keyword
https://read.qxmd.com/read/38492400/change-characteristics-bacteria-host-and-spread-risks-of-bioaerosol-args-mges-from-different-stages-in-sewage-and-sludge-treatment-process
#1
JOURNAL ARTICLE
Yanjie Wang, Kai Yang, Lin Li, Liying Yang, Song Zhang, Fangfang Yu, Linlin Hua
The spread of antibiotic resistance genes (ARGs) in the atmospheric environment has seriously threatened human health. Wastewater treatment plants (WWTPs) are an important source of aerosol ARGs. A large WWTP, including sewage treatment process (SWP) and sludge treatment process (SDP), was selected in North China for sampling in this study. The content of ARGs, mobile genetic elements (MGEs), and bacterial genera in sewage/sludge and aerosols from different process stages was detected. The possible correlation between ARGs/ MGEs and bacteria was analyzed...
March 13, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38461214/bacteriophage-therapy-for-the-treatment-of-mycobacterium-tuberculosis-infections-in-humanized-mice
#2
JOURNAL ARTICLE
Fan Yang, Alireza Labani-Motlagh, Jose Alejandro Bohorquez, Josimar Dornelas Moreira, Danish Ansari, Sahil Patel, Fabrizio Spagnolo, Jon Florence, Abhinav Vankayalapati, Tsuyoshi Sakai, Osamu Sato, Mitsuo Ikebe, Ramakrishna Vankayalapati, John J Dennehy, Buka Samten, Guohua Yi
The continuing emergence of new strains of antibiotic-resistant bacteria has renewed interest in phage therapy; however, there has been limited progress in applying phage therapy to multi-drug resistant Mycobacterium tuberculosis (Mtb) infections. In this study, we show that bacteriophage strains D29 and DS6A can efficiently lyse Mtb H37Rv in 7H10 agar plates. However, only phage DS6A efficiently kills H37Rv in liquid culture and in Mtb-infected human primary macrophages. We further show in subsequent experiments that, after the humanized mice were infected with aerosolized H37Rv, then treated with DS6A intravenously, the DS6A treated mice showed increased body weight and improved pulmonary function relative to control mice...
March 9, 2024: Communications Biology
https://read.qxmd.com/read/38417723/co-spray-dried-inhalable-composite-powders-of-ciprofloxacin-and-alginate-oligosaccharide-as-anti-biofilm-therapy
#3
JOURNAL ARTICLE
Li Zhang, Hriday Bera, Yi Guo, Changzhi Shi, Johan Ulrik Lind, Carmen Radeke, Junwei Wang, Hengzhuang Wang, Xia Zhao, Dongmei Cun, Mingshi Yang
The treatment of chronic respiratory infections caused by biofilm formation are extremely challenging owing to poor drug penetration into the complex biofilm structure and high drug resistance. Local delivery of an antibiotic together with a non-antibiotic adjuvant to the lungs could often enhance the therapeutic responses by targeting different bacterial growth pathways and minimizing drug resistance. In this study, we designed new inhalable dry powders containing ciprofloxacin (CIP) and OligoG (Oli, a low-molecular-weight alginate oligosaccharide impairing the mucoid biofilms by interacting with their cationic ions) to combat respiratory bacterial biofilm infections...
February 26, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38366100/liposomal-formulation-reduces-transport-and-cell-uptake-of-colistin-in-human-lung-epithelial-calu-3-cell-and-3d-human-lung-primary-tissue-models
#4
JOURNAL ARTICLE
Yijing Huang, Shihui Yu, Maizbha Uddin Ahmed, Qi Tony Zhou
Respiratory tract infections caused by multi-drug-resistant (MDR) bacteria have been a severe risk to human health. Colistin is often used to treat the MDR Gram-negative bacterial infections as a last-line therapy. Inhaled colistin can achieve a high concentration in the lung but none of aerosolized colistin products has been approved in the USA. Liposome has been reported as an advantageous formulation strategy for antibiotics due to its controlled release profile and biocompatibility. We have developed colistin liposomal formulations in our previous study...
