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https://www.readbyqxmd.com/read/29043999/study-of-global-dna-methylation-in-monozygotic-twins-with-cerebral-palsy
#1
Yuxiao Yuan
The objective of this paper is to study the global DNA Methylation in monozygotic (MZ) twins with cerebral palsy. Two pairs of twins (a cerebral palsy children, a normal child) admitted to the First Affiliated Hospital of Zhengzhou University were selected as subjects. The phenol-chloroform method was used to extract DNA from venous blood and micro satellite DNA genotyping technique was used to identify the eggs of the twins. DNA methylation fragments were enriched by MBD affinity column chromatography, followed by Solexa sequencing and bioinformatics analysis...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29042182/are-endocrine-disrupting-compounds-environmental-risk-factors-for-autism-spectrum-disorder
#2
REVIEW
Amer Moosa, Henry Shu, Tewarit Sarachana, Valerie W Hu
Recent research on the etiology of autism spectrum disorder (ASD) has shifted in part from a singular focus on genetic causes to the involvement of environmental factors and their gene interactions. This shift in focus is a result of the rapidly increasing prevalence of ASD coupled with the incomplete penetrance of this disorder in monozygotic twins. One such area of environmentally focused research is the association of exposures to endocrine disrupting compounds (EDCs) with elevated risk for ASD. EDCs are exogenous chemicals that can alter endogenous hormone activity and homeostasis, thus potentially disrupting the action of sex and other natural hormones at all stages of human development...
October 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29039147/heritability-of-addison-s-disease-and-prevalence-of-associated-autoimmunity-in-a-cohort-of-112-100-swedish-twins
#3
Jakob Skov, Jonas Höijer, Patrik K E Magnusson, Jonas F Ludvigsson, Olle Kämpe, Sophie Bensing
PURPOSE: The pathophysiology behind autoimmune Addison's disease (AAD) is poorly understood, and the relative influence of genetic and environmental factors remains unclear. In this study, we examined the heritability of AAD and explored disease-associated autoimmune comorbidity among Swedish twins. METHODS: A population-based longitudinal cohort of 112,100 Swedish twins was used to calculate the heritability of AAD, and to explore co-occurrence of 10 organ-specific autoimmune disorders in twin pairs with AAD...
October 16, 2017: Endocrine
https://www.readbyqxmd.com/read/29037589/a-twin-purification-enrichment-procedure-based-on-two-versatile-solid-liquid-extracting-agents-for-efficient-uptake-of-ultra-trace-levels-of-lorazepam-and-clonazepam-from-complex-bio-matrices
#4
Maryam Hemmati, Maryam Rajabi, Alireza Asghari
In this research work, two consecutive dispersive solid/liquid phase microextractions based on efficient extraction media were developed for the influential and clean pre-concentration of clonazepam and lorazepam from complicated bio-samples. The magnetism nature of the proposed nanoadsorbent proceeded the clean-up step conveniently and swiftly (∼5min), pursued by a further enrichment via a highly effective and rapid emulsification microextraction process (∼4min) based on a deep eutectic solvent (DES). Finally, the instrumental analysis step was practicable via high performance liquid chromatography-ultraviolet detection...
September 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29032046/past-present-and-future-of-genetic-research-in-borderline-personality-disorder
#5
REVIEW
Anahita Bassir Nia, Matthew C Eveleth, Jonathan M Gabbay, Yonis J Hassan, Bosi Zhang, M Mercedes Perez-Rodriguez
Borderline Personality Disorder (BPD) is a major mental illness with a lifetime prevalence of approximately 1-3%, characterized by a persistent pattern of instability in relationships, mood, impulse regulation, and sense of self. This results in impulsive self-damaging behavior, high suicide rates, and severe functional impairment. BPD has a complex, multifactorial etiology, resulting from an interaction among genetic and environmental substrates, and has moderate to high heritability based on twin and family studies...
September 12, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29031020/fetal-mri-lower-acceptance-by-women-in-research-vs-clinical-setting
#6
Bloeme J van der Knoop, Roland J Vermeulen, Jonathan I M L Verbeke, Lourens R Pistorius, Johanna I P de Vries
AIM: To determine acceptance of pregnant women to undergo fetal magnetic resonance imaging (MRI) examination in research and clinical setting. METHODS: A prospective study included a research group [part of a study comparing brain ultrasound (US) to MRI in fetuses at risk for acquired brain damage] and a clinical group [fetuses with suspected (brain) anomalies after structural US examination] from 2011 to 2014. All women were advised to use sedatives. MRI declinations, use of sedation, MRI duration and imaging quality were compared between both groups...
October 14, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29028139/birthweight-discordance-and-neonatal-morbidity-in-twin-pregnancies-analysis-of-the-stork-multiple-pregnancy-cohort
#7
Francesco D'Antonio, Basky Thilaganathan, Arianna Laoreti, Asma Khalil
OBJECTIVES: The main aim of this study was to investigate the relationship between weight discordance and neonatal morbidity in twin pregnancies progressing beyond 34 weeks of gestation. The secondary aim was to determine the predictive accuracy of different weight discordant cut-offs in predicting neonatal morbidity in twin pregnancies. METHODS: This was a retrospective multicentre cohort study of all twin pregnancies booked for antenatal care in four hospitals in the Southwest Thames region of London Obstetric Research Collaborative (STORK) over a period of ten years...
