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https://www.readbyqxmd.com/read/29684916/predictors-of-rapid-cognitive-decline-in-patients-with-mild-to-moderate-alzheimer-disease-a-prospective-cohort-study-with-12-month-follow-up-performed-in-memory-clinics
#1
Achille E Tchalla, Jean-Pierre Clément, Isabelle Saulnier, Betty Beaumatin, Florent Lachal, Caroline Gayot, Anaïs Bosetti, Iléana Desormais, Anaïck Perrochon, Pierre-Marie Preux, Philippe Couratier, Thierry Dantoine
BACKGROUND/AIMS: Alzheimer disease (AD) is particularly devastating, with no cure, no means of prevention, and no proven way to slow progression. AD is associated with the worsening of cognitive function attributable to a variety of factors of which little is known. Our main objective was to determine factors associated with rapid cognitive decline (RCD) in older AD patients. METHODS: We conducted a 12-month, prospective, multi-centre cohort study. Community-living individuals aged ≥65 years with mild-to-moderate AD were included...
April 23, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29684845/medico-legal-aspects-of-disabilities-due-to-orthopedic-injuries-and-compensations-in-egypt
#2
Sherien Salah Ghaleb, Dalia Abd Elwahab Hassan, Alla Mohamed Shehab, Soad Abd El-Ghafar Mohamed Hassan
Disability is a complex problem that results in detrimental effects on the victim. The number of disabled has increased considerably. The development constitutes a good reason for paying more specific attention to society's growing number of disabled. The physician's duties are not only to describe the anatomic and physiological defects present in the injured individual, but also to answer questions regarding the patient ability to perform specific economic or social function. This study aimed to clear up some of the problems or difficulties that may face the medico-legal physician or any personal that may be concerned with the process of evaluation...
April 14, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29684536/gender-related-functional-connectivity-and-craving-during-gaming-and-immediate-abstinence-during-a-mandatory-break-implications-for-development-and-progression-of-internet-gaming-disorder
#3
Guangheng Dong, Ziliang Wang, Yifan Wang, Xiaoxia Du, Marc N Potenza
BACKGROUND: Although males more frequently develop Internet gaming disorder (IGD) as compared with females, few studies have examined gender-related neurocognitive differences in IGD. TASK AND DESIGN: fMRI and subjective data were collected from 119 subjects (IGD, male 29, female 25; recreational game use (RGU), male 34, female 31) when they were actively playing games and during a forced mandatory break. Analyses investigating effects of group (IGD, RGU) and gender (male, female) on the functional connectivity (FC) of executive control and reward systems linked to the dorsolateral prefrontal cortex (DLPFC) and striatum, respectively, were performed...
April 20, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29684300/adolescent-body-image-results-of-czech-elspac-study
#4
Sylva Šmídová, Jan Švancara, Lenka Andrýsková, Jan Šimůnek
OBJECTIVES: The study examined appearance and body satisfaction in adolescents. For these purposes, data from the European Longitudinal Study of Pregnancy and Childhood in the Czech Republic were used. METHODS: The data were collected in 2010 and the sample comprised 3,105 18-year-old respondents. RESULTS: The research found that the respondents who wished to reduce their weight were mostly women with BMI in the normal range. Based on the body cathexis scale, we found that women compared to men are more critical of stomach, hips, buttocks, and thighs, as well as overall weight and figure...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684299/age-and-gender-differences-in-health-risk-perception
#5
YoungHo Kim, InKyoung Park, SooJin Kang
OBJECTIVE: The current study investigated how adolescents perceive their own health risks and compare their own likelihood of health risks with that of others of the same age. Moreover, the study identified the differences in health risk perceptions between males and females. METHODS: A total of 625 adolescents (314 males and 311 females) from the Nowon district, geographically located in northern Seoul, voluntarily participated. In order to measure health risk perceptions a Korean version of self-other risk judgments profile was used...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29683375/-developmental-trauma-disorder-dtd-in-children-and-adolescents-results-from-a-patient-population-at-the-special-consultation-hour-for-traumatized-children-and-adolescents
#6
Franka Metzner, Kristina Dahm, Hertha Richter-Appelt, Silke Pawils, Miriam Juliane Moulaa-Edmondson, Kerstin Stellermann-Strehlow
Objective: Children and adolescents who have experienced interpersonal Type-II-trauma often develop symptoms going far beyond the Post-Traumatic Stress Disorder (PTSD). Van der Kolk (2009) suggested the Developmental Trauma Disorder (DTD) to define the extensive symptomatology; however, research on DTD is limited. Method: Frequency and group differences of DTD were examined based on physicians’ letters of n = 161 patients between one and 18 years (61 % female) from an out-patient unit for traumatized patients at a paediatric and adolescent psychiatry...
