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Michael M Farag, Nevine S Abd El Malak, Soad A Yehia
The aim of this study was to develop a novel buccal bi-layered chronopatch capable of eliciting pulsatile release pattern of drugs treating diseases with circadian rhythm related manifestation. Zaleplon (ZLP) was used as a model drug intended to induce sleep and to treat middle of night insomnia. The chronopatch was prepared adopting double casting technique. The first layer was composed of a controlled release patch containing ZLP-Precirol melt granules intended to release ZLP in a sustained manner to maintain sleep and to prevent early morning awakening...
March 8, 2018: International Journal of Pharmaceutics
Luc M LeBlanc, Alberto Otero-de-la-Roza, Erin R Johnson
Molecular crystal structure prediction (CSP) requires evaluating differences in lattice energy between candidate crystal structures accurately and efficiently. In this work, we explore and compare several low-cost alternatives to dispersion-corrected density-functional theory (DFT) in the plane-waves/pseudopotential approximation, the most accurate and general approach used in CSP at present. Three types of low-cost methods are considered: DFT with a small basis set of finite-support numerical orbitals (the SIESTA method), dispersion-corrected Gaussian small or minimal-basis-set Hartree-Fock and DFT with additional empirical corrections (HF-3c and PBEh-3c), and self-consistent-charge dispersion-corrected density-functional tight binding (SCC-DFTB3-D3)...
March 2, 2018: Journal of Chemical Theory and Computation
Maria Efthymia Katsa, Anastasios Ioannidis, Sofia Zyga, Maria Tsironi, Paraskevas Koutsovitis, Stylianos Chatzipanagiotou, Demosthenes Panagiotakos, Athanasios Sachlas, Petros Kolovos, Kleopatra Routsi, Anna Maria Pistikou, Dafni Eleni Kougioumtzi Dimoliani, Andrea Paola Rojas Gil
PURPOSE: To investigate the effect of lifestyle habits in childhood Metabolic Syndrome (MTS). DESIGN AND METHODS: Descriptive correlation study with 480 participants (5-12 years old) using a specially designed questionnaire was conducted. Anthropometric and biochemical analyses were performed. RESULTS: Fifteen percent of children exhibited predisposition for MTS. Regarding sleep habits, logistic regression analysis (LRA) showed that hour of sleep -before 22:00- was associated with decreased waist circumference (WC%) (p = ...
February 2, 2018: Journal of Pediatric Nursing
Farshad Yaghouti Niyat, M H Shahrokh Abadi
Despite SIESTA and COMSOL being increasingly used for the simulation of the sensing mechanism in the gas sensors, there are no modeling and simulation reports in literature for detection of NO2 based rGO/SnO2 sensors. In the present study, we model, simulate, and characterize an NO2 based rGO/SnO2 gas sensor using COMSOL by solving the Poisson's equations under associated boundary conditions of mass, heat and electrical transitions. To perform the simulation, we use an exposure model for presenting the required NO2, a heat transfer model to obtain a reaction temperature, and an electrical model to characterize the sensor's response in the presence of the gas...
February 1, 2018: Scientific Reports
Zhichao Zhang, Weihuan Cao, Isaac Edery
Similar to many diurnal animals, Drosophila melanogaster exhibits a mid-day siesta that is more robust as temperature increases, an adaptive response that aims to minimize the deleterious effects from exposure to heat. This temperature-dependent plasticity in mid-day sleep levels is partly based on the thermal sensitive splicing of an intron in the 3' untranslated region (UTR) of the circadian clock gene termed period (per). In this study, we evaluated a possible role for the serine/arginine-rich (SR) splicing factors in the regulation of dmpi8 splicing efficiency and mid-day siesta...
January 30, 2018: Scientific Reports
E N Georgousopoulou, N Naumovski, D D Mellor, S Tyrovolas, S Piscopo, G Valacchi, N Tsakountakis, A Zeimbekis, V Bountziouka, E Gotsis, G Metallinos, D Tyrovola, J Kellett, A Foscolou, J-A Tur, A-L Matalas, C Lionis, E Polychronopoulos, L Sidossis, D Panagiotakos
OBJECTIVES: Several lifestyle parameters including diet, physical activity and sleep were associated in isolation with the presence of Metabolic Syndrome (MetS) in adults, to date there is a paucity of studies which evaluated their combined role aging populations and especially with respect to gender. Therefore, the aim of the present study was to provide a global consideration of the lifestyle factors associated with MetS among elderly individuals. DESIGN: Cross-sectional observational study...
2017: Journal of Nutrition, Health & Aging
Ibuki Ueoka, Hitoshi Kawashima, Atsushi Konishi, Mikio Aoki, Ryo Tanaka, Hideki Yoshida, Toru Maeda, Mamiko Ozaki, Masamitsu Yamaguchi
Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interactions, as well as restricted, stereotyped patterns of behavior and interests. In addition, alterations in circadian sleep-wake rhythm are common in young children with ASD. Mutations in ATP binding cassette subfamily A member 13 (ABCA13) have been recently identified in a monkey that displays behavior associated with ASD. ABCA13, a member of the ABCA family of proteins, is predicted to transport lipid molecules and is expressed in the human trachea, testis, bone marrow, hippocampus, cortex, and other tissues...
