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https://www.readbyqxmd.com/read/28222359/disgust-proneness-predicts-obsessive-compulsive-disorder-symptom-severity-in-a-clinical-sample-of-youth-distinctions-from-negative-affect
#1
Bunmi O Olatunji, Chad Ebesutani, Jingu Kim, Bradley C Riemann, David M Jacobi
BACKGROUND: Although studies have linked disgust proneness to the etiology and maintenance of obsessive-compulsive disorder (OCD) in adults, there remains a paucity of research examining the specificity of this association among youth. METHOD: The present study employed structural equation modeling to examine the association between disgust proneness, negative affect, and OCD symptom severity in a clinical sample of youth admitted to a residential treatment facility (N =471)...
February 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28222201/linkage-and-mapping-of-quantitative-trait-loci-associated-with-angular-leaf-spot-and-powdery-mildew-resistance-in-common-beans
#2
Denis Bassi, Boris Briñez, Juliana Santa Rosa, Paula Rodrigues Oblessuc, Caléo Panhoca de Almeida, Stella Maris Nucci, Larissa Chariel Domingos da Silva, Alisson Fernando Chiorato, Rosana Pereira Vianello, Luis Eduardo Aranha Camargo, Matthew Wohlgemuth Blair, Luciana Lasry Benchimol-Reis
Angular leaf spot (ALS) and powdery mildew (PWM) are two important fungi diseases causing significant yield losses in common beans. In this study, a new genetic linkage map was constructed using single sequence repeats (SSRs) and single nucleotide polymorphisms (SNPs), in a segregating population derived from the AND 277 x SEA 5 cross, with 105 recombinant inbred lines. Phenotypic evaluations were performed in the greenhouse to identify quantitative trait loci (QTLs) associated with resistance by means of the composite interval mapping analysis...
February 20, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28222130/dengue-virus-antibody-database-systematically-linking-serotype-specificity-with-epitope-mapping-in-dengue-virus
#3
Sidhartha Chaudhury, Gregory D Gromowski, Daniel R Ripoll, Ilja V Khavrutskii, Valmik Desai, Anders Wallqvist
BACKGROUND: A majority infections caused by dengue virus (DENV) are asymptomatic, but a higher incidence of severe illness, such as dengue hemorrhagic fever, is associated with secondary infections, suggesting that pre-existing immunity plays a central role in dengue pathogenesis. Primary infections are typically associated with a largely serotype-specific antibody response, while secondary infections show a shift to a broadly cross-reactive antibody response. METHODS/PRINCIPAL FINDINGS: We hypothesized that the basis for the shift in serotype-specificity between primary and secondary infections can be found in a change in the antibody fine-specificity...
February 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28222087/repetitive-negative-thinking-the-link-between-caregiver-burden-and-depressive-symptoms
#4
Amanda Mitchell, Patrick Pössel
PURPOSE/OBJECTIVES: To explore whether repetitive negative thinking (RNT) mediates the pathway between subscales of caregiver burden and depressive symptoms. 
. DESIGN: Cross-sectional pilot study. 
. SETTING: Bone marrow unit at the University of Louisville Hospital in Kentucky and caregiver support organizations in Louisville.
. SAMPLE: 49 current cancer caregivers who were primarily spouses or partners of individuals with lymphoma or leukemia and provided care for a median of 30 hours each week for 12 months...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28222039/building-multi-country-collaboration-on-watershed-management-lessons-on-linking-environment-and-public-health-from-the-western-balkans
#5
Maryann R Cairns, Clayton E Cox, Jose Zambrana, Joseph Flotemersch, Alexis Lan, Anna Phillips, Gordana Kozhuharova, Mihallaq Qirjo, Marta Szigeti Bonifert, Lek Kadeli
Community-based watershed resilience programs that bridge public health and environmental outcomes often require cross-boundary, multi-country collaboration. The CRESSIDA project, led by the Regional Environmental Center for Central and Eastern Europe (REC) and supported by the US Environmental Protection Agency (EPA), forwards a resilience-focused approach for Western Balkan communities in the Drini and Drina river watersheds with the goal of safeguarding public health and the environment. The initial phases of this project give a contextualized example of how to advance resilience-driven environmental health goals in Western Balkan communities, and experience within the region has garnered several theme areas that require focus in order to promote a holistic watershed management program...
