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Ocular adnexal lymphoma

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https://www.readbyqxmd.com/read/29125145/the-2017-doyne-lecture-the-orbit-as-a-window-to-systemic-disease
#1
REVIEW
A A McNab
A very large number of disorders affect the orbit, and many of these occur in the setting of systemic disease. This lecture covers selected aspects of orbital diseases with systemic associations in which the author has a particular clinical or research interest. Spontaneous orbital haemorrhage often occurs in the presence of bleeding diatheses. Thrombosis of orbital veins and ischaemic necrosis of orbital and ocular adnexal tissues occur with thrombophilic disorders, vasculitis, and certain bacterial and fungal infections...
November 10, 2017: Eye
https://www.readbyqxmd.com/read/29121219/clinicopathological-features-of-ocular-adnexal-mantle-cell-lymphoma-in-an-international-multicenter-cohort
#2
Marina K H Knudsen, Peter K Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Jwu Jin Khong, Penny A McKelvie, Kaustubh Mulay, Elisabeth Ralfkiaer, Lene D Sjö, Geeta K Vemuganti, Bradley A Thuro, Jeremy Curtin, Steffen Heegaard
Importance: To our knowledge, the clinical features of ocular adnexal mantle-cell lymphoma (OA-MCL) have not previously been evaluated in a large multicenter cohort. Objective: To characterize the clinical features of OA-MCL. Design, Setting, and Participants: This retrospective multicenter study included patient data collected from January 1, 1980, through December 31, 2015, at 6 eye cancer centers in 4 countries. Medical records of 55 patients with OA-MCL were reviewed; the median length of follow-up was 33 months...
November 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29113392/chemotherapy-alone-is-an-alternative-treatment-in-treating-localized-primary-ocular-adnexal-lymphomas
#3
Wei-Li Ma, Ming Yao, Shu-Lang Liao, Jih-Luh Tang, Yao-Ching Wang, Sung-Hsin Kuo, Ann-Lii Cheng
This study investigated the treatment efficacy and long-term adverse effects of various treatment modalities for primary ocular adnexal lymphomas (POALs). We retrospectively reviewed 107 patients who received first-line chemotherapy, radiotherapy, and other treatment modalities from 1990 to 2015. Nighty-three (87%) patients were diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma, with the orbit being the most common site (49 patients, 46%). Among 91 patients with stage I-IIE1 disease, 26 underwent chemotherapy, 34 underwent radiotherapy, and 31 received other treatment modalities...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29037024/treatment-outcome-and-risk-analysis-for-cataract-after-radiotherapy-of-localized-ocular-adnexal-mucosa-associated-lymphoid-tissue-malt-lymphoma
#4
Hee Hyun Park, Sea-Won Lee, Soo Yoon Sung, Byung Ock Choi
PURPOSE: We retrospectively reviewed the results of radiotherapy for localized ocular adnexal MALT lymphoma (OAML) to investigate the risk factors of cataract. METHODS: Sixty-seven patients with stage IE OAML treated with radiotherapy at Seoul St. Mary's Hospital from 2001 to 2016 were included. Median treatment dose was 30 Gy. Lens protection was done in 52 (76%) patients. Radiation therapy (RT) extent was as follows: superficial (82.1%), tumor mass (4.5%), and entire orbital socket (13...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28993856/-malignant-lymphomas-of-the-eye
#5
REVIEW
F Fend, D Süsskind, C Deuter, S E Coupland
The eye and the ocular adnexae are rare sites for malignant non-Hodgkin lymphoma (NHL). Based on their anatomical location, intraocular lymphomas must be discerned from NHL of adnexal structures including conjunctiva, lacrimal gland, and orbit. Whereas the latter group mostly consists of indolent extranodal marginal zone B‑cell lymphomas of mucosa-associated lymphoid tissue (MALT) type or secondary manifestations of systemic NHL, most primary intraocular lymphomas are classified as diffuse large B‑cell lymphomas (DLBCL) and are considered a variant of primary DLBCL of the central nervous system...
