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Endocrinology ophthalmology

Fabiana Q Silva, Mehreen Adhi, Karen M Wai, Leann Olansky, M Cecilia Lansang, Rishi P Singh
BACKGROUND AND OBJECTIVE: The purpose of this study was to identify whether endocrinologists and primary care physicians (PCP) adequately screen for ophthalmic symptoms/signs within office visits and provide timely ophthalmology referrals in patients with diabetes. PATIENTS AND METHODS: Patients between the ages of 18 years and 80 years with diabetes who underwent an office visit with an endocrinologist or a PCP between January 1, 2014, and December 31, 2014, were identified...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Kornelija Ruskyte, Rasa Liutkevicienė, Alvita Vilkeviciute, Paulina Vaitkiene, Indre Valiulytė, Brigita Glebauskiene, Loresa Kriauciuniene, Dalia Zaliuniene
Pituitary adenoma (PA) is one of the most common abnormalities in the sellar region. Despite the fact that PA is a benign monoclonal neoplasm, it can cause serious complications, including ophthalmological, neurological and endocrinological abnormalities. Currently, the causes that increase the progression of tumors are unknown. Epigenetic silencing of the matrix metalloproteinase-14 (MMP-14) and transforming growth factor beta-1 (TGFβ-1) genes may be associated with the development of PA, since these genes are important in the processes of tumor metastasis and angiogenesis...
October 2016: Oncology Letters
Mateo Ziu, Ian F Dunn, Christopher Hess, Maria Fleseriu, Mary E Bodach, Luis M Tumialan, Nelson M Oyesiku, Kunal S Patel, Renzhi Wang, Bob S Carter, James Y Chen, Clark C Chen, Chirag G Patil, Zachary Litvack, Gabriel Zada, Manish K Aghi
BACKGROUND: Nonfunctioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. Due to the lack of hormonal hypersecretion, posttreatment follow-up evaluation of NFPAs is challenging. OBJECTIVE: To create evidence-based guidelines in an attempt to formulate guidance for posttreatment follow-up in a consistent, rigorous, and cost-effective way. METHODS: An extensive literature search was performed. Only clinical articles describing postoperative follow-up of adult patients with NFPAs were included...
October 2016: Neurosurgery
Qing Wang, Xiao-Jie Lu, Jun Sun, Jing Wang, Ci You Huang, Zhi Feng Wu
BACKGROUND: Ectopic thyrotropin (TSH)-secreting pituitary adenomas are rare and can often be misdiagnosed as primary hyperthyroidism. We present a case of an ectopic suprasellar TSH-secreting pituitary adenoma. A literature review of previously reported ectopic TSH-secreting and suprasellar pituitary adenomas is included to illustrate the clinical characteristics of this disease entity and the diversity of operative approaches to treating ectopic suprasellar pituitary adenomas. CASE DESCRIPTION: A 46-year-old man presented with typical clinical signs of hyperthyroidism and a history of progressive visual field impairment and vision loss...
August 24, 2016: World Neurosurgery
Leonardo Vieira, Cesar L Boguszewski, Luiz Antônio de Araújo, Marcello D Bronstein, Paulo Augusto C Miranda, Nina R de C Musolino, Luciana A Naves, Lucio Vilar, Antônio Ribeiro-Oliveira, Mônica R Gadelha
Clinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumors after prolactinomas. The absence of clinical symptoms of hormonal hypersecretion can contribute to the late diagnosis of the disease. Thus, the majority of patients seek medical attention for signs and symptoms resulting from mass effect, such as neuro-ophthalmologic symptoms and hypopituitarism. Other presentations include pituitary apoplexy or an incidental finding on imaging studies. Mass effect and hypopituitarism impose high morbidity and mortality...
August 2016: Archives of Endocrinology and Metabolism
Seungjoo Lee, Jun Ho Choi, Chang Jin Kim, Jeong Hoon Kim
OBJECT: Hypophysitis is a rare disease entity mimicking a pituitary adenoma. In spite of crucial disease involving a pituitary gland which is a main component of hormonal axis, there have been minimal researches regarding the hypophysitis. In this study, we described the constellation of the preoperative findings including clinical, radiologic, and endocrinologic features, as well as postoperative outcomes of the hypophysitis. METHODS: The authors reviewed the data retrospectively of a total of 2,814 patients who underwent microsurgery due to pituitary mass lesion (Asan Medical Center)...
