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https://www.readbyqxmd.com/read/29453831/evaluation-of-a-recombinant-multiepitope-antigen-for-diagnosis-of-hepatitis-c-virus-a-lower-cost-alternative-for-antigen-production
#1
Ronaldo Luis Thomasini, Hortencia Gisele Amaro Souza, Oscar Bruna-Romero, Antonio Helvecio Totola, Neiva Sellan Lopes Gonçales, Cristiano Xavier Lima, Mauro Martins Teixeira
BACKGROUND: The most of the hepatitis C-infected patients remain undiagnosed until they develop severe liver damage or submitted for serological screening. OBJECTIVE: To evaluate a recombinant multiepitope protein for detection of IgG anti-hepatitis C virus. METHOD: A synthetic gene was cloned, expressed in Escherichia coli, and the recombinant protein was purified. Human serum panel consisted of 88 positives (20 HCV genotyped) and 376 negatives for hepatitis C, 6 positives for human acquired immunodeficiency virus, 6 syphilis positives, 6 hepatitis B positives were tested by IgG antihepatitis C virus using the protein by enzyme-linked immunosorbent assay...
February 17, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29453698/corneal-collagen-cross-linking-for-the-management-of-mycotic-keratitis
#2
Elif Erdem, Ibrahim Inan Harbiyeli, Hazal Boral, Macit Ilkit, Meltem Yagmur, Reha Ersoz
PURPOSE: To evaluate the efficiency of corneal collagen cross-linking (CXL) in addition to topical voriconazole in cases with mycotic keratitis. DESIGN: Retrospective case series in a tertiary university hospital. PARTICIPANTS: CXL was performed on 13 patients with mycotic keratitis who presented poor or no response to topical voriconazole treatment. METHODS: The clinical features, symptoms, treatment results and complications were recorded retrospectively...
February 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29453691/effect-of-phosphorylation-and-single-nucleotide-polymorphisms-on-caspase-substrates-processing
#3
Sonu Kumar, Piotr Cieplak
Posttranslational modifications that involve either reversible covalent modification of proteins or irreversible proteolysis are central to the regulation of key cellular mechanisms, including apoptosis, cell-cycle regulation and signal transduction. There is mounting evidence suggesting cross-talk between proteases and kinases. For instance: caspases, a class of proteases involved in programmed cell death-apoptosis, cleave a large set of various types of proteins. Simultaneously, kinases restrict caspase activity by phosphorylating their protein substrates in the vicinity of cleavage site...
February 16, 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29453514/prevalence-and-determinants-of-vitamin-d-deficiency-among-the-overweight-and-obese-singaporeans-seeking-weight-management-including-bariatric-surgery-a-relationship-with-bone-health
#4
Marc Weijie Ong, Chun Hai Tan, Anton Kui Sing Cheng
PURPOSE: Low vitamin D status is prevalent worldwide and has been linked to a variety of pathologies including obesity in adults. The severity of vitamin D deficiency amongst the overweight and obese Singaporeans is not well documented. The purpose of this prospective observational study was to assess the prevalence and determinants of vitamin D deficiency in a multi-ethnic Asian population referred for weight management, including those seeking bariatric surgery. MATERIALS AND METHODS: This was a cross-sectional study conducted among 111 consecutive subjects referred to a single institution weight management service in Singapore...
February 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29453295/socioeconomic-religious-spiritual-and-health-factors-associated-with-symptoms-of-common-mental-disorders-a-cross-sectional-secondary-analysis-of-data-from-bhutan-s-gross-national-happiness-study-2015
#5
Gyambo Sithey, Mu Li, Li Ming Wen, Patrick J Kelly, Kelly Clarke
OBJECTIVE: Common mental disorders (CMDs) are a major cause of the global burden of disease. Bhutan was the first country in the world to focus on happiness as a state policy; however, little is known about the prevalence and risk factors of CMDs in this setting. We aim to identify socioeconomic, religious, spiritual and health factors associated with symptoms of CMDs. DESIGN AND SETTING: We used data from Bhutan's 2015 Gross National Happiness (GNH) Survey, a multistage, cross-sectional nationwide household survey...
