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https://www.readbyqxmd.com/read/27932218/bisphenol-a-bpa-in-the-serum-of-pet-dogs-following-short-term-consumption-of-canned-dog-food-and-potential-health-consequences-of-exposure-to-bpa
#1
Zoe L Koestel, Robert C Backus, Kaoru Tsuruta, William G Spollen, Sarah A Johnson, Angela B Javurek, Mark R Ellersieck, Charles E Wiedmeyer, Kurunthachalam Kannan, Jingchuan Xue, Nathan J Bivens, Scott A Givan, Cheryl S Rosenfeld
Bisphenol A (BPA) is a widely present endocrine disruptor chemical found in many household items. Moreover, this chemical can bioaccumulate in various terrestrial and aquatic sources; thereby ensuring continual exposure of animals and humans. For most species, including humans, diet is considered the primary route of exposure. However, there has been little investigation whether commercial-brands of dog foods contain BPA and potential health ramifications of BPA-dietary exposure in dogs. We sought to determine BPA content within dog food, whether short-term consumption of these diets increases serum concentrations of BPA, and potential health consequences, as assessed by potential hematological, serum chemistry, cortisol, DNA methylation, and gut microbiome changes, in dogs associated with short-term dietary exposure to BPA...
December 5, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27924187/evaluating-outcomes-in-patients-with-overactive-bladder-within-an-integrated-healthcare-delivery-system-using-a-treatment-patterns-analyzer
#2
Daniel B Ng, Melissa McCart, Christopher Klein, Chelsey Campbell, Robert Schoenhaus, Todd Berner
BACKGROUND: Overactive bladder (OAB) is a relatively common disease that has been linked to a variety of comorbidities, reductions in quality of life, and increased healthcare costs. Antimuscarinic agents are the standard of care among pharmacologic treatments for OAB, but these drugs are linked to high levels of anticholinergic burden, especially in the elderly. OBJECTIVE: To demonstrate how efficient data analysis can be used to identify gaps in care as a result of improvement strategies for OAB within an integrated healthcare delivery system setting...
September 2016: American Health & Drug Benefits
https://www.readbyqxmd.com/read/27920746/-worse-but-ours-or-better-but-theirs-the-role-of-implicit-consumer-ethnocentrism-ice-in-product-preference
#3
Dominika Maison, Norbert Maliszewski
The goal of this project was to investigate whether consumer ethnocentrism is purely conscious mechanism based on ideology, as suggested by Shimp and Sharma (1987), or rather is an automatic, unconscious process. The aim of the project was an introduction of the Implicit Consumer Ethnocentrism (ICE) concept, measured by the Implicit Association Test (IAT). The goal of the four studies conducted was to investigate the following issues: (a) whether ICE - an automatic mechanism underlying the preference for local products over foreign - this could be observed next to the more ideologically based classic consumer ethnocentrism; (b) what happens when the consumer's automatic preference for local products (ICE) is confronted by objective evidence of the superiority of foreign products or by the inferiority of local products...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27920198/effects-of-breeder-age-strain-and-eggshell-temperature-on-nutrient-metabolism-of-broiler-embryos
#4
A Nangsuay, R Meijerhof, I van den Anker, M J W Heetkamp, B Kemp, H van den Brand
Breeder age and broiler strain influence the availability of nutrients and oxygen through yolk size and eggshell conductance, and the effects of these egg characteristics on nutrient metabolism might be influenced by eggshell temperature (EST). This study aims to determine effects of breeder age, strain, and EST on nutrient metabolism of embryos. A study was designed as a 2 × 2 × 2 factorial arrangement using four batches of in total 4,464 hatching eggs of 2 flock ages at 29 to 30 wk (young) and 54 to 55 wk (old) of Ross 308 and Cobb 500...
December 5, 2016: Poultry Science
https://www.readbyqxmd.com/read/27903312/more-than-two-thirds-of-dietary-iodine-in-children-in-northern-ghana-is-obtained-from-bouillon-cubes-containing-iodized-salt
#5
Abdul-Razak Abizari, Susanne Dold, Roland Kupka, Michael B Zimmermann
OBJECTIVE: Bouillon cubes are widely consumed by poor households in sub-Saharan Africa. Because their main ingredient is salt, bouillon cubes could be a good source of iodine if iodized salt is used in their production and if their consumption by target groups is high. Our objective was to measure the iodine content of bouillon cubes, estimate their daily intake in school-aged children and evaluate their potential contribution to iodine intakes. DESIGN: In a cross-sectional study, we measured urinary iodine concentrations (UIC) and estimated total daily iodine intakes...
