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https://www.readbyqxmd.com/read/29046057/bile-duct-ligature-in-young-rats-a-revisited-animal-model-for-biliary-atresia
#1
Matias Garrido, Camila Escobar, Constanza Zamora, Carolina Rejas, Juan Varas, Mario Párraga, Sebastian San Martin, Sandra Montedónico
Biliary atresia leads to cirrhosis in the vast majority of patients and constitutes the first cause of paediatric liver transplantation. Animal models allow us to understand the molecular basis and natural history of diseases. The aim of this study is to describe a surgically created animal model of biliary atresia with emphasis in long-term liver function. Forty-two 3-week-old Sprague-Dawley rats were randomly divided into two groups: bile duct ligature (BDL) and control. The animals were sacrificed on the 2nd, 4th, and 6th postoperative weeks...
September 13, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29045972/-acetylsalicylic-acid-treatment-enhanced-immunomodulatory-function-of-mesenchymal-stem-cells-derived-from-gingiva
#2
R L Yang, T T Yu, Y H Zhou
OBJECTIVE: To analyze the role of acetylsalicylic acid (ASA) in immunomodulation of mesenchymal stem cells derived from gingiva (GMSCs), and to explore the role of ASA in enhancing the immumomodulation of GMSCs and the capacity of GMSCs to treat immune disorders and the underlying mechanism. METHODS: Flow cytometry analysis were used to analyze the role of ASA in the expression of stem cells surface markers CD146, CD105, CD90, CD34 and CD45 in GMSCs,and the GMSCs proliferation was analyzed by 5-bromo-2-deoxyuridine (BrdU) staining and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045955/-comparison-between-continuous-noninvasive-hemoglobin-monitoring-and-venous-blood-hemoglobin-monitoring-in-children-with-kidney-disease
#3
X Y Liu, X Q Yang, H J Xiao, J Ding
OBJECTIVE: To assess the correlation and consistency between continuous noninvasive hemoglobin detection and venous blood hemoglobin detection in children with kidney disease, and try to analyze the affecting factors. Try to provide a reference for the monitoring of hemoglobin in children with kidney disease by continuous noninvasive hemoglobin detection technique. METHODS: Eighty-five inpatient children with kidney disease, 50 boys (58.8%) and 35 girls (41.2%), aged from 3 years old to 18 years old (9...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045947/prediction-of-the-future-need-for-institutional-care-in-finnish-older-people-a-comparison-of-two-birth-cohorts
#4
Marika Salminen, Sini Eloranta, Jenni Vire, Paula Viikari, Laura Viikari, Tero Vahlberg, Aapo Lehtonen, Seija Arve, Maarit Wuorela, Matti Viitanen
BACKGROUND: More recent birth cohorts of older people have better physical and cognitive status than earlier cohorts. As such, this could be expected to diminish the need for institutional care. The prediction of the future need for institutional care provides essential information for the planning and delivery of future care and social services as well as the resources needed. OBJECTIVE: To predict the future need for institutional care among older Finnish people born in 1940...
October 19, 2017: Gerontology
https://www.readbyqxmd.com/read/29045945/retreatment-of-exudative-age-related-macular-degeneration-after-loading-3-monthly-intravitreal-ranibizumab
#5
Atsushi Sugiyama, Yoichi Sakurada, Shigeru Honda, Akiko Miki, Wataru Matsumiya, Seigo Yoneyama, Wataru Kikushima, Hiroyuki Iijima
PURPOSE: The aim of this study was to investigate the clinical implications of required retreatment after 3-monthly intravitreal ranibizumab (IVR) injections followed by as-needed reinjections up to 5 years in eyes with exudative age-related macular degeneration (AMD). METHODS: A retrospective cohort study was conducted for 165 treatment-naïve eyes from 165 patients with exudative AMD. Visual changes were investigated in terms of the required retreatments. RESULTS: Retreatment-free proportions were 37...