February 2018: Experimental Neurology
Johannes A R Pfaff, Silvia Schönenberger, Simon Nagel, Peter A Ringleb, Werner Hacke, Martin Bendszus, Julian Bösel, Markus Alfred Möhlenbruch
Purpose To investigate whether the sedation mode (ie, conscious sedation [CS] vs general anesthesia [GA]) affects the angiographic workflow applied for treatment of endovascular stroke in a post hoc analysis of a recent randomized controlled trial, Sedation versus Intubation for Endovascular Stroke Treatment (SIESTA). Materials and Methods SIESTA was an institutional review board-approved, single-center, prospective, randomized, parallel-group, open-label treatment trial with a blinded end-point evaluation to compare GA with CS for treatment of endovascular stroke in 73 and 77 patients, respectively...
March 2018: Radiology
Sanne Roessingh, Ralf Stanewsky
trpA1 encodes a thermosensitive transient receptor potential channel (TRP channel) that functions in selection of preferred temperatures and noxious heat avoidance. In this review, we discuss the evidence for a role of TRPA1 in the control of rhythmic behaviours in Drosophila melanogaster. Activity levels during the afternoon and rhythmic temperature preference are both regulated by TRPA1. In contrast, TRPA1 is dispensable for temperature synchronisation of circadian clocks. We discuss the neuronal basis of TRPA1-mediated temperature effects on rhythmic behaviours, and conclude that they are mediated by partly overlapping but distinct neuronal circuits...
October 3, 2017: International Journal of Molecular Sciences
J Lopez-Minguez, J J Morosoli, J A Madrid, M Garaulet, J R Ordoñana
Siesta is a relevant aspect of sleep due to its posited relationship with health or cognitive function. However, unlike night-time sleep, studies about daytime-sleep determinants and characteristics are scarce, and the genetic/environmental structure of siesta is still unknown. Our aim was to explore the relative contribution of genetic and environmental factors to variation in sleep-wake rhythm, measured by a continuous assessment of temperature-activity-position (TAP), which allows for diurnal sleep analysis...
September 26, 2017: Scientific Reports
Huibin Kang, Xin Feng, Baorui Zhang, Erkang Guo, Luyao Wang, Zenghui Qian, Peng Liu, Xiaolong Wen, Wenjuan Xu, Youxiang Li, Chuhan Jiang, Zhongxue Wu, Hongbing Zhang, Aihua Liu
BACKGROUND: Previous studies have examined an association between the siesta habit and hypertension, as well as coronary heart disease. However, the relationship between a siesta and the risk of rupture of an intracranial aneurysm (IA) has not yet been established. We aimed to investigate the effects of a siesta on the risk of rupture of IAs. METHODS: We prospectively enrolled consecutive patients diagnosed with IAs at our hospital between January 2016 and December 2016...
2017: Frontiers in Neurology
Yujie Li, Yili Wu, Long Zhai, Tong Wang, Yongye Sun, Dongfeng Zhang
This study aimed to evaluate the associations of nighttime sleep duration and midday napping with risk of depressive symptoms incidence and persistence among middle-aged and older Chinese. Data from China Health and Retirement Longitudinal Study, CHARLS (2011-2013), were analyzed. Depressive symptoms were identified by the 10-item version of the Centre for Epidemiological Studies Depression scale (CESD-10). Multivariate binary logistic regression models were fitted. There were 7156 individuals with CESD-10 scores < 10 and 3896 individuals with CESD-10 scores ≥ 10 at baseline included in this study...
September 18, 2017: Scientific Reports
Janna Mantua, Rebecca M C Spencer
The mid-day nap, sometimes called a siesta, is a ubiquitous occurrence across the lifespan. It is well established that in addition to reducing sleepiness, mid-day naps offer a variety of benefits: memory consolidation, preparation for subsequent learning, executive functioning enhancement, and a boost in emotional stability. These benefits are present even if a sufficient amount of sleep is obtained during the night prior. However, we present a paradox: in spite of these reported benefits of naps, frequent napping has also been associated with numerous negative outcomes (eg, cognitive decline, hypertension, diabetes), particularly in older populations...
September 2017: Sleep Medicine
Abigail E Dove, Brianne L Cook, Zhazira Irgebay, Christopher G Vecsey
Sleep can be altered by an organism's previous experience. For instance, female Drosophila melanogaster experience a post-mating reduction in daytime sleep that is purportedly mediated by sex peptide (SP), one of many seminal fluid proteins (SFPs) transferred from male to female during mating. In the present study, we first characterized this mating effect on sleep more fully, as it had previously only been tested in young flies under 12h light/12h dark conditions. We found that mating reduced sleep equivalently in 3-day-old or 14-day-old females, and could even occur in females who had been mated previously, suggesting that there is not a developmental critical period for the suppression of sleep by mating...
