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https://www.readbyqxmd.com/read/28109191/serum-high-concentrations-of-homocysteine-and-low-levels-of-folic-acid-and-vitamin-b12-are-significantly-correlated-with-the-categories-of-coronary-artery-diseases
#1
Yan Ma, Duanliang Peng, Chenggui Liu, Chen Huang, Jun Luo
BACKGROUND: Homocysteine (Hcy) has been considered as an independent risk factor for coronary artery disease (CAD). Folic acid and vitamin B12 are two vital regulators in Hcy metabolic process. We evaluated the correlations between serum Hcy, folic acid and vitamin B12 with the categories of CAD. METHODS: Serum Hcy, folic acid and vitamin B12 from 292 CAD patients, including 73 acute myocardial infarction (AMI), 116 unstable angina pectoris (UAP), 103 stable angina pectoris (SAP), and 100 controls with chest pain patients were measured, and the data were analyzed by SPSS software...
January 21, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28109182/are-home-visits-an-effective-method-for-diabetes-management-a-quantitative-systematic-review-and-meta-analysis
#2
Lin Han, Yuxia Ma, Suhong Wei, Jinhui Tian, Xiaochun Yang, Xiping Shen, Jun Zhang, Yuexian Shi
AIMS: Previous reviews have revealed uncertainty regarding the effectiveness of home visit interventions for managing diabetes. Therefore, we performed a quantitative systematic review and meta-analysis to evaluate the effects of home visit interventions among patients with diabetes. METHODS: We searched various electronic databases (PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, Wanfang, and Chinese scientific full-text databases) from their inception until March 2016...
January 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28109179/quantitative-and-integrative-analysis-of-paracrine-hepatocyte-activation-by-non-parenchymal-cells-upon-lipopolysaccharide-induction
#3
Katharina Beuke, Frank A Schildberg, Federico Pinna, Ute Albrecht, Roman Liebe, Michaela Bissinger, Peter Schirmacher, Steven Dooley, Johannes G Bode, Percy A Knolle, Ursula Kummer, Kai Breuhahn, Sven Sahle
Gut-derived bacterial lipopolysaccharides (LPS) stimulate the secretion of tumor necrosis factor (TNF) from liver macrophages (MCs), liver sinusoidal endothelial cells (LSECs), and hepatic stellate cells (HSCs), which control the acute phase response in hepatocytes through activation of the NF-κB pathway. The individual and cooperative impact of non-parenchymal cells on this clinically relevant response has not been analysed in detail due to technical limitations. To gain an integrative view on this complex inter- and intracellular communication, we combined a multi-scale mathematical model with quantitative, time-resolved experimental data of different primary murine liver cell types...
January 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28109147/-co-culture-with-umbilical-cord-mesenchymal-stem-cells-promotes-the-synthesis-and-mechnism-of-milk-protein-in-bovine-mammary-epithelial-cells
#4
Yankun Zhao, Wei Shao, Chenglong Luo, Kaile Wu, Xiong Yu
Objective To explore the possible mechanism of umbilical cord mesenchymal stem cells (UCMSCs) regulating milk protein synthesis in bovine mammary gland epithelial cells (BMECs). Methods UCMSCs and BMECs were co-cultured by double-chamber Transwell(TM), and other BMECs were cultured alone as a control group. Insulin like growth factor 1 receptor (IGF-1R) inhibitor AG1024 was used to treat cells. IGF-1, β casein (CSN2) and κ casein (CSN3) content in the supernatants were determined by ELISA; the relative expression abundance of Janus kinase and signal transducer and activator of transcription factor (JAK/STAT) signaling pathway-related genes were detected by quantitative real-time PCR (qRT-PCR); and after the cells were treated with JAK2 signal blocker AG490, qRT-PCR was performed to test the relative expression abundance of CSN2 and CSN3 mRNAs...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28109144/-interferon-regulatory-factor-5-irf5-regulates-the-differentiation-of-bone-marrow-derived-macrophages-in-mice
#5
Kang Sun, Jianguo Qu, Jixiang Chen, Shengchun Dang, Songbing He, Jin Zhang, Rong Xie, Yun Wang, Jianxin Zhang