July 28, 2016: World Neurosurgery
Rabih Hage, Sheila R Eshraghi, Nelson M Oyesiku, Adriana G Ioachimescu, Nancy J Newman, Valérie Biousse, Beau B Bruce
BACKGROUND: Pituitary apoplexy (PA) often presents with acute headache and neuro-ophthalmic manifestations, including ocular motility dysfunction (OMD) from cranial nerve palsies (CNPs). Our goal was to describe the epidemiology and outcomes of OMD in a large, single-center series of patients with PA. METHODS: We conducted a retrospective chart review of all patients with PA seen in our pituitary center between January 1995 and December 2012. Presenting neuro-ophthalmic, endocrine, and radiologic data, as well as neuro-ophthalmology follow-up data, were collected...
October 2016: World Neurosurgery
Ercan Bal, Kamil Öge, Mustafa Berker
OBJECTIVE: Craniopharyngioma resection is one of the most challenging surgical procedures. Herein, we have describe our extended endoscopic endonasal transsphenoidal surgery (EETS) technique, and the results of nine years of use in primary and recurrent/residual craniopharyngiomas. METHOD: This study reviewed 28 EETSs in 25 patients with craniopharyngiomas between January of 2006 and September of 2015. The patients were divided into two groups, newly diagnosed patients (group A, n=15), and patients having residual or recurrent tumors (group B, n=10)...
July 11, 2016: World Neurosurgery
Elon H C van Dijk, Greet Dijkman, Nienke R Biermasz, Femke M van Haalen, Alberto M Pereira, Camiel J F Boon
PURPOSE: To describe 4 patients who were diagnosed with chronic central serous chorioretinopathy (cCSC), which appeared to be the presenting symptom of Cushing syndrome (CS). METHODS: In this retrospective review of charts, all patients received extensive ophthalmologic examination and endocrinologic analyses. RESULTS: A 56-year-old man and a 49-year-old woman were treated because of bilaterally active, therapy-resistant cCSC. The clinical sign indicative for CS leading to referral to the endocrinologist was muscle weakness in the man and plethora in the woman...
August 4, 2016: European Journal of Ophthalmology
Jwu Jin Khong, Sue Finch, Chamika De Silva, Stacey Rylander, Jamie E Craig, Dinesh Selva, Peter R Ebeling
CONTEXT: Previous association studies suggest the development of Graves' orbitopathy (GO) is variably influenced by environmental risk factors. OBJECTIVE: To determine the risk factors and predict odds for developing GO in Graves' hyperthyroidism (GH). DESIGN: Case-control study. SETTING: Multi-centre Australian Thyroid-associated Orbitopathy Research group consisting of tertiary endocrinology and ophthalmology outpatients and related private practices...
July 2016: Journal of Clinical Endocrinology and Metabolism
Nurten Terkes, Hicran Bektas
AIM: To evaluate the psychometric properties of the Diabetes Symptoms Checklist-Revised (DSC-R), as measures of diabetes-related symptoms, in patients with type 2 diabetes in Turkey. METHODS: This research was carried out on 340 patients diagnosed with type 2 diabetes in the Department of Endocrinology and Metabolic Diseases of a university hospital in Turkey, between 25 January 2011 and 1 April 2011. Personal information forms developed by the researchers and the DSC-R were used as the data tools...
April 2016: Japan Journal of Nursing Science: JJNS
S De Sio, C Goglia, A Cristaudo, E Pacella, F Romanelli, V Santilli, A Vitarelli, D Mandolesi, F Balladore, H Nieto
BACKGROUND: The research presented in this paper analyses the clinic-pathological manifestations and work-related health risks identified among outpatients treated in the hospitals of Rome and Buenos Aires. MATERIALS AND METHODS: The occupational anamnestic data were collected between 2013 and 2014 through questionnaires with specific items aimed at detecting occupational diseases classified by target organ systems in outpatient clinics of cardiology, dermatology, physical medicine, ophthalmology, orthopedics, endocrinology (thyroid and gonads)...
January 2016: Annali di Igiene: Medicina Preventiva e di Comunità
Mohamed A El Beltagy, Mohamed Reda, Abdelrhman Enayet, Mohamed Saad Zaghloul, Madeha Awad, Wael Zekri, Hala Taha, Nada El-Khateeb
INTRODUCTION: Optic pathway gliomas (OPGs) are rare neoplasms in children with an unpredictable clinical course. There is significant controversy regarding the optimal management and outcome of these patients. METHODS: Charts of all patients with OPG diagnosed and treated at Children's Cancer Hospital Egypt between July 2007 and July 2014 were retrospectively reviewed. We evaluated the roles of surgical, ophthalmologic, endocrinologic, neurologic, and treatment aspects of care...
