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https://www.readbyqxmd.com/read/28444175/predictive-value-of-telomere-length-on-outcome-following-acute-myocardial-infarction-evidence-for-contrasting-effects-of-vascular-vs-blood-oxidative-stress
#1
Marios Margaritis, Fabio Sanna, George Lazaros, Ioannis Akoumianakis, Sheena Patel, Alexios S Antonopoulos, Chloe Duke, Laura Herdman, Costas Psarros, Evangelos K Oikonomou, Cheerag Shirodaria, Mario Petrou, Rana Sayeed, George Krasopoulos, Regent Lee, Dimitris Tousoulis, Keith M Channon, Charalambos Antoniades
Aims: Experimental evidence suggests that telomere length (TL) is shortened by oxidative DNA damage, reflecting biological aging. We explore the value of blood (BTL) and vascular TL (VTL) as biomarkers of systemic/vascular oxidative stress in humans and test the clinical predictive value of BTL in acute myocardial infarction (AMI). Methods and results: In a prospective cohort of 290 patients surviving recent AMI, BTL measured on admission was a strong predictor of all-cause [hazard ratio (HR) [95% confidence interval (CI)]: 3...
April 24, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28434735/effects-of-graded-removal-of-lysine-from-an-intravenously-infused-amino-acid-mixture-on-lactation-performance-and-mammary-amino-acid-metabolism-in-lactating-goats
#2
C L Guo, Y T Li, X Y Lin, M D Hanigan, Z G Yan, Z Y Hu, Q L Hou, F G Jiang, Z H Wang
To investigate responses of milk protein synthesis and mammary AA metabolism to a graded decrease of postruminal Lys supply, 4 lactating goats fitted with jugular vein, mammary vein, and carotid artery catheters and transonic blood flow detectors on the external pudic artery were used in a 4 × 4 Latin square experiment. Goats were fasted for 24 h and then received a 9-h intravenous infusion of an AA mixture plus glucose. Milk yield was recorded and samples were taken in h 2 to 8 of the infusion period; a mammary biopsy was performed in the last hour...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28422830/management-of-the-extensive-thoracic-defects-after-deep-sternal-wound-infection-with-the-rectus-abdominis-myocutaneous-flap-a-retrospective-case-series
#3
Yue-Hua Li, Zhao Zheng, Jiaomei Yang, Lin-Lin Su, Yang Liu, Fu Han, Jia-Qi Liu, Da-Hai Hu
Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wound management, especially when 1 or 2 internal mammary arteries were absent.Between October 2010 and January 2016, a retrospective review of 9 patients who suffered from the extensive thoracic defects after deep sternal wound infection was conducted...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28416323/review-of-coronary-subclavian-steal-syndrome
#4
REVIEW
Bennett Cua, Natasha Mamdani, David Halpin, Sunny Jhamnani, Sasanka Jayasuriya, Carlos Mena-Hurtado
The clinical benefits of using the left internal mammary artery (LIMA) to bypass the left anterior descending artery are well established making it the most frequently used conduit for coronary artery bypass surgery (CABG). Coronary subclavian steal syndrome (CSSS) occurs during left arm exertion when (1) the LIMA is used during bypass surgery and (2) there is a high grade (≥75%) left subclavian artery stenosis or occlusion proximal to the ostia of the LIMA resulting in "stealing" of the myocardial blood supply via retrograde flow up the LIMA graft to maintain left upper extremity perfusion...
April 14, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28414054/endothelium-dependent-vasorelaxant-effect-of-procyanidin-b2-on-human-internal-mammary-artery
#5
Aleksandra Novakovic, Marija Marinko, Goran Jankovic, Ivan Stojanovic, Predrag Milojevic, Dragoslav Nenezic, Vladimir Kanjuh, Qin Yang, Guo-Wei He
The aim of the present study was to investigate and characterize vasorelaxant effect of procyanidin B2 on human internal mammary artery (HIMA) as one of the mechanisms of its protective effect against vascular risk. Procyanidin B2 induced strong concentration-dependent relaxation of HIMA rings pre-contracted by phenylephrine. Pretreatment with L-NAME, a NO synthase inhibitor, hydroxocobalamin, a NO scavenger, and ODQ, an inhibitor of soluble guanylate cyclase, significantly inhibited procyanidin B2-induced relaxation of HIMA, while indomethacin, a cyclooxygenase inhibitor, considerably reduced effects of low concentrations...