August 26, 2017: Physiology & Behavior
Christa Kistenpfennig, Rudi Grebler, Maite Ogueta, Christiane Hermann-Luibl, Matthias Schlichting, Ralf Stanewsky, Pingkalai R Senthilan, Charlotte Helfrich-Förster
Rhodopsin 7 ( Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000, but its function has remained elusive. We generated an Rh7 null mutant ( Rh7(0)) by P element-mediated mutagenesis and found that an absence of Rh7 had significant effects on fly activity patterns during light-dark (LD) cycles: Rh7(0) mutants exhibited less morning activity and a longer siesta than wild-type controls. Consistent with these results, we found that Rh7 appears to be expressed in a few dorsal clock neurons that have been previously implicated in the control of the siesta...
August 1, 2017: Journal of Biological Rhythms
S Schönenberger, J Pfaff, L Uhlmann, C Klose, S Nagel, P A Ringleb, W Hacke, M Kieser, M Bendszus, M A Möhlenbruch, J Bösel
BACKGROUND AND PURPOSE: Radiologic selection criteria to identify patients likely to benefit from endovascular stroke treatment are still controversial. In this post hoc analysis of the recent randomized Sedation versus Intubation for Endovascular Stroke TreAtment (SIESTA) trial, we aimed to investigate the impact of sedation mode (conscious sedation versus general anesthesia) on the predictive value of collateral status. MATERIALS AND METHODS: Using imaging data from SIESTA, we assessed collateral status with the collateral score of Tan et al and graded it from absent to good collaterals (0-3)...
August 2017: AJNR. American Journal of Neuroradiology
Ekavi N Georgousopoulou, Duane D Mellor, Nenad Naumovski, Evangelos Polychronopoulos, Stefanos Tyrovolas, Suzanne Piscopo, Giuseppe Valacchi, Foteini Anastasiou, Akis Zeimbekis, Vassiliki Bountziouka, Efthimios Gotsis, George Metallinos, Dimitra Tyrovola, Alexandra Foscolou, Josep-Antoni Tur, Antonia-Leda Matalas, Christos Lionis, Labros Sidossis, Demosthenes Panagiotakos
BACKGROUND: Adherence to a Mediterranean dietary pattern is a well-established protective factor against cardiovascular disease (CVD). However, diet quality is only one aspect of the overall healthy lifestyle adopted by Mediterranean populations. The latter has never been evaluated as a multi-factorial composite lifestyle. Thus, the aim of the present study was to provide a broader picture of the Mediterranean lifestyle and its effects on CVD risk, among elderly individuals. METHODS: During 2005-2015, 2,749 older (aged 65-100 years) from 21 Mediterranean islands (MEDIS) and the rural Mani region (Peloponnesus) of Greece were voluntarily enrolled onto the study...
April 2017: Cardiovascular Diagnosis and Therapy
Kunyu Shen, Yeoungjee Cho, Elaine M Pascoe, Carmel M Hawley, Veronica Oliver, Kathryn M Hughes, Richard Baer, Jeremy Frazier, Elizabeth Jarvis, Ken-Soon Tan, Xusheng Liu, Glenda Gobe, David W Johnson
Objectives. To compare the effectiveness of real acupressure versus sham acupressure therapy in improving sleep quality in patients receiving hemodialysis (HD) or hemodiafiltration (HDF). Methods. A multicenter, single-blind, randomized controlled trial was conducted in two Australian dialysis units located in Princess Alexandra Hospital and Logan Hospital, respectively. Forty-two subjects with self-reported poor sleep quality were randomly assigned to real (n = 21) or sham (n = 21) acupressure therapy delivered thrice weekly for four consecutive weeks during routine dialysis sessions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Jesús Villar, Carmen Martín-Rodríguez, Ana M Domínguez-Berrot, Lorena Fernández, Carlos Ferrando, Juan A Soler, Ana M Díaz-Lamas, Elena González-Higueras, Leonor Nogales, Alfonso Ambrós, Demetrio Carriedo, Mónica Hernández, Domingo Martínez, Jesús Blanco, Javier Belda, Dácil Parrilla, Fernando Suárez-Sipmann, Concepción Tarancón, Juan M Mora-Ordoñez, Lluís Blanch, Lina Pérez-Méndez, Rosa L Fernández, Robert M Kacmarek
OBJECTIVES: The driving pressure (plateau pressure minus positive end-expiratory pressure) has been suggested as the major determinant for the beneficial effects of lung-protective ventilation. We tested whether driving pressure was superior to the variables that define it in predicting outcome in patients with acute respiratory distress syndrome. DESIGN: A secondary analysis of existing data from previously reported observational studies. SETTING: A network of ICUs...
May 2017: Critical Care Medicine
Martin Bendszus
No abstract text is available yet for this article.
March 2017: Clinical Neuroradiology
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