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Ocular adnexal lymphoma

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https://www.readbyqxmd.com/read/27894880/lymphoma-of-the-eyelid
#1
REVIEW
Frederik Holm Svendsen, Steffen Heegaard
Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases--14%) and diffuse large B-cell lymphoma (18 cases--9%). T-cell lymphomas are most frequently mycosis fungoides (25 cases--13%), extranodal NK/T-cell, nasal type lymphoma (12 cases--6%) and primary cutaneous anaplastic large cell lymphoma (12 cases--6%)...
November 25, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27830722/comprehensive-polymerase-chain-reaction-assay-for-detection-of-pathogenic-dna-in-lymphoproliferative-disorders-of-the-ocular-adnexa
#2
Yoshihiko Usui, Narsing A Rao, Hiroshi Takase, Kinya Tsubota, Kazuhiko Umazume, Daniel Diaz-Aguilar, Takeshi Kezuka, Manabu Mochizuki, Hiroshi Goto, Sunao Sugita
Infectious agents have been identified as a major cause of specific types of human cancers worldwide. Several microorganisms have been identified as potential aggravators of ocular adnexal neoplasms; however, given the rarity of these neoplasms, large epidemiological studies are difficult to coordinate. This study aimed to conduct an exhaustive search for pathogenic DNA in lymphoproliferative disorders (LPD) of the ocular adnexa in a total of 70 patients who were diagnosed with LPD of the ocular adnexa between 2008 and 2013...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793489/eyelid-lymphoma-in-a-patient-with-a-gold-weight-implant
#3
L A Di Nisio, J O Croxatto, M C Mansur, J P Aldecoa, D Weil
CASE REPORT: A male patient with an exposure keratopathy caused by lagophthalmos. A gold weight was implanted in the right upper eyelid. Eight months later, he presented with erythema and swelling of right upper eyelid. An incisional biopsy was performed, reporting extranodal marginal zone B cell lymphoma. DISCUSSION: when a tumour at the site of a gold weight implant is refractory to treatment, it is essential to perform an incisional biopsy to establish the histopathological diagnosis...
October 25, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27789481/long-term-course-of-patients-with-primary-ocular-adnexal-malt-lymphoma-a-large-single-institution-cohort-study
#4
Amrita Desai, Madhura G Joag, Lazaros Lekakis, Jennifer R Chapman, Francisco Vega, Robert Tibshirani, David Tse, Arnold Markoe, Izidore S Lossos
While Primary Ocular Adnexal MALT Lymphoma (POAML) is the most common orbital tumor, there are large gaps in knowledge of its natural history. We conducted a retrospective analysis of the largest reported cohort, consisting of 182 patients with POAML, diagnosed or treated at our institution to analyze long-term outcome, response to treatment, incidence and localization of relapse and transformation. The majority of patients (80%) presented with stage I disease. Overall, 84% of treated patients achieved a complete response after first-line therapy...
October 27, 2016: Blood
https://www.readbyqxmd.com/read/27686866/ocular-adnexal-marginal-zone-lymphoma-arising-in-a-patient-with-igg4-related-ophthalmic-disease
#5
Kenji Nishida, Yuka Sogabe, Ayako Makihara, Akemi Senoo, Hisanori Morimoto, Mai Takeuchi, Yuka Gion, Tadashi Yoshino, Yasuharu Sato
A 41-year-old man was diagnosed with immunoglobulin G4-related disease (IgG4-RD) in both eyelids 4 years ago and exhibited good response to steroid therapy. However, rapid swelling of the right eyelid lesion was recently observed. As IgG4-RD progression was suspected, biopsy was performed. Although the histology was consistent with IgG4-RD, the infiltrating large atypical lymphoid cells showed immunoglobulin light-chain restriction and IgH gene rearrangement. Consequently, he was diagnosed with extranodal marginal zone lymphoma with abundant IgG4-positive cells...