April 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28402472/direct-sternal-administration-of-vancomycin-and-gentamicin-during-closure-prevents-wound-infection%C3%A2
#6
Martin Andreas, Moritz Muckenhuber, Doris Hutschala, Alfred Kocher, Florian Thalhammer, Paul Vogt, Tatjana Fleck, Guenther Laufer
OBJECTIVES: Deep sternal wound infection is still a major complication in patients undergoing cardiac surgery. We previously identified mammary artery harvesting as a risk factor for decreased antibiotic tissue penetration. In addition, other risk factors including diabetes may inhibit sufficient tissue penetration of perioperative antibiotic prophylaxis. A novel closure protocol applying 2 topical antibiotics and further recommendations for sternal wiring was introduced at our department to decrease the incidence of sternal wound infections...
April 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28401711/screening-for-subclinical-subclavian-artery-stenosis-before-coronary-artery-bypass-grafting-should-we-do-it
#7
REVIEW
Ali Abdul Jabbar, Justin Houston, Mark Burket, Zachary J Il'Giovine, Bal K Srivastava, Ajay Agarwal
Atherosclerotic subclavian artery disease is detected in about 5% of patients referred for coronary artery bypass (CABG) surgery. The internal mammary artery, a branch of the subclavian artery, is the most frequently utilized graft to restore coronary circulation because of its longevity. Stenosis or occlusion of the subclavian artery can cause retrograde blood flow in the ipsilateral internal mammary artery, known as "steal," compromising coronary circulation supplied by the graft. Steal may be asymptomatic or may result in symptoms of myocardial ischemia...
April 12, 2017: Echocardiography
https://www.readbyqxmd.com/read/28401193/intravascular-treatment-of-left-subclavian-artery-aneurysm-coexisting-with-aortic-coarctation-in-an-adult-patient
#8
Ryszard Pogorzelski, Tomasz Wołoszko, Sadegh Toutounchi, Patryk Fiszer, Ewa Krajewska, Wawrzyniec Jakuczun, Małgorzata M Szostek, Krzysztof Celejewski, Zbigniew Gałązka
Coexistence of aortic coarctation with aneurysm of subclavian artery is a uncommon situation and may require unusual treatment in patients. A 40-year-old patient diagnosed incidentally with left subclavian artery aneurysm coexisting with aortic coarctation. Patient was initially referred for hybrid treatment. Initially ostium of the left subclavian artery was covered with a stent-graft. Over a 30-month follow-up period aneurysm became thrombosed all the way up to the ostium of internal mammary artery. The patient did not present with neurological symptoms or signs of upper limb ischemia...
January 2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28396618/apixaban-for-the-treatment-of-saphenous-vein-graft-thrombosis-presenting-as-unstable-angina-a-case-report
#9
Makoto Saigan, Tsuyoshi Isawa, Tatsushi Ootomo
BACKGROUND: Saphenous vein graft thrombosis can present as unstable angina. However, percutaneous coronary intervention for saphenous vein graft lesions poses a high risk of slow flow related to the procedure. Here we present the utilization of the novel oral anticoagulant, apixaban, in the treatment of unstable angina with extensive saphenous vein graft thrombus, leading to considerable thrombus resolution and eliminating the need of percutaneous coronary intervention. CASE PRESENTATION: A 72-year-old man with 3-vessel coronary artery bypass graft surgery using a saphenous vein graft and a left internal mammary artery, performed 25 years earlier, presented at our hospital with recurrent chest tightness...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28389717/sex-difference-in-expression-and-function-of-beta-adrenoceptors-in-macrovessels-role-of-the-endothelium
#10
Suzan Al-Gburi, Andreas Deussen, Birgit Zatschler, Silvio Weber, Stephan Künzel, Ali El-Armouche, Kristina Lorenz, Maria Cybularz, Henning Morawietz, Irakli Kopaliani
Estrogen modulates adrenergic reactivity of macrovessels, resulting in weaker α-adrenergic vasoconstriction in females than males. However, the mechanisms governing this important sex-specific difference are not well understood. We hypothesized that vessels of females express more dilatory β-adrenoceptors, which counteract constrictive effects of α-adrenoceptors. This hypothesis was tested using aortas of normotensive (WKY) and hypertensive rats (SHR), along with human mammary artery. Selective blockade of β1 (CGP20712) or β3 (SR59230A), but not β2 (ICI118,551) adrenoceptors, greatly increased α-adrenergic constriction (norepinephrine) of aorta in female SHRs, but not in male SHRs at 12 weeks of age...