February 21, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28221913/an-immunoassay-for-quantification-of-contamination-by-raw-meat-juice-on-food-contact-surfaces
#6
Fur-Chi Chen, Sandria Godwin, Edgar Chambers
Raw chicken products often are contaminated with Salmonella and Campylobacter , which can be transmitted from packages to contact surfaces. Raw meat juices from these packages also provide potential media for cross-contamination. There are limited quantitative data on the levels of consumer exposure to raw meat juice during shopping for and handling of chicken products. An exposure assessment is needed to quantify the levels of transmission and to assess the risk. An enzyme-linked immunosorbent assay (ELISA) was developed and validated for quantitative detection of raw meat juice on hands and various food contact surfaces...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221870/bovine-leukemia-virus-and-mycobacterium-avium-subsp-paratuberculosis-are-not-associated-with-shiga-toxin-producing-escherichia-coli-shedding-in-cattle
#7
Cristina Venegas-Vargas, Shannon D Manning, Paul M Coussens, Jonathan A Roussey, Paul Bartlett, Daniel Grooms
Bovine leukemia virus (BLV) is a retrovirus that causes enzootic bovine leukosis in cattle, and Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne's disease in cattle. Both diseases are chronic in nature and can lead to the disruption of normal immunological or physiological processes. Cattle are the major reservoir of Shiga toxin-producing Escherichia coli (STEC), a cause of foodborne illness in humans. We tested the hypothesis that cattle infected with BLV or MAP are more likely to shed STEC...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221772/desleucyl-oritavancin-with-a-damaged-d-ala-d-ala-binding-site-inhibits-the-transpeptidation-step-of-cell-wall-biosynthesis-in-whole-cells-of-staphylococcus-aureus
#8
Sung Joon Kim, Manmilan Singh, Shasad Sharif, Jacob Schaefer
We have used solid-state NMR to characterize the exact nature of the dual mode of action of oritavancin in preventing cell-wall assembly in Staphylococcus aureu. Measurements performed on whole cells labeled selectively in vivo have established that des-N-methylleucyl-N-4-(4-fluorophenyl)benzyl-chloroeremomycin, an Edman degradation product of [19F]oritavancin, which has a damaged D-Ala-D-Ala binding aglycon, is a potent inhibitor of the transpeptidase activity of cell-wall biosynthesis. The desleucyl-drug binds to partially cross-linked peptidoglycan by a cleft formed between the drug aglycon and its biphenyl hydrophobic sidechain...
February 21, 2017: Biochemistry
https://www.readbyqxmd.com/read/28220890/clinical-investigation-of-the-posterior-scleral-contraction-to-treat-macular-traction-maculopathy-in-highly-myopic-eyes
#9
An-Peng Pan, Ting Wan, Shuang-Qian Zhu, Liang Dong, An-Quan Xue
Myopic traction maculopathy (MTM) can cause vision disabilities in highly myopic eyes. This retrospective case series investigated the clinical outcomes of posterior scleral contraction (PSC) using genipin-cross-linked sclera as the material to treat MTM in highly myopic eyes. In total, 32 eyes from 29 highly myopic patients who underwent PSC for MTM were recruited. The changes in best-corrected visual acuity (BCVA) and axial length were evaluated, macular reattachment and macular hole (MH) closure was assessed by optical coherence tomography, and complications were evaluated...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220551/association-between-sleep-duration-fat-mass-lean-mass-and-obesity-in-korean-adults-the-fourth-and-fifth-korea-national-health-and-nutrition-examination-surveys
#10
Kyuwoong Kim, Doosup Shin, Go-Un Jung, Donghoon Lee, Sang Min Park
This study investigated the association between sleep duration, fat mass, lean mass and obesity. Participants of this cross-sectional study were 16 905 adults included into the 4th and 5th Korea National Health and Nutrition Examination Surveys. Sleep duration was assessed by self-reported survey and categorized into ≤ 5, 6, 7, 8 and ≥ 9 h per day. The group reporting 7 h of sleep per day (comprised of those sleeping 7-8 h per day) was used as the reference group. Body composition was measured by dual X-ray absorptiometry (DEXA)...