Objective To investigate the expression differences of interferon regulatory factor 5 (IRF5) between M1 and M2 macrophages derived from mouse bone marrow and the effects of small interfering RNA targeting IRF5 gene (IRF5 siRNA) on macrophage differentiation. Methods With the treatment of IFN-γ and lipopolysaccharide (LPS), mouse bone marrow-derived macrophages were differentiated into M1 macrophages; while with the treatment of IL-4, mouse bone marrow-derived macrophages were differentiated into M2 macrophages...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28109102/-long-term-outcomes-of-off-pump-coronary-artery-bypass-grafting-in-patients-aged-over-75-years
#6
Yi Guo, Chong-Lei Ren, Chang-Qing Gao, Cang-Song Xiao, Hua-Jun Zhang
OBJECTIVE: To investigate the long-term outcomes of off-pump coronary artery bypass grafting (OPCAB) in patients aged over 75 years and analyze the risk factors affecting the outcomes of the procedure. METHODS: Clinical data were reviewed for 97 consecutive patients aged 75 years or above receiving OPCAB at our center between November, 2000 and November, 2013. The perioperative data including length of ICU stay, duration of mechanical ventilation, incidence of postoperative complications and mortality rate of the patients were analyzed...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28109084/mir-5195-3p-inhibits-proliferation-and-invasion-of-human-bladder-cancer-cells-by-directly-targeting-oncogene-klf5
#7
Zhangjie Jiang, Yida Zhang, Runfu Cao, Li Li, Kezhao Zhong, Qingsheng Chen, Jianjun Xiao
MiRNAs played key roles in carcinogenesis of many cancers including bladder cancer. In current study, the role of miR-5195-3p, a quite recently discovered and poorly studied miRNA, in the proliferation and invasion of human bladder cancer cells was investigated. Our data displayed that, compared with the healthy volunteers (control) and SU-HUC-1 human normal bladder epithelial cells, miR-5195-3p was sharply down-regulated in the bladder cancer patients and 5 human bladder cancer cell lines. Then, the oligo miR-5195-3p mimic or miR-5195-3p antagomir was respectively transfected into both T24 and BIU-87 bladder cancer cell lines...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109070/peste-des-petits-ruminants-risk-factors-and-space-time-clusters-in-mymensingh-bangladesh
#8
M S Rony, A K M A Rahman, M M Alam, N Dhand, M P Ward
Using a hospital-based case-control study design, our aim was to identify risk factors for-and space-time clusters of-Peste des Petits Ruminants (PPR) in Mymensingh, Bangladesh. Three hundred and eighty PPR cases diagnosed between January 2005 and December 2014 at the Bangladesh Agricultural University Veterinary Teaching Hospital (BAUVTH) were selected; three controls per case from BAUVTH were then selected (n = 1,048). From records, data extracted included information on date of report, location, age, breed, sex and body weight of goats...
January 21, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28109042/expression-and-characterization-of-a-codon-optimized-blood-coagulation-factor-viii
#9
S A Shestopal, J-J Hao, E Karnaukhova, Y Liang, M V Ovanesov, M Lin, J H Kurasawa, T K Lee, J H McVey, A G Sarafanov
BACKGROUND: Production of recombinant factor VIII (FVIII) is challenging due to its low expression. It was previously shown that codon-optimization of a B domain-deleted FVIII (BDD-FVIII) cDNA resulted in increased protein expression. However, it is well-recognized that synonymous mutations may affect the protein structure and function. OBJECTIVES: To compare biochemical properties of a BDD-FVIII expressed from codon-optimized (CO) and the wild-type (WT) cDNAs. METHODS: Each variant of the BDD-FVIII was expressed in several independent CHO cell lines, generated using a lentiviral platform...
January 21, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28108985/the-th2-gene-cluster-unraveled-role-of-rhs6
#10
EDITORIAL
Cameron H Flayer, Angela Haczku
Although the transcription factors that regulate T helper (Th) type 2 cytokine production (IL-4, IL-5, and IL-13) are possible novel therapeutic targets, we lack a detailed understanding of the mechanisms that regulate the transcription of these cytokines. In this issue of Allergy, Hwang et al. studied the role of a specific DNA region (a cis-acting element called Rad50 hypersensitive site 6) RHS6, in the development of allergic airway inflammation. RHS6 is found in the Th2 cytokine "locus control region" but its role in activation of the IL-4, IL-5, and IL-13 genes was unknown...