April 23, 2018: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/29683360/hydrogen-rich-water-improves-cognitive-impairment-gender-dependently-in-app-ps1-mice-without-affecting-a%C3%AE-clearance
#7
Chen Hou, Yunhua Peng, Chuan Qin, Fan Fan, Jiankang Liu, Jiangang Long
Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ injection-induced cognitive dysfunction. However, whether and how hydrogen affects AD pathogenesis remains uninvestigated...
April 23, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29683101/in-vivo-evaluation-of-free-and-chelated-accelerator-produced-actinium-225-radiation-dosimetry-and-toxicity-results
#8
Zewei Jiang, Ekaterina Revskaya, Darrell R Fisher, Ekaterina Dadachova
OBJECTIVE: The demand for the alpha-emitting radionuclide Actinium-225 (225Ac) for use in radionuclide therapy is growing. Producing 225Ac using high energy linear accelerators, cyclotrons or photoinduction could increase its supply. One potential problem with accelerator produced 225Ac using Thorium-232 targets is the presence in final product of 0.1-0.3% by activity of the long-lived 227Ac impurity at the end of irradiation. It is important to comprehensively evaluate the behavior of accelerator-produced 225Ac in vivo before using it in pre-clinical and clinical applications...
April 23, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29683100/pioglitazone-therapy-and-fractures-systematic-review-and-meta-analysis
#9
Velichka Pavlova, Elena Filipova, Katya Uzunova, Krassimir Kalinov, Toni Vekov
INTRODUCTION: Thiazolidinediones are group of synthetic medications used in type 2 diabetes treatment. Among available thiazolidinediones pioglitazone is gaining increased attention due to its lower cardiovascular risk in type 2 diabetes mellitus sufferers and seems a promising future therapy. Accumulating evidence suggests that diabetic patients may exert bone fractures due to such treatments. Simultaneously, female population is thought to be at greater risk. Still the safety outcomes of pioglitazone treatment especially in terms of fractures are questionable and need to be clarified...
April 23, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29683080/childhood-gender-nonconformity-and-intimate-partner-violence-in-adolescence-and-young-adulthood
#10
Avanti Adhia, Allegra R Gordon, Andrea L Roberts, Garrett M Fitzmaurice, David Hemenway, S Bryn Austin
Childhood gender nonconformity has been associated with numerous adverse experiences, including peer bullying and homophobic violence. However, little is known about gender nonconformity in the context of intimate relationships, independent of sexual orientation. This study aimed to examine associations between childhood gender nonconformity and intimate partner violence (IPV) in adolescence and early adulthood. Using data from the 2007 wave of the U.S. Growing Up Today Study ( N = 7,641, mean age = 22.8 years), we estimated risk ratios (RRs) for the association of gender nonconformity up to age 11 years and lifetime IPV victimization and perpetration...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29683079/the-link-between-domestic-violence-and-abuse-and-animal-cruelty-in-the-intimate-relationships-of-people-of-diverse-genders-and-or-sexualities-a-binational-study
#11
Damien W Riggs, Nik Taylor, Heather Fraser, Catherine Donovan, Tania Signal
Over the past three decades, a growing body of research has focused on experiences of domestic violence and abuse (DVA) among people of diverse genders and/or sexualities. Missing, however, has been a focus on what is known as "the link" between DVA and animal cruelty with regard to people of diverse genders and/or sexualities. The present article reports on a study of 503 people living in either Australia or the United Kingdom, who reported on both their intimate human relationships and their relationships with animals, including relationships that were abusive...