December 1, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27895098/brain-aluminium-accumulation-and-oxidative-stress-in-the-presence-of-calcium-silicate-dental-cements
#6
K Demirkaya, B Can Demirdöğen, Z Öncel Torun, O Erdem, E Çırak, Y M Tunca
Mineral trioxide aggregate (MTA) is a calcium silicate dental cement used for various applications in dentistry. This study was undertaken to test whether the presence of three commercial brands of calcium silicate dental cements in the dental extraction socket of rats would affect the brain aluminium (Al) levels and oxidative stress parameters. Right upper incisor was extracted and polyethylene tubes filled with MTA Angelus, MTA Fillapex or Theracal LC, or left empty for the control group, were inserted into the extraction socket...
November 27, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27889164/multilocus-sequence-type-profiles-of-bacillus-cereus-isolates-from-infant-formula-in-china
#7
Yong Yang, Xiaofeng Yu, Li Zhan, Jiancai Chen, Yunyi Zhang, Junyan Zhang, Honghu Chen, Zheng Zhang, Yanjun Zhang, Yiyu Lu, Lingling Mei
Bacillus cereus sensu stricto is an opportunistic foodborne pathogen. The multilocus sequence type (MLST) of 74 B. cereus isolated from 513 non-random infant formula in China was analyzed. Of 64 sequence types (STs) detected, 50 STs and 6 alleles were newly found in PubMLST database. All isolates except for one singleton (ST-1049), were classified into 7 clonal complexes (CC) by BURST (n-4), in which CC1 with core ancestral clone ST-26 was the largest group including 86% isolates, and CC2, 3, 9, 10 and 13 were first reported in China...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27876365/midyear-commentary-on-trends-in-drug-delivery-and-clinical-translational-medicine-growth-in-biosimilar-complex-injectable-drug-formulation-products-within-evolving-collaborative-regulatory-interagency-fda-ftc-and-doj-practices-and-enforcement
#8
Rodney J Y Ho
Before the 2009 Biologics Price Competition and Innovation Act that enabled the U.S. Federal Drug Administration (FDA) to create the 351(k) Biologic License Application-an abbreviated biosimilar approval process, FDA approved follow-on biomolecule products such as beta-interferon, glucagon, hyaluronidase, and somatropin (human growth hormone) under varying and evolving rules. With the 351(k) Biologic License Application biosimilar approval process in place, currently, there are 4 (licensed in 2015-2016) biosimilars available, namely Neupogen (filgrastim; $1 B/y), Humira (adalumumab; $14...
November 19, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27868200/impact-of-copayment-changes-on-children-s-albuterol-inhaler-use-and-costs-after-the-clean-air-act-chlorofluorocarbon-ban
#9
Alison A Galbraith, Vicki Fung, Lingling Li, Melissa G Butler, James D Nordin, John Hsu, David Smith, William M Vollmer, Tracy A Lieu, Stephen B Soumerai, Ann Chen Wu
OBJECTIVE: To examine changes in children's albuterol use and out-of-pocket (OOP) costs in response to increased copayments after the Food and Drug Administration banned inhalers with chlorofluorocarbon (CFC) propellants. SETTING: Four health maintenance organizations (HMOs), two that increased copayments for albuterol inhalers that went from generic CFC-containing to branded CFC-free versions, and two that retained generic copayments for CFC-free inhalers (controls)...