October 13, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29025107/vanishing-twin-syndrome-among-art-singletons-and-pregnancy-outcomes
#8
Maria C Magnus, Sara Ghaderi, Nils-Halvdan Morken, Per Magnus, Liv Bente Romundstad, Rolv Skjærven, Allen J Wilcox, Siri Eldevik Håberg
STUDY QUESTION: Among babies born by ART, do singleton survivors of a vanishing twin have lower birth weight than other singletons? SUMMARY ANSWER: Vanishing twin syndrome (VTS) was associated with lower birth weight among ART singletons; a sibship analysis indicated that the association was not confounded by maternal characteristics that remain stable between deliveries. WHAT IS KNOWN ALREADY: Previous studies indicate that ART singletons with VTS have increased risk of adverse pregnancy outcomes, compared with other ART singletons...
August 31, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29021003/seasonality-in-multiple-maternities
#9
Johan Fellman
In the 19th century, a series of international statistical congresses introduced common rules for the national demographic registers. This activity contributed to the genesis of statistical research. During the history of twin research, Hellin's law has played a central role because it is an approximately correct association between the rates of multiple maternities. However, it has been mathematically proven that Hellin's law cannot hold exactly. The majority of all studies of Hellin's law are based on empirical rates of multiple maternities...
October 12, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29017064/negative-social-comparisons-and-psychosis-proneness-in-a-healthy-adolescent-population
#10
F A Cotier, T Toulopoulou
There is growing evidence of an association between negative social comparisons (NSC) and both psychosis, and psychosis proneness. The majority of the work thus far, however, has focused largely on one type of NSC, namely, social rank. Whilst social rank is clearly an important factor, an individual's perception of belonging is likely also of importance; particularly, when considering individuals from collectivistic cultures such as China, where greater emphasis is placed on fitting into the group. There is also limited research investigating what factors may contribute towards the relationship between NSC and psychosis proneness, and to what extent this relationship may be due to common familial factors...
September 1, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28992894/chronic-prostatitis-and-comorbid-non-urological-overlapping-pain-conditions-a-co-twin-control-study
#11
Marianna Gasperi, John N Krieger, Christopher Forsberg, Jack Goldberg, Dedra Buchwald, Niloofar Afari
OBJECTIVES: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is characterized by pain and voiding symptoms in the absence of an obvious infection or other cause. CP/CPPS frequently occurs with non-urological chronic overlapping pain conditions (COPCs) of unknown etiology. We conducted a co-twin control study in men discordant for chronic prostatitis (CP), an overarching diagnosis of which approximately 90% is CP/CPPS. The primary aim was to investigate the contribution of familial factors, including shared genetic and common environmental factors, to the comorbidity of CP and COPCs...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28987712/heritability-of-schizophrenia-and-schizophrenia-spectrum-based-on-the-nationwide-danish-twin-register
#12
Rikke Hilker, Dorte Helenius, Birgitte Fagerlund, Axel Skytthe, Kaare Christensen, Thomas M Werge, Merete Nordentoft, Birte Glenthøj
BACKGROUND: Twin studies have provided evidence that both genetic and environmental factors contribute to schizophrenia (SZ) risk. Heritability estimates of SZ in twin samples have varied methodologically. This study provides updated heritability estimates based on nationwide twin data and an improved statistical methodology. METHODS: Combining two nationwide registers, the Danish Twin Register and the Danish Psychiatric Research Register, we identified a sample of twins born between 1951 and 2000 (N = 31,524 twin pairs)...
September 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28985290/shared-genetic-influence-on-frailty-and-chronic-widespread-pain-a-study-from-twinsuk
#13
Gregory Livshits, Mary Ni Lochlainn, Ida Malkin, Ruth Bowyer, Serena Verdi, Claire J Steves, Frances M K Williams
Introduction: frailty is an increased vulnerability to adverse health outcomes, across multiple physiological systems, with both environmental and genetic drivers. The two most commonly used measures are Rockwood's frailty index (FI) and Fried's frailty phenotype (FP). Material and methods: the present study included 3626 individuals from the TwinsUK Adult Twin Registry. We used the classical twin model to determine whether FI and FP share the same latent aetiological factors...
July 7, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28981896/protective-factors-for-psychotic-symptoms-among-poly-victimized-children
#14
Eloise Crush, Louise Arseneault, Sara R Jaffee, Andrea Danese, Helen L Fisher
Background: Experiencing victimization in early life has been repeatedly shown to be associated with the emergence of psychotic symptoms in childhood. However, most victimized children do not develop psychotic symptoms and why this occurs is not fully understood. This study investigated which individual, family-level, and wider community characteristics were associated with an absence of psychotic symptoms among children at risk for psychosis by virtue of their exposure to multiple victimization experiences (poly-victimization)...