August 11, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27644607/clinicopathologic-assessment-of-ocular-adnexal-lymphoproliferative-lesions-at-a-tertiary-eye-hospital-in-iran
#6
Fahimeh Asadi-Amoli, Zohreh Nozarian, Hirbod Nasiri Bonaki, Vahid Mehrtash, Samaneh Entezari
BACKGROUND: The most common type of ocular lymphoma is non-Hodgkin lymphoma (NHL), categorized into two groups: indolent (slow growing) and aggressive (rapid growing). Differentiating benign reactive lymphoid hyperplasia (RLH) from malignant ocular adnexal lymphoma (OAL) is challenging. Histopathology, immunohistochemistry (IHC) and ow cytometry have been used as diagnostic tools in such cases. MATERIALS AND METHODS: In this retrospective case series, from 2002 to 2013 at Farabi Eye Center, 110 patients with ocular lymphoproliferative disease were enrolled...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27636243/rates-of-positive-findings-on-positron-emission-tomography-and-bone-marrow-biopsy-in-patients-with-ocular-adnexal-lymphoma
#7
Bradley A Thuro, Jing Ning, S Andrew Peng, Stanley T Pace, Gagan Dudeja, Omar Ozgur, Franceso Turturro, Felipe Samaniego, Fredrick B Hagemeister, Luis E Fayad, Nathan H Fowler, Chelsea C Pinnix, J Matthew Debnam, Bita Esmaeli
PURPOSE: The aim of this study was to determine rates of positive findings on positron emission tomography (PET) and bone marrow biopsy performed during staging workup for ocular adnexal lymphoma (OAL). METHODS: A retrospective review of OAL patients was conducted. Demographics, primary versus secondary OAL, histologic subtype, and findings on PET and bone marrow biopsy performed as part of the initial staging workup for OAL were recorded. RESULTS: The study included 119 patients with OAL...
September 15, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27599769/intracranial-relapse-as-a-solitary-mass-of-ocular-adnexal-lymphoma-of-the-mucosa-associated-lymphoid-tissue-type
#8
Jung-Ho Kim, Young-Woo Jeon, Byung-Ock Choi, Gyeongsin Park, Yong-Kil Hong, Suk-Woo Yang, Seok-Goo Cho
No abstract text is available yet for this article.
September 7, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27566587/recurrent-mutations-in-nf-%C3%AE%C2%BAb-pathway-components-kmt2d-and-notch1-2-in-ocular-adnexal-malt-type-marginal-zone-lymphomas
#9
Patricia Johansson, Ludger Klein-Hitpass, Florian Grabellus, Georg Arnold, Wolfram Klapper, Roman Pförtner, Ulrich Dührsen, Anja Eckstein, Jan Dürig, Ralf Küppers
The pathogenesis of ocular adnexal marginal zone lymphomas of mucosa-associated lymphatic tissue-type (OAML) is still poorly understood. We analyzed 63 cases of such lymphomas for non-synonymous mutations in 24 candidate genes by amplicon sequencing. We validated frequent mutations in the NF-κB regulators MYD88, TNFAIP3 and TNIP1 in OAML, but also identified recurrent mutations in several additional components of the NF-κB pathway, including BCL10 and NFKBIA. Overall, 60% of cases had mutations in at least one component of NF-κB signaling, pointing to a central role of its genetic deregulation in OAML pathogenesis...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27533512/conjunctival-lymphoma-in-a-patient-on-fingolimod-for-relapsing-remitting-multiple-sclerosis
#10
Karen L Christopher, Victor M Elner, Hakan Demirci
The authors describe a 39-year-old woman treated with fingolimod for relapsing-remitting multiple sclerosis for 2 years who then developed a bilateral conjunctival mucosa-associated lymphoid tissue lymphoma. Fingolimod treatment for multiple sclerosis has been associated with lymphoma in 3 previously reported cases. This is the first case of ocular adnexal lymphoma presumed to be due to fingolimod. Given that ophthalmologists regularly monitor many patients on fingolimod for fingolimod-associated macular edema and ophthalmic manifestations of multiple sclerosis, the authors hope to alert physicians of the possibility of ocular adnexal lymphoma in these patients...
