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Janani S Reisenauer, Wadad Mneimneh, Sarah Jenkins, Aaron S Mansfield, Marie Christine Aubry, Karen J Fritchie, Mark S Allen, Shanda H Blackmon, Stephen D Cassivi, Francis C Nichols, Dennis A Wigle, K Robert Shen, Jennifer M Boland
INTRODUCTION: Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms. Most follow a benign course, but a subset will recur or metastasize. Various risk stratification schemes have been proposed for SFT, but none have been universally endorsed and few have focused on pleuropulmonary SFT. METHODS: Histologic sections were examined from surgically resected pleuropulmonary SFT, with confirmatory immunohistochemistry. Patients were risk stratified using 4 prediction models as proposed by de Perrot, Demicco (original and modified), and Tapias...
June 20, 2018: Journal of Thoracic Oncology
Shijing Wu, Lantian Gao, Changshui Chen, Jun Li, Sailing He
Functional near-infrared spectroscopy (fNIRS) was used to investigate the stability of resting state functional connectivity (RSFC) in the prefrontal cortex. In a longitudinal study for investigating the stability of RSFC with time, we recruited 6 healthy adult subjects to undergo a 10-min resting state fNIRS scan once per day for 7 consecutive days. In a cross-sectional study, 62 healthy subjects underwent a single 10-min RSFC measurement. Three regions-of-interest (ROIs) were studied, the superior frontal gyrus (SFG), the middle frontal gyrus (MFG), and the inferior frontal gyrus (IFG)...
June 20, 2018: Neuroscience Letters
Kareem Jamani, Lynn E Onstad, Merav Bar, Paul A Carpenter, Elizabeth F Krakow, Rachel B Salit, Mary E D Flowers, Stephanie J Lee
Caregivers are critical to recipient recovery after hematopoietic cell transplant (HCT), however, little is known about their long-term health and quality of life (QoL). In this study, we surveyed 4446 caregiver/recipient pairs in the post-HCT period to describe their QoL and its determinants. In total, 849 caregiver/recipient pairs at a median of 6 years post autologous or allogeneic HCT responded. Among 849 responding caregivers at a median of 6 years post-HCT, 67% of caregivers were female and 68% indicated that they were still providing care to the recipient...
June 20, 2018: Biology of Blood and Marrow Transplantation
Linda Petronella Martina Maria Wijlaars, Pia Hardelid, Astrid Guttmann, Ruth Gilbert
OBJECTIVE: To determine whether changes in emergency admission rates during transition from paediatric to adult hospital services differed in children and young people (CYP) with and without underlying long-term conditions (LTCs). DESIGN: Cross-sectional study. SETTING: Emergency admissions between 2009 and 2011 recorded in the Hospital Episode Statistics Admitted Patient Care data in England. PARTICIPANTS: 763 199 CYP aged 10-24 years with and without underlying LTCs (LTCs were defined using the International Classification of Diseases, 10th Revision codes recorded in the past 5 years)...
June 22, 2018: BMJ Open
Anders Johnsson, Otilia Leon, Adalsteinn Gunnlaugsson, Per Nilsson, Peter Höglund
BACKGROUND AND PURPOSE: Anal squamous cell carcinoma is primarily treated with radiotherapy (RT), but the optimal RT dose for anal tumours of different sizes is not known. The purpose of this study was to identify determinants for local tumour control probability (LTCP). MATERIAL AND METHODS: From a large Nordic database 901 patients who received RT for anal cancer between 2000 and 2007 were selected. LTCP was analysed in a series of uni- and multivariable regression analyses...
June 19, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Shearwood McClelland, Timur Mitin, Reshma Jagsi, Charles R Thomas, Jerry J Jaboin
PURPOSE: The Hirsch index (h-index) has been shown to correlate with radiation oncology residents' having a first job in academics versus private practice, but it is limited by its inability to distinguish between the differing significance of coauthor roles in articles. METHODS: A list of 2016 radiation oncology resident graduates and their postresidency career choices was compiled. The Scopus bibliometric citation database was then searched to collect h-index data for articles limited to first author only (hf ) and first or second-author only (hs ) for each resident...
June 20, 2018: Journal of the American College of Radiology: JACR
Julia E Goldberg, Linda Moy, Andrew B Rosenkrantz
PURPOSE: To evaluate transgender patient care, gender inclusivity, and transgender health-related policies at breast imaging facilities across the United States. METHODS: A survey on breast imaging facilities' policies and practices regarding transgender care was distributed to the membership of the Society of Breast Imaging, consisting of approximately 2,500 breast radiologists across the United States. The survey was conducted by e-mail in January 2018. RESULTS: There were 144 survey respondents...
