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https://www.readbyqxmd.com/read/28899546/exploring-the-nap-paradox-are-mid-day-sleep-bouts-a-friend-or-foe
#1
REVIEW
Janna Mantua, Rebecca M C Spencer
The mid-day nap, sometimes called a siesta, is a ubiquitous occurrence across the lifespan. It is well established that in addition to reducing sleepiness, mid-day naps offer a variety of benefits: memory consolidation, preparation for subsequent learning, executive functioning enhancement, and a boost in emotional stability. These benefits are present even if a sufficient amount of sleep is obtained during the night prior. However, we present a paradox: in spite of these reported benefits of naps, frequent napping has also been associated with numerous negative outcomes (eg, cognitive decline, hypertension, diabetes), particularly in older populations...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28851647/mechanisms-of-sleep-plasticity-due-to-sexual-experience-in-drosophila-melanogaster
#2
Abigail E Dove, Brianne L Cook, Zhazira Irgebay, Christopher G Vecsey
Sleep can be altered by an organism's previous experience. For instance, female Drosophila melanogaster experience a post-mating reduction in daytime sleep that is purportedly mediated by sex peptide (SP), one of many seminal fluid proteins (SFPs) transferred from male to female during mating. In the present study, we first characterized this mating effect on sleep more fully, as it had previously only been tested in young flies under 12h light/12h dark conditions. We found that mating reduced sleep equivalently in 3-day-old or 14-day-old females, and could even occur in females who had been mated previously, suggesting that there is not a developmental critical period for the suppression of sleep by mating...
August 26, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28840790/a-new-rhodopsin-influences-light-dependent-daily-activity-patterns-of-fruit-flies
#3
Christa Kistenpfennig, Rudi Grebler, Maite Ogueta, Christiane Hermann-Luibl, Matthias Schlichting, Ralf Stanewsky, Pingkalai R Senthilan, Charlotte Helfrich-Förster
Rhodopsin 7 ( Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000, but its function has remained elusive. We generated an Rh7 null mutant ( Rh7(0)) by P element-mediated mutagenesis and found that an absence of Rh7 had significant effects on fly activity patterns during light-dark (LD) cycles: Rh7(0) mutants exhibited less morning activity and a longer siesta than wild-type controls. Consistent with these results, we found that Rh7 appears to be expressed in a few dorsal clock neurons that have been previously implicated in the control of the siesta...
August 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28596192/the-impact-of-conscious-sedation-versus-general-anesthesia-for-stroke-thrombectomy-on-the-predictive-value-of-collateral-status-a-post-hoc-analysis-of-the-siesta-trial
#4
S Schönenberger, J Pfaff, L Uhlmann, C Klose, S Nagel, P A Ringleb, W Hacke, M Kieser, M Bendszus, M A Möhlenbruch, J Bösel
BACKGROUND AND PURPOSE: Radiologic selection criteria to identify patients likely to benefit from endovascular stroke treatment are still controversial. In this post hoc analysis of the recent randomized Sedation versus Intubation for Endovascular Stroke TreAtment (SIESTA) trial, we aimed to investigate the impact of sedation mode (conscious sedation versus general anesthesia) on the predictive value of collateral status. MATERIALS AND METHODS: Using imaging data from SIESTA, we assessed collateral status with the collateral score of Tan et al and graded it from absent to good collaterals (0 -3)...
June 8, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28529921/mediterranean-lifestyle-and-cardiovascular-disease-prevention
#5
Ekavi N Georgousopoulou, Duane D Mellor, Nenad Naumovski, Evangelos Polychronopoulos, Stefanos Tyrovolas, Suzanne Piscopo, Giuseppe Valacchi, Foteini Anastasiou, Akis Zeimbekis, Vassiliki Bountziouka, Efthimios Gotsis, George Metallinos, Dimitra Tyrovola, Alexandra Foscolou, Josep-Antoni Tur, Antonia-Leda Matalas, Christos Lionis, Labros Sidossis, Demosthenes Panagiotakos
BACKGROUND: Adherence to a Mediterranean dietary pattern is a well-established protective factor against cardiovascular disease (CVD). However, diet quality is only one aspect of the overall healthy lifestyle adopted by Mediterranean populations. The latter has never been evaluated as a multi-factorial composite lifestyle. Thus, the aim of the present study was to provide a broader picture of the Mediterranean lifestyle and its effects on CVD risk, among elderly individuals. METHODS: During 2005-2015, 2,749 older (aged 65-100 years) from 21 Mediterranean islands (MEDIS) and the rural Mani region (Peloponnesus) of Greece were voluntarily enrolled onto the study...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28316636/the-siesta-trial-a-randomized-study-investigating-the-efficacy-safety-and-tolerability-of-acupressure-versus-sham-therapy-for-improving-sleep-quality-in-patients-with-end-stage-kidney-disease-on-hemodialysis
#6
