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Yanyan Qi, Xiangyan Yao, Beibei Zhang, Xianhui DU
The aim of the present study was to compare the recovery of sufentanil and remifentanil anesthesia by target-controlled infusion (TCI) in elderly patients with laparoscopic-assisted radical resection of colorectal cancer. The effect of anesthesia on patient stress response and cellular immune function was also observed. Elderly patients (n=192) who underwent laparoscopic radical resection of colorectal cancer between July 2014 and October 2015 were randomly divided into the sufentanil and remifentanil groups (n=96 per group)...
May 2016: Oncology Letters
Cheng-Hua Zhang, Wei-Qing Ma, Yun-Li Yang, Hui-Ming Wang, Fa-Tuan Dong, Zhang-Xiang Huang
BACKGROUND: To determine the median effective concentration of sufentanil as an analgesic during wake-up tests after sevoflurane anesthesia during surgery for adolescent idiopathic scoliosis (AIS). METHODS: This is a randomised controlled trial. Sixty patients aged 13-18 years scheduled for AIS surgery were randomized into six groups of 10 patients each to receive target effect-site concentrations of sufentanil of 0.19, 0.1809, 0.1723, 0.1641, 0.1563, and 0.1489 ng/ml (target concentration ratio, 1...
2015: BMC Anesthesiology
T I Saari, H Ihmsen, J Mell, K Fröhlich, J Fechner, J Schüttler, C Jeleazcov
BACKGROUND: Our objective was to evaluate the effect of intensive care treatment on the protein binding of sufentanil and hydromorphone in cardiac surgery patients during postoperative analgesia using a target-controlled infusion (TCI) and patient-controlled analgesia (PCA). METHODS: Fifty adult patients were enrolled in this prospective randomized study; of which, 49 completed the study (age range 40-81 yr). Sufentanil was administered as an analgesic intraoperatively, and hydromorphone was dosed after operation with TCI and PCA until 8 a...
October 2014: British Journal of Anaesthesia
Roshdi R Al-Metwalli
OBJECTIVE: The objective of this study is to determine the optimal effect-site concentration (Ce) of sufentanil for satisfactory insertion of laryngeal mask airway (LMA) when administered with a target-controlled infusion (TCI) of propofol at 4.0 μg/mL. MATERIALS AND METHODS: A total of 25 adult patients scheduled for minor elective surgery were enrolled in this study. All patients received induction with a combination of propofol and sufentanil TCI. The TCI of sufentanil was started at a target Ce of 0...
April 2014: Saudi Journal of Anaesthesia
B Rozec, H Floch, P Berlivet, P Michel, Y Blanloeil
BACKGROUND: For decades thiopental has been considered as the hypnotic drug of choice for intracranial surgery. However, total intravenous anesthesia performed with thiopental is associated with delayed recovery, whereas early post-operative neurological evaluation is critical. For this reason, target controlled infusion (TCI) of propofol is increasingly used for maintenance of anesthesia. However, a thiopental TCI has never been assessed for this purpose. We tested the hypothesis that a thiopental TCI provides an acceptable way to achieve early recovery compared to a propofol TCI during supratentorial surgery...
July 2014: Minerva Anestesiologica
Lingyang Chen, Mingcang Wang, Haifei Xiang, Xianju Lin, Donghang Cao, Liyue Ye
This study was to investigate the feasibility and efficiency of by target-controlled infusion (TCI) for analgesia and sedation during burn dressing change, and to predict the effect-site concentration of sufentanil. Eighty burn patients were randomly and evenly divided into four groups according to target sufentanil effect-site concentration (0.2, 0.3, 0.4 and 0.5 ng/ml). The sufentanil-propofol TCI was carried out during dressing changes. The effect-site concentration of propofol was maintained at 1.2 μg/ml...
May 2014: Burns: Journal of the International Society for Burn Injuries
Cheng-Hua Zhang, Wei-Qing Ma, Yun-Li Yang, Fa-Tuan Dong, Hui-Ming Wang, Hui-Ming Wei
STUDY OBJECTIVE: To investigate the effect of the intraoperative wake-up test on sevoflurane-sufentanil anesthesia for adolescent idiopathic scoliosis (AIS) surgery. DESIGN: Randomized, double-blind, parallel trial. SETTING: Operating room. PATIENTS: 30 ASA physical status 1 patients, aged 13 to 20 years, scheduled for AIS surgery. INTERVENTIONS: Patients were randomized to two groups: Group W patients received sevoflurane-sufentanil combined anesthesia and underwent the intraoperative wake-up test; Group NW received sevoflurane-sufentanil combined anesthesia without the wake-up test...