November 2017: Der Pathologe
https://www.readbyqxmd.com/read/28978139/frontline-treatment-with-chemoimmunotherapy-for-limited-stage-ocular-adnexal-malt-lymphoma-with-adverse-factors-a-phase-ii-study
#6
Sung-Yong Kim, Suk-Woo Yang, Won-Sik Lee, Jae Wook Yang, Sung Yong Oh, Hee Bae Ahn, Deok-Hwan Yang, Seong Kyu Park, Jee Ho Chang, Hyo Jung Kim, Min Joung Lee, Seok-Goo Cho
BACKGROUND: Radiotherapy is a commonly used treatment for limited-stage ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) but showed a substantial relapse risk if the disease involves beyond-conjunctiva or bilateral conjunctivae. Systemic chemoimmunotherapy may be an alternative frontline therapy for the limited disease with those adverse prognostic factors. PATIENTS AND METHODS: We designed a multicenter, phase II study of the chemoimmunotherapy, rituximab, cyclophosphamide, vincristine, and prednisolone (R-CVP) for the treatment of patients with limited-stage OAML with bilateral or beyond-conjunctival involvement...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28939925/ocular-adnexal-marginal-zone-lymphoma-of-mucosa-associated-lymphoid-tissue
#7
REVIEW
Dimitrios Kalogeropoulos, Alexandra Papoudou-Bai, Panagiotis Kanavaros, Chris Kalogeropoulos
Ocular adnexal lymphomas are a group of heterogeneous neoplasms representing approximately 1-2% of non-Hodgkin lymphomas and 8% of extranodal lymphomas. The incidence of primary ocular adnexal lymphoid tumors has raised over the last decades, and this could be probably attributed to the more sophisticated diagnostic techniques. Due to the wide spectrum of clinical manifestations, ocular tissue biopsy is important in order to set a precise diagnosis based on histological, immunophenotypical and, in some cases, molecular findings...
September 22, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/28880986/association-of-disease-location-and-treatment-with-survival-in-diffuse-large-b-cell-lymphoma-of-the-eye-and-ocular-adnexal-region
#8
Aseef H Ahmed, C Stephen Foster, Carol L Shields
Importance: Primary diffuse large B-cell lymphoma (DLBCL) of the ocular region is rare, and the utility of surgery and radiation therapy remains unresolved. Objective: To explore the clinical characteristics and determine factors associated with overall survival in primary vitreoretinal lymphoma (PVRL) and ocular adnexal (OA)-uveal DLBCL. Design, Setting, and Participants: This retrospective analysis included 396 patients with ophthalmic DLBCL from January 1, 1973, through December 31, 2014, using the Surveillance, Epidemiology, and End Results database...
October 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28837797/ocular-adnexal-lymphoma-dissimilar-to-systemic-lymphoma
#9
REVIEW
Tal J Rubinstein, Hassan A Aziz, Claudine Bellerive, Bryan S Sires, Andrew W Hing, Gabriel Habermehl, Eric Hsi, Arun D Singh
Ocular adnexal lymphoma and intraocular lymphoma, whether occurring simultaneously or sequentially, are often similar to associated systemic lymphoma. We describe 4 cases of ocular adnexal lymphoma or intraocular lymphoma with a dissimilar systemic lymphoma. Two of the cases represent Richter transformation of chronic lymphocytic leukemia/small-cell lymphoma into diffuse large B-cell lymphoma. In the third patient, conjunctival extranodal marginal zone lymphoma developed following treatment for Hodgkin lymphoma...
August 31, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28829109/adult-orbital-and-adnexal-xanthogranulomatous-disease
#10
Michael J Davies, Kevin Whitehead, Gary Quagliotto, Dominic Wood, Rajan S Patheja, Timothy J Sullivan
PURPOSE: Adult xanthogranulomatous disease of the orbit and ocular adnexa is a rare disease that can cause serious morbidity and mortality. Ophthalmologists are commonly the first clinicians to come in contact with affected patients and an understanding of the clinical features is essential. DESIGN: We present a retrospective case series of patients seen in the oculoplastic unit of a large tertiary referral hospital over a 20-year period. METHODS: The clinical files of 7 patients with adult xanthogranulomatous disease of the orbit and ocular adnexa were reviewed...