February 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453112/pattern-and-determinants-of-self-reported-enacted-stigma-among-rural-dwellers-living-with-epilepsy-attending-a-tertiary-health-facility-in-enugu-state-nigeria
#6
Birinus A Ezeala-Adikaibe, Justin U Achor, Eddy Aneke, Uchenna Ijoma, Obinna D Onodugo, Casmir Orjioke, Chinwe Onyekonwu, Oluchi Ekenze
PURPOSE: Epilepsy related stigma is a barrier to recovery and has been linked to a broad range of psychosocial consequences and has the potential to influence the provision of care to people with epilepsy. Understanding the determinants of enacted stigma in epilepsy is relevant in the understanding of the burden of epilepsy in Nigeria. METHOD: Using a semi-structured questionnaire, a cross-sectional descriptive study was conducted among rural dwellers receiving treatment for epilepsy in a tertiary referral specialist hospital in Enugu, south east Nigeria...
February 10, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29453010/qzone-use-and-depression-among-chinese-adolescents-a-moderated-mediation-model
#7
Geng-Feng Niu, Yi-Jun Luo, Xiao-Jun Sun, Zong-Kui Zhou, Feng Yu, Shen-Long Yang, Liang Zhao
BACKGROUND: Social networking sites (SNSs), which provide abundant social comparison opportunities, are ubiquitous around the world, especially among adolescents. In China, Qzone stands out as the most popular SNS. Due to the opportunity it provides for meticulous self-presentation, SNS may give the impression that others are doing better, which is detrimental to individuals' well-being. Based on social comparison theory, the current study aimed to investigate the association between Chinese adolescents' SNS (Qzone) use and depression, as well as the mediating role of negative social comparison and the moderating role of self-esteem...
January 31, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29452946/time-responsive-osteogenic-niche-of-stem-cells-a-sequentially-triggered-dual-peptide-loaded-alginate-hybrid-system-for-promoting-cell-activity-and-osteo-differentiation
#8
Zuyuan Luo, Siqi Zhang, Jijia Pan, Rui Shi, Hao Liu, Yalin Lyu, Xiao Han, Yan Li, Yue Yang, Zhixiu Xu, Yi Sui, En Luo, Yuanyuan Zhang, Shicheng Wei
The efficacy of stem cell-based bone tissue engineering has been hampered by cell death and limited fate control. A smart cell culture system with the capability of sequentially delivering multiple factors in specific growth stages, like the mechanism of the natural extracellular matrix modulating tissue formation, is attractive for enhancing cell activity and controlling cell fate. Here, a bone forming peptide-1 (BFP-1)-laden mesoporous silica nanoparticles (pep@MSNs) incorporated adhesion peptide, containing the arginine-glycine-aspartic acid (RGD) domain, modified alginate hydrogel (RA) system (pep@MSNs-RA) was developed to promote the activity and stimulate osteo-differentiation of human mesenchymal stem cells (hMSCs) in sequence...
February 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29452569/up-regulation-of-sftpb-expression-and-attenuation-of-acute-lung-injury-by-pulmonary-epithelial-cell-specific-nampt-knockdown
#9
Guangliang Bi, Lei Wu, Peixin Huang, Shamima Islam, Daniel P Heruth, Li Qin Zhang, Ding-You Li, Venkatesh Sampath, Weimin Huang, Brett A Simon, Ronald Blaine Easley, Shui Qing Ye
Although a deficiency of surfactant protein B (SFTPB) has been associated with lung injury, SFTPB expression has not yet been linked with nicotinamide phosphoribosyltransferase (NAMPT), a potential biomarker of acute lung injury (ALI). The effects of Nampt in the pulmonary epithelial cell on both SFTPB expression and lung inflammation were investigated in a LPS-induced ALI mouse model. Pulmonary epithelial cell-specific knockdown of Nampt gene expression, achieved by the crossing of Nampt gene exon 2 floxed mice with mice expressing epithelial-specific transgene Cre or by the use of epithelial-specific expression of anti-Nampt antibody cDNA, significantly attenuated LPS-induced ALI...
