keyword
MENU ▼
Read by QxMD icon Read
search

Cross linking

keyword
https://www.readbyqxmd.com/read/28545063/financial-distress-in-patients-with-advanced-cancer
#1
Cécile Barbaret, Christelle Brosse, Wadih Rhondali, Murielle Ruer, Léa Monsarrat, Patrick Michaud, Anne Marie Schott, Marvin Delgado-Guay, Eduardo Bruera, Stéphane Sanchez, Marilène Filbet
PURPOSE: We examined the frequency and severity of financial distress (FD) and its association with quality of life (QOL) and symptoms among patients with advanced cancer in France. DESIGN: In this cross-sectional study, 143 patients with advanced cancer were enrolled. QOL was assessed using the Functional Assessment of Cancer General (FACT-G) and symptoms assessed using Edmonton Assessment System (ESAS) and Hospital Anxiety and Depression Scale (HADS). FD was assessed using a self-rated numeric scale from 0 to 10...
2017: PloS One
https://www.readbyqxmd.com/read/28544848/decomposition-of-phenolic-impregnated-carbon-ablator-pica-as-a-function-of-temperature-and-heating-rate
#2
Brody Bessire, Timothy K Minton
Material response models for phenolic-based thermal protection systems (TPSs) for atmospheric entry are limited by the lack of knowledge of the nonequilibrium processes that may govern the decomposition pathways of phenolic resin at heating rates up to tens of degrees Celsius per second. We have investigated the pyrolysis of phenolic impregnated carbon ablator (PICA) by measuring the molar yields of the volatile decomposition products as a function of temperature at four nominal heating rates of 3.1, 6.1, 12...
May 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28544647/dual-cross-linked-biofunctional-and-self-healing-networks-to-generate-user-defined-modular-gradient-hydrogel-constructs
#3
Zhao Wei, Daniel M Lewis, Yu Xu, Sharon Gerecht
Gradient hydrogels have been developed to mimic the spatiotemporal differences of multiple gradient cues in tissues. Current approaches used to generate such hydrogels are restricted to a single gradient shape and distribution. Here, a hydrogel is designed that includes two chemical cross-linking networks, biofunctional, and self-healing networks, enabling the customizable formation of modular gradient hydrogel construct with various gradient distributions and flexible shapes. The biofunctional networks are formed via Michael addition between the acrylates of oxidized acrylated hyaluronic acid (OAHA) and the dithiol of matrix metalloproteinase (MMP)-sensitive cross-linker and RGD peptides...
May 23, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28544388/healing-effect-of-controlled-anti-electromigration-on-conventional-and-high-tc-superconducting-nanowires
#4
Xavier D A Baumans, Joseph Lombardo, Jérémy Brisbois, Gorky Shaw, Vyacheslav S Zharinov, Ge He, Heshan Yu, Jie Yuan, Beiyi Zhu, Kui Jin, Roman B G Kramer, Joris Van de Vondel, Alejandro V Silhanek
The electromigration process has the potential capability to move atoms one by one when properly controlled. It is therefore an appealing tool to tune the cross section of monoatomic compounds with ultimate resolution or, in the case of polyatomic compounds, to change the stoichiometry with the same atomic precision. As demonstrated here, a combination of electromigration and anti-electromigration can be used to reversibly displace atoms with a high degree of control. This enables a fine adjustment of the superconducting properties of Al weak links, whereas in Nb the diffusion of atoms leads to a more irreversible process...
