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https://www.readbyqxmd.com/read/29773572/hemostatic-efficacy-of-pathogen-inactivated-versus-untreated-platelets-a-randomized-controlled-trial
#1
Pieter F van der Meer, Paula F Ypma, Nan van Geloven, Joost A van Hilten, Rinie J van Wordragen-Vlaswinkel, Okke Eissen, Jaap J Zwaginga, MIchael Trus, Erik A M Beckers, Peter Te Boekhorst, Alan Tinmouth, Yulia Lin, Cyrus Hsia, David Lee, Philip J Norris, Raymond P Goodrich, Anneke Brand, Tor Hervig, Nancy M Heddle, Johanna G van der Bom, Jean-Louis H Kerkhoffs
Pathogen inactivation of platelet concentrates reduces the risk of blood-borne infections. However, its effect on platelet function and hemostatic efficacy of transfusion is unclear. We conducted a randomized noninferiority trial comparing the efficacy of pathogen inactivated platelets using riboflavin and ultraviolet B illumination technology (intervention) compared to standard plasma-stored platelets (control) for the prevention of bleeding in patients with hematologic malignancies and thrombocytopenia. The primary outcome parameter was the proportion of transfusion treatment periods in which the patient had grade 2 or higher bleeding as defined by World Health Organization (WHO) criteria...
May 17, 2018: Blood
https://www.readbyqxmd.com/read/29764620/hand-forces-exerted-by-long-term-care-staff-when-pushing-wheelchairs-on-compliant-and-non-compliant-flooring
#2
Chantelle C Lachance, Alexandra M B Korall, Colin M Russell, Fabio Feldman, Stephen N Robinovitch, Dawn C Mackey
Purpose-designed compliant flooring and carpeting have been promoted as a means for reducing fall-related injuries in high-risk environments, such as long-term care. However, it is not known whether these surfaces influence the forces that long-term care staff exert when pushing residents in wheelchairs. We studied 14 direct-care staff who pushed a loaded wheelchair instrumented with a triaxial load cell to test the effects on hand force of flooring overlay (vinyl versus carpet) and flooring subfloor (concrete versus compliant rubber [brand: SmartCells])...
September 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29763523/role-of-basic-pentacysteiene-transcription-factors-in-a-sub-set-of-cytokinin-signaling-responses
#3
Carly M Shanks, Andreas Hecker, Chia-Yi Cheng, Luise Brand, Silvio Collani, Markus Schmid, G Eric Schaller, Dierk Wanke, Klaus Harter, Joseph J Kieber
Cytokinin plays diverse roles in plant growth and development, generally acting by modulating gene transcription in target tissues. The type-B ARR transcription factors have emerged as primary targets of cytokinin signaling and are required for essentially all cytokinin-mediated changes in gene expression. The diversity of cytokinin function is likely imparted by the activity of various transcription factors working with the type-B ARRs to alter specific sets of target genes. One potential set of co-regulators modulating the cytokinin response are the BARLEY B-RECOMBINANT/BASIC PENTACYSTEINE (BBR/BPC) family of plant-specific transcription factors...
May 15, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29757954/consumer-preference-and-attitude-regarding-online-food-products-in-hanoi-vietnam
#4
Anh Kim Dang, Bach Xuan Tran, Cuong Tat Nguyen, Huong Thi Le, Hoa Thi Do, Hinh Duc Nguyen, Long Hoang Nguyen, Tu Huu Nguyen, Hue Thi Mai, Tho Dinh Tran, Chau Ngo, Thuc Thi Minh Vu, Carl A Latkin, Melvyn W B Zhang, Roger C M Ho
This study aimed to examine: (1) how the Internet has changed consumers food-buying behavior and identify its associated factors; (2) consumers' concern about food safety information of online food products. A cross-sectional study was performed from October to December 2015 in Hanoi-a Vietnamese epicenter of food service. One thousand seven hundred and thirty six (1736) customers were randomly chosen from food establishments of 176 communes. Data were collected through face-to-face interviews using structured questionnaires...