February 8, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29452389/parity-associated-with-telomere-length-among-us-reproductive-age-women
#10
A Z Pollack, K Rivers, K A Ahrens
STUDY QUESTION: Is telomere length related to parity among a nationally representative sample of US reproductive age women? SUMMARY ANSWER: History of live birth was associated with shorter telomere length. WHAT IS KNOWN ALREADY: Shorter telomeres have been linked with a range of chronic health conditions and mortality and parity has been associated with health indicators. However, there is a lack of research on how parity relates to telomere length...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29452130/magnetic-combined-cross-linked-enzyme-aggregates-combi-cleas-for-cofactor-regeneration-in-the-synthesis-of-chiral-alcohol
#11
Erzheng Su, Yang Meng, Chenxi Ning, Xiaoqiang Ma, Senwen Deng
Magnetic Fe 3 O 4 nanoparticles were prepared and embedded into the Combi-CLEAs to produce the magnetic Combi-CLEAs in this work. The process for magnetic Combi-CLEAs preparation was optimized, and its properties were investigated. The optimum temperature, thermal stability and optimum pH of magnetic Combi-CLEAs were similar to those of Combi-CLEAs. The catalytic performance of magnetic Combi-CLEAs was tested with the biosynthesis of (S)-ethyl 4-chloro-3-hydroxybutyrate ((S)-CHBE). Magnetic Combi-CLEAs could tolerate higher substrate concentration in the biphasic system...
February 13, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29451986/treatment-of-striae-distensae-an-evidence-based-approach
#12
Emily Forbat, Firas Al-Niaimi
Striae distensae (SD), otherwise known as "stretchmarks," are a common presenting complaint, particularly in young healthy women. SD are hypothesized to form in a patient when the cross-linked collagen is "overstretched" and rupture of this collagen matrix causes the striae. Thus, many treatments work by increasing collagen synthesis. This review critically appraises the evidence to date for the treatment of SD, including both energy-based devices and topical treatments.
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29451741/non-invasive-optical-method-for-real-time-assessment-of-intracorneal-riboflavin-concentration-and-efficacy-of-corneal-cross-linking
#13
Giuseppe Lombardo, Valentina Villari, Norberto Liborio Micali, Nancy Leone, Cristina Labate, Maria Penelope De Santo, Marco Lombardo
Keratoconus is the primary cause of corneal transplantation in young adults worldwide. Riboflavin/UV-A corneal cross-linking may effectively halt the progression of keratoconus if an adequate amount of riboflavin enriches the corneal stroma and is photo-oxidated by UV-A light for generating additional cross-linking bonds between stromal proteins and strengthening the biomechanics of the weakened cornea. Here we reported a UV-A theranostic prototype device for performing corneal cross-linking with the ability to assess corneal intrastromal concentration of riboflavin and to estimate treatment efficacy in real time...
February 16, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29451460/early-childhood-conduct-problems-predict-economic-and-political-discontent-in-adulthood-evidence-from-two-large-longitudinal-uk-cohorts
#14
Gary J Lewis
Longstanding interest has been directed toward the etiology of sociopolitical attitudes. Personality traits have been posited as antecedents; however, most work addressing such links has been limited to cross-sectional study designs. The current study used data from two large (both Ns > 8,700), longitudinal cohorts of individuals from the United Kingdom who were parent-assessed on a measure of temperament (assessing anxiety, conduct problems, and hyperactivity) at age 5 or 7 years and on a range of sociopolitical attitudes at age 30 or 33 years...
February 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29451358/electronic-structure-characterisation-of-cross-linked-sulfur-polymers
#15
Ute Cappel, Peng Liu, Fredrik Johansson, Bertrand Philippe, Erika Giangrisostomi, Ruslan Ovsyannikov, Andreas Lindblad, Lars Kloo, James Gardner, Håkan Rensmo
Cross-linked polymers of elemental sulfur are of potential interest for electronic applications as they enable facile thin film processing of an abundant and cheap starting material. In this paper, we characterize the electronic structure of a cross-linked sulfur / diisopropenyl benzene (DIB) polymer by a combination of soft and hard X-ray photoelectron spectroscopy. Two different approaches for enhancing the conductivity of the polymer are compared: the addition of selenium in the polymer synthesis and the addition of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) during film preparation...