February 17, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38365028/airborne-antibiotic-and-metal-resistance-genes-a-neglected-potential-risk-at-e-waste-recycling-facilities
#5
JOURNAL ARTICLE
V Agarwal, B Meier, C Schreiner, R Figi, Y Tao, J Wang
Heavy metal-rich environments can promote the selection of metal-resistance genes (MRGs) in bacteria, often leading to the simultaneous selection of antibiotic-resistance genes (ARGs) through a process known as co-selection. To comprehensively evaluate the biological pollutants at electronic-waste (e-waste) recycling facilities, air, soil, and river samples were collected at four distinct Swiss e-waste recycling facilities and analyzed for ARGs, MRGs, mobile genetic elements (MGEs), endotoxins, and bacterial species, with correlations drawn to heavy metal occurrence...
February 14, 2024: Science of the Total Environment
https://read.qxmd.com/read/38351924/a-case-of-hot-tub-lung-secondary-to-mycobacterium-avium-complex-in-victoria-australia
#6
Louis Chhor, Reditta Soraya Tumali, Caroline Östberg, Anish Sachdev
Hot tub lung (HTL) is a type of Hypersensitivity Pneumonitis (HP) caused by inhalation of aerosols containing non-tuberculous mycobacteria (NTM). We report the first case of hot tub lung in Victoria, Australia. A 31-year-old female presented with 3 weeks of dyspnoea, fevers and malaise, despite a course of antibiotics. She had used an indoor spa frequently for the past several months. She was hypoxic saturating 86% on room air. Examination revealed fine bilateral basal crepitations without wheeze. Inflammatory markers were elevated...
February 2024: Respirology Case Reports
https://read.qxmd.com/read/38338937/immunopathology-of-pulmonary-mycobacterium-tuberculosis-infection-in-a-humanized-mouse-model
#7
JOURNAL ARTICLE
Afsal Kolloli, Ranjeet Kumar, Vishwanath Venketaraman, Selvakumar Subbian
Despite the availability of antibiotic therapy, tuberculosis (TB) is prevailing as a leading killer among human infectious diseases, which highlights the need for better intervention strategies to control TB. Several animal model systems, including mice, guinea pigs, rabbits, and non-human primates have been developed and explored to understand TB pathogenesis. Although each of these models contributes to our current understanding of host- Mycobacterium tuberculosis (Mtb) interactions, none of these models fully recapitulate the pathological spectrum of clinical TB seen in human patients...
January 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38302495/escherichia-coli-resistance-mechanism-acrab-tolc-efflux-pump-interactions-with-commonly-used-antibiotics-a-molecular-dynamics-study
#8
JOURNAL ARTICLE
Brooke L Smith, Sandun Fernando, Maria D King
While antibiotic resistance poses a threat from both Gram-positive bacteria (GPB) and Gram-negative bacteria (GNB), GNB pose a more imminent public health hazard globally. GNB are a threat to growing antibiotic resistance because of the complex makeup of the membrane. The AcrAB-TolC efflux pump is a known resistance mechanism of Escherichia coli (E. coli) cells. This study utilized molecular dynamics modeling to visualize some of the changes occurring at a molecular level when airborne bacteria are exposed to stress and antibiotics...
February 1, 2024: Scientific Reports
https://read.qxmd.com/read/38294113/tularemia-from-veterinary-occupational-exposure
#9
JOURNAL ARTICLE
Grace E Marx, Emily Curren, Marisa Olesen, Laura Cronquist, Levi Schlosser, Matthew Nichols, Maria Bye, Andrea Cote, David W McCormick, Christina A Nelson
Tularemia is a disease caused by Francisella tularensis, a highly infectious bacteria that can be transmitted to humans by direct contact with infected animals. Because of the potential for zoonotic transmission of F. tularensis, veterinary occupational risk is a concern. Here, we report on a human case of tularemia in a veterinarian after an accidental needlestick injury during abscess drainage in a sick dog. The veterinarian developed ulceroglandular tularemia requiring hospitalization but fully recovered after abscess drainage and a course of effective antibiotics...
January 31, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38294111/efficacy-of-doxycycline-and-ciprofloxacin-for-treatment-of-pneumonic-tularemia-in-cynomolgus-macaques
#10
JOURNAL ARTICLE
Mark S Williams
BACKGROUND: The incidence of pneumonic tularemia is very low; therefore, it is not feasible to conduct clinical efficacy testing of tularemia medical countermeasures (MCMs) in humans. The US Food and Drug Administration's Animal Model Qualification Program under the Drug Development Tools Program is a regulatory pathway for animal models used in MCM efficacy testing and approval under the Animal Rule. The National Institute of Allergy and Infectious Diseases and Biomedical Advanced Research and Development Authority worked together to qualify the cynomolgus macaque model of pneumonic tularemia...