April 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29683049/adolescents-help-seeking-behavior-and-intentions-following-adolescent-dating-violence-a-systematic-review
#12
Kerrie Bundock, Carmen Chan, Olivia Hewitt
The review aimed to systematically identify and summarize empirical work examining adolescent victims' help-seeking behaviors and intentions in relation to their own experience of adolescent dating violence (ADV) and to critically evaluate the literature. Three main objectives were addressed: identify factors associated with help seeking, identify help-seeking source (who adolescents disclose to), and explore the barriers and facilitators for help seeking. Results were separated into actual help seeking and help-seeking intentions...
January 1, 2018: Trauma, Violence & Abuse
https://www.readbyqxmd.com/read/29682981/incidence-of-and-risk-factors-for-venous-thromboembolism-after-foot-and-ankle-surgery
#13
Samuel R Huntley, Eildar Abyar, Eva J Lehtonen, Harshadkumar A Patel, Sameer Naranje, Ashish Shah
BACKGROUND: Venous thromboembolism (VTE) is a rare but potentially lethal complication after orthopaedic foot and ankle surgery. The true incidence of VTE after orthopaedic foot and ankle surgery stratified by specific procedure has yet to be examined. The purpose of this study is to report the incidence of and identify risk factors for VTE in a large sample of patients receiving orthopaedic foot and ankle surgery. METHODS: In this study, we retrospectively analyzed data from the National Surgical Quality Improvement Program 2006 to 2015 data files...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29682919/risk-factors-associated-with-frequent-alcohol-binge-drinking-among-jamaicans-does-gender-matter
#14
Wendel D Abel, Steve Weaver, Tana Ricketts Roomes, Chinwendu F Agu, Patrice Whitehorne Smith, Daniel C Oshi, Joy Harrison, Kristen Smith, Gabrielle Mitchell, Ashley Belinfante, Tania Rae, Sarah N Oshi
Objective: Alcohol is one of the most commonly consumed substances in Jamaica, despite the many health problems associated with excessive alcohol use. The aim of this study was to identify potential risk factors for alcohol binge drinking among Jamaicans, and determine if there were significant gender differences in the associations between identified risk factors and frequent binge drinking. Methods: Data collected from the 2016 National Household Survey Jamaica were analysed. Descriptive and inferential statistics were computed using SPSS...
April 23, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29682495/obesity-and-overweight-among-brazilian-early-adolescents-variability-across-region-socioeconomic-status-and-gender
#15
Chris Fradkin, Nadia C Valentini, Glauber C Nobre, João O L Dos Santos
Introduction: As with most emerging nations, Brazil lacks up-to-date data on the prevalence of obesity and overweight among its children. Of particular concern is the lack of data on children in early adolescence, considered by many to be the crucial stage for weight-related healthcare. Objective: To assess regional, socioeconomic, and gender differences in the prevalence of obesity and overweight among Brazilian early adolescents. Methods: A cross-sectional study was conducted on a racially diverse sample of students aged 10-13 years, from schools in three geographic regions (north, northeast, south) ( N  = 1,738)...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29682433/a-comparative-review-of-demographics-incidence-and-epidemiology-of-histologically-confirmed-intracranial-tumors-in-brazil-and-bulgaria
#16
REVIEW
George S Stoyanov, Jonathan S Sarraf, Boyko K Matev, Deyan L Dzhenkov, Martina Kitanova, Bogomil Iliev, Peter Ghenev, Anton B Tonchev, Yavor Enchev, Fernando Adami, Luis Eduardo W De Carvalho
Intracranial tumors (ICTs) attract numerous scientific teams and tremendous financial resources worldwide. These lesions of the central nervous system (CNS) can be both benign and malignant in biological behavior as well as local or metastatic in origin. We compared data from two studies on primary and metastatic ICTs from Brazil and Bulgaria, based on histopathologically confirmed ICTs from tertiary health centers. Primary ICTs significantly outweigh the frequency of metastatic ICTs. Primary ICTs represent 86...
