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https://www.readbyqxmd.com/read/27817175/a-longer-siesta-dn1s-in-control
#1
Wesley A Leigh, Yong Zhang
No abstract text is available yet for this article.
November 5, 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/27785516/effect-of-conscious-sedation-vs-general-anesthesia-on-early-neurological-improvement-among-patients-with-ischemic-stroke-undergoing-endovascular-thrombectomy-a-randomized-clinical-trial
#2
Silvia Schönenberger, Lorenz Uhlmann, Werner Hacke, Simon Schieber, Sibu Mundiyanapurath, Jan C Purrucker, Simon Nagel, Christina Klose, Johannes Pfaff, Martin Bendszus, Peter A Ringleb, Meinhard Kieser, Markus A Möhlenbruch, Julian Bösel
Importance: Optimal management of sedation and airway during thrombectomy for acute ischemic stroke is controversial due to lack of evidence from randomized trials. Objective: To assess whether conscious sedation is superior to general anesthesia for early neurological improvement among patients receiving stroke thrombectomy. Design, Setting, and Participants: SIESTA (Sedation vs Intubation for Endovascular Stroke Treatment), a single-center, randomized, parallel-group, open-label treatment trial with blinded outcome evaluation conducted at Heidelberg University Hospital in Germany (April 2014-February 2016) included 150 patients with acute ischemic stroke in the anterior circulation, higher National Institutes of Health Stroke Scale (NIHSS) score (>10), and isolated/combined occlusion at any level of the internal carotid or middle cerebral artery...
November 15, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27670625/intense-conductivity-suppression-by-edge-defects-in-zigzag-mos2-and-wse2-nanoribbons-a-density-functional-based-tight-binding-study
#3
F W N Silva, A L M T Costa, Lei Liu, E B Barros
The effects of edge vacancies on the electron transport properties of zigzag MoS2/WSe2 nanoribbons are studied using a density functional theory (DFT)-based tight-binding model with a sp(3)d(5) basis set for the electronic structure calculation and applying the Landauer-Büttiker approach for the electronic transport. Our results show that the presence of a single edge vacancy, with a missing MoS2/WSe2 triplet, is enough to suppress the conductance of the system by almost one half for most energies around the Fermi level...
November 4, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27568798/sleep-is-critical-for-remote-preconditioning-induced-neuroprotection
#4
Allison J Brager, Tao Yang, J Christopher Ehlen, Roger P Simon, Robert Meller, Ketema N Paul
STUDY OBJECTIVES: Episodes of brief limb ischemia (remote preconditioning) in mice induce tolerance to modeled ischemic stroke (focal brain ischemia). Since stroke outcomes are in part dependent on sleep-wake history, we sought to determine if sleep is critical for the neuroprotective effect of limb ischemia. METHODS: EEG/EMG recording electrodes were implanted in mice. After a 24 h baseline recording, limb ischemia was induced by tightening an elastic band around the left quadriceps for 10 minutes followed by 10 minutes of release for two cycles...
November 1, 2016: Sleep
https://www.readbyqxmd.com/read/27479324/circadian-neuron-feedback-controls-the-drosophila-sleep-activity-profile
#5
Fang Guo, Junwei Yu, Hyung Jae Jung, Katharine C Abruzzi, Weifei Luo, Leslie C Griffith, Michael Rosbash
Little is known about the ability of Drosophila circadian neurons to promote sleep. Here we show, using optogenetic manipulation and video recording, that a subset of dorsal clock neurons (DN1s) are potent sleep-promoting cells that release glutamate to directly inhibit key pacemaker neurons. The pacemakers promote morning arousal by activating these DN1s, implying that a late-day feedback circuit drives midday siesta and night-time sleep. To investigate more plastic aspects of the sleep program, we used a calcium assay to monitor and compare the real-time activity of DN1 neurons in freely behaving males and females...
August 18, 2016: Nature
https://www.readbyqxmd.com/read/27290714/-epidemiological-study-on-the-relationship-between-the-siesta-and-blood-pressure
#6
Y M Cao, D Li, K B Li, H Yu, W Xin, D J Miao, Y An
OBJECTIVE: Use epidemiological approaches to investigate the correlation between the siesta and blood pressure. METHOD: From March 1(st,) 2011 to June 30(th) 2013, a total of 950 people were collected from East Jiaozhou Qingdao region using variable sampling methods including stratified method, the entire group method, random and proportional methods. Medical professionals conducted a person-to-person survey, collecting the data and inputting it into computers, after which a database was established using STATA 12...