May 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29742934/drug-information-association-pharmacovigilance-and-risk-management-strategies-2017-overview-of-the-generic-drug-program-and-surveillance
#5
Howard D Chazin, John R Peters, Debra M Catterson, James L Osterhout, Linda M Forsyth, Jung E Lee, Edward K Kim, Karen B Feibus
The US Food and Drug Administration's (FDA's) generic drug program has dramatically increased the availability of affordable, high quality generic drugs. The foundation of generic drug approvals is a two-tiered regulatory framework of pharmaceutical equivalence and bioequivalence. Intrinsic to both of these is consideration of the clinical relevance of formulation and bioequivalence data to support an inference of therapeutic equivalence, based on clear evidence that there are no significant differences between the generic drug and the brand name drug...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29738810/assessment-of-the-exposure-to-harmful-and-potentially-harmful-constituents-in-healthy-japanese-smokers-using-a-novel-tobacco-vapor-product-compared-with-conventional-cigarettes-and-smoking-abstinence
#6
Dai Yuki
The objectives of this clinical study were to demonstrate a reduction in exposure to selected harmful and potentially harmful constituents (HPHCs), and to assess product use behavior, in Japanese healthy adult smokers who switched to a novel tobacco vapor product (NTV). 60 smokers were randomly assigned for 5 days to either (a) a group who switched to an NTV (n = 20), (b) a group who continued to smoke their own brand of conventional cigarettes (CC, n = 20) or (c) a smoking abstinence group (SA, n = 20)...
May 5, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29733710/generic-price-competition-for-specialty-drugs-too-little-too-late
#7
Ashley L Cole, Stacie B Dusetzina
The case of generic imatinib demonstrates several potential barriers to effective generic price competition for specialty prescription drugs, including fewer market entrants, smaller-than-expected price reductions, shifts in prescribing toward more expensive brand-name treatments, and limited uptake of the generic product.
May 2018: Health Affairs
https://www.readbyqxmd.com/read/29729051/preliminary-assessment-of-stable-nitrogen-and-oxygen-isotopic-composition-of-usgs51-and-usgs52-nitrous-oxide-reference-gases-and-perspectives-on-calibration-needs
#8
Nathaniel E Ostrom, Hasand Gandhi, Tyler B Coplen, Sakae Toyoda, J K Böhlke, Willi A Brand, Karen L Casciotti, Jens Dyckmans, Anette Giesemann, Joachim Mohn, Reinhard Well, Longfei Yu, Naohiro Yoshida
RATIONALE: Despite a long history and growing interest in isotopic analyses of N2 O, there is a lack of isotopically characterized N2 O isotopic reference materials (standards) to enable normalization and reporting of isotope-delta values. Here we report the isotopic characterization of two pure N2 O gas reference materials, USGS51 and USGS52, which are now available for laboratory calibration (https://isotopes.usgs.gov/lab/referencematerials.html). METHODS: A total of 400 sealed borosilicate glass tubes of each N2 O reference gas were prepared from a single gas filling of a high vacuum line...
May 4, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29725242/prospects-for-observing-and-localizing-gravitational-wave-transients-with-advanced-ligo-advanced-virgo-and-kagra
#9
REVIEW