November 20, 2016: Health Services Research
https://www.readbyqxmd.com/read/27855918/determination-of-bpa-bpb-bpf-badge-and-bfdge-in-canned-energy-drinks-by-molecularly-imprinted-polymer-cleaning-up-and-uplc-with-fluorescence-detection
#10
Pasquale Gallo, Ilaria Di Marco Pisciottano, Francesco Esposito, Evelina Fasano, Gelsomina Scognamiglio, Gustavo Damiano Mita, Teresa Cirillo
A new method for simultaneous determination of five bisphenols in canned energy drinks by UPLC with fluorescence detection, after clean up on molecularly imprinted polymers, is herein described. The method was validated at two concentration levels, calculating trueness, repeatability and within-laboratory reproducibility, specificity, linearity of detector response, the limits of quantifications and the limits of detection for each bisphenol. The method is specific, reliable and very sensitive, allowing for determination of bisphenol F diglycidyl ether (BFDGE), bisphenol A (BPA), bisphenol B (BPB), bisphenol F (BPF) and bisphenol A diglycidyl ether (BADGE) down to 0...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27846035/ibd-live-case-series-case-6-persistent-skin-lesions-in-a-patient-with-crohn-s-disease-you-hear-hoof-beats-and-discover-a-zebra
#11
Dhyan Rajan, Julia B Greer, Miguel D Regueiro, Leonard Baidoo, David G Binion, Hans H Herfarth, Corey A Siegel, Douglas J Hartman, Francis A Farraye, Ioannis E Koutroubakis, Myron H Brand, Emmanuelle D Williams, Alka Goyal, Raymond K Cross
No abstract text is available yet for this article.
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27831948/hiv-surveillance-combining-an-assay-for-identification-of-very-recent-infection-and-phylogenetic-analyses-on-dried-spots
#12
Denys Brand, Jean Capsec, Antoine Chaillon, Françoise Cazein, Stéphane Le Vu, Alain Moreau, Josiane Pillonel, Sylvie Brunet, Damien Thierry, Leslie Guillon-Grammatico, Florence Lot, Francis Barin
BACKGROUND: Transmitted/founder (T/F) viruses isolated at the early stage of infection are indicators of the variants that are spreading within a population. The French reporting system for new HIV diagnoses is linked to a virological surveillance using dried serum spots (DSS). METHODS: We combined an immunoassay for very recent infection (VRI < 31 days) to a phylogenetic analysis of T/F viruses and sociodemographic information to analyze the dynamics of the HIV-1 epidemic during a 3-year period...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831717/it-s-complicated-examining-smokers-relationships-with-their-cigarette-brands
#13
Sarah E Johnson, Blair N Coleman, Carol L Schmitt
Despite increased restrictions and taxes, decreased social acceptability, and widespread awareness of the harms of tobacco use, many in the U.S. continue to smoke cigarettes. Thus, understanding smokers' attitudes and motivations remains an important goal. This study adopts the consumer psychology concept of brand relationship to provide a new lens through which to examine smokers' attitudes about their cigarette use. Twelve focus groups (N = 143) were conducted with adult cigarette smokers from September to November, 2013...
November 10, 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/27816692/il-6-a-central-acute-phase-mediator-as-an-early-biomarker-for-exposure-to-zinc-based-metal-fumes
#14
R Baumann, S Joraslafsky, A Markert, I Rack, S Davatgarbenam, V Kossack, B Gerhards, T Kraus, P Brand, M Gube
AIMS: Systemic C-reactive protein (CRP) increases 1day after short-term inhalation of welding fumes containing zinc and/or copper. The aim of the current study was to find further, possibly earlier systemic biomarkers after inhalation of different welding fumes containing zinc and traces of aluminum, with or without copper, as these metal combinations become more common in modern joining technology. METHODS: The study group consisted of 15 non-smoking male volunteers with healthy lung function data and without any occupational metal fume exposure...
December 12, 2016: Toxicology
https://www.readbyqxmd.com/read/27816090/can-we-trust-knee-meniscus-studies-one-way-crossover-confounds-intent-to-treat-statistical-methods
#15
EDITORIAL
James H Lubowitz, Ralph B D'Agostino, Matthew T Provencher, Michael J Rossi, Jefferson C Brand
Randomized controlled studies have a high level of evidence. However, some patients are not treated in the manner to which they were randomized and actually switch to the alternative treatment (crossover). In such cases, "intent-to-treat" statistical methods require that such a switch be ignored, resulting in bias. Thus, the study conclusions could be wrong. This bias is a common problem in the knee meniscus literature.
