Colette Christiansen, Louis Potier, Tiphaine C Martin, Sergio Villicaña, Juan E Castillo-Fernandez, Massimo Mangino, Cristina Menni, Pei-Chien Tsai, Purdey J Campbell, Shelby Mullin, Juan R Ordoñana, Olga Monteagudo, Perminder S Sachdev, Karen A Mather, Julian N Trollor, Kirsi H Pietilainen, Miina Ollikainen, Christine Dalgård, Kirsten Kyvik, Kaare Christensen, Jenny van Dongen, Gonneke Willemsen, Dorret I Boomsma, Patrik K E Magnusson, Nancy L Pedersen, Scott G Wilson, Elin Grundberg, Tim D Spector, Jordana T Bell
BACKGROUND: Type 2 diabetes (T2D) susceptibility is influenced by genetic and environmental factors. Previous findings suggest DNA methylation as a potential mechanism in T2D pathogenesis and progression. METHODS: We profiled DNA methylation in 248 blood samples from participants of European ancestry from 7 twin cohorts using a methylation sequencing platform targeting regulatory genomic regions encompassing 2,048,698 CpG sites. FINDINGS: We find and replicate 3 previously unreported T2D differentially methylated CpG positions (T2D-DMPs) at FDR 5% in RGL3, NGB and OTX2, and 20 signals at FDR 25%, of which 14 replicated...
April 3, 2024: EBioMedicine