Kunyu Shen, Yeoungjee Cho, Elaine M Pascoe, Carmel M Hawley, Veronica Oliver, Kathryn M Hughes, Richard Baer, Jeremy Frazier, Elizabeth Jarvis, Ken-Soon Tan, Xusheng Liu, Glenda Gobe, David W Johnson
Objectives. To compare the effectiveness of real acupressure versus sham acupressure therapy in improving sleep quality in patients receiving hemodialysis (HD) or hemodiafiltration (HDF). Methods. A multicenter, single-blind, randomized controlled trial was conducted in two Australian dialysis units located in Princess Alexandra Hospital and Logan Hospital, respectively. Forty-two subjects with self-reported poor sleep quality were randomly assigned to real (n = 21) or sham (n = 21) acupressure therapy delivered thrice weekly for four consecutive weeks during routine dialysis sessions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28252536/a-quantile-analysis-of-plateau-and-driving-pressures-effects-on-mortality-in-patients-with-acute-respiratory-distress-syndrome-receiving-lung-protective-ventilation
#7
Jesús Villar, Carmen Martín-Rodríguez, Ana M Domínguez-Berrot, Lorena Fernández, Carlos Ferrando, Juan A Soler, Ana M Díaz-Lamas, Elena González-Higueras, Leonor Nogales, Alfonso Ambrós, Demetrio Carriedo, Mónica Hernández, Domingo Martínez, Jesús Blanco, Javier Belda, Dácil Parrilla, Fernando Suárez-Sipmann, Concepción Tarancón, Juan M Mora-Ordoñez, Lluís Blanch, Lina Pérez-Méndez, Rosa L Fernández, Robert M Kacmarek
OBJECTIVES: The driving pressure (plateau pressure minus positive end-expiratory pressure) has been suggested as the major determinant for the beneficial effects of lung-protective ventilation. We tested whether driving pressure was superior to the variables that define it in predicting outcome in patients with acute respiratory distress syndrome. DESIGN: A secondary analysis of existing data from previously reported observational studies. SETTING: A network of ICUs...
May 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28124071/siesta-thrombectomy-as-you-like
#8
EDITORIAL
Martin Bendszus
No abstract text is available yet for this article.
March 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28114910/mid-day-siesta-in-natural-populations-of-d-melanogaster-from-africa-exhibits-an-altitudinal-cline-and-is-regulated-by-splicing-of-a-thermosensitive-intron-in-the-period-clock-gene
#9
Weihuan Cao, Isaac Edery
BACKGROUND: Many diurnal animals exhibit a mid-day 'siesta', generally thought to be an adaptive response aimed at minimizing exposure to heat on warm days, suggesting that in regions with cooler climates mid-day siestas might be a less prominent feature of animal behavior. Drosophila melanogaster exhibits thermal plasticity in its mid-day siesta that is partly governed by the thermosensitive splicing of the 3'-terminal intron (termed dmpi8) from the key circadian clock gene period (per)...
January 23, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/27817175/a-longer-siesta-dn1s-in-control
#10
Wesley A Leigh, Yong Zhang
No abstract text is available yet for this article.
February 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27785516/effect-of-conscious-sedation-vs-general-anesthesia-on-early-neurological-improvement-among-patients-with-ischemic-stroke-undergoing-endovascular-thrombectomy-a-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Silvia Schönenberger, Lorenz Uhlmann, Werner Hacke, Simon Schieber, Sibu Mundiyanapurath, Jan C Purrucker, Simon Nagel, Christina Klose, Johannes Pfaff, Martin Bendszus, Peter A Ringleb, Meinhard Kieser, Markus A Möhlenbruch, Julian Bösel
Importance: Optimal management of sedation and airway during thrombectomy for acute ischemic stroke is controversial due to lack of evidence from randomized trials. Objective: To assess whether conscious sedation is superior to general anesthesia for early neurological improvement among patients receiving stroke thrombectomy. Design, Setting, and Participants: SIESTA (Sedation vs Intubation for Endovascular Stroke Treatment), a single-center, randomized, parallel-group, open-label treatment trial with blinded outcome evaluation conducted at Heidelberg University Hospital in Germany (April 2014-February 2016) included 150 patients with acute ischemic stroke in the anterior circulation, higher National Institutes of Health Stroke Scale (NIHSS) score (>10), and isolated/combined occlusion at any level of the internal carotid or middle cerebral artery...
November 15, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27670625/intense-conductivity-suppression-by-edge-defects-in-zigzag-mos2-and-wse2-nanoribbons-a-density-functional-based-tight-binding-study
#12
F W N Silva, A L M T Costa, Lei Liu, E B Barros
The effects of edge vacancies on the electron transport properties of zigzag MoS2/WSe2 nanoribbons are studied using a density functional theory (DFT)-based tight-binding model with a sp(3)d(5) basis set for the electronic structure calculation and applying the Landauer-Büttiker approach for the electronic transport. Our results show that the presence of a single edge vacancy, with a missing MoS2/WSe2 triplet, is enough to suppress the conductance of the system by almost one half for most energies around the Fermi level...