November 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27809484/characterizing-protein-glycosylation-through-on-chip-glycan-modification-and-probing
#16
Bryan S Reatini, Elliot Ensink, Brian Liau, Jessica Y Sinha, Thomas W Powers, Katie Partyka, Marshall Bern, Randall E Brand, Pauline Mary Rudd, Doron Kletter, Richard R Drake, Brian B Haab
Glycans are critical to protein biology and are useful as disease biomarkers. Many studies of glycans rely on clinical specimens, but the low amount of sample available for some specimens limits the experimental options. Here we present a method to obtain information about protein glycosylation using a minimal amount of protein. We treat proteins that were captured or directly spotted in small microarrays (2.2 x 2.2 mm) with exoglycosidases to successively expose underlying features, and then we probe the native or exposed features using a panel of lectins or glycan-binding reagents...
November 3, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27805473/are-disease-awareness-links-on-prescription-drug-websites-misleading-a-randomized-study
#17
Helen W Sullivan, Amie C O'Donoghue, Douglas J Rupert, Jessica Fitts Willoughby, Jacqueline B Amoozegar, Kathryn J Aikin
We sought to determine whether links from branded prescription drug websites to websites containing disease information mislead participants about drug benefits and whether nonsponsorship disclosures diminish this potential effect. We randomly assigned online panelists with depression (N = 1,071) to view a fictitious prescription drug website that had (a) no link to a disease information website (control), (b) a link with no disclosure, (c) a link with a simple nonsponsorship disclosure, or (d) a link with a detailed nonsponsorship disclosure...
November 2, 2016: Journal of Health Communication
https://www.readbyqxmd.com/read/27801950/use-of-the-control-of-allergic-rhinitis-and-asthma-test-caratkids-in-children-and-adolescents-validation-in-dutch
#18
J A M Emons, B M J Flokstra-de Blok, C de Jong, T van der Molen, H K Brand, N J T Arends, R Amaral, J A Fonseca, R Gerth van Wijk
BACKGROUND: Allergic rhinitis and asthma are common and closely related diseases. Recently, a Portugese questionnaire has been developed 'The Control of Allergic Rhinitis and Asthma Test' (CARATkids) that measures disease control of both diseases in children. This study aims to validate the CARATkids in Dutch children and for the first time in adolescents. In addition, to calculate the minimal clinically important difference (MCID). METHODS: A prospective observational study was conducted in an outpatient clinic...
November 1, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27800567/investigation-of-the-dissolution-profile-of-gliclazide-modified-release-tablets-using-different-apparatuses-and-dissolution-conditions
#19
K K S Skripnik, M K Riekes, B R Pezzini, S G Cardoso, H K Stulzer
In the absence of an official dissolution method for modified-release tablets of gliclazide, dissolution parameters, such as apparatuses (1, 2, and 3), rotation speeds, pH, and composition of the dissolution medium were investigated. The results show that although the drug presents a pH-mediated solubility (pH 7.0 > 6.8 > 6.4 > 6.0 > 5.5 > 4.5), the in vitro release of the studied tablets was not dependent on this parameter, despite of the apparatus tested. On the other hand, the rotation speed demonstrated a greater influence (100 rpm >50 rpm)...
October 31, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27799968/evaluation-of-aryoseven-safety-recombinant-activated-factor-vii-in-patients-with-bleeding-disorders-an-observational-post-marketing-surveillance-study
#20
Gholamreza Toogeh, Hassan Abolghasemi, Peyman Eshghi, Mohammadreza Managhchi, Mohammadreza Shaverdi-Niasari, Katayoon Karimi, Samin Roostaei, Neda Emran, Alireza Abdollahi
BACKGROUND: Recombinant activated factor VII induces hemostasis in patients with coagulopathy disorders. AryoSeven™ as a safe Iranian Recombinant activated factor VII has been available on our market. This study was performed to establish the safety of AryoSeven on patients with coagulopathy disorder. METHODS: This single-center, descriptive, cross sectional study was carried out in Thrombus and Homeostasis Research Center ValiAsr Hospital during 2013-2014. Fifty one patients with bleeding disorders who received at least one dose of Aryoseven were enrolled...
2016: Iranian Journal of Pathology
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