B P Abbott, R Abbott, T D Abbott, M R Abernathy, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, B Allen, A Allocca, P A Altin, A Ananyeva, S B Anderson, W G Anderson, M Ando, S Appert, K Arai, A Araya, M C Araya, J S Areeda, N Arnaud, K G Arun, H Asada, S Ascenzi, G Ashton, Y Aso, M Ast, S M Aston, P Astone, S Atsuta, P Aufmuth, C Aulbert, A Avila-Alvarez, K Awai, S Babak, P Bacon, M K M Bader, L Baiotti, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, J C Barayoga, S E Barclay, B C Barish, D Barker, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, M A Barton, I Bartos, R Bassiri, A Basti, J C Batch, C Baune, V Bavigadda, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, M Belgin, A S Bell, B K Berger, G Bergmann, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, M Boer, G Bogaert, A Bohe, F Bondu, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, V B Braginsky, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, J E Broida, A F Brooks, D A Brown, D D Brown, N M Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, L Cerboni Baiardi, G Cerretani, E Cesarini, S J Chamberlin, M Chan, S Chao, P Charlton, E Chassande-Mottin, B D Cheeseboro, H Y Chen, Y Chen, H-P Cheng, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, S Chung, G Ciani, F Clara, J A Clark, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, A Colla, C G Collette, L Cominsky, M Constancio, L Conti, S J Cooper, T R Corbitt, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, G S Davies, D Davis, E J Daw, B Day, R Day, S De, D DeBra, G Debreczeni, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, T Denker, T Dent, V Dergachev, R De Rosa, R T DeRosa, R DeSalvo, R C Devine, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, S Di Pace, I Di Palma, A Di Virgilio, Z Doctor, K Doi, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, R Douglas, M Dovale Álvarez, T P Downes, M Drago, R W P Drever, J C Driggers, Z Du, M Ducrot, S E Dwyer, K Eda, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, R A Eisenstein, R C Essick, Z Etienne, T Etzel, M Evans, T M Evans, R Everett, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, H Fehrmann, M M Fejer, A Fernández Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, I Fiori, D Fiorucci, R P Fisher, R Flaminio, M Fletcher, H Fong, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, E M Fries, P Fritschel, V V Frolov, Y Fujii, M-K Fujimoto, P Fulda, M Fyffe, H Gabbard, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, S G Gaonkar, F Garufi, G Gaur, V Gayathri, N Gehrels, G Gemme, E Genin, A Gennai, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, A Glaefke, E Goetz, R Goetz, L Gondan, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, P Groot, H Grote, S Grunewald, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, J J Hacker, A Hagiwara, B R Hall, E D Hall, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, M T Hartman, C-J Haster, K Haughian, K Hayama, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, J Henry, A W Heptonstall, M Heurs, S Hild, E Hirose, D Hoak, D Hofman, K Holt, D E Holz, P Hopkins, J Hough, E A Houston, E J Howell, Y M Hu, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, N Indik, D R Ingram, R Inta, K Ioka, H N Isa, J-M Isac, M Isi, T Isogai, Y Itoh, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, T Kagawa, T Kajita, M Kakizaki, C V Kalaghatgi, V Kalogera, M Kamiizumi, N Kanda, S Kandhasamy, S Kanemura, M Kaneyama, G Kang, J B Kanner, S Karki, K S Karvinen, M Kasprzack, Y Kataoka, E Katsavounidis, W Katzman, S Kaufer, T Kaur, K Kawabe, N Kawai, S Kawamura, F Kéfélian, D Keitel, D B Kelley, R Kennedy, J S Key, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, C Kim, H Kim, J C Kim, J Kim, W Kim, Y-M Kim, S J Kimbrell, N Kimura, E J King, P J King, R Kirchhoff, J S Kissel, B Klein, L Kleybolte, S Klimenko, P Koch, S M Koehlenbeck, Y Kojima, K Kokeyama, S Koley, K Komori, V Kondrashov, A Kontos, M Korobko, W Z Korth, K Kotake, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, Rahul Kumar, Rakesh Kumar, L Kuo, K Kuroda, A Kutynia, Y Kuwahara, B D Lackey, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, E O Lebigot, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, M Leonardi, J R Leong, N Leroy, N Letendre, Y Levin, T G F Li, A Libson, T B Littenberg, J Liu, N A Lockerbie, A L Lombardi, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Lück, A P Lundgren, R Lynch, Y Ma, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, F Magaña-Sandoval, E Majorana, I Maksimovic, V Malvezzi, N