August 16, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27435913/chlamydia-and-ocular-adnexal-lymphomas-an-indian-experience
#11
Mansi Bhardwaj, Anjana Sharma, Seema Sen, Lalit Kumar, Gita Satpathy, Seema Kashyap, Neelam Pushker, Vijay Kumar Singh, Arvind Rai
AN INDIAN EXPERIENCE: Ocular adnexal lymphomas (OALs) are a heterogeneous group of malignancies, majority being extranodal mucosa-associated lymphoid tissue (MALT) type. Different geographical regions have reported association of Chlamydia with OALs (MALT type). In India, role of Chlamydia in OALs remains unexplored. The aim of this study was to detect Chlamydia and to correlate with clinicopathological features of OALs in India. The clinicopathological features of 41 OAL cases were studied prospectively. Chlamydia DNA was detected by genus specific PCR amplifying major outer membrane protein (MOMP) gene followed by DNA sequencing...
August 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27300646/ocular-adnexal-lymphoma-presenting-as-refractory-unilateral-open-angle-glaucoma
#12
Nathaniel C Sears, Annapurna Singh, Arun D Singh
We report a single case of masquerade glaucoma caused by increased episcleral venous pressure from adnexal lymphoma. The patient presented as a referral for unilateral glaucoma with intraocular pressures (IOPs) consistently >40 mm Hg (right eye). We present data conclusively demonstrating extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the involved eye, and provide an account of the treatment of the tumor with sustained regression and complete resolution of his elevated IOP. We conclude with a discussion of the proposed mechanism...
August 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27256688/bilateral-ocular-panadnexal-mass-as-initial-presentation-of-systemic-blastoid-variant-of-mantle-cell-lymphoma
#13
REVIEW
Dejan M Rašić, Miroslav Knežević, Tatjana Terzić, Gordana Vlajković
A 66-year-old man developed a slowly enlarging, bilateral, painless, periorbital, and orbital swelling with ptosis, nonaxial proptosis, chemosis, exposure keratopathy, and decreased vision in both eyes. He had fever, night sweats, and weight loss (B-symptoms), along with lymphadenopathy and elevated serum lactate dehydrogenase, with no prior history of lymphoma. A transpalpebral incisional biopsy revealed a rare case of mantle-cell lymphoma of blastoid variant, stage IVB. The main immunophenotype characteristics were cyclin D1+, CD5+, CD10-, CD23-, Bcl-6-/+, and a high (up to 80%) Ki-67 proliferation index...
May 30, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27239457/eyelid-metastatic-thyroid-papillary-carcinoma
#14
Hardeep Singh Mudhar, Murtuza Nuruddin, Soma Rani Roy
PURPOSE: The aim of this study was to report the clinical and histopathological features of an eyelid metastasis in a 70-year-old male with no prior medical history. METHODS: A 70-year-male presented with a painless, hard, red nodular growth in his left lower medial eyelid of 6 months duration, involving the canaliculus and punctum. He did not complain of any other ocular or systemic abnormality. The clinical differential diagnosis included lymphoma or a primary adnexal tumour...
April 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27127077/lymphoid-hyperplasia-of-the-orbit-and-ocular-adnexa-a-clinico-pathological-review
#15
Nicholas H Andrew, Sarah E Coupland, Adnan Pirbhai, Dinesh Selva
Lymphoid hyperplasia (LH) is a benign lymphoproliferative disorder that, in a minority of cases, may be associated with concurrent or metachronous non-Hodgkin lymphoma (NHL) . LH cases are further subdivided into 'reactive' and 'atypical' categories based upon the presence or absence of unequivocal malignant features. With improving molecular diagnostic technologies, 'reactive' LH is by far the most common category of LH, with atypical LH accounting for only a small minority of specimens. Similarly, lesions previously diagnosed as LH are now being revised as low-grade B-cell NHL or diagnosed as newly described benign conditions such as IgG4-related disease...