November 4, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27568798/sleep-is-critical-for-remote-preconditioning-induced-neuroprotection
#13
Allison J Brager, Tao Yang, J Christopher Ehlen, Roger P Simon, Robert Meller, Ketema N Paul
STUDY OBJECTIVES: Episodes of brief limb ischemia (remote preconditioning) in mice induce tolerance to modeled ischemic stroke (focal brain ischemia). Since stroke outcomes are in part dependent on sleep-wake history, we sought to determine if sleep is critical for the neuroprotective effect of limb ischemia. METHODS: EEG/EMG recording electrodes were implanted in mice. After a 24 h baseline recording, limb ischemia was induced by tightening an elastic band around the left quadriceps for 10 minutes followed by 10 minutes of release for two cycles...
November 1, 2016: Sleep
https://www.readbyqxmd.com/read/27479324/circadian-neuron-feedback-controls-the-drosophila-sleep-activity-profile
#14
Fang Guo, Junwei Yu, Hyung Jae Jung, Katharine C Abruzzi, Weifei Luo, Leslie C Griffith, Michael Rosbash
Little is known about the ability of Drosophila circadian neurons to promote sleep. Here we show, using optogenetic manipulation and video recording, that a subset of dorsal clock neurons (DN1s) are potent sleep-promoting cells that release glutamate to directly inhibit key pacemaker neurons. The pacemakers promote morning arousal by activating these DN1s, implying that a late-day feedback circuit drives midday siesta and night-time sleep. To investigate more plastic aspects of the sleep program, we used a calcium assay to monitor and compare the real-time activity of DN1 neurons in freely behaving males and females...
August 18, 2016: Nature
https://www.readbyqxmd.com/read/27290714/-epidemiological-study-on-the-relationship-between-the-siesta-and-blood-pressure
#15
Y M Cao, D Li, K B Li, H Yu, W Xin, D J Miao, Y An
OBJECTIVE: Use epidemiological approaches to investigate the correlation between the siesta and blood pressure. METHOD: From March 1(st,) 2011 to June 30(th) 2013, a total of 950 people were collected from East Jiaozhou Qingdao region using variable sampling methods including stratified method, the entire group method, random and proportional methods. Medical professionals conducted a person-to-person survey, collecting the data and inputting it into computers, after which a database was established using STATA 12...
June 7, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27043260/optimal-vitamin-d3-daily-intake-of-2000iu-inferred-from-modeled-solar-exposure-of-ancestral-humans-in-northern-tanzania
#16
Janusz W Krzyścin, Jakub Guzikowski, Bonawentura Rajewska-Więch
Recently, high serum 25-hydroxyvitamin D concentration (~110nmol/L) was found in the Hadza tribe still keeping ancient hunter-gather life style. This level could serve as optimal vitamin D level that was built during millennia of human evolution. The personal vitamin D3 effective solar exposures of the Hadza adults are estimated using radiative model simulations with input from the satellite observations over lake Eyasi (3.7°S, 35.0°E). The calculations are carried out assuming the Hadza typical clothing habits and specific scenarios of the out-door activity comprising early morning and late afternoon working time in sun and prolonged midday siesta in the shade...
June 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27006424/reply-from-sch%C3%A3-nenberger-et%C3%A2-al-to-the-letter-from-kofke-and-sharma-regarding-sedation-vs-intubation-for-endovascular-stroke-treatment-siesta-a-randomized-monocentric-trial
#17
EDITORIAL
Silvia Schönenberger, Julian Bösel
No abstract text is available yet for this article.
October 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26933098/siesta-trial-is-ga-a-drug-you-get-from-the-hospital-pharmacy
#18
EDITORIAL
W Andrew Kofke, Deepak Sharma
No abstract text is available yet for this article.
August 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26868037/dtrpa1-in-non-circadian-neurons-modulates-temperature-dependent-rhythmic-activity-in-drosophila-melanogaster
#19
Antara Das, Todd C Holmes, Vasu Sheeba
In fruit flies Drosophila melanogaster, environmental cycles of light and temperature are known to influence behavioral rhythms through dedicated sensory receptors. But the thermosensory pathways and molecular receptors by which thermal cycles modulate locomotor activity rhythms remain unclear. Here, we report that neurons expressing warmth-activated ion channel Drosophila Transient Receptor Potential-A1 (dTRPA1) modulate distinct aspects of the rhythmic activity/rest rhythm in a light-dependent manner. Under light/dark (LD) cycles paired with constantly warm ambient conditions, flies deficient in dTRPA1 expression are unable to phase morning and evening activity bouts appropriately...
June 2016: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/26635577/automatic-sleep-spindle-detection-and-genetic-influence-estimation-using-continuous-wavelet-transform
#20
Marek Adamczyk, Lisa Genzel, Martin Dresler, Axel Steiger, Elisabeth Friess
Mounting evidence for the role of sleep spindles in neuroplasticity has led to an increased interest in these non-rapid eye movement (NREM) sleep oscillations. It has been hypothesized that fast and slow spindles might play a different role in memory processing. Here, we present a new sleep spindle detection algorithm utilizing a continuous wavelet transform (CWT) and individual adjustment of slow and fast spindle frequency ranges. Eighteen nap recordings of ten subjects were used for algorithm validation. Our method was compared with both a human scorer and a commercially available SIESTA spindle detector...
2015: Frontiers in Human Neuroscience
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