May 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28388767/treatment-of-coronary-artery-disease-randomized-trials-on-myocardial-revascularization-and-complete-arterial-bypass-grafting
#11
Ardawan J Rastan
Friedrich Wilhelm Mohr from the very beginning of his career as a cardiac surgeon was involved in the refinements of coronary artery bypass grafting (CABG). At the Leipzig Heart Center, his spirit of early adapting to new technologies inspired the entire team and led to a matchless scientific atmosphere to find solutions to improve almost all fields of cardiac surgery, including CABG. In combination with a tremendous number of patients with indications for isolated coronary artery bypass Prof. Mohr as the surgical principle investigator and the Leipzig Heart Center were able to include patients in the Synergy between PCI [percutaneous coronary intervention] with Taxus and Cardiac Surgery (SYNTAX) trial, the first randomized trials comparing CABG and PCIs using the drug-eluting stents...
April 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28386230/role-of-nadph-oxidase-4-in-human-endothelial-progenitor-cells
#12
Nora Y Hakami, Amaresh K Ranjan, Anandwardhan A Hardikar, Greg J Dusting, Hitesh M Peshavariya
Introduction: Endothelial progenitor cells (EPCs) display a unique ability to promote angiogenesis and restore endothelial function in injured blood vessels. NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H2O2) serves as a signaling molecule and promotes endothelial cell proliferation and migration as well as protecting against cell death. However, the role of NOX4 in EPC function is not completely understood. Methods: EPCs were isolated from human saphenous vein and mammary artery discarded during bypass surgery...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28385576/blood-transfusions-may-impair-endothelium-dependent-vasodilatation-during-coronary-artery-bypass-surgery
#13
Alessio Rungatscher, Elisabetta Milani, Cecilia Covajes, Seth Hallström, Leonardo Gottin, Gian Cesare Guidi, Giovanni Battista Luciani, Giuseppe Faggian
OBJECTIVE: The hemolytic product free-hemoglobin (fHb) reduces nitric oxide (NO) bioavailability. The present study aims to establish whether administration of different blood transfusions result in increased circulating fHb levels and NO consumption with effects on arterial NO-dependent blood flow in patients undergoing CABG surgery. METHODS: Ninety-five consecutive patients undergoing elective CABG surgery were prospectively divided in four groups based on blood transfusion requirements during surgery: stored blood cells (SBC, n...
April 4, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28379404/a-prospective-study-of-external-stenting-of-saphenous-vein-grafts-to-the-right-coronary-artery-the-vest-ii-study
#14
David P Taggart, Sanaz Amin, Jasmina Djordjevic, Evangelos K Oikonomou, Sheena Thomas, Anna-Maria Kampoli, Nikant Sabharwal, Charalambos Antoniades, George Krasopoulos
OBJECTIVES: External stents significantly reduce intimal hyperplasia and improve lumen uniformity and flow pattern in saphenous vein grafts (SVG) 1 year after coronary artery bypass grafting. However, recent studies have shown that at 1 year there is a lower patency of externally stented SVG to the right coronary artery (RCA) (55-60%) when compared to the left sided coronary arteries (85-90%). In the current study, we investigated whether avoidance of both fixation of the external stent to the anastomoses and the use of metal clips to ligate SVG side branches would improve the early patency of externally stented SVG to the RCA...
May 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28373136/decreased-vasorelaxation-induced-by-iloprost-during-acute-inflammation-in-human-internal-mammary-artery
#15
Nabil Foudi, Gulsev Ozen, Yasmine Amgoud, Liliane Louedec, Christine Choqueux, Aouatef Badi, Larissa Kotelevets, Eric Chastre, Dan Longrois, Xavier Norel
Cyclooxygenase-2 (COX-2) induction in human internal mammary arteries (IMA) under inflammatory conditions has been associated with attenuated norepinephrine (NE)-induced vasoconstriction. This effect was associated with increased prostaglandin (PG) E2 and prostacyclin (PGI2) releases. The present study was designed to assess the role of these PG and their receptors (EP and IP, respectively) on the vascular reactivity during acute inflammation. Isolated IMA were cultured in the absence (Control conditions) or presence (Inflammatory conditions) of both interleukin-1 beta (IL-1β) and lipopolysaccharide (LPS)...