September 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28814410/characteristics-of-primary-extranodal-marginal-zone-b-cell-lymphoma-in-korea-conjunctiva-versus-other-ocular-adnexa
#11
Seung Wan Nam, Kyung In Woo, Yoon-Duck Kim
AIMS: To compare the clinical characteristics and prognosis of primary conjunctival versus other ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL). METHODS: Retrospective review of clinical records for all consecutive patients with primary ocular adnexal EMZL treated from March 1995 to December 2015. RESULTS: 198 patients were evaluated including 81 with primary conjunctival and 117 with other ocular adnexal EMZL. Conjunctival EMZL was found at a younger age (40...
August 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28749851/immunoglobulin-g4-igg4-positive-ocular-adnexal-mucosa-associated-lymphoid-tissue-lymphoma-and-idiopathic-orbital-inflammation
#12
Eun Jung Sohn, Hee Bae Ahn, Mee Sook Roh, Woo Jun Jung, Won Yeol Ryu, Yoon Hyung Kwon
PURPOSE: To report clinical and pathological characteristics of idiopathic orbital inflammation and ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma with immunoglobulin G4 (IgG4)-positive plasma cells. METHODS: A retrospective histopathological review and clinical case series. A total of 51 biopsy samples from January 2005 to December 2015 were used in this study, including 21 cases of biopsy-confirmed idiopathic orbital inflammation and 30 cases of biopsy-confirmed ocular adnexal MALT lymphoma...
July 26, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28712656/treatments-for-ocular-adnexal-lymphoma-a-report-by-the-american-academy-of-ophthalmology
#13
Michael T Yen, Jurij R Bilyk, Edward J Wladis, Elizabeth A Bradley, Louise A Mawn
PURPOSE: To review the literature to determine the efficacy of available treatments for ocular adnexal lymphoma (OAL) and to evaluate the outcomes and complications of treatments in patients older than 13 years. METHODS: A literature search was conducted last in March 2017 in the PubMed and Cochrane Library databases for English-language original research investigations that evaluated treatment outcomes for OAL. The searches identified 307 unique citations, and 27 studies were selected according to the criteria outlined for this assessment...
July 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28682481/significant-association-between-tnfaip3-inactivation-and-biased-immunoglobulin-heavy-chain-variable-region-4-34-usage-in-mucosa-associated-lymphoid-tissue-lymphoma
#14
Sarah Moody, Leire Escudero-Ibarz, Ming Wang, Alexandra Clipson, Eguzkine Ochoa Ruiz, Deborah Dunn-Walters, Xuemin Xue, Naiyan Zeng, Alistair Robson, Shih-Sung Chuang, Sergio Cogliatti, Hongxiang Liu, John Goodlad, Margaret Ashton-Key, Markus Raderer, Yingwen Bi, Ming-Qing Du
Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development critically depends on their cooperation. However, which of these different events concur and how they cooperate in MALT lymphomagenesis is totally unknown. To explore this, we investigated somatic mutations of 17 genes and immunoglobulin heavy chain variable region (IGHV) usage in 179 MALT lymphomas from various sites...
September 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28644136/chemotherapy-alone-is-an-alternative-treatment-in-treating-localized-primary-ocular-adnexal-lymphomas
#15
Wei-Li Ma, Ming Yao, Shu-Lang Liao, Jih-Luh Tang, Yao-Ching Wang, Sung-Hsin Kuo, Ann-Lii Cheng
This study investigated the treatment efficacy and long-term adverse effects of various treatment modalities for primary ocular adnexal lymphomas (POALs). We retrospectively reviewed 107 patients who received first-line chemotherapy, radiotherapy, and other treatment modalities from 1990 to 2015. Nighty-three (87%) patients were diagnosed with mucosa-associated lymphoid tissue (MALT) lymphoma, with the orbit being the most common site (49 patients, 46%). Among 91 patients with stage I-IIE1 disease, 26 underwent chemotherapy, 34 underwent radiotherapy, and 31 received other treatment modalities...