February 21, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28220537/immobilization-of-horseradish-peroxidase-on-zno-nanowires-macroporous-sio2-composites-for-the-complete-decolorization-of-anthraquinone-dyes
#11
Huaiyan Sun, Xinyu Jin, Feng Jiang, Ruifeng Zhang
A Zinc Oxide (ZnO) nanowires/ macroporous Silicon dioxide (SiO2 ) composite was used as support to immobilize horseradish peroxidase (HRP) simply by in-situ cross-linking method. As cross-linker was adsorbed on the surface of ZnO nanowires, the cross-linked HRP was quite different from the traditional cross-linking enzyme aggregates (CLEAs) on both structure and catalytic performance. Among three epoxy compounds diethylene glycol diglycidyl ether (DDE) was the best cross-linker, with which the loading amount of HRP with pI of 5...
February 21, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28220243/work-stress-family-stress-and-asthma-a-cross-sectional-study-among-women-in-china
#12
Adrian Loerbroks, Hui Ding, Wei Han, Hong Wang, Jiang-Ping Wu, Liu Yang, Peter Angerer, Jian Li
PURPOSE: Research addressing links of work stress or family stress with asthma is constrained by (1) inconsistent evidence, (2) failure to consider the combined exposure to work stress and family stress, and (3) its primary focus on Western study populations. We aimed to address these knowledge gaps. METHODS: We used cross-sectional data collected in 2015 among 7816 women from five professional groups in five Chinese cities. Work stress was measured by the 10-item effort-reward imbalance (ERI) questionnaire...
February 20, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28220210/applicability-of-in-vitro-in-vivo-translation-of-cathepsin-k-inhibition-from-animal-species-to-human-with-the-use-of-free-drug-hypothesis
#13
Bennett Ma, Bin Luo, Danielle H Euler, Tara E Cusick, Gregg Wesolowski, Helmut Glantschnig, Le T Duong, Yangsi Ou, Steven S Carroll, Laura S Lubbers
The correlation of in vitro inhibition of cathepsin K (CatK) activity and in vivo suppression of collagen I biomarkers was examined with three selective CatK inhibitors to explore the potential translatability from animal species to human. These inhibitors exhibited good in vitro potencies toward recombinant CatK enzymes across species, with IC50 values ranging from 0.20 to 6.1 nM. In vivo studies were conducted in animal species following multiple-day dosing of the CatK inhibitors to achieve steady-state plasma drug concentration-time profiles...
February 20, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28219688/mesoporous-phenylalanine-ammonia-lyase-microspheres-with-improved-stability-through-calcium-carbonate-templating
#14
Jiandong Cui, Yamin Zhao, Zhilei Tan, Cheng Zhong, Peipei Han, Shiru Jia
Cross-linked enzyme aggregates (CLEAs) have recently emerged as a promising method for enzyme immobilization due to its simplicity and low cost. However, a lack of good size and morphological control over the as-prepared CLEAs has limited their practical applications in some cases. Here, monodisperse spherical CLEAs of phenylalanine ammonia lyase (PAL microspheres) were prepared based on CaCO3 microtemplates. The preparation procedure involves filling porous CaCO3 microtemplates with the protein by salt precipitation, glutaraldehyde crosslinking, and dissolution of the microtemplates...
February 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28219472/immunodiagnosis-of-paramphistomosis-using-monoclonal-antibody-based-sandwich-elisa-for-detection-of-paramphistomum-gracile-circulating-16-kda-antigen
#15
Panat Anuracpreeda, Kullanid Tepsupornkul, Runglawan Chawengkirttikul
In this study, we have produced a monoclonal antibody (MoAb) against 16 kDa antigen of Paramphistomum gracile (16 kDaAgPg), and developed an accurate sandwich enzyme-linked immunosorbent assay (sandwich ELISA) for the detection of circulating 16 kDaAg in the serum and fecal samples from cattle naturally infected with P. gracile. MoAb 1D10 was immobilized on a microtitre plate, and the antigen in the samples was captured and detected with biotinylated rabbit anti-16 kDaAgPg antibody. The lower detection limit of sandwich ELISA was 3·5 pg mL-1, and no cross-reaction with other parasite antigens was evaluated...