April 25, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27125186/favourable-response-to-rituximab-by-an-ocular-adnexal-primary-lymphoma
#16
M L Luque Valentin-Fernandez, F Alvarez Rodríguez, I Rodríguez Jiménez
CASE REPORT: A 70-year-old woman who presented with an extranodal marginal zone B-cell lymphoma in lacrimal gland and conjunctiva. Initial treatment with rituximab yielded an immediate good response. Five months later she showed lymphoid proliferation in her contralateral conjunctiva. Although no additional treatment was performed, the patient has been free of systemic symptoms and recurrences. DISCUSSION: Rituximab is a quite good therapeutic agent in low grade adnexal lymphomas...
April 25, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27102345/comprehensive-genomic-profiling-of-orbital-and-ocular-adnexal-lymphomas-identifies-frequent-alterations-in-myd88-and-chromatin-modifiers-new-routes-to-targeted-therapies
#17
Andi K Cani, Moaaz Soliman, Daniel H Hovelson, Chia-Jen Liu, Andrew S McDaniel, Michaela J Haller, Jarred V Bratley, Samantha E Rahrig, Qiang Li, César A Briceño, Scott A Tomlins, Rajesh C Rao
Non-Hodgkin lymphoma of the orbit and ocular adnexa is the most common primary orbital malignancy. Treatments for low- (extra-nodal marginal zone and follicular lymphomas) and high-grade (diffuse large B-cell lymphoma) are associated with local and vision-threatening toxicities. High-grade lymphomas relapse frequently and exhibit poor survival rates. Despite advances in genomic profiling and precision medicine, orbital and ocular adnexal lymphomas remain poorly characterized molecularly. We performed targeted next-generation sequencing (NGS) profiling of 38 formalin-fixed, paraffin-embedded orbital and ocular adnexal lymphomas obtained from a single-center using a panel targeting near-term, clinically relevant genes...
July 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27095383/a-primary-bone-diffuse-large-b-cell-lymphoma-with-ocular-adnexal-involvement
#18
Rafet Eren, Ceyda Aslan, Cihan Gündoğan, Osman Yokuş, Mehmet Hilmi Doğu, Elif Suyanı
No abstract text is available yet for this article.
September 5, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27012277/prediction-of-the-response-of-ocular-adnexal-lymphoma-to-chemotherapy-using-combined-pretreatment-dynamic-contrast-enhanced-and-diffusion-weighted-mri
#19
Pengde Guo, Zhaohui Liu, Fei Yan, Jingwen Wang, Liqiang Wei, Han Lv, Zhenchang Wang, Junfang Xian
BACKGROUND: There are no established biomarkers predictive of the efficacy of treatment for ocular adnexal lymphoma (OAL). PURPOSE: To evaluate the effectiveness of pretreatment dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) in predicting the response of OAL to chemotherapy. MATERIAL AND METHODS: Twenty-one patients, who were pathologically diagnosed with OAL, were retrospectively analyzed...
March 24, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27011948/ocular-adnexal-lymphoma-presenting-with-visual-loss
#20
Shuchi Gulati, Zélia M Corrêa, Nagla Karim, Stephen Medlin
CONTEXT: Elderly patients with visual loss often have age-related macular degeneration, diabetic retinopathy, glaucoma, and cataract as common causes of visual loss. Other less common etiologies should be considered, especially in those presenting with systemic associations. CASE REPORT: The patient discussed in our review is an 80-year-old female, with a history of diabetic retinopathy and macular degeneration who presented with a sudden deterioration of vision...
January 2016: North American Journal of Medical Sciences
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