May 19, 2017: Small
https://www.readbyqxmd.com/read/28544124/secondary-structure-driven-self-assembly-of-reactive-polypept-o-ides-controlling-size-shape-and-function-of-core-cross-linked-nanostructures
#5
Kristina Klinker, Olga Schäfer, David Huesmann, Tobias Bauer, Leon Capelôa, Lydia Braun, Natascha Stergiou, Meike Schinnerer, Anjaneyulu Dirisala, Kanjiro Miyata, Kensuke Osada, Horacio Cabral, Kazunori Kataoka, Matthias Barz
Achieving precise control over morphology and function of polymeric nanoparticles during self-assembly remains a challenge in material as well as bio-medical sciences, especially when all these properties can be controlled independently. Herein, we report on nanostructures derived from amphiphilic block copolypept(o)ides by secondary structure directed self-assembly, presenting a strategy to adjust core polarity separately from particle preparation in a bio-reversible fashion. The peptide-inherent process of secondary structure-formation allows for the synthesis of spherical and worm-like core cross-linked architectures from the same block copolymer, introducing a simple yet powerful approach to versatile peptide-based nanoparticles...
May 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28543553/enhanced-acquired-antibodies-to-a-chimeric-plasmodium-falciparum-antigen-ub05-09-is-associated-with-protective-immunity-against-malaria
#6
Dinga Jerome Nyhalah, Gamua Stanley Dobgima, Vincent PrydeKehdingha Titanji
It has been shown that covalently linking two antigens could enhance the immunogenicity of the chimeric construct. To prioritise such a chimera for malaria vaccine development it is necessary to demonstrate that naturally acquired antibodies against the chimera are associated with protection from malaria. Here we probe the ability of a chimeric construct of UB05 and UB09 antigens (UB05-09) to better differentiate between acquired immune protection and susceptibility to malaria. In a cross-sectional study, recombinant UB05-09 chimera and the constituent antigens were used to probe for specific antibodies in the plasma from children and adults resident in a malaria endemic zone, using the enzyme-linked immunosorbent assay (ELISA)...
May 24, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28542682/applicant-perspectives-on-the-otolaryngology-residency-application-process
#7
Matthew Ward, Christian Pingree, Adrienne M Laury, Sarah N Bowe
Importance: It has been nearly 25 years since medical students were queried regarding their perspectives on otolaryngology-head and neck surgery (OHNS) residency selection. Understanding this viewpoint is critical to improving the current application process. Objective: To evaluate the perceptions of 2016 OHNS residency applicants regarding the application process and offer suggestions for reform. Design, Setting, and Participants: In this cross-sectional study of anonymous online survey data, a 14-question survey was designed based on resources obtained from a computerized PubMed, Ovid, and GoogleScholar database search of the English language from January 1, 1990, through December 31, 2015, was conducted using the following search terms: (medical student OR applicant) AND (application OR match) AND otolaryngology...
May 25, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28542539/a-leishmania-secretion-system-for-the-expression-of-major-ampullate-spidroin-mimics
#8
Todd A Lyda, Elizabeth L Wagner, Andre X Bourg, Congyue Peng, Golnaz Najaf Tomaraei, Delphine Dean, Marian S Kennedy, William R Marcotte
Spider major ampullate silk fibers have been shown to display a unique combination of relatively high fracture strength and toughness compared to other fibers and show potential for tissue engineering scaffolds. While it is not possible to mass produce native spider silks, the potential ability to produce fibers from recombinant spider silk fibers could allow for an increased innovation rate within tissue engineering and regenerative medicine. In this pilot study, we improved upon a prior fabrication route by both changing the expression host and additives to the fiber pulling precursor solution to improve the performance of fibers...
2017: PloS One
https://www.readbyqxmd.com/read/28542382/uv-b-induced-fibrillization-of-crystallin-protein-mixtures
#9
Sibel Cetinel, Valentyna Semenchenko, Jae-Young Cho, Mehdi Ghaffari Sharaf, Karim F Damji, Larry D Unsworth, Carlo Montemagno
Environmental factors, mainly oxidative stress and exposure to sunlight, induce the oxidation, cross-linking, cleavage, and deamination of crystallin proteins, resulting in their aggregation and, ultimately, cataract formation. Various denaturants have been used to initiate the aggregation of crystallin proteins in vitro. All of these regimens, however, are obviously far from replicating conditions that exist in vivo that lead to cataract formation. In fact, it is our supposition that only UV-B radiation may mimic the observed in vivo cause of crystallin alteration leading to cataract formation...