Man, V Mandic, V Mangano, S Mano, G L Mansell, M Manske, M Mantovani, F Marchesoni, M Marchio, F Marion, S Márka, Z Márka, A S Markosyan, E Maros, F Martelli, L Martellini, I W Martin, D V Martynov, K Mason, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, F Matichard, L Matone, N Matsumoto, F Matsushima, N Mavalvala, N Mazumder, R McCarthy, D E McClelland, S McCormick, C McGrath, S C McGuire, G McIntyre, J McIver, D J McManus, T McRae, S T McWilliams, D Meacher, G D Meadors, J Meidam, A Melatos, G Mendell, D Mendoza-Gandara, R A Mercer, E L Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdorff, P M Meyers, F Mezzani, H Miao, C Michel, Y Michimura, H Middleton, E E Mikhailov, L Milano, A L Miller, A Miller, B B Miller, J Miller, M Millhouse, Y Minenkov, J Ming, S Mirshekari, C Mishra, V P Mitrofanov, G Mitselmakher, R Mittleman, O Miyakawa, A Miyamoto, T Miyamoto, S Miyoki, A Moggi, M Mohan, S R P Mohapatra, M Montani, B C Moore, C J Moore, D Moraru, G Moreno, W Morii, S Morisaki, Y Moriwaki, S R Morriss, B Mours, C M Mow-Lowry, G Mueller, A W Muir, Arunava Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, E A M Muniz, P G Murray, A Mytidis, S Nagano, K Nakamura, T Nakamura, H Nakano, Masaya Nakano, Masayuki Nakano, K Nakao, K Napier, I Nardecchia, T Narikawa, L Naticchioni, G Nelemans, T J N Nelson, M Neri, M Nery, A Neunzert, J M Newport, G Newton, T T Nguyen, W-T Ni, A B Nielsen, S Nissanke, A Nitz, A Noack, F Nocera, D Nolting, M E N Normandin, L K Nuttall, J Oberling, E Ochsner, E Oelker, G H Ogin, J J Oh, S H Oh, M Ohashi, N Ohishi, M Ohkawa, F Ohme, K Okutomi, M Oliver, K Ono, Y Ono, K Oohara, P Oppermann, Richard J Oram, B O'Reilly, R O'Shaughnessy, D J Ottaway, H Overmier, B J Owen, A E Pace, J Page, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, H Pan, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, H R Paris, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, B Patricelli, B L Pearlstone, M Pedraza, R Pedurand, L Pekowsky, A Pele, F E Peña Arellano, S Penn, C J Perez, A Perreca, L M Perri, H P Pfeiffer, M Phelps, O J Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pitkin, M Poe, R Poggiani, P Popolizio, A Post, J Powell, J Prasad, J W W Pratt, V Predoi, T Prestegard, M Prijatelj, M Principe, S Privitera, G A Prodi, L G Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, J Qin, S Qiu, V Quetschke, E A Quintero, R Quitzow-James, F J Raab, D S Rabeling, H Radkins, P Raffai, S Raja, C Rajan, M Rakhmanov, P Rapagnani, V Raymond, M Razzano, V Re, J Read, T Regimbau, L Rei, S Reid, D H Reitze, H Rew, S D Reyes, E Rhoades, F Ricci, K Riles, M Rizzo, N A Robertson, R Robie, F Robinet, A Rocchi, L Rolland, J G Rollins, V J Roma, R Romano, J H Romie, D Rosińska, S Rowan, A Rüdiger, P Ruggi, K Ryan, S Sachdev, T Sadecki, L Sadeghian, N Sago, M Saijo, Y Saito, K Sakai, M Sakellariadou, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, L M Sampson, E J Sanchez, V Sandberg, J R Sanders, Y Sasaki, B Sassolas, B S Sathyaprakash, S Sato, T Sato, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, J Scheuer, E Schmidt, J Schmidt, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B F Schutz, S G Schwalbe, J Scott, S M Scott, T Sekiguchi, Y Sekiguchi, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, Y Setyawati, D A Shaddock, T J Shaffer, M S Shahriar, B Shapiro, P Shawhan, A Sheperd, M Shibata, Y Shikano, T Shimoda, A Shoda, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, M Sieniawska, D Sigg, A D Silva, A Singer, L P Singer, A Singh, R Singh, A Singhal, A M Sintes, B J J Slagmolen, B Smith, J R Smith, R J E Smith, K Somiya, E J Son, B Sorazu, F Sorrentino, T Souradeep, A P Spencer, A K Srivastava, A Staley, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, B C Stephens, S P Stevenson, R Stone, K A Strain, N Straniero, G Stratta, S E Strigin, R Sturani, A L Stuver, Y Sugimoto, T Z Summerscales, L Sun, S Sunil, P J Sutton, T Suzuki, B L Swinkels, M J Szczepańczyk, M