October 19, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29045943/reference-ranges-for-fetal-atrioventricular-and-ventriculoatrial-time-intervals-and-their-ratios-during-normal-pregnancy
#6
Beatrice Mosimann, Georgios Arampatzis, Sofia Amylidi-Mohr, Anice Bessire, Marialuigia Spinelli, Petros Koumoutsakos, Daniel Surbek, Luigi Raio
BACKGROUND: The diagnostic assessment of fetal arrhythmias relies on the measurements of atrioventricular (AV) and ventriculoatrial (VA) time intervals. Pulsed Doppler over in- and outflow of the left ventricle and tissue Doppler imaging are well-described methods, while Doppler measurements between the left brachiocephalic vein and the aortic arch are less investigated. The aim of this study was to compare these methods of measurement, to find influencing factors on AV and VA times and their ratio, and to create reference ranges...
October 19, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29045939/very-low-dose-decitabine-is-effective-in-treating-intermediate-or-high-risk-myelodysplastic-syndrome
#7
Hongmin Li, Liru Wang, Yue Wu, Li Su, Hong Zhao, Yongqing Zhang, Zhao Wang, Dayong Huang, Zhongxia Huang, Xiaoxiong Wu, Xiaohong Li, Fang Ye, Fan Yu, Hui Liu, Jing-Wen Wang, Jia Cong, Wanjun Sun, Hui-Ren Chen, Jingbo Wang, Bing Han
Nowadays, the regular recommended dose of decitabine for the treatment of myelodysplastic syndrome (MDS) is 20 mg/m2/day for 5 consecutive days with a relatively high incidence of treatment-related morbidities and costs. In this study, a retrospective and multicenter analysis was performed to explore the very-low-dose decitabine schedule for the treatment of patients with IPSS intermediate- or high-risk MDS. A total of 31 newly diagnosed MDS cases from 14 hospitals in Beijing received decitabine monotherapy (decitabine 6 mg/m2/day intravenously for 7 consecutive days, repeated every 4 weeks)...
October 19, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/29045885/fabrication-and-use-of-plga-based-formulations-designed-for-modified-release-of-5-fluorouracil
#8
REVIEW
Nattawut Leelakanok, Sean Geary, Aliasger Salem
5-fluorouracil (5-FU) is a chemotherapeutic agent that has been used for the treatment of a variety of malignancies since its initial introduction to the clinic in 1957.(1) Due to its short biological half-life, multiple dosings are generally required to maintain effective 5-FU plasma concentrations throughout the therapeutic period. Clinical studies have shown that continuous 5-FU administration is generally superior to bolus injection as exhibited by lower toxicities and increased therapeutic efficacy.(2,3) Optimal therapeutic efficacy, however, is often compromised by the limiting therapeutic index...
October 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29045855/prognostic-factors-in-skull-base-chordoma-a-systematic-literature-review-and-meta-analysis
#9
REVIEW
Ming-Xiang Zou, Guo-Hua Lv, Qian-Shi Zhang, Shao-Fu Wang, Jing Li, Xiao-Bin Wang
OBJECTIVE: Currently, there are still lack of reviews assessing the complete range of prognostic factors in skull base chordoma (SBC). This study aimed to systematically review the published literature on prognostic factors in SBC and to establish pooled hazard ratios (HRs) of such factors. METHODS: MEDLINE and EMBASE search (inception to April 04, 2017). Two reviewers independently selected papers involving SBC prognostic factors, and studied them for methodological quality and valuable factors...
October 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29045851/trends-in-pelvic-inflammatory-disease-emergency-department-visits-united-states-2006-2013
#10
Kristen Kreisel, Elaine W Flagg, Elizabeth Torrone
BACKGROUND: Pelvic inflammatory disease is a female genital tract disorder with severe reproductive sequelae. Due to difficulties in diagnosing pelvic inflammatory disease, it is not a reportable condition in many states. Females seeking care in emergency departments are a sentinel population for pelvic inflammatory disease surveillance. OBJECTIVE: To determine trends in diagnoses of acute pelvic inflammatory disease in a nationally representative sample of emergency departments...