January 31, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38293171/a-bacteriophage-cocktail-targeting-yersinia-pestis-provides-strong-post-exposure-protection-in-a-rat-pneumonic-plague-model
#11
Paul B Kilgore, Jian Sha, Emily K Hendrix, Blake H Neil, William S Lawrence, Jennifer E Peel, Lauren Hittle, Joelle Woolston, Alexander Sulakvelidze, Jennifer A Schwartz, Ashok K Chopra
Yersinia pestis , one of the deadliest bacterial pathogens ever known, is responsible for three plague pandemics and several epidemics, with over 200 million deaths during recorded history. Due to high genomic plasticity, Y. pestis is amenable to genetic mutations as well as genetic engineering that can lead to the emergence or intentional development of pan-drug resistant strains. The dissemination of such Y. pestis strains could be catastrophic, with public health consequences far more daunting than those caused by the recent COVID-19 pandemic...
January 18, 2024: bioRxiv
https://read.qxmd.com/read/38231385/storage-stability-of-lysostaphin-solution-and-its-pulmonary-delivery
#12
JOURNAL ARTICLE
Ping Zeng, Pengfei Zhang, Ho Wan Chan, Shing Fung Chow, Jenny Ka Wing Lam, Margaret Ip, Sharon Shui Yee Leung
Methicillin-resistant Staphylococcus aureus (MRSA) has become a leading causative pathogen of nosocomial pneumonia with an alarming in-hospital mortality rate of 30%. Last resort antibiotic, vancomycin, has been increasingly used to treat MRSA infections, but the rapid emergence of vancomycin-resistant strains urges the development of alternative treatment strategies against MRSA-associated pneumonia. The bacteriolytic enzyme, lysostaphin, targeting the cell wall peptidoglycan of S. aureus, has been considered as a promising alternative for MRSA infections...
January 17, 2024: Drug Delivery and Translational Research
https://read.qxmd.com/read/38222214/same-pathogen-different-manifestations-a-case-of-extrapulmonary-tuberculosis
#13
Joana A Cabrera, Margarida Mota
Tuberculosis (TB) remains the most prevalent contagious disease worldwide and a significant cause of morbidity, ranking as the second most deadly disease globally. The transmission of the disease occurs through aerosols via the respiratory route, predominantly affecting pulmonary tissue. However, the pathogen can disseminate and infect any organ within the body. Up to 15% of patients exhibit extrapulmonary involvement. The case involves a 59-year-old male who presented to the emergency department complaining of abdominal pain and subfebrile episodes, without any other significant symptoms or findings on physical examination...
December 2023: Curēus
https://read.qxmd.com/read/38197850/aerosolizable-pyrazinamide-loaded-biodegradable-nanoparticles-for-the-management-of-pulmonary-tuberculosis
#14
JOURNAL ARTICLE
Komal Parmar, Swati Sondarva
Background: Pyrazinamide is a Biopharmaceutical Classification System class III antibiotic indicated for active tuberculosis. Methods: In the present work, pyrazinamide-loaded biodegradable polymeric nanoparticles (PNPs) based dry powder inhaler were developed using the double emulsion solvent evaporation technique and optimized using design of experiments to provide direct pulmonary administration with minimal side effects. Batches were characterized for various physicochemical and aerosol performance properties...
January 10, 2024: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://read.qxmd.com/read/38195407/recognize-aerosol-transmissible-disease-and-require-appropriate-protections-promote-worker-driven-biomonitoring-and-worker-driven-remedy-restrict-antibiotics-in-animal-agriculture-legalize-marijuana-federally-and-require-pot-purveyors-to-sign-neutrality-agreements
#15
EDITORIAL
https://read.qxmd.com/read/38176521/establishment-of-portable-pseudomonas-aeruginosa-detection-platform-based-on-one-tube-crispr-cas12a-combined-with-recombinase-polymerase-amplification-technology
#16
JOURNAL ARTICLE
Haitao Yang, Aibo Liu, Fenfen Ma, Xuzhu Gao, Kun Wang, Yan Wang
Pseudomonas aeruginosa, a common Gram-negative bacterium, is associated with diverse diseases. Its increasing resistance to antibiotics presents challenges in clinical treatment. The predominant diagnostic approach involves conventional biochemical cultures, known for their time and labor intensiveness. Despite progress in isothermal amplification studies, limitations persist, including reliance on specialized equipment, intricate primer design, and aerosol contamination. Therefore, there is a demand for enhanced clinical assays...