June 20, 2018: Journal of the American College of Radiology: JACR
Ananya Chakraborty, Madhurima Chatterjee, Harry Twaalfhoven, Marta Del Campo Milan, Charlotte E Teunissen, Philip Scheltens, Ruud D Fontijn, Wiesje M van Der Flier, Helga E de Vries
BACKGROUND: Increasing evidence suggests that cerebral vascular dysfunction is associated with the early stages of Alzheimer's disease (AD). Vascular endothelial growth factor (VEGF) is one of the key players involved in the development and maintenance of the vasculature. Here, we hypothesized that VEGF levels in cerebrospinal fluid (CSF) may be altered in AD patients with vascular involvement, characterized by the presence of microbleeds (MB), and in vascular dementia (VaD) patients compared to controls...
June 23, 2018: Alzheimer's Research & Therapy
Hope Gerlach, Evan Totty, Anu Subramanian, Patricia Zebrowski
Purpose: The purpose of this study was to quantify relationships between stuttering and labor market outcomes, determine if outcomes differ by gender, and explain the earnings difference between people who stutter and people who do not stutter. Method: Survey and interview data were obtained from the National Longitudinal Study of Adolescent to Adult Health. Of the 13,564 respondents who completed 4 waves of surveys over 14 years and answered questions about stuttering, 261 people indicated that they stutter...
June 22, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
Maiara Carmosina Hirt, Marta Cocco da Costa, Jaqueline Arboit, Marinês Tambara Leite, Lilian Zielke Hesler, Ethel Bastos da Silva
OBJECTIVE: Understand the social representations of violence against rural women, from the perspective of the elderly, considering how the generation and gender influence this aggravation. METHODS: Qualitative study, based on the Theory of Social Representations.It was carried out with 12 elderly rural women from a city of Rio Grande do Sul, in July and August of 2013. The data obtained through a projective technique and semi-structured interviews has been analyzed through the reference of the Social Representations and content analysis...
June 7, 2018: Revista Gaúcha de Enfermagem
Meng Ding, Yumeng Zhang, Xude Wang, Yuqing Zhao
Our previous study suggests a well-defined pharmacological activity of 20(R)-25-methoxyl-dammarane-3β,12β,20-triol (AD-1) and its metabolite 20(R)-dammarane-3β,12β,20,25-tetrol (AD-2). The current study aims to investigate the gender-related differences in pharmacokinetics, tissue distribution, and excretion of AD-1 and its metabolite in both male and female rats. A sensitive and rapid ultra-performance liquid chromatography tandem mass spectrometric (UPLC-MS/MS) method was developed for the simultaneous determination of AD-1 and AD-2 levels in plasma, various tissues, bile, urine, and feces...
June 7, 2018: Journal of Pharmaceutical and Biomedical Analysis
Julien Clément, Panagiota Toliopoulos, Nicola Hagemeister, François Desmeules, Alexandre Fuentes, Pascal-André Vendittoli
BACKGROUND: Normal 3D knee kinematics during gait is still not well understood, especially regarding differences between women and men. RESEARCH QUESTION: The objective of the present study was to characterize 3D knee kinematics during gait in healthy women and men with a validated tool. METHODS: Knee kinematics was analysed with the KneeKG™ system in 90 healthy subjects (49 females and 41 males). 3D knee rotations were compared between women and men, and between right and left knees...
June 11, 2018: Gait & Posture
Lisa M Boucher, Ahmed M Bayoumi, Amy E Mark, Curtis Cooper, Alana Martin, Zack Marshall, Rob Boyd, Pam Oickle, Nicola Diliso, Dave Pineau, Brad Renaud, Sean LeBlanc, Mark Tyndall, Olivia M Lee, Claire E Kendall
BACKGROUND: Chronic hepatitis C virus (HCV) infection is common among people who inject drugs (PWID) and is associated with morbidity and premature death. Although HCV can be cured, treatment may be inaccessible. We studied HCV testing, status and treatment among marginalized people who use drugs in Ottawa, Canada, a setting with universal insurance coverage for physician services. METHODS: We analyzed data from the Participatory Research in Ottawa: Understanding Drugs study, a cross-sectional, peer-administered survey of people who use drugs from 2012 to 2013...