Tacca, H Tagoshi, S Takada, H Takahashi, R Takahashi, A Takamori, D Talukder, H Tanaka, K Tanaka, T Tanaka, D B Tanner, M Tápai, A Taracchini, D Tatsumi, R Taylor, S Telada, T Theeg, E G Thomas, M Thomas, P Thomas, K A Thorne, E Thrane, T Tippens, S Tiwari, V Tiwari, K V Tokmakov, K Toland, T Tomaru, C Tomlinson, M Tonelli, Z Tornasi, C I Torrie, D Töyrä, F Travasso, G Traylor, D Trifirò, J Trinastic, M C Tringali, L Trozzo, M Tse, R Tso, K Tsubono, T Tsuzuki, M Turconi, D Tuyenbayev, T Uchiyama, T Uehara, S Ueki, K Ueno, D Ugolini, C S Unnikrishnan, A L Urban, T Ushiba, S A Usman, H Vahlbruch, G Vajente, G Valdes, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, J V van Heijningen, M H P M van Putten, A A van Veggel, M Vardaro, V Varma, S Vass, M Vasúth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, G Venugopalan, D Verkindt, F Vetrano, A Viceré, A D Viets, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, D V Voss, W D Vousden, S P Vyatchanin, A R Wade, L E Wade, M Wade, T Wakamatsu, M Walker, L Wallace, S Walsh, G Wang, H Wang, M Wang, Y Wang, R L Ward, J Warner, M Was, J Watchi, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, L Wen, P Weßels, T Westphal, K Wette, J T Whelan, B F Whiting, C Whittle, D Williams, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Woehler, J Worden, J L Wright, D S Wu, G Wu, W Yam, H Yamamoto, K Yamamoto, T Yamamoto, C C Yancey, K Yano, M J Yap, J Yokoyama, T Yokozawa, T H Yoon, Hang Yu, Haocun Yu, H Yuzurihara, M Yvert, A Zadrożny, L Zangrando, M Zanolin, S Zeidler, J-P Zendri, M Zevin, L Zhang, M Zhang, T Zhang, Y Zhang, C Zhao, M Zhou, Z Zhou, S J Zhu, X J Zhu, M E Zucker, J Zweizig
We present possible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community to facilitate planning for multi-messenger astronomy with gravitational waves. We estimate the sensitivity of the network to transient gravitational-wave signals, and study the capability of the network to determine the sky location of the source. We report our findings for gravitational-wave transients, with particular focus on gravitational-wave signals from the inspiral of binary neutron star systems, which are the most promising targets for multi-messenger astronomy...
2018: Living Reviews in Relativity
https://www.readbyqxmd.com/read/29721705/knowledge-of-adverse-drug-reaction-reporting-and-the-pharmacovigilance-of-biological-medicines-a-survey-of-healthcare-professionals-in-ireland
#10
J O'Callaghan, B T Griffin, J M Morris, Margaret Bermingham
BACKGROUND: In Europe, changes to pharmacovigilance legislation, which include additional monitoring of medicines, aim to optimise adverse drug reaction (ADR) reporting systems. The legislation also makes provisions related to the traceability of biological medicines. OBJECTIVE: The objective of this study was to assess (i) knowledge and general experience of ADR reporting, (ii) knowledge, behaviours, and attitudes related to the pharmacovigilance of biologicals, and (iii) awareness of additional monitoring among healthcare professionals (HCPs) in Ireland...
May 2, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/29720350/hospitalizations-for-asthma-exacerbation-in-chilean-children-a-multicenter-observational-study
#11
A M Herrera, P Brand, G Cavada, A Koppmann, M Rivas, J Mackenney, H Sepúlveda, M E Wevar, L Cruzat, S Soto, M A Pérez, A León, I Contreras, C Alvarez, B Walker, C Flores, V Lezana, C Garrido, M E Herrera, A Rojas, C Andrades, E Chala, R A Martínez, M Vega, J A Perillán, H Seguel, I Przybyzsweski
BACKGROUND: Asthma hospitalization rates in Chilean children have increased in the last 14 years, but little is known about the factors associated with this. OBJECTIVE: Describe clinical characteristics of children hospitalized for asthma exacerbation. METHODS: Observational prospective cohort study in 14 hospitals. Over a one-year period, children five years of age or older hospitalized with asthma exacerbation were eligible for inclusion...