October 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29045838/p75-is-required-for-the-establishment-of-postnatal-sensory-neuron-diversity-by-potentiating-ret-signaling
#11
Zhijiang Chen, Christopher R Donnelly, Bertha Dominguez, Yoshinobu Harada, Weichun Lin, Alan S Halim, Tasha G Bengoechea, Brian A Pierchala, Kuo-Fen Lee
Producing the neuronal diversity required to adequately discriminate all elements of somatosensation is a complex task during organogenesis. The mechanisms guiding this process during dorsal root ganglion (DRG) sensory neuron specification remain poorly understood. Here, we show that the p75 neurotrophin receptor interacts with Ret and its GFRα co-receptor upon stimulation with glial cell line-derived neurotrophic factor (GDNF). Furthermore, we demonstrate that p75 is required for GDNF-mediated Ret activation, survival, and cell surface localization of Ret in DRG neurons...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29045798/effects-of-reclamation-years-on-composition-and-diversity-of-soil-bacterial-communities-in-northwest-china
#12
Zhibo Cheng, Fenghua Zhang, William Jeffrey Gale, Weichao Wang, Wen Sang, Haichang Yang
The objective of this study was to evaluate bacterial community structure and diversity in soil aggregate fractions when salinized farmland was reclaimed after > 27 yr of abandonment and then farmed again for 1, 5, 10, and 15 yr. Illumina MiSeq high-throughput sequencing was performed to characterize the soil bacterial communities in five aggregate size classes in each treatment. The results indicated that reclamation significantly increased macro-aggregation (> 0.25 mm), as well as soil organic C, available N, and available P...
October 18, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29045759/the-effect-of-hydroxychloroquine-on-haemostasis-complement-inflammation-and-angiogenesis-in-patients-with-antiphospholipid-antibodies
#13
Karen Schreiber, Karen Breen, Kiran Parmar, Jacob H Rand, Xiao-Xuan Wu, Beverley J Hunt
Objectives: HCQ has been described as having a beneficial effect in patients with APS but its mechanism of action is unclear. We hypothesized that HCQ may have effects on subnormal angiogenesis, inflammation and haemostatic biomarkers seen in APS. The aim of our study was to assess laboratory markers [annexin A5 (AnxA5) anticoagulant activity, tissue factor (TF) levels, thromboelastography (TEG), CRP, Bb, C3a and VEGF] in HCQ-naïve patients with aPL at baseline and after commencing HCQ...
October 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/29045736/clinical-trial-parameters-that-influence-outcomes-in-lupus-trials-that-use-the-systemic-lupus-erythematosus-responder-index
#14
Kenneth C Kalunian, Murray B Urowitz, David Isenberg, Joan T Merrill, Michelle Petri, Richard A Furie, Mary-Ann Morgan-Cox, Rebecca Taha, Steven Watts, Maria Silk, Matthew D Linnik
Objective: The SLE Responder Index (SRI) is a composite endpoint used in SLE trials. This investigation examined the clinical trial elements that drive response measured by the SRI. Methods: Analyses are based on data from two phase 3 trials (n = 2262) that evaluated the impact of an anti-B-cell activating factor antibody on disease activity using SRI-5 as the primary endpoint (ClinicalTrials.gov NCT01196091 and NCT01205438). Results: The SRI-5 response rate at week 52 for all patients was 32...
October 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/29045722/subjective-age-and-cystatin-c-among-older-adults
#15
Yannick Stephan, Angelina R Sutin, Antonio Terracciano, Shevaun Neupert
Objective: Cystatin C (CysC) is a marker of kidney function that is relevant for the health and cognition of older adults. Little is known about the link between psychological factors and CysC. Therefore, the present study examined whether subjective age is related to CysC level and changes in CysC over time. Method: Participants were 5,066 individuals drawn from the Health and Retirement Study aged from 50 to 107 years (60% women, mean age = 69.36 years, SD = 9...