June 22, 2018: Substance Use & Misuse
Wanke Feng, Dongbo Liu, Yiya Wang, Xin Shi, Fang Liu, Luning Sun, Li Ding
OBJECTIVES: The manuscript was mainly aimed to evaluate effects of food and gender on the pharmacokinetics of ticagrelor and its main active metabolite AR-C124910XX in healthy Chinese subjects observed in the bioequivalence studies of the two formulations of ticagrelor tablets. MATERIALS AND METHODS: The single-dose, two-sequence, two-period and crossover studies were respectively conducted under fasting and fed conditions. Plasma samples were analyzed by an HPLC-MS/MS method...
June 22, 2018: International Journal of Clinical Pharmacology and Therapeutics
Pietro Ferrara, Maria Elisa Amodeo, Annamaria Sbordone, Francesca Ianniello, Alberto Verrotti, Tommaso Petitti, Antonio Ruggiero
OBJECTIVE: The aim of this study is to determine the impact of a motivational therapy (MT) on the outcomes for individuals diagnosed with nocturnal enuresis (NE). MATERIAL AND METHODS: We enrolled 158 patients with NE referred to the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome, from January 2013 to September 2017. Of these, 21 were excluded because they didn't meet the inclusion criteria. The study was carried out in compliance with the Helsinki Declaration...
July 2018: Turkish Journal of Urology
Effat Khodadadi, Mehrnaz Mohammadpour, Saeed Reza Motamedian, Farnaz Kouhestani
Aim: To assess the failure rates of various pediatric dental treatments performed under general anesthesia (GA) after six months to five years of follow-up. Design: This multicenter retrospective cohort study was performed on patients treated by five pedodontists in two private hospitals located in northern Iran during 2010⁻2013 and comprised 155 patients. The patients were recalled and clinically examined. During the clinical examination of the primary teeth, oral hygiene, dmft index, and failure of previous treatments was evaluated...
June 22, 2018: Dentistry journal
Ferhat Arslan, Bahadir Ceylan, Ahmet Riza Sahin, Özgür Günal, Bircan Kayaaslan, Kenan Uğurlu, Alpaslan Tanoğlu, Gülsen Iskender, Selma Tosun, Aynur Atilla, Fatma Sargin, Ayse Batirel, Ergenekon Karagöz, Abdullah Sonsuz, Ali Mert
In this study, we aimed to determine the late relapse rate in hepatitis C patients with sustained virological response after interferon-based regimens, and evaluated the predictors of late relapse while comparing the real-life data of our country with that of others. A multicenter retrospective study was performed to investigate the data of patients infected with HCV who obtained sustained virological response after classical or pegylated interferon alpha (PegIFNα) and ribavirin (RBV) for 48 weeks. Sustained virological response was based on negative HCV RNA level by PCR at the end of six months after the therapy...
June 1, 2018: Le Infezioni in Medicina
Katharine A Rimes, Sandhya Shivakumar, Greg Ussher, Dan Baker, Qazi Rahman, Elizabeth West
BACKGROUND: Lesbian, gay, and bisexual (LGB) youth have elevated suicidality rates. AIMS: To investigate LGB-related and other factors associated with suicide attempts, suicidal ideation, and future suicide risk in a large UK sample. METHOD: Logistic regression was used to investigate factors associated with suicidality in 3,275 LGB young adults from the Youth Chances project. RESULTS: Suicide attempts (lifetime) were reported by 13...
June 21, 2018: Crisis
C I Bassorgun, E C Sayar, M Baykara, O Kankavi
Surfactant protein-A (SP-A) belongs to a family of collagen-containing C-type lectins called collectins. SP-A is expressed by renal tubule epithelial cells. We investigated the distribution of SP-A in renal cell carcinomas (RCC) using immunohistochemical techniques and western blotting. We used 35 formalin fixed, paraffin embedded (FFPE) RCC tissue samples. We compared results with clinico-pathological parameters of RCC including age, sex, Fuhrman grade, tumor volume, tumor node metastasis (TNM) and clinical stage...
June 22, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Irja Ventä, Miira M Vehkalahti, Anna L Suominen
OBJECTIVES: The aim of the study was to characterize third molars that have remained disease-free in a representative sample of the Finnish population aged 30 years and older. MATERIALS AND METHODS: Two-staged stratified cluster sampling (N = 8028) was used, and 6005 subjects participated in a clinical oral examination and panoramic radiography. Disease-free third molars were characterized as follows: no dentinal caries, no filling, periodontal pocket depths of neighboring second molars less than 4 mm, and no radiographic pathological findings...
June 21, 2018: Clinical Oral Investigations
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