May 2016: World Neurosurgery
Nina Xie, Beisha Tang
In principle, induced pluripotent stem cells (iPSCs) are generated from somatic cells by reprogramming and gaining the capacity to self-renew indefinitely as well as the ability to differentiate into cells of different lineages. Human iPSCs have absolute advantages over human embryonic stem cells (ESCs) and animal models in disease modeling, drug screening, and cell replacement therapy. Since Takahashi and Yamanaka first described in 2007 that iPSCs can be generated from human adult somatic cells by retroviral transduction of the four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, disease specific iPSC lines have sprung up worldwide like bamboo shoots after a spring rain, making iPSC one of the hottest and fastest moving topics in modern science...
2016: Stem Cells International
Heather E Moss
BACKGROUND: As the prevalence of obesity increases, so, too, do the prevalences of weight-related diseases and surgical procedures to promote weight loss. It is important for neuro-ophthalmologists to be familiar with these procedures and possible downstream effects on afferent and efferent visual function. EVIDENCE ACQUISITION: Review of ophthalmology, neurology, general surgery, obesity, endocrinology, nutrition, psychiatry, and neurosurgery literature. RESULTS: Bariatric surgery is a safe and effective treatment for weight loss in obese individuals...
March 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Jens Conrad, Ali Ayyad, Christian Wüster, Wael Omran, Matthias M Weber, Moritz A Konerding, Wibke Müller-Forell, Alf Giese, Joachim Oertel
OBJECTIVE Over the past 2 decades, endoscopy has become an integral part of the surgical repertoire for skull base procedures. The present clinical evaluation and cadaver study compare binostril and mononostril endoscopic transnasal approaches and the surgical techniques involved. METHODS Forty patients with pituitary adenomas were treated with either binostril or mononostril endoscopic surgery. Neurosurgical, endocrinological, ophthalmological, and neuroradiological examinations were performed. Ten cadaver specimens were prepared, and surgical aspects of the preparation and neuroradiological examination were documented...
August 2016: Journal of Neurosurgery
Mathias Kunz, Silke B Nachbichler, Lorenz Ertl, Gunther Fesl, Rupert Egensperger, Maximilian Niyazi, Irene Schmid, Joerg Christian Tonn, Aurelia Peraud, Friedrich Wilhelm Kreth
To analyze efficacy, functional outcome, and treatment toxicity of low-dose rate I-125 brachytherapy (SBT) alone or in combination with best safe resection (in case of larger tumor volumes) as first-line treatment for pediatric low-grade gliomas (PLGGs) not suitable for complete resection. Consecutively treated (2000-2014) complex located circumscribed WHO grade I/II PLGGs were included. For small tumors (≤4 cm in diameter) SBT alone was performed; for larger tumors best safe resection and subsequent SBT was chosen...
March 2016: Cancer Medicine
Gema Ariceta, Juan Antonio Camacho, Matilde Fernández-Obispo, Aurora Fernández-Polo, Josep Gamez, Judit García-Villoria, Enrique Lara Monteczuma, Pere Leyes, Nieves Martín-Begué, Federico Oppenheimer, Manel Perelló, Guillem Pintos Morell, Roser Torra, Anna Vila Santandreu, Ana Güell
INTRODUCTION: Cystinosis is a rare lysosomal systemic disease that mainly affects the kidney and the eye. Patients with cystinosis begin renal replacement therapy during the first decade of life in absence of treatment. Prognosis of cystinosis depends on early diagnosis, and prompt starting and good compliance with cysteamine treatment. Kidney disease progression, extra-renal complications and shorter life expectancy are more pronounced in those patients that do not follow treatment. The objective of this work was to elaborate recommendations for the comprehensive care of cystinosis and the facilitation of patient transition from paediatric to adult treatment, based on clinical experience...
2015: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Nira Roopnarinesingh, Nancyellen Brennan, Claude Khan, Paul W Ladenson, Felicia Hill-Briggs, Rita Rastogi Kalyani
BACKGROUND: The republic of Trinidad and Tobago (T&T) is a middle income country with a comparatively high prevalence of diabetes mellitus (DM) compared to others in the Caribbean. To date, there have been no studies on health care professionals' (HCP) perspectives regarding the barriers to achieving optimal care of patients with DM in this country and few previous studies in the Caribbean, yet such perspectives are imperative to develop strategies that reduce the global burden of this disease...
2015: BMC Health Services Research
Paul Steinbok
The survival rate for childhood craniopharyngioma has been improving, with more long-term survivors. Unfortunately it is rare for the patient to be normal, either from the disease itself or from the effects of treatment. Long-term survivors of childhood craniopharyngioma suffer a number of impairments, which include visual loss, endocrinopathy, hypothalamic dysfunction, cerebrovascular problems, neurologic and neurocognitive dysfunction. Pituitary insufficiency is present in almost 100%. Visual and hypothalamic dysfunction is common...
2015: Neurologia Medico-chirurgica
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