October 16, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29045699/impact-of-hiv-on-the-burden-and-severity-of-influenza-illness-in-malawian-adults-a-prospective-cohort-and-parallel-case-control-study
#16
Antonia Ho, Stephen J Aston, Hannah Jary, Tamara Mitchell, Maaike Alaerts, Mavis Menyere, Jane Mallewa, Mulinda Nyirenda, Dean Everett, Robert S Heyderman, Neil French
Background: The impact of HIV infection on influenza incidence and severity in adults in sub-Saharan Africa is unclear. Seasonal influenza vaccination is recommended for HIV-infected persons in developed settings, but is rarely implemented in Africa. Methods: We conducted a prospective cohort study to compare the incidence of laboratory-confirmed influenza illness between HIV-infected and HIV-uninfected adults in Blantyre, Malawi. In a parallel case-control study, we explored risk factors for severe influenza presentation of severe (hospitalized lower respiratory tract infection (LRTI)), and mild influenza (influenza-like illness (ILI))...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29045671/association-between-self-rated-health-and-ideal-cardiovascular-health-the-baptist-health-south-florida-employee-study
#17
Oluseye Ogunmoroti, Ovie A Utuama, Joseph A Salami, Javier Valero-Elizondo, Erica S Spatz, Maribeth Rouseff, Don Parris, Sankalp Das, Henry Guzman, Arthur Agatston, Theodore Feldman, Emir Veledar, Wasim Maziak, Khurram Nasir
Background: There is increasing evidence of the role psychosocial factors play as determinants of cardiovascular health (CVH). We examined the association between self-rated health (SRH) and ideal CVH among employees of a large healthcare organization. Methods: Data were collected in 2014 from employees of Baptist Health South Florida during an annual voluntary health risk assessment and wellness fair. SRH was measured using a self-administered questionnaire where responses ranged from poor, fair, good, very good to excellent...
October 17, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29045661/factors-associated-with-malnutrition-among-children-5-years-old-in-burkina-faso-evidence-from-the-demographic-and-health-surveys-iv-2010
#18
Ghislain G Poda, Chien-Yeh Hsu, Jane C-J Chao
Objective: To assess the factors associated with malnutrition among children <5 years in Burkina Faso. Design: This study was based on secondary analysis of cross-sectional population-based data from Burkina-Faso Demographic Health Surveys 2010. Setting: This study was carried out in Burkina Faso, West Africa. Participants: The participants were 6337 children <5 years and their mothers. Main outcome measures: Demographic characteristics, child nutrition and health status, and maternal and household information were collected...
October 17, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29045653/a-quality-improvement-project-to-reduce-hypothermia-in-preterm-infants-on-admission-to-the-neonatal-intensive-care-unit
#19
Wai Yan Yip, Bin Huey Quek, Mary Choi Wan Fong, Thilagamangai, Sally Siew Gim Ong, Bee Leong Lim, Bo Chu Lo, Pratibha Agarwal
Objective: To study effectiveness of quality improvement interventions in reducing hypothermia in preterm infants on admission to neonatal intensive care unit. Design: Quality improvement methodologies including multidisciplinary planning and implementation of evidence-based interventions. Data during and post-implementation were collected. Setting and participants: In total, 84 preterm infants with birth weights ≤ 1500 g delivered during implementation period (October 2008-April 2009) were compared with 168 historical controls and 947 infants in the subsequent 4 years...
October 17, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29045566/aesthetic-surgical-procedures-in-men-major-complications-and-associated-risk-factors
#20
Christodoulos Kaoutzanis, Julian Winocour, Max Yeslev, Varun Gupta, Ishan Asokan, Jason Roostaeian, James C Grotting, K Kye Higdon
Background: The number of men undergoing cosmetic surgery is increasing in North America. Objectives: To determine the incidence and risk factors of major complications in males undergoing cosmetic surgery, compare the complication profiles between men and women, and identify specific procedures that are associated with higher risk of complications in males. Methods: A prospective cohort of patients undergoing cosmetic surgery between 2008 and 2013 was identified from the CosmetAssure database...
October 14, 2017: Aesthetic Surgery Journal
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