April 29, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29718161/outcome-of-long-benign-esophageal-strictures-undergoing-endoscopictherapy-a-tertiary-center-experience
#12
M Pang, M J Bartel, E C Brand, B Brahmbhatt, K Patel, C R Simons-Linares, H C Wolfsen, M Raimondo, M B Wallace, T A Woodward
Complex benign esophageal strictures are defined by length (≥2 cm), small diameter, and stricture angulation or tortuosity. The long-term course of complex esophageal strictures based on length is currently unclear. We suspect that the esophageal stricture length might impact the effectiveness of endoscopic dilation therapy. We performed a retrospective study of all benign esophageal strictures of 2 cm or longer treated at a single center between July 1, 2010, and May 31, 2014. Primary outcomes were changed in dysphagia score at the end of follow-up compared to first dilation at our facility and the need for gastrostomy placement or esophagectomy during follow-up...
May 1, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29714570/outdated-prescription-drug-labeling-how-fda-approved-prescribing-information-lags-behind-real-world-clinical-practice
#13
Michael B Shea, Mark Stewart, Hugo Van Dyke, Linda Ostermann, Jeff Allen, Ellen Sigal
BACKGROUND: Prescription drug labeling is an authoritative source of information that guides the safe and effective use of approved medications. In many instances, however, labeling may fail to be updated as new information about drug efficacy emerges in the postmarket setting. When labeling becomes outdated, it loses its value for prescribers and undermines a core part of the FDA's mission to communicate accurate and reliable information to patients and physicians. METHODS: We compared the number of drug uses indicated on product labels to the number of uses contained in a leading drug compendium for 43 cancer drugs approved between 1999 and 2011...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29706522/the-association-between-diabetes-comorbidities-body-mass-index-and-all-cause-and-cause-specific-mortality-among-women-with-endometrial-cancer
#14
C M Nagle, E J Crosbie, A Brand, A Obermair, M K Oehler, M Quinn, Y Leung, A B Spurdle, P M Webb
OBJECTIVE: Although endometrial cancer (EC) is associated with relatively good survival rates overall, women diagnosed with high-risk subtypes have poor outcomes. We examined the relationship between lifestyle factors and subsequent all-cause, cancer-specific and non-cancer related survival. METHODS: In a cohort of 1359 Australian women diagnosed with incident EC between 2005 and 2007 pre-diagnostic information was collected by interview at recruitment. Clinical and survival information was abstracted from women's medical records, supplemented by linkage to the Australian National Death Index...
April 26, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29705260/distal-attachment-devices-in-colonoscopy-should-they-routinely-be-added
#15
EDITORIAL
Eelco C Brand, Michael B Wallace
No abstract text is available yet for this article.
April 26, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29700473/an-analytical-framework-for-whole-genome-sequence-association-studies-and-its-implications-for-autism-spectrum-disorder
#16
Donna M Werling, Harrison Brand, Joon-Yong An, Matthew R Stone, Lingxue Zhu, Joseph T Glessner, Ryan L Collins, Shan Dong, Ryan M Layer, Eirene Markenscoff-Papadimitriou, Andrew Farrell, Grace B Schwartz, Harold Z Wang, Benjamin B Currall, Xuefang Zhao, Jeanselle Dea, Clif Duhn, Carolyn A Erdman, Michael C Gilson, Rachita Yadav, Robert E Handsaker, Seva Kashin, Lambertus Klei, Jeffrey D Mandell, Tomasz J Nowakowski, Yuwen Liu, Sirisha Pochareddy, Louw Smith, Michael F Walker, Matthew J Waterman, Xin He, Arnold R Kriegstein, John L Rubenstein, Nenad Sestan, Steven A McCarroll, Benjamin M Neale, Hilary Coon, A Jeremy Willsey, Joseph D Buxbaum, Mark J Daly, Matthew W State, Aaron R Quinlan, Gabor T Marth, Kathryn Roeder, Bernie Devlin, Michael E Talkowski, Stephan J Sanders
Genomic association studies of common or rare protein-coding variation have established robust statistical approaches to account for multiple testing. Here we present a comparable framework to evaluate rare and de novo noncoding single-nucleotide variants, insertion/deletions, and all classes of structural variation from whole-genome sequencing (WGS). Integrating genomic annotations at the level of nucleotides, genes, and regulatory regions, we define 51,801 annotation categories. Analyses of 519 autism spectrum disorder families did not identify association with any categories after correction for 4,123 effective tests...