February 19, 2018: Curēus
https://www.readbyqxmd.com/read/29682332/gender-and-outcomes-in-non-small-cell-lung-cancer-an-old-prognostic-variable-comes-back-for-targeted-therapy-and-immunotherapy
#17
Joseph A Pinto, Carlos S Vallejos, Luis E Raez, Luis A Mas, Rossana Ruiz, Junior S Torres-Roman, Zaida Morante, Jhajaira M Araujo, Henry L Gómez, Alfredo Aguilar, Denisse Bretel, Claudio J Flores, Christian Rolfo
Background: There are well-known differences in gender outcome in non-small cell lung cancer (NSCLC) and other cancers. In this work, we evaluated several randomised clinical trials to explore the gender influence in the outcome of patients with NSCLC treated with targeted therapy and immunotherapy. Methods: We performed a series of meta-analysis to compare the gender outcome in the routine setting for overall survival and progression-free survival (PFS) in phase III randomised clinical trials comparing EGFR inhibitors versus chemotherapy (OPTIMAL, LUX-lung 3, LUX-lung 6, EURTAC, ENSURE and WTJOG); ALK inhibitors versus chemotherapy (ASCEND 4, ASCEND 5, PROFILE 1014 and NCT009323893) and anti-PD1 checkpoint inhibitors versus chemotherapy (CheckMate 017, CheckMate 026, CheckMate 057, KEYNOTE 010 and KEYNOTE 024)...
2018: ESMO Open
https://www.readbyqxmd.com/read/29682236/the-participation-of-early-maladaptive-schemas-emss-in-the-perception-of-pain-in-patients-with-migraine-a-psychological-profile
#18
Ketlin Helenise Dos Santos Ribas, Valdenilson Ribeiro Ribas, Silano Souto Mendes Barros, Valéria Ribeiro Ribas, Maria da Glória Nogueira Filizola, Renata de Melo Guerra Ribas, Paulo César da Silva, Carlos Augusto Cardoso Kucera, Hugo André de Lima Martins
Young's early maladaptive schemas questionnaire (YSQ-S3) is used to understand psychological aspects. Objective: EMSs were evaluated in patients with migraine. Methods: Sixty-five subjects were evaluated using the YSQ-S3 under standard conditions in a room with air conditioning at 22 ± 2°C. The subjects were stratified by morbidity (migraine), gender (male/female) and age (18-29 / 30-39 / 40-55). Controls (without migraine), n = 27 and patients (with migraine), n = 38, men (n = 19) and women (n = 46); participants aged 18-29 years, n = 34, aged 30-39 years, n = 14 and aged 40-55 years, n = 17...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29682029/meningioma-consistency-correlation-between-magnetic-resonance-imaging-characteristics-operative-findings-and-histopathological-features
#19
Mahmoud Alyamany, Mohammad M Alshardan, Abdullah Abu Jamea, Nahid ElBakry, Lahbib Soualmi, Yasser Orz
Introduction: Intracranial meningiomas account for 30% of all primary intracranial tumors. Surgical resection remains the mainstay of the treatment for meningiomas. The magnetic resonance of intracranial meningiomas has been largely discussed in many reports of the radiological and neurosurgical literature. To date, a few studies have been attempted to differentiate the tumor characteristics of meningiomas based on magnetic resonance imaging (MRI) studies. Objective: The objective of the study is to evaluate the relationship between MRI signal characteristics of intracranial meningiomas and consistency of tumor using objective measures...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681941/clinical-anxiety-among-saudi-postgraduate-pediatric-dentistry-students-in-jeddah-city
#20
Manal Almalik, Abeer Alnowaiser, Omar El Meligy, Jamal Sallam, Yusra Balkheyour
Objective: To determine anxiety in relation to gender, Grade Point Average (GPA), level of education and academic and clinical situations in Jeddah, Saudi Arabia. Also, to identify academic and clinical anxiety levels among postgraduate pediatric dentistry students. Methods: A cross-sectional study at governmental training hospitals was conducted. All registered postgraduate students in pediatric dental programs during the year 2015-2016 were included in the study...
2018: International Journal of Dentistry
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