January 20, 2017: Allergy
https://www.readbyqxmd.com/read/28108967/specific-sites-of-metastases-in-invasive-lobular-carcinoma-a-retrospective-cohort-study-of-metastatic-breast-cancer
#11
Masayuki Inoue, Hiroshi Nakagomi, Haruka Nakada, Kazushige Furuya, Kou Ikegame, Hideki Watanabe, Masao Omata, Toshio Oyama
BACKGROUND: Invasive lobular carcinoma (ILC) is known to be the second most common histological type following invasive ductal carcinoma (IDC). Definitive clinical features of ILC are controversial. METHODS: We retrospectively analyzed a cohort of 330 patients with metastatic breast cancer, 303 of IDC, 19 of ILC, and 8 of others. We compared the patient age and tumor-node-metastasis factors, disease-free survival (DFS), estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) expression at the primary site between ILC and IDC...
January 20, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28108953/predictors-of-early-restenosis-after-intracardiac-echocardiography-guided-antegrade-balloon-aortic-valvuloplasty-in-high-risk-or-inoperable-patients
#12
Shinobu Hosokawa, Yoshikazu Hiasa, Akiho Seno, Tatuo Yasuoka, Tomoko Izumi, Riyo Ogura
Antegrade balloon aortic valvuloplasty (BAV) may be more effective than retrograde BAV. However, early restenosis is found inconstantly within three months after BAV. To evaluate the factor of ER after intracardiac echocardiogram (ICE) guided Antegrade BAV, fifty patients with severe aortic stenosis (AS) underwent BAV procedures with ICE. ER was defined as mean aortic valve pressure gradient (PG) >40 mmHg. During one-year follow-up period, 6 patients died and 2 patients underwent aortic valve replacement...
January 20, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28108946/in-vivo-neuroimaging-and-behavioral-correlates-in-a-rat-model-of-chemotherapy-induced-cognitive-dysfunction
#13
Robert L Barry, Nellie E Byun, M Noor Tantawy, Chase A Mackey, George H Wilson, Adam J Stark, Michael P Flom, Laura C Gee, C Chad Quarles
Adjuvant chemotherapy has been used for decades to treat cancer, and it is well known that disruptions in cognitive function and memory are common chemotherapeutic adverse effects. However, studies using neuropsychological metrics have also reported group differences in cognitive function and memory before or without chemotherapy, suggesting that complex factors obscure the true etiology of chemotherapy-induced cognitive dysfunction (CICD) in humans. Therefore, to better understand possible mechanisms of CICD, we explored the effects of CICD in rats through cognition testing using novel object recognition (NOR) and contextual fear conditioning (CFC), and through metabolic neuroimaging via [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET)...
January 20, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28108939/exploration-of-sar-for-novel-2-benzylbenzimidazole-analogs-as-inhibitor-of-transcription-factor-nf-%C3%AE%C2%BAb
#14
PullaReddy Boggu, Eeda Venkateswararao, Manoj Manickam, Youngsoo Kim, Sang-Hun Jung
A novel series of 2-benzylbenzimidazole analogs was designed, synthesized and investigated for their in vitro activities against LPS induced NF-κB inhibition in RAW 264.7 cells using the SEAP assay. Among them, 4-((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)phenol (6e, >100% inhibition at 30 μM, IC50 = 3.0 μM), 4-((5-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)phenol (6j, 96% inhibition at 30 μM, IC50 = 4.0 μM) and 2-((4-(cyclohexylmethoxy)-1H-benzo[d]imidazol-2-yl)methyl)phenol (6k, 95% inhibition at 30 μM, IC50 = 5...
January 20, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28108904/intravitreal-anti-vegf-treatment-for-subretinal-neovascularisation-secondary-to-type-2-idiopathic-juxtafoveolar-telangiectasia
#15
Teresa Barth, Florian Zeman, Horst Helbig, Maria-Andreea Gamulescu
PURPOSE: To assess the long-term outcome of patients with subretinal neovascular membrane (SRNVM) secondary to type 2 idiopathic juxtafoveolar telangiectasia (IJT) receiving intravitreal anti-VEGF (vascular endothelial growth factor) injections. METHODS: A total of 14 eyes of 12 patients treated with intravitreal anti-VEGF for SRNVM related to type 2 IJT were retrospectively assessed. RESULTS: Nine men and 3 women with a mean age of 66 years (SD 12, range 47-87 years) were diagnosed with IJT-related SRNVM...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28108864/is-raf1-protein-from-synechocystis-sp-pcc-6803-really-needed-in-the-cyanobacterial-rubisco-assembly-process
#16
Piotr Kolesinski, Malgorzata Rydzy, Andrzej Szczepaniak
Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is responsible for carbon dioxide conversion during photosynthesis and, therefore, is the most important protein in biomass generation. Modifications of this biocatalyst toward improvements in its properties are hindered by the complicated and not yet fully understood assembly process required for the formation of active holoenzymes. An entire set of auxiliary factors, including chaperonin GroEL/GroES and assembly chaperones RbcX or Rubisco accumulation factor 1 (RAF1), is involved in the folding and subsequent assembly of Rubisco subunits...