June 2013: Journal of Clinical Anesthesia
Naser Yeganeh, Bahman Roshani, Hossein Latifi, Afshin Almasi
BACKGROUND: Maintaining blood pressure (BP) and heart rate (HR) after laryngoscopy and tracheal intubation has always been a concern in injured patients. Opioids can attenuate or stop an increase in these two parameters if administered with proper doses or targets in target-controlled infusion (TCI). Remifentanil and sufentanil are widely used for this purpose because their cardiac side effects are low and, especially in traumatic patients, they are tolerated well. A comparison of the benefits and limitations of these two opioids in TCI is much needed...
July 2013: Journal of Injury & Violence Research
Li-Guo Hu, Jian-Hui Pan, Juan Li, Fang Kang, Ling Jiang
The current study aimed to observe the effects of sufentanil and remifentanil combined with propofol in target-controlled infusion (TCI) on perioperative stress reaction in elderly patients. A total of 80 elderly patients requiring general anesthesia were recruited. They were divided into four groups (each n=20) according to different target concentrations of remifentanil and sufentanil. These target concentrations were: 4 ng/ml remifentanil + 0.2 ng/ml sufentanil for group I; 3 ng/ml remifentanil + 0.3 ng/ml sufentanil for group II; 2 ng/ml remifentanil + 0...
March 2013: Experimental and Therapeutic Medicine
C Jeleazcov, T I Saari, H Ihmsen, J Schüttler, J Fechner
BACKGROUND: Target controlled infusion (TCI) with sufentanil is usually performed using the Gepts model, which was derived from patients undergoing general surgery. It is, however, known that pharmacokinetics of sufentanil can be changed during cardiopulmonary bypass (CPB). We tested whether TCI during coronary artery bypass surgery with CPB produces constant total, unbound sufentanil concentration-time course or both. METHODS: After IRB approval, written informed consent was obtained from 38 male patients (48-74 yr) undergoing coronary artery bypass surgery...
November 2012: British Journal of Anaesthesia
Xu Lili, Hu Zhiyong, Shen Jianjun
BACKGROUND: Both over- and undercorrection can occur in up to 10-15% of strabismus surgeries. Use of adjustable suture technique and an intraoperative awake test may decrease the incidence of over- or undercorrection. In this study, we investigated the ability to provide optimal conditions for intraoperative awake strabismus suture adjustment in children by means of target-controlled infusions (TCI) of propofol and remifentanil propofol compared with propofol and sufentanil. METHODS: Forty-six ASA I-II patients undergoing strabismus surgery with intraoperative awakening were randomly assigned to anesthesia by TCI of propofol + sufentanil group (group SF) or propofol + remifentanil spontaneous breathing...
December 2012: Paediatric Anaesthesia
Lili Liang, Shanhe Wan, Jinfang Xiao, Jiajie Zhang, Miaoning Gu
A rapid, selective and highly sensitive ultra-performance liquid-chromatography mass-spectrometry (UPLC-MS/MS) method has been developed and validated for the determination of sufentanil in human plasma. Sufentanil was separated on an ACQUITY™ UPLC BEH C(18) column (50 mm × 2.1 mm, ID 1.7 μm) and analyzed in positive-ion (PI) electrospray-ionization (ESI) mode. The mobile phase (MP) consisted of acetonitrile:water (45:55, v/v) under isocratic conditions at a flow rate of 0.2 ml/min. Sufentanil and internal-standard (IS) fentanyl were eluted at 1...
March 25, 2011: Journal of Pharmaceutical and Biomedical Analysis
Javad Bidgoli, Sophie Delesalle, Stefan G De Hert, Eric Reiles, Philippe J Van der Linden
BACKGROUND AND OBJECTIVE: This prospective, randomised double-blind study compared the effects of target control infusion (TCI) of sufentanil and remifentanil on the quality of recovery and post-operative pain control in morbidly obese patients undergoing laparoscopic gastroplasty. METHODS: Following institutional Ethics Committee approval and written informed consent, 100 morbidly obese patients were randomised to receive either TCI sufentanil (0.3 ng ml⁻¹; S-group; N = 50) or TCI remifentanil (3 ng ml⁻¹; R-group; N = 50) in combination with desflurane (O₂/air mixture: FiO₂, 50%)...
February 2011: European Journal of Anaesthesiology
S M Jung, C W Yang, J-Y Oh, C K Cho, P S Kang, Y S Lim, S-J Jeong, H U Kwon
BACKGROUND: this study was to estimate the predicted effect-site concentration of propofol administered by a target-controlled infusion (TCI) for maintenance of anesthesia based on the bispectral (BIS) index as a measure of hypnosis in laparoscopic surgery. METHOD: one-hundred and sixty unpremedicated patients undergoing gynecologic laparoscopy were assigned randomly to receive one of the target effect-site concentrations of propofol 2.0, 2.5, 3.0, 3.5 and 4.0 microg/ml during TCI with propofol and sufentanil...