January 2, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38157791/studies-on-the-airborne-bacterial-communities-and-antimicrobial-resistance-genes-in-duck-houses-based-on-metagenome-and-pcr-analysis
#17
JOURNAL ARTICLE
Lei Qu, Tongjie Chai, Zhiyun Guo, Zhaopeng Zhang, Ziqiu Huang, Ning Li
The threat of antimicrobial resistance (AMR) is on the rise globally, especially with the development of animal husbandry and the increased demand for antibiotics. Livestock and poultry farms, as key sites for prevalence of antibiotic-resistant bacteria (ARB), can spread antimicrobial resistance genes (ARGs) through microbial aerosols and affect public health. In this study, total suspended particulate matter (TSP) and airborne culturable microorganisms were collected from duck houses in Tai'an, Shandong Province, and the bacterial communities and airborne ARGs were analyzed using metagenomics and PCR methods...
December 9, 2023: Poultry Science
https://read.qxmd.com/read/38153060/antibiotic-sensitivity-of-environmental-legionella-pneumophila-strains-isolated-in-poland
#18
JOURNAL ARTICLE
Iwona Gładysz, Agnieszka Sikora, Małgorzata Wójtowicz-Bobin, Adam Szepeluk, Renata Matuszewska, Marta Bartosik, Jan Kazimierz Karczewski
INTRODUCTION AND OBJECTIVE: Legionella bacteria are commonly found in natural aquatic environments such as rivers, lakes, ponds and hot springs. Legionella infection occurs through the inhalation of water-air aerosol generated, for example, by showers or hot tubs. The most common species responsible for infection is Legionella pneumophila, which can cause Pontiac fever, and Legionnaires' disease, as well as a rare extrapulmonary form. The aim of the study's is to assess the susceptibility of Legionella pneumophila bacteria isolated from water systems of public buildings in Poland to antibiotics and chemotherapeutic agents used in the treatment of Legionellosis pneumonia...
December 22, 2023: Annals of Agricultural and Environmental Medicine: AAEM
https://read.qxmd.com/read/38145686/temporal-variations-of-antimicrobial-resistance-genes-in-aerosols-a-one-year-monitoring-at-the-puy-de-d%C3%A3-me-summit-central-france
#19
JOURNAL ARTICLE
Florent Rossi, Caroline Duchaine, Romie Tignat-Perrier, Muriel Joly, Catherine Larose, Aurélien Dommergue, Nathalie Turgeon, Marc Veillette, Karine Sellegri, Jean-Luc Baray, Pierre Amato
The recent characterization of antibiotic resistance genes (ARGs) in clouds evidenced that the atmosphere actively partakes in the global spreading of antibiotic resistance worldwide. Indeed, the outdoor atmosphere continuously receives large quantities of particles of biological origins, emitted from both anthropogenic or natural sources at the near Earth's surface. Nonetheless, our understanding of the composition of the atmospheric resistome, especially at mid-altitude (i.e. above 1000 m a...
December 23, 2023: Science of the Total Environment
https://read.qxmd.com/read/38143689/the-efficacy-and-safety-of-intravenous-colistin-plus-aerosolized-colistin-versus-intravenous-colistin-alone-in-critically-ill-trauma-patients-with-multi-drug-resistant-gram-negative-bacilli-infection
#20
JOURNAL ARTICLE
Loveleen Maan, Neelesh Anand, Ghanshyam Yadav, Manjaree Mishra, Munesh K Gupta
BACKGROUND AND AIM: Gram-negative bacteria (GNB) with potential multiple drug resistance (MDR) have emerged as a major group of organisms causing ventilator-associated pneumonia (VAP). Higher concentrations are deposited directly in the lungs when antibiotics are given via inhalation, minimizing systemic side effects. This study aims to compare the efficacy and safety of intravenous plus aerosolized colistin versus intravenous (IV) colistin alone in critically ill trauma patients who reported MDR-GNB infection on endotracheal aspirate culture...
November 2023: Curēus
keyword
keyword
47826
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.