June 7, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27043260/optimal-vitamin-d3-daily-intake-of-2000iu-inferred-from-modeled-solar-exposure-of-ancestral-humans-in-northern-tanzania
#7
Janusz W Krzyścin, Jakub Guzikowski, Bonawentura Rajewska-Więch
Recently, high serum 25-hydroxyvitamin D concentration (~110nmol/L) was found in the Hadza tribe still keeping ancient hunter-gather life style. This level could serve as optimal vitamin D level that was built during millennia of human evolution. The personal vitamin D3 effective solar exposures of the Hadza adults are estimated using radiative model simulations with input from the satellite observations over lake Eyasi (3.7°S, 35.0°E). The calculations are carried out assuming the Hadza typical clothing habits and specific scenarios of the out-door activity comprising early morning and late afternoon working time in sun and prolonged midday siesta in the shade...
June 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27006424/reply-from-sch%C3%A3-nenberger-et%C3%A2-al-to-the-letter-from-kofke-and-sharma-regarding-sedation-vs-intubation-for-endovascular-stroke-treatment-siesta-a-randomized-monocentric-trial
#8
EDITORIAL
Silvia Schönenberger, Julian Bösel
No abstract text is available yet for this article.
October 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26933098/siesta-trial-is-ga-a-drug-you-get-from-the-hospital-pharmacy
#9
EDITORIAL
W Andrew Kofke, Deepak Sharma
No abstract text is available yet for this article.
August 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26868037/dtrpa1-in-non-circadian-neurons-modulates-temperature-dependent-rhythmic-activity-in-drosophila-melanogaster
#10
Antara Das, Todd C Holmes, Vasu Sheeba
In fruit flies Drosophila melanogaster, environmental cycles of light and temperature are known to influence behavioral rhythms through dedicated sensory receptors. But the thermosensory pathways and molecular receptors by which thermal cycles modulate locomotor activity rhythms remain unclear. Here, we report that neurons expressing warmth-activated ion channel Drosophila Transient Receptor Potential-A1 (dTRPA1) modulate distinct aspects of the rhythmic activity/rest rhythm in a light-dependent manner. Under light/dark (LD) cycles paired with constantly warm ambient conditions, flies deficient in dTRPA1 expression are unable to phase morning and evening activity bouts appropriately...
June 2016: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/26635577/automatic-sleep-spindle-detection-and-genetic-influence-estimation-using-continuous-wavelet-transform
#11
Marek Adamczyk, Lisa Genzel, Martin Dresler, Axel Steiger, Elisabeth Friess
Mounting evidence for the role of sleep spindles in neuroplasticity has led to an increased interest in these non-rapid eye movement (NREM) sleep oscillations. It has been hypothesized that fast and slow spindles might play a different role in memory processing. Here, we present a new sleep spindle detection algorithm utilizing a continuous wavelet transform (CWT) and individual adjustment of slow and fast spindle frequency ranges. Eighteen nap recordings of ten subjects were used for algorithm validation. Our method was compared with both a human scorer and a commercially available SIESTA spindle detector...
2015: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/26486360/the-sexually-dimorphic-behaviour-of-adult-drosophila-suzukii-elevated-female-locomotor-activity-and-loss-of-siesta-is-a-post-mating-response
#12
Calum T J Ferguson, Tara L O'Neill, Neil Audsley, R Elwyn Isaac
The polyphagous Drosophila suzukii is a highly invasive species that causes extensive damage to a wide range of berry and stone fruit crops. A better understanding of its biology and especially its behaviour will aid the development of new control strategies. We investigated the locomotor behaviour of D. suzukii in a semi-natural environment resembling a typical summer in northern England and show that adult female D. suzukii are at least 4-fold more active during daylight hours than adult males. This result was reproduced in several laboratory environments and was shown to be a robust feature of mated, but not virgin, female flies...
December 2015: Journal of Experimental Biology
https://www.readbyqxmd.com/read/26472080/density-functional-theory-for-steady-state-nonequilibrium-molecular-junctions
#13
Shuanglong Liu, Argo Nurbawono, Chun Zhang
We present a density functional theory (DFT) for steady-state nonequilibrium quantum systems such as molecular junctions under a finite bias. Based on the steady-state nonequilibrium statistics that maps nonequilibrium to an effective equilibrium, we show that ground-state DFT (GS-DFT) is not applicable in this case and two densities, the total electron density and the density of current-carrying electrons, are needed to uniquely determine the properties of the corresponding nonequilibrium system. A self-consistent mean-field approach based on two densities is then derived...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26459465/loss-of-drosophila-melanogaster-trpa1-function-affects-siesta-behavior-but-not-synchronization-to-temperature-cycles
#14
Sanne Roessingh, Werner Wolfgang, Ralf Stanewsky
To maintain synchrony with the environment, circadian clocks use a wide range of cycling sensory cues that provide input to the clock (zeitgebers), including environmental temperature cycles (TCs). There is some knowledge about which clock neuronal groups are important for temperature synchronization, but we currently lack knowledge on the temperature receptors and their signaling pathways that feed temperature information to the (neuronal) clock. Since TRPA1 is a well-known thermosensor that functions in a range of temperature-related behaviors, and it is potentially expressed in clock neurons, we set out to test the putative role of TRPA1 in temperature synchronization of the circadian clock...