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28546924/the-expressions-of-metadherin-and-lef-1-in-mucosa-associated-lymphoid-tissue-lymphoma-of-ocular-adnexal
#16
Dan Qi, Hong Lin, Yan Gao, Jing Lin, Li-Ting Hu, Gui-Qiu Zhao
AIM: To investigate the expressions of metadherin (astrocyte elevated gene-1, AEG-1) and lymphoid enhancer-binding factor-1 (LEF-1) in ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma. METHODS: The expressions of AEG-1 and LEF-1 were detected on specimens harvested from patients suffering from MALT lymphoma and lymphadenosis of ocular adnexal in Ophthalmology Department, Affiliated Hospital of Qingdao University from 2000 to 2015 by immunohistochemical and polymerase chain reaction (PCR) analysis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28514197/change-of-serum-igg4-in-patients-with-ocular-adnexal-marginal-zone-b-cell-lymphoma-associated-with-igg4-related-ophthalmic-disease-after-treatment
#17
Yuan-Hung Wu, Lei-Chi Wang, Sang-Hue Yen, Wei-Kuang Yu, Shu-Ching Kao, Hui-Chuan Kau, Chieh-Chih Tsai, Catherine Jui-Ling Liu
PURPOSE: To investigate the change of serum IgG4 concentrations correlated with clinical evolution in patients with ocular adnexal marginal zone B cell lymphoma associated with IgG4-related ophthalmic disease (IgG4-ROD). METHODS: Three consecutive patients with histopathologically confirmed ocular adnexal marginal zone B cell lymphoma associated with IgG4-ROD were evaluated. Two patients received radiotherapy and 1 patient received steroid therapy. Treatment outcome was evaluated by clinical symptoms, radiologic examination, and change of serum IgG4 level in these patients...
September 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28510589/establishment-of-a-combination-scoring-method-for-diagnosis-of-ocular-adnexal-lymphoproliferative-disease
#18
Xiao-Li Qu, Yan Hei, Li Kang, Xin-Ji Yang, Yi Wang, Xiao-Zhong Lu, Li-Hua Xiao, Guang Yang
Lymphoproliferative diseases (LPDs) of the ocular adnexa encompass the majority of orbital diseases and include reactive follicular hyperplasia (RFH), atypical lymphoid hyperplasia (ALH), and mucosa-associated lymphoid tissue lymphoma (MALToma). Lymphoid follicles (LFs) are usually observed during the histological examination of LPDs. Currently, because there is a lack of specific clinical signs and diagnostic immunohistochemical biomarkers, it is difficult for pathologists to distinguish MALToma from ocular RFH and ALH, which makes the clinical management of these conditions difficult...
2017: PloS One
https://www.readbyqxmd.com/read/28399341/lymphoproliferative-tumors-of-the-ocular-adnexa
#19
REVIEW
Robert M Verdijk
The ocular adnexa include the eyelids, conjunctiva, lacrimal apparatus, and orbital soft tissue. One percent of all lymphomas and approximately 8% of all extranodal lymphomas arise in the ocular adnexa and their incidence is increasing. Reactive lymphoid hyperplasia comprises 16% of all lymphoproliferative tumors of the ocular adnexa. The relative frequencies of ocular adnexal lymphoma presentation are in the orbit, 37%; conjunctiva, 29%; lacrimal apparatus, 20%; and eyelid, 14%. The most frequent primary lymphoma types of the ocular adnexa are extranodal marginal zone lymphoma, 62%; follicular lymphoma, 17%; and diffuse large B-cell lymphoma, 10%...
March 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28370694/ultra-low-dose-radiotherapy-for-definitive-management-of-ocular-adnexal-b-cell-lymphoma
#20
Chelsea C Pinnix, Bouthaina S Dabaja, Sarah A Milgrom, Grace L Smith, Zeinab Abou, Loretta Nastoupil, Jorge Romaguera, Francesco Turturro, Nathan Fowler, Luis Fayad, Jason Westin, Sattva Neelapu, Michelle A Fanale, Maria A Rodriguez, Frederick Hagemeister, Hun Ju Lee, Yasuhiro Oki, Michael Wang, Felipe Samaniego, Linda Chi, Bita Esmaeli
BACKGROUND: The purpose of this study was to report the response to and toxicity of ultra-low-dose radiotherapy (RT) for B-cell ocular adnexal lymphoma (OAL). METHODS: We conducted a retrospective review of patients with indolent B-cell and mantle cell OAL treated with 4 Gy to the orbit(s) in two 2-Gy fractions. Disease response was assessed clinically and/or radiographically at 2 to 4-month intervals after RT. Data collected included rates of overall response, complete response (CR), partial response (PR), and treatment-related toxic effects...
June 2017: Head & Neck
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