February 16, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29451033/control-release-of-mitochondria-targeted-antioxidant-by-injectable-self-assembling-peptide-hydrogel-ameliorated-persistent-mitochondrial-dysfunction-and-inflammation-after-acute-kidney-injury
#16
Meng Zhao, Yijie Zhou, Shuyun Liu, Lan Li, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu
Persistent mitochondrial injury occurs after acute kidney injury (AKI) and mitochondria-targeted antioxidant Mito-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) (MT) has shown benefits for AKI, but its efficiency is limited by short half-life and side effect in vivo. Self-assembling peptide (SAP) hydrogel is a robust platform for drug delivery. This study aims to develop an SAP-based carrier to slow release MT for enhancing its long-term therapeutic potency on AKI. The KLD with aspartic acid (KLDD) was designed...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29450926/macroscopic-adhesion-of-thermoreversible-abc-triblock-copolymer-based-hydrogels-via-boronic-acid-sugar-complexation
#17
Ryota Tamate, Kotomi Takahashi, Takeshi Ueki, Aya Mizutani Akimoto, Ryo Yoshida
Two complementary thermoreversible ABC triblock copolymers containing either phenylboronic acids with low pK a values or galactosyl groups in the hydrophilic B blocks are synthesized by sequential reversible addition-fragmentation chain transfer polymerization and subsequent modification of the functional groups. Both ABC triblock copolymers undergo reversible sol-to-gel transitions upon temperature change and form physically cross-linked hydrogels under physiological conditions. Furthermore, the spontaneous adhesion of these thermoreversible hydrogels via the formation of boronic esters between the phenylboronic acid and galactosyl groups under physiological conditions is realized for the first time...
February 16, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29450805/ph-responsive-cap-co-poly-methacrylic-acid-based-hydrogel-as-an-efficient-platform-for-controlled-gastrointestinal-delivery-fabrication-characterization-in-vitro-and-in-vivo-toxicity-evaluation
#18
Syed Ahmed Shah, Muhammad Sohail, Muhammad Usman Minhas, Nisar-Ur-Rehman, Shahzeb Khan, Zahid Hussain, Mudassir, Arshad Mahmood, Mubeen Kousar, Asif Mahmood
Cellulose acetate phthalate-based pH-responsive hydrogel was synthesized for fabrication of polymeric matrix tablets for gastro-protective delivery of loxoprofen sodium. Cellulose acetate phthalate (CAP) was cross-linked with methacrylic acid (MAA) using free radical polymerization technique. Fourier transform infrared (FTIR) spectra confirmed the formation of cross-linked structure of CAP-co-poly(methacrylic acid). Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the thermal stability of polymeric networks, and scanning electron microscopy (SEM) and energy-dispersive X-ray spectrum (EDS) images unveiled that the prepared formulations were porous in nature and thus the developed formulations had shown better diffusibility...
February 15, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29450447/interplay-among-psychopathologic-variables-personal-resources-context-related-factors-and-real-life-functioning-in-individuals-with-schizophrenia-a-network-analysis
#19
Silvana Galderisi, Paola Rucci, Brian Kirkpatrick, Armida Mucci, Dino Gibertoni, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Gregory P Strauss, Eugenio Aguglia, Antonello Bellomo, Martino Belvederi Murri, Paola Bucci, Bernardo Carpiniello, Anna Comparelli, Alessandro Cuomo, Domenico De Berardis, Liliana Dell'Osso, Fabio Di Fabio, Barbara Gelao, Carlo Marchesi, Palmiero Monteleone, Cristiana Montemagni, Giulia Orsenigo, Francesca Pacitti, Rita Roncone, Paolo Santonastaso, Alberto Siracusano, Annarita Vignapiano, Antonio Vita, Patrizia Zeppegno, Mario Maj
Importance: Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people with schizophrenia. To date, this is the first study using network analysis to investigate the associations among cognitive, psychopathologic, and psychosocial variables in a large sample of community-dwelling individuals with schizophrenia. Objective: To assess the interplay among psychopathologic variables, cognitive dysfunctions, functional capacity, personal resources, perceived stigma, and real-life functioning in individuals with schizophrenia, using a data-driven approach...
February 14, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29449815/combinatorial-codes-and-labeled-lines-how-insects-use-olfactory-cues-to-find-and-judge-food-mates-and-oviposition-sites-in-complex-environments
#20
REVIEW
Alexander Haverkamp, Bill S Hansson, Markus Knaden
Insects, including those which provide vital ecosystems services as well as those which are devastating pests or disease vectors, locate their resources mainly based on olfaction. Understanding insect olfaction not only from a neurobiological but also from an ecological perspective is therefore crucial to balance insect control and conservation. However, among all sensory stimuli olfaction is particularly hard to grasp. Our chemical environment is made up of thousands of different compounds, which might again be detected by our nose in multiple ways...
2018: Frontiers in Physiology
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