June 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28360194/neuronal-nitric-oxide-synthase-derived-hydrogen-peroxide-effect-in-grafts-used-in-human-coronary-bypass-surgery
#16
Patrick Wander Endlich, Rosária Dias Aires, Roberta Lins Gonçalves, Eduardo Damasceno Costa, Janaína de Paula Arantes Ângelo, Lucas Ferreira Alves, Rafaela Fernandes da Silva, Bruno Almeida Rezende, Steyner F Cortes, Virgínia S Lemos
Recently, H2O2 has been identified as the endothelium-dependent hyperpolarizing factor (EDHF), which mediates flow-induced dilation in human coronary arteries. Neuronal nitric oxide synthase (nNOS) is expressed in the cardiovascular system and besides NO, generates H2O2 The role of nNOS-derived H2O2 in human vessels is so far unknown. The present study aimed at investigating the relevance of nNOS/H2O2 signaling in human internal mammary artery (IMA) and saphenous vein (SV), the major conduits used in coronary artery bypass grafting...
March 30, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28359484/occult-internal-mammary-artery-neurofibromatosis-a-case-for-caution-in-coronary-revascularization
#17
Stefanos Boukovalas, Myrto Boukovala, Patrick T Roughneen, Suimmin Qiu, Ghannam A Al-Dossari
Intrathoracic neurofibromas are relatively uncommon in patients with neurofibromatosis. They are usually asymptomatic and may be discovered incidentally. We present the case of a 51-year-old, African American man with neurofibromatosis type 1 who underwent coronary revascularization. Intraoperatively, numerous neurofibromas were discovered, one of which was attached to the left internal mammary artery. The procedure was uncomplicated despite the challenging intraoperative findings. Special considerations in the management of patients with neurofibromatosis undergoing cardiac surgery are discussed, including risks, preoperative imaging and the importance of excision of suspicious tumors...
April 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28355655/coronary-artery-bypass-surgery-in-diffuse-advanced-coronary-artery-disease-1-year-clinical-and-angiographic-results
#18
Luciana Oliveira Cascaes Dourado, Marcio Sommer Bittencourt, Alexandre Costa Pereira, Nilson Tavares Poppi, Luis Alberto Oliveira Dallan, José Eduardo Krieger, Luiz Antonio Machado Cesar, Luís Henrique Wolff Gowdak
Background Proper treatment of patients with diffuse, severe coronary artery disease (CAD) is a challenge due to its complexity. Thus, data on the outcomes after coronary artery bypass graft (CABG) in this population is scarce. In this study, we aimed to determine the impact of CABG on the clinical and functional status, as well as graft patency in those individuals. Methods Patients with severe and diffuse CAD who underwent incomplete CABG due to complex anatomy or extensive distal coronary involvement were evaluated preoperatively and 1 year after surgery...
March 29, 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28340668/anastomosis-of-the-superficial-inferior-epigastric-vein-to-the-internal-mammary-vein-to-augment-deep-inferior-artery-perforator-flaps
#19
REVIEW
Aparna Vijayasekaran, Anita T Mohan, Lin Zhu, Basel Sharaf, Michel Saint-Cyr
Use of the retrograde limb of the internal mammary vein has been described previously as a lifeboat for venous congestion but not prophylactically. Maximizing the length of the deep inferior artery perforator (DIEP) flap pedicle, identifying and dissecting the superficial inferior epigastric vein proximally in every patient, and taking advantage of the retrograde internal mammary vein are all technical details that facilitate the additional venous anastomosis and flap inset. Performing a second venous anastomosis routinely using the superficial inferior epigastric vein to the retrograde internal mammary vein helps with flap inset...
April 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28325774/erratum-expression-of-growth-arrest-specific-protein-6-and-axl-molecules-in-the-left-internal-mammary-artery-of-patients-undergoing-coronary-artery-bypass-grafting
#20
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Clinical Pathology
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