteosarcoma patients. MTT and clonal colony formation assays were used to detect the effect of PVT1 on proliferation, and flow cytometry was performed to assess apoptosis and the cell cycle. A Transwell assay was used to analyze migration and invasion...
November 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27797003/transcriptome-analysis-of-distinct-long-non-coding-rna-transcriptional-fingerprints-in-lung-adenocarcinoma-and-squamous-cell-carcinoma
#17
Yaqiang Wei, Xiaofei Zhang
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related death, including two major pathologic subtypes, adenocarcinoma (AD) and squamous cell carcinoma (SCC). There are significant differences in the aberrant gene profiling and molecular characteristics among LUAD and LUSC, which lead to the different chemotherapeutic regimens administered to the two NSCLC subtypes. Therefore, unique genetic or epigenetic accurately distinguishing these two subtypes is critical for the diagnosis and treatment of patients...
October 29, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27794184/lncrna-pvt1-regulates-prostate-cancer-cell-growth-by-inducing-the-methylation-of-mir-146a
#18
Hong-Tao Liu, Lei Fang, Yu-Xia Cheng, Qing Sun
Prostate cancer is the third most common causes of death from cancer in men. Our previous study demonstrated that lncRNA PVT1 was overexpressed and played an oncogenic role in the progression of prostate cancer. However, the molecular mechanism of modulating the prostate cancer tumorigenesis was still unknown. In this study, we aim to investigate the interaction between PVT1 and miR-146a in prostate cancer and reveal the potential mechanism in prostate cancer carcinogenesis. The expression level of miR-146a was assessed by quantitative RT-PCR...
December 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27775803/long-noncoding-rna-pvt1-as-a-novel-serum-biomarker-for-detection-of-cervical-cancer
#19
J-P Yang, X-J Yang, L Xiao, Y Wang
OBJECTIVE: To investigate long noncoding RNA PVT1 expression in the serum of cervical cancer patients, and to evaluate serum PVT1 level as a diagnostic biomarker for cervical cancer. PATIENTS AND METHODS: Eighty-eight cervical cancer patients, 64 cervical intraepithelial neoplasia patients, 25 breast cancer patients, 25 ovarian cancer patients, and 111 healthy control subjects were enrolled into this study. PVT1 serum level in these participants and PVT1 expression in 20 pairs of cervical cancer tissues and adjacent paired normal tissues was measured by quantitative reverse transcription-polymerase chain reaction...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27774982/genetic-variation-at-the-8q24-21-renal-cancer-susceptibility-locus-affects-hif-binding-to-a-myc-enhancer
#20
Steffen Grampp, James L Platt, Victoria Lauer, Rafik Salama, Franziska Kranz, Viviana K Neumann, Sven Wach, Christine Stöhr, Arndt Hartmann, Kai-Uwe Eckardt, Peter J Ratcliffe, David R Mole, Johannes Schödel
Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel-Lindau tumour suppressor (VHL) and unrestrained activation of hypoxia-inducible transcription factors (HIFs). Genetic and epigenetic determinants have an impact on HIF pathways. A recent genome-wide association study on renal cancer susceptibility identified single-nucleotide polymorphisms (SNPs) in an intergenic region located between the oncogenes MYC and PVT1. Here using assays of chromatin conformation, allele-specific chromatin immunoprecipitation and genome editing, we show that HIF binding to this regulatory element is necessary to trans-activate MYC and PVT1 expression specifically in cells of renal tubular origins...
October 24, 2016: Nature Communications
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