2017: PloS One
https://www.readbyqxmd.com/read/28542227/health-beliefs-of-school-age-rural-children-in-podoconiosis-affected-families-a-qualitative-study-in-southern-ethiopia
#10
Abebayehu Tora, Getnet Tadele, Abraham Aseffa, Colleen M McBride, Gail Davey
BACKGROUND: Several studies have suggested investigation of health beliefs in children to be an important pre-condition for primary prevention of disease. However, little effort has been made to understand these in the context of podoconiosis. This study therefore aimed to explore the health beliefs of school-age rural children in podoconiosis-affected families. METHODOLOGY/PRINCIPAL FINDINGS: A cross sectional qualitative study was conducted in March 2016 in Wolaita Zone, Southern Ethiopia...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28540726/sorption-and-release-of-natural-phenolic-antioxidants-in-different-cyclodextrin-polymers
#11
M García-Padial, María Cristina Martínez-Ohárriz, José Ramón Isasi, A Zornoza
The sorption and release of tyrosol and caffeic acid, two biophenolic antioxidants with known health benefits, in different insoluble cyclodextrin polymers has been studied. Cyclodextrin polymers were synthesized by cross-linking β-cyclodextrin or 50:50 w/w nominal mixtures of α- and β-cyclodextrin using either epichlorohydrin (EP) or toluene-2,4-diisocyanate (TDI) as crosslinking agents. An analogous sucrose polymer was prepared using EP as crosslinking reagent. Freundlich isotherms and isosteric heats of sorption for tyrosol and caffeic acid in the insoluble β-cyclodextrin polymer crosslinked with epichlorohydrin at 50 °C were obtained and discussed...
May 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28540626/cross-sectional-prevalence-of-pancreatic-cystic-lesions-in-patients-with-acromegaly-a-single-center-experience
#12
Yukiko Odake, Hidenori Fukuoka, Masaaki Yamamoto, Yoshifumi Arisaka, Junya Konishi, Kenichi Yoshida, Ryusaku Matsumoto, Hironori Bando, Kentaro Suda, Hitoshi Nishizawa, Genzo Iguchi, Shozo Yamada, Wataru Ogawa, Yutaka Takahashi
PURPOSE: Acromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported that GNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study...
May 24, 2017: Pituitary
https://www.readbyqxmd.com/read/28540578/-complications-and-postoperative-therapeutic-strategies-in-cross-linking
#13
REVIEW
M Kohlhaas
CLINICAL ISSUE: The reduced corneal mechanical stability in keratoconus and similar collagen diseases can lead to a progressive and irregular corneal shape and decrease of visual acuity. DIAGNOSTICS: A progression of keratectatic diseases can be shown with corneal topography. TREATMENT: Keratoconus can be treated by photo-oxidative cross-linking of the corneal collagen. In order to achieve a high absorption of irradiation energy in the cornea, riboflavin at a concentration of 0...
May 24, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28540381/lipoic-acid-based-core-cross-linked-micelles-for-multivalent-platforms-design-synthesis-and-application-in-bio-imaging-and-drug-delivery
#14
Jingsheng Huang, Fang Wu, Yunlong Yu, Haolong Huang, Shiyong Zhang, Jingsong You
Natural lipoic acid derived small-molecule amphiphiles self-assemble into micelles in water. The presence of numerous disulfides accumulated in the core makes the micelles readily cross-linked to achieve the establishment of core cross-linked micelles (CCMs). Thanks to the inherent biocompatibility, the resulting lipoic acid based CCMs (LA-CCMs) are good multivalent platforms for biomedical applications.