April 26, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29670710/effect-of-the-lack-of-primary-stability-in-the-survival-of-dental-implants
#17
Carlos Cobo-Vázquez, David Reininger, Pedro Molinero-Mourelle, José González-Serrano, Blanca Guisado-Moya, Juan López-Quiles
Background: The survival of dental implants has been linked to primary stability. The aim of this study is to analyse the factors that influence the survival of dental implants placed without primary stability. Material and Methods: A cohort study of implants placed without primary stability was carried out between September 2011 and July 2016. All cases with registered information on the patient and surgical intervention were used. Cases that did not have a 12-month follow-up after implant placement were excluded...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29670093/wild-ducks-excrete-highly-pathogenic-avian-influenza-virus-h5n8-2014-2015-without-clinical-or-pathological-evidence-of-disease
#18
Judith M A van den Brand, Josanne H Verhagen, Edwin J B Veldhuis Kroeze, Marco W G van de Bildt, Rogier Bodewes, Sander Herfst, Mathilde Richard, Pascal Lexmond, Theo M Bestebroer, Ron A M Fouchier, Thijs Kuiken
Highly pathogenic avian influenza (HPAI) is essentially a poultry disease. Wild birds have traditionally not been involved in its spread, but the epidemiology of HPAI has changed in recent years. After its emergence in southeastern Asia in 1996, H5 HPAI virus of the Goose/Guangdong lineage has evolved into several sub-lineages, some of which have spread over thousands of kilometers via long-distance migration of wild waterbirds. In order to determine whether the virus is adapting to wild waterbirds, we experimentally inoculated the HPAI H5N8 virus clade 2...
April 18, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29669919/mutations-in-the-pancreatic-secretory-enzymes-cpa1-and-cpb1-are-associated-with-pancreatic-cancer
#19
Koji Tamura, Jun Yu, Tatsuo Hata, Masaya Suenaga, Koji Shindo, Toshiya Abe, Anne MacGregor-Das, Michael Borges, Christopher L Wolfgang, Matthew J Weiss, Jin He, Marcia Irene Canto, Gloria M Petersen, Steven Gallinger, Sapna Syngal, Randall E Brand, Anil Rustgi, Sara H Olson, Elena Stoffel, Michele L Cote, George Zogopoulos, James B Potash, Fernando S Goes, Richard W McCombie, Peter P Zandi, Mehdi Pirooznia, Melissa Kramer, Jennifer Parla, James R Eshleman, Nicholas J Roberts, Ralph H Hruban, Alison Patricia Klein, Michael Goggins
To evaluate whether germline variants in genes encoding pancreatic secretory enzymes contribute to pancreatic cancer susceptibility, we sequenced the coding regions of CPB1 and other genes encoding pancreatic secretory enzymes and known pancreatitis susceptibility genes ( PRSS1 , CPA1 , CTRC , and SPINK1 ) in a hospital series of pancreatic cancer cases and controls. Variants in CPB1 , CPA1 (encoding carboxypeptidase B1 and A1), and CTRC were evaluated in a second set of cases with familial pancreatic cancer and controls...
April 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29628740/total-and-soluble-fluoride-concentration-present-in-various-commercial-brands-of-children-toothpastes-available-in-saudi-arabia-a-pilot-study
#20
Imran Farooq, Saqib Ali, Khalifa Sulaiman Al-Khalifa, Khalid Alhooshani
Objective: The aim of this pilot study was to perform chemical analysis and investigate the total and soluble fluoride concentrations in various brands of children toothpastes. Materials and methods: Three samples of five different commercial brands of children toothpastes were collected and divided into five groups; group A - Biorepair Oral Care toothpaste containing no fluoride (control), group B - Signal Kids Strawberry toothpaste having 500 ppm fluoride, group C - Aquafresh Milk Teeth toothpaste having 500 ppm fluoride, group D - Aquafresh Little Teeth toothpaste having 500 ppm fluoride, and group E - Siwak F Junior having 400 ppm F...
April 2018: Saudi Dental Journal
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