February 21, 2017: Parasitology
https://www.readbyqxmd.com/read/28219439/rnas-competing-for-micrornas-mutually-influence-their-fluctuations-in-a-highly-non-linear-microrna-dependent-manner-in-single-cells
#16
Carla Bosia, Francesco Sgrò, Laura Conti, Carlo Baldassi, Davide Brusa, Federica Cavallo, Ferdinando Di Cunto, Emilia Turco, Andrea Pagnani, Riccardo Zecchina
BACKGROUND: Distinct RNA species may compete for binding to microRNAs (miRNAs). This competition creates an indirect interaction between miRNA targets, which behave as miRNA sponges and eventually influence each other's expression levels. Theoretical predictions suggest that not only the mean expression levels of targets but also the fluctuations around the means are coupled through miRNAs. This may result in striking effects on a broad range of cellular processes, such as cell differentiation and proliferation...
February 20, 2017: Genome Biology
https://www.readbyqxmd.com/read/28219334/assessing-the-predictive-power-of-psychological-empowerment-and-health-literacy-for-older-patients-participation-in-health-care-a-cross-sectional-population-based-study
#17
Gabriele Sak, Fabia Rothenfluh, Peter J Schulz
BACKGROUND: Research has confirmed a positive link between patient involvement in decision-making and improvements in health outcomes. The objective of this study was to examine the roles of psychological empowerment and health literacy on the elderly's willingness to engage in treatment decisions. METHODS: A self-administered questionnaire was completed by a randomly selected sample of Swiss adults aged 65-80 years old (N = 826). Multivariate logistic regression was applied to determine the contribution of health literacy, psychological empowerment, and trust in physician on participants' preference to be active, collaborative or passive in decision-making...
February 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28219071/is-periodontal-disease-associated-with-alzheimer-s-disease-a-systematic-review-with-meta-analysis
#18
Yago Leira, Clara Domínguez, Juan Seoane, Juan Seoane-Romero, Juan Manuel Pías-Peleteiro, Bahi Takkouche, Juan Blanco, José Manuel Aldrey
BACKGROUND: In the last decade, several observational studies have suggested that there exists an association between periodontal disease (PD) and Alzheimer's disease (AD). The aim of this systematic review was to investigate whether or not this link exists. SUMMARY: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guideline for systematic review was used and registered at PROSPERO (CRD42016035377). The search strategy included using electronic databases and by hand searching articles published up to January 2016...
February 21, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28218731/a-single-use-in-vitro-biosensor-for-the-detection-of-t-tau-protein-a-biomarker-of-neuro-degenerative-disorders-in-pbs-and-human-serum-using-differential-pulse-voltammetry-dpv
#19
Yifan Dai, Alireza Molazemhosseini, Chung Chiun Liu
A single-use, in vitro biosensor for the detection of T-Tau protein in phosphate-buffer saline (PBS) and undiluted human serum was designed, manufactured, and tested. Differential pulse voltammetry (DPV) served as the transduction mechanism. This biosensor consisted of three electrodes: working, counter, and reference electrodes fabricated on a PET sheet. Both working and counter electrodes were thin gold film, 10 nm in thickness. Laser ablation technique was used to define the size and structure of the biosensor...
February 19, 2017: Biosensors
https://www.readbyqxmd.com/read/28218671/human-scfvs-that-counteract-bioactivities-of-staphylococcus-aureus-tsst-1
#20
Thunchanok Rukkawattanakul, Nitat Sookrung, Watee Seesuay, Nattawat Onlamoon, Pornphan Diraphat, Wanpen Chaicumpa, Nitaya Indrawattana
Some Staphylococcus aureus isolates produced toxic shock syndrome toxin-1 (TSST-1) which is a pyrogenic toxin superantigen (PTSAg). The toxin activates a large fraction of peripheral blood T lymphocytes causing the cells to proliferate and release massive amounts of pro-inflammatory cytokines leading to a life-threatening multisystem disorder: toxic shock syndrome (TSS). PTSAg-mediated-T cell stimulation circumvents the conventional antigenic peptide presentation to T cell receptor (TCR) by the antigen-presenting cell (APC)...
February 17, 2017: Toxins
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