May 25, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28540048/medication-self-management-skills-and-cognitive-impairment-in-older-adults-hospitalized-for-heart-failure-a-cross-sectional-study
#15
Erik H Howell, Alpana Senapati, Eileen Hsich, Eiran Z Gorodeski
BACKGROUND: Cognitive impairment is highly prevalent among older adults (aged ≥65 years) hospitalized for heart failure and has been associated with poor outcomes. Poor medication self-management skills have been associated with poor outcomes in this population as well. The presence and extent of an association between cognitive impairment and poor medication self-management skills in this population has not been clearly defined. OBJECTIVE: We assessed the cognition of consecutive older adults hospitalized for heart failure, in relation to their medication self-management skills...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28540022/rose-bengal-green-light-for-collagen-cross-linking
#16
Mehran Zarei-Ghanavati
No abstract text is available yet for this article.
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28539658/functional-compressive-mechanics-and-tissue-biocompatibility-of-an-injectable-sf-pu-hydrogel-for-nucleus-pulposus-replacement
#17
Jingen Hu, Yang Lu, Ling Cai, Kwabena Gyabaah Owusu-Ansah, Gewen Xu, Feilong Han, Junjie Bao, Xiangjin Lin, Yiping Huang
In spinal degenerative disease, an injectable liquid hydrogel can fill in defect entirely, lessen the danger of implant relocation and following loss of disc height, minimizing the operative trauma. Here, we propose an injectable in-situ chemically cross-linked hydrogel by a two-component reaction of liquid silk fibroin with liquid polyurethane at physiological temperature conditions. Confined compression tests and fatigue tests were reported to assess physical properties of the hydrogel. Impact of different diameter on the biomechanical behaviours was tested to evaluate the clinical potentiality of the hydrogel for replacing nucleus pulposus...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539485/correction-to-quantification-of-the-efficacy-of-collagen-cross-linking-agents-to-induce-stiffening-of-rat-sclera
#18
Ian C Campbell, Bailey G Hannon, A Thomas Read, Joseph M Sherwood, Stephen A Schwaner, C Ross Ethier
No abstract text is available yet for this article.
May 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28539448/virological-control-by-the-cd4-binding-site-antibody-n6-in-shiv-infected-rhesus-monkeys
#19
Boris Julg, Amarendra Pegu, Peter Abbink, Jinyan Liu, Amanda Brinkman, Katherine Molloy, Shanell Mojta, Abishek Chandrashekar, Katherine Callow, Keyun Wang, Xuejun Chen, Stephen D Schmidt, Jinghe Huang, Richard A Koup, Michael S Seaman, Brandon F Keele, John R Mascola, Mark Connors, Dan H Barouch
Passive immunotherapies against HIV-1 will most likely require broadly neutralizing antibodies (bnAb) with maximum breadth and potency to assure therapeutic efficacy. Recently, the novel CD4 binding site antibody N6 demonstrated extraordinary neutralization breadth and potency against large panels of cross clade pseudoviruses. We evaluated the in-vivo antiviral activity of N6-LS, alone or in combination with the established V3-glycan antibody PGT121, in chronically SHIV-SF162P3 infected macaques. A single dose of N6-LS suppressed plasma viral loads in 4 out of 5 animals at day 7 (mean 1...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28539272/selenium-nanoparticles-as-versatile-carriers-for-oral-delivery-of-insulin-insight-into-the-synergic-antidiabetic-effect-and-mechanism
#20
Wenji Deng, Qian Xie, Huan Wang, Zhiguo Ma, Baojian Wu, Xingwang Zhang
Oral insulin delivery has been plagued by limited bioavailability. This work reports selenium nanoparticles (SeNPs) for oral insulin delivery to overcome the absorption barrier. Insulin-loaded SeNPs (INS-SeNPs) were fabricated by ionic cross-linking/in situ reduction and characterized by particle size and drug entrapment. The resultant INS-SeNPs were 120nm around in particle size with high drug loading. INS-SeNPs exhibited controllable insulin release and outstanding stability in the digestive fluids. INS-SeNPs caused a significant hypoglycemic effect in both normal and diabetic rats...
May 21, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
keyword
keyword
47841
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"