December 2015: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/26446213/maternal-ube3a-loss-disrupts-sleep-homeostasis-but-leaves-circadian-rhythmicity-largely-intact
#15
J Christopher Ehlen, Kelly A Jones, Lennisha Pinckney, Cloe L Gray, Susan Burette, Richard J Weinberg, Jennifer A Evans, Allison J Brager, Mark J Zylka, Ketema N Paul, Benjamin D Philpot, Jason P DeBruyne
UNLABELLED: Individuals with Angelman syndrome (AS) suffer sleep disturbances that severely impair quality of life. Whether these disturbances arise from sleep or circadian clock dysfunction is currently unknown. Here, we explored the mechanistic basis for these sleep disorders in a mouse model of Angelman syndrome (Ube3a(m-/p+) mice). Genetic deletion of the maternal Ube3a allele practically eliminates UBE3A protein from the brain of Ube3a(m-/p+) mice, because the paternal allele is epigenetically silenced in most neurons...
October 7, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26356787/theoretical-study-of-the-infrared-frequencies-of-crystalline-methyl-acetate-under-interstellar-medium-conditions
#16
Radhika Narayanan, Kensuke Inomata, Geetha Gopakumar, Bhalamurugan Sivaraman, Yasunari Zempo, Masahiko Hada
Identification of methyl acetate in the interstellar medium (ISM) and its spectroscopic studies have prompted us to investigate the structure of crystalline methyl acetate using numerical calculations. Here, we present a theoretical study of the structure of crystalline methyl acetate and its isotopologues and compare the calculated infrared (IR) spectra with the available experimental data. The optimized structure and vibrational properties were calculated using SIESTA software at 0 K. In the optimization process, the Perdew-Burke-Ernzerhof functional and conjugate gradient methods were used with double zeta polarization basis functions...
January 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/26266758/the-concept-of-qailulah-midday-napping-from-neuroscientific-and-islamic-perspectives
#17
Mohd Amzari Tumiran, Noor Naemah Abdul Rahman, Rohaida Mohd Saat, Nurul Kabir, Mohd Yakub Zulkifli, Durriyyah Sharifah Hasan Adli
Napping/siesta during the day is a phenomenon, which is widely practised in the world. However, the timing, frequency, and duration may vary. The basis of napping is also diverse, but it is mainly done for improvement in alertness and general well-being. Neuroscience reveals that midday napping improves memory, enhances alertness, boosts wakefulness and performance, and recovers certain qualities of lost night sleep. Interestingly, Islam, the religion of the Muslims, advocates midday napping primarily because it was a practice preferred by Prophet Muhammad (pbuh)...
August 13, 2015: Journal of Religion and Health
https://www.readbyqxmd.com/read/26217711/systematic-pseudopotentials-from-reference-eigenvalue-sets-for-dft-calculations-pseudopotential-files
#18
Pablo Rivero, Víctor Manuel García-Suárez, David Pereñiguez, Kainen Utt, Yurong Yang, Laurent Bellaiche, Kyungwha Park, Jaime Ferrer, Salvador Barraza-Lopez
We present in this article a pseudopotential (PP) database for DFT calculations in the context of the SIESTA code [1-3]. Comprehensive optimized PPs in two formats (psf files and input files for ATM program) are provided for 20 chemical elements for LDA and GGA exchange-correlation potentials. Our data represents a validated database of PPs for SIESTA DFT calculations. Extensive transferability tests guarantee the usefulness of these PPs.
June 2015: Data in Brief
https://www.readbyqxmd.com/read/26134622/siesta-is-associated-with-reduced-systolic-blood-pressure-level-and-decreased-prevalence-of-hypertension-in-older-adults
#19
LETTER
M Cai, Y Huang, X Sun, Y He, C Sun
No abstract text is available yet for this article.
March 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/26124142/drosophila-circadian-rhythms-in-seminatural-environments-summer-afternoon-component-is-not-an-artifact-and-requires-trpa1-channels
#20
Edward W Green, Emma K O'Callaghan, Celia N Hansen, Stefano Bastianello, Supriya Bhutani, Stefano Vanin, James Douglas Armstrong, Rodolfo Costa, Charalambos P Kyriacou
Under standard laboratory conditions of rectangular light/dark cycles and constant warm temperature, Drosophila melanogaster show bursts of morning (M) and evening (E) locomotor activity and a "siesta" in the middle of the day. These M and E components have been critical for developing the neuronal dual oscillator model in which clock gene expression in key cells generates the circadian phenotype. However, under natural European summer conditions of cycling temperature and light intensity, an additional prominent afternoon (A) component that replaces the siesta is observed...
July 14, 2015: Proceedings of the National Academy of Sciences of the United States of America
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