Wilhelm Bertrams, Jochen Wilhelm, Pia-Marie Veeger, Carolina Hanko, Kristina Auf dem Brinke, Björn Klabunde, Hendrik Pott, Barbara Weckler, Timm Greulich, Claus F Vogelmeier, Bernd Schmeck
INTRODUCTION: Patients suffering from chronic obstructive pulmonary disease (COPD) are prone to acute exacerbations (AECOPD) or community acquired pneumonia (CAP), both posing severe risk of morbidity and mortality. There is no available biomarker that correctly separates AECOPD from COPD. However, because CAP and AECOPD differ in aetiology, treatment and prognosis, their discrimination would be important. METHODS: This study analysed the ability of selected candidate transcripts from peripheral blood mononuclear cells (PBMCs) to differentiate between patients with AECOPD, COPD & CAP, and CAP without pre-existing COPD...
2024: Frontiers in Medicine