August 31, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28978986/the-relationship-between-obesity-and-hypertension-an-updated-comprehensive-overview-on-vicious-twins
#15
REVIEW
Massimo Leggio, Mario Lombardi, Elisa Caldarone, Paolo Severi, Stefania D'Emidio, Massimo Armeni, Veronica Bravi, Maria Grazia Bendini, Andrea Mazza
Obesity is a growing global health concern, with a rapid increase being observed in morbid obesity. Obesity is associated with an increased cardiovascular risk and earlier onset of cardiovascular morbidity. The growing obesity epidemic is a major source of unsustainable health costs and morbidity and mortality because of hypertension, type 2 diabetes mellitus, dyslipidemia, certain cancers and major cardiovascular diseases. Similar to obesity, hypertension is a key unfavorable health metric that has disastrous health implications: currently, hypertension is the leading contributor to global disease burden, and the direct and indirect costs of treating hypertension are exponentially higher...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28978539/maternal-weight-gain-and-associations-with-longitudinal-fetal-growth-in-dichorionic-twin-pregnancies-a-prospective-cohort-study
#16
Stefanie N Hinkle, Mary L Hediger, Sungduk Kim, Paul S Albert, William Grobman, Roger B Newman, Deborah A Wing, Jagteshwar Grewal, Cuilin Zhang, Germaine M Buck Louis, Katherine L Grantz
Background: Maternal metabolic demands are much greater with twin gestations; however, there are no accepted recommendations for maternal weight gain in twin pregnancies.Objective: We assessed the association of maternal weight gain and fetal growth in dichorionic twins throughout pregnancy.Design: This was a prospective US cohort study (n = 143, 2012-2013) of dichorionic twin pregnancies with known birth outcomes followed from enrollment (11-13 wk) and for ≤6 research visits throughout gestation. Maternal prepregnancy weight was self-reported, and current weight was measured at each research visit and abstracted from prenatal records...
October 4, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28975876/twin-studies-in-brazil-projects-and-plans-twin-research-infant-twins-viewing-of-social-scenes-religiosity-and-substance-abuse-down-syndrome-among-twins-twin-case-of-chronic-periodontitis-in-the-news-the-twin-property-brothers-twins-with-cerebral-palsy-twins
#17
Nancy L Segal
Twin research in Brazil twin has expanded enormously in recent years, engaging the interests and efforts of many investigators, students and twins. Descriptions and brief summaries of this work and talks given by investigators at local conferences are presented, based on my four-city lecture tour. This is followed by summaries of twin research on infants' viewing of social scenes, religiosity and substance abuse, Down syndrome, and chronic periodontitis. This article concludes with twin-related news and information of general interest, including identical twin property designers, twins with cerebral palsy, twins affected with the Zika virus, a pair of twin writers, twins in sports, and a set of quadruplets from my childhood neighborhood in Riverdale, New York...
October 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28971522/half-a-century-of-equine-reproduction-research-and-application-a-veterinary-tour-de-force
#18
REVIEW
Twink W R Allen, S Wilsher
Over the past 50 years, pregnancy rates in Thoroughbred mares have risen from 70 to >90% and foaling rates from 55 to >80%. Some of the significant pharmacological treatments and diagnostic methods which have driven this marked improvement in breeding efficiency are reviewed. They include the application of artificial lighting to hasten the onset of ovulatory oestrous cyclicity in early Spring, rapid steroid hormone assays to aid in determining the stage and normality of the mare's cycle, prostaglandin analogues, synthetic progestagens and Gonadotrophin-releasing Hormone (GnRH) analogues to better control and manipulate her cycle to good effect, transrectal ultrasound scanning to monitor follicle growth, endometrial architecture and ovulation and to allow accurate, early pregnancy diagnosis thereby enabling successful ablation of one of twin conceptuses...
October 3, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28967605/-22q11-2%C3%A2-microdeletion-syndrome-analysis-of-the-care-pathway-before-the-genetic-diagnosis
#19
T Ingrao, L Lambert, M Valduga, G Bosser, E Albuisson, B Leheup
BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is a very broad phenotypic spectrum disorder. It can affect many organs or systems. 22q11.2DS is the most common microdeletion syndrome in humans, with a prevalence ranging from one in every 2000 to one in 4000 newborns. It seems to be more prevalent than reported and under-recognized or undiagnosed because of its inherent clinical variability and heterogeneity. In France, 15,000 patients may be affected by this disease, more than half without knowing it...
September 26, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28965006/measuring-childhood-maltreatment-to-predict-early-adult-psychopathology-comparison-of-prospective-informant-reports-and-retrospective-self-reports
#20
Joanne B Newbury, Louise Arseneault, Terrie E Moffitt, Avshalom Caspi, Andrea Danese, Jessie R Baldwin, Helen L Fisher
Both prospective informant-reports and retrospective self-reports may be used to measure childhood maltreatment, though both methods entail potential limitations such as underestimation and memory biases. The validity and utility of standard measures of childhood maltreatment requires clarification in order to inform the design of future studies investigating the mental health consequences of maltreatment. The present study assessed agreement between prospective informant-reports and retrospective self-reports of childhood maltreatment, as well as the comparative utility of both reports for predicting a range of psychiatric problems at age 18...
September 21, 2017: Journal of Psychiatric Research
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