January 2011: Acta Anaesthesiologica Scandinavica
Yan Zhao, Li-ping Zhang, Xin-min Wu, Jian-yu Jiang, Jing-li Duan, Yong-fang Hu, Min Li, Wei Liu, Xiao-yan Sheng, Cheng Ni, Mao Xu, Xiang-yang Guo
BACKGROUND: Sufentanil target controlled infusion (TCI) provides stable analgesia, better hemodynamic control than a bolus injection of intravenous anesthetics, anticipated recovery and improved quality of anesthesia during perioperative period. This study evaluated the accuracy and feasibility of TCI system for sufentanil at high concentrations in Chinese surgical patients. METHODS: Twelve low risk adult patients undergoing elective surgery under general anesthesia were included in this study...
October 20, 2009: Chinese Medical Journal
Yan Zhao, Jing-li Duan, Xin-min Wu, Jian-yu Jiang, Wei Lu, Li-ping Zhang, Jun Wang, Xiu-li Meng, Chuan-ya Xu, Dong-lin Jia, Wei Liu, Xiao-yan Sheng
BACKGROUND: Sufentanil is a suitable choice for target-controlled infusion (TCI) because of its shorter context-sensitive half-time. The current study was to estimate the pharmacokinetics of sufentanil TCI in Chinese patients using the two-stage analysis. METHODS: Twelve adult patients with American Society of Anesthesiologists (ASA) physical status I or II undergoing elective surgery under general anesthesia were included. Anesthesia was induced with propofol, rocuronium and sufentanil administered by TCI lasting for 30 minutes, with target effect-site concentration of sufentanil 4 or 6 ng/ml...
September 5, 2009: Chinese Medical Journal
Fernando Squeff Nora
BACKGROUND AND OBJECTIVES: Total intravenous anesthesia (TIVA) has seen several developments since it was first used. Since the synthesis of the first intravenous anesthetics, with the introduction of barbiturates (1921) and thiopental (1934), TIVA has evolved until the development of TIVA with target-controlled infusion pumps (TCI). The first pharmacokinetic model for the use of TCI was described by Schwilden in 1981. From that moment on, it was demonstrated that it is possible to maintain the desired plasma concentration of a drug using an infusion pump managed by a computer...
March 2008: Revista Brasileira de Anestesiologia
Yan Zhao, Xin-min Wu, Jing-li Duan, Xiao-yan Sheng, Wei Liu, Wei Lu, Li-ping Zhang, Chuan-ya Xu
BACKGROUND: Target-controlled infusion (TCI) has been recently developed and successfully implemented in clinical practice. This study was conducted to determine the pharmacokinetics of TCI administered sufentanil in Chinese surgical patients. METHODS: The pharmacokinetics of sufentanil was investigated in 12 adult patients, aged 23-76 years, scheduled for prolonged surgery under general anesthesia. Anesthetic induction was carried out with propofol, rocuronium and TCI administered sufentanil aiming for target effect-site concentration of sufentanil 4 or 6 ng/ml...
February 5, 2009: Chinese Medical Journal
L Tremelot, A Restoux, C Paugam-Burtz, S Dahmani, L Massias, C Peuch, J Belghiti, J Mantz
OBJECTIVE: The anhepatic phase of orthotopic liver transplantation (OLT) is associated with significant changes in pharmacokinetics. The aim of this study was to compare the influence of this phase on propofol target concentrations during BIS guided target controlled infusion (TCI). STUDY DESIGN: Prospective study. PATIENTS AND METHODS: Eight patients aged 25 to 65 years, Child-Pugh status A-B scheduled for OLT were prospectively included...
December 2008: Annales Françaises D'anesthèsie et de Rèanimation
Predrag D Stevanovic, Guenka Petrova, Branislava Miljkovic, Radisav Scepanovic, Radoslav Perunovic, Dragos Stojanovic, Janja Dobrasinovic
BACKGROUND: Laparoscopic surgery is widely recognized as a well-tolerated and effective method for cholecystectomy. It is also considered cost saving because it has been associated with a decreased hospital length of stay. Variables that might lead to increased costs in laparoscopic surgery are the technique and drugs used in anesthesia. OBJECTIVE: The goal of this study was to compare the costs of 2 anesthetic techniques used in laparoscopic cholecystectomy (LC)--balanced versus IV anesthesia--from the standpoint of an outpatient surgical department, with a time horizon of 1 year...
September 2008: Clinical Therapeutics
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