January 20, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28108863/genetic-and-environmental-structure-of-dsm-iv-criteria-for-antisocial-personality-disorder-a-twin-study
#17
Tom Rosenström, Eivind Ystrom, Fartein Ask Torvik, Nikolai Olavi Czajkowski, Nathan A Gillespie, Steven H Aggen, Robert F Krueger, Kenneth S Kendler, Ted Reichborn-Kjennerud
Results from previous studies on DSM-IV and DSM-5 Antisocial Personality Disorder (ASPD) have suggested that the construct is etiologically multidimensional. To our knowledge, however, the structure of genetic and environmental influences in ASPD has not been examined using an appropriate range of biometric models and diagnostic interviews. The 7 ASPD criteria (section A) were assessed in a population-based sample of 2794 Norwegian twins by a structured interview for DSM-IV personality disorders. Exploratory analyses were conducted at the phenotypic level...
January 21, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28108841/increased-incidence-of-post-term-delivery-and-cesarean-section-after-frozen-thawed-embryo-transfer-during-a-hormone-replacement-cycle
#18
Kazuki Saito, Kenji Miyado, Kenji Yamatoya, Akira Kuwahara, Eisuke Inoue, Mami Miyado, Maki Fukami, Tomonori Ishikawa, Takakazu Saito, Toshiro Kubota, Hidekazu Saito
PURPOSE: This study aimed to clarify the risks of adverse pregnancy outcomes in patients who conceive singletons after frozen embryo transfer (FET) during a hormone replacement cycle and their offspring. METHODS: A retrospective cohort study was conducted in patients who conceived after FET, based on the Japanese-assisted reproductive technology registry for 2013. The perinatal outcomes in cases with live-born singletons achieved through natural ovulatory cycle FET (NC-FET) (n = 6287) or hormone replacement cycle FET (HRC-FET) (n = 10,235) were compared...
January 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28108828/a-novel-biomarker-based-preoperative-prognostic-grading-system-for-predicting-survival-after-surgery-for-intrahepatic-cholangiocarcinoma
#19
Tomoaki Yoh, Satoru Seo, Etsuro Hatano, Kojiro Taura, Hiroaki Fuji, Yoshinobu Ikeno, Yukihiro Okuda, Kentaro Yasuchika, Toshimi Kaido, Hideaki Okajima, Shinji Uemoto
BACKGROUND: Although treatment strategies for intrahepatic cholangiocarcinoma (ICC) are shifting towards multidisciplinary approaches, preoperative radiographic methods for identifying patients requiring further therapy are unclear. This study was designed to establish a prognostic grading system using preoperatively available objective biomarkers. METHODS: A novel preoperative prognostic grading system for predicting survival after surgery for ICC was developed from multivariate analysis of 134 ICC patients who underwent surgery between 1996 and 2015 using preoperatively available biomarkers...
January 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28108816/decitabine-priming-prior-to-low-dose-chemotherapy-improves-patient-outcomes-in-myelodysplastic-syndromes-raeb-a-retrospective-analysis-vs-chemotherapy-alone
#20
Li Ye, Yanling Ren, Xinping Zhou, Chen Mei, Liya Ma, Xingnong Ye, Juying Wei, Weilai Xu, Haitao Meng, Wenbin Qian, Wenyuan Mai, Yinjun Lou, Gaixiang Xu, Jiejing Qian, Yejiang Lou, Yingwan Luo, Lili Xie, Peipei Lin, Chao Hu, Jie Jin, Hongyan Tong
PURPOSE: The aim of this study was to examine whether decitabine priming prior to low-dose chemotherapeutic regimens could improve outcomes in patients with myelodysplastic syndromes-refractory anemia with excess of blasts (MDS-RAEB). METHODS: The current retrospective analysis included all MDS-RAEB patients receiving idarubicin/cytarabine (IA) or aclacinomycin/cytarabine (AA), with or without decitabine priming during a period from February 2010 to May 2015. Treatment response and toxicity were compared between patients receiving decitabine priming and those who did not...
January 20, 2017: Journal of Cancer Research and Clinical Oncology
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