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Paul M Busse, Otto K Harling, Matthew R Palmer, W S Kiger, Jody Kaplan, Irving Kaplan, Cynthia F Chuang, J Tim Goorley, Kent J Riley, Thomas H Newton, Gustavo A Santa Cruz, Xing-Qi Lu, Robert G Zamenhof
A phase I trial was designed to evaluate normal tissue tolerance to neutron capture therapy (NCT); tumor response was also followed as a secondary endpoint. Between July 1996 and May 1999, 24 subjects were entered into a phase I trial evaluating cranial NCT in subjects with primary or metastatic brain tumors. Two subjects were excluded due to a decline in their performance status and 22 subjects were irradiated at the MIT Nuclear Reactor Laboratory. The median age was 56 years (range 24-78). All subjects had a pathologically confirmed diagnosis of either glioblastoma (20) or melanoma (2) and a Karnofsky of 70 or higher...